-- dump date 20140620_022721 -- class Genbank::misc_feature -- table misc_feature_note -- id note 745277000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 745277000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 745277000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745277000004 Walker A motif; other site 745277000005 ATP binding site [chemical binding]; other site 745277000006 Walker B motif; other site 745277000007 arginine finger; other site 745277000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 745277000009 DnaA box-binding interface [nucleotide binding]; other site 745277000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 745277000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 745277000012 putative DNA binding surface [nucleotide binding]; other site 745277000013 dimer interface [polypeptide binding]; other site 745277000014 beta-clamp/clamp loader binding surface; other site 745277000015 beta-clamp/translesion DNA polymerase binding surface; other site 745277000016 recF protein; Region: recf; TIGR00611 745277000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745277000018 Walker A/P-loop; other site 745277000019 ATP binding site [chemical binding]; other site 745277000020 Q-loop/lid; other site 745277000021 ABC transporter signature motif; other site 745277000022 Walker B; other site 745277000023 D-loop; other site 745277000024 H-loop/switch region; other site 745277000025 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 745277000026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277000027 ATP binding site [chemical binding]; other site 745277000028 Mg2+ binding site [ion binding]; other site 745277000029 G-X-G motif; other site 745277000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 745277000031 anchoring element; other site 745277000032 dimer interface [polypeptide binding]; other site 745277000033 ATP binding site [chemical binding]; other site 745277000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 745277000035 active site 745277000036 putative metal-binding site [ion binding]; other site 745277000037 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl19286 745277000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 745277000039 sugar phosphate phosphatase; Provisional; Region: PRK10513 745277000040 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745277000041 active site 745277000042 motif I; other site 745277000043 motif II; other site 745277000044 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 745277000045 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 745277000046 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 745277000047 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 745277000048 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 745277000049 putative dimer interface [polypeptide binding]; other site 745277000050 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 745277000051 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 745277000052 putative dimer interface [polypeptide binding]; other site 745277000053 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 745277000054 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 745277000055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277000056 homodimer interface [polypeptide binding]; other site 745277000057 catalytic residue [active] 745277000058 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 745277000059 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 745277000060 dimerization interface [polypeptide binding]; other site 745277000061 ligand binding site [chemical binding]; other site 745277000062 NADP binding site [chemical binding]; other site 745277000063 catalytic site [active] 745277000064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277000065 D-galactonate transporter; Region: 2A0114; TIGR00893 745277000066 putative substrate translocation pore; other site 745277000067 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 745277000068 Transcriptional regulators [Transcription]; Region: PurR; COG1609 745277000069 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745277000070 DNA binding site [nucleotide binding] 745277000071 domain linker motif; other site 745277000072 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 745277000073 putative dimerization interface [polypeptide binding]; other site 745277000074 putative ligand binding site [chemical binding]; other site 745277000075 galactoside permease; Reviewed; Region: lacY; PRK09528 745277000076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277000077 putative substrate translocation pore; other site 745277000078 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 745277000079 Melibiase; Region: Melibiase; pfam02065 745277000080 Transcriptional regulators [Transcription]; Region: PurR; COG1609 745277000081 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745277000082 DNA binding site [nucleotide binding] 745277000083 domain linker motif; other site 745277000084 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 745277000085 ligand binding site [chemical binding]; other site 745277000086 putative outer membrane lipoprotein; Provisional; Region: PRK10510 745277000087 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 745277000088 ligand binding site [chemical binding]; other site 745277000089 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 745277000090 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 745277000091 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 745277000092 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 745277000093 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 745277000094 active site 745277000095 catalytic triad [active] 745277000096 oxyanion hole [active] 745277000097 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 745277000098 Autotransporter beta-domain; Region: Autotransporter; cl17461 745277000099 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 745277000100 dimer interface [polypeptide binding]; other site 745277000101 motif 1; other site 745277000102 active site 745277000103 motif 2; other site 745277000104 motif 3; other site 745277000105 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 745277000106 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 745277000107 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 745277000108 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 745277000109 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 745277000110 active site 745277000111 phosphorylation site [posttranslational modification] 745277000112 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 745277000113 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 745277000114 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 745277000115 active site 745277000116 P-loop; other site 745277000117 phosphorylation site [posttranslational modification] 745277000118 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 745277000119 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 745277000120 putative NAD(P) binding site [chemical binding]; other site 745277000121 catalytic Zn binding site [ion binding]; other site 745277000122 Mannitol repressor; Region: MtlR; cl11450 745277000123 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 745277000124 active site 745277000125 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 745277000126 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 745277000127 catalytic residues [active] 745277000128 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 745277000129 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 745277000130 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 745277000131 catalytic motif [active] 745277000132 Zn binding site [ion binding]; other site 745277000133 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 745277000134 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 745277000135 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 745277000136 active site 745277000137 P-loop; other site 745277000138 phosphorylation site [posttranslational modification] 745277000139 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 745277000140 active site 745277000141 phosphorylation site [posttranslational modification] 745277000142 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 745277000143 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 745277000144 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 745277000145 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 745277000146 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 745277000147 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 745277000148 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745277000149 DNA-binding site [nucleotide binding]; DNA binding site 745277000150 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 745277000151 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277000152 homodimer interface [polypeptide binding]; other site 745277000153 catalytic residue [active] 745277000154 hypothetical protein; Provisional; Region: PRK11020 745277000155 Transposase; Region: DEDD_Tnp_IS110; pfam01548 745277000156 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 745277000157 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 745277000158 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 745277000159 MOSC domain; Region: MOSC; pfam03473 745277000160 3-alpha domain; Region: 3-alpha; pfam03475 745277000161 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 745277000162 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 745277000163 dimerization interface [polypeptide binding]; other site 745277000164 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 745277000165 dimer interface [polypeptide binding]; other site 745277000166 putative CheW interface [polypeptide binding]; other site 745277000167 superoxide dismutase; Provisional; Region: PRK10925 745277000168 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 745277000169 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 745277000170 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 745277000171 Interdomain contacts; other site 745277000172 Cytokine receptor motif; other site 745277000173 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 745277000174 active site 745277000175 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 745277000176 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 745277000177 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 745277000178 [4Fe-4S] binding site [ion binding]; other site 745277000179 molybdopterin cofactor binding site; other site 745277000180 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 745277000181 molybdopterin cofactor binding site; other site 745277000182 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 745277000183 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 745277000184 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 745277000185 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 745277000186 Protein involved in formate dehydrogenase formation; Region: FdhE; cl19312 745277000187 putative glutathione S-transferase; Provisional; Region: PRK10357 745277000188 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 745277000189 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 745277000190 dimer interface [polypeptide binding]; other site 745277000191 N-terminal domain interface [polypeptide binding]; other site 745277000192 putative substrate binding pocket (H-site) [chemical binding]; other site 745277000193 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559 745277000194 NAD(P) binding site [chemical binding]; other site 745277000195 catalytic residues [active] 745277000196 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 745277000197 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 745277000198 putative acyl-acceptor binding pocket; other site 745277000199 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 745277000200 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 745277000201 putative active site [active] 745277000202 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 745277000203 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 745277000204 Walker A/P-loop; other site 745277000205 ATP binding site [chemical binding]; other site 745277000206 ABC transporter signature motif; other site 745277000207 Walker B; other site 745277000208 D-loop; other site 745277000209 H-loop/switch region; other site 745277000210 macrolide transporter subunit MacA; Provisional; Region: PRK11578 745277000211 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 745277000212 HlyD family secretion protein; Region: HlyD_3; pfam13437 745277000213 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 745277000214 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 745277000215 Walker A/P-loop; other site 745277000216 ATP binding site [chemical binding]; other site 745277000217 Q-loop/lid; other site 745277000218 ABC transporter signature motif; other site 745277000219 Walker B; other site 745277000220 D-loop; other site 745277000221 H-loop/switch region; other site 745277000222 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 745277000223 FtsX-like permease family; Region: FtsX; pfam02687 745277000224 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 745277000225 Outer membrane efflux protein; Region: OEP; pfam02321 745277000226 Outer membrane efflux protein; Region: OEP; pfam02321 745277000227 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 745277000228 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 745277000229 dimer interface [polypeptide binding]; other site 745277000230 active site 745277000231 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 745277000232 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 745277000233 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745277000234 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 745277000235 NAD(P) binding site [chemical binding]; other site 745277000236 active site 745277000237 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 745277000238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277000239 putative substrate translocation pore; other site 745277000240 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 745277000241 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 745277000242 Divergent AAA domain; Region: AAA_4; pfam04326 745277000243 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 745277000244 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 745277000245 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 745277000246 conserved cys residue [active] 745277000247 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277000248 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 745277000249 catalytic triad [active] 745277000250 conserved cis-peptide bond; other site 745277000251 DJ-1 family protein; Region: not_thiJ; TIGR01383 745277000252 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 745277000253 conserved cys residue [active] 745277000254 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 745277000255 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 745277000256 putative NAD(P) binding site [chemical binding]; other site 745277000257 catalytic Zn binding site [ion binding]; other site 745277000258 Sulfate transporter family; Region: Sulfate_transp; cl19250 745277000259 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 745277000260 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 745277000261 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745277000262 non-specific DNA binding site [nucleotide binding]; other site 745277000263 salt bridge; other site 745277000264 sequence-specific DNA binding site [nucleotide binding]; other site 745277000265 Cupin domain; Region: Cupin_2; pfam07883 745277000266 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 745277000267 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745277000268 Coenzyme A binding pocket [chemical binding]; other site 745277000269 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745277000270 Coenzyme A binding pocket [chemical binding]; other site 745277000271 Protein of unknown function (DUF796); Region: DUF796; cl01226 745277000272 glutathione S-transferase; Provisional; Region: PRK15113 745277000273 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 745277000274 C-terminal domain interface [polypeptide binding]; other site 745277000275 GSH binding site (G-site) [chemical binding]; other site 745277000276 dimer interface [polypeptide binding]; other site 745277000277 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 745277000278 N-terminal domain interface [polypeptide binding]; other site 745277000279 putative dimer interface [polypeptide binding]; other site 745277000280 putative substrate binding pocket (H-site) [chemical binding]; other site 745277000281 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745277000282 Coenzyme A binding pocket [chemical binding]; other site 745277000283 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 745277000284 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 745277000285 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 745277000286 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 745277000287 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 745277000288 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 745277000289 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 745277000290 Walker A/P-loop; other site 745277000291 ATP binding site [chemical binding]; other site 745277000292 Q-loop/lid; other site 745277000293 ABC transporter signature motif; other site 745277000294 Walker B; other site 745277000295 D-loop; other site 745277000296 H-loop/switch region; other site 745277000297 Uncharacterized ABC-type transport system, ATPase component [General function prediction only]; Region: COG4674 745277000298 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 745277000299 Walker A/P-loop; other site 745277000300 ATP binding site [chemical binding]; other site 745277000301 Q-loop/lid; other site 745277000302 ABC transporter signature motif; other site 745277000303 Walker B; other site 745277000304 D-loop; other site 745277000305 H-loop/switch region; other site 745277000306 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 745277000307 TM-ABC transporter signature motif; other site 745277000308 HEAT repeats; Region: HEAT_2; pfam13646 745277000309 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 745277000310 TM-ABC transporter signature motif; other site 745277000311 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 745277000312 putative ligand binding site [chemical binding]; other site 745277000313 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 745277000314 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745277000315 DNA-binding site [nucleotide binding]; DNA binding site 745277000316 FCD domain; Region: FCD; pfam07729 745277000317 urea carboxylase; Region: urea_carbox; TIGR02712 745277000318 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 745277000319 ATP-grasp domain; Region: ATP-grasp_4; cl17255 745277000320 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 745277000321 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 745277000322 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 745277000323 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 745277000324 carboxyltransferase (CT) interaction site; other site 745277000325 biotinylation site [posttranslational modification]; other site 745277000326 allophanate hydrolase; Provisional; Region: PRK08186 745277000327 Putative lysophospholipase; Region: Hydrolase_4; cl19140 745277000328 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 745277000329 Transcriptional regulators [Transcription]; Region: MarR; COG1846 745277000330 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 745277000331 putative DNA binding site [nucleotide binding]; other site 745277000332 putative Zn2+ binding site [ion binding]; other site 745277000333 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 745277000334 phosphoethanolamine transferase; Provisional; Region: PRK11560 745277000335 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 745277000336 Sulfatase; Region: Sulfatase; pfam00884 745277000337 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 745277000338 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 745277000339 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 745277000340 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 745277000341 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 745277000342 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277000343 Walker A/P-loop; other site 745277000344 ATP binding site [chemical binding]; other site 745277000345 Q-loop/lid; other site 745277000346 ABC transporter signature motif; other site 745277000347 Walker B; other site 745277000348 D-loop; other site 745277000349 H-loop/switch region; other site 745277000350 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 745277000351 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277000352 Walker A/P-loop; other site 745277000353 ATP binding site [chemical binding]; other site 745277000354 Q-loop/lid; other site 745277000355 ABC transporter signature motif; other site 745277000356 Walker B; other site 745277000357 D-loop; other site 745277000358 H-loop/switch region; other site 745277000359 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745277000360 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 745277000361 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 745277000362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277000363 dimer interface [polypeptide binding]; other site 745277000364 conserved gate region; other site 745277000365 putative PBP binding loops; other site 745277000366 ABC-ATPase subunit interface; other site 745277000367 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 745277000368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277000369 dimer interface [polypeptide binding]; other site 745277000370 conserved gate region; other site 745277000371 putative PBP binding loops; other site 745277000372 ABC-ATPase subunit interface; other site 745277000373 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 745277000374 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 745277000375 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 745277000376 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 745277000377 putative metal binding site [ion binding]; other site 745277000378 cell density-dependent motility repressor; Provisional; Region: PRK10082 745277000379 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277000380 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 745277000381 dimerization interface [polypeptide binding]; other site 745277000382 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 745277000383 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 745277000384 peptide binding site [polypeptide binding]; other site 745277000385 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 745277000386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277000387 dimer interface [polypeptide binding]; other site 745277000388 conserved gate region; other site 745277000389 putative PBP binding loops; other site 745277000390 ABC-ATPase subunit interface; other site 745277000391 dipeptide transporter; Provisional; Region: PRK10913 745277000392 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 745277000393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277000394 dimer interface [polypeptide binding]; other site 745277000395 conserved gate region; other site 745277000396 putative PBP binding loops; other site 745277000397 ABC-ATPase subunit interface; other site 745277000398 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 745277000399 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277000400 Walker A/P-loop; other site 745277000401 ATP binding site [chemical binding]; other site 745277000402 Q-loop/lid; other site 745277000403 ABC transporter signature motif; other site 745277000404 Walker B; other site 745277000405 D-loop; other site 745277000406 H-loop/switch region; other site 745277000407 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745277000408 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 745277000409 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277000410 Walker A/P-loop; other site 745277000411 ATP binding site [chemical binding]; other site 745277000412 Q-loop/lid; other site 745277000413 ABC transporter signature motif; other site 745277000414 Walker B; other site 745277000415 D-loop; other site 745277000416 H-loop/switch region; other site 745277000417 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745277000418 mobile mystery protein B; Region: mob_myst_B; TIGR02613 745277000419 Fic/DOC family; Region: Fic; cl00960 745277000420 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 745277000421 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745277000422 non-specific DNA binding site [nucleotide binding]; other site 745277000423 salt bridge; other site 745277000424 sequence-specific DNA binding site [nucleotide binding]; other site 745277000425 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 745277000426 Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500 745277000427 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 745277000428 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 745277000429 binding surface 745277000430 TPR motif; other site 745277000431 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 745277000432 cellulose synthase regulator protein; Provisional; Region: PRK11114 745277000433 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 745277000434 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 745277000435 DXD motif; other site 745277000436 PilZ domain; Region: PilZ; pfam07238 745277000437 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 745277000438 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 745277000439 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 745277000440 P-loop; other site 745277000441 Magnesium ion binding site [ion binding]; other site 745277000442 Topoisomerase II-associated protein PAT1; Region: PAT1; pfam09770 745277000443 putative diguanylate cyclase; Provisional; Region: PRK13561 745277000444 HAMP domain; Region: HAMP; pfam00672 745277000445 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 745277000446 nucleotidyl binding site; other site 745277000447 metal binding site [ion binding]; metal-binding site 745277000448 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 745277000449 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 745277000450 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 745277000451 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 745277000452 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 745277000453 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 745277000454 substrate binding site [chemical binding]; other site 745277000455 ATP binding site [chemical binding]; other site 745277000456 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 745277000457 active site 1 [active] 745277000458 dimer interface [polypeptide binding]; other site 745277000459 hexamer interface [polypeptide binding]; other site 745277000460 active site 2 [active] 745277000461 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 745277000462 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 745277000463 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 745277000464 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 745277000465 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 745277000466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277000467 metabolite-proton symporter; Region: 2A0106; TIGR00883 745277000468 putative substrate translocation pore; other site 745277000469 inner membrane protein YhjD; Region: TIGR00766 745277000470 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277000471 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277000472 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 745277000473 putative effector binding pocket; other site 745277000474 putative dimerization interface [polypeptide binding]; other site 745277000475 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 745277000476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745277000477 NAD(P) binding site [chemical binding]; other site 745277000478 active site 745277000479 Flagellar regulator YcgR; Region: YcgR; pfam07317 745277000480 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 745277000481 PilZ domain; Region: PilZ; pfam07238 745277000482 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 745277000483 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 745277000484 binding surface 745277000485 TPR repeat; Region: TPR_11; pfam13414 745277000486 TPR motif; other site 745277000487 Tetratricopeptide repeat; Region: TPR_19; pfam14559 745277000488 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 745277000489 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 745277000490 DNA binding residues [nucleotide binding] 745277000491 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 745277000492 malate:quinone oxidoreductase; Validated; Region: PRK05257 745277000493 Predicted dehydrogenase [General function prediction only]; Region: COG0579 745277000494 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 745277000495 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 745277000496 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 745277000497 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 745277000498 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 745277000499 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 745277000500 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 745277000501 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 745277000502 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 745277000503 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 745277000504 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 745277000505 Uncharacterized alpha/beta hydrolase domain (DUF2235); Region: DUF2235; cl01480 745277000506 malate:quinone oxidoreductase; Validated; Region: PRK05257 745277000507 Predicted dehydrogenase [General function prediction only]; Region: COG0579 745277000508 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 745277000509 Na binding site [ion binding]; other site 745277000510 Virulence protein [General function prediction only]; Region: COG3943 745277000511 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 745277000512 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 745277000513 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 745277000514 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 745277000515 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 745277000516 active site 745277000517 Zn binding site [ion binding]; other site 745277000518 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 745277000519 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 745277000520 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277000521 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 745277000522 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 745277000523 DNA binding site [nucleotide binding] 745277000524 active site 745277000525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277000526 Major Facilitator Superfamily; Region: MFS_1; pfam07690 745277000527 putative substrate translocation pore; other site 745277000528 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 745277000529 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745277000530 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 745277000531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277000532 putative substrate translocation pore; other site 745277000533 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 745277000534 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 745277000535 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745277000536 Walker A/P-loop; other site 745277000537 ATP binding site [chemical binding]; other site 745277000538 Q-loop/lid; other site 745277000539 ABC transporter signature motif; other site 745277000540 Walker B; other site 745277000541 D-loop; other site 745277000542 H-loop/switch region; other site 745277000543 Protein of unknown function, DUF482; Region: DUF482; pfam04339 745277000544 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 745277000545 active site clefts [active] 745277000546 zinc binding site [ion binding]; other site 745277000547 dimer interface [polypeptide binding]; other site 745277000548 methionine sulfoxide reductase A; Provisional; Region: PRK14054 745277000549 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 745277000550 active site 1 [active] 745277000551 dimer interface [polypeptide binding]; other site 745277000552 hexamer interface [polypeptide binding]; other site 745277000553 active site 2 [active] 745277000554 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 745277000555 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 745277000556 active site 745277000557 P-loop; other site 745277000558 phosphorylation site [posttranslational modification] 745277000559 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 745277000560 active site 745277000561 phosphorylation site [posttranslational modification] 745277000562 AAA domain; Region: AAA_17; pfam13207 745277000563 Class I aldolases; Region: Aldolase_Class_I; cl17187 745277000564 catalytic residue [active] 745277000565 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 745277000566 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 745277000567 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 745277000568 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 745277000569 Putative lysophospholipase; Region: Hydrolase_4; cl19140 745277000570 Putative lysophospholipase; Region: Hydrolase_4; cl19140 745277000571 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 745277000572 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 745277000573 catalytic triad [active] 745277000574 dimer interface [polypeptide binding]; other site 745277000575 conserved cis-peptide bond; other site 745277000576 Predicted membrane protein [Function unknown]; Region: COG2259 745277000577 Transmembrane secretion effector; Region: MFS_3; pfam05977 745277000578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277000579 putative substrate translocation pore; other site 745277000580 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 745277000581 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277000582 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 745277000583 dimerization interface [polypeptide binding]; other site 745277000584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 745277000585 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 745277000586 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 745277000587 GIY-YIG motif/motif A; other site 745277000588 active site 745277000589 catalytic site [active] 745277000590 putative DNA binding site [nucleotide binding]; other site 745277000591 metal binding site [ion binding]; metal-binding site 745277000592 glutathione reductase; Validated; Region: PRK06116 745277000593 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 745277000594 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 745277000595 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 745277000596 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 745277000597 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 745277000598 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 745277000599 active site 745277000600 Zn binding site [ion binding]; other site 745277000601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277000602 S-adenosylmethionine binding site [chemical binding]; other site 745277000603 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 745277000604 Ligand Binding Site [chemical binding]; other site 745277000605 universal stress protein UspB; Provisional; Region: PRK04960 745277000606 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 745277000607 Predicted flavoproteins [General function prediction only]; Region: COG2081 745277000608 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 745277000609 Beta-lactamase; Region: Beta-lactamase; pfam00144 745277000610 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 745277000611 putative acyl-acceptor binding pocket; other site 745277000612 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 745277000613 major facilitator superfamily transporter; Provisional; Region: PRK05122 745277000614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277000615 putative substrate translocation pore; other site 745277000616 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 745277000617 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745277000618 Coenzyme A binding pocket [chemical binding]; other site 745277000619 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 745277000620 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 745277000621 Pirin-related protein [General function prediction only]; Region: COG1741 745277000622 Pirin; Region: Pirin; pfam02678 745277000623 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 745277000624 Autotransporter beta-domain; Region: Autotransporter; smart00869 745277000625 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 745277000626 active site 745277000627 P-loop; other site 745277000628 phosphorylation site [posttranslational modification] 745277000629 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 745277000630 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 745277000631 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 745277000632 Transcriptional regulators [Transcription]; Region: PurR; COG1609 745277000633 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745277000634 DNA binding site [nucleotide binding] 745277000635 domain linker motif; other site 745277000636 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 745277000637 ligand binding site [chemical binding]; other site 745277000638 dimerization interface [polypeptide binding]; other site 745277000639 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 745277000640 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745277000641 DNA binding site [nucleotide binding] 745277000642 domain linker motif; other site 745277000643 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 745277000644 putative ligand binding site [chemical binding]; other site 745277000645 putative dimerization interface [polypeptide binding]; other site 745277000646 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 745277000647 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 745277000648 putative transposase OrfB; Reviewed; Region: PHA02517 745277000649 HTH-like domain; Region: HTH_21; pfam13276 745277000650 Integrase core domain; Region: rve; pfam00665 745277000651 Integrase core domain; Region: rve_2; pfam13333 745277000652 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 745277000653 AAA domain; Region: AAA_33; pfam13671 745277000654 ATP-binding site [chemical binding]; other site 745277000655 Gluconate-6-phosphate binding site [chemical binding]; other site 745277000656 high-affinity gluconate transporter; Provisional; Region: PRK14984 745277000657 GntP family permease; Region: GntP_permease; pfam02447 745277000658 putative antibiotic transporter; Provisional; Region: PRK10739 745277000659 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 745277000660 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 745277000661 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 745277000662 glycogen branching enzyme; Provisional; Region: PRK05402 745277000663 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 745277000664 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 745277000665 active site 745277000666 catalytic site [active] 745277000667 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 745277000668 glycogen debranching enzyme; Provisional; Region: PRK03705 745277000669 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 745277000670 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 745277000671 active site 745277000672 catalytic site [active] 745277000673 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 745277000674 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 745277000675 ligand binding site; other site 745277000676 oligomer interface; other site 745277000677 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 745277000678 sulfate 1 binding site; other site 745277000679 glycogen synthase; Provisional; Region: glgA; PRK00654 745277000680 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 745277000681 ADP-binding pocket [chemical binding]; other site 745277000682 homodimer interface [polypeptide binding]; other site 745277000683 glycogen phosphorylase; Provisional; Region: PRK14986 745277000684 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 745277000685 homodimer interface [polypeptide binding]; other site 745277000686 active site pocket [active] 745277000687 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 745277000688 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 745277000689 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 745277000690 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 745277000691 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 745277000692 intramembrane serine protease GlpG; Provisional; Region: PRK10907 745277000693 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 745277000694 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 745277000695 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 745277000696 homodimer interface [polypeptide binding]; other site 745277000697 substrate-cofactor binding pocket; other site 745277000698 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277000699 catalytic residue [active] 745277000700 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 745277000701 active site residue [active] 745277000702 transcriptional repressor UlaR; Provisional; Region: PRK13509 745277000703 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 745277000704 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 745277000705 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 745277000706 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 745277000707 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 745277000708 active site 745277000709 P-loop; other site 745277000710 phosphorylation site [posttranslational modification] 745277000711 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 745277000712 active site 745277000713 phosphorylation site [posttranslational modification] 745277000714 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 745277000715 active site 745277000716 dimer interface [polypeptide binding]; other site 745277000717 magnesium binding site [ion binding]; other site 745277000718 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 745277000719 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 745277000720 AP (apurinic/apyrimidinic) site pocket; other site 745277000721 DNA interaction; other site 745277000722 Metal-binding active site; metal-binding site 745277000723 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 745277000724 intersubunit interface [polypeptide binding]; other site 745277000725 active site 745277000726 Zn2+ binding site [ion binding]; other site 745277000727 maltodextrin phosphorylase; Provisional; Region: PRK14985 745277000728 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 745277000729 active site pocket [active] 745277000730 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 745277000731 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 745277000732 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 745277000733 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 745277000734 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 745277000735 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 745277000736 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 745277000737 active site 745277000738 carboxylesterase BioH; Provisional; Region: PRK10349 745277000739 Putative lysophospholipase; Region: Hydrolase_4; cl19140 745277000740 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 745277000741 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 745277000742 Coenzyme A transferase; Region: CoA_trans; cl17247 745277000743 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 745277000744 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 745277000745 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 745277000746 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 745277000747 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 745277000748 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 745277000749 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 745277000750 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 745277000751 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 745277000752 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277000753 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277000754 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 745277000755 dimerization interface [polypeptide binding]; other site 745277000756 FeoC like transcriptional regulator; Region: FeoC; cl17677 745277000757 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 745277000758 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 745277000759 G1 box; other site 745277000760 GTP/Mg2+ binding site [chemical binding]; other site 745277000761 Switch I region; other site 745277000762 G2 box; other site 745277000763 G3 box; other site 745277000764 Switch II region; other site 745277000765 G4 box; other site 745277000766 G5 box; other site 745277000767 Nucleoside recognition; Region: Gate; pfam07670 745277000768 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 745277000769 Nucleoside recognition; Region: Gate; pfam07670 745277000770 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 745277000771 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 745277000772 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 745277000773 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 745277000774 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 745277000775 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 745277000776 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 745277000777 RNA binding site [nucleotide binding]; other site 745277000778 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 745277000779 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 745277000780 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 745277000781 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 745277000782 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 745277000783 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 745277000784 MG2 domain; Region: A2M_N; pfam01835 745277000785 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 745277000786 Alpha-2-macroglobulin family; Region: A2M; pfam00207 745277000787 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 745277000788 surface patch; other site 745277000789 thioester region; other site 745277000790 specificity defining residues; other site 745277000791 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 745277000792 Transglycosylase; Region: Transgly; pfam00912 745277000793 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 745277000794 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 745277000795 Fimbrial protein; Region: Fimbrial; cl01416 745277000796 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 745277000797 PapC N-terminal domain; Region: PapC_N; pfam13954 745277000798 Outer membrane usher protein; Region: Usher; pfam00577 745277000799 PapC C-terminal domain; Region: PapC_C; pfam13953 745277000800 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 745277000801 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 745277000802 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 745277000803 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 745277000804 osmolarity response regulator; Provisional; Region: ompR; PRK09468 745277000805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277000806 active site 745277000807 phosphorylation site [posttranslational modification] 745277000808 intermolecular recognition site; other site 745277000809 dimerization interface [polypeptide binding]; other site 745277000810 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 745277000811 DNA binding site [nucleotide binding] 745277000812 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 745277000813 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 745277000814 dimerization interface [polypeptide binding]; other site 745277000815 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745277000816 dimer interface [polypeptide binding]; other site 745277000817 phosphorylation site [posttranslational modification] 745277000818 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277000819 ATP binding site [chemical binding]; other site 745277000820 Mg2+ binding site [ion binding]; other site 745277000821 G-X-G motif; other site 745277000822 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 745277000823 active site 745277000824 substrate-binding site [chemical binding]; other site 745277000825 metal-binding site [ion binding] 745277000826 ATP binding site [chemical binding]; other site 745277000827 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 745277000828 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 745277000829 dimerization interface [polypeptide binding]; other site 745277000830 domain crossover interface; other site 745277000831 redox-dependent activation switch; other site 745277000832 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 745277000833 RNA binding surface [nucleotide binding]; other site 745277000834 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 745277000835 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745277000836 motif II; other site 745277000837 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 745277000838 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 745277000839 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 745277000840 ADP-ribose binding site [chemical binding]; other site 745277000841 dimer interface [polypeptide binding]; other site 745277000842 active site 745277000843 nudix motif; other site 745277000844 metal binding site [ion binding]; metal-binding site 745277000845 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 745277000846 Transglycosylase; Region: Transgly; pfam00912 745277000847 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 745277000848 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 745277000849 Fimbrial assembly protein (PilN); Region: PilN; cl19830 745277000850 Pilus assembly protein, PilO; Region: PilO; cl01234 745277000851 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 745277000852 putative outer membrane porin HofQ; Provisional; Region: hofQ; PRK13568 745277000853 Secretin and TonB N terminus short domain; Region: STN; pfam07660 745277000854 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 745277000855 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 745277000856 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 745277000857 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 745277000858 ADP binding site [chemical binding]; other site 745277000859 magnesium binding site [ion binding]; other site 745277000860 putative shikimate binding site; other site 745277000861 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 745277000862 active site 745277000863 dimer interface [polypeptide binding]; other site 745277000864 metal binding site [ion binding]; metal-binding site 745277000865 hypothetical protein; Reviewed; Region: PRK11901 745277000866 Sporulation related domain; Region: SPOR; pfam05036 745277000867 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 745277000868 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 745277000869 substrate binding site [chemical binding]; other site 745277000870 hexamer interface [polypeptide binding]; other site 745277000871 metal binding site [ion binding]; metal-binding site 745277000872 phosphoglycolate phosphatase; Provisional; Region: PRK13222 745277000873 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745277000874 motif II; other site 745277000875 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 745277000876 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 745277000877 active site 745277000878 HIGH motif; other site 745277000879 dimer interface [polypeptide binding]; other site 745277000880 KMSKS motif; other site 745277000881 siroheme synthase; Provisional; Region: cysG; PRK10637 745277000882 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 745277000883 Sirohaem biosynthesis protein central; Region: Sirohm_synth_M; pfam14824 745277000884 Sirohaem synthase dimerization region; Region: CysG_dimeriser; pfam10414 745277000885 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 745277000886 active site 745277000887 SAM binding site [chemical binding]; other site 745277000888 homodimer interface [polypeptide binding]; other site 745277000889 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 745277000890 nitrite reductase subunit NirD; Provisional; Region: PRK14989 745277000891 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 745277000892 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 745277000893 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 745277000894 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 745277000895 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 745277000896 active site 745277000897 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 745277000898 substrate binding site [chemical binding]; other site 745277000899 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 745277000900 active site 745277000901 catalytic residues [active] 745277000902 Protein of unknown function (DUF2559); Region: DUF2559; cl08097 745277000903 Fic/DOC family; Region: Fic; cl00960 745277000904 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 745277000905 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 745277000906 glutamine binding [chemical binding]; other site 745277000907 catalytic triad [active] 745277000908 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 745277000909 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 745277000910 inhibitor-cofactor binding pocket; inhibition site 745277000911 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277000912 catalytic residue [active] 745277000913 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 745277000914 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 745277000915 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 745277000916 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 745277000917 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 745277000918 ligand binding site [chemical binding]; other site 745277000919 flexible hinge region; other site 745277000920 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 745277000921 putative switch regulator; other site 745277000922 non-specific DNA interactions [nucleotide binding]; other site 745277000923 DNA binding site [nucleotide binding] 745277000924 sequence specific DNA binding site [nucleotide binding]; other site 745277000925 putative cAMP binding site [chemical binding]; other site 745277000926 hypothetical protein; Provisional; Region: PRK10738 745277000927 phosphoribulokinase; Provisional; Region: PRK15453 745277000928 active site 745277000929 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 745277000930 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277000931 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 745277000932 dimerization interface [polypeptide binding]; other site 745277000933 ureidoglycolate hydrolase; Provisional; Region: PRK03606 745277000934 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 745277000935 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 745277000936 Bacterial transcriptional regulator; Region: IclR; pfam01614 745277000937 glyoxylate carboligase; Provisional; Region: PRK11269 745277000938 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 745277000939 PYR/PP interface [polypeptide binding]; other site 745277000940 dimer interface [polypeptide binding]; other site 745277000941 TPP binding site [chemical binding]; other site 745277000942 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 745277000943 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 745277000944 TPP-binding site [chemical binding]; other site 745277000945 hydroxypyruvate isomerase; Provisional; Region: PRK09997 745277000946 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 745277000947 tartronate semialdehyde reductase; Provisional; Region: PRK15059 745277000948 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 745277000949 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 745277000950 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 745277000951 Na binding site [ion binding]; other site 745277000952 putative substrate binding site [chemical binding]; other site 745277000953 allantoinase; Provisional; Region: PRK08044 745277000954 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 745277000955 active site 745277000956 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 745277000957 Sulfate transporter family; Region: Sulfate_transp; cl19250 745277000958 putative allantoin catabolism protein; Region: ura-cupin; TIGR03214 745277000959 Cupin domain; Region: Cupin_2; cl17218 745277000960 Cupin domain; Region: Cupin_2; cl17218 745277000961 allantoate amidohydrolase; Region: AllC; TIGR03176 745277000962 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 745277000963 active site 745277000964 metal binding site [ion binding]; metal-binding site 745277000965 dimer interface [polypeptide binding]; other site 745277000966 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 745277000967 membrane protein FdrA; Validated; Region: PRK06091 745277000968 CoA binding domain; Region: CoA_binding; pfam02629 745277000969 CoA-ligase; Region: Ligase_CoA; pfam00549 745277000970 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 745277000971 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 745277000972 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 745277000973 putative substrate binding site [chemical binding]; other site 745277000974 nucleotide binding site [chemical binding]; other site 745277000975 nucleotide binding site [chemical binding]; other site 745277000976 homodimer interface [polypeptide binding]; other site 745277000977 hypothetical protein; Provisional; Region: PRK04966 745277000978 putative hydrolase; Provisional; Region: PRK10985 745277000979 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 745277000980 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 745277000981 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 745277000982 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 745277000983 ABC transporter; Region: ABC_tran_2; pfam12848 745277000984 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 745277000985 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 745277000986 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 745277000987 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 745277000988 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 745277000989 TrkA-N domain; Region: TrkA_N; pfam02254 745277000990 Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526 745277000991 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 745277000992 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 745277000993 phi X174 lysis protein; Provisional; Region: PRK02793 745277000994 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 745277000995 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 745277000996 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 745277000997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 745277000998 YheO-like PAS domain; Region: PAS_6; pfam08348 745277000999 HTH domain; Region: HTH_22; pfam13309 745277001000 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 745277001001 sulfur relay protein TusC; Validated; Region: PRK00211 745277001002 DsrH like protein; Region: DsrH; cl17347 745277001003 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 745277001004 S17 interaction site [polypeptide binding]; other site 745277001005 S8 interaction site; other site 745277001006 16S rRNA interaction site [nucleotide binding]; other site 745277001007 streptomycin interaction site [chemical binding]; other site 745277001008 23S rRNA interaction site [nucleotide binding]; other site 745277001009 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 745277001010 30S ribosomal protein S7; Validated; Region: PRK05302 745277001011 elongation factor G; Reviewed; Region: PRK00007 745277001012 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 745277001013 G1 box; other site 745277001014 putative GEF interaction site [polypeptide binding]; other site 745277001015 GTP/Mg2+ binding site [chemical binding]; other site 745277001016 Switch I region; other site 745277001017 G2 box; other site 745277001018 G3 box; other site 745277001019 Switch II region; other site 745277001020 G4 box; other site 745277001021 G5 box; other site 745277001022 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 745277001023 Elongation Factor G, domain II; Region: EFG_II; pfam14492 745277001024 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 745277001025 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 745277001026 elongation factor Tu; Reviewed; Region: PRK00049 745277001027 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 745277001028 G1 box; other site 745277001029 GEF interaction site [polypeptide binding]; other site 745277001030 GTP/Mg2+ binding site [chemical binding]; other site 745277001031 Switch I region; other site 745277001032 G2 box; other site 745277001033 G3 box; other site 745277001034 Switch II region; other site 745277001035 G4 box; other site 745277001036 G5 box; other site 745277001037 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 745277001038 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 745277001039 Antibiotic Binding Site [chemical binding]; other site 745277001040 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 745277001041 aromatic chitin/cellulose binding site residues [chemical binding]; other site 745277001042 Glyco_18 domain; Region: Glyco_18; smart00636 745277001043 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 745277001044 active site 745277001045 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 745277001046 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 745277001047 Ferritin-like domain; Region: Ferritin; pfam00210 745277001048 heme binding site [chemical binding]; other site 745277001049 ferroxidase pore; other site 745277001050 ferroxidase diiron center [ion binding]; other site 745277001051 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 745277001052 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 745277001053 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 745277001054 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 745277001055 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 745277001056 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 745277001057 GspL periplasmic domain; Region: GspL_C; pfam12693 745277001058 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 745277001059 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 745277001060 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 745277001061 type II secretion system protein J; Region: gspJ; TIGR01711 745277001062 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 745277001063 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 745277001064 type II secretion system protein I; Region: gspI; TIGR01707 745277001065 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 745277001066 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 745277001067 Type II transport protein GspH; Region: GspH; pfam12019 745277001068 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 745277001069 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 745277001070 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 745277001071 type II secretion system protein F; Region: GspF; TIGR02120 745277001072 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 745277001073 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 745277001074 type II secretion system protein E; Region: type_II_gspE; TIGR02533 745277001075 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 745277001076 Walker A motif; other site 745277001077 ATP binding site [chemical binding]; other site 745277001078 Walker B motif; other site 745277001079 type II secretion system protein D; Region: type_II_gspD; TIGR02517 745277001080 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 745277001081 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 745277001082 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 745277001083 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 745277001084 Type II secretory pathway, component PulC [Intracellular trafficking and secretion]; Region: PulC; COG3031 745277001085 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 745277001086 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 745277001087 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 745277001088 AAA domain; Region: AAA_22; pfam13401 745277001089 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 745277001090 protein secretion protein GspB; Provisional; Region: PRK09697 745277001091 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 745277001092 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 745277001093 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 745277001094 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 745277001095 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 745277001096 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 745277001097 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 745277001098 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 745277001099 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 745277001100 protein-rRNA interface [nucleotide binding]; other site 745277001101 putative translocon binding site; other site 745277001102 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 745277001103 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 745277001104 G-X-X-G motif; other site 745277001105 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 745277001106 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 745277001107 23S rRNA interface [nucleotide binding]; other site 745277001108 5S rRNA interface [nucleotide binding]; other site 745277001109 putative antibiotic binding site [chemical binding]; other site 745277001110 L25 interface [polypeptide binding]; other site 745277001111 L27 interface [polypeptide binding]; other site 745277001112 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 745277001113 23S rRNA interface [nucleotide binding]; other site 745277001114 putative translocon interaction site; other site 745277001115 signal recognition particle (SRP54) interaction site; other site 745277001116 L23 interface [polypeptide binding]; other site 745277001117 trigger factor interaction site; other site 745277001118 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 745277001119 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 745277001120 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 745277001121 RNA binding site [nucleotide binding]; other site 745277001122 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 745277001123 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 745277001124 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 745277001125 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 745277001126 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 745277001127 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 745277001128 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 745277001129 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 745277001130 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 745277001131 23S rRNA interface [nucleotide binding]; other site 745277001132 5S rRNA interface [nucleotide binding]; other site 745277001133 L27 interface [polypeptide binding]; other site 745277001134 L5 interface [polypeptide binding]; other site 745277001135 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 745277001136 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 745277001137 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 745277001138 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 745277001139 23S rRNA binding site [nucleotide binding]; other site 745277001140 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 745277001141 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 745277001142 SecY translocase; Region: SecY; pfam00344 745277001143 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 745277001144 Alpha operon ribosome binding site; IMG reference gene:2506707407 745277001145 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 745277001146 30S ribosomal protein S11; Validated; Region: PRK05309 745277001147 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 745277001148 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 745277001149 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 745277001150 RNA binding surface [nucleotide binding]; other site 745277001151 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 745277001152 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 745277001153 alphaNTD homodimer interface [polypeptide binding]; other site 745277001154 alphaNTD - beta interaction site [polypeptide binding]; other site 745277001155 alphaNTD - beta' interaction site [polypeptide binding]; other site 745277001156 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 745277001157 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 745277001158 hypothetical protein; Provisional; Region: PRK10203 745277001159 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 745277001160 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 745277001161 DNA binding residues [nucleotide binding] 745277001162 dimer interface [polypeptide binding]; other site 745277001163 metal binding site [ion binding]; metal-binding site 745277001164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 745277001165 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 745277001166 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 745277001167 TrkA-N domain; Region: TrkA_N; pfam02254 745277001168 TrkA-C domain; Region: TrkA_C; pfam02080 745277001169 TrkA-N domain; Region: TrkA_N; pfam02254 745277001170 TrkA-C domain; Region: TrkA_C; pfam02080 745277001171 16S rRNA methyltransferase B; Provisional; Region: PRK10901 745277001172 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 745277001173 putative RNA binding site [nucleotide binding]; other site 745277001174 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277001175 S-adenosylmethionine binding site [chemical binding]; other site 745277001176 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 745277001177 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 745277001178 putative active site [active] 745277001179 substrate binding site [chemical binding]; other site 745277001180 putative cosubstrate binding site; other site 745277001181 catalytic site [active] 745277001182 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 745277001183 substrate binding site [chemical binding]; other site 745277001184 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 745277001185 active site 745277001186 catalytic residues [active] 745277001187 metal binding site [ion binding]; metal-binding site 745277001188 hypothetical protein; Provisional; Region: PRK10736 745277001189 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 745277001190 hypothetical protein; Validated; Region: PRK03430 745277001191 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 745277001192 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 745277001193 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 745277001194 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 745277001195 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 745277001196 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 745277001197 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 745277001198 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 745277001199 shikimate binding site; other site 745277001200 NAD(P) binding site [chemical binding]; other site 745277001201 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 745277001202 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 745277001203 trimer interface [polypeptide binding]; other site 745277001204 putative metal binding site [ion binding]; other site 745277001205 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 745277001206 Na binding site [ion binding]; other site 745277001207 Predicted membrane protein [Function unknown]; Region: COG3162 745277001208 acetyl-CoA synthetase; Provisional; Region: PRK00174 745277001209 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 745277001210 active site 745277001211 CoA binding site [chemical binding]; other site 745277001212 acyl-activating enzyme (AAE) consensus motif; other site 745277001213 AMP binding site [chemical binding]; other site 745277001214 acetate binding site [chemical binding]; other site 745277001215 Fimbrial protein; Region: Fimbrial; cl01416 745277001216 fimbrial outer membrane usher protein StdB; Provisional; Region: PRK15255 745277001217 PapC N-terminal domain; Region: PapC_N; pfam13954 745277001218 Outer membrane usher protein; Region: Usher; pfam00577 745277001219 PapC C-terminal domain; Region: PapC_C; pfam13953 745277001220 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 745277001221 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 745277001222 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 745277001223 Fimbrial protein; Region: Fimbrial; pfam00419 745277001224 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745277001225 non-specific DNA binding site [nucleotide binding]; other site 745277001226 salt bridge; other site 745277001227 sequence-specific DNA binding site [nucleotide binding]; other site 745277001228 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 745277001229 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 745277001230 DNA binding site [nucleotide binding] 745277001231 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 745277001232 putative dimer interface [polypeptide binding]; other site 745277001233 catalytic triad [active] 745277001234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277001235 D-galactonate transporter; Region: 2A0114; TIGR00893 745277001236 putative substrate translocation pore; other site 745277001237 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 745277001238 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 745277001239 active site pocket [active] 745277001240 putative transcriptional regulator; Provisional; Region: PRK11640 745277001241 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 745277001242 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 745277001243 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 745277001244 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 745277001245 DsbD alpha interface [polypeptide binding]; other site 745277001246 catalytic residues [active] 745277001247 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 745277001248 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 745277001249 Aspartase; Region: Aspartase; cd01357 745277001250 active sites [active] 745277001251 tetramer interface [polypeptide binding]; other site 745277001252 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 745277001253 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 745277001254 oligomerisation interface [polypeptide binding]; other site 745277001255 mobile loop; other site 745277001256 roof hairpin; other site 745277001257 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 745277001258 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 745277001259 ring oligomerisation interface [polypeptide binding]; other site 745277001260 ATP/Mg binding site [chemical binding]; other site 745277001261 stacking interactions; other site 745277001262 hinge regions; other site 745277001263 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 745277001264 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 745277001265 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 745277001266 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 745277001267 FeS/SAM binding site; other site 745277001268 elongation factor P; Validated; Region: PRK00529 745277001269 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 745277001270 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 745277001271 RNA binding site [nucleotide binding]; other site 745277001272 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 745277001273 RNA binding site [nucleotide binding]; other site 745277001274 Entericidin EcnA/B family; Region: Entericidin; cl02322 745277001275 Entericidin EcnA/B family; Region: Entericidin; cl02322 745277001276 Lipocalin-like domain; Region: Lipocalin_2; cl19222 745277001277 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 745277001278 Iron-sulfur protein interface; other site 745277001279 proximal quinone binding site [chemical binding]; other site 745277001280 C-subunit interface; other site 745277001281 distal quinone binding site; other site 745277001282 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 745277001283 D-subunit interface [polypeptide binding]; other site 745277001284 Iron-sulfur protein interface; other site 745277001285 proximal quinone binding site [chemical binding]; other site 745277001286 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 745277001287 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 745277001288 catalytic loop [active] 745277001289 iron binding site [ion binding]; other site 745277001290 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 745277001291 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 745277001292 L-aspartate oxidase; Provisional; Region: PRK06175 745277001293 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 745277001294 poxB regulator PoxA; Provisional; Region: PRK09350 745277001295 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 745277001296 motif 1; other site 745277001297 dimer interface [polypeptide binding]; other site 745277001298 active site 745277001299 motif 2; other site 745277001300 motif 3; other site 745277001301 putative mechanosensitive channel protein; Provisional; Region: PRK10929 745277001302 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 745277001303 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 745277001304 Mechanosensitive ion channel; Region: MS_channel; pfam00924 745277001305 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 745277001306 GTPase RsgA; Reviewed; Region: PRK12288 745277001307 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 745277001308 RNA binding site [nucleotide binding]; other site 745277001309 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 745277001310 GTPase/Zn-binding domain interface [polypeptide binding]; other site 745277001311 GTP/Mg2+ binding site [chemical binding]; other site 745277001312 G4 box; other site 745277001313 G5 box; other site 745277001314 G1 box; other site 745277001315 Switch I region; other site 745277001316 G2 box; other site 745277001317 G3 box; other site 745277001318 Switch II region; other site 745277001319 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 745277001320 catalytic site [active] 745277001321 putative active site [active] 745277001322 putative substrate binding site [chemical binding]; other site 745277001323 dimer interface [polypeptide binding]; other site 745277001324 epoxyqueuosine reductase; Region: TIGR00276 745277001325 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 745277001326 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 745277001327 putative carbohydrate kinase; Provisional; Region: PRK10565 745277001328 Uncharacterized conserved protein [Function unknown]; Region: COG0062 745277001329 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 745277001330 putative substrate binding site [chemical binding]; other site 745277001331 putative ATP binding site [chemical binding]; other site 745277001332 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 745277001333 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 745277001334 AMIN domain; Region: AMIN; pfam11741 745277001335 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 745277001336 active site 745277001337 metal binding site [ion binding]; metal-binding site 745277001338 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 745277001339 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 745277001340 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 745277001341 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 745277001342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277001343 ATP binding site [chemical binding]; other site 745277001344 Mg2+ binding site [ion binding]; other site 745277001345 G-X-G motif; other site 745277001346 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 745277001347 ATP binding site [chemical binding]; other site 745277001348 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 745277001349 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745277001350 AAA domain; Region: AAA_33; pfam13671 745277001351 Walker A motif; other site 745277001352 ATP binding site [chemical binding]; other site 745277001353 IPP transferase; Region: IPPT; pfam01715 745277001354 bacterial Hfq-like; Region: Hfq; cd01716 745277001355 hexamer interface [polypeptide binding]; other site 745277001356 Sm1 motif; other site 745277001357 RNA binding site [nucleotide binding]; other site 745277001358 Sm2 motif; other site 745277001359 GTPase HflX; Provisional; Region: PRK11058 745277001360 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 745277001361 HflX GTPase family; Region: HflX; cd01878 745277001362 G1 box; other site 745277001363 GTP/Mg2+ binding site [chemical binding]; other site 745277001364 Switch I region; other site 745277001365 G2 box; other site 745277001366 G3 box; other site 745277001367 Switch II region; other site 745277001368 G4 box; other site 745277001369 G5 box; other site 745277001370 FtsH protease regulator HflK; Provisional; Region: PRK10930 745277001371 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 745277001372 High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflK; cd03404 745277001373 HflC protein; Region: hflC; TIGR01932 745277001374 High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflC; cd03405 745277001375 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 745277001376 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 745277001377 GDP-binding site [chemical binding]; other site 745277001378 ACT binding site; other site 745277001379 IMP binding site; other site 745277001380 transcriptional repressor NsrR; Provisional; Region: PRK11014 745277001381 Rrf2 family protein; Region: rrf2_super; TIGR00738 745277001382 exoribonuclease R; Provisional; Region: PRK11642 745277001383 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 745277001384 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 745277001385 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 745277001386 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 745277001387 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 745277001388 RNA binding site [nucleotide binding]; other site 745277001389 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 745277001390 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 745277001391 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 745277001392 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 745277001393 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 745277001394 active site 745277001395 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 745277001396 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 745277001397 dimerization interface [polypeptide binding]; other site 745277001398 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 745277001399 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 745277001400 dimer interface [polypeptide binding]; other site 745277001401 putative CheW interface [polypeptide binding]; other site 745277001402 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 745277001403 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 745277001404 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 745277001405 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 745277001406 dimer interface [polypeptide binding]; other site 745277001407 ssDNA binding site [nucleotide binding]; other site 745277001408 tetramer (dimer of dimers) interface [polypeptide binding]; other site 745277001409 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 745277001410 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 745277001411 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 745277001412 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 745277001413 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 745277001414 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 745277001415 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 745277001416 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 745277001417 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 745277001418 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 745277001419 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 745277001420 Hemerythrin-like domain; Region: Hr-like; cd12108 745277001421 Fe binding site [ion binding]; other site 745277001422 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 745277001423 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 745277001424 active site 745277001425 metal binding site [ion binding]; metal-binding site 745277001426 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 745277001427 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 745277001428 active site 745277001429 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398 745277001430 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 745277001431 Domain of unknown function DUF21; Region: DUF21; pfam01595 745277001432 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 745277001433 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 745277001434 Transporter associated domain; Region: CorC_HlyC; smart01091 745277001435 methionine sulfoxide reductase A; Provisional; Region: PRK00058 745277001436 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 745277001437 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 745277001438 Surface antigen; Region: Bac_surface_Ag; pfam01103 745277001439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 745277001440 Family of unknown function (DUF490); Region: DUF490; pfam04357 745277001441 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 745277001442 putative active site pocket [active] 745277001443 dimerization interface [polypeptide binding]; other site 745277001444 putative catalytic residue [active] 745277001445 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 745277001446 dimer interface [polypeptide binding]; other site 745277001447 substrate binding site [chemical binding]; other site 745277001448 metal binding sites [ion binding]; metal-binding site 745277001449 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 745277001450 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 745277001451 dimer interface [polypeptide binding]; other site 745277001452 ligand binding site [chemical binding]; other site 745277001453 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 745277001454 dimerization interface [polypeptide binding]; other site 745277001455 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 745277001456 dimer interface [polypeptide binding]; other site 745277001457 putative CheW interface [polypeptide binding]; other site 745277001458 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 745277001459 AMP binding site [chemical binding]; other site 745277001460 metal binding site [ion binding]; metal-binding site 745277001461 active site 745277001462 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 745277001463 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 745277001464 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 745277001465 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 745277001466 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 745277001467 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 745277001468 arginine repressor; Provisional; Region: PRK05066 745277001469 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 745277001470 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 745277001471 malate dehydrogenase; Provisional; Region: PRK05086 745277001472 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 745277001473 NAD binding site [chemical binding]; other site 745277001474 dimerization interface [polypeptide binding]; other site 745277001475 Substrate binding site [chemical binding]; other site 745277001476 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 745277001477 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 745277001478 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 745277001479 substrate binding pocket [chemical binding]; other site 745277001480 chain length determination region; other site 745277001481 substrate-Mg2+ binding site; other site 745277001482 catalytic residues [active] 745277001483 aspartate-rich region 1; other site 745277001484 active site lid residues [active] 745277001485 aspartate-rich region 2; other site 745277001486 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 745277001487 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 745277001488 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 745277001489 EamA-like transporter family; Region: EamA; pfam00892 745277001490 EamA-like transporter family; Region: EamA; pfam00892 745277001491 GTPase CgtA; Reviewed; Region: obgE; PRK12298 745277001492 GTP1/OBG; Region: GTP1_OBG; pfam01018 745277001493 Obg GTPase; Region: Obg; cd01898 745277001494 G1 box; other site 745277001495 GTP/Mg2+ binding site [chemical binding]; other site 745277001496 Switch I region; other site 745277001497 G2 box; other site 745277001498 G3 box; other site 745277001499 Switch II region; other site 745277001500 G4 box; other site 745277001501 G5 box; other site 745277001502 sensor protein BasS/PmrB; Provisional; Region: PRK10755 745277001503 HAMP domain; Region: HAMP; pfam00672 745277001504 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745277001505 dimer interface [polypeptide binding]; other site 745277001506 phosphorylation site [posttranslational modification] 745277001507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277001508 ATP binding site [chemical binding]; other site 745277001509 Mg2+ binding site [ion binding]; other site 745277001510 G-X-G motif; other site 745277001511 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 745277001512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277001513 active site 745277001514 phosphorylation site [posttranslational modification] 745277001515 intermolecular recognition site; other site 745277001516 dimerization interface [polypeptide binding]; other site 745277001517 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 745277001518 DNA binding site [nucleotide binding] 745277001519 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 745277001520 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 745277001521 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 745277001522 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 745277001523 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 745277001524 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 745277001525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277001526 S-adenosylmethionine binding site [chemical binding]; other site 745277001527 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 745277001528 FtsH Extracellular; Region: FtsH_ext; pfam06480 745277001529 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745277001530 Walker A motif; other site 745277001531 ATP binding site [chemical binding]; other site 745277001532 Walker B motif; other site 745277001533 arginine finger; other site 745277001534 Peptidase family M41; Region: Peptidase_M41; pfam01434 745277001535 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 745277001536 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 745277001537 substrate binding pocket [chemical binding]; other site 745277001538 dimer interface [polypeptide binding]; other site 745277001539 inhibitor binding site; inhibition site 745277001540 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 745277001541 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 745277001542 active site 745277001543 substrate binding site [chemical binding]; other site 745277001544 metal binding site [ion binding]; metal-binding site 745277001545 Preprotein translocase SecG subunit; Region: SecG; pfam03840 745277001546 Sm and related proteins; Region: Sm_like; cl00259 745277001547 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 745277001548 putative oligomer interface [polypeptide binding]; other site 745277001549 putative RNA binding site [nucleotide binding]; other site 745277001550 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 745277001551 NusA N-terminal domain; Region: NusA_N; pfam08529 745277001552 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 745277001553 RNA binding site [nucleotide binding]; other site 745277001554 homodimer interface [polypeptide binding]; other site 745277001555 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 745277001556 G-X-X-G motif; other site 745277001557 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 745277001558 G-X-X-G motif; other site 745277001559 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 745277001560 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 745277001561 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 745277001562 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 745277001563 Protein of unknown function (DUF1178); Region: DUF1178; cl17833 745277001564 translation initiation factor IF-2; Validated; Region: infB; PRK05306 745277001565 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 745277001566 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 745277001567 G1 box; other site 745277001568 putative GEF interaction site [polypeptide binding]; other site 745277001569 GTP/Mg2+ binding site [chemical binding]; other site 745277001570 Switch I region; other site 745277001571 G2 box; other site 745277001572 G3 box; other site 745277001573 Switch II region; other site 745277001574 G4 box; other site 745277001575 G5 box; other site 745277001576 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 745277001577 Translation-initiation factor 2; Region: IF-2; pfam11987 745277001578 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 745277001579 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 745277001580 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 745277001581 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 745277001582 RNA binding site [nucleotide binding]; other site 745277001583 active site 745277001584 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 745277001585 ribosomal S15 leader; IMG reference gene:2506707542 745277001586 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 745277001587 16S/18S rRNA binding site [nucleotide binding]; other site 745277001588 S13e-L30e interaction site [polypeptide binding]; other site 745277001589 25S rRNA binding site [nucleotide binding]; other site 745277001590 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 745277001591 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 745277001592 RNase E interface [polypeptide binding]; other site 745277001593 trimer interface [polypeptide binding]; other site 745277001594 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 745277001595 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 745277001596 RNase E interface [polypeptide binding]; other site 745277001597 trimer interface [polypeptide binding]; other site 745277001598 active site 745277001599 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 745277001600 putative nucleic acid binding region [nucleotide binding]; other site 745277001601 G-X-X-G motif; other site 745277001602 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 745277001603 RNA binding site [nucleotide binding]; other site 745277001604 domain interface; other site 745277001605 lipoprotein NlpI; Provisional; Region: PRK11189 745277001606 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 745277001607 binding surface 745277001608 TPR motif; other site 745277001609 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 745277001610 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 745277001611 ATP binding site [chemical binding]; other site 745277001612 Mg++ binding site [ion binding]; other site 745277001613 motif III; other site 745277001614 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 745277001615 nucleotide binding region [chemical binding]; other site 745277001616 ATP-binding site [chemical binding]; other site 745277001617 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 745277001618 putative RNA binding site [nucleotide binding]; other site 745277001619 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 745277001620 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 745277001621 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 745277001622 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 745277001623 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 745277001624 HlyD family secretion protein; Region: HlyD_3; pfam13437 745277001625 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 745277001626 ABC-2 type transporter; Region: ABC2_membrane; cl17235 745277001627 ABC-2 type transporter; Region: ABC2_membrane; cl17235 745277001628 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 745277001629 putative protease; Provisional; Region: PRK15447 745277001630 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 745277001631 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 745277001632 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 745277001633 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745277001634 Coenzyme A binding pocket [chemical binding]; other site 745277001635 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 745277001636 GIY-YIG motif/motif A; other site 745277001637 putative active site [active] 745277001638 putative metal binding site [ion binding]; other site 745277001639 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3787; cl17897 745277001640 intracellular protease, PfpI family; Region: PfpI; TIGR01382 745277001641 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 745277001642 proposed catalytic triad [active] 745277001643 conserved cys residue [active] 745277001644 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 745277001645 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745277001646 NAD(P) binding site [chemical binding]; other site 745277001647 active site 745277001648 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 745277001649 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 745277001650 trimer interface [polypeptide binding]; other site 745277001651 active site 745277001652 substrate binding site [chemical binding]; other site 745277001653 CoA binding site [chemical binding]; other site 745277001654 Guanylate kinase; Region: Guanylate_kin; pfam00625 745277001655 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 745277001656 active site 745277001657 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 745277001658 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 745277001659 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 745277001660 active site 745277001661 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 745277001662 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745277001663 Walker A/P-loop; other site 745277001664 ATP binding site [chemical binding]; other site 745277001665 Q-loop/lid; other site 745277001666 ABC transporter signature motif; other site 745277001667 Walker B; other site 745277001668 D-loop; other site 745277001669 H-loop/switch region; other site 745277001670 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 745277001671 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277001672 Walker A/P-loop; other site 745277001673 ATP binding site [chemical binding]; other site 745277001674 Q-loop/lid; other site 745277001675 ABC transporter signature motif; other site 745277001676 Walker B; other site 745277001677 D-loop; other site 745277001678 H-loop/switch region; other site 745277001679 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745277001680 Phosphonate metabolizm protein PhnJ; Region: PhnJ; pfam06007 745277001681 Bacterial phosphonate metabolizm protein (PhnI); Region: PhnI; pfam05861 745277001682 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 745277001683 Phosphonate metabolizm protein PhnG; Region: PhnG; pfam06754 745277001684 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 745277001685 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745277001686 DNA-binding site [nucleotide binding]; DNA binding site 745277001687 UTRA domain; Region: UTRA; pfam07702 745277001688 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 745277001689 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 745277001690 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 745277001691 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 745277001692 PapC N-terminal domain; Region: PapC_N; pfam13954 745277001693 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 745277001694 Outer membrane usher protein; Region: Usher; pfam00577 745277001695 PapC C-terminal domain; Region: PapC_C; pfam13953 745277001696 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 745277001697 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 745277001698 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 745277001699 haemagglutination activity domain; Region: Haemagg_act; pfam05860 745277001700 BDLF3; Provisional; Region: PHA03255 745277001701 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 745277001702 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 745277001703 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 745277001704 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 745277001705 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; PRK11121 745277001706 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 745277001707 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 745277001708 ATP cone domain; Region: ATP-cone; pfam03477 745277001709 Class III ribonucleotide reductase; Region: RNR_III; cd01675 745277001710 effector binding site; other site 745277001711 active site 745277001712 Zn binding site [ion binding]; other site 745277001713 glycine loop; other site 745277001714 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 745277001715 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 745277001716 Ca binding site [ion binding]; other site 745277001717 active site 745277001718 catalytic site [active] 745277001719 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 745277001720 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 745277001721 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 745277001722 active site turn [active] 745277001723 phosphorylation site [posttranslational modification] 745277001724 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 745277001725 trehalose repressor; Provisional; Region: treR; PRK09492 745277001726 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745277001727 DNA binding site [nucleotide binding] 745277001728 domain linker motif; other site 745277001729 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 745277001730 dimerization interface [polypeptide binding]; other site 745277001731 ligand binding site [chemical binding]; other site 745277001732 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 745277001733 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 745277001734 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 745277001735 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 745277001736 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745277001737 motif II; other site 745277001738 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 745277001739 Transposase IS200 like; Region: Y1_Tnp; pfam01797 745277001740 serine/threonine transporter SstT; Provisional; Region: PRK13628 745277001741 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 745277001742 yybP-ykoY leader; IMG reference gene:2506707589 745277001743 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 745277001744 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 745277001745 catalytic triad [active] 745277001746 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 745277001747 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 745277001748 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 745277001749 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 745277001750 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 745277001751 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277001752 S-adenosylmethionine binding site [chemical binding]; other site 745277001753 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 745277001754 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 745277001755 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 745277001756 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 745277001757 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 745277001758 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 745277001759 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 745277001760 PAAR motif; Region: PAAR_motif; pfam05488 745277001761 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 745277001762 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 745277001763 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 745277001764 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 745277001765 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 745277001766 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 745277001767 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 745277001768 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 745277001769 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 745277001770 active site 745277001771 FMN binding site [chemical binding]; other site 745277001772 2,4-decadienoyl-CoA binding site; other site 745277001773 catalytic residue [active] 745277001774 4Fe-4S cluster binding site [ion binding]; other site 745277001775 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 745277001776 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 745277001777 substrate binding site [chemical binding]; other site 745277001778 oxyanion hole (OAH) forming residues; other site 745277001779 trimer interface [polypeptide binding]; other site 745277001780 RNase II stability modulator; Provisional; Region: PRK10060 745277001781 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 745277001782 putative active site [active] 745277001783 heme pocket [chemical binding]; other site 745277001784 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745277001785 metal binding site [ion binding]; metal-binding site 745277001786 active site 745277001787 I-site; other site 745277001788 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 745277001789 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 745277001790 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 745277001791 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 745277001792 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 745277001793 transcriptional regulator MalT; Provisional; Region: PRK04841 745277001794 AAA ATPase domain; Region: AAA_16; pfam13191 745277001795 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 745277001796 DNA binding residues [nucleotide binding] 745277001797 dimerization interface [polypeptide binding]; other site 745277001798 maltodextrin phosphorylase; Provisional; Region: PRK14985 745277001799 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 745277001800 active site pocket [active] 745277001801 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 745277001802 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 745277001803 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745277001804 non-specific DNA binding site [nucleotide binding]; other site 745277001805 salt bridge; other site 745277001806 sequence-specific DNA binding site [nucleotide binding]; other site 745277001807 HipA-like N-terminal domain; Region: HipA_N; pfam07805 745277001808 HipA-like C-terminal domain; Region: HipA_C; pfam07804 745277001809 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 745277001810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277001811 dimer interface [polypeptide binding]; other site 745277001812 conserved gate region; other site 745277001813 putative PBP binding loops; other site 745277001814 ABC-ATPase subunit interface; other site 745277001815 maltose transporter membrane protein; Provisional; Region: malF; PRK10999 745277001816 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 745277001817 Maltose transport system permease protein MalF P2 domain; Region: MalF_P2; pfam14785 745277001818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277001819 dimer interface [polypeptide binding]; other site 745277001820 conserved gate region; other site 745277001821 putative PBP binding loops; other site 745277001822 ABC-ATPase subunit interface; other site 745277001823 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 745277001824 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 745277001825 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 745277001826 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 745277001827 Walker A/P-loop; other site 745277001828 ATP binding site [chemical binding]; other site 745277001829 Q-loop/lid; other site 745277001830 ABC transporter signature motif; other site 745277001831 Walker B; other site 745277001832 D-loop; other site 745277001833 H-loop/switch region; other site 745277001834 TOBE domain; Region: TOBE_2; pfam08402 745277001835 maltoporin; Provisional; Region: lamB; PRK09360 745277001836 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 745277001837 trimer interface; other site 745277001838 sugar binding site [chemical binding]; other site 745277001839 maltose regulon periplasmic protein; Provisional; Region: PRK10564 745277001840 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 745277001841 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 745277001842 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277001843 Helix-turn-helix domain; Region: HTH_18; pfam12833 745277001844 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 745277001845 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 745277001846 active site 745277001847 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 745277001848 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 745277001849 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 745277001850 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 745277001851 DNA binding site [nucleotide binding] 745277001852 active site 745277001853 glutamate dehydrogenase; Provisional; Region: PRK09414 745277001854 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 745277001855 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 745277001856 NAD(P) binding site [chemical binding]; other site 745277001857 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 745277001858 CoA binding domain; Region: CoA_binding; cl17356 745277001859 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 745277001860 NAD(P) binding site [chemical binding]; other site 745277001861 homodimer interface [polypeptide binding]; other site 745277001862 substrate binding site [chemical binding]; other site 745277001863 active site 745277001864 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 745277001865 Mg++ binding site [ion binding]; other site 745277001866 putative catalytic motif [active] 745277001867 putative substrate binding site [chemical binding]; other site 745277001868 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 745277001869 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 745277001870 putative NAD(P) binding site [chemical binding]; other site 745277001871 active site 745277001872 putative substrate binding site [chemical binding]; other site 745277001873 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 745277001874 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 745277001875 putative ADP-binding pocket [chemical binding]; other site 745277001876 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745277001877 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 745277001878 NAD(P) binding site [chemical binding]; other site 745277001879 active site 745277001880 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 745277001881 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 745277001882 NADP-binding site; other site 745277001883 homotetramer interface [polypeptide binding]; other site 745277001884 substrate binding site [chemical binding]; other site 745277001885 homodimer interface [polypeptide binding]; other site 745277001886 active site 745277001887 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 745277001888 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 745277001889 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 745277001890 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 745277001891 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 745277001892 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 745277001893 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 745277001894 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 745277001895 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 745277001896 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 745277001897 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 745277001898 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 745277001899 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 745277001900 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 745277001901 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 745277001902 catalytic core [active] 745277001903 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 745277001904 Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138 745277001905 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 745277001906 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 745277001907 putative homodimer interface [polypeptide binding]; other site 745277001908 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 745277001909 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 745277001910 active site 745277001911 homodimer interface [polypeptide binding]; other site 745277001912 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 745277001913 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 745277001914 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 745277001915 acyl-activating enzyme (AAE) consensus motif; other site 745277001916 active site 745277001917 AMP binding site [chemical binding]; other site 745277001918 CoA binding site [chemical binding]; other site 745277001919 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 745277001920 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 745277001921 Walker A/P-loop; other site 745277001922 ATP binding site [chemical binding]; other site 745277001923 Q-loop/lid; other site 745277001924 ABC transporter signature motif; other site 745277001925 Walker B; other site 745277001926 D-loop; other site 745277001927 H-loop/switch region; other site 745277001928 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 745277001929 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 745277001930 phosphomannomutase CpsG; Provisional; Region: PRK15414 745277001931 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 745277001932 active site 745277001933 substrate binding site [chemical binding]; other site 745277001934 metal binding site [ion binding]; metal-binding site 745277001935 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 745277001936 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 745277001937 Substrate binding site; other site 745277001938 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 745277001939 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 745277001940 active site 745277001941 SUMO-1 interface [polypeptide binding]; other site 745277001942 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 745277001943 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 745277001944 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 745277001945 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 745277001946 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 745277001947 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 745277001948 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 745277001949 DNA binding residues [nucleotide binding] 745277001950 DNA primase; Validated; Region: dnaG; PRK05667 745277001951 CHC2 zinc finger; Region: zf-CHC2; pfam01807 745277001952 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 745277001953 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 745277001954 active site 745277001955 metal binding site [ion binding]; metal-binding site 745277001956 interdomain interaction site; other site 745277001957 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 745277001958 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 745277001959 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 745277001960 UGMP family protein; Validated; Region: PRK09604 745277001961 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 745277001962 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 745277001963 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 745277001964 homooctamer interface [polypeptide binding]; other site 745277001965 active site 745277001966 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 745277001967 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 745277001968 Poly A polymerase head domain; Region: PolyA_pol; pfam01743 745277001969 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 745277001970 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 745277001971 Zn2+ binding site [ion binding]; other site 745277001972 Mg2+ binding site [ion binding]; other site 745277001973 SH3 domain-containing protein; Provisional; Region: PRK10884 745277001974 Bacterial SH3 domain homologues; Region: SH3b; smart00287 745277001975 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 745277001976 Uncharacterized conserved protein [Function unknown]; Region: COG3025 745277001977 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 745277001978 putative active site [active] 745277001979 putative metal binding residues [ion binding]; other site 745277001980 signature motif; other site 745277001981 putative triphosphate binding site [ion binding]; other site 745277001982 CHAD domain; Region: CHAD; pfam05235 745277001983 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 745277001984 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 745277001985 metal binding triad; other site 745277001986 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 745277001987 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 745277001988 metal binding triad; other site 745277001989 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; cl19627 745277001990 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 745277001991 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 745277001992 putative ribose interaction site [chemical binding]; other site 745277001993 putative ADP binding site [chemical binding]; other site 745277001994 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 745277001995 active site 745277001996 nucleotide binding site [chemical binding]; other site 745277001997 HIGH motif; other site 745277001998 KMSKS motif; other site 745277001999 putative transporter; Provisional; Region: PRK11021 745277002000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 745277002001 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 745277002002 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 745277002003 putative active site [active] 745277002004 metal binding site [ion binding]; metal-binding site 745277002005 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 745277002006 hypothetical protein; Provisional; Region: PRK11653 745277002007 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 745277002008 Outer membrane efflux protein; Region: OEP; pfam02321 745277002009 Outer membrane efflux protein; Region: OEP; pfam02321 745277002010 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 745277002011 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 745277002012 dimer interface [polypeptide binding]; other site 745277002013 ADP-ribose binding site [chemical binding]; other site 745277002014 active site 745277002015 nudix motif; other site 745277002016 metal binding site [ion binding]; metal-binding site 745277002017 putative dehydrogenase; Provisional; Region: PRK11039 745277002018 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 745277002019 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 745277002020 active site 745277002021 metal binding site [ion binding]; metal-binding site 745277002022 hexamer interface [polypeptide binding]; other site 745277002023 esterase YqiA; Provisional; Region: PRK11071 745277002024 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 745277002025 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 745277002026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277002027 ATP binding site [chemical binding]; other site 745277002028 Mg2+ binding site [ion binding]; other site 745277002029 G-X-G motif; other site 745277002030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 745277002031 anchoring element; other site 745277002032 dimer interface [polypeptide binding]; other site 745277002033 ATP binding site [chemical binding]; other site 745277002034 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 745277002035 active site 745277002036 metal binding site [ion binding]; metal-binding site 745277002037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 745277002038 Uncharacterized conserved protein [Function unknown]; Region: COG1359 745277002039 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 745277002040 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 745277002041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 745277002042 CAP-like domain; other site 745277002043 active site 745277002044 primary dimer interface [polypeptide binding]; other site 745277002045 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 745277002046 putative acyl-acceptor binding pocket; other site 745277002047 FtsI repressor; Provisional; Region: PRK10883 745277002048 Cupredoxin superfamily; Region: Cupredoxin; cl19115 745277002049 The second Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_2_CueO_FtsP; cd13867 745277002050 Domain 1 interface [polypeptide binding]; other site 745277002051 Domain 3 interface [polypeptide binding]; other site 745277002052 Cupredoxin superfamily; Region: Cupredoxin; cl19115 745277002053 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 745277002054 active site 745277002055 catalytic tetrad [active] 745277002056 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 745277002057 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 745277002058 putative NAD(P) binding site [chemical binding]; other site 745277002059 putative substrate binding site [chemical binding]; other site 745277002060 catalytic Zn binding site [ion binding]; other site 745277002061 structural Zn binding site [ion binding]; other site 745277002062 dimer interface [polypeptide binding]; other site 745277002063 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 745277002064 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 745277002065 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277002066 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277002067 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 745277002068 cystathionine beta-lyase; Provisional; Region: PRK08114 745277002069 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 745277002070 catalytic residue [active] 745277002071 DctM-like transporters; Region: DctM; pfam06808 745277002072 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 745277002073 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 745277002074 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 745277002075 biopolymer transport protein ExbB; Provisional; Region: PRK10414 745277002076 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 745277002077 galactarate dehydratase; Region: galactar-dH20; TIGR03248 745277002078 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 745277002079 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 745277002080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277002081 D-galactonate transporter; Region: 2A0114; TIGR00893 745277002082 putative substrate translocation pore; other site 745277002083 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 745277002084 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 745277002085 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 745277002086 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 745277002087 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 745277002088 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 745277002089 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 745277002090 dimer interface [polypeptide binding]; other site 745277002091 active site 745277002092 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 745277002093 substrate binding site [chemical binding]; other site 745277002094 catalytic residue [active] 745277002095 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 745277002096 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 745277002097 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 745277002098 dimerization interface [polypeptide binding]; other site 745277002099 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745277002100 dimer interface [polypeptide binding]; other site 745277002101 phosphorylation site [posttranslational modification] 745277002102 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277002103 ATP binding site [chemical binding]; other site 745277002104 Mg2+ binding site [ion binding]; other site 745277002105 G-X-G motif; other site 745277002106 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 745277002107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277002108 active site 745277002109 phosphorylation site [posttranslational modification] 745277002110 intermolecular recognition site; other site 745277002111 dimerization interface [polypeptide binding]; other site 745277002112 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 745277002113 putative binding surface; other site 745277002114 active site 745277002115 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 745277002116 TRAM domain; Region: TRAM; pfam01938 745277002117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277002118 S-adenosylmethionine binding site [chemical binding]; other site 745277002119 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 745277002120 HD domain; Region: HD_4; pfam13328 745277002121 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 745277002122 synthetase active site [active] 745277002123 NTP binding site [chemical binding]; other site 745277002124 metal binding site [ion binding]; metal-binding site 745277002125 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 745277002126 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 745277002127 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 745277002128 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 745277002129 homodimer interface [polypeptide binding]; other site 745277002130 metal binding site [ion binding]; metal-binding site 745277002131 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 745277002132 homodimer interface [polypeptide binding]; other site 745277002133 active site 745277002134 putative chemical substrate binding site [chemical binding]; other site 745277002135 metal binding site [ion binding]; metal-binding site 745277002136 CTP synthetase; Validated; Region: pyrG; PRK05380 745277002137 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 745277002138 Catalytic site [active] 745277002139 active site 745277002140 UTP binding site [chemical binding]; other site 745277002141 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 745277002142 active site 745277002143 putative oxyanion hole; other site 745277002144 catalytic triad [active] 745277002145 enolase; Provisional; Region: eno; PRK00077 745277002146 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 745277002147 dimer interface [polypeptide binding]; other site 745277002148 metal binding site [ion binding]; metal-binding site 745277002149 substrate binding pocket [chemical binding]; other site 745277002150 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 745277002151 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 745277002152 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 745277002153 active site 745277002154 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 745277002155 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 745277002156 Flavodoxin; Region: Flavodoxin_1; pfam00258 745277002157 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 745277002158 FAD binding pocket [chemical binding]; other site 745277002159 FAD binding motif [chemical binding]; other site 745277002160 catalytic residues [active] 745277002161 NAD binding pocket [chemical binding]; other site 745277002162 phosphate binding motif [ion binding]; other site 745277002163 beta-alpha-beta structure motif; other site 745277002164 sulfite reductase subunit beta; Provisional; Region: PRK13504 745277002165 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 745277002166 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 745277002167 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 745277002168 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 745277002169 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 745277002170 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 745277002171 Active Sites [active] 745277002172 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 745277002173 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 745277002174 metal binding site [ion binding]; metal-binding site 745277002175 siroheme synthase; Provisional; Region: cysG; PRK10637 745277002176 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 745277002177 Sirohaem synthase dimerization region; Region: CysG_dimeriser; pfam10414 745277002178 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 745277002179 active site 745277002180 SAM binding site [chemical binding]; other site 745277002181 homodimer interface [polypeptide binding]; other site 745277002182 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 745277002183 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 745277002184 Active Sites [active] 745277002185 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 745277002186 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 745277002187 CysD dimerization site [polypeptide binding]; other site 745277002188 G1 box; other site 745277002189 putative GEF interaction site [polypeptide binding]; other site 745277002190 GTP/Mg2+ binding site [chemical binding]; other site 745277002191 Switch I region; other site 745277002192 G2 box; other site 745277002193 G3 box; other site 745277002194 Switch II region; other site 745277002195 G4 box; other site 745277002196 G5 box; other site 745277002197 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 745277002198 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 745277002199 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 745277002200 ligand-binding site [chemical binding]; other site 745277002201 hypothetical protein; Provisional; Region: PRK10726 745277002202 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 745277002203 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 745277002204 substrate binding site; other site 745277002205 dimer interface; other site 745277002206 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 745277002207 homotrimer interaction site [polypeptide binding]; other site 745277002208 zinc binding site [ion binding]; other site 745277002209 CDP-binding sites; other site 745277002210 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 745277002211 Permutation of conserved domain; other site 745277002212 active site 745277002213 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 745277002214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277002215 S-adenosylmethionine binding site [chemical binding]; other site 745277002216 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 745277002217 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 745277002218 Peptidase family M23; Region: Peptidase_M23; pfam01551 745277002219 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 745277002220 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 745277002221 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 745277002222 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 745277002223 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 745277002224 DNA binding residues [nucleotide binding] 745277002225 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 745277002226 MutS domain I; Region: MutS_I; pfam01624 745277002227 MutS domain II; Region: MutS_II; pfam05188 745277002228 MutS domain III; Region: MutS_III; pfam05192 745277002229 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 745277002230 Walker A/P-loop; other site 745277002231 ATP binding site [chemical binding]; other site 745277002232 Q-loop/lid; other site 745277002233 ABC transporter signature motif; other site 745277002234 Walker B; other site 745277002235 D-loop; other site 745277002236 H-loop/switch region; other site 745277002237 Fimbrial protein; Region: Fimbrial; cl01416 745277002238 putative chaperone protein EcpD; Provisional; Region: PRK09926 745277002239 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 745277002240 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 745277002241 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 745277002242 PapC N-terminal domain; Region: PapC_N; pfam13954 745277002243 Outer membrane usher protein; Region: Usher; pfam00577 745277002244 PapC C-terminal domain; Region: PapC_C; pfam13953 745277002245 putative fimbrial protein StaE; Provisional; Region: PRK15263 745277002246 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 745277002247 Fimbrial protein; Region: Fimbrial; pfam00419 745277002248 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 745277002249 Fimbrial protein; Region: Fimbrial; pfam00419 745277002250 murein hydrolase B; Provisional; Region: PRK10760 745277002251 putative lipoprotein; Provisional; Region: PRK10533 745277002252 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 745277002253 N-acetyl-D-glucosamine binding site [chemical binding]; other site 745277002254 catalytic residue [active] 745277002255 hypothetical protein; Validated; Region: PRK03661 745277002256 recombinase A; Provisional; Region: recA; PRK09354 745277002257 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 745277002258 hexamer interface [polypeptide binding]; other site 745277002259 Walker A motif; other site 745277002260 ATP binding site [chemical binding]; other site 745277002261 Walker B motif; other site 745277002262 recombination regulator RecX; Reviewed; Region: recX; PRK00117 745277002263 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 745277002264 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 745277002265 motif 1; other site 745277002266 active site 745277002267 motif 2; other site 745277002268 motif 3; other site 745277002269 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 745277002270 DHHA1 domain; Region: DHHA1; pfam02272 745277002271 carbon storage regulator; Provisional; Region: PRK01712 745277002272 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 745277002273 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745277002274 motif II; other site 745277002275 Predicted membrane protein [Function unknown]; Region: COG1238 745277002276 glutamate--cysteine ligase; Provisional; Region: PRK02107 745277002277 S-ribosylhomocysteinase; Provisional; Region: PRK02260 745277002278 hypothetical protein; Provisional; Region: PRK11573 745277002279 Domain of unknown function DUF21; Region: DUF21; pfam01595 745277002280 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 745277002281 Transporter associated domain; Region: CorC_HlyC; smart01091 745277002282 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 745277002283 signal recognition particle protein; Provisional; Region: PRK10867 745277002284 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 745277002285 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 745277002286 P loop; other site 745277002287 GTP binding site [chemical binding]; other site 745277002288 Signal peptide binding domain; Region: SRP_SPB; pfam02978 745277002289 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 745277002290 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 745277002291 RimM N-terminal domain; Region: RimM; pfam01782 745277002292 PRC-barrel domain; Region: PRC; pfam05239 745277002293 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 745277002294 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 745277002295 Ogr/Delta-like zinc finger; Region: Ogr_Delta; cl19592 745277002296 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 745277002297 Phage P2 GpU; Region: Phage_P2_GpU; cl01391 745277002298 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 745277002299 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 745277002300 Protein of unknown function (DUF1576); Region: DUF1576; pfam07613 745277002301 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 745277002302 major tail tube protein; Provisional; Region: FII; PHA02600 745277002303 major tail sheath protein; Provisional; Region: FI; PHA02560 745277002304 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 745277002305 Phage Tail Collar Domain; Region: Collar; pfam07484 745277002306 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 745277002307 baseplate assembly protein; Provisional; Region: J; PHA02568 745277002308 baseplate wedge subunit; Provisional; Region: W; PHA02516 745277002309 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 745277002310 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 745277002311 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 745277002312 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 745277002313 catalytic residues [active] 745277002314 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 745277002315 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 745277002316 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 745277002317 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 745277002318 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 745277002319 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 745277002320 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 745277002321 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 745277002322 Chorismate mutase type II; Region: CM_2; cl00693 745277002323 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 745277002324 prephenate dehydrogenase; Validated; Region: PRK08507 745277002325 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 745277002326 Chorismate mutase type II; Region: CM_2; cl00693 745277002327 Prephenate dehydratase; Region: PDT; pfam00800 745277002328 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 745277002329 putative L-Phe binding site [chemical binding]; other site 745277002330 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 745277002331 30S subunit binding site; other site 745277002332 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 745277002333 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 745277002334 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 745277002335 RNA binding surface [nucleotide binding]; other site 745277002336 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 745277002337 active site 745277002338 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 745277002339 protein disaggregation chaperone; Provisional; Region: PRK10865 745277002340 Clp amino terminal domain; Region: Clp_N; pfam02861 745277002341 Clp amino terminal domain; Region: Clp_N; pfam02861 745277002342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745277002343 Walker A motif; other site 745277002344 ATP binding site [chemical binding]; other site 745277002345 Walker B motif; other site 745277002346 arginine finger; other site 745277002347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745277002348 Walker A motif; other site 745277002349 ATP binding site [chemical binding]; other site 745277002350 Walker B motif; other site 745277002351 arginine finger; other site 745277002352 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 745277002353 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 745277002354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277002355 putative substrate translocation pore; other site 745277002356 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 745277002357 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 745277002358 domain interface [polypeptide binding]; other site 745277002359 putative active site [active] 745277002360 catalytic site [active] 745277002361 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 745277002362 domain interface [polypeptide binding]; other site 745277002363 putative active site [active] 745277002364 catalytic site [active] 745277002365 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 745277002366 CoA binding domain; Region: CoA_binding_2; pfam13380 745277002367 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 745277002368 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 745277002369 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 745277002370 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745277002371 Coenzyme A binding pocket [chemical binding]; other site 745277002372 Uncharacterized conserved protein [Function unknown]; Region: COG3148 745277002373 thioredoxin 2; Provisional; Region: PRK10996 745277002374 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 745277002375 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 745277002376 catalytic residues [active] 745277002377 putative methyltransferase; Provisional; Region: PRK10864 745277002378 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 745277002379 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 745277002380 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 745277002381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277002382 putative substrate translocation pore; other site 745277002383 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 745277002384 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 745277002385 HlyD family secretion protein; Region: HlyD_3; pfam13437 745277002386 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 745277002387 Outer membrane efflux protein; Region: OEP; pfam02321 745277002388 Outer membrane efflux protein; Region: OEP; pfam02321 745277002389 transcriptional repressor MprA; Provisional; Region: PRK10870 745277002390 Transcriptional regulators [Transcription]; Region: MarR; COG1846 745277002391 putative L-valine exporter; Provisional; Region: PRK10408 745277002392 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 745277002393 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 745277002394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277002395 putative substrate translocation pore; other site 745277002396 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 745277002397 YcfA-like protein; Region: YcfA; pfam07927 745277002398 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 745277002399 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 745277002400 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 745277002401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277002402 dimer interface [polypeptide binding]; other site 745277002403 conserved gate region; other site 745277002404 putative PBP binding loops; other site 745277002405 ABC-ATPase subunit interface; other site 745277002406 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 745277002407 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 745277002408 Walker A/P-loop; other site 745277002409 ATP binding site [chemical binding]; other site 745277002410 Q-loop/lid; other site 745277002411 ABC transporter signature motif; other site 745277002412 Walker B; other site 745277002413 D-loop; other site 745277002414 H-loop/switch region; other site 745277002415 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 745277002416 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 745277002417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277002418 active site 745277002419 phosphorylation site [posttranslational modification] 745277002420 intermolecular recognition site; other site 745277002421 dimerization interface [polypeptide binding]; other site 745277002422 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 745277002423 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 745277002424 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 745277002425 putative active site [active] 745277002426 heme pocket [chemical binding]; other site 745277002427 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 745277002428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277002429 ATP binding site [chemical binding]; other site 745277002430 Mg2+ binding site [ion binding]; other site 745277002431 G-X-G motif; other site 745277002432 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 745277002433 NlpC/P60 family; Region: NLPC_P60; pfam00877 745277002434 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 745277002435 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 745277002436 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 745277002437 active site 745277002438 catalytic tetrad [active] 745277002439 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 745277002440 dimer interface [polypeptide binding]; other site 745277002441 putative radical transfer pathway; other site 745277002442 diiron center [ion binding]; other site 745277002443 tyrosyl radical; other site 745277002444 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 745277002445 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 745277002446 Class I ribonucleotide reductase; Region: RNR_I; cd01679 745277002447 active site 745277002448 dimer interface [polypeptide binding]; other site 745277002449 catalytic residues [active] 745277002450 effector binding site; other site 745277002451 R2 peptide binding site; other site 745277002452 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 745277002453 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 745277002454 catalytic residues [active] 745277002455 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 745277002456 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745277002457 DNA-binding site [nucleotide binding]; DNA binding site 745277002458 UTRA domain; Region: UTRA; pfam07702 745277002459 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 745277002460 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 745277002461 active site 745277002462 phosphorylation site [posttranslational modification] 745277002463 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 745277002464 active site 745277002465 P-loop; other site 745277002466 phosphorylation site [posttranslational modification] 745277002467 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 745277002468 alpha-mannosidase; Provisional; Region: PRK09819 745277002469 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 745277002470 active site 745277002471 metal binding site [ion binding]; metal-binding site 745277002472 catalytic site [active] 745277002473 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 745277002474 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 745277002475 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 745277002476 major facilitator superfamily transporter; Provisional; Region: PRK05122 745277002477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277002478 putative substrate translocation pore; other site 745277002479 hypothetical protein; Provisional; Region: PRK10556 745277002480 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 745277002481 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 745277002482 putative active site [active] 745277002483 putative metal binding residues [ion binding]; other site 745277002484 signature motif; other site 745277002485 putative triphosphate binding site [ion binding]; other site 745277002486 dimer interface [polypeptide binding]; other site 745277002487 putative global regulator; Reviewed; Region: PRK09559 745277002488 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 745277002489 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 745277002490 hypothetical protein; Provisional; Region: PRK10878 745277002491 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 745277002492 flavodoxin FldB; Provisional; Region: PRK12359 745277002493 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 745277002494 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 745277002495 active site 745277002496 Int/Topo IB signature motif; other site 745277002497 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 745277002498 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 745277002499 dimerization domain [polypeptide binding]; other site 745277002500 dimer interface [polypeptide binding]; other site 745277002501 catalytic residues [active] 745277002502 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 745277002503 DHH family; Region: DHH; pfam01368 745277002504 DHHA1 domain; Region: DHHA1; pfam02272 745277002505 peptide chain release factor 2; Validated; Region: prfB; PRK00578 745277002506 This domain is found in peptide chain release factors; Region: PCRF; smart00937 745277002507 RF-1 domain; Region: RF-1; pfam00472 745277002508 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 745277002509 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 745277002510 dimer interface [polypeptide binding]; other site 745277002511 putative anticodon binding site; other site 745277002512 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 745277002513 motif 1; other site 745277002514 active site 745277002515 motif 2; other site 745277002516 motif 3; other site 745277002517 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 745277002518 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 745277002519 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 745277002520 catalytic residues [active] 745277002521 catalytic nucleophile [active] 745277002522 Presynaptic Site I dimer interface [polypeptide binding]; other site 745277002523 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 745277002524 Synaptic Flat tetramer interface [polypeptide binding]; other site 745277002525 Synaptic Site I dimer interface [polypeptide binding]; other site 745277002526 DNA binding site [nucleotide binding] 745277002527 Homeodomain-like domain; Region: HTH_23; pfam13384 745277002528 HNH endonuclease; Region: HNH_3; pfam13392 745277002529 putative NHN endonuclease; Region: PHA00280 745277002530 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 745277002531 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 745277002532 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 745277002533 active site 745277002534 DNA binding site [nucleotide binding] 745277002535 Int/Topo IB signature motif; other site 745277002536 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 745277002537 argininosuccinate synthase; Validated; Region: PRK05370 745277002538 NIPSNAP; Region: NIPSNAP; pfam07978 745277002539 putative arabinose transporter; Provisional; Region: PRK03545 745277002540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277002541 putative substrate translocation pore; other site 745277002542 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 745277002543 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 745277002544 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 745277002545 catalytic triad [active] 745277002546 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 745277002547 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 745277002548 HlyD family secretion protein; Region: HlyD_3; pfam13437 745277002549 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 745277002550 MMPL family; Region: MMPL; cl14618 745277002551 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 745277002552 MMPL family; Region: MMPL; cl14618 745277002553 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 745277002554 Outer membrane efflux protein; Region: OEP; pfam02321 745277002555 Outer membrane efflux protein; Region: OEP; pfam02321 745277002556 Protein of unknown function (DUF796); Region: DUF796; cl01226 745277002557 RelB antitoxin; Region: RelB; cl01171 745277002558 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 745277002559 Outer membrane efflux protein; Region: OEP; pfam02321 745277002560 Outer membrane efflux protein; Region: OEP; pfam02321 745277002561 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 745277002562 MMPL family; Region: MMPL; cl14618 745277002563 MMPL family; Region: MMPL; cl14618 745277002564 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 745277002565 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 745277002566 HlyD family secretion protein; Region: HlyD_3; pfam13437 745277002567 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 745277002568 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 745277002569 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 745277002570 active site turn [active] 745277002571 phosphorylation site [posttranslational modification] 745277002572 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 745277002573 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745277002574 DNA-binding site [nucleotide binding]; DNA binding site 745277002575 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 745277002576 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 745277002577 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 745277002578 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 745277002579 Tetratricopeptide repeat; Region: TPR_12; pfam13424 745277002580 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 745277002581 transcriptional activator TtdR; Provisional; Region: PRK09801 745277002582 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277002583 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 745277002584 putative effector binding pocket; other site 745277002585 dimerization interface [polypeptide binding]; other site 745277002586 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 745277002587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277002588 putative substrate translocation pore; other site 745277002589 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 745277002590 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277002591 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 745277002592 dimerization interface [polypeptide binding]; other site 745277002593 diaminopimelate decarboxylase; Provisional; Region: PRK11165 745277002594 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 745277002595 active site 745277002596 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 745277002597 substrate binding site [chemical binding]; other site 745277002598 catalytic residues [active] 745277002599 dimer interface [polypeptide binding]; other site 745277002600 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 745277002601 methionine cluster; other site 745277002602 active site 745277002603 phosphorylation site [posttranslational modification] 745277002604 metal binding site [ion binding]; metal-binding site 745277002605 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 745277002606 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 745277002607 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 745277002608 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 745277002609 active site 745277002610 P-loop; other site 745277002611 phosphorylation site [posttranslational modification] 745277002612 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 745277002613 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745277002614 DNA-binding site [nucleotide binding]; DNA binding site 745277002615 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 745277002616 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 745277002617 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745277002618 Coenzyme A binding pocket [chemical binding]; other site 745277002619 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 745277002620 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745277002621 DNA binding site [nucleotide binding] 745277002622 domain linker motif; other site 745277002623 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 745277002624 dimerization interface (closed form) [polypeptide binding]; other site 745277002625 ligand binding site [chemical binding]; other site 745277002626 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277002627 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277002628 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 745277002629 putative effector binding pocket; other site 745277002630 dimerization interface [polypeptide binding]; other site 745277002631 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 745277002632 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745277002633 substrate binding pocket [chemical binding]; other site 745277002634 membrane-bound complex binding site; other site 745277002635 hinge residues; other site 745277002636 2OG-Fe dioxygenase; Region: 2OG-Fe_Oxy_2; pfam10014 745277002637 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 745277002638 classical (c) SDRs; Region: SDR_c; cd05233 745277002639 NAD(P) binding site [chemical binding]; other site 745277002640 active site 745277002641 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 745277002642 H+ Antiporter protein; Region: 2A0121; TIGR00900 745277002643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277002644 putative substrate translocation pore; other site 745277002645 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 745277002646 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 745277002647 molybdopterin cofactor binding site [chemical binding]; other site 745277002648 substrate binding site [chemical binding]; other site 745277002649 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 745277002650 molybdopterin cofactor binding site; other site 745277002651 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 745277002652 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 745277002653 putative acyl-acceptor binding pocket; other site 745277002654 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 745277002655 acyl-activating enzyme (AAE) consensus motif; other site 745277002656 putative AMP binding site [chemical binding]; other site 745277002657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277002658 Major Facilitator Superfamily; Region: MFS_1; pfam07690 745277002659 putative substrate translocation pore; other site 745277002660 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 745277002661 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 745277002662 active site 745277002663 catalytic tetrad [active] 745277002664 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 745277002665 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 745277002666 putative DNA-binding cleft [nucleotide binding]; other site 745277002667 putative DNA clevage site; other site 745277002668 molecular lever; other site 745277002669 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 745277002670 putative active site [active] 745277002671 Ap4A binding site [chemical binding]; other site 745277002672 nudix motif; other site 745277002673 putative metal binding site [ion binding]; other site 745277002674 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 745277002675 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 745277002676 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 745277002677 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 745277002678 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 745277002679 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 745277002680 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 745277002681 dimerization interface [polypeptide binding]; other site 745277002682 active site 745277002683 hypothetical protein; Provisional; Region: PRK10506 745277002684 hypothetical protein; Provisional; Region: PRK10557 745277002685 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 745277002686 Protein of unknown function (DUF2509); Region: DUF2509; cl11672 745277002687 Prepilin peptidase dependent protein C (DUF3728); Region: DUF3728; cl19725 745277002688 protease3; Provisional; Region: PRK15101 745277002689 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 745277002690 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 745277002691 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 745277002692 N-acetylglutamate synthase; Validated; Region: PRK05279 745277002693 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 745277002694 putative feedback inhibition sensing region; other site 745277002695 putative nucleotide binding site [chemical binding]; other site 745277002696 putative substrate binding site [chemical binding]; other site 745277002697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745277002698 Coenzyme A binding pocket [chemical binding]; other site 745277002699 AMIN domain; Region: AMIN; pfam11741 745277002700 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 745277002701 active site 745277002702 metal binding site [ion binding]; metal-binding site 745277002703 murein transglycosylase A; Provisional; Region: mltA; PRK11162 745277002704 MltA specific insert domain; Region: MltA; smart00925 745277002705 3D domain; Region: 3D; pfam06725 745277002706 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 745277002707 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 745277002708 putative ATP binding site [chemical binding]; other site 745277002709 putative substrate interface [chemical binding]; other site 745277002710 Fe-S metabolizm associated domain; Region: SufE; cl00951 745277002711 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 745277002712 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 745277002713 catalytic residue [active] 745277002714 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 745277002715 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 745277002716 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277002717 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 745277002718 dimerization interface [polypeptide binding]; other site 745277002719 substrate binding pocket [chemical binding]; other site 745277002720 hypothetical protein; Provisional; Region: PRK10873 745277002721 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 745277002722 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 745277002723 flap endonuclease-like protein; Provisional; Region: PRK09482 745277002724 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 745277002725 active site 745277002726 metal binding site 1 [ion binding]; metal-binding site 745277002727 putative 5' ssDNA interaction site; other site 745277002728 metal binding site 3; metal-binding site 745277002729 metal binding site 2 [ion binding]; metal-binding site 745277002730 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 745277002731 putative DNA binding site [nucleotide binding]; other site 745277002732 putative metal binding site [ion binding]; other site 745277002733 Domain of unknown function (DUF4478); Region: DUF4478; pfam14793 745277002734 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 745277002735 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 745277002736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 745277002737 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 745277002738 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 745277002739 SecY interacting protein Syd; Provisional; Region: PRK04968 745277002740 benzoate transport; Region: 2A0115; TIGR00895 745277002741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277002742 putative substrate translocation pore; other site 745277002743 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 745277002744 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 745277002745 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 745277002746 probable active site [active] 745277002747 flavodoxin; Provisional; Region: PRK08105 745277002748 hypothetical protein; Provisional; Region: PRK13677 745277002749 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 745277002750 Tetrahydrodipicolinate N-succinyltransferase N-terminal; Region: THDPS_N_2; pfam14805 745277002751 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 745277002752 trimer interface [polypeptide binding]; other site 745277002753 active site 745277002754 substrate binding site [chemical binding]; other site 745277002755 CoA binding site [chemical binding]; other site 745277002756 PII uridylyl-transferase; Provisional; Region: PRK05007 745277002757 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 745277002758 metal binding triad; other site 745277002759 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 745277002760 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 745277002761 Zn2+ binding site [ion binding]; other site 745277002762 Mg2+ binding site [ion binding]; other site 745277002763 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 745277002764 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 745277002765 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 745277002766 active site 745277002767 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 745277002768 rRNA interaction site [nucleotide binding]; other site 745277002769 S8 interaction site; other site 745277002770 putative laminin-1 binding site; other site 745277002771 elongation factor Ts; Provisional; Region: tsf; PRK09377 745277002772 UBA/TS-N domain; Region: UBA; pfam00627 745277002773 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 745277002774 putative nucleotide binding site [chemical binding]; other site 745277002775 uridine monophosphate binding site [chemical binding]; other site 745277002776 homohexameric interface [polypeptide binding]; other site 745277002777 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 745277002778 hinge region; other site 745277002779 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 745277002780 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 745277002781 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 745277002782 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 745277002783 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 745277002784 active site 745277002785 dimer interface [polypeptide binding]; other site 745277002786 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 745277002787 zinc metallopeptidase RseP; Provisional; Region: PRK10779 745277002788 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 745277002789 active site 745277002790 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 745277002791 protein binding site [polypeptide binding]; other site 745277002792 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 745277002793 putative substrate binding region [chemical binding]; other site 745277002794 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 745277002795 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 745277002796 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 745277002797 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 745277002798 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 745277002799 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 745277002800 Surface antigen; Region: Bac_surface_Ag; pfam01103 745277002801 periplasmic chaperone; Provisional; Region: PRK10780 745277002802 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 745277002803 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 745277002804 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 745277002805 trimer interface [polypeptide binding]; other site 745277002806 active site 745277002807 UDP-GlcNAc binding site [chemical binding]; other site 745277002808 lipid binding site [chemical binding]; lipid-binding site 745277002809 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 745277002810 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 745277002811 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 745277002812 active site 745277002813 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 745277002814 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 745277002815 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 745277002816 RNA/DNA hybrid binding site [nucleotide binding]; other site 745277002817 active site 745277002818 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 745277002819 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 745277002820 putative active site [active] 745277002821 putative PHP Thumb interface [polypeptide binding]; other site 745277002822 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 745277002823 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 745277002824 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 745277002825 generic binding surface II; other site 745277002826 generic binding surface I; other site 745277002827 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 745277002828 lysine decarboxylase LdcC; Provisional; Region: PRK15399 745277002829 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 745277002830 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 745277002831 homodimer interface [polypeptide binding]; other site 745277002832 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277002833 catalytic residue [active] 745277002834 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 745277002835 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 745277002836 putative metal binding site [ion binding]; other site 745277002837 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 745277002838 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 745277002839 Ligand Binding Site [chemical binding]; other site 745277002840 TilS substrate binding domain; Region: TilS; pfam09179 745277002841 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 745277002842 Cytochrome c553 [Energy production and conversion]; Region: COG2863 745277002843 Rho-binding antiterminator; Provisional; Region: PRK11625 745277002844 hypothetical protein; Provisional; Region: PRK04964 745277002845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 745277002846 hypothetical protein; Provisional; Region: PRK09256 745277002847 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 745277002848 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 745277002849 NlpE N-terminal domain; Region: NlpE; cl19736 745277002850 prolyl-tRNA synthetase; Provisional; Region: PRK09194 745277002851 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 745277002852 dimer interface [polypeptide binding]; other site 745277002853 motif 1; other site 745277002854 active site 745277002855 motif 2; other site 745277002856 motif 3; other site 745277002857 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 745277002858 anticodon binding site; other site 745277002859 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 745277002860 homodimer interaction site [polypeptide binding]; other site 745277002861 cofactor binding site; other site 745277002862 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 745277002863 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 745277002864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277002865 dimer interface [polypeptide binding]; other site 745277002866 conserved gate region; other site 745277002867 ABC-ATPase subunit interface; other site 745277002868 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 745277002869 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 745277002870 Walker A/P-loop; other site 745277002871 ATP binding site [chemical binding]; other site 745277002872 Q-loop/lid; other site 745277002873 ABC transporter signature motif; other site 745277002874 Walker B; other site 745277002875 D-loop; other site 745277002876 H-loop/switch region; other site 745277002877 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 745277002878 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 745277002879 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745277002880 active site 745277002881 motif I; other site 745277002882 motif II; other site 745277002883 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 745277002884 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 745277002885 putative acyl-acceptor binding pocket; other site 745277002886 Phosphopantetheine attachment site; Region: PP-binding; cl09936 745277002887 acyl carrier protein; Provisional; Region: PRK05350 745277002888 Predicted membrane protein [Function unknown]; Region: COG4648 745277002889 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 745277002890 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 745277002891 acyl-activating enzyme (AAE) consensus motif; other site 745277002892 AMP binding site [chemical binding]; other site 745277002893 active site 745277002894 CoA binding site [chemical binding]; other site 745277002895 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 745277002896 active site 2 [active] 745277002897 active site 1 [active] 745277002898 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 745277002899 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 745277002900 Ligand binding site; other site 745277002901 Putative Catalytic site; other site 745277002902 DXD motif; other site 745277002903 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 745277002904 putative acyl-acceptor binding pocket; other site 745277002905 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 745277002906 active site 745277002907 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl19192 745277002908 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl19192 745277002909 Predicted exporter [General function prediction only]; Region: COG4258 745277002910 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 745277002911 MMPL family; Region: MMPL; cl14618 745277002912 MMPL family; Region: MMPL; cl14618 745277002913 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 745277002914 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 745277002915 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 745277002916 dimer interface [polypeptide binding]; other site 745277002917 active site 745277002918 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 745277002919 putative active site 1 [active] 745277002920 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745277002921 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 745277002922 NAD(P) binding site [chemical binding]; other site 745277002923 active site 745277002924 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 745277002925 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 745277002926 dimer interface [polypeptide binding]; other site 745277002927 active site 745277002928 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 745277002929 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 745277002930 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277002931 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277002932 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 745277002933 dimerization interface [polypeptide binding]; other site 745277002934 hypothetical protein; Provisional; Region: PRK05421 745277002935 putative catalytic site [active] 745277002936 putative metal binding site [ion binding]; other site 745277002937 putative catalytic site [active] 745277002938 putative phosphate binding site [ion binding]; other site 745277002939 putative phosphate binding site [ion binding]; other site 745277002940 putative metal binding site [ion binding]; other site 745277002941 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 745277002942 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 745277002943 N-acetyl-D-glucosamine binding site [chemical binding]; other site 745277002944 catalytic residue [active] 745277002945 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 745277002946 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 745277002947 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 745277002948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277002949 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 745277002950 RNA/DNA hybrid binding site [nucleotide binding]; other site 745277002951 active site 745277002952 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 745277002953 putative active site; other site 745277002954 catalytic triad [active] 745277002955 putative dimer interface [polypeptide binding]; other site 745277002956 agmatine deiminase; Provisional; Region: PRK13551 745277002957 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 745277002958 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 745277002959 active site 745277002960 catalytic site [active] 745277002961 substrate binding site [chemical binding]; other site 745277002962 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 745277002963 Na binding site [ion binding]; other site 745277002964 putative substrate binding site [chemical binding]; other site 745277002965 Transcriptional regulators [Transcription]; Region: FadR; COG2186 745277002966 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745277002967 DNA-binding site [nucleotide binding]; DNA binding site 745277002968 FCD domain; Region: FCD; pfam07729 745277002969 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 745277002970 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 745277002971 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 745277002972 active site 745277002973 catalytic site [active] 745277002974 tetramer interface [polypeptide binding]; other site 745277002975 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 745277002976 amidase; Provisional; Region: PRK09201 745277002977 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 745277002978 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 745277002979 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 745277002980 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 745277002981 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 745277002982 putative active site [active] 745277002983 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 745277002984 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745277002985 substrate binding pocket [chemical binding]; other site 745277002986 membrane-bound complex binding site; other site 745277002987 hinge residues; other site 745277002988 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 745277002989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277002990 dimer interface [polypeptide binding]; other site 745277002991 conserved gate region; other site 745277002992 putative PBP binding loops; other site 745277002993 ABC-ATPase subunit interface; other site 745277002994 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 745277002995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277002996 dimer interface [polypeptide binding]; other site 745277002997 conserved gate region; other site 745277002998 putative PBP binding loops; other site 745277002999 ABC-ATPase subunit interface; other site 745277003000 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 745277003001 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 745277003002 Walker A/P-loop; other site 745277003003 ATP binding site [chemical binding]; other site 745277003004 Q-loop/lid; other site 745277003005 ABC transporter signature motif; other site 745277003006 Walker B; other site 745277003007 D-loop; other site 745277003008 H-loop/switch region; other site 745277003009 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 745277003010 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 745277003011 catalytic residue [active] 745277003012 allantoate amidohydrolase; Reviewed; Region: PRK09290 745277003013 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 745277003014 active site 745277003015 metal binding site [ion binding]; metal-binding site 745277003016 dimer interface [polypeptide binding]; other site 745277003017 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 745277003018 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 745277003019 active site 745277003020 homotetramer interface [polypeptide binding]; other site 745277003021 hypothetical protein; Validated; Region: PRK06186 745277003022 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 745277003023 conserved cys residue [active] 745277003024 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 745277003025 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 745277003026 putative active site [active] 745277003027 catalytic triad [active] 745277003028 dimer interface [polypeptide binding]; other site 745277003029 multimer interface [polypeptide binding]; other site 745277003030 methionine aminotransferase; Validated; Region: PRK09082 745277003031 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 745277003032 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277003033 homodimer interface [polypeptide binding]; other site 745277003034 catalytic residue [active] 745277003035 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 745277003036 intersubunit interface [polypeptide binding]; other site 745277003037 active site 745277003038 Zn2+ binding site [ion binding]; other site 745277003039 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 745277003040 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 745277003041 Cupin domain; Region: Cupin_2; cl17218 745277003042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380 745277003043 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 745277003044 Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462 745277003045 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 745277003046 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 745277003047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 745277003048 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 745277003049 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 745277003050 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 745277003051 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 745277003052 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 745277003053 active site 745277003054 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 745277003055 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 745277003056 dimer interface [polypeptide binding]; other site 745277003057 active site 745277003058 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 745277003059 putative active site [active] 745277003060 Glutamine amidotransferases class-II; Region: GATase_2; pfam00310 745277003061 putative dimer interface [polypeptide binding]; other site 745277003062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 745277003063 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 745277003064 active site 745277003065 DNA polymerase IV; Validated; Region: PRK02406 745277003066 DNA binding site [nucleotide binding] 745277003067 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 745277003068 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 745277003069 metal binding site [ion binding]; metal-binding site 745277003070 dimer interface [polypeptide binding]; other site 745277003071 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 745277003072 active site 745277003073 Putative lysophospholipase; Region: Hydrolase_4; cl19140 745277003074 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 745277003075 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 745277003076 gamma-glutamyl kinase; Provisional; Region: PRK05429 745277003077 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 745277003078 nucleotide binding site [chemical binding]; other site 745277003079 homotetrameric interface [polypeptide binding]; other site 745277003080 putative phosphate binding site [ion binding]; other site 745277003081 putative allosteric binding site; other site 745277003082 PUA domain; Region: PUA; pfam01472 745277003083 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 745277003084 putative catalytic cysteine [active] 745277003085 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277003086 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277003087 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 745277003088 putative effector binding pocket; other site 745277003089 putative dimerization interface [polypeptide binding]; other site 745277003090 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 745277003091 Putative lysophospholipase; Region: Hydrolase_4; cl19140 745277003092 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 745277003093 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 745277003094 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 745277003095 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 745277003096 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745277003097 non-specific DNA binding site [nucleotide binding]; other site 745277003098 salt bridge; other site 745277003099 sequence-specific DNA binding site [nucleotide binding]; other site 745277003100 Bacterial self-protective colicin-like immunity; Region: Colicin_immun; pfam09204 745277003101 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 745277003102 PAAR motif; Region: PAAR_motif; cl15808 745277003103 PAAR motif; Region: PAAR_motif; pfam05488 745277003104 S-type Pyocin; Region: Pyocin_S; pfam06958 745277003105 Cytotoxic; Region: Cytotoxic; pfam09000 745277003106 Cloacin immunity protein; Region: Cloacin_immun; pfam03513 745277003107 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 745277003108 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 745277003109 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 745277003110 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 745277003111 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 745277003112 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 745277003113 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 745277003114 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 745277003115 catalytic loop [active] 745277003116 iron binding site [ion binding]; other site 745277003117 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 745277003118 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 745277003119 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 745277003120 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745277003121 non-specific DNA binding site [nucleotide binding]; other site 745277003122 salt bridge; other site 745277003123 sequence-specific DNA binding site [nucleotide binding]; other site 745277003124 Domain of unknown function (DUF955); Region: DUF955; cl01076 745277003125 Cupin; Region: Cupin_6; pfam12852 745277003126 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 745277003127 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277003128 short chain dehydrogenase; Provisional; Region: PRK06180 745277003129 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 745277003130 NADP binding site [chemical binding]; other site 745277003131 active site 745277003132 steroid binding site; other site 745277003133 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 745277003134 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 745277003135 metal binding site [ion binding]; metal-binding site 745277003136 putative dimer interface [polypeptide binding]; other site 745277003137 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 745277003138 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 745277003139 trimer interface [polypeptide binding]; other site 745277003140 active site 745277003141 substrate binding site [chemical binding]; other site 745277003142 CoA binding site [chemical binding]; other site 745277003143 Cache domain; Region: Cache_1; pfam02743 745277003144 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 745277003145 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 745277003146 dimerization interface [polypeptide binding]; other site 745277003147 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 745277003148 dimer interface [polypeptide binding]; other site 745277003149 putative CheW interface [polypeptide binding]; other site 745277003150 Rdx family; Region: Rdx; cl01407 745277003151 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 745277003152 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 745277003153 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 745277003154 Part of AAA domain; Region: AAA_19; pfam13245 745277003155 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 745277003156 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 745277003157 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 745277003158 AAA domain; Region: AAA_30; pfam13604 745277003159 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 745277003160 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 745277003161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277003162 putative substrate translocation pore; other site 745277003163 Beta-lactamase; Region: Beta-lactamase; pfam00144 745277003164 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277003165 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277003166 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 745277003167 putative effector binding pocket; other site 745277003168 putative dimerization interface [polypeptide binding]; other site 745277003169 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745277003170 Coenzyme A binding pocket [chemical binding]; other site 745277003171 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 745277003172 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745277003173 non-specific DNA binding site [nucleotide binding]; other site 745277003174 salt bridge; other site 745277003175 sequence-specific DNA binding site [nucleotide binding]; other site 745277003176 2TM domain; Region: 2TM; pfam13239 745277003177 HAMP domain; Region: HAMP; pfam00672 745277003178 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745277003179 metal binding site [ion binding]; metal-binding site 745277003180 active site 745277003181 I-site; other site 745277003182 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 745277003183 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 745277003184 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 745277003185 DNA-binding site [nucleotide binding]; DNA binding site 745277003186 RNA-binding motif; other site 745277003187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277003188 D-galactonate transporter; Region: 2A0114; TIGR00893 745277003189 putative substrate translocation pore; other site 745277003190 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 745277003191 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 745277003192 active site 745277003193 tetramer interface [polypeptide binding]; other site 745277003194 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 745277003195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277003196 putative substrate translocation pore; other site 745277003197 Putative lysophospholipase; Region: Hydrolase_4; cl19140 745277003198 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 745277003199 penicillin-binding protein 2; Provisional; Region: PRK10795 745277003200 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 745277003201 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 745277003202 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 745277003203 HAMP domain; Region: HAMP; pfam00672 745277003204 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745277003205 dimer interface [polypeptide binding]; other site 745277003206 phosphorylation site [posttranslational modification] 745277003207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277003208 ATP binding site [chemical binding]; other site 745277003209 Mg2+ binding site [ion binding]; other site 745277003210 G-X-G motif; other site 745277003211 hypothetical protein; Provisional; Region: PRK10722 745277003212 response regulator GlrR; Provisional; Region: PRK15115 745277003213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277003214 active site 745277003215 phosphorylation site [posttranslational modification] 745277003216 intermolecular recognition site; other site 745277003217 dimerization interface [polypeptide binding]; other site 745277003218 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745277003219 Walker A motif; other site 745277003220 ATP binding site [chemical binding]; other site 745277003221 Walker B motif; other site 745277003222 arginine finger; other site 745277003223 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 745277003224 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 745277003225 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 745277003226 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 745277003227 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 745277003228 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 745277003229 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 745277003230 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 745277003231 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 745277003232 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 745277003233 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 745277003234 heme-binding site [chemical binding]; other site 745277003235 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 745277003236 FAD binding pocket [chemical binding]; other site 745277003237 FAD binding motif [chemical binding]; other site 745277003238 phosphate binding motif [ion binding]; other site 745277003239 beta-alpha-beta structure motif; other site 745277003240 NAD binding pocket [chemical binding]; other site 745277003241 Heme binding pocket [chemical binding]; other site 745277003242 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 745277003243 dimer interface [polypeptide binding]; other site 745277003244 active site 745277003245 glycine-pyridoxal phosphate binding site [chemical binding]; other site 745277003246 folate binding site [chemical binding]; other site 745277003247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277003248 sugar efflux transporter; Region: 2A0120; TIGR00899 745277003249 putative substrate translocation pore; other site 745277003250 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 745277003251 PRD domain; Region: PRD; pfam00874 745277003252 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 745277003253 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 745277003254 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 745277003255 active site 745277003256 dimerization interface [polypeptide binding]; other site 745277003257 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 745277003258 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 745277003259 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 745277003260 Rrf2 family protein; Region: rrf2_super; TIGR00738 745277003261 cysteine desulfurase; Provisional; Region: PRK14012 745277003262 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 745277003263 catalytic residue [active] 745277003264 aminopeptidase B; Provisional; Region: PRK05015 745277003265 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 745277003266 interface (dimer of trimers) [polypeptide binding]; other site 745277003267 Substrate-binding/catalytic site; other site 745277003268 Zn-binding sites [ion binding]; other site 745277003269 SseB protein N-terminal domain; Region: SseB; pfam07179 745277003270 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 745277003271 SseB protein C-terminal domain; Region: SseB_C; pfam14581 745277003272 Nucleoside diphosphate kinase; Region: NDK; pfam00334 745277003273 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 745277003274 active site 745277003275 multimer interface [polypeptide binding]; other site 745277003276 23S rRNA m2A2503 methyltransferase; Region: TIGR00048 745277003277 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 745277003278 FeS/SAM binding site; other site 745277003279 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 745277003280 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 745277003281 binding surface 745277003282 TPR motif; other site 745277003283 cytoskeletal protein RodZ; Provisional; Region: PRK10856 745277003284 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745277003285 non-specific DNA binding site [nucleotide binding]; other site 745277003286 salt bridge; other site 745277003287 sequence-specific DNA binding site [nucleotide binding]; other site 745277003288 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 745277003289 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 745277003290 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 745277003291 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 745277003292 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 745277003293 dimer interface [polypeptide binding]; other site 745277003294 motif 1; other site 745277003295 active site 745277003296 motif 2; other site 745277003297 motif 3; other site 745277003298 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 745277003299 anticodon binding site; other site 745277003300 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 745277003301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 745277003302 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 745277003303 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 745277003304 Trp docking motif [polypeptide binding]; other site 745277003305 GTP-binding protein Der; Reviewed; Region: PRK00093 745277003306 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 745277003307 G1 box; other site 745277003308 GTP/Mg2+ binding site [chemical binding]; other site 745277003309 Switch I region; other site 745277003310 G2 box; other site 745277003311 Switch II region; other site 745277003312 G3 box; other site 745277003313 G4 box; other site 745277003314 G5 box; other site 745277003315 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 745277003316 G1 box; other site 745277003317 GTP/Mg2+ binding site [chemical binding]; other site 745277003318 Switch I region; other site 745277003319 G2 box; other site 745277003320 G3 box; other site 745277003321 Switch II region; other site 745277003322 G4 box; other site 745277003323 G5 box; other site 745277003324 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 745277003325 Predicted permeases [General function prediction only]; Region: COG0679 745277003326 zinc-ribbons; Region: zinc-ribbons_6; pfam07191 745277003327 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 745277003328 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 745277003329 active site 745277003330 Zn binding site [ion binding]; other site 745277003331 Transcriptional regulators [Transcription]; Region: PurR; COG1609 745277003332 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745277003333 DNA binding site [nucleotide binding] 745277003334 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 745277003335 ligand binding site [chemical binding]; other site 745277003336 dimerization interface [polypeptide binding]; other site 745277003337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277003338 D-galactonate transporter; Region: 2A0114; TIGR00893 745277003339 putative substrate translocation pore; other site 745277003340 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 745277003341 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 745277003342 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 745277003343 putative active site [active] 745277003344 putative catalytic site [active] 745277003345 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 745277003346 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 745277003347 generic binding surface II; other site 745277003348 generic binding surface I; other site 745277003349 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 745277003350 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 745277003351 active site 745277003352 GMP synthase; Reviewed; Region: guaA; PRK00074 745277003353 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 745277003354 AMP/PPi binding site [chemical binding]; other site 745277003355 candidate oxyanion hole; other site 745277003356 catalytic triad [active] 745277003357 potential glutamine specificity residues [chemical binding]; other site 745277003358 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 745277003359 ATP Binding subdomain [chemical binding]; other site 745277003360 Ligand Binding sites [chemical binding]; other site 745277003361 Dimerization subdomain; other site 745277003362 PAS domain S-box; Region: sensory_box; TIGR00229 745277003363 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 745277003364 putative active site [active] 745277003365 heme pocket [chemical binding]; other site 745277003366 GAF domain; Region: GAF_2; pfam13185 745277003367 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745277003368 metal binding site [ion binding]; metal-binding site 745277003369 active site 745277003370 I-site; other site 745277003371 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 745277003372 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277003373 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277003374 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 745277003375 dimerization interface [polypeptide binding]; other site 745277003376 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 745277003377 HicB family; Region: HicB; pfam05534 745277003378 YcfA-like protein; Region: YcfA; pfam07927 745277003379 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 745277003380 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 745277003381 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745277003382 Coenzyme A binding pocket [chemical binding]; other site 745277003383 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 745277003384 substrate binding site [chemical binding]; other site 745277003385 multimerization interface [polypeptide binding]; other site 745277003386 ATP binding site [chemical binding]; other site 745277003387 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 745277003388 dimer interface [polypeptide binding]; other site 745277003389 substrate binding site [chemical binding]; other site 745277003390 ATP binding site [chemical binding]; other site 745277003391 Transcriptional regulators [Transcription]; Region: GntR; COG1802 745277003392 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745277003393 DNA-binding site [nucleotide binding]; DNA binding site 745277003394 FCD domain; Region: FCD; pfam07729 745277003395 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 745277003396 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 745277003397 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277003398 putative symporter YagG; Provisional; Region: PRK09669; cl15392 745277003399 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 745277003400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 745277003401 Chorismate mutase type II; Region: CM_2; cl00693 745277003402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277003403 D-galactonate transporter; Region: 2A0114; TIGR00893 745277003404 putative substrate translocation pore; other site 745277003405 putative oxidoreductase; Provisional; Region: PRK10083 745277003406 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 745277003407 putative NAD(P) binding site [chemical binding]; other site 745277003408 catalytic Zn binding site [ion binding]; other site 745277003409 structural Zn binding site [ion binding]; other site 745277003410 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 745277003411 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 745277003412 putative active site pocket [active] 745277003413 putative metal binding site [ion binding]; other site 745277003414 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 745277003415 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 745277003416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277003417 putative substrate translocation pore; other site 745277003418 lipid kinase; Reviewed; Region: PRK13054 745277003419 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 745277003420 putative protease; Provisional; Region: PRK15452 745277003421 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 745277003422 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 745277003423 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 745277003424 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 745277003425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277003426 active site 745277003427 phosphorylation site [posttranslational modification] 745277003428 intermolecular recognition site; other site 745277003429 dimerization interface [polypeptide binding]; other site 745277003430 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 745277003431 DNA binding site [nucleotide binding] 745277003432 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 745277003433 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 745277003434 dimerization interface [polypeptide binding]; other site 745277003435 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745277003436 dimer interface [polypeptide binding]; other site 745277003437 phosphorylation site [posttranslational modification] 745277003438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277003439 ATP binding site [chemical binding]; other site 745277003440 Mg2+ binding site [ion binding]; other site 745277003441 G-X-G motif; other site 745277003442 putative transporter; Provisional; Region: PRK10504 745277003443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277003444 putative substrate translocation pore; other site 745277003445 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 745277003446 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 745277003447 active site 745277003448 catalytic tetrad [active] 745277003449 putative chaperone; Provisional; Region: PRK11678 745277003450 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 745277003451 nucleotide binding site [chemical binding]; other site 745277003452 putative NEF/HSP70 interaction site [polypeptide binding]; other site 745277003453 SBD interface [polypeptide binding]; other site 745277003454 transketolase; Reviewed; Region: PRK12753 745277003455 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 745277003456 TPP-binding site [chemical binding]; other site 745277003457 dimer interface [polypeptide binding]; other site 745277003458 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 745277003459 PYR/PP interface [polypeptide binding]; other site 745277003460 dimer interface [polypeptide binding]; other site 745277003461 TPP binding site [chemical binding]; other site 745277003462 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 745277003463 transaldolase-like protein; Provisional; Region: PTZ00411 745277003464 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 745277003465 active site 745277003466 dimer interface [polypeptide binding]; other site 745277003467 catalytic residue [active] 745277003468 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 745277003469 Malic enzyme, N-terminal domain; Region: malic; pfam00390 745277003470 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 745277003471 putative NAD(P) binding site [chemical binding]; other site 745277003472 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 745277003473 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 745277003474 active site 745277003475 tetramer interface [polypeptide binding]; other site 745277003476 hypothetical protein; Validated; Region: PRK00124 745277003477 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 745277003478 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 745277003479 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 745277003480 active site 745277003481 metal binding site [ion binding]; metal-binding site 745277003482 putative acetyltransferase; Provisional; Region: PRK03624 745277003483 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745277003484 Coenzyme A binding pocket [chemical binding]; other site 745277003485 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 745277003486 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 745277003487 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 745277003488 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 745277003489 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 745277003490 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 745277003491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277003492 dimer interface [polypeptide binding]; other site 745277003493 conserved gate region; other site 745277003494 putative PBP binding loops; other site 745277003495 ABC-ATPase subunit interface; other site 745277003496 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 745277003497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277003498 dimer interface [polypeptide binding]; other site 745277003499 conserved gate region; other site 745277003500 putative PBP binding loops; other site 745277003501 ABC-ATPase subunit interface; other site 745277003502 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 745277003503 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 745277003504 Walker A/P-loop; other site 745277003505 ATP binding site [chemical binding]; other site 745277003506 Q-loop/lid; other site 745277003507 ABC transporter signature motif; other site 745277003508 Walker B; other site 745277003509 D-loop; other site 745277003510 H-loop/switch region; other site 745277003511 TOBE-like domain; Region: TOBE_3; pfam12857 745277003512 cysteine synthase; Region: PLN02565 745277003513 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 745277003514 dimer interface [polypeptide binding]; other site 745277003515 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277003516 catalytic residue [active] 745277003517 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 745277003518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277003519 active site 745277003520 phosphorylation site [posttranslational modification] 745277003521 intermolecular recognition site; other site 745277003522 dimerization interface [polypeptide binding]; other site 745277003523 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 745277003524 DNA binding site [nucleotide binding] 745277003525 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 745277003526 dimerization interface [polypeptide binding]; other site 745277003527 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745277003528 dimer interface [polypeptide binding]; other site 745277003529 phosphorylation site [posttranslational modification] 745277003530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277003531 ATP binding site [chemical binding]; other site 745277003532 Mg2+ binding site [ion binding]; other site 745277003533 G-X-G motif; other site 745277003534 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 745277003535 HPr interaction site; other site 745277003536 glycerol kinase (GK) interaction site [polypeptide binding]; other site 745277003537 active site 745277003538 phosphorylation site [posttranslational modification] 745277003539 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 745277003540 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 745277003541 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 745277003542 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 745277003543 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 745277003544 dimerization domain swap beta strand [polypeptide binding]; other site 745277003545 regulatory protein interface [polypeptide binding]; other site 745277003546 active site 745277003547 regulatory phosphorylation site [posttranslational modification]; other site 745277003548 cysteine synthase; Region: PLN02565 745277003549 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 745277003550 dimer interface [polypeptide binding]; other site 745277003551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277003552 catalytic residue [active] 745277003553 putative sulfate transport protein CysZ; Validated; Region: PRK04949 745277003554 cell division protein ZipA; Provisional; Region: PRK03427 745277003555 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 745277003556 FtsZ protein binding site [polypeptide binding]; other site 745277003557 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 745277003558 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 745277003559 nucleotide binding pocket [chemical binding]; other site 745277003560 K-X-D-G motif; other site 745277003561 catalytic site [active] 745277003562 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 745277003563 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 745277003564 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 745277003565 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 745277003566 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 745277003567 Dimer interface [polypeptide binding]; other site 745277003568 BRCT sequence motif; other site 745277003569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 745277003570 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 745277003571 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277003572 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277003573 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 745277003574 putative dimerization interface [polypeptide binding]; other site 745277003575 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 745277003576 ethanolamine permease; Region: 2A0305; TIGR00908 745277003577 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 745277003578 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 745277003579 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 745277003580 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 745277003581 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 745277003582 active site 745277003583 HIGH motif; other site 745277003584 KMSKS motif; other site 745277003585 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 745277003586 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 745277003587 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 745277003588 Nucleoside recognition; Region: Gate; pfam07670 745277003589 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 745277003590 manganese transport protein MntH; Reviewed; Region: PRK00701 745277003591 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 745277003592 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 745277003593 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 745277003594 active site 745277003595 catalytic tetrad [active] 745277003596 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 745277003597 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 745277003598 dimer interface [polypeptide binding]; other site 745277003599 PYR/PP interface [polypeptide binding]; other site 745277003600 TPP binding site [chemical binding]; other site 745277003601 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 745277003602 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 745277003603 TPP-binding site [chemical binding]; other site 745277003604 dimer interface [polypeptide binding]; other site 745277003605 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277003606 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277003607 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 745277003608 dimerization interface [polypeptide binding]; other site 745277003609 Predicted membrane protein [Function unknown]; Region: COG4125 745277003610 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 745277003611 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 745277003612 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 745277003613 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 745277003614 Cl- selectivity filter; other site 745277003615 Cl- binding residues [ion binding]; other site 745277003616 pore gating glutamate residue; other site 745277003617 dimer interface [polypeptide binding]; other site 745277003618 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 745277003619 nucleotide binding site [chemical binding]; other site 745277003620 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 745277003621 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 745277003622 putative transposase OrfB; Reviewed; Region: PHA02517 745277003623 HTH-like domain; Region: HTH_21; pfam13276 745277003624 Integrase core domain; Region: rve; pfam00665 745277003625 Integrase core domain; Region: rve_2; pfam13333 745277003626 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 745277003627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277003628 active site 745277003629 phosphorylation site [posttranslational modification] 745277003630 intermolecular recognition site; other site 745277003631 dimerization interface [polypeptide binding]; other site 745277003632 LytTr DNA-binding domain; Region: LytTR; pfam04397 745277003633 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 745277003634 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 745277003635 Histidine kinase; Region: His_kinase; pfam06580 745277003636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277003637 ATP binding site [chemical binding]; other site 745277003638 Mg2+ binding site [ion binding]; other site 745277003639 G-X-G motif; other site 745277003640 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 745277003641 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745277003642 Coenzyme A binding pocket [chemical binding]; other site 745277003643 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 745277003644 aminotransferase; Validated; Region: PRK08175 745277003645 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 745277003646 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277003647 homodimer interface [polypeptide binding]; other site 745277003648 catalytic residue [active] 745277003649 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 745277003650 SnoaL-like domain; Region: SnoaL_2; pfam12680 745277003651 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 745277003652 Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; cl08082 745277003653 Curli assembly protein CsgE; Region: CsgE; cl08115 745277003654 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 745277003655 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 745277003656 DNA binding residues [nucleotide binding] 745277003657 dimerization interface [polypeptide binding]; other site 745277003658 major curlin subunit; Provisional; Region: csgA; PRK10051 745277003659 major curlin subunit; Provisional; Region: csgA; PRK10051 745277003660 Thin aggregative fimbriae synthesis protein; Region: Tafi-CsgC; cl11667 745277003661 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 745277003662 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 745277003663 Acylphosphatase; Region: Acylphosphatase; pfam00708 745277003664 HypF finger; Region: zf-HYPF; pfam07503 745277003665 HypF finger; Region: zf-HYPF; pfam07503 745277003666 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 745277003667 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 745277003668 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 745277003669 [4Fe-4S] binding site [ion binding]; other site 745277003670 molybdopterin cofactor binding site; other site 745277003671 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 745277003672 molybdopterin cofactor binding site; other site 745277003673 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 745277003674 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 745277003675 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 745277003676 nickel binding site [ion binding]; other site 745277003677 Formate hydrogenlyase maturation protein HycH; Region: HycH; pfam07450 745277003678 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 745277003679 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 745277003680 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 745277003681 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 745277003682 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 745277003683 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 745277003684 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 745277003685 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 745277003686 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 745277003687 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 745277003688 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 745277003689 Transcriptional repressor of hyc and hyp operons; Region: HycA_repressor; cl08095 745277003690 Hydrogenase expression/synthesis hypA family; Region: HypA; cl19201 745277003691 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 745277003692 HupF/HypC family; Region: HupF_HypC; cl00394 745277003693 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 745277003694 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 745277003695 dimerization interface [polypeptide binding]; other site 745277003696 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 745277003697 ATP binding site [chemical binding]; other site 745277003698 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 745277003699 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 745277003700 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 745277003701 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745277003702 Walker A motif; other site 745277003703 ATP binding site [chemical binding]; other site 745277003704 Walker B motif; other site 745277003705 arginine finger; other site 745277003706 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 745277003707 Tautomerase enzyme; Region: Tautomerase_2; pfam14552 745277003708 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 745277003709 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 745277003710 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277003711 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 745277003712 dimerization interface [polypeptide binding]; other site 745277003713 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; cl11635 745277003714 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 745277003715 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 745277003716 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 745277003717 putative S-transferase; Provisional; Region: PRK11752 745277003718 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 745277003719 C-terminal domain interface [polypeptide binding]; other site 745277003720 GSH binding site (G-site) [chemical binding]; other site 745277003721 dimer interface [polypeptide binding]; other site 745277003722 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 745277003723 dimer interface [polypeptide binding]; other site 745277003724 N-terminal domain interface [polypeptide binding]; other site 745277003725 active site 745277003726 Transcriptional regulators [Transcription]; Region: PurR; COG1609 745277003727 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745277003728 DNA binding site [nucleotide binding] 745277003729 domain linker motif; other site 745277003730 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 745277003731 ligand binding site [chemical binding]; other site 745277003732 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 745277003733 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 745277003734 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 745277003735 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 745277003736 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130 745277003737 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 745277003738 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 745277003739 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 745277003740 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 745277003741 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 745277003742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277003743 putative substrate translocation pore; other site 745277003744 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 745277003745 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745277003746 Coenzyme A binding pocket [chemical binding]; other site 745277003747 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 745277003748 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 745277003749 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 745277003750 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 745277003751 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 745277003752 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 745277003753 Walker A/P-loop; other site 745277003754 ATP binding site [chemical binding]; other site 745277003755 Q-loop/lid; other site 745277003756 ABC transporter signature motif; other site 745277003757 Walker B; other site 745277003758 D-loop; other site 745277003759 H-loop/switch region; other site 745277003760 heme exporter protein CcmB; Region: ccmB; TIGR01190 745277003761 heme exporter protein CcmC; Region: ccmC; TIGR01191 745277003762 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 745277003763 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 745277003764 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 745277003765 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 745277003766 catalytic residues [active] 745277003767 central insert; other site 745277003768 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 745277003769 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 745277003770 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 745277003771 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 745277003772 binding surface 745277003773 TPR motif; other site 745277003774 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 745277003775 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 745277003776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 745277003777 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 745277003778 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 745277003779 dimer interface [polypeptide binding]; other site 745277003780 active site 745277003781 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 745277003782 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 745277003783 substrate binding site [chemical binding]; other site 745277003784 oxyanion hole (OAH) forming residues; other site 745277003785 trimer interface [polypeptide binding]; other site 745277003786 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 745277003787 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 745277003788 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 745277003789 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 745277003790 catalytic core [active] 745277003791 hypothetical protein; Provisional; Region: PRK04946 745277003792 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 745277003793 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK11805 745277003794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277003795 S-adenosylmethionine binding site [chemical binding]; other site 745277003796 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 745277003797 Tetramer interface [polypeptide binding]; other site 745277003798 active site 745277003799 FMN-binding site [chemical binding]; other site 745277003800 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 745277003801 hypothetical protein; Provisional; Region: PRK10621 745277003802 Protein of unknown function, DUF462; Region: DUF462; cl01190 745277003803 YfcL protein; Region: YfcL; pfam08891 745277003804 Uncharacterized conserved protein [Function unknown]; Region: COG4121 745277003805 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 745277003806 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 745277003807 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 745277003808 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 745277003809 dimer interface [polypeptide binding]; other site 745277003810 active site 745277003811 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 745277003812 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 745277003813 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 745277003814 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 745277003815 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 745277003816 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 745277003817 transmembrane helices; other site 745277003818 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 745277003819 active site residue [active] 745277003820 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 745277003821 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 745277003822 EamA-like transporter family; Region: EamA; pfam00892 745277003823 EamA-like transporter family; Region: EamA; pfam00892 745277003824 Cupin domain; Region: Cupin_2; cl17218 745277003825 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277003826 Helix-turn-helix domain; Region: HTH_18; pfam12833 745277003827 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277003828 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 745277003829 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 745277003830 ligand binding site [chemical binding]; other site 745277003831 NAD binding site [chemical binding]; other site 745277003832 catalytic site [active] 745277003833 homodimer interface [polypeptide binding]; other site 745277003834 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 745277003835 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 745277003836 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 745277003837 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 745277003838 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 745277003839 dimerization interface 3.5A [polypeptide binding]; other site 745277003840 active site 745277003841 hypothetical protein; Provisional; Region: PRK10847 745277003842 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 745277003843 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 745277003844 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 745277003845 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 745277003846 cell division protein DedD; Provisional; Region: PRK11633 745277003847 Sporulation related domain; Region: SPOR; pfam05036 745277003848 colicin V production protein; Provisional; Region: PRK10845 745277003849 amidophosphoribosyltransferase; Provisional; Region: PRK09246 745277003850 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 745277003851 active site 745277003852 tetramer interface [polypeptide binding]; other site 745277003853 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 745277003854 active site 745277003855 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 745277003856 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 745277003857 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745277003858 substrate binding pocket [chemical binding]; other site 745277003859 membrane-bound complex binding site; other site 745277003860 hinge residues; other site 745277003861 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 745277003862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277003863 dimer interface [polypeptide binding]; other site 745277003864 conserved gate region; other site 745277003865 putative PBP binding loops; other site 745277003866 ABC-ATPase subunit interface; other site 745277003867 ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism]; Region: ArtM; COG4160 745277003868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277003869 dimer interface [polypeptide binding]; other site 745277003870 conserved gate region; other site 745277003871 putative PBP binding loops; other site 745277003872 ABC-ATPase subunit interface; other site 745277003873 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 745277003874 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 745277003875 Walker A/P-loop; other site 745277003876 ATP binding site [chemical binding]; other site 745277003877 Q-loop/lid; other site 745277003878 ABC transporter signature motif; other site 745277003879 Walker B; other site 745277003880 D-loop; other site 745277003881 H-loop/switch region; other site 745277003882 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 745277003883 peptidase T-like protein; Region: PepT-like; TIGR01883 745277003884 metal binding site [ion binding]; metal-binding site 745277003885 dimer interface [polypeptide binding]; other site 745277003886 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 745277003887 antimicrobial peptide ABC transporter periplasmic binding protein SapA; Provisional; Region: PRK15109 745277003888 peptide binding site [polypeptide binding]; other site 745277003889 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 745277003890 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 745277003891 putative NAD(P) binding site [chemical binding]; other site 745277003892 putative active site [active] 745277003893 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 745277003894 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 745277003895 C-terminal domain interface [polypeptide binding]; other site 745277003896 GSH binding site (G-site) [chemical binding]; other site 745277003897 dimer interface [polypeptide binding]; other site 745277003898 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 745277003899 N-terminal domain interface [polypeptide binding]; other site 745277003900 putative dimer interface [polypeptide binding]; other site 745277003901 active site 745277003902 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 745277003903 nudix motif; other site 745277003904 Transcriptional regulators [Transcription]; Region: PurR; COG1609 745277003905 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745277003906 DNA binding site [nucleotide binding] 745277003907 domain linker motif; other site 745277003908 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 745277003909 putative dimerization interface [polypeptide binding]; other site 745277003910 putative ligand binding site [chemical binding]; other site 745277003911 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 745277003912 active site 745277003913 phosphorylation site [posttranslational modification] 745277003914 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 745277003915 active site 745277003916 P-loop; other site 745277003917 phosphorylation site [posttranslational modification] 745277003918 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 745277003919 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 745277003920 TPP-binding site [chemical binding]; other site 745277003921 dimer interface [polypeptide binding]; other site 745277003922 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 745277003923 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 745277003924 PYR/PP interface [polypeptide binding]; other site 745277003925 dimer interface [polypeptide binding]; other site 745277003926 TPP binding site [chemical binding]; other site 745277003927 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 745277003928 phosphate acetyltransferase; Reviewed; Region: PRK05632 745277003929 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 745277003930 DRTGG domain; Region: DRTGG; pfam07085 745277003931 phosphate acetyltransferase; Region: pta; TIGR00651 745277003932 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 745277003933 hypothetical protein; Provisional; Region: PRK01816 745277003934 hypothetical protein; Validated; Region: PRK05445 745277003935 putative phosphatase; Provisional; Region: PRK11587 745277003936 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745277003937 active site 745277003938 motif I; other site 745277003939 motif II; other site 745277003940 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 745277003941 transmembrane helices; other site 745277003942 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 745277003943 TrkA-C domain; Region: TrkA_C; pfam02080 745277003944 TrkA-C domain; Region: TrkA_C; pfam02080 745277003945 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 745277003946 5'-nucleotidase; Provisional; Region: PRK03826 745277003947 aminotransferase AlaT; Validated; Region: PRK09265 745277003948 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 745277003949 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277003950 homodimer interface [polypeptide binding]; other site 745277003951 catalytic residue [active] 745277003952 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 745277003953 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277003954 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 745277003955 putative dimerization interface [polypeptide binding]; other site 745277003956 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 745277003957 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 745277003958 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 745277003959 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 745277003960 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 745277003961 NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905 745277003962 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 745277003963 putative dimer interface [polypeptide binding]; other site 745277003964 [2Fe-2S] cluster binding site [ion binding]; other site 745277003965 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 745277003966 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 745277003967 SLBB domain; Region: SLBB; pfam10531 745277003968 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 745277003969 NADH dehydrogenase subunit G; Validated; Region: PRK08166 745277003970 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 745277003971 catalytic loop [active] 745277003972 iron binding site [ion binding]; other site 745277003973 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 745277003974 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 745277003975 [4Fe-4S] binding site [ion binding]; other site 745277003976 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 745277003977 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 745277003978 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 745277003979 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 745277003980 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 745277003981 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 745277003982 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 745277003983 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 745277003984 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 745277003985 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 745277003986 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 745277003987 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 745277003988 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 745277003989 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 745277003990 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 745277003991 hypothetical protein; Provisional; Region: PRK10404 745277003992 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 745277003993 chorismate binding enzyme; Region: Chorismate_bind; cl10555 745277003994 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 745277003995 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 745277003996 dimer interface [polypeptide binding]; other site 745277003997 tetramer interface [polypeptide binding]; other site 745277003998 PYR/PP interface [polypeptide binding]; other site 745277003999 TPP binding site [chemical binding]; other site 745277004000 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 745277004001 TPP-binding site; other site 745277004002 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 745277004003 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 745277004004 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 745277004005 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 745277004006 substrate binding site [chemical binding]; other site 745277004007 oxyanion hole (OAH) forming residues; other site 745277004008 trimer interface [polypeptide binding]; other site 745277004009 O-succinylbenzoate synthase; Provisional; Region: PRK05105 745277004010 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 745277004011 active site 745277004012 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 745277004013 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 745277004014 acyl-activating enzyme (AAE) consensus motif; other site 745277004015 putative AMP binding site [chemical binding]; other site 745277004016 putative active site [active] 745277004017 putative CoA binding site [chemical binding]; other site 745277004018 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 745277004019 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 745277004020 tetramer interface [polypeptide binding]; other site 745277004021 heme binding pocket [chemical binding]; other site 745277004022 NADPH binding site [chemical binding]; other site 745277004023 YfaZ precursor; Region: YfaZ; pfam07437 745277004024 hypothetical protein; Provisional; Region: PRK03673 745277004025 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 745277004026 putative MPT binding site; other site 745277004027 Competence-damaged protein; Region: CinA; cl00666 745277004028 putative transposase OrfB; Reviewed; Region: PHA02517 745277004029 HTH-like domain; Region: HTH_21; pfam13276 745277004030 Integrase core domain; Region: rve; pfam00665 745277004031 Integrase core domain; Region: rve_2; pfam13333 745277004032 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 745277004033 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 745277004034 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 745277004035 catalytic loop [active] 745277004036 iron binding site [ion binding]; other site 745277004037 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 745277004038 dimer interface [polypeptide binding]; other site 745277004039 putative radical transfer pathway; other site 745277004040 diiron center [ion binding]; other site 745277004041 tyrosyl radical; other site 745277004042 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 745277004043 ATP cone domain; Region: ATP-cone; pfam03477 745277004044 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 745277004045 adhesin; Provisional; Region: PRK09752 745277004046 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 745277004047 Autotransporter beta-domain; Region: Autotransporter; smart00869 745277004048 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 745277004049 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277004050 S-adenosylmethionine binding site [chemical binding]; other site 745277004051 DNA gyrase subunit A; Validated; Region: PRK05560 745277004052 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 745277004053 CAP-like domain; other site 745277004054 active site 745277004055 primary dimer interface [polypeptide binding]; other site 745277004056 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 745277004057 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 745277004058 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 745277004059 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 745277004060 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 745277004061 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 745277004062 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 745277004063 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745277004064 dimer interface [polypeptide binding]; other site 745277004065 phosphorylation site [posttranslational modification] 745277004066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277004067 ATP binding site [chemical binding]; other site 745277004068 Mg2+ binding site [ion binding]; other site 745277004069 G-X-G motif; other site 745277004070 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 745277004071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277004072 active site 745277004073 phosphorylation site [posttranslational modification] 745277004074 intermolecular recognition site; other site 745277004075 dimerization interface [polypeptide binding]; other site 745277004076 transcriptional regulator RcsB; Provisional; Region: PRK10840 745277004077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277004078 active site 745277004079 phosphorylation site [posttranslational modification] 745277004080 intermolecular recognition site; other site 745277004081 dimerization interface [polypeptide binding]; other site 745277004082 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 745277004083 DNA binding residues [nucleotide binding] 745277004084 dimerization interface [polypeptide binding]; other site 745277004085 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 745277004086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277004087 ATP binding site [chemical binding]; other site 745277004088 Mg2+ binding site [ion binding]; other site 745277004089 G-X-G motif; other site 745277004090 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 745277004091 putative binding surface; other site 745277004092 active site 745277004093 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 745277004094 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 745277004095 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 745277004096 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 745277004097 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 745277004098 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 745277004099 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 745277004100 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 745277004101 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 745277004102 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 745277004103 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 745277004104 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 745277004105 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 745277004106 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 745277004107 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 745277004108 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 745277004109 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 745277004110 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 745277004111 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 745277004112 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 745277004113 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 745277004114 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 745277004115 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 745277004116 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 745277004117 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 745277004118 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 745277004119 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 745277004120 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 745277004121 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 745277004122 Outer membrane efflux protein; Region: OEP; pfam02321 745277004123 Outer membrane efflux protein; Region: OEP; pfam02321 745277004124 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 745277004125 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 745277004126 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745277004127 Walker A/P-loop; other site 745277004128 ATP binding site [chemical binding]; other site 745277004129 Q-loop/lid; other site 745277004130 ABC transporter signature motif; other site 745277004131 Walker B; other site 745277004132 D-loop; other site 745277004133 H-loop/switch region; other site 745277004134 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 745277004135 HlyD family secretion protein; Region: HlyD_3; pfam13437 745277004136 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 745277004137 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 745277004138 Sel1-like repeats; Region: SEL1; smart00671 745277004139 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 745277004140 trimer interface [polypeptide binding]; other site 745277004141 eyelet of channel; other site 745277004142 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 745277004143 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277004144 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 745277004145 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 745277004146 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 745277004147 DinI-like family; Region: DinI; pfam06183 745277004148 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 745277004149 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 745277004150 Sulfatase; Region: Sulfatase; cl19157 745277004151 hypothetical protein; Provisional; Region: PRK13689 745277004152 nucleoid-associated protein NdpA; Validated; Region: PRK00378 745277004153 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 745277004154 5S rRNA interface [nucleotide binding]; other site 745277004155 CTC domain interface [polypeptide binding]; other site 745277004156 L16 interface [polypeptide binding]; other site 745277004157 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 745277004158 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 745277004159 ATP binding site [chemical binding]; other site 745277004160 putative Mg++ binding site [ion binding]; other site 745277004161 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 745277004162 nucleotide binding region [chemical binding]; other site 745277004163 ATP-binding site [chemical binding]; other site 745277004164 Double zinc ribbon; Region: DZR; pfam12773 745277004165 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 745277004166 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 745277004167 RNA binding surface [nucleotide binding]; other site 745277004168 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 745277004169 active site 745277004170 uracil binding [chemical binding]; other site 745277004171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277004172 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 745277004173 putative substrate translocation pore; other site 745277004174 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 745277004175 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 745277004176 putative transposase OrfB; Reviewed; Region: PHA02517 745277004177 HTH-like domain; Region: HTH_21; pfam13276 745277004178 Integrase core domain; Region: rve; pfam00665 745277004179 Integrase core domain; Region: rve_2; pfam13333 745277004180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277004181 D-galactonate transporter; Region: 2A0114; TIGR00893 745277004182 putative substrate translocation pore; other site 745277004183 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 745277004184 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745277004185 DNA binding site [nucleotide binding] 745277004186 domain linker motif; other site 745277004187 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 745277004188 putative ligand binding site [chemical binding]; other site 745277004189 putative dimerization interface [polypeptide binding]; other site 745277004190 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 745277004191 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 745277004192 NADP binding site [chemical binding]; other site 745277004193 homodimer interface [polypeptide binding]; other site 745277004194 active site 745277004195 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 745277004196 classical (c) SDRs; Region: SDR_c; cd05233 745277004197 NAD(P) binding site [chemical binding]; other site 745277004198 active site 745277004199 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 745277004200 Cytochrome c; Region: Cytochrom_C; pfam00034 745277004201 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 745277004202 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 745277004203 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 745277004204 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 745277004205 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 745277004206 hypothetical protein; Provisional; Region: PRK11835 745277004207 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 745277004208 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277004209 Walker A/P-loop; other site 745277004210 ATP binding site [chemical binding]; other site 745277004211 Q-loop/lid; other site 745277004212 ABC transporter signature motif; other site 745277004213 Walker B; other site 745277004214 D-loop; other site 745277004215 H-loop/switch region; other site 745277004216 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745277004217 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277004218 Walker A/P-loop; other site 745277004219 ATP binding site [chemical binding]; other site 745277004220 Q-loop/lid; other site 745277004221 ABC transporter signature motif; other site 745277004222 Walker B; other site 745277004223 D-loop; other site 745277004224 H-loop/switch region; other site 745277004225 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745277004226 microcin C ABC transporter permease; Provisional; Region: PRK15021 745277004227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277004228 dimer interface [polypeptide binding]; other site 745277004229 conserved gate region; other site 745277004230 putative PBP binding loops; other site 745277004231 ABC-ATPase subunit interface; other site 745277004232 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 745277004233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277004234 dimer interface [polypeptide binding]; other site 745277004235 conserved gate region; other site 745277004236 putative PBP binding loops; other site 745277004237 ABC-ATPase subunit interface; other site 745277004238 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 745277004239 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 745277004240 phage resistance protein; Provisional; Region: PRK10551 745277004241 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 745277004242 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 745277004243 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 745277004244 NlpC/P60 family; Region: NLPC_P60; pfam00877 745277004245 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 745277004246 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 745277004247 active site 745277004248 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 745277004249 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 745277004250 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 745277004251 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 745277004252 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745277004253 DNA-binding site [nucleotide binding]; DNA binding site 745277004254 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 745277004255 D-mannonate oxidoreductase; Provisional; Region: PRK15037 745277004256 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 745277004257 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 745277004258 elongation factor P; Provisional; Region: PRK04542 745277004259 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 745277004260 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 745277004261 RNA binding site [nucleotide binding]; other site 745277004262 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 745277004263 RNA binding site [nucleotide binding]; other site 745277004264 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 745277004265 sugar efflux transporter B; Provisional; Region: PRK15011 745277004266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277004267 putative substrate translocation pore; other site 745277004268 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 745277004269 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 745277004270 active site 745277004271 phosphorylation site [posttranslational modification] 745277004272 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 745277004273 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 745277004274 dimerization domain swap beta strand [polypeptide binding]; other site 745277004275 regulatory protein interface [polypeptide binding]; other site 745277004276 active site 745277004277 regulatory phosphorylation site [posttranslational modification]; other site 745277004278 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 745277004279 putative substrate binding site [chemical binding]; other site 745277004280 putative ATP binding site [chemical binding]; other site 745277004281 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 745277004282 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 745277004283 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 745277004284 active site 745277004285 P-loop; other site 745277004286 phosphorylation site [posttranslational modification] 745277004287 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 745277004288 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 745277004289 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 745277004290 AP (apurinic/apyrimidinic) site pocket; other site 745277004291 DNA interaction; other site 745277004292 Metal-binding active site; metal-binding site 745277004293 Predicted membrane protein [Function unknown]; Region: COG2855 745277004294 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 745277004295 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277004296 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 745277004297 putative dimerization interface [polypeptide binding]; other site 745277004298 lysine transporter; Provisional; Region: PRK10836 745277004299 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 745277004300 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 745277004301 ABC-ATPase subunit interface; other site 745277004302 dimer interface [polypeptide binding]; other site 745277004303 putative PBP binding regions; other site 745277004304 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 745277004305 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 745277004306 Walker A/P-loop; other site 745277004307 ATP binding site [chemical binding]; other site 745277004308 Q-loop/lid; other site 745277004309 ABC transporter signature motif; other site 745277004310 Walker B; other site 745277004311 D-loop; other site 745277004312 H-loop/switch region; other site 745277004313 Predicted secreted acid phosphatase [General function prediction only]; Region: COG2503 745277004314 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 745277004315 trimer interface [polypeptide binding]; other site 745277004316 eyelet of channel; other site 745277004317 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 745277004318 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 745277004319 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 745277004320 glycosyl transferase family protein; Provisional; Region: PRK08136 745277004321 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 745277004322 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 745277004323 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 745277004324 PhnA protein; Region: PhnA; pfam03831 745277004325 Peptidase M3-like family, a zincin metallopeptidase, includes M3 and M32 families; Region: M3_like; cd06258 745277004326 active site 745277004327 Zn binding site [ion binding]; other site 745277004328 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 745277004329 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277004330 S-adenosylmethionine binding site [chemical binding]; other site 745277004331 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 745277004332 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 745277004333 Walker A/P-loop; other site 745277004334 ATP binding site [chemical binding]; other site 745277004335 Q-loop/lid; other site 745277004336 ABC transporter signature motif; other site 745277004337 Walker B; other site 745277004338 D-loop; other site 745277004339 H-loop/switch region; other site 745277004340 glutamine ABC transporter permease protein; Reviewed; Region: glnP; PRK09494 745277004341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277004342 dimer interface [polypeptide binding]; other site 745277004343 conserved gate region; other site 745277004344 putative PBP binding loops; other site 745277004345 ABC-ATPase subunit interface; other site 745277004346 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 745277004347 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745277004348 substrate binding pocket [chemical binding]; other site 745277004349 membrane-bound complex binding site; other site 745277004350 hinge residues; other site 745277004351 hypothetical protein; Provisional; Region: PRK11019 745277004352 Ferritin-like domain; Region: Ferritin; pfam00210 745277004353 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 745277004354 dimerization interface [polypeptide binding]; other site 745277004355 DPS ferroxidase diiron center [ion binding]; other site 745277004356 ion pore; other site 745277004357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 745277004358 Anti-sigma-K factor rskA; Region: RskA; pfam10099 745277004359 RNA polymerase sigma factor; Provisional; Region: PRK12534 745277004360 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 745277004361 Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649 745277004362 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 745277004363 DNA binding residues [nucleotide binding] 745277004364 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 745277004365 Fasciclin domain; Region: Fasciclin; pfam02469 745277004366 threonine and homoserine efflux system; Provisional; Region: PRK10532 745277004367 EamA-like transporter family; Region: EamA; pfam00892 745277004368 outer membrane protein X; Provisional; Region: ompX; PRK09408 745277004369 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 745277004370 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 745277004371 Moco binding site; other site 745277004372 metal coordination site [ion binding]; other site 745277004373 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 745277004374 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 745277004375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277004376 active site 745277004377 phosphorylation site [posttranslational modification] 745277004378 intermolecular recognition site; other site 745277004379 dimerization interface [polypeptide binding]; other site 745277004380 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 745277004381 DNA binding site [nucleotide binding] 745277004382 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 745277004383 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 745277004384 dimerization interface [polypeptide binding]; other site 745277004385 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745277004386 dimer interface [polypeptide binding]; other site 745277004387 phosphorylation site [posttranslational modification] 745277004388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277004389 ATP binding site [chemical binding]; other site 745277004390 Mg2+ binding site [ion binding]; other site 745277004391 G-X-G motif; other site 745277004392 phosphoethanolamine transferase; Provisional; Region: PRK11560 745277004393 Sulfatase; Region: Sulfatase; pfam00884 745277004394 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 745277004395 putative catalytic site [active] 745277004396 putative metal binding site [ion binding]; other site 745277004397 putative phosphate binding site [ion binding]; other site 745277004398 choline transport protein BetT; Provisional; Region: PRK09928 745277004399 transcriptional regulator BetI; Validated; Region: PRK00767 745277004400 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745277004401 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 745277004402 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 745277004403 tetrameric interface [polypeptide binding]; other site 745277004404 NAD binding site [chemical binding]; other site 745277004405 catalytic residues [active] 745277004406 choline dehydrogenase; Validated; Region: PRK02106 745277004407 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 745277004408 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 745277004409 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745277004410 Coenzyme A binding pocket [chemical binding]; other site 745277004411 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277004412 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277004413 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 745277004414 putative effector binding pocket; other site 745277004415 dimerization interface [polypeptide binding]; other site 745277004416 Protein of unknown function, DUF606; Region: DUF606; pfam04657 745277004417 Protein of unknown function, DUF606; Region: DUF606; pfam04657 745277004418 RES domain; Region: RES; cl02411 745277004419 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 745277004420 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 745277004421 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 745277004422 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 745277004423 ABC transporter; Region: ABC_tran_2; pfam12848 745277004424 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 745277004425 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 745277004426 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 745277004427 ATP binding site [chemical binding]; other site 745277004428 substrate interface [chemical binding]; other site 745277004429 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 745277004430 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 745277004431 dimer interface [polypeptide binding]; other site 745277004432 putative functional site; other site 745277004433 putative MPT binding site; other site 745277004434 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 745277004435 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 745277004436 putative transporter; Provisional; Region: PRK03699 745277004437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277004438 putative substrate translocation pore; other site 745277004439 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 745277004440 catalytic nucleophile [active] 745277004441 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 745277004442 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277004443 Walker A/P-loop; other site 745277004444 ATP binding site [chemical binding]; other site 745277004445 Q-loop/lid; other site 745277004446 ABC transporter signature motif; other site 745277004447 Walker B; other site 745277004448 D-loop; other site 745277004449 H-loop/switch region; other site 745277004450 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745277004451 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277004452 Walker A/P-loop; other site 745277004453 ATP binding site [chemical binding]; other site 745277004454 Q-loop/lid; other site 745277004455 ABC transporter signature motif; other site 745277004456 Walker B; other site 745277004457 D-loop; other site 745277004458 H-loop/switch region; other site 745277004459 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745277004460 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 745277004461 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 745277004462 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 745277004463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277004464 dimer interface [polypeptide binding]; other site 745277004465 conserved gate region; other site 745277004466 putative PBP binding loops; other site 745277004467 ABC-ATPase subunit interface; other site 745277004468 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 745277004469 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 745277004470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277004471 dimer interface [polypeptide binding]; other site 745277004472 conserved gate region; other site 745277004473 putative PBP binding loops; other site 745277004474 ABC-ATPase subunit interface; other site 745277004475 S-formylglutathione hydrolase; Region: PLN02442 745277004476 Predicted esterase [General function prediction only]; Region: COG0627 745277004477 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 745277004478 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 745277004479 substrate binding site [chemical binding]; other site 745277004480 catalytic Zn binding site [ion binding]; other site 745277004481 NAD binding site [chemical binding]; other site 745277004482 structural Zn binding site [ion binding]; other site 745277004483 dimer interface [polypeptide binding]; other site 745277004484 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277004485 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277004486 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 745277004487 putative dimerization interface [polypeptide binding]; other site 745277004488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277004489 Major Facilitator Superfamily; Region: MFS_1; pfam07690 745277004490 putative substrate translocation pore; other site 745277004491 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 745277004492 active site 745277004493 Predicted membrane protein [Function unknown]; Region: COG2311 745277004494 hypothetical protein; Provisional; Region: PRK10835 745277004495 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 745277004496 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745277004497 DNA binding site [nucleotide binding] 745277004498 domain linker motif; other site 745277004499 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 745277004500 dimerization interface (closed form) [polypeptide binding]; other site 745277004501 ligand binding site [chemical binding]; other site 745277004502 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 745277004503 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 745277004504 ligand binding site [chemical binding]; other site 745277004505 calcium binding site [ion binding]; other site 745277004506 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 745277004507 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 745277004508 Walker A/P-loop; other site 745277004509 ATP binding site [chemical binding]; other site 745277004510 Q-loop/lid; other site 745277004511 ABC transporter signature motif; other site 745277004512 Walker B; other site 745277004513 D-loop; other site 745277004514 H-loop/switch region; other site 745277004515 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 745277004516 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 745277004517 TM-ABC transporter signature motif; other site 745277004518 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 745277004519 putative active site [active] 745277004520 malate dehydrogenase; Provisional; Region: PRK13529 745277004521 Malic enzyme, N-terminal domain; Region: malic; pfam00390 745277004522 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 745277004523 NAD(P) binding site [chemical binding]; other site 745277004524 cytidine deaminase; Provisional; Region: PRK09027 745277004525 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 745277004526 active site 745277004527 catalytic motif [active] 745277004528 Zn binding site [ion binding]; other site 745277004529 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 745277004530 active site 745277004531 catalytic motif [active] 745277004532 Zn binding site [ion binding]; other site 745277004533 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 745277004534 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745277004535 substrate binding pocket [chemical binding]; other site 745277004536 membrane-bound complex binding site; other site 745277004537 hinge residues; other site 745277004538 arginine transporter permease subunit ArtM; Provisional; Region: artM; PRK11122 745277004539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277004540 dimer interface [polypeptide binding]; other site 745277004541 conserved gate region; other site 745277004542 putative PBP binding loops; other site 745277004543 ABC-ATPase subunit interface; other site 745277004544 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 745277004545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277004546 dimer interface [polypeptide binding]; other site 745277004547 conserved gate region; other site 745277004548 putative PBP binding loops; other site 745277004549 ABC-ATPase subunit interface; other site 745277004550 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 745277004551 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745277004552 substrate binding pocket [chemical binding]; other site 745277004553 membrane-bound complex binding site; other site 745277004554 hinge residues; other site 745277004555 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 745277004556 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745277004557 Walker A/P-loop; other site 745277004558 ATP binding site [chemical binding]; other site 745277004559 Q-loop/lid; other site 745277004560 ABC transporter signature motif; other site 745277004561 Walker B; other site 745277004562 D-loop; other site 745277004563 H-loop/switch region; other site 745277004564 putative lipoprotein; Provisional; Region: PRK10533 745277004565 hypothetical protein; Provisional; Region: PRK02877 745277004566 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 745277004567 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 745277004568 amidase catalytic site [active] 745277004569 Zn binding residues [ion binding]; other site 745277004570 substrate binding site [chemical binding]; other site 745277004571 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 745277004572 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745277004573 NAD(P) binding site [chemical binding]; other site 745277004574 active site 745277004575 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 745277004576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745277004577 NAD(P) binding site [chemical binding]; other site 745277004578 active site 745277004579 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 745277004580 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 745277004581 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 745277004582 tetramer interface [polypeptide binding]; other site 745277004583 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277004584 catalytic residue [active] 745277004585 pyruvate dehydrogenase; Provisional; Region: PRK09124 745277004586 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 745277004587 PYR/PP interface [polypeptide binding]; other site 745277004588 dimer interface [polypeptide binding]; other site 745277004589 tetramer interface [polypeptide binding]; other site 745277004590 TPP binding site [chemical binding]; other site 745277004591 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 745277004592 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 745277004593 TPP-binding site [chemical binding]; other site 745277004594 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 745277004595 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 745277004596 FAD binding pocket [chemical binding]; other site 745277004597 FAD binding motif [chemical binding]; other site 745277004598 phosphate binding motif [ion binding]; other site 745277004599 beta-alpha-beta structure motif; other site 745277004600 NAD binding pocket [chemical binding]; other site 745277004601 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 745277004602 catalytic loop [active] 745277004603 iron binding site [ion binding]; other site 745277004604 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 745277004605 cubane metal cluster [ion binding]; other site 745277004606 hybrid metal cluster; other site 745277004607 Predicted membrane protein [Function unknown]; Region: COG2431 745277004608 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 745277004609 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 745277004610 putative active site [active] 745277004611 putative metal-binding site [ion binding]; other site 745277004612 Protein of unknown function (DUF535); Region: DUF535; pfam04393 745277004613 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 745277004614 DNA-binding site [nucleotide binding]; DNA binding site 745277004615 RNA-binding motif; other site 745277004616 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 745277004617 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 745277004618 Clp amino terminal domain; Region: Clp_N; pfam02861 745277004619 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745277004620 Walker A motif; other site 745277004621 ATP binding site [chemical binding]; other site 745277004622 Walker B motif; other site 745277004623 arginine finger; other site 745277004624 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745277004625 Walker A motif; other site 745277004626 ATP binding site [chemical binding]; other site 745277004627 Walker B motif; other site 745277004628 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 745277004629 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 745277004630 rRNA binding site [nucleotide binding]; other site 745277004631 predicted 30S ribosome binding site; other site 745277004632 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 745277004633 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 745277004634 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 745277004635 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 745277004636 Walker A/P-loop; other site 745277004637 ATP binding site [chemical binding]; other site 745277004638 Q-loop/lid; other site 745277004639 ABC transporter signature motif; other site 745277004640 Walker B; other site 745277004641 D-loop; other site 745277004642 H-loop/switch region; other site 745277004643 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 745277004644 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 745277004645 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745277004646 Walker A/P-loop; other site 745277004647 ATP binding site [chemical binding]; other site 745277004648 Q-loop/lid; other site 745277004649 ABC transporter signature motif; other site 745277004650 Walker B; other site 745277004651 D-loop; other site 745277004652 H-loop/switch region; other site 745277004653 thioredoxin reductase; Provisional; Region: PRK10262 745277004654 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 745277004655 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 745277004656 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 745277004657 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 745277004658 putative DNA binding site [nucleotide binding]; other site 745277004659 putative Zn2+ binding site [ion binding]; other site 745277004660 AsnC family; Region: AsnC_trans_reg; pfam01037 745277004661 DNA translocase FtsK; Provisional; Region: PRK10263 745277004662 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 745277004663 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 745277004664 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 745277004665 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 745277004666 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl19192 745277004667 recombination factor protein RarA; Reviewed; Region: PRK13342 745277004668 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745277004669 Walker A motif; other site 745277004670 ATP binding site [chemical binding]; other site 745277004671 Walker B motif; other site 745277004672 arginine finger; other site 745277004673 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 745277004674 seryl-tRNA synthetase; Provisional; Region: PRK05431 745277004675 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 745277004676 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 745277004677 dimer interface [polypeptide binding]; other site 745277004678 active site 745277004679 motif 1; other site 745277004680 motif 2; other site 745277004681 motif 3; other site 745277004682 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 745277004683 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 745277004684 putative [Fe4-S4] binding site [ion binding]; other site 745277004685 putative molybdopterin cofactor binding site [chemical binding]; other site 745277004686 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 745277004687 putative molybdopterin cofactor binding site; other site 745277004688 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 745277004689 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 745277004690 putative [Fe4-S4] binding site [ion binding]; other site 745277004691 putative molybdopterin cofactor binding site [chemical binding]; other site 745277004692 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 745277004693 putative molybdopterin cofactor binding site; other site 745277004694 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 745277004695 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 745277004696 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 745277004697 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 745277004698 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 745277004699 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 745277004700 putative MFS family transporter protein; Provisional; Region: PRK03633 745277004701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277004702 putative substrate translocation pore; other site 745277004703 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 745277004704 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 745277004705 FeS/SAM binding site; other site 745277004706 integrase; Provisional; Region: int; PHA02601 745277004707 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 745277004708 active site 745277004709 DNA binding site [nucleotide binding] 745277004710 Int/Topo IB signature motif; other site 745277004711 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745277004712 non-specific DNA binding site [nucleotide binding]; other site 745277004713 salt bridge; other site 745277004714 sequence-specific DNA binding site [nucleotide binding]; other site 745277004715 Regulatory phage protein cox; Region: Phage_Cox; pfam10743 745277004716 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 745277004717 DksA-like zinc finger domain containing protein; Region: PHA00080 745277004718 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 745277004719 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 745277004720 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 745277004721 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745277004722 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 745277004723 active site 745277004724 motif I; other site 745277004725 motif II; other site 745277004726 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 745277004727 active site 745277004728 Protein of unknown function (DUF674); Region: DUF674; pfam05056 745277004729 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 745277004730 portal vertex protein; Provisional; Region: Q; PHA02536 745277004731 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 745277004732 capsid protein; Provisional; Region: N; PHA02538 745277004733 Phage small terminase subunit; Region: Phage_term_smal; cl19614 745277004734 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 745277004735 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 745277004736 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 745277004737 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 745277004738 catalytic residues [active] 745277004739 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 745277004740 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 745277004741 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 745277004742 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 745277004743 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 745277004744 baseplate assembly protein; Provisional; Region: J; PHA02568 745277004745 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 745277004746 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 745277004747 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 745277004748 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 745277004749 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 745277004750 major tail sheath protein; Provisional; Region: FI; PHA02560 745277004751 major tail tube protein; Provisional; Region: FII; PHA02600 745277004752 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 745277004753 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 745277004754 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 745277004755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277004756 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 745277004757 tail protein; Provisional; Region: D; PHA02561 745277004758 Ogr/Delta-like zinc finger; Region: Ogr_Delta; cl19592 745277004759 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 745277004760 Pyruvate formate lyase 1; Region: PFL1; cd01678 745277004761 coenzyme A binding site [chemical binding]; other site 745277004762 active site 745277004763 catalytic residues [active] 745277004764 glycine loop; other site 745277004765 formate transporter; Provisional; Region: PRK10805 745277004766 YcaO-like family; Region: YcaO; cl19253 745277004767 Predicted membrane protein [Function unknown]; Region: COG2323 745277004768 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 745277004769 homodimer interface [polypeptide binding]; other site 745277004770 substrate-cofactor binding pocket; other site 745277004771 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277004772 catalytic residue [active] 745277004773 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 745277004774 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 745277004775 hinge; other site 745277004776 active site 745277004777 cytidylate kinase; Provisional; Region: cmk; PRK00023 745277004778 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 745277004779 CMP-binding site; other site 745277004780 The sites determining sugar specificity; other site 745277004781 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 745277004782 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 745277004783 RNA binding site [nucleotide binding]; other site 745277004784 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 745277004785 RNA binding site [nucleotide binding]; other site 745277004786 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 745277004787 RNA binding site [nucleotide binding]; other site 745277004788 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 745277004789 RNA binding site [nucleotide binding]; other site 745277004790 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 745277004791 RNA binding site [nucleotide binding]; other site 745277004792 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 745277004793 RNA binding site [nucleotide binding]; other site 745277004794 Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836 745277004795 dimer interface [polypeptide binding]; other site 745277004796 DNA binding site [nucleotide binding] 745277004797 ComEC family competence protein; Provisional; Region: PRK11539 745277004798 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 745277004799 Competence protein; Region: Competence; pfam03772 745277004800 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 745277004801 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 745277004802 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 745277004803 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 745277004804 Walker A/P-loop; other site 745277004805 ATP binding site [chemical binding]; other site 745277004806 Q-loop/lid; other site 745277004807 ABC transporter signature motif; other site 745277004808 Walker B; other site 745277004809 D-loop; other site 745277004810 H-loop/switch region; other site 745277004811 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 745277004812 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 745277004813 DNA-binding site [nucleotide binding]; DNA binding site 745277004814 RNA-binding motif; other site 745277004815 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 745277004816 DNA-binding site [nucleotide binding]; DNA binding site 745277004817 RNA-binding motif; other site 745277004818 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 745277004819 Trm112p-like protein; Region: Trm112p; cl01066 745277004820 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 745277004821 Ligand binding site; other site 745277004822 oligomer interface; other site 745277004823 hypothetical protein; Provisional; Region: PRK10593 745277004824 Phosphotransferase enzyme family; Region: APH; pfam01636 745277004825 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 745277004826 putative active site [active] 745277004827 Methyltransferase domain; Region: Methyltransf_31; pfam13847 745277004828 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277004829 S-adenosylmethionine binding site [chemical binding]; other site 745277004830 condesin subunit F; Provisional; Region: PRK05260 745277004831 condesin subunit E; Provisional; Region: PRK05256 745277004832 cell division protein MukB; Provisional; Region: mukB; PRK04863 745277004833 P-loop containing region of AAA domain; Region: AAA_29; cl17516 745277004834 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 745277004835 murein L,D-transpeptidase; Provisional; Region: PRK10594 745277004836 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 745277004837 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 745277004838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 745277004839 Peptidase M15; Region: Peptidase_M15_3; cl01194 745277004840 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 745277004841 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 745277004842 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 745277004843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277004844 homodimer interface [polypeptide binding]; other site 745277004845 catalytic residue [active] 745277004846 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 745277004847 trimer interface [polypeptide binding]; other site 745277004848 eyelet of channel; other site 745277004849 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 745277004850 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 745277004851 putative dimer interface [polypeptide binding]; other site 745277004852 putative anticodon binding site; other site 745277004853 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 745277004854 homodimer interface [polypeptide binding]; other site 745277004855 motif 1; other site 745277004856 motif 2; other site 745277004857 active site 745277004858 motif 3; other site 745277004859 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 745277004860 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 745277004861 active site 745277004862 aminopeptidase N; Provisional; Region: pepN; PRK14015 745277004863 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 745277004864 active site 745277004865 Zn binding site [ion binding]; other site 745277004866 Transposase IS200 like; Region: Y1_Tnp; pfam01797 745277004867 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 745277004868 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 745277004869 Walker A/P-loop; other site 745277004870 ATP binding site [chemical binding]; other site 745277004871 Q-loop/lid; other site 745277004872 ABC transporter signature motif; other site 745277004873 Walker B; other site 745277004874 D-loop; other site 745277004875 H-loop/switch region; other site 745277004876 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 745277004877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277004878 dimer interface [polypeptide binding]; other site 745277004879 conserved gate region; other site 745277004880 putative PBP binding loops; other site 745277004881 ABC-ATPase subunit interface; other site 745277004882 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 745277004883 active site 745277004884 dimer interface [polypeptide binding]; other site 745277004885 non-prolyl cis peptide bond; other site 745277004886 insertion regions; other site 745277004887 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 745277004888 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745277004889 substrate binding pocket [chemical binding]; other site 745277004890 membrane-bound complex binding site; other site 745277004891 hinge residues; other site 745277004892 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 745277004893 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 745277004894 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 745277004895 quinone interaction residues [chemical binding]; other site 745277004896 active site 745277004897 catalytic residues [active] 745277004898 FMN binding site [chemical binding]; other site 745277004899 substrate binding site [chemical binding]; other site 745277004900 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 745277004901 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 745277004902 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 745277004903 MOSC domain; Region: MOSC; pfam03473 745277004904 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 745277004905 catalytic loop [active] 745277004906 iron binding site [ion binding]; other site 745277004907 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 745277004908 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 745277004909 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 745277004910 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277004911 S-adenosylmethionine binding site [chemical binding]; other site 745277004912 ABC transporter ATPase component; Reviewed; Region: PRK11147 745277004913 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 745277004914 ABC transporter; Region: ABC_tran_2; pfam12848 745277004915 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 745277004916 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 745277004917 Paraquat-inducible protein A; Region: PqiA; pfam04403 745277004918 Paraquat-inducible protein A; Region: PqiA; pfam04403 745277004919 paraquat-inducible protein B; Provisional; Region: PRK10807 745277004920 mce related protein; Region: MCE; pfam02470 745277004921 mce related protein; Region: MCE; pfam02470 745277004922 mce related protein; Region: MCE; pfam02470 745277004923 Protein of unknown function (DUF330); Region: DUF330; cl01135 745277004924 ribosome modulation factor; Provisional; Region: PRK14563 745277004925 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 745277004926 active site 1 [active] 745277004927 dimer interface [polypeptide binding]; other site 745277004928 active site 2 [active] 745277004929 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 745277004930 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 745277004931 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 745277004932 outer membrane protein A; Reviewed; Region: PRK10808 745277004933 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 745277004934 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 745277004935 ligand binding site [chemical binding]; other site 745277004936 SOS cell division inhibitor; Provisional; Region: PRK10595 745277004937 TfoX N-terminal domain; Region: TfoX_N; pfam04993 745277004938 TfoX C-terminal domain; Region: TfoX_C; pfam04994 745277004939 TIGR01666 family membrane protein; Region: YCCS 745277004940 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 745277004941 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 745277004942 Predicted membrane protein [Function unknown]; Region: COG3304 745277004943 Domain of unknown function (DUF307); Region: DUF307; pfam03733 745277004944 Domain of unknown function (DUF307); Region: DUF307; pfam03733 745277004945 DNA helicase IV; Provisional; Region: helD; PRK11054 745277004946 DNA helicase IV / RNA helicase N terminal; Region: Helicase_IV_N; pfam12462 745277004947 Part of AAA domain; Region: AAA_19; pfam13245 745277004948 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 745277004949 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 745277004950 active site 745277004951 dimer interfaces [polypeptide binding]; other site 745277004952 catalytic residues [active] 745277004953 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 745277004954 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 745277004955 heat shock protein HspQ; Provisional; Region: PRK14129 745277004956 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 745277004957 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 745277004958 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 745277004959 putative RNA binding site [nucleotide binding]; other site 745277004960 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277004961 S-adenosylmethionine binding site [chemical binding]; other site 745277004962 acylphosphatase; Provisional; Region: PRK14426 745277004963 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 745277004964 YccA-like proteins; Region: YccA_like; cd10433 745277004965 Cupin; Region: Cupin_6; pfam12852 745277004966 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277004967 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 745277004968 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277004969 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 745277004970 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 745277004971 putative NAD(P) binding site [chemical binding]; other site 745277004972 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 745277004973 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 745277004974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277004975 dimer interface [polypeptide binding]; other site 745277004976 conserved gate region; other site 745277004977 putative PBP binding loops; other site 745277004978 ABC-ATPase subunit interface; other site 745277004979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277004980 dimer interface [polypeptide binding]; other site 745277004981 conserved gate region; other site 745277004982 putative PBP binding loops; other site 745277004983 ABC-ATPase subunit interface; other site 745277004984 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 745277004985 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745277004986 Walker A/P-loop; other site 745277004987 ATP binding site [chemical binding]; other site 745277004988 Q-loop/lid; other site 745277004989 ABC transporter signature motif; other site 745277004990 Walker B; other site 745277004991 D-loop; other site 745277004992 H-loop/switch region; other site 745277004993 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 745277004994 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 745277004995 dimer interface [polypeptide binding]; other site 745277004996 ligand binding site [chemical binding]; other site 745277004997 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 745277004998 dimerization interface [polypeptide binding]; other site 745277004999 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 745277005000 dimer interface [polypeptide binding]; other site 745277005001 putative CheW interface [polypeptide binding]; other site 745277005002 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 745277005003 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 745277005004 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 745277005005 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 745277005006 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745277005007 DNA-binding site [nucleotide binding]; DNA binding site 745277005008 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 745277005009 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 745277005010 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 745277005011 active site turn [active] 745277005012 phosphorylation site [posttranslational modification] 745277005013 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 745277005014 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 745277005015 potassium/proton antiporter; Reviewed; Region: PRK05326 745277005016 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 745277005017 TrkA-C domain; Region: TrkA_C; pfam02080 745277005018 Transporter associated domain; Region: CorC_HlyC; smart01091 745277005019 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 745277005020 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 745277005021 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 745277005022 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745277005023 non-specific DNA binding site [nucleotide binding]; other site 745277005024 salt bridge; other site 745277005025 sequence-specific DNA binding site [nucleotide binding]; other site 745277005026 Cupin domain; Region: Cupin_2; pfam07883 745277005027 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 745277005028 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 745277005029 catalytic triad [active] 745277005030 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 745277005031 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 745277005032 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 745277005033 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 745277005034 exonuclease I; Provisional; Region: sbcB; PRK11779 745277005035 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 745277005036 active site 745277005037 catalytic site [active] 745277005038 substrate binding site [chemical binding]; other site 745277005039 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 745277005040 Predicted membrane protein [Function unknown]; Region: COG1289 745277005041 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 745277005042 hypothetical protein; Provisional; Region: PRK05423 745277005043 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 745277005044 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 745277005045 dimerization interface [polypeptide binding]; other site 745277005046 NAD binding site [chemical binding]; other site 745277005047 ligand binding site [chemical binding]; other site 745277005048 catalytic site [active] 745277005049 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 745277005050 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 745277005051 Walker A/P-loop; other site 745277005052 ATP binding site [chemical binding]; other site 745277005053 Q-loop/lid; other site 745277005054 ABC transporter signature motif; other site 745277005055 Walker B; other site 745277005056 D-loop; other site 745277005057 H-loop/switch region; other site 745277005058 TOBE domain; Region: TOBE; pfam03459 745277005059 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 745277005060 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 745277005061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277005062 dimer interface [polypeptide binding]; other site 745277005063 conserved gate region; other site 745277005064 putative PBP binding loops; other site 745277005065 ABC-ATPase subunit interface; other site 745277005066 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 745277005067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277005068 dimer interface [polypeptide binding]; other site 745277005069 conserved gate region; other site 745277005070 putative PBP binding loops; other site 745277005071 ABC-ATPase subunit interface; other site 745277005072 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 745277005073 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 745277005074 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 745277005075 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 745277005076 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 745277005077 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 745277005078 active site turn [active] 745277005079 phosphorylation site [posttranslational modification] 745277005080 maltoporin; Provisional; Region: lamB; PRK09360 745277005081 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 745277005082 trimer interface; other site 745277005083 sugar binding site [chemical binding]; other site 745277005084 lac repressor; Reviewed; Region: lacI; PRK09526 745277005085 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745277005086 DNA binding site [nucleotide binding] 745277005087 domain linker motif; other site 745277005088 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 745277005089 ligand binding site [chemical binding]; other site 745277005090 dimerization interface (open form) [polypeptide binding]; other site 745277005091 dimerization interface (closed form) [polypeptide binding]; other site 745277005092 Serine hydrolase; Region: Ser_hydrolase; pfam06821 745277005093 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 745277005094 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 745277005095 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 745277005096 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 745277005097 citrate lyase subunit gamma; Provisional; Region: PRK13253 745277005098 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 745277005099 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 745277005100 putative active site [active] 745277005101 (T/H)XGH motif; other site 745277005102 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 745277005103 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 745277005104 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 745277005105 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 745277005106 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 745277005107 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 745277005108 putative active site [active] 745277005109 heme pocket [chemical binding]; other site 745277005110 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 745277005111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277005112 ATP binding site [chemical binding]; other site 745277005113 Mg2+ binding site [ion binding]; other site 745277005114 G-X-G motif; other site 745277005115 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 745277005116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277005117 active site 745277005118 phosphorylation site [posttranslational modification] 745277005119 intermolecular recognition site; other site 745277005120 dimerization interface [polypeptide binding]; other site 745277005121 Transcriptional regulator; Region: CitT; pfam12431 745277005122 MATE family multidrug exporter; Provisional; Region: PRK10189 745277005123 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 745277005124 AMP nucleosidase; Provisional; Region: PRK08292 745277005125 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 745277005126 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 745277005127 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 745277005128 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 745277005129 putative C-terminal domain interface [polypeptide binding]; other site 745277005130 putative GSH binding site (G-site) [chemical binding]; other site 745277005131 putative dimer interface [polypeptide binding]; other site 745277005132 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 745277005133 N-terminal domain interface [polypeptide binding]; other site 745277005134 dimer interface [polypeptide binding]; other site 745277005135 substrate binding pocket (H-site) [chemical binding]; other site 745277005136 shikimate transporter; Provisional; Region: PRK09952 745277005137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277005138 putative substrate translocation pore; other site 745277005139 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 745277005140 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 745277005141 active site 745277005142 Predicted membrane protein [Function unknown]; Region: COG1288 745277005143 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 745277005144 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 745277005145 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 745277005146 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 745277005147 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 745277005148 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 745277005149 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 745277005150 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 745277005151 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 745277005152 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 745277005153 substrate binding site [chemical binding]; other site 745277005154 ATP binding site [chemical binding]; other site 745277005155 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 745277005156 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 745277005157 putative active site [active] 745277005158 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 745277005159 dimer interface [polypeptide binding]; other site 745277005160 active site 745277005161 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 745277005162 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745277005163 substrate binding pocket [chemical binding]; other site 745277005164 membrane-bound complex binding site; other site 745277005165 hinge residues; other site 745277005166 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 745277005167 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 745277005168 DNA-binding site [nucleotide binding]; DNA binding site 745277005169 UTRA domain; Region: UTRA; pfam07702 745277005170 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 745277005171 Outer membrane efflux protein; Region: OEP; pfam02321 745277005172 Outer membrane efflux protein; Region: OEP; pfam02321 745277005173 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 745277005174 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745277005175 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 745277005176 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 745277005177 HlyD family secretion protein; Region: HlyD_3; pfam13437 745277005178 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 745277005179 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 745277005180 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745277005181 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 745277005182 FMN binding site [chemical binding]; other site 745277005183 active site 745277005184 substrate binding site [chemical binding]; other site 745277005185 catalytic residue [active] 745277005186 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 745277005187 classical (c) SDRs; Region: SDR_c; cd05233 745277005188 NAD(P) binding site [chemical binding]; other site 745277005189 active site 745277005190 short chain dehydrogenase; Provisional; Region: PRK06179 745277005191 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 745277005192 NADP binding site [chemical binding]; other site 745277005193 active site 745277005194 steroid binding site; other site 745277005195 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 745277005196 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 745277005197 putative NAD(P) binding site [chemical binding]; other site 745277005198 DNA repair protein RecN; Region: recN; TIGR00634 745277005199 AAA domain; Region: AAA_23; pfam13476 745277005200 Walker A/P-loop; other site 745277005201 ATP binding site [chemical binding]; other site 745277005202 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 745277005203 Protein of unknown function (DUF429); Region: DUF429; cl12046 745277005204 Restriction endonuclease; Region: Mrr_cat; cl19295 745277005205 Restriction endonuclease; Region: Mrr_cat; pfam04471 745277005206 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 745277005207 Protein of unknown function, DUF462; Region: DUF462; cl01190 745277005208 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 745277005209 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 745277005210 putative active site [active] 745277005211 putative NTP binding site [chemical binding]; other site 745277005212 putative nucleic acid binding site [nucleotide binding]; other site 745277005213 Protein kinase domain; Region: Pkinase; pfam00069 745277005214 Catalytic domain of Protein Kinases; Region: PKc; cd00180 745277005215 active site 745277005216 ATP binding site [chemical binding]; other site 745277005217 substrate binding site [chemical binding]; other site 745277005218 activation loop (A-loop); other site 745277005219 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 745277005220 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 745277005221 Domain of unknown function DUF87; Region: DUF87; cl19135 745277005222 AAA-like domain; Region: AAA_10; pfam12846 745277005223 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 745277005224 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 745277005225 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 745277005226 Nucleotidyltransferase domain; Region: NTP_transf_2; pfam01909 745277005227 metal binding triad [ion binding]; metal-binding site 745277005228 conjugal transfer protein TrbM; Provisional; Region: PRK13893 745277005229 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 745277005230 Walker A motif; other site 745277005231 ATP binding site [chemical binding]; other site 745277005232 Walker B motif; other site 745277005233 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 745277005234 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 745277005235 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 745277005236 VirB7 interaction site; other site 745277005237 VirB8 protein; Region: VirB8; pfam04335 745277005238 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 745277005239 Type IV secretion system proteins; Region: T4SS; pfam07996 745277005240 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 745277005241 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 745277005242 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 745277005243 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 745277005244 TrbC/VIRB2 family; Region: TrbC; pfam04956 745277005245 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 745277005246 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 745277005247 N-acetyl-D-glucosamine binding site [chemical binding]; other site 745277005248 catalytic residue [active] 745277005249 phage/conjugal plasmid C-4 type zinc finger protein, TraR family; Region: C4_traR_proteo; TIGR02419 745277005250 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 745277005251 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 745277005252 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 745277005253 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745277005254 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 745277005255 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 745277005256 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745277005257 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 745277005258 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 745277005259 HlyD family secretion protein; Region: HlyD_3; pfam13437 745277005260 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 745277005261 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 745277005262 HlyD family secretion protein; Region: HlyD_3; pfam13437 745277005263 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 745277005264 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 745277005265 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 745277005266 Outer membrane efflux protein; Region: OEP; pfam02321 745277005267 Outer membrane efflux protein; Region: OEP; pfam02321 745277005268 Transcriptional regulators [Transcription]; Region: MarR; COG1846 745277005269 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 745277005270 putative DNA binding site [nucleotide binding]; other site 745277005271 putative Zn2+ binding site [ion binding]; other site 745277005272 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 745277005273 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 745277005274 NAD(P) binding site [chemical binding]; other site 745277005275 integrase; Provisional; Region: PRK09692 745277005276 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 745277005277 active site 745277005278 Int/Topo IB signature motif; other site 745277005279 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 745277005280 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277005281 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 745277005282 putative dimerization interface [polypeptide binding]; other site 745277005283 Protein of unknown function (DUF466); Region: DUF466; cl01082 745277005284 carbon starvation protein A; Provisional; Region: PRK15015 745277005285 Carbon starvation protein CstA; Region: CstA; pfam02554 745277005286 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 745277005287 acid shock protein precursor; Provisional; Region: PRK03577 745277005288 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 745277005289 dimer interface [polypeptide binding]; other site 745277005290 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 745277005291 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745277005292 DNA-binding site [nucleotide binding]; DNA binding site 745277005293 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 745277005294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277005295 homodimer interface [polypeptide binding]; other site 745277005296 catalytic residue [active] 745277005297 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 745277005298 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 745277005299 N- and C-terminal domain interface [polypeptide binding]; other site 745277005300 active site 745277005301 MgATP binding site [chemical binding]; other site 745277005302 catalytic site [active] 745277005303 metal binding site [ion binding]; metal-binding site 745277005304 carbohydrate binding site [chemical binding]; other site 745277005305 putative homodimer interface [polypeptide binding]; other site 745277005306 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 745277005307 TM-ABC transporter signature motif; other site 745277005308 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 745277005309 TM-ABC transporter signature motif; other site 745277005310 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 745277005311 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 745277005312 Walker A/P-loop; other site 745277005313 ATP binding site [chemical binding]; other site 745277005314 Q-loop/lid; other site 745277005315 ABC transporter signature motif; other site 745277005316 Walker B; other site 745277005317 D-loop; other site 745277005318 H-loop/switch region; other site 745277005319 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 745277005320 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 745277005321 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 745277005322 ligand binding site [chemical binding]; other site 745277005323 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 745277005324 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 745277005325 inhibitor-cofactor binding pocket; inhibition site 745277005326 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277005327 catalytic residue [active] 745277005328 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 745277005329 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 745277005330 NAD(P) binding site [chemical binding]; other site 745277005331 catalytic residues [active] 745277005332 succinylarginine dihydrolase; Provisional; Region: PRK13281 745277005333 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 745277005334 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 745277005335 putative active site [active] 745277005336 Zn binding site [ion binding]; other site 745277005337 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 745277005338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277005339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277005340 putative substrate translocation pore; other site 745277005341 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 745277005342 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 745277005343 putative ligand binding site [chemical binding]; other site 745277005344 NAD binding site [chemical binding]; other site 745277005345 dimerization interface [polypeptide binding]; other site 745277005346 catalytic site [active] 745277005347 putative hydrolase; Validated; Region: PRK09248 745277005348 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 745277005349 active site 745277005350 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 745277005351 lipoprotein; Provisional; Region: PRK10598 745277005352 glutaredoxin 2; Provisional; Region: PRK10387 745277005353 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 745277005354 C-terminal domain interface [polypeptide binding]; other site 745277005355 GSH binding site (G-site) [chemical binding]; other site 745277005356 catalytic residues [active] 745277005357 putative dimer interface [polypeptide binding]; other site 745277005358 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 745277005359 N-terminal domain interface [polypeptide binding]; other site 745277005360 multidrug resistance protein MdtH; Provisional; Region: PRK11646 745277005361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277005362 putative substrate translocation pore; other site 745277005363 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 745277005364 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 745277005365 hypothetical protein; Provisional; Region: PRK11239 745277005366 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 745277005367 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 745277005368 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 745277005369 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 745277005370 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 745277005371 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 745277005372 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 745277005373 active site 745277005374 HIGH motif; other site 745277005375 KMSK motif region; other site 745277005376 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 745277005377 tRNA binding surface [nucleotide binding]; other site 745277005378 anticodon binding site; other site 745277005379 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 745277005380 putative metal binding site [ion binding]; other site 745277005381 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 745277005382 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 745277005383 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277005384 homodimer interface [polypeptide binding]; other site 745277005385 catalytic residue [active] 745277005386 copper homeostasis protein CutC; Provisional; Region: PRK11572 745277005387 tRNA (mo5U34)-methyltransferase; Region: TIGR00452 745277005388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277005389 S-adenosylmethionine binding site [chemical binding]; other site 745277005390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277005391 S-adenosylmethionine binding site [chemical binding]; other site 745277005392 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 745277005393 Protein of unknown function DUF72; Region: DUF72; cl00777 745277005394 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 745277005395 catalytic triad [active] 745277005396 conserved cis-peptide bond; other site 745277005397 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 745277005398 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 745277005399 dimer interface [polypeptide binding]; other site 745277005400 anticodon binding site; other site 745277005401 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 745277005402 homodimer interface [polypeptide binding]; other site 745277005403 motif 1; other site 745277005404 active site 745277005405 motif 2; other site 745277005406 motif 3; other site 745277005407 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 745277005408 nudix motif; other site 745277005409 hypothetical protein; Validated; Region: PRK00110 745277005410 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 745277005411 active site 745277005412 putative DNA-binding cleft [nucleotide binding]; other site 745277005413 dimer interface [polypeptide binding]; other site 745277005414 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 745277005415 RuvA N terminal domain; Region: RuvA_N; pfam01330 745277005416 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 745277005417 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 745277005418 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 745277005419 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745277005420 Walker A motif; other site 745277005421 ATP binding site [chemical binding]; other site 745277005422 Walker B motif; other site 745277005423 arginine finger; other site 745277005424 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 745277005425 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 745277005426 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 745277005427 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 745277005428 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 745277005429 putative symporter YagG; Provisional; Region: PRK09669 745277005430 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 745277005431 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277005432 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277005433 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 745277005434 putative effector binding pocket; other site 745277005435 putative dimerization interface [polypeptide binding]; other site 745277005436 short chain dehydrogenase; Provisional; Region: PRK06172 745277005437 classical (c) SDRs; Region: SDR_c; cd05233 745277005438 NAD(P) binding site [chemical binding]; other site 745277005439 active site 745277005440 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 745277005441 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 745277005442 active site turn [active] 745277005443 phosphorylation site [posttranslational modification] 745277005444 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 745277005445 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 745277005446 HPr interaction site; other site 745277005447 glycerol kinase (GK) interaction site [polypeptide binding]; other site 745277005448 active site 745277005449 phosphorylation site [posttranslational modification] 745277005450 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 745277005451 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 745277005452 transcriptional antiterminator BglG; Provisional; Region: PRK09772 745277005453 CAT RNA binding domain; Region: CAT_RBD; smart01061 745277005454 PRD domain; Region: PRD; pfam00874 745277005455 PRD domain; Region: PRD; pfam00874 745277005456 L-asparagine permease; Provisional; Region: PRK15049 745277005457 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 745277005458 Transposase IS200 like; Region: Y1_Tnp; pfam01797 745277005459 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 745277005460 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 745277005461 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 745277005462 classical (c) SDRs; Region: SDR_c; cd05233 745277005463 NAD(P) binding site [chemical binding]; other site 745277005464 active site 745277005465 Predicted transcriptional regulators [Transcription]; Region: COG1733 745277005466 Predicted acyl esterases [General function prediction only]; Region: COG2936 745277005467 Putative lysophospholipase; Region: Hydrolase_4; cl19140 745277005468 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 745277005469 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 745277005470 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 745277005471 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277005472 Walker A/P-loop; other site 745277005473 ATP binding site [chemical binding]; other site 745277005474 Q-loop/lid; other site 745277005475 ABC transporter signature motif; other site 745277005476 Walker B; other site 745277005477 D-loop; other site 745277005478 H-loop/switch region; other site 745277005479 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277005480 Walker A/P-loop; other site 745277005481 ATP binding site [chemical binding]; other site 745277005482 Q-loop/lid; other site 745277005483 ABC transporter signature motif; other site 745277005484 Walker B; other site 745277005485 D-loop; other site 745277005486 H-loop/switch region; other site 745277005487 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745277005488 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 745277005489 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 745277005490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277005491 dimer interface [polypeptide binding]; other site 745277005492 conserved gate region; other site 745277005493 putative PBP binding loops; other site 745277005494 ABC-ATPase subunit interface; other site 745277005495 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 745277005496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277005497 dimer interface [polypeptide binding]; other site 745277005498 conserved gate region; other site 745277005499 ABC-ATPase subunit interface; other site 745277005500 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 745277005501 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 745277005502 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 745277005503 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277005504 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 745277005505 dimerization interface [polypeptide binding]; other site 745277005506 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 745277005507 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745277005508 DNA-binding site [nucleotide binding]; DNA binding site 745277005509 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 745277005510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277005511 homodimer interface [polypeptide binding]; other site 745277005512 catalytic residue [active] 745277005513 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 745277005514 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 745277005515 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 745277005516 active site 745277005517 HIGH motif; other site 745277005518 KMSKS motif; other site 745277005519 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 745277005520 tRNA binding surface [nucleotide binding]; other site 745277005521 anticodon binding site; other site 745277005522 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 745277005523 dimer interface [polypeptide binding]; other site 745277005524 putative tRNA-binding site [nucleotide binding]; other site 745277005525 antiporter inner membrane protein; Provisional; Region: PRK11670 745277005526 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 745277005527 Walker A motif; other site 745277005528 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 745277005529 ATP-binding site [chemical binding]; other site 745277005530 Sugar specificity; other site 745277005531 Pyrimidine base specificity; other site 745277005532 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 745277005533 trimer interface [polypeptide binding]; other site 745277005534 active site 745277005535 putative assembly protein; Provisional; Region: PRK10833 745277005536 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 745277005537 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 745277005538 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 745277005539 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 745277005540 Transporter associated domain; Region: CorC_HlyC; smart01091 745277005541 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 745277005542 active site 745277005543 tetramer interface; other site 745277005544 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 745277005545 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 745277005546 NAD binding site [chemical binding]; other site 745277005547 substrate binding site [chemical binding]; other site 745277005548 homodimer interface [polypeptide binding]; other site 745277005549 active site 745277005550 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 745277005551 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 745277005552 NADP binding site [chemical binding]; other site 745277005553 active site 745277005554 putative substrate binding site [chemical binding]; other site 745277005555 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 745277005556 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 745277005557 substrate binding site; other site 745277005558 tetramer interface; other site 745277005559 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 745277005560 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 745277005561 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 745277005562 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 745277005563 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 745277005564 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 745277005565 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 745277005566 metal binding site [ion binding]; metal-binding site 745277005567 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 745277005568 substrate binding site [chemical binding]; other site 745277005569 glutamase interaction surface [polypeptide binding]; other site 745277005570 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 745277005571 catalytic residues [active] 745277005572 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 745277005573 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 745277005574 putative active site [active] 745277005575 oxyanion strand; other site 745277005576 catalytic triad [active] 745277005577 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 745277005578 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745277005579 active site 745277005580 motif I; other site 745277005581 motif II; other site 745277005582 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 745277005583 putative active site pocket [active] 745277005584 4-fold oligomerization interface [polypeptide binding]; other site 745277005585 metal binding residues [ion binding]; metal-binding site 745277005586 3-fold/trimer interface [polypeptide binding]; other site 745277005587 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 745277005588 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 745277005589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277005590 homodimer interface [polypeptide binding]; other site 745277005591 catalytic residue [active] 745277005592 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 745277005593 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 745277005594 NAD binding site [chemical binding]; other site 745277005595 dimerization interface [polypeptide binding]; other site 745277005596 product binding site; other site 745277005597 substrate binding site [chemical binding]; other site 745277005598 zinc binding site [ion binding]; other site 745277005599 catalytic residues [active] 745277005600 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 745277005601 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 745277005602 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 745277005603 histidine operon leader; IMG reference gene:2506708869 745277005604 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 745277005605 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 745277005606 putative NAD(P) binding site [chemical binding]; other site 745277005607 transcriptional activator FlhD; Provisional; Region: PRK02909 745277005608 transcriptional activator FlhC; Provisional; Region: PRK12722 745277005609 flagellar motor protein MotA; Validated; Region: PRK09110 745277005610 flagellar motor protein MotB; Validated; Region: motB; PRK09041 745277005611 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 745277005612 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 745277005613 ligand binding site [chemical binding]; other site 745277005614 chemotaxis protein CheA; Provisional; Region: PRK10547 745277005615 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 745277005616 putative binding surface; other site 745277005617 active site 745277005618 CheY binding; Region: CheY-binding; pfam09078 745277005619 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 745277005620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277005621 ATP binding site [chemical binding]; other site 745277005622 Mg2+ binding site [ion binding]; other site 745277005623 G-X-G motif; other site 745277005624 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 745277005625 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 745277005626 putative CheA interaction surface; other site 745277005627 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 745277005628 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 745277005629 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 745277005630 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 745277005631 putative transposase OrfB; Reviewed; Region: PHA02517 745277005632 HTH-like domain; Region: HTH_21; pfam13276 745277005633 Integrase core domain; Region: rve; pfam00665 745277005634 Integrase core domain; Region: rve_2; pfam13333 745277005635 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-F; cd09718 745277005636 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 745277005637 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 745277005638 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09735 745277005639 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09736 745277005640 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 745277005641 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739 745277005642 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 745277005643 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 745277005644 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 745277005645 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 745277005646 conserved cys residue [active] 745277005647 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277005648 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277005649 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 745277005650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277005651 putative substrate translocation pore; other site 745277005652 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 745277005653 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 745277005654 dimer interface [polypeptide binding]; other site 745277005655 ligand binding site [chemical binding]; other site 745277005656 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 745277005657 dimerization interface [polypeptide binding]; other site 745277005658 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 745277005659 dimer interface [polypeptide binding]; other site 745277005660 putative CheW interface [polypeptide binding]; other site 745277005661 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 745277005662 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 745277005663 dimer interface [polypeptide binding]; other site 745277005664 ligand binding site [chemical binding]; other site 745277005665 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 745277005666 dimerization interface [polypeptide binding]; other site 745277005667 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 745277005668 dimer interface [polypeptide binding]; other site 745277005669 putative CheW interface [polypeptide binding]; other site 745277005670 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 745277005671 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 745277005672 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277005673 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 745277005674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277005675 active site 745277005676 phosphorylation site [posttranslational modification] 745277005677 intermolecular recognition site; other site 745277005678 dimerization interface [polypeptide binding]; other site 745277005679 CheB methylesterase; Region: CheB_methylest; pfam01339 745277005680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277005681 active site 745277005682 phosphorylation site [posttranslational modification] 745277005683 intermolecular recognition site; other site 745277005684 dimerization interface [polypeptide binding]; other site 745277005685 chemotaxis regulator CheZ; Provisional; Region: PRK11166 745277005686 FlhB HrpN YscU SpaS Family; Region: Bac_export_2; cl19167 745277005687 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 745277005688 Flagellar protein FlhE; Region: FlhE; pfam06366 745277005689 FlgN protein; Region: FlgN; cl09176 745277005690 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 745277005691 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 745277005692 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 745277005693 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 745277005694 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 745277005695 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 745277005696 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 745277005697 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 745277005698 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 745277005699 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 745277005700 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 745277005701 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 745277005702 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 745277005703 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 745277005704 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 745277005705 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 745277005706 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 745277005707 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 745277005708 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 745277005709 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 745277005710 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 745277005711 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 745277005712 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 745277005713 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 745277005714 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 745277005715 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 745277005716 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 745277005717 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 745277005718 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 745277005719 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 745277005720 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 745277005721 hypothetical protein; Provisional; Region: PRK10711 745277005722 hypothetical protein; Provisional; Region: PRK01821 745277005723 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 745277005724 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 745277005725 putative transposase OrfB; Reviewed; Region: PHA02517 745277005726 HTH-like domain; Region: HTH_21; pfam13276 745277005727 Integrase core domain; Region: rve; pfam00665 745277005728 Integrase core domain; Region: rve_2; pfam13333 745277005729 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 745277005730 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 745277005731 Walker A/P-loop; other site 745277005732 ATP binding site [chemical binding]; other site 745277005733 Q-loop/lid; other site 745277005734 ABC transporter signature motif; other site 745277005735 Walker B; other site 745277005736 D-loop; other site 745277005737 H-loop/switch region; other site 745277005738 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 745277005739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277005740 dimer interface [polypeptide binding]; other site 745277005741 conserved gate region; other site 745277005742 putative PBP binding loops; other site 745277005743 ABC-ATPase subunit interface; other site 745277005744 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745277005745 Coenzyme A binding pocket [chemical binding]; other site 745277005746 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 745277005747 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745277005748 substrate binding pocket [chemical binding]; other site 745277005749 membrane-bound complex binding site; other site 745277005750 hinge residues; other site 745277005751 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 745277005752 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 745277005753 metal binding site [ion binding]; metal-binding site 745277005754 dimer interface [polypeptide binding]; other site 745277005755 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 745277005756 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 745277005757 active site 745277005758 non-prolyl cis peptide bond; other site 745277005759 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 745277005760 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 745277005761 NADP binding site [chemical binding]; other site 745277005762 dimer interface [polypeptide binding]; other site 745277005763 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 745277005764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277005765 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 745277005766 active site 745277005767 phosphorylation site [posttranslational modification] 745277005768 intermolecular recognition site; other site 745277005769 dimerization interface [polypeptide binding]; other site 745277005770 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 745277005771 Putative lysophospholipase; Region: Hydrolase_4; cl19140 745277005772 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 745277005773 active site 745277005774 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 745277005775 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 745277005776 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277005777 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277005778 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 745277005779 dimerization interface [polypeptide binding]; other site 745277005780 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 745277005781 Phosphotransferase enzyme family; Region: APH; pfam01636 745277005782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277005783 Major Facilitator Superfamily; Region: MFS_1; pfam07690 745277005784 putative substrate translocation pore; other site 745277005785 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 745277005786 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 745277005787 HlyD family secretion protein; Region: HlyD_3; pfam13437 745277005788 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 745277005789 Fusaric acid resistance protein family; Region: FUSC; pfam04632 745277005790 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 745277005791 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 745277005792 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 745277005793 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277005794 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 745277005795 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 745277005796 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 745277005797 heme binding site [chemical binding]; other site 745277005798 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 745277005799 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 745277005800 FAD binding domain; Region: FAD_binding_4; pfam01565 745277005801 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 745277005802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277005803 dimer interface [polypeptide binding]; other site 745277005804 conserved gate region; other site 745277005805 putative PBP binding loops; other site 745277005806 ABC-ATPase subunit interface; other site 745277005807 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 745277005808 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 745277005809 Walker A/P-loop; other site 745277005810 ATP binding site [chemical binding]; other site 745277005811 Q-loop/lid; other site 745277005812 ABC transporter signature motif; other site 745277005813 Walker B; other site 745277005814 D-loop; other site 745277005815 H-loop/switch region; other site 745277005816 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 745277005817 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 745277005818 Creatinine amidohydrolase; Region: Creatininase; pfam02633 745277005819 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 745277005820 homotrimer interaction site [polypeptide binding]; other site 745277005821 putative active site [active] 745277005822 cytosine deaminase-like protein; Validated; Region: PRK07583 745277005823 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 745277005824 active site 745277005825 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 745277005826 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 745277005827 FMN-binding pocket [chemical binding]; other site 745277005828 flavin binding motif; other site 745277005829 phosphate binding motif [ion binding]; other site 745277005830 beta-alpha-beta structure motif; other site 745277005831 NAD binding pocket [chemical binding]; other site 745277005832 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 745277005833 catalytic loop [active] 745277005834 iron binding site [ion binding]; other site 745277005835 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277005836 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277005837 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 745277005838 dimerization interface [polypeptide binding]; other site 745277005839 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 745277005840 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 745277005841 amidohydrolase; Provisional; Region: PRK12393 745277005842 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 745277005843 active site 745277005844 putative substrate binding pocket [chemical binding]; other site 745277005845 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 745277005846 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 745277005847 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 745277005848 Putative motility protein; Region: YjfB_motility; pfam14070 745277005849 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 745277005850 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277005851 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277005852 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 745277005853 putative effector binding pocket; other site 745277005854 putative dimerization interface [polypeptide binding]; other site 745277005855 short chain dehydrogenase; Provisional; Region: PRK12744 745277005856 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745277005857 NAD(P) binding site [chemical binding]; other site 745277005858 active site 745277005859 Predicted transcriptional regulators [Transcription]; Region: COG1733 745277005860 short chain dehydrogenase; Provisional; Region: PRK06500 745277005861 classical (c) SDRs; Region: SDR_c; cd05233 745277005862 NAD(P) binding site [chemical binding]; other site 745277005863 active site 745277005864 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 745277005865 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277005866 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277005867 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 745277005868 putative effector binding pocket; other site 745277005869 putative dimerization interface [polypeptide binding]; other site 745277005870 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 745277005871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277005872 putative substrate translocation pore; other site 745277005873 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 745277005874 Putative lysophospholipase; Region: Hydrolase_4; cl19140 745277005875 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 745277005876 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 745277005877 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 745277005878 Helix-turn-helix domain; Region: HTH_18; pfam12833 745277005879 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 745277005880 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 745277005881 N-terminal plug; other site 745277005882 ligand-binding site [chemical binding]; other site 745277005883 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 745277005884 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 745277005885 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 745277005886 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 745277005887 ABC-ATPase subunit interface; other site 745277005888 dimer interface [polypeptide binding]; other site 745277005889 putative PBP binding regions; other site 745277005890 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 745277005891 ABC-ATPase subunit interface; other site 745277005892 dimer interface [polypeptide binding]; other site 745277005893 putative PBP binding regions; other site 745277005894 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 745277005895 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 745277005896 intersubunit interface [polypeptide binding]; other site 745277005897 OsmC-like protein; Region: OsmC; cl00767 745277005898 OsmC-like protein; Region: OsmC; pfam02566 745277005899 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 745277005900 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745277005901 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 745277005902 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 745277005903 catalytic residues [active] 745277005904 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 745277005905 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 745277005906 substrate binding site [chemical binding]; other site 745277005907 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 745277005908 FMN binding site [chemical binding]; other site 745277005909 active site 745277005910 substrate binding site [chemical binding]; other site 745277005911 catalytic residue [active] 745277005912 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 745277005913 catalytic residues [active] 745277005914 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 745277005915 classical (c) SDRs; Region: SDR_c; cd05233 745277005916 NAD(P) binding site [chemical binding]; other site 745277005917 active site 745277005918 Putative lysophospholipase; Region: Hydrolase_4; cl19140 745277005919 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 745277005920 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 745277005921 Thioredoxin; Region: Thioredoxin_9; pfam14595 745277005922 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 745277005923 EamA-like transporter family; Region: EamA; pfam00892 745277005924 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 745277005925 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 745277005926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277005927 homodimer interface [polypeptide binding]; other site 745277005928 catalytic residue [active] 745277005929 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 745277005930 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 745277005931 dimerization domain [polypeptide binding]; other site 745277005932 dimer interface [polypeptide binding]; other site 745277005933 catalytic residues [active] 745277005934 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 745277005935 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 745277005936 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 745277005937 active site 745277005938 phosphorylation site [posttranslational modification] 745277005939 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 745277005940 active site 745277005941 P-loop; other site 745277005942 phosphorylation site [posttranslational modification] 745277005943 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 745277005944 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 745277005945 substrate binding site [chemical binding]; other site 745277005946 hexamer interface [polypeptide binding]; other site 745277005947 metal binding site [ion binding]; metal-binding site 745277005948 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 745277005949 classical (c) SDRs; Region: SDR_c; cd05233 745277005950 NAD(P) binding site [chemical binding]; other site 745277005951 active site 745277005952 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 745277005953 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 745277005954 tetramer interface [polypeptide binding]; other site 745277005955 active site 745277005956 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 745277005957 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 745277005958 Walker A/P-loop; other site 745277005959 ATP binding site [chemical binding]; other site 745277005960 Q-loop/lid; other site 745277005961 ABC transporter signature motif; other site 745277005962 Walker B; other site 745277005963 D-loop; other site 745277005964 H-loop/switch region; other site 745277005965 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 745277005966 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 745277005967 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 745277005968 ligand binding site [chemical binding]; other site 745277005969 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 745277005970 TM-ABC transporter signature motif; other site 745277005971 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 745277005972 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 745277005973 nucleotide binding site [chemical binding]; other site 745277005974 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277005975 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277005976 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 745277005977 putative effector binding pocket; other site 745277005978 putative dimerization interface [polypeptide binding]; other site 745277005979 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 745277005980 homotrimer interaction site [polypeptide binding]; other site 745277005981 putative active site [active] 745277005982 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 745277005983 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 745277005984 NAD(P) binding site [chemical binding]; other site 745277005985 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277005986 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277005987 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 745277005988 putative effector binding pocket; other site 745277005989 dimerization interface [polypeptide binding]; other site 745277005990 short chain dehydrogenase; Provisional; Region: PRK06500 745277005991 classical (c) SDRs; Region: SDR_c; cd05233 745277005992 NAD(P) binding site [chemical binding]; other site 745277005993 active site 745277005994 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 745277005995 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 745277005996 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 745277005997 N-terminal domain interface [polypeptide binding]; other site 745277005998 dimer interface [polypeptide binding]; other site 745277005999 substrate binding pocket (H-site) [chemical binding]; other site 745277006000 Cupin; Region: Cupin_6; pfam12852 745277006001 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277006002 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 745277006003 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277006004 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 745277006005 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 745277006006 active site 745277006007 catalytic tetrad [active] 745277006008 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 745277006009 Protein of unknown function, DUF606; Region: DUF606; pfam04657 745277006010 hypothetical protein; Provisional; Region: PRK08204 745277006011 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 745277006012 active site 745277006013 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277006014 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277006015 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 745277006016 putative effector binding pocket; other site 745277006017 putative dimerization interface [polypeptide binding]; other site 745277006018 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 745277006019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277006020 putative substrate translocation pore; other site 745277006021 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 745277006022 Helix-turn-helix domain; Region: HTH_18; pfam12833 745277006023 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277006024 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 745277006025 FMN binding site [chemical binding]; other site 745277006026 active site 745277006027 substrate binding site [chemical binding]; other site 745277006028 catalytic residue [active] 745277006029 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277006030 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277006031 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 745277006032 dimerization interface [polypeptide binding]; other site 745277006033 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 745277006034 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 745277006035 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277006036 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277006037 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 745277006038 putative effector binding pocket; other site 745277006039 dimerization interface [polypeptide binding]; other site 745277006040 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 745277006041 catalytic core [active] 745277006042 integrase; Provisional; Region: PRK09692 745277006043 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 745277006044 active site 745277006045 Int/Topo IB signature motif; other site 745277006046 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 745277006047 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 745277006048 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 745277006049 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 745277006050 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 745277006051 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 745277006052 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 745277006053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277006054 dimer interface [polypeptide binding]; other site 745277006055 conserved gate region; other site 745277006056 putative PBP binding loops; other site 745277006057 ABC-ATPase subunit interface; other site 745277006058 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 745277006059 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 745277006060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277006061 dimer interface [polypeptide binding]; other site 745277006062 conserved gate region; other site 745277006063 putative PBP binding loops; other site 745277006064 ABC-ATPase subunit interface; other site 745277006065 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 745277006066 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277006067 Walker A/P-loop; other site 745277006068 ATP binding site [chemical binding]; other site 745277006069 Q-loop/lid; other site 745277006070 ABC transporter signature motif; other site 745277006071 Walker B; other site 745277006072 D-loop; other site 745277006073 H-loop/switch region; other site 745277006074 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745277006075 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 745277006076 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277006077 Walker A/P-loop; other site 745277006078 ATP binding site [chemical binding]; other site 745277006079 Q-loop/lid; other site 745277006080 ABC transporter signature motif; other site 745277006081 Walker B; other site 745277006082 D-loop; other site 745277006083 H-loop/switch region; other site 745277006084 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745277006085 diaminopimelate epimerase; Provisional; Region: PRK13577 745277006086 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 745277006087 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 745277006088 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 745277006089 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 745277006090 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 745277006091 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 745277006092 nucleotide binding site [chemical binding]; other site 745277006093 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 745277006094 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 745277006095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277006096 dimer interface [polypeptide binding]; other site 745277006097 conserved gate region; other site 745277006098 putative PBP binding loops; other site 745277006099 ABC-ATPase subunit interface; other site 745277006100 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 745277006101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277006102 dimer interface [polypeptide binding]; other site 745277006103 conserved gate region; other site 745277006104 putative PBP binding loops; other site 745277006105 ABC-ATPase subunit interface; other site 745277006106 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 745277006107 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 745277006108 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 745277006109 Transcriptional regulators [Transcription]; Region: MarR; COG1846 745277006110 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 745277006111 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 745277006112 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 745277006113 Uncharacterized conserved protein [Function unknown]; Region: COG5476 745277006114 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 745277006115 MlrC C-terminus; Region: MlrC_C; pfam07171 745277006116 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 745277006117 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277006118 Walker A/P-loop; other site 745277006119 ATP binding site [chemical binding]; other site 745277006120 Q-loop/lid; other site 745277006121 ABC transporter signature motif; other site 745277006122 Walker B; other site 745277006123 D-loop; other site 745277006124 H-loop/switch region; other site 745277006125 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745277006126 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277006127 Walker A/P-loop; other site 745277006128 ATP binding site [chemical binding]; other site 745277006129 Q-loop/lid; other site 745277006130 ABC transporter signature motif; other site 745277006131 Walker B; other site 745277006132 D-loop; other site 745277006133 H-loop/switch region; other site 745277006134 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 745277006135 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 745277006136 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 745277006137 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 745277006138 putative active site [active] 745277006139 putative substrate binding site [chemical binding]; other site 745277006140 putative cosubstrate binding site; other site 745277006141 catalytic site [active] 745277006142 hypothetical protein; Provisional; Region: PRK01617 745277006143 SEC-C motif; Region: SEC-C; cl19389 745277006144 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 745277006145 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 745277006146 active site 745277006147 nucleophile elbow; other site 745277006148 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277006149 active site 745277006150 response regulator of RpoS; Provisional; Region: PRK10693 745277006151 phosphorylation site [posttranslational modification] 745277006152 intermolecular recognition site; other site 745277006153 dimerization interface [polypeptide binding]; other site 745277006154 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 745277006155 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 745277006156 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 745277006157 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 745277006158 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 745277006159 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 745277006160 putative NAD(P) binding site [chemical binding]; other site 745277006161 active site 745277006162 putative substrate binding site [chemical binding]; other site 745277006163 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 745277006164 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 745277006165 thymidine kinase; Provisional; Region: PRK04296 745277006166 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 745277006167 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 745277006168 putative catalytic cysteine [active] 745277006169 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 745277006170 putative active site [active] 745277006171 metal binding site [ion binding]; metal-binding site 745277006172 hypothetical protein; Provisional; Region: PRK11111 745277006173 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 745277006174 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 745277006175 peptide binding site [polypeptide binding]; other site 745277006176 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 745277006177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277006178 dimer interface [polypeptide binding]; other site 745277006179 conserved gate region; other site 745277006180 putative PBP binding loops; other site 745277006181 ABC-ATPase subunit interface; other site 745277006182 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 745277006183 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 745277006184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277006185 dimer interface [polypeptide binding]; other site 745277006186 conserved gate region; other site 745277006187 putative PBP binding loops; other site 745277006188 ABC-ATPase subunit interface; other site 745277006189 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 745277006190 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277006191 Walker A/P-loop; other site 745277006192 ATP binding site [chemical binding]; other site 745277006193 Q-loop/lid; other site 745277006194 ABC transporter signature motif; other site 745277006195 Walker B; other site 745277006196 D-loop; other site 745277006197 H-loop/switch region; other site 745277006198 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745277006199 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 745277006200 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277006201 Walker A/P-loop; other site 745277006202 ATP binding site [chemical binding]; other site 745277006203 Q-loop/lid; other site 745277006204 ABC transporter signature motif; other site 745277006205 Walker B; other site 745277006206 D-loop; other site 745277006207 H-loop/switch region; other site 745277006208 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745277006209 dsDNA-mimic protein; Reviewed; Region: PRK05094 745277006210 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 745277006211 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 745277006212 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 745277006213 putative active site [active] 745277006214 catalytic site [active] 745277006215 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 745277006216 putative active site [active] 745277006217 catalytic site [active] 745277006218 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 745277006219 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 745277006220 YciI-like protein; Reviewed; Region: PRK11370 745277006221 transport protein TonB; Provisional; Region: PRK10819 745277006222 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 745277006223 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 745277006224 intracellular septation protein A; Reviewed; Region: PRK00259 745277006225 hypothetical protein; Provisional; Region: PRK02868 745277006226 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 745277006227 outer membrane protein W; Provisional; Region: PRK10959 745277006228 BON domain; Region: BON; pfam04972 745277006229 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 745277006230 substrate binding site [chemical binding]; other site 745277006231 active site 745277006232 catalytic residues [active] 745277006233 heterodimer interface [polypeptide binding]; other site 745277006234 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 745277006235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277006236 catalytic residue [active] 745277006237 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 745277006238 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 745277006239 active site 745277006240 ribulose/triose binding site [chemical binding]; other site 745277006241 phosphate binding site [ion binding]; other site 745277006242 substrate (anthranilate) binding pocket [chemical binding]; other site 745277006243 product (indole) binding pocket [chemical binding]; other site 745277006244 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 745277006245 active site 745277006246 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 745277006247 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 745277006248 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 745277006249 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 745277006250 Glutamine amidotransferase class-I; Region: GATase; pfam00117 745277006251 glutamine binding [chemical binding]; other site 745277006252 catalytic triad [active] 745277006253 anthranilate synthase component I; Provisional; Region: PRK13564 745277006254 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 745277006255 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 745277006256 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 745277006257 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 745277006258 active site 745277006259 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 745277006260 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 745277006261 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 745277006262 RNA binding surface [nucleotide binding]; other site 745277006263 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 745277006264 probable active site [active] 745277006265 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 745277006266 homotrimer interface [polypeptide binding]; other site 745277006267 Walker A motif; other site 745277006268 GTP binding site [chemical binding]; other site 745277006269 Walker B motif; other site 745277006270 cobalamin synthase; Reviewed; Region: cobS; PRK00235 745277006271 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 745277006272 catalytic core [active] 745277006273 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 745277006274 putative dimer interface [polypeptide binding]; other site 745277006275 active site pocket [active] 745277006276 putative cataytic base [active] 745277006277 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 745277006278 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 745277006279 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 745277006280 homodimer interface [polypeptide binding]; other site 745277006281 Walker A motif; other site 745277006282 ATP binding site [chemical binding]; other site 745277006283 hydroxycobalamin binding site [chemical binding]; other site 745277006284 Walker B motif; other site 745277006285 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 745277006286 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 745277006287 NADP binding site [chemical binding]; other site 745277006288 homodimer interface [polypeptide binding]; other site 745277006289 active site 745277006290 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 745277006291 putative inner membrane peptidase; Provisional; Region: PRK11778 745277006292 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 745277006293 tandem repeat interface [polypeptide binding]; other site 745277006294 oligomer interface [polypeptide binding]; other site 745277006295 active site residues [active] 745277006296 hypothetical protein; Provisional; Region: PRK11037 745277006297 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 745277006298 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 745277006299 active site 745277006300 interdomain interaction site; other site 745277006301 putative metal-binding site [ion binding]; other site 745277006302 nucleotide binding site [chemical binding]; other site 745277006303 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 745277006304 domain I; other site 745277006305 DNA binding groove [nucleotide binding] 745277006306 phosphate binding site [ion binding]; other site 745277006307 domain II; other site 745277006308 domain III; other site 745277006309 nucleotide binding site [chemical binding]; other site 745277006310 catalytic site [active] 745277006311 domain IV; other site 745277006312 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 745277006313 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 745277006314 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 745277006315 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 745277006316 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 745277006317 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277006318 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 745277006319 substrate binding site [chemical binding]; other site 745277006320 putative dimerization interface [polypeptide binding]; other site 745277006321 aconitate hydratase; Validated; Region: PRK09277 745277006322 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 745277006323 substrate binding site [chemical binding]; other site 745277006324 ligand binding site [chemical binding]; other site 745277006325 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 745277006326 substrate binding site [chemical binding]; other site 745277006327 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 745277006328 dimerization interface [polypeptide binding]; other site 745277006329 active site 745277006330 phosphatidylglycerophosphatase B; Provisional; Region: PRK10699 745277006331 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 745277006332 active site 745277006333 Predicted membrane protein [Function unknown]; Region: COG3771 745277006334 tetratricopeptide repeat protein; Provisional; Region: PRK11788 745277006335 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 745277006336 TPR motif; other site 745277006337 binding surface 745277006338 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 745277006339 binding surface 745277006340 TPR motif; other site 745277006341 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 745277006342 active site 745277006343 dimer interface [polypeptide binding]; other site 745277006344 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 745277006345 putative rRNA binding site [nucleotide binding]; other site 745277006346 lipoprotein; Provisional; Region: PRK10540 745277006347 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 745277006348 intersubunit interface [polypeptide binding]; other site 745277006349 active site 745277006350 Zn2+ binding site [ion binding]; other site 745277006351 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 745277006352 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 745277006353 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 745277006354 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 745277006355 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 745277006356 dimer interface [polypeptide binding]; other site 745277006357 active site 745277006358 glycine loop; other site 745277006359 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 745277006360 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 745277006361 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 745277006362 active site 745277006363 intersubunit interactions; other site 745277006364 catalytic residue [active] 745277006365 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 745277006366 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 745277006367 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 745277006368 dimer interface [polypeptide binding]; other site 745277006369 active site 745277006370 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 745277006371 Pirin-related protein [General function prediction only]; Region: COG1741 745277006372 Pirin; Region: Pirin; pfam02678 745277006373 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277006374 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277006375 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 745277006376 putative effector binding pocket; other site 745277006377 dimerization interface [polypeptide binding]; other site 745277006378 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 745277006379 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 745277006380 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277006381 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745277006382 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 745277006383 Walker A/P-loop; other site 745277006384 ATP binding site [chemical binding]; other site 745277006385 Q-loop/lid; other site 745277006386 ABC transporter signature motif; other site 745277006387 Walker B; other site 745277006388 D-loop; other site 745277006389 H-loop/switch region; other site 745277006390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277006391 dimer interface [polypeptide binding]; other site 745277006392 conserved gate region; other site 745277006393 putative PBP binding loops; other site 745277006394 ABC-ATPase subunit interface; other site 745277006395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277006396 dimer interface [polypeptide binding]; other site 745277006397 conserved gate region; other site 745277006398 putative PBP binding loops; other site 745277006399 ABC-ATPase subunit interface; other site 745277006400 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 745277006401 Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221 745277006402 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 745277006403 active sites [active] 745277006404 tetramer interface [polypeptide binding]; other site 745277006405 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 745277006406 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 745277006407 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 745277006408 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 745277006409 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 745277006410 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 745277006411 substrate binding site [chemical binding]; other site 745277006412 oxyanion hole (OAH) forming residues; other site 745277006413 trimer interface [polypeptide binding]; other site 745277006414 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 745277006415 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745277006416 DNA-binding site [nucleotide binding]; DNA binding site 745277006417 UTRA domain; Region: UTRA; pfam07702 745277006418 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 745277006419 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 745277006420 putative NAD(P) binding site [chemical binding]; other site 745277006421 putative substrate binding site [chemical binding]; other site 745277006422 catalytic Zn binding site [ion binding]; other site 745277006423 structural Zn binding site [ion binding]; other site 745277006424 dimer interface [polypeptide binding]; other site 745277006425 EamA-like transporter family; Region: EamA; pfam00892 745277006426 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 745277006427 EamA-like transporter family; Region: EamA; pfam00892 745277006428 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 745277006429 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745277006430 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 745277006431 phosphogluconate dehydratase; Validated; Region: PRK09054 745277006432 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 745277006433 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 745277006434 ligand binding site; other site 745277006435 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 745277006436 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 745277006437 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 745277006438 Ligand binding site; other site 745277006439 Putative Catalytic site; other site 745277006440 DXD motif; other site 745277006441 L,D-transpeptidase; Provisional; Region: PRK10260 745277006442 Lysin motif; Region: LysM; smart00257 745277006443 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 745277006444 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 745277006445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277006446 putative substrate translocation pore; other site 745277006447 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 745277006448 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 745277006449 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 745277006450 HlyD family secretion protein; Region: HlyD_3; pfam13437 745277006451 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 745277006452 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745277006453 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 745277006454 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 745277006455 N-terminal plug; other site 745277006456 ligand-binding site [chemical binding]; other site 745277006457 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 745277006458 Methyltransferase domain; Region: Methyltransf_31; pfam13847 745277006459 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 745277006460 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; cl08459 745277006461 Chromate transporter; Region: Chromate_transp; pfam02417 745277006462 Chromate transporter; Region: Chromate_transp; pfam02417 745277006463 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277006464 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277006465 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 745277006466 putative dimerization interface [polypeptide binding]; other site 745277006467 putative substrate binding pocket [chemical binding]; other site 745277006468 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 745277006469 dimerization interface [polypeptide binding]; other site 745277006470 putative DNA binding site [nucleotide binding]; other site 745277006471 putative Zn2+ binding site [ion binding]; other site 745277006472 elongation factor G; Reviewed; Region: PRK00007 745277006473 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 745277006474 G1 box; other site 745277006475 putative GEF interaction site [polypeptide binding]; other site 745277006476 GTP/Mg2+ binding site [chemical binding]; other site 745277006477 Switch I region; other site 745277006478 G2 box; other site 745277006479 G3 box; other site 745277006480 Switch II region; other site 745277006481 G4 box; other site 745277006482 G5 box; other site 745277006483 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 745277006484 Elongation Factor G, domain II; Region: EFG_II; pfam14492 745277006485 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 745277006486 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 745277006487 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 745277006488 CcdB protein; Region: CcdB; cl03380 745277006489 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 745277006490 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 745277006491 YadA-like C-terminal region; Region: YadA_anchor; pfam03895 745277006492 EthD domain; Region: EthD; cl17553 745277006493 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 745277006494 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 745277006495 ABC-ATPase subunit interface; other site 745277006496 dimer interface [polypeptide binding]; other site 745277006497 putative PBP binding regions; other site 745277006498 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 745277006499 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 745277006500 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 745277006501 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 745277006502 metal binding site [ion binding]; metal-binding site 745277006503 putative peptidase; Provisional; Region: PRK11649 745277006504 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 745277006505 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 745277006506 Peptidase family M23; Region: Peptidase_M23; pfam01551 745277006507 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 745277006508 putative acyl-acceptor binding pocket; other site 745277006509 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 745277006510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277006511 putative substrate translocation pore; other site 745277006512 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 745277006513 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 745277006514 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 745277006515 IucA / IucC family; Region: IucA_IucC; pfam04183 745277006516 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 745277006517 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 745277006518 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 745277006519 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 745277006520 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277006521 catalytic residue [active] 745277006522 pyruvate kinase; Provisional; Region: PRK05826 745277006523 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 745277006524 domain interfaces; other site 745277006525 active site 745277006526 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 745277006527 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 745277006528 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 745277006529 putative active site [active] 745277006530 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 745277006531 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 745277006532 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 745277006533 Entner-Doudoroff aldolase; Region: eda; TIGR01182 745277006534 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 745277006535 active site 745277006536 intersubunit interface [polypeptide binding]; other site 745277006537 catalytic residue [active] 745277006538 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 745277006539 homotrimer interaction site [polypeptide binding]; other site 745277006540 putative active site [active] 745277006541 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 745277006542 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 745277006543 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 745277006544 Glycoprotease family; Region: Peptidase_M22; pfam00814 745277006545 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 745277006546 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 745277006547 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 745277006548 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 745277006549 acyl-activating enzyme (AAE) consensus motif; other site 745277006550 putative AMP binding site [chemical binding]; other site 745277006551 putative active site [active] 745277006552 putative CoA binding site [chemical binding]; other site 745277006553 ribonuclease D; Provisional; Region: PRK10829 745277006554 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 745277006555 catalytic site [active] 745277006556 putative active site [active] 745277006557 putative substrate binding site [chemical binding]; other site 745277006558 HRDC domain; Region: HRDC; pfam00570 745277006559 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 745277006560 cell division inhibitor MinD; Provisional; Region: PRK10818 745277006561 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 745277006562 P-loop; other site 745277006563 ADP binding residues [chemical binding]; other site 745277006564 Switch I; other site 745277006565 Switch II; other site 745277006566 septum formation inhibitor; Reviewed; Region: minC; PRK03511 745277006567 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 745277006568 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 745277006569 YcgL domain; Region: YcgL; cl01189 745277006570 lytic murein transglycosylase; Region: MltB_2; TIGR02283 745277006571 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 745277006572 N-acetyl-D-glucosamine binding site [chemical binding]; other site 745277006573 hypothetical protein; Provisional; Region: PRK10691 745277006574 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 745277006575 hypothetical protein; Provisional; Region: PRK05170 745277006576 anti-RssB factor; Provisional; Region: PRK10244 745277006577 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 745277006578 disulfide bond formation protein B; Provisional; Region: PRK01749 745277006579 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 745277006580 fatty acid metabolism regulator; Provisional; Region: PRK04984 745277006581 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745277006582 DNA-binding site [nucleotide binding]; DNA binding site 745277006583 FadR C-terminal domain; Region: FadR_C; pfam07840 745277006584 SpoVR family protein; Provisional; Region: PRK11767 745277006585 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 745277006586 Putative lysophospholipase; Region: Hydrolase_4; cl19140 745277006587 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 745277006588 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 745277006589 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 745277006590 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 745277006591 alanine racemase; Reviewed; Region: dadX; PRK03646 745277006592 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 745277006593 active site 745277006594 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 745277006595 substrate binding site [chemical binding]; other site 745277006596 catalytic residues [active] 745277006597 dimer interface [polypeptide binding]; other site 745277006598 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 745277006599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277006600 putative substrate translocation pore; other site 745277006601 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 745277006602 homodimer interface [polypeptide binding]; other site 745277006603 NAD binding pocket [chemical binding]; other site 745277006604 ATP binding pocket [chemical binding]; other site 745277006605 Mg binding site [ion binding]; other site 745277006606 active-site loop [active] 745277006607 Protein of unknown function, DUF481; Region: DUF481; cl01213 745277006608 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 745277006609 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 745277006610 Surface antigen; Region: Bac_surface_Ag; pfam01103 745277006611 haemagglutination activity domain; Region: Haemagg_act; pfam05860 745277006612 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 745277006613 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 745277006614 Protein of unknown function (DUF342); Region: DUF342; cl19219 745277006615 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 745277006616 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 745277006617 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 745277006618 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 745277006619 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 745277006620 Uncharacterized conserved protein [Function unknown]; Region: COG2718 745277006621 PrkA family serine protein kinase; Provisional; Region: PRK15455 745277006622 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745277006623 Walker A motif; other site 745277006624 ATP binding site [chemical binding]; other site 745277006625 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 745277006626 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 745277006627 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 745277006628 active site 745277006629 catalytic tetrad [active] 745277006630 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 745277006631 active site 745277006632 phosphate binding residues; other site 745277006633 catalytic residues [active] 745277006634 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 745277006635 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 745277006636 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 745277006637 methionine sulfoxide reductase B; Provisional; Region: PRK00222 745277006638 Protein of unknown function (DUF1315); Region: DUF1315; pfam07023 745277006639 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 745277006640 catalytic triad [active] 745277006641 metal binding site [ion binding]; metal-binding site 745277006642 conserved cis-peptide bond; other site 745277006643 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 745277006644 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 745277006645 active site 745277006646 homodimer interface [polypeptide binding]; other site 745277006647 protease 4; Provisional; Region: PRK10949 745277006648 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 745277006649 tandem repeat interface [polypeptide binding]; other site 745277006650 oligomer interface [polypeptide binding]; other site 745277006651 active site residues [active] 745277006652 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 745277006653 tandem repeat interface [polypeptide binding]; other site 745277006654 oligomer interface [polypeptide binding]; other site 745277006655 active site residues [active] 745277006656 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 745277006657 putative FMN binding site [chemical binding]; other site 745277006658 DNA topoisomerase III; Provisional; Region: PRK07726 745277006659 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 745277006660 active site 745277006661 putative interdomain interaction site [polypeptide binding]; other site 745277006662 putative metal-binding site [ion binding]; other site 745277006663 putative nucleotide binding site [chemical binding]; other site 745277006664 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 745277006665 domain I; other site 745277006666 DNA binding groove [nucleotide binding] 745277006667 phosphate binding site [ion binding]; other site 745277006668 domain II; other site 745277006669 domain III; other site 745277006670 nucleotide binding site [chemical binding]; other site 745277006671 catalytic site [active] 745277006672 domain IV; other site 745277006673 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 745277006674 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 745277006675 active site 745277006676 8-oxo-dGMP binding site [chemical binding]; other site 745277006677 nudix motif; other site 745277006678 metal binding site [ion binding]; metal-binding site 745277006679 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 745277006680 putative catalytic site [active] 745277006681 putative phosphate binding site [ion binding]; other site 745277006682 active site 745277006683 metal binding site A [ion binding]; metal-binding site 745277006684 DNA binding site [nucleotide binding] 745277006685 putative AP binding site [nucleotide binding]; other site 745277006686 putative metal binding site B [ion binding]; other site 745277006687 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 745277006688 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 745277006689 putative aromatic amino acid binding site; other site 745277006690 PAS domain; Region: PAS; smart00091 745277006691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745277006692 Walker A motif; other site 745277006693 ATP binding site [chemical binding]; other site 745277006694 Walker B motif; other site 745277006695 arginine finger; other site 745277006696 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 745277006697 dimer interface [polypeptide binding]; other site 745277006698 catalytic triad [active] 745277006699 peroxidatic and resolving cysteines [active] 745277006700 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 745277006701 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 745277006702 active site 745277006703 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 745277006704 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 745277006705 peptide binding site [polypeptide binding]; other site 745277006706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277006707 Major Facilitator Superfamily; Region: MFS_1; pfam07690 745277006708 putative substrate translocation pore; other site 745277006709 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277006710 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277006711 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 745277006712 putative effector binding pocket; other site 745277006713 dimerization interface [polypeptide binding]; other site 745277006714 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 745277006715 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 745277006716 Cl binding site [ion binding]; other site 745277006717 oligomer interface [polypeptide binding]; other site 745277006718 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 745277006719 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 745277006720 Ligand Binding Site [chemical binding]; other site 745277006721 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 745277006722 Sulfotransferase family; Region: Sulfotransfer_2; cl19526 745277006723 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 745277006724 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 745277006725 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 745277006726 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 745277006727 Na binding site [ion binding]; other site 745277006728 Alginate lyase; Region: Alginate_lyase; pfam05426 745277006729 active site 745277006730 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 745277006731 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 745277006732 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 745277006733 classical (c) SDRs; Region: SDR_c; cd05233 745277006734 NAD(P) binding site [chemical binding]; other site 745277006735 active site 745277006736 Transcriptional regulators [Transcription]; Region: FadR; COG2186 745277006737 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745277006738 DNA-binding site [nucleotide binding]; DNA binding site 745277006739 FCD domain; Region: FCD; pfam07729 745277006740 transcriptional activator RhaS; Provisional; Region: PRK13503 745277006741 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 745277006742 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 745277006743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277006744 putative substrate translocation pore; other site 745277006745 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 745277006746 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 745277006747 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745277006748 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 745277006749 substrate binding pocket [chemical binding]; other site 745277006750 membrane-bound complex binding site; other site 745277006751 hinge residues; other site 745277006752 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 745277006753 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 745277006754 Walker A/P-loop; other site 745277006755 ATP binding site [chemical binding]; other site 745277006756 Q-loop/lid; other site 745277006757 ABC transporter signature motif; other site 745277006758 Walker B; other site 745277006759 D-loop; other site 745277006760 H-loop/switch region; other site 745277006761 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 745277006762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277006763 dimer interface [polypeptide binding]; other site 745277006764 conserved gate region; other site 745277006765 putative PBP binding loops; other site 745277006766 ABC-ATPase subunit interface; other site 745277006767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277006768 dimer interface [polypeptide binding]; other site 745277006769 conserved gate region; other site 745277006770 putative PBP binding loops; other site 745277006771 ABC-ATPase subunit interface; other site 745277006772 PAS domain S-box; Region: sensory_box; TIGR00229 745277006773 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 745277006774 putative active site [active] 745277006775 heme pocket [chemical binding]; other site 745277006776 PAS domain; Region: PAS_9; pfam13426 745277006777 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745277006778 metal binding site [ion binding]; metal-binding site 745277006779 active site 745277006780 I-site; other site 745277006781 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 745277006782 Protein of unknown function (DUF3274); Region: DUF3274; pfam11678 745277006783 Transcriptional regulators [Transcription]; Region: PurR; COG1609 745277006784 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745277006785 DNA binding site [nucleotide binding] 745277006786 domain linker motif; other site 745277006787 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 745277006788 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 745277006789 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 745277006790 active site turn [active] 745277006791 phosphorylation site [posttranslational modification] 745277006792 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl19164 745277006793 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 745277006794 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 745277006795 Sugar-binding cellulase-like; Region: Cellulase-like; cl19200 745277006796 Nitrate and nitrite sensing; Region: NIT; pfam08376 745277006797 ANTAR domain; Region: ANTAR; pfam03861 745277006798 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 745277006799 NMT1-like family; Region: NMT1_2; pfam13379 745277006800 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 745277006801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277006802 dimer interface [polypeptide binding]; other site 745277006803 conserved gate region; other site 745277006804 putative PBP binding loops; other site 745277006805 ABC-ATPase subunit interface; other site 745277006806 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 745277006807 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 745277006808 Walker A/P-loop; other site 745277006809 ATP binding site [chemical binding]; other site 745277006810 Q-loop/lid; other site 745277006811 ABC transporter signature motif; other site 745277006812 Walker B; other site 745277006813 D-loop; other site 745277006814 H-loop/switch region; other site 745277006815 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 745277006816 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 745277006817 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 745277006818 nitrite reductase subunit NirD; Provisional; Region: PRK14989 745277006819 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 745277006820 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 745277006821 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 745277006822 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 745277006823 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 745277006824 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 745277006825 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 745277006826 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 745277006827 [4Fe-4S] binding site [ion binding]; other site 745277006828 molybdopterin cofactor binding site; other site 745277006829 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 745277006830 molybdopterin cofactor binding site; other site 745277006831 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 745277006832 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 745277006833 active site 745277006834 SAM binding site [chemical binding]; other site 745277006835 homodimer interface [polypeptide binding]; other site 745277006836 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 745277006837 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 745277006838 dimer interface [polypeptide binding]; other site 745277006839 PYR/PP interface [polypeptide binding]; other site 745277006840 TPP binding site [chemical binding]; other site 745277006841 substrate binding site [chemical binding]; other site 745277006842 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 745277006843 Domain of unknown function; Region: EKR; pfam10371 745277006844 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 745277006845 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 745277006846 TPP-binding site [chemical binding]; other site 745277006847 dimer interface [polypeptide binding]; other site 745277006848 Domain of unknown function (DUF333); Region: DUF333; cl19829 745277006849 META domain; Region: META; cl01245 745277006850 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 745277006851 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745277006852 Walker A/P-loop; other site 745277006853 ATP binding site [chemical binding]; other site 745277006854 Q-loop/lid; other site 745277006855 ABC transporter signature motif; other site 745277006856 Walker B; other site 745277006857 D-loop; other site 745277006858 H-loop/switch region; other site 745277006859 TOBE domain; Region: TOBE_2; pfam08402 745277006860 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 745277006861 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 745277006862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277006863 dimer interface [polypeptide binding]; other site 745277006864 conserved gate region; other site 745277006865 putative PBP binding loops; other site 745277006866 ABC-ATPase subunit interface; other site 745277006867 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 745277006868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 745277006869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277006870 dimer interface [polypeptide binding]; other site 745277006871 conserved gate region; other site 745277006872 putative PBP binding loops; other site 745277006873 ABC-ATPase subunit interface; other site 745277006874 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 745277006875 active site 745277006876 metal binding site [ion binding]; metal-binding site 745277006877 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 745277006878 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 745277006879 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 745277006880 putative ligand binding site [chemical binding]; other site 745277006881 putative NAD binding site [chemical binding]; other site 745277006882 catalytic site [active] 745277006883 hypothetical protein; Provisional; Region: PRK10695 745277006884 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 745277006885 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 745277006886 azoreductase; Reviewed; Region: PRK00170 745277006887 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 745277006888 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 745277006889 ATP binding site [chemical binding]; other site 745277006890 putative Mg++ binding site [ion binding]; other site 745277006891 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 745277006892 nucleotide binding region [chemical binding]; other site 745277006893 ATP-binding site [chemical binding]; other site 745277006894 Helicase associated domain (HA2); Region: HA2; pfam04408 745277006895 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 745277006896 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 745277006897 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 745277006898 acid shock protein precursor; Provisional; Region: PRK03577 745277006899 mannonate dehydratase; Region: uxuA; TIGR00695 745277006900 mannonate dehydratase; Provisional; Region: PRK03906 745277006901 Transcriptional regulators [Transcription]; Region: FadR; COG2186 745277006902 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745277006903 DNA-binding site [nucleotide binding]; DNA binding site 745277006904 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 745277006905 cellulose synthase regulator protein; Provisional; Region: PRK11114 745277006906 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 745277006907 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 745277006908 TPR motif; other site 745277006909 binding surface 745277006910 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 745277006911 binding surface 745277006912 TPR motif; other site 745277006913 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 745277006914 N-formylglutamate amidohydrolase; Region: FGase; cl01522 745277006915 imidazolonepropionase; Validated; Region: PRK09356 745277006916 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 745277006917 active site 745277006918 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 745277006919 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745277006920 DNA-binding site [nucleotide binding]; DNA binding site 745277006921 UTRA domain; Region: UTRA; pfam07702 745277006922 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 745277006923 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 745277006924 active site 745277006925 HutD; Region: HutD; pfam05962 745277006926 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 745277006927 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745277006928 substrate binding pocket [chemical binding]; other site 745277006929 membrane-bound complex binding site; other site 745277006930 hinge residues; other site 745277006931 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 745277006932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277006933 dimer interface [polypeptide binding]; other site 745277006934 conserved gate region; other site 745277006935 putative PBP binding loops; other site 745277006936 ABC-ATPase subunit interface; other site 745277006937 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 745277006938 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 745277006939 Walker A/P-loop; other site 745277006940 ATP binding site [chemical binding]; other site 745277006941 Q-loop/lid; other site 745277006942 ABC transporter signature motif; other site 745277006943 Walker B; other site 745277006944 D-loop; other site 745277006945 H-loop/switch region; other site 745277006946 Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221 745277006947 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 745277006948 active sites [active] 745277006949 tetramer interface [polypeptide binding]; other site 745277006950 urocanate hydratase; Provisional; Region: PRK05414 745277006951 histidinol-phosphate aminotransferase; Provisional; Region: PRK05166 745277006952 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 745277006953 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277006954 homodimer interface [polypeptide binding]; other site 745277006955 catalytic residue [active] 745277006956 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 745277006957 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 745277006958 active site 745277006959 substrate binding site [chemical binding]; other site 745277006960 FMN binding site [chemical binding]; other site 745277006961 putative catalytic residues [active] 745277006962 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 745277006963 putative active site [active] 745277006964 metal binding site [ion binding]; metal-binding site 745277006965 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 745277006966 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 745277006967 putative transposase OrfB; Reviewed; Region: PHA02517 745277006968 HTH-like domain; Region: HTH_21; pfam13276 745277006969 Integrase core domain; Region: rve; pfam00665 745277006970 Integrase core domain; Region: rve_2; pfam13333 745277006971 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 745277006972 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745277006973 NAD(P) binding site [chemical binding]; other site 745277006974 active site 745277006975 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 745277006976 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 745277006977 NAD binding site [chemical binding]; other site 745277006978 dimerization interface [polypeptide binding]; other site 745277006979 product binding site; other site 745277006980 substrate binding site [chemical binding]; other site 745277006981 zinc binding site [ion binding]; other site 745277006982 catalytic residues [active] 745277006983 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 745277006984 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 745277006985 Walker A/P-loop; other site 745277006986 ATP binding site [chemical binding]; other site 745277006987 Q-loop/lid; other site 745277006988 ABC transporter signature motif; other site 745277006989 Walker B; other site 745277006990 D-loop; other site 745277006991 H-loop/switch region; other site 745277006992 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 745277006993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277006994 dimer interface [polypeptide binding]; other site 745277006995 conserved gate region; other site 745277006996 putative PBP binding loops; other site 745277006997 ABC-ATPase subunit interface; other site 745277006998 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 745277006999 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745277007000 substrate binding pocket [chemical binding]; other site 745277007001 membrane-bound complex binding site; other site 745277007002 hinge residues; other site 745277007003 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277007004 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277007005 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 745277007006 dimerization interface [polypeptide binding]; other site 745277007007 argininosuccinate lyase; Provisional; Region: PRK00855 745277007008 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 745277007009 active sites [active] 745277007010 tetramer interface [polypeptide binding]; other site 745277007011 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 745277007012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277007013 dimer interface [polypeptide binding]; other site 745277007014 conserved gate region; other site 745277007015 putative PBP binding loops; other site 745277007016 ABC-ATPase subunit interface; other site 745277007017 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 745277007018 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 745277007019 Walker A/P-loop; other site 745277007020 ATP binding site [chemical binding]; other site 745277007021 Q-loop/lid; other site 745277007022 ABC transporter signature motif; other site 745277007023 Walker B; other site 745277007024 D-loop; other site 745277007025 H-loop/switch region; other site 745277007026 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745277007027 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 745277007028 substrate binding pocket [chemical binding]; other site 745277007029 membrane-bound complex binding site; other site 745277007030 hinge residues; other site 745277007031 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 745277007032 active site 745277007033 catalytic site [active] 745277007034 Zn binding site [ion binding]; other site 745277007035 tetramer interface [polypeptide binding]; other site 745277007036 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 745277007037 active site 745277007038 catalytic site [active] 745277007039 Zn binding site [ion binding]; other site 745277007040 tetramer interface [polypeptide binding]; other site 745277007041 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 745277007042 putative oxidoreductase; Provisional; Region: PRK11579 745277007043 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 745277007044 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 745277007045 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 745277007046 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 745277007047 active site 745277007048 purine riboside binding site [chemical binding]; other site 745277007049 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 745277007050 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 745277007051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277007052 homodimer interface [polypeptide binding]; other site 745277007053 catalytic residue [active] 745277007054 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 745277007055 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 745277007056 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 745277007057 active site turn [active] 745277007058 phosphorylation site [posttranslational modification] 745277007059 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 745277007060 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745277007061 DNA binding site [nucleotide binding] 745277007062 domain linker motif; other site 745277007063 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 745277007064 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 745277007065 Protein of unknown function (DUF1283); Region: DUF1283; cl11644 745277007066 hypothetical protein; Provisional; Region: PRK02237 745277007067 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277007068 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277007069 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 745277007070 dimerization interface [polypeptide binding]; other site 745277007071 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 745277007072 Sulfate transporter family; Region: Sulfate_transp; cl19250 745277007073 malonic semialdehyde reductase; Provisional; Region: PRK10538 745277007074 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 745277007075 putative NAD(P) binding site [chemical binding]; other site 745277007076 homodimer interface [polypeptide binding]; other site 745277007077 homotetramer interface [polypeptide binding]; other site 745277007078 active site 745277007079 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 745277007080 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 745277007081 active site 745277007082 catalytic tetrad [active] 745277007083 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 745277007084 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 745277007085 Walker A/P-loop; other site 745277007086 ATP binding site [chemical binding]; other site 745277007087 Q-loop/lid; other site 745277007088 ABC transporter signature motif; other site 745277007089 Walker B; other site 745277007090 D-loop; other site 745277007091 H-loop/switch region; other site 745277007092 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 745277007093 substrate binding site [chemical binding]; other site 745277007094 ATP binding site [chemical binding]; other site 745277007095 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 745277007096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277007097 dimer interface [polypeptide binding]; other site 745277007098 conserved gate region; other site 745277007099 putative PBP binding loops; other site 745277007100 ABC-ATPase subunit interface; other site 745277007101 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 745277007102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277007103 dimer interface [polypeptide binding]; other site 745277007104 conserved gate region; other site 745277007105 putative PBP binding loops; other site 745277007106 ABC-ATPase subunit interface; other site 745277007107 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 745277007108 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 745277007109 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 745277007110 non-specific DNA interactions [nucleotide binding]; other site 745277007111 DNA binding site [nucleotide binding] 745277007112 sequence specific DNA binding site [nucleotide binding]; other site 745277007113 putative cAMP binding site [chemical binding]; other site 745277007114 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 745277007115 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 745277007116 nucleotide binding site [chemical binding]; other site 745277007117 Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; cl04145 745277007118 guanine deaminase; Provisional; Region: PRK09228 745277007119 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 745277007120 active site 745277007121 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 745277007122 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745277007123 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 745277007124 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 745277007125 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 745277007126 catalytic loop [active] 745277007127 iron binding site [ion binding]; other site 745277007128 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 745277007129 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 745277007130 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 745277007131 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 745277007132 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 745277007133 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 745277007134 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 745277007135 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 745277007136 XdhC Rossmann domain; Region: XdhC_C; pfam13478 745277007137 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 745277007138 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745277007139 Walker A/P-loop; other site 745277007140 ATP binding site [chemical binding]; other site 745277007141 Q-loop/lid; other site 745277007142 ABC transporter signature motif; other site 745277007143 Walker B; other site 745277007144 D-loop; other site 745277007145 H-loop/switch region; other site 745277007146 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 745277007147 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 745277007148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277007149 dimer interface [polypeptide binding]; other site 745277007150 conserved gate region; other site 745277007151 putative PBP binding loops; other site 745277007152 ABC-ATPase subunit interface; other site 745277007153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277007154 dimer interface [polypeptide binding]; other site 745277007155 conserved gate region; other site 745277007156 putative PBP binding loops; other site 745277007157 ABC-ATPase subunit interface; other site 745277007158 Transcriptional regulators [Transcription]; Region: GntR; COG1802 745277007159 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 745277007160 DNA-binding site [nucleotide binding]; DNA binding site 745277007161 FCD domain; Region: FCD; pfam07729 745277007162 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 745277007163 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 745277007164 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745277007165 Walker A/P-loop; other site 745277007166 ATP binding site [chemical binding]; other site 745277007167 Q-loop/lid; other site 745277007168 ABC transporter signature motif; other site 745277007169 Walker B; other site 745277007170 D-loop; other site 745277007171 H-loop/switch region; other site 745277007172 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 745277007173 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 745277007174 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 745277007175 fumarate hydratase; Reviewed; Region: fumC; PRK00485 745277007176 Class II fumarases; Region: Fumarase_classII; cd01362 745277007177 active site 745277007178 tetramer interface [polypeptide binding]; other site 745277007179 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 745277007180 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 745277007181 Fic family protein [Function unknown]; Region: COG3177 745277007182 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 745277007183 Fic/DOC family; Region: Fic; pfam02661 745277007184 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 745277007185 putative Zn2+ binding site [ion binding]; other site 745277007186 putative DNA binding site [nucleotide binding]; other site 745277007187 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 745277007188 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 745277007189 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 745277007190 active site 745277007191 metal binding site [ion binding]; metal-binding site 745277007192 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 745277007193 N-acetyl-D-glucosamine binding site [chemical binding]; other site 745277007194 catalytic residue [active] 745277007195 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 745277007196 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 745277007197 conserved cys residue [active] 745277007198 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277007199 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 745277007200 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 745277007201 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 745277007202 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 745277007203 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 745277007204 Transcriptional regulators [Transcription]; Region: MarR; COG1846 745277007205 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 745277007206 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 745277007207 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 745277007208 YebF-like protein; Region: YebF; cl10126 745277007209 hypothetical protein; Provisional; Region: PRK10515 745277007210 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 745277007211 active site residue [active] 745277007212 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 745277007213 active site residue [active] 745277007214 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 745277007215 active site residue [active] 745277007216 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 745277007217 active site residue [active] 745277007218 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 745277007219 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277007220 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277007221 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 745277007222 dimerization interface [polypeptide binding]; other site 745277007223 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 745277007224 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 745277007225 dimer interface [polypeptide binding]; other site 745277007226 active site 745277007227 non-prolyl cis peptide bond; other site 745277007228 insertion regions; other site 745277007229 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745277007230 substrate binding pocket [chemical binding]; other site 745277007231 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 745277007232 membrane-bound complex binding site; other site 745277007233 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 745277007234 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 745277007235 conserved cys residue [active] 745277007236 Pirin; Region: Pirin; pfam02678 745277007237 Pirin-related protein [General function prediction only]; Region: COG1741 745277007238 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 745277007239 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 745277007240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277007241 putative substrate translocation pore; other site 745277007242 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 745277007243 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 745277007244 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 745277007245 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 745277007246 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 745277007247 putative molybdopterin cofactor binding site [chemical binding]; other site 745277007248 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 745277007249 putative molybdopterin cofactor binding site; other site 745277007250 exoribonuclease II; Provisional; Region: PRK05054 745277007251 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 745277007252 RNB domain; Region: RNB; pfam00773 745277007253 S1 RNA binding domain; Region: S1; pfam00575 745277007254 RNA binding site [nucleotide binding]; other site 745277007255 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 745277007256 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277007257 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 745277007258 substrate binding site [chemical binding]; other site 745277007259 dimerization interface [polypeptide binding]; other site 745277007260 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 745277007261 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 745277007262 putative ligand binding site [chemical binding]; other site 745277007263 NAD binding site [chemical binding]; other site 745277007264 catalytic site [active] 745277007265 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 745277007266 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 745277007267 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 745277007268 active site 745277007269 catalytic site [active] 745277007270 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 745277007271 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 745277007272 Smr domain; Region: Smr; pfam01713 745277007273 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192 745277007274 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745277007275 active site 745277007276 motif I; other site 745277007277 motif II; other site 745277007278 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 745277007279 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 745277007280 Integral membrane protein TerC family; Region: TerC; cl10468 745277007281 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 745277007282 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 745277007283 ligand binding site [chemical binding]; other site 745277007284 flexible hinge region; other site 745277007285 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 745277007286 putative switch regulator; other site 745277007287 non-specific DNA interactions [nucleotide binding]; other site 745277007288 DNA binding site [nucleotide binding] 745277007289 sequence specific DNA binding site [nucleotide binding]; other site 745277007290 putative cAMP binding site [chemical binding]; other site 745277007291 universal stress protein UspE; Provisional; Region: PRK11175 745277007292 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 745277007293 Ligand Binding Site [chemical binding]; other site 745277007294 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 745277007295 Ligand Binding Site [chemical binding]; other site 745277007296 Transposase IS200 like; Region: Y1_Tnp; pfam01797 745277007297 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 745277007298 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 745277007299 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 745277007300 ligand binding site [chemical binding]; other site 745277007301 homodimer interface [polypeptide binding]; other site 745277007302 NAD(P) binding site [chemical binding]; other site 745277007303 trimer interface B [polypeptide binding]; other site 745277007304 trimer interface A [polypeptide binding]; other site 745277007305 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 745277007306 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 745277007307 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 745277007308 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 745277007309 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 745277007310 active site 745277007311 dimer interface [polypeptide binding]; other site 745277007312 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 745277007313 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 745277007314 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 745277007315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277007316 dimer interface [polypeptide binding]; other site 745277007317 conserved gate region; other site 745277007318 putative PBP binding loops; other site 745277007319 ABC-ATPase subunit interface; other site 745277007320 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 745277007321 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 745277007322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277007323 dimer interface [polypeptide binding]; other site 745277007324 conserved gate region; other site 745277007325 putative PBP binding loops; other site 745277007326 ABC-ATPase subunit interface; other site 745277007327 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 745277007328 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277007329 Walker A/P-loop; other site 745277007330 ATP binding site [chemical binding]; other site 745277007331 Q-loop/lid; other site 745277007332 ABC transporter signature motif; other site 745277007333 Walker B; other site 745277007334 D-loop; other site 745277007335 H-loop/switch region; other site 745277007336 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745277007337 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277007338 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 745277007339 Walker A/P-loop; other site 745277007340 ATP binding site [chemical binding]; other site 745277007341 Q-loop/lid; other site 745277007342 ABC transporter signature motif; other site 745277007343 Walker B; other site 745277007344 D-loop; other site 745277007345 H-loop/switch region; other site 745277007346 Beta-lactamase; Region: Beta-lactamase; pfam00144 745277007347 putative transporter; Provisional; Region: PRK11660 745277007348 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 745277007349 Sulfate transporter family; Region: Sulfate_transp; cl19250 745277007350 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 745277007351 DAHP synthetase I family; Region: DAHP_synth_1; cl17225 745277007352 hypothetical protein; Provisional; Region: PRK10941 745277007353 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 745277007354 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 745277007355 binding surface 745277007356 TPR motif; other site 745277007357 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 745277007358 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 745277007359 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277007360 S-adenosylmethionine binding site [chemical binding]; other site 745277007361 peptide chain release factor 1; Validated; Region: prfA; PRK00591 745277007362 This domain is found in peptide chain release factors; Region: PCRF; smart00937 745277007363 RF-1 domain; Region: RF-1; pfam00472 745277007364 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 745277007365 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 745277007366 tRNA; other site 745277007367 putative tRNA binding site [nucleotide binding]; other site 745277007368 putative NADP binding site [chemical binding]; other site 745277007369 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 745277007370 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 745277007371 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 745277007372 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 745277007373 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 745277007374 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 745277007375 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 745277007376 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 745277007377 active site 745277007378 hypothetical protein; Provisional; Region: PRK10692 745277007379 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 745277007380 putative active site [active] 745277007381 catalytic residue [active] 745277007382 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 745277007383 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 745277007384 Soluble P-type ATPase [General function prediction only]; Region: COG4087 745277007385 High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflK; cd03404 745277007386 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 745277007387 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 745277007388 High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflC; cd03405 745277007389 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 745277007390 High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflK; cd03404 745277007391 HflK protein; Region: hflK; TIGR01933 745277007392 Transposase IS200 like; Region: Y1_Tnp; pfam01797 745277007393 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 745277007394 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 745277007395 Sulfate transporter family; Region: Sulfate_transp; pfam00916 745277007396 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 745277007397 GTP-binding protein YchF; Reviewed; Region: PRK09601 745277007398 YchF GTPase; Region: YchF; cd01900 745277007399 G1 box; other site 745277007400 GTP/Mg2+ binding site [chemical binding]; other site 745277007401 Switch I region; other site 745277007402 G2 box; other site 745277007403 Switch II region; other site 745277007404 G3 box; other site 745277007405 G4 box; other site 745277007406 G5 box; other site 745277007407 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 745277007408 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 745277007409 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 745277007410 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 745277007411 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 745277007412 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 745277007413 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 745277007414 PapC N-terminal domain; Region: PapC_N; pfam13954 745277007415 Outer membrane usher protein; Region: Usher; pfam00577 745277007416 PapC C-terminal domain; Region: PapC_C; pfam13953 745277007417 putative major fimbrial protein SthE; Provisional; Region: PRK15292 745277007418 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 745277007419 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 745277007420 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 745277007421 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 745277007422 active site 745277007423 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 745277007424 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 745277007425 N-terminal plug; other site 745277007426 ligand-binding site [chemical binding]; other site 745277007427 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 745277007428 HAMP domain; Region: HAMP; pfam00672 745277007429 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745277007430 dimer interface [polypeptide binding]; other site 745277007431 phosphorylation site [posttranslational modification] 745277007432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277007433 ATP binding site [chemical binding]; other site 745277007434 Mg2+ binding site [ion binding]; other site 745277007435 G-X-G motif; other site 745277007436 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 745277007437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277007438 active site 745277007439 phosphorylation site [posttranslational modification] 745277007440 intermolecular recognition site; other site 745277007441 dimerization interface [polypeptide binding]; other site 745277007442 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 745277007443 DNA binding site [nucleotide binding] 745277007444 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 745277007445 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 745277007446 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 745277007447 Putative glucoamylase; Region: Glycoamylase; pfam10091 745277007448 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 745277007449 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 745277007450 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 745277007451 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 745277007452 FMN binding site [chemical binding]; other site 745277007453 dimer interface [polypeptide binding]; other site 745277007454 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745277007455 metal binding site [ion binding]; metal-binding site 745277007456 active site 745277007457 I-site; other site 745277007458 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 745277007459 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 745277007460 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 745277007461 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 745277007462 putative active site [active] 745277007463 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745277007464 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 745277007465 substrate binding pocket [chemical binding]; other site 745277007466 membrane-bound complex binding site; other site 745277007467 hinge residues; other site 745277007468 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 745277007469 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 745277007470 ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Region: ectoine_ehuD; TIGR03003 745277007471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277007472 dimer interface [polypeptide binding]; other site 745277007473 conserved gate region; other site 745277007474 putative PBP binding loops; other site 745277007475 ABC-ATPase subunit interface; other site 745277007476 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 745277007477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277007478 dimer interface [polypeptide binding]; other site 745277007479 conserved gate region; other site 745277007480 putative PBP binding loops; other site 745277007481 ABC-ATPase subunit interface; other site 745277007482 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 745277007483 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 745277007484 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 745277007485 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277007486 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277007487 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 745277007488 dimerization interface [polypeptide binding]; other site 745277007489 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 745277007490 putative active site [active] 745277007491 putative FMN binding site [chemical binding]; other site 745277007492 putative substrate binding site [chemical binding]; other site 745277007493 putative catalytic residue [active] 745277007494 FMN-binding domain; Region: FMN_bind; cl01081 745277007495 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 745277007496 L-aspartate oxidase; Provisional; Region: PRK06175 745277007497 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 745277007498 anion transporter; Region: dass; TIGR00785 745277007499 transmembrane helices; other site 745277007500 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 745277007501 DNA-binding site [nucleotide binding]; DNA binding site 745277007502 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 745277007503 FCD domain; Region: FCD; pfam07729 745277007504 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 745277007505 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 745277007506 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 745277007507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277007508 dimer interface [polypeptide binding]; other site 745277007509 conserved gate region; other site 745277007510 putative PBP binding loops; other site 745277007511 ABC-ATPase subunit interface; other site 745277007512 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 745277007513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277007514 dimer interface [polypeptide binding]; other site 745277007515 conserved gate region; other site 745277007516 putative PBP binding loops; other site 745277007517 ABC-ATPase subunit interface; other site 745277007518 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 745277007519 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 745277007520 metal binding site [ion binding]; metal-binding site 745277007521 D-cysteine desulfhydrase; Validated; Region: PRK03910 745277007522 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 745277007523 catalytic residue [active] 745277007524 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 745277007525 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124 745277007526 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 745277007527 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 745277007528 active site residue [active] 745277007529 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 745277007530 active site residue [active] 745277007531 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 745277007532 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277007533 Walker A/P-loop; other site 745277007534 ATP binding site [chemical binding]; other site 745277007535 Q-loop/lid; other site 745277007536 ABC transporter signature motif; other site 745277007537 Walker B; other site 745277007538 D-loop; other site 745277007539 H-loop/switch region; other site 745277007540 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745277007541 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277007542 Walker A/P-loop; other site 745277007543 ATP binding site [chemical binding]; other site 745277007544 Q-loop/lid; other site 745277007545 ABC transporter signature motif; other site 745277007546 Walker B; other site 745277007547 D-loop; other site 745277007548 H-loop/switch region; other site 745277007549 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745277007550 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 745277007551 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 745277007552 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277007553 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277007554 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 745277007555 TM-ABC transporter signature motif; other site 745277007556 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 745277007557 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 745277007558 Walker A/P-loop; other site 745277007559 ATP binding site [chemical binding]; other site 745277007560 Q-loop/lid; other site 745277007561 ABC transporter signature motif; other site 745277007562 Walker B; other site 745277007563 D-loop; other site 745277007564 H-loop/switch region; other site 745277007565 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 745277007566 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 745277007567 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 745277007568 ligand binding site [chemical binding]; other site 745277007569 ribulokinase; Provisional; Region: PRK04123 745277007570 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 745277007571 N- and C-terminal domain interface [polypeptide binding]; other site 745277007572 active site 745277007573 MgATP binding site [chemical binding]; other site 745277007574 catalytic site [active] 745277007575 metal binding site [ion binding]; metal-binding site 745277007576 carbohydrate binding site [chemical binding]; other site 745277007577 homodimer interface [polypeptide binding]; other site 745277007578 L-arabinose isomerase; Provisional; Region: PRK02929 745277007579 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 745277007580 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 745277007581 trimer interface [polypeptide binding]; other site 745277007582 putative substrate binding site [chemical binding]; other site 745277007583 putative metal binding site [ion binding]; other site 745277007584 Transposase; Region: DEDD_Tnp_IS110; pfam01548 745277007585 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 745277007586 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 745277007587 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 745277007588 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 745277007589 Walker A/P-loop; other site 745277007590 ATP binding site [chemical binding]; other site 745277007591 Q-loop/lid; other site 745277007592 ABC transporter signature motif; other site 745277007593 Walker B; other site 745277007594 D-loop; other site 745277007595 H-loop/switch region; other site 745277007596 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 745277007597 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 745277007598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277007599 dimer interface [polypeptide binding]; other site 745277007600 conserved gate region; other site 745277007601 putative PBP binding loops; other site 745277007602 ABC-ATPase subunit interface; other site 745277007603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277007604 dimer interface [polypeptide binding]; other site 745277007605 conserved gate region; other site 745277007606 putative PBP binding loops; other site 745277007607 ABC-ATPase subunit interface; other site 745277007608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277007609 Major Facilitator Superfamily; Region: MFS_1; pfam07690 745277007610 putative substrate translocation pore; other site 745277007611 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 745277007612 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 745277007613 AAA domain; Region: AAA_26; pfam13500 745277007614 MarR family; Region: MarR_2; cl17246 745277007615 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 745277007616 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 745277007617 nucleotide binding site [chemical binding]; other site 745277007618 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 745277007619 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 745277007620 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277007621 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 745277007622 dimerization interface [polypeptide binding]; other site 745277007623 substrate binding pocket [chemical binding]; other site 745277007624 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 745277007625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277007626 putative substrate translocation pore; other site 745277007627 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 745277007628 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 745277007629 Walker A/P-loop; other site 745277007630 ATP binding site [chemical binding]; other site 745277007631 Q-loop/lid; other site 745277007632 ABC transporter signature motif; other site 745277007633 Walker B; other site 745277007634 D-loop; other site 745277007635 H-loop/switch region; other site 745277007636 TOBE domain; Region: TOBE_2; pfam08402 745277007637 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 745277007638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277007639 dimer interface [polypeptide binding]; other site 745277007640 conserved gate region; other site 745277007641 putative PBP binding loops; other site 745277007642 ABC-ATPase subunit interface; other site 745277007643 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 745277007644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277007645 dimer interface [polypeptide binding]; other site 745277007646 conserved gate region; other site 745277007647 putative PBP binding loops; other site 745277007648 ABC-ATPase subunit interface; other site 745277007649 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 745277007650 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 745277007651 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 745277007652 homodimer interface [polypeptide binding]; other site 745277007653 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 745277007654 substrate-cofactor binding pocket; other site 745277007655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277007656 catalytic residue [active] 745277007657 Transcriptional regulators [Transcription]; Region: FadR; COG2186 745277007658 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745277007659 DNA-binding site [nucleotide binding]; DNA binding site 745277007660 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 745277007661 hypothetical protein; Provisional; Region: PRK06185 745277007662 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 745277007663 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 745277007664 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 745277007665 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 745277007666 electron transport complex protein RsxA; Provisional; Region: PRK05151 745277007667 electron transport complex protein RnfB; Provisional; Region: PRK05113 745277007668 Putative Fe-S cluster; Region: FeS; cl17515 745277007669 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 745277007670 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 745277007671 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 745277007672 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 745277007673 SLBB domain; Region: SLBB; pfam10531 745277007674 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 745277007675 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 745277007676 electron transport complex protein RnfG; Validated; Region: PRK01908 745277007677 electron transport complex RsxE subunit; Provisional; Region: PRK12405 745277007678 endonuclease III; Provisional; Region: PRK10702 745277007679 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 745277007680 minor groove reading motif; other site 745277007681 helix-hairpin-helix signature motif; other site 745277007682 substrate binding pocket [chemical binding]; other site 745277007683 active site 745277007684 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 745277007685 hypothetical protein; Provisional; Region: PRK11667 745277007686 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277007687 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277007688 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 745277007689 dimerization interface [polypeptide binding]; other site 745277007690 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 745277007691 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 745277007692 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 745277007693 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 745277007694 putative metal binding site [ion binding]; other site 745277007695 putative homodimer interface [polypeptide binding]; other site 745277007696 putative homotetramer interface [polypeptide binding]; other site 745277007697 putative homodimer-homodimer interface [polypeptide binding]; other site 745277007698 putative allosteric switch controlling residues; other site 745277007699 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 745277007700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277007701 putative substrate translocation pore; other site 745277007702 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 745277007703 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 745277007704 HAMP domain; Region: HAMP; pfam00672 745277007705 Histidine kinase; Region: HisKA_3; pfam07730 745277007706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277007707 ATP binding site [chemical binding]; other site 745277007708 Mg2+ binding site [ion binding]; other site 745277007709 G-X-G motif; other site 745277007710 transcriptional regulator NarL; Provisional; Region: PRK10651 745277007711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277007712 active site 745277007713 phosphorylation site [posttranslational modification] 745277007714 intermolecular recognition site; other site 745277007715 dimerization interface [polypeptide binding]; other site 745277007716 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 745277007717 DNA binding residues [nucleotide binding] 745277007718 dimerization interface [polypeptide binding]; other site 745277007719 putative invasin; Provisional; Region: PRK10177 745277007720 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 745277007721 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 745277007722 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 745277007723 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 745277007724 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 745277007725 Cytochrome c; Region: Cytochrom_C; pfam00034 745277007726 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 745277007727 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 745277007728 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 745277007729 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 745277007730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277007731 active site 745277007732 phosphorylation site [posttranslational modification] 745277007733 intermolecular recognition site; other site 745277007734 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 745277007735 DNA binding site [nucleotide binding] 745277007736 sensor protein RstB; Provisional; Region: PRK10604 745277007737 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 745277007738 dimerization interface [polypeptide binding]; other site 745277007739 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745277007740 dimer interface [polypeptide binding]; other site 745277007741 phosphorylation site [posttranslational modification] 745277007742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277007743 ATP binding site [chemical binding]; other site 745277007744 Mg2+ binding site [ion binding]; other site 745277007745 G-X-G motif; other site 745277007746 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 745277007747 active site 745277007748 Zn binding site [ion binding]; other site 745277007749 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 745277007750 inhibitor site; inhibition site 745277007751 active site 745277007752 dimer interface [polypeptide binding]; other site 745277007753 catalytic residue [active] 745277007754 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 745277007755 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 745277007756 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 745277007757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277007758 metabolite-proton symporter; Region: 2A0106; TIGR00883 745277007759 putative substrate translocation pore; other site 745277007760 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 745277007761 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 745277007762 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 745277007763 putative active site [active] 745277007764 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 745277007765 active site 745277007766 NAD binding site [chemical binding]; other site 745277007767 metal binding site [ion binding]; metal-binding site 745277007768 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 745277007769 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 745277007770 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 745277007771 active site 745277007772 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 745277007773 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 745277007774 metal binding site [ion binding]; metal-binding site 745277007775 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 745277007776 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277007777 Walker A/P-loop; other site 745277007778 ATP binding site [chemical binding]; other site 745277007779 Q-loop/lid; other site 745277007780 ABC transporter signature motif; other site 745277007781 Walker B; other site 745277007782 D-loop; other site 745277007783 H-loop/switch region; other site 745277007784 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745277007785 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277007786 Walker A/P-loop; other site 745277007787 ATP binding site [chemical binding]; other site 745277007788 Q-loop/lid; other site 745277007789 ABC transporter signature motif; other site 745277007790 Walker B; other site 745277007791 D-loop; other site 745277007792 H-loop/switch region; other site 745277007793 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 745277007794 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 745277007795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277007796 dimer interface [polypeptide binding]; other site 745277007797 conserved gate region; other site 745277007798 putative PBP binding loops; other site 745277007799 ABC-ATPase subunit interface; other site 745277007800 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 745277007801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277007802 dimer interface [polypeptide binding]; other site 745277007803 conserved gate region; other site 745277007804 putative PBP binding loops; other site 745277007805 ABC-ATPase subunit interface; other site 745277007806 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 745277007807 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 745277007808 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 745277007809 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 745277007810 metal binding site [ion binding]; metal-binding site 745277007811 dimer interface [polypeptide binding]; other site 745277007812 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 745277007813 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745277007814 DNA-binding site [nucleotide binding]; DNA binding site 745277007815 UTRA domain; Region: UTRA; cl17743 745277007816 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277007817 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277007818 LysR substrate binding domain; Region: LysR_substrate; pfam03466 745277007819 dimerization interface [polypeptide binding]; other site 745277007820 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 745277007821 SxDxEG motif; other site 745277007822 active site 745277007823 metal binding site [ion binding]; metal-binding site 745277007824 homopentamer interface [polypeptide binding]; other site 745277007825 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 745277007826 homodimer interface [polypeptide binding]; other site 745277007827 homotetramer interface [polypeptide binding]; other site 745277007828 active site pocket [active] 745277007829 cleavage site 745277007830 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 745277007831 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 745277007832 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277007833 dimer interface [polypeptide binding]; other site 745277007834 conserved gate region; other site 745277007835 putative PBP binding loops; other site 745277007836 ABC-ATPase subunit interface; other site 745277007837 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 745277007838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277007839 dimer interface [polypeptide binding]; other site 745277007840 conserved gate region; other site 745277007841 putative PBP binding loops; other site 745277007842 ABC-ATPase subunit interface; other site 745277007843 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 745277007844 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 745277007845 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 745277007846 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277007847 Walker A/P-loop; other site 745277007848 ATP binding site [chemical binding]; other site 745277007849 Q-loop/lid; other site 745277007850 ABC transporter signature motif; other site 745277007851 Walker B; other site 745277007852 D-loop; other site 745277007853 H-loop/switch region; other site 745277007854 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745277007855 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277007856 Walker A/P-loop; other site 745277007857 ATP binding site [chemical binding]; other site 745277007858 Q-loop/lid; other site 745277007859 ABC transporter signature motif; other site 745277007860 Walker B; other site 745277007861 D-loop; other site 745277007862 H-loop/switch region; other site 745277007863 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 745277007864 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 745277007865 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 745277007866 active site 745277007867 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 745277007868 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 745277007869 trimer interface [polypeptide binding]; other site 745277007870 eyelet of channel; other site 745277007871 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 745277007872 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 745277007873 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745277007874 Walker A/P-loop; other site 745277007875 ATP binding site [chemical binding]; other site 745277007876 Q-loop/lid; other site 745277007877 ABC transporter signature motif; other site 745277007878 Walker B; other site 745277007879 D-loop; other site 745277007880 H-loop/switch region; other site 745277007881 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 745277007882 homodimer interface [polypeptide binding]; other site 745277007883 substrate-cofactor binding pocket; other site 745277007884 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277007885 catalytic residue [active] 745277007886 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 745277007887 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 745277007888 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 745277007889 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 745277007890 Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711 745277007891 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 745277007892 Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710 745277007893 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 745277007894 [4Fe-4S] binding site [ion binding]; other site 745277007895 molybdopterin cofactor binding site [chemical binding]; other site 745277007896 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 745277007897 molybdopterin cofactor binding site; other site 745277007898 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 745277007899 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 745277007900 Cl binding site [ion binding]; other site 745277007901 oligomer interface [polypeptide binding]; other site 745277007902 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 745277007903 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 745277007904 Cl- selectivity filter; other site 745277007905 Cl- binding residues [ion binding]; other site 745277007906 pore gating glutamate residue; other site 745277007907 dimer interface [polypeptide binding]; other site 745277007908 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 745277007909 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 745277007910 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 745277007911 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 745277007912 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277007913 Walker A/P-loop; other site 745277007914 ATP binding site [chemical binding]; other site 745277007915 Q-loop/lid; other site 745277007916 ABC transporter signature motif; other site 745277007917 Walker B; other site 745277007918 D-loop; other site 745277007919 H-loop/switch region; other site 745277007920 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 745277007921 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277007922 Walker A/P-loop; other site 745277007923 ATP binding site [chemical binding]; other site 745277007924 Q-loop/lid; other site 745277007925 ABC transporter signature motif; other site 745277007926 Walker B; other site 745277007927 D-loop; other site 745277007928 H-loop/switch region; other site 745277007929 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 745277007930 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 745277007931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277007932 dimer interface [polypeptide binding]; other site 745277007933 conserved gate region; other site 745277007934 putative PBP binding loops; other site 745277007935 ABC-ATPase subunit interface; other site 745277007936 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 745277007937 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277007938 dimer interface [polypeptide binding]; other site 745277007939 conserved gate region; other site 745277007940 putative PBP binding loops; other site 745277007941 ABC-ATPase subunit interface; other site 745277007942 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 745277007943 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 745277007944 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 745277007945 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 745277007946 putative active site pocket [active] 745277007947 dimerization interface [polypeptide binding]; other site 745277007948 putative catalytic residue [active] 745277007949 cation transport regulator; Reviewed; Region: chaB; PRK09582 745277007950 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 745277007951 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 745277007952 hypothetical protein; Provisional; Region: PRK10536 745277007953 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 745277007954 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 745277007955 Uncharacterized subfamiy of Cupredoxin; Region: Cupredoxin_like_3; cd04203 745277007956 Type 1 (T1) Cu binding site [ion binding]; other site 745277007957 Imelysin; Region: Peptidase_M75; pfam09375 745277007958 Iron permease FTR1 family; Region: FTR1; cl00475 745277007959 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 745277007960 Na binding site [ion binding]; other site 745277007961 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 745277007962 Predicted transcriptional regulator [Transcription]; Region: COG3905 745277007963 DNA-binding domain of Proline dehydrogenase; Region: Pro_dh-DNA_bdg; pfam14850 745277007964 Proline dehydrogenase; Region: Pro_dh; pfam01619 745277007965 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 745277007966 Glutamate binding site [chemical binding]; other site 745277007967 NAD binding site [chemical binding]; other site 745277007968 catalytic residues [active] 745277007969 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 745277007970 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 745277007971 Walker A/P-loop; other site 745277007972 ATP binding site [chemical binding]; other site 745277007973 Q-loop/lid; other site 745277007974 ABC transporter signature motif; other site 745277007975 Walker B; other site 745277007976 D-loop; other site 745277007977 H-loop/switch region; other site 745277007978 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745277007979 amino acid ABC transporter permease; Provisional; Region: PRK15100 745277007980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277007981 dimer interface [polypeptide binding]; other site 745277007982 conserved gate region; other site 745277007983 putative PBP binding loops; other site 745277007984 ABC-ATPase subunit interface; other site 745277007985 cystine transporter subunit; Provisional; Region: PRK11260 745277007986 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745277007987 substrate binding pocket [chemical binding]; other site 745277007988 membrane-bound complex binding site; other site 745277007989 hinge residues; other site 745277007990 D-cysteine desulfhydrase; Validated; Region: PRK03910 745277007991 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 745277007992 catalytic residue [active] 745277007993 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 745277007994 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 745277007995 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 745277007996 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 745277007997 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 745277007998 DNA binding residues [nucleotide binding] 745277007999 flagellin; Validated; Region: PRK06819 745277008000 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 745277008001 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 745277008002 flagellar capping protein; Reviewed; Region: fliD; PRK08032 745277008003 Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465 745277008004 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 745277008005 flagellar protein FliS; Validated; Region: fliS; PRK05685 745277008006 Flagellar protein FliT; Region: FliT; cl05125 745277008007 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 745277008008 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277008009 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 745277008010 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 745277008011 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 745277008012 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745277008013 Coenzyme A binding pocket [chemical binding]; other site 745277008014 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 745277008015 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 745277008016 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 745277008017 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 745277008018 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 745277008019 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 745277008020 FliG N-terminal domain; Region: FliG_N; pfam14842 745277008021 FliG middle domain; Region: FliG_M; pfam14841 745277008022 FliG C-terminal domain; Region: FliG_C; pfam01706 745277008023 flagellar assembly protein H; Validated; Region: fliH; PRK05687 745277008024 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 745277008025 Flagellar assembly protein FliH; Region: FliH; pfam02108 745277008026 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 745277008027 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 745277008028 Walker A motif/ATP binding site; other site 745277008029 Walker B motif; other site 745277008030 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 745277008031 flagellar hook-length control protein; Provisional; Region: PRK10118 745277008032 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 745277008033 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 745277008034 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 745277008035 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 745277008036 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 745277008037 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 745277008038 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 745277008039 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 745277008040 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 745277008041 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 745277008042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277008043 S-adenosylmethionine binding site [chemical binding]; other site 745277008044 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 745277008045 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 745277008046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277008047 dimer interface [polypeptide binding]; other site 745277008048 conserved gate region; other site 745277008049 putative PBP binding loops; other site 745277008050 ABC-ATPase subunit interface; other site 745277008051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277008052 dimer interface [polypeptide binding]; other site 745277008053 conserved gate region; other site 745277008054 putative PBP binding loops; other site 745277008055 ABC-ATPase subunit interface; other site 745277008056 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 745277008057 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745277008058 Walker A/P-loop; other site 745277008059 ATP binding site [chemical binding]; other site 745277008060 Q-loop/lid; other site 745277008061 ABC transporter signature motif; other site 745277008062 Walker B; other site 745277008063 D-loop; other site 745277008064 H-loop/switch region; other site 745277008065 TOBE domain; Region: TOBE_2; pfam08402 745277008066 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 745277008067 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 745277008068 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 745277008069 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 745277008070 RimK-like ATP-grasp domain; Region: RimK; pfam08443 745277008071 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 745277008072 dimer interface [polypeptide binding]; other site 745277008073 FMN binding site [chemical binding]; other site 745277008074 NADPH bind site [chemical binding]; other site 745277008075 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 745277008076 GSH binding site [chemical binding]; other site 745277008077 catalytic residues [active] 745277008078 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 745277008079 putative transporter; Provisional; Region: PRK04972 745277008080 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 745277008081 TrkA-C domain; Region: TrkA_C; pfam02080 745277008082 TrkA-C domain; Region: TrkA_C; pfam02080 745277008083 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 745277008084 BLMT, a bleomycin resistance protein encoded on the transposon Tn5, and similar proteins; Region: BLMT_like; cd08350 745277008085 dimer interface [polypeptide binding]; other site 745277008086 ligand binding site [chemical binding]; other site 745277008087 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 745277008088 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745277008089 Coenzyme A binding pocket [chemical binding]; other site 745277008090 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 745277008091 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 745277008092 active site 745277008093 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 745277008094 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 745277008095 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 745277008096 GlpM protein; Region: GlpM; pfam06942 745277008097 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277008098 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277008099 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 745277008100 dimerization interface [polypeptide binding]; other site 745277008101 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 745277008102 hypothetical protein; Provisional; Region: PRK08201 745277008103 metal binding site [ion binding]; metal-binding site 745277008104 putative dimer interface [polypeptide binding]; other site 745277008105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277008106 metabolite-proton symporter; Region: 2A0106; TIGR00883 745277008107 putative substrate translocation pore; other site 745277008108 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 745277008109 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 745277008110 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 745277008111 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 745277008112 putative ligand binding site [chemical binding]; other site 745277008113 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 745277008114 putative symporter YagG; Provisional; Region: PRK09669; cl15392 745277008115 putative alpha-glucosidase; Provisional; Region: PRK10658 745277008116 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 745277008117 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 745277008118 active site 745277008119 homotrimer interface [polypeptide binding]; other site 745277008120 catalytic site [active] 745277008121 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 745277008122 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 745277008123 putative dimerization interface [polypeptide binding]; other site 745277008124 Transcriptional regulators [Transcription]; Region: PurR; COG1609 745277008125 putative ligand binding site [chemical binding]; other site 745277008126 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277008127 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 745277008128 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277008129 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 745277008130 TM-ABC transporter signature motif; other site 745277008131 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 745277008132 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 745277008133 Walker A/P-loop; other site 745277008134 ATP binding site [chemical binding]; other site 745277008135 Q-loop/lid; other site 745277008136 ABC transporter signature motif; other site 745277008137 Walker B; other site 745277008138 D-loop; other site 745277008139 H-loop/switch region; other site 745277008140 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 745277008141 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 745277008142 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 745277008143 putative ligand binding site [chemical binding]; other site 745277008144 xylose isomerase; Provisional; Region: PRK05474 745277008145 xylulokinase; Provisional; Region: PRK15027 745277008146 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 745277008147 N- and C-terminal domain interface [polypeptide binding]; other site 745277008148 active site 745277008149 MgATP binding site [chemical binding]; other site 745277008150 catalytic site [active] 745277008151 metal binding site [ion binding]; metal-binding site 745277008152 xylulose binding site [chemical binding]; other site 745277008153 homodimer interface [polypeptide binding]; other site 745277008154 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 745277008155 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 745277008156 putative active site; other site 745277008157 catalytic residue [active] 745277008158 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 745277008159 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 745277008160 ligand binding site [chemical binding]; other site 745277008161 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 745277008162 TM-ABC transporter signature motif; other site 745277008163 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 745277008164 TM-ABC transporter signature motif; other site 745277008165 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 745277008166 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 745277008167 Walker A/P-loop; other site 745277008168 ATP binding site [chemical binding]; other site 745277008169 Q-loop/lid; other site 745277008170 ABC transporter signature motif; other site 745277008171 Walker B; other site 745277008172 D-loop; other site 745277008173 H-loop/switch region; other site 745277008174 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 745277008175 transcriptional regulator LsrR; Provisional; Region: PRK15418 745277008176 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 745277008177 non-specific DNA interactions [nucleotide binding]; other site 745277008178 DNA binding site [nucleotide binding] 745277008179 sequence specific DNA binding site [nucleotide binding]; other site 745277008180 putative cAMP binding site [chemical binding]; other site 745277008181 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 745277008182 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 745277008183 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 745277008184 putative N- and C-terminal domain interface [polypeptide binding]; other site 745277008185 putative active site [active] 745277008186 putative MgATP binding site [chemical binding]; other site 745277008187 catalytic site [active] 745277008188 metal binding site [ion binding]; metal-binding site 745277008189 putative carbohydrate binding site [chemical binding]; other site 745277008190 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 745277008191 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 745277008192 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 745277008193 HlyD family secretion protein; Region: HlyD_3; pfam13437 745277008194 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 745277008195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277008196 putative substrate translocation pore; other site 745277008197 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 745277008198 Outer membrane efflux protein; Region: OEP; pfam02321 745277008199 Outer membrane efflux protein; Region: OEP; pfam02321 745277008200 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 745277008201 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 745277008202 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277008203 short chain dehydrogenase; Provisional; Region: PRK06180 745277008204 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 745277008205 NADP binding site [chemical binding]; other site 745277008206 active site 745277008207 steroid binding site; other site 745277008208 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 745277008209 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 745277008210 oligomer interface [polypeptide binding]; other site 745277008211 metal binding site [ion binding]; metal-binding site 745277008212 metal binding site [ion binding]; metal-binding site 745277008213 putative Cl binding site [ion binding]; other site 745277008214 basic sphincter; other site 745277008215 hydrophobic gate; other site 745277008216 periplasmic entrance; other site 745277008217 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 745277008218 Outer membrane efflux protein; Region: OEP; pfam02321 745277008219 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 745277008220 Outer membrane efflux protein; Region: OEP; pfam02321 745277008221 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 745277008222 HlyD family secretion protein; Region: HlyD_3; pfam13437 745277008223 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 745277008224 MMPL family; Region: MMPL; cl14618 745277008225 putative transposase OrfB; Reviewed; Region: PHA02517 745277008226 HTH-like domain; Region: HTH_21; pfam13276 745277008227 Integrase core domain; Region: rve; pfam00665 745277008228 Integrase core domain; Region: rve_2; pfam13333 745277008229 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 745277008230 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 745277008231 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 745277008232 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 745277008233 Mechanosensitive ion channel; Region: MS_channel; pfam00924 745277008234 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 745277008235 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 745277008236 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 745277008237 Walker A/P-loop; other site 745277008238 ATP binding site [chemical binding]; other site 745277008239 Q-loop/lid; other site 745277008240 ABC transporter signature motif; other site 745277008241 Walker B; other site 745277008242 D-loop; other site 745277008243 H-loop/switch region; other site 745277008244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277008245 D-galactonate transporter; Region: 2A0114; TIGR00893 745277008246 putative substrate translocation pore; other site 745277008247 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 745277008248 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277008249 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 745277008250 dimerization interface [polypeptide binding]; other site 745277008251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399; cl19827 745277008252 Protein of unknown function (DUF445); Region: DUF445; pfam04286 745277008253 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 745277008254 dimer interface [polypeptide binding]; other site 745277008255 active site 745277008256 metal binding site [ion binding]; metal-binding site 745277008257 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 745277008258 CoA-transferase family III; Region: CoA_transf_3; cl19215 745277008259 CoA-transferase family III; Region: CoA_transf_3; pfam02515 745277008260 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 745277008261 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277008262 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 745277008263 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277008264 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 745277008265 galactoside permease; Reviewed; Region: lacY; PRK09528 745277008266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277008267 putative substrate translocation pore; other site 745277008268 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 745277008269 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 745277008270 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 745277008271 DNA binding residues [nucleotide binding] 745277008272 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 745277008273 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 745277008274 dimer interface [polypeptide binding]; other site 745277008275 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 745277008276 dimerization interface [polypeptide binding]; other site 745277008277 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 745277008278 dimer interface [polypeptide binding]; other site 745277008279 putative CheW interface [polypeptide binding]; other site 745277008280 hypothetical protein; Provisional; Region: PRK10708 745277008281 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 745277008282 DNA-binding site [nucleotide binding]; DNA binding site 745277008283 RNA-binding motif; other site 745277008284 Ion transport protein; Region: Ion_trans; pfam00520 745277008285 Ion channel; Region: Ion_trans_2; pfam07885 745277008286 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 745277008287 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 745277008288 putative NAD(P) binding site [chemical binding]; other site 745277008289 putative substrate binding site [chemical binding]; other site 745277008290 catalytic Zn binding site [ion binding]; other site 745277008291 structural Zn binding site [ion binding]; other site 745277008292 dimer interface [polypeptide binding]; other site 745277008293 Domain of unknown function DUF20; Region: UPF0118; cl00465 745277008294 Protein of unknown function (DUF969); Region: DUF969; pfam06149 745277008295 Protein of unknown function (DUF979); Region: DUF979; pfam06166 745277008296 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 745277008297 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 745277008298 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 745277008299 putative trimer interface [polypeptide binding]; other site 745277008300 putative CoA binding site [chemical binding]; other site 745277008301 putative metal dependent hydrolase; Provisional; Region: PRK11598 745277008302 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 745277008303 Sulfatase; Region: Sulfatase; pfam00884 745277008304 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277008305 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277008306 LysR substrate binding domain; Region: LysR_substrate; pfam03466 745277008307 dimerization interface [polypeptide binding]; other site 745277008308 Phenolic Acid Decarboxylase; Region: PAD; cd14241 745277008309 active site 745277008310 dimer interface [polypeptide binding]; other site 745277008311 Putative lysophospholipase; Region: Hydrolase_4; cl19140 745277008312 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 745277008313 phage resistance protein; Provisional; Region: PRK10551 745277008314 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 745277008315 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 745277008316 Glucose-regulated metallo-peptidase M90; Region: Peptidase_M90; cl01267 745277008317 integrase; Provisional; Region: PRK09692 745277008318 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 745277008319 active site 745277008320 Int/Topo IB signature motif; other site 745277008321 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 745277008322 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 745277008323 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 745277008324 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 745277008325 Walker A/P-loop; other site 745277008326 ATP binding site [chemical binding]; other site 745277008327 Q-loop/lid; other site 745277008328 ABC transporter signature motif; other site 745277008329 Walker B; other site 745277008330 D-loop; other site 745277008331 H-loop/switch region; other site 745277008332 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 745277008333 active site 745277008334 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 745277008335 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 745277008336 Autoinducer synthetase; Region: Autoind_synth; cl17404 745277008337 Autoinducer binding domain; Region: Autoind_bind; pfam03472 745277008338 transcriptional regulator TraR; Provisional; Region: PRK13870 745277008339 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 745277008340 DNA binding residues [nucleotide binding] 745277008341 dimerization interface [polypeptide binding]; other site 745277008342 conjugal transfer protein TrbM; Provisional; Region: PRK13893 745277008343 Domain of unknown function DUF87; Region: DUF87; cl19135 745277008344 AAA-like domain; Region: AAA_10; pfam12846 745277008345 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 745277008346 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 745277008347 AAA ATPase domain; Region: AAA_15; pfam13175 745277008348 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745277008349 Walker A/P-loop; other site 745277008350 ATP binding site [chemical binding]; other site 745277008351 AAA domain; Region: AAA_21; pfam13304 745277008352 TIGR02646 family protein; Region: TIGR02646 745277008353 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 745277008354 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 745277008355 Transposase; Region: DEDD_Tnp_IS110; pfam01548 745277008356 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 745277008357 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 745277008358 active site 745277008359 metal binding site [ion binding]; metal-binding site 745277008360 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 745277008361 HTH-like domain; Region: HTH_21; pfam13276 745277008362 Integrase core domain; Region: rve; pfam00665 745277008363 Integrase core domain; Region: rve_3; pfam13683 745277008364 Insertion sequence IS1222 ribosomal frameshifting element; IMG reference gene:2506709700 745277008365 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 745277008366 RNAase interaction site [polypeptide binding]; other site 745277008367 Uncharacterized conserved protein [Function unknown]; Region: COG3391 745277008368 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 745277008369 active site 745277008370 iron coordination sites [ion binding]; other site 745277008371 substrate binding pocket [chemical binding]; other site 745277008372 Predicted permeases [General function prediction only]; Region: COG0679 745277008373 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 745277008374 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 745277008375 Inclusion body protein; Region: PixA; pfam12306 745277008376 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 745277008377 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 745277008378 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 745277008379 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 745277008380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277008381 active site 745277008382 phosphorylation site [posttranslational modification] 745277008383 intermolecular recognition site; other site 745277008384 dimerization interface [polypeptide binding]; other site 745277008385 Helix-turn-helix domain; Region: HTH_18; pfam12833 745277008386 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 745277008387 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; cl09440 745277008388 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 745277008389 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745277008390 dimer interface [polypeptide binding]; other site 745277008391 phosphorylation site [posttranslational modification] 745277008392 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277008393 ATP binding site [chemical binding]; other site 745277008394 Mg2+ binding site [ion binding]; other site 745277008395 G-X-G motif; other site 745277008396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277008397 active site 745277008398 phosphorylation site [posttranslational modification] 745277008399 intermolecular recognition site; other site 745277008400 dimerization interface [polypeptide binding]; other site 745277008401 Protein of unknown function (DUF1401); Region: DUF1401; pfam07180 745277008402 Putative lysophospholipase; Region: Hydrolase_4; cl19140 745277008403 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 745277008404 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 745277008405 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277008406 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277008407 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 745277008408 dimerization interface [polypeptide binding]; other site 745277008409 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 745277008410 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 745277008411 putative DNA binding site [nucleotide binding]; other site 745277008412 putative Zn2+ binding site [ion binding]; other site 745277008413 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 745277008414 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 745277008415 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745277008416 NAD(P) binding site [chemical binding]; other site 745277008417 active site 745277008418 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 745277008419 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745277008420 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 745277008421 HAMP domain; Region: HAMP; pfam00672 745277008422 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 745277008423 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 745277008424 dimer interface [polypeptide binding]; other site 745277008425 putative CheW interface [polypeptide binding]; other site 745277008426 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 745277008427 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 745277008428 cell density-dependent motility repressor; Provisional; Region: PRK10082 745277008429 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277008430 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 745277008431 dimerization interface [polypeptide binding]; other site 745277008432 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 745277008433 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 745277008434 putative active site pocket [active] 745277008435 metal binding site [ion binding]; metal-binding site 745277008436 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 745277008437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745277008438 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 745277008439 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 745277008440 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 745277008441 Thymidylate kinase; Region: Thymidylate_kin; pfam02223 745277008442 TMP-binding site; other site 745277008443 ATP-binding site [chemical binding]; other site 745277008444 Predicted transcriptional regulators [Transcription]; Region: COG1733 745277008445 dimerization interface [polypeptide binding]; other site 745277008446 putative DNA binding site [nucleotide binding]; other site 745277008447 Transcriptional regulators [Transcription]; Region: MarR; COG1846 745277008448 putative Zn2+ binding site [ion binding]; other site 745277008449 short chain dehydrogenase; Provisional; Region: PRK06500 745277008450 classical (c) SDRs; Region: SDR_c; cd05233 745277008451 NAD(P) binding site [chemical binding]; other site 745277008452 active site 745277008453 Methyltransferase domain; Region: Methyltransf_31; pfam13847 745277008454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277008455 S-adenosylmethionine binding site [chemical binding]; other site 745277008456 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 745277008457 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 745277008458 putative NAD(P) binding site [chemical binding]; other site 745277008459 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277008460 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277008461 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 745277008462 putative effector binding pocket; other site 745277008463 dimerization interface [polypeptide binding]; other site 745277008464 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 745277008465 active site 745277008466 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745277008467 Coenzyme A binding pocket [chemical binding]; other site 745277008468 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 745277008469 RNAase interaction site [polypeptide binding]; other site 745277008470 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277008471 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277008472 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 745277008473 putative effector binding pocket; other site 745277008474 dimerization interface [polypeptide binding]; other site 745277008475 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 745277008476 tetramerization interface [polypeptide binding]; other site 745277008477 NAD(P) binding site [chemical binding]; other site 745277008478 catalytic residues [active] 745277008479 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 745277008480 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 745277008481 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 745277008482 NAD(P) binding site [chemical binding]; other site 745277008483 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 745277008484 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 745277008485 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 745277008486 active site 745277008487 metal binding site [ion binding]; metal-binding site 745277008488 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 745277008489 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 745277008490 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745277008491 dimer interface [polypeptide binding]; other site 745277008492 phosphorylation site [posttranslational modification] 745277008493 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277008494 ATP binding site [chemical binding]; other site 745277008495 Mg2+ binding site [ion binding]; other site 745277008496 G-X-G motif; other site 745277008497 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 745277008498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277008499 active site 745277008500 phosphorylation site [posttranslational modification] 745277008501 intermolecular recognition site; other site 745277008502 dimerization interface [polypeptide binding]; other site 745277008503 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 745277008504 DNA binding site [nucleotide binding] 745277008505 MltA-interacting protein MipA; Region: MipA; cl01504 745277008506 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 745277008507 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 745277008508 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 745277008509 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 745277008510 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 745277008511 Domain of unknown function (DUF4098); Region: DUF4098; cl19992 745277008512 Salmonella virulence plasmid 28.1kDa A protein; Region: VRP1; pfam03538 745277008513 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 745277008514 putative homodimer interface [polypeptide binding]; other site 745277008515 putative homotetramer interface [polypeptide binding]; other site 745277008516 transcriptional regulator SpvR; Provisional; Region: PRK15243 745277008517 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277008518 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 745277008519 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 745277008520 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 745277008521 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 745277008522 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 745277008523 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 745277008524 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 745277008525 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 745277008526 Salmonella virulence plasmid 28.1kDa A protein; Region: VRP1; pfam03538 745277008527 ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Region: ectoine_ehuD; TIGR03003 745277008528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277008529 dimer interface [polypeptide binding]; other site 745277008530 conserved gate region; other site 745277008531 ABC-ATPase subunit interface; other site 745277008532 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 745277008533 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 745277008534 Walker A/P-loop; other site 745277008535 ATP binding site [chemical binding]; other site 745277008536 Q-loop/lid; other site 745277008537 ABC transporter signature motif; other site 745277008538 Walker B; other site 745277008539 D-loop; other site 745277008540 H-loop/switch region; other site 745277008541 NIL domain; Region: NIL; cl09633 745277008542 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 745277008543 Sulfatase; Region: Sulfatase; cl19157 745277008544 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 745277008545 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 745277008546 Walker A/P-loop; other site 745277008547 ATP binding site [chemical binding]; other site 745277008548 Q-loop/lid; other site 745277008549 ABC transporter signature motif; other site 745277008550 Walker B; other site 745277008551 D-loop; other site 745277008552 H-loop/switch region; other site 745277008553 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 745277008554 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 745277008555 Walker A/P-loop; other site 745277008556 ATP binding site [chemical binding]; other site 745277008557 Q-loop/lid; other site 745277008558 ABC transporter signature motif; other site 745277008559 Walker B; other site 745277008560 D-loop; other site 745277008561 H-loop/switch region; other site 745277008562 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 745277008563 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 745277008564 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 745277008565 TM-ABC transporter signature motif; other site 745277008566 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 745277008567 TM-ABC transporter signature motif; other site 745277008568 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 745277008569 dimerization interface [polypeptide binding]; other site 745277008570 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 745277008571 ligand binding site [chemical binding]; other site 745277008572 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 745277008573 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 745277008574 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 745277008575 dimer interface [polypeptide binding]; other site 745277008576 active site 745277008577 Schiff base residues; other site 745277008578 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 745277008579 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 745277008580 putative active site [active] 745277008581 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 745277008582 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745277008583 Walker A/P-loop; other site 745277008584 ATP binding site [chemical binding]; other site 745277008585 Q-loop/lid; other site 745277008586 ABC transporter signature motif; other site 745277008587 Walker B; other site 745277008588 D-loop; other site 745277008589 H-loop/switch region; other site 745277008590 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 745277008591 HlyD family secretion protein; Region: HlyD; pfam00529 745277008592 HlyD family secretion protein; Region: HlyD_3; pfam13437 745277008593 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 745277008594 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 745277008595 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 745277008596 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 745277008597 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 745277008598 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 745277008599 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 745277008600 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 745277008601 hypothetical protein; Provisional; Region: PRK05415 745277008602 Predicted membrane protein [Function unknown]; Region: COG3768 745277008603 Predicted ATPase [General function prediction only]; Region: COG3106 745277008604 Phage shock protein PspD (Phageshock_PspD); Region: Phageshock_PspD; cl11512 745277008605 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 745277008606 phage shock protein C; Region: phageshock_pspC; TIGR02978 745277008607 phage shock protein B; Provisional; Region: pspB; PRK09458 745277008608 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 745277008609 phage shock protein PspA; Provisional; Region: PRK10698 745277008610 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 745277008611 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745277008612 Walker A motif; other site 745277008613 ATP binding site [chemical binding]; other site 745277008614 Walker B motif; other site 745277008615 arginine finger; other site 745277008616 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 745277008617 antimicrobial peptide ABC transporter periplasmic binding protein SapA; Provisional; Region: PRK15109 745277008618 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 745277008619 peptide binding site [polypeptide binding]; other site 745277008620 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapB; COG4168 745277008621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277008622 dimer interface [polypeptide binding]; other site 745277008623 conserved gate region; other site 745277008624 putative PBP binding loops; other site 745277008625 ABC-ATPase subunit interface; other site 745277008626 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 745277008627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277008628 dimer interface [polypeptide binding]; other site 745277008629 conserved gate region; other site 745277008630 putative PBP binding loops; other site 745277008631 ABC-ATPase subunit interface; other site 745277008632 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 745277008633 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277008634 Walker A/P-loop; other site 745277008635 ATP binding site [chemical binding]; other site 745277008636 Q-loop/lid; other site 745277008637 ABC transporter signature motif; other site 745277008638 Walker B; other site 745277008639 D-loop; other site 745277008640 H-loop/switch region; other site 745277008641 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745277008642 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 745277008643 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277008644 Walker A/P-loop; other site 745277008645 ATP binding site [chemical binding]; other site 745277008646 Q-loop/lid; other site 745277008647 ABC transporter signature motif; other site 745277008648 Walker B; other site 745277008649 D-loop; other site 745277008650 H-loop/switch region; other site 745277008651 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745277008652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 745277008653 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 745277008654 Uncharacterized conserved protein [Function unknown]; Region: COG2128 745277008655 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 745277008656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277008657 putative substrate translocation pore; other site 745277008658 POT family; Region: PTR2; pfam00854 745277008659 GAF domain; Region: GAF; pfam01590 745277008660 PAS domain S-box; Region: sensory_box; TIGR00229 745277008661 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 745277008662 putative active site [active] 745277008663 heme pocket [chemical binding]; other site 745277008664 PAS domain S-box; Region: sensory_box; TIGR00229 745277008665 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745277008666 metal binding site [ion binding]; metal-binding site 745277008667 active site 745277008668 I-site; other site 745277008669 Helix-turn-helix domain; Region: HTH_18; pfam12833 745277008670 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277008671 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 745277008672 PAS domain; Region: PAS_9; pfam13426 745277008673 putative active site [active] 745277008674 heme pocket [chemical binding]; other site 745277008675 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745277008676 metal binding site [ion binding]; metal-binding site 745277008677 active site 745277008678 I-site; other site 745277008679 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 745277008680 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 745277008681 dimer interface [polypeptide binding]; other site 745277008682 active site 745277008683 catalytic residue [active] 745277008684 glutathionine S-transferase; Provisional; Region: PRK10542 745277008685 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 745277008686 C-terminal domain interface [polypeptide binding]; other site 745277008687 GSH binding site (G-site) [chemical binding]; other site 745277008688 dimer interface [polypeptide binding]; other site 745277008689 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 745277008690 dimer interface [polypeptide binding]; other site 745277008691 N-terminal domain interface [polypeptide binding]; other site 745277008692 substrate binding pocket (H-site) [chemical binding]; other site 745277008693 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 745277008694 dimer interface [polypeptide binding]; other site 745277008695 pyridoxal binding site [chemical binding]; other site 745277008696 ATP binding site [chemical binding]; other site 745277008697 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 745277008698 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 745277008699 active site 745277008700 HIGH motif; other site 745277008701 dimer interface [polypeptide binding]; other site 745277008702 KMSKS motif; other site 745277008703 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 745277008704 RNA binding surface [nucleotide binding]; other site 745277008705 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 745277008706 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 745277008707 Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590 745277008708 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 745277008709 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 745277008710 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 745277008711 transcriptional regulator SlyA; Provisional; Region: PRK03573 745277008712 Transcriptional regulators [Transcription]; Region: MarR; COG1846 745277008713 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 745277008714 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 745277008715 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 745277008716 HlyD family secretion protein; Region: HlyD_3; pfam13437 745277008717 Fusaric acid resistance protein family; Region: FUSC; pfam04632 745277008718 Fusaric acid resistance protein-like; Region: FUSC_2; cl19401 745277008719 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 745277008720 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 745277008721 active site 745277008722 catalytic tetrad [active] 745277008723 Predicted Fe-S protein [General function prediction only]; Region: COG3313 745277008724 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 745277008725 FMN binding site [chemical binding]; other site 745277008726 active site 745277008727 substrate binding site [chemical binding]; other site 745277008728 catalytic residue [active] 745277008729 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 745277008730 dimer interface [polypeptide binding]; other site 745277008731 active site 745277008732 metal binding site [ion binding]; metal-binding site 745277008733 glutathione binding site [chemical binding]; other site 745277008734 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 745277008735 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 745277008736 dimer interface [polypeptide binding]; other site 745277008737 catalytic site [active] 745277008738 putative active site [active] 745277008739 putative substrate binding site [chemical binding]; other site 745277008740 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 745277008741 putative GSH binding site [chemical binding]; other site 745277008742 catalytic residues [active] 745277008743 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 745277008744 NlpC/P60 family; Region: NLPC_P60; pfam00877 745277008745 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 745277008746 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745277008747 DNA binding site [nucleotide binding] 745277008748 domain linker motif; other site 745277008749 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 745277008750 dimerization interface [polypeptide binding]; other site 745277008751 ligand binding site [chemical binding]; other site 745277008752 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 745277008753 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277008754 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 745277008755 dimerization interface [polypeptide binding]; other site 745277008756 putative transporter; Provisional; Region: PRK11043 745277008757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277008758 putative substrate translocation pore; other site 745277008759 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 745277008760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277008761 S-adenosylmethionine binding site [chemical binding]; other site 745277008762 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 745277008763 Lumazine binding domain; Region: Lum_binding; pfam00677 745277008764 Lumazine binding domain; Region: Lum_binding; pfam00677 745277008765 multidrug efflux protein; Reviewed; Region: PRK01766 745277008766 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 745277008767 cation binding site [ion binding]; other site 745277008768 pyruvate kinase; Provisional; Region: PRK09206 745277008769 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 745277008770 domain interfaces; other site 745277008771 active site 745277008772 murein lipoprotein; Provisional; Region: PRK15396 745277008773 L,D-transpeptidase; Provisional; Region: PRK10190 745277008774 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 745277008775 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 745277008776 cysteine desufuration protein SufE; Provisional; Region: PRK09296 745277008777 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 745277008778 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 745277008779 catalytic residue [active] 745277008780 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 745277008781 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 745277008782 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 745277008783 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 745277008784 Walker A/P-loop; other site 745277008785 ATP binding site [chemical binding]; other site 745277008786 Q-loop/lid; other site 745277008787 ABC transporter signature motif; other site 745277008788 Walker B; other site 745277008789 D-loop; other site 745277008790 H-loop/switch region; other site 745277008791 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 745277008792 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 745277008793 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 745277008794 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 745277008795 CoenzymeA binding site [chemical binding]; other site 745277008796 subunit interaction site [polypeptide binding]; other site 745277008797 PHB binding site; other site 745277008798 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 745277008799 FAD binding domain; Region: FAD_binding_4; pfam01565 745277008800 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 745277008801 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 745277008802 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 745277008803 putative inner membrane protein; Provisional; Region: PRK10983 745277008804 phosphoenolpyruvate synthase; Validated; Region: PRK06464 745277008805 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 745277008806 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 745277008807 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 745277008808 PEP synthetase regulatory protein; Provisional; Region: PRK05339 745277008809 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 745277008810 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 745277008811 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 745277008812 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 745277008813 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 745277008814 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 745277008815 putative hemin binding site; other site 745277008816 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 745277008817 ABC-ATPase subunit interface; other site 745277008818 dimer interface [polypeptide binding]; other site 745277008819 putative PBP binding regions; other site 745277008820 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 745277008821 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 745277008822 Walker A/P-loop; other site 745277008823 ATP binding site [chemical binding]; other site 745277008824 Q-loop/lid; other site 745277008825 ABC transporter signature motif; other site 745277008826 Walker B; other site 745277008827 D-loop; other site 745277008828 H-loop/switch region; other site 745277008829 hypothetical protein; Validated; Region: PRK00029 745277008830 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 745277008831 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 745277008832 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 745277008833 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 745277008834 NlpC/P60 family; Region: NLPC_P60; pfam00877 745277008835 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 745277008836 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 745277008837 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 745277008838 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 745277008839 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 745277008840 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 745277008841 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 745277008842 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 745277008843 active site 745277008844 substrate binding site [chemical binding]; other site 745277008845 cosubstrate binding site; other site 745277008846 catalytic site [active] 745277008847 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 745277008848 active site 745277008849 hexamer interface [polypeptide binding]; other site 745277008850 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 745277008851 NAD binding site [chemical binding]; other site 745277008852 substrate binding site [chemical binding]; other site 745277008853 active site 745277008854 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 745277008855 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 745277008856 Ligand binding site; other site 745277008857 Putative Catalytic site; other site 745277008858 DXD motif; other site 745277008859 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 745277008860 inhibitor-cofactor binding pocket; inhibition site 745277008861 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277008862 catalytic residue [active] 745277008863 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 745277008864 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 745277008865 Walker A/P-loop; other site 745277008866 ATP binding site [chemical binding]; other site 745277008867 Q-loop/lid; other site 745277008868 ABC transporter signature motif; other site 745277008869 Walker B; other site 745277008870 D-loop; other site 745277008871 H-loop/switch region; other site 745277008872 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 745277008873 catalytic residues [active] 745277008874 dimer interface [polypeptide binding]; other site 745277008875 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 745277008876 ABC-ATPase subunit interface; other site 745277008877 dimer interface [polypeptide binding]; other site 745277008878 putative PBP binding regions; other site 745277008879 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 745277008880 ResB-like family; Region: ResB; cl09125 745277008881 Alpha subunit of integration host factor (IHFA); Region: IHF_A; cd13835 745277008882 DNA binding site [nucleotide binding] 745277008883 dimer interface [polypeptide binding]; other site 745277008884 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 745277008885 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 745277008886 putative tRNA-binding site [nucleotide binding]; other site 745277008887 B3/4 domain; Region: B3_4; pfam03483 745277008888 tRNA synthetase B5 domain; Region: B5; smart00874 745277008889 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 745277008890 dimer interface [polypeptide binding]; other site 745277008891 motif 1; other site 745277008892 motif 3; other site 745277008893 motif 2; other site 745277008894 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 745277008895 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 745277008896 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 745277008897 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 745277008898 dimer interface [polypeptide binding]; other site 745277008899 motif 1; other site 745277008900 active site 745277008901 motif 2; other site 745277008902 motif 3; other site 745277008903 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 745277008904 23S rRNA binding site [nucleotide binding]; other site 745277008905 L21 binding site [polypeptide binding]; other site 745277008906 L13 binding site [polypeptide binding]; other site 745277008907 Long range pseudoknot; IMG reference gene:2506709889 745277008908 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 745277008909 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 745277008910 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 745277008911 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 745277008912 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 745277008913 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 745277008914 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 745277008915 active site 745277008916 dimer interface [polypeptide binding]; other site 745277008917 motif 1; other site 745277008918 motif 2; other site 745277008919 motif 3; other site 745277008920 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 745277008921 anticodon binding site; other site 745277008922 inner membrane protein; Provisional; Region: PRK10995 745277008923 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 745277008924 N-acetyl-D-glucosamine binding site [chemical binding]; other site 745277008925 catalytic residue [active] 745277008926 Phosphotransferase enzyme family; Region: APH; pfam01636 745277008927 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 745277008928 active site 745277008929 substrate binding site [chemical binding]; other site 745277008930 ATP binding site [chemical binding]; other site 745277008931 YniB-like protein; Region: YniB; pfam14002 745277008932 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 745277008933 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 745277008934 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745277008935 motif II; other site 745277008936 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 745277008937 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 745277008938 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 745277008939 NADP binding site [chemical binding]; other site 745277008940 homodimer interface [polypeptide binding]; other site 745277008941 active site 745277008942 inner membrane protein; Provisional; Region: PRK11648 745277008943 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 745277008944 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 745277008945 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 745277008946 dimerization interface [polypeptide binding]; other site 745277008947 putative Zn2+ binding site [ion binding]; other site 745277008948 putative DNA binding site [nucleotide binding]; other site 745277008949 Bacterial transcriptional regulator; Region: IclR; pfam01614 745277008950 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 745277008951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277008952 putative substrate translocation pore; other site 745277008953 heat shock protein HtpX; Provisional; Region: PRK05457 745277008954 carboxy-terminal protease; Provisional; Region: PRK11186 745277008955 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 745277008956 protein binding site [polypeptide binding]; other site 745277008957 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 745277008958 Catalytic dyad [active] 745277008959 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 745277008960 ProP expression regulator; Provisional; Region: PRK04950 745277008961 putative RNA binding sites [nucleotide binding]; other site 745277008962 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 745277008963 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 745277008964 Paraquat-inducible protein A; Region: PqiA; pfam04403 745277008965 Paraquat-inducible protein A; Region: PqiA; pfam04403 745277008966 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 745277008967 mce related protein; Region: MCE; pfam02470 745277008968 mce related protein; Region: MCE; pfam02470 745277008969 mce related protein; Region: MCE; pfam02470 745277008970 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 745277008971 mce related protein; Region: MCE; pfam02470 745277008972 mce related protein; Region: MCE; pfam02470 745277008973 mce related protein; Region: MCE; pfam02470 745277008974 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 745277008975 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277008976 S-adenosylmethionine binding site [chemical binding]; other site 745277008977 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; cl19835 745277008978 PAS domain; Region: PAS_9; pfam13426 745277008979 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 745277008980 putative active site [active] 745277008981 heme pocket [chemical binding]; other site 745277008982 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 745277008983 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 745277008984 putative active site [active] 745277008985 heme pocket [chemical binding]; other site 745277008986 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 745277008987 putative active site [active] 745277008988 heme pocket [chemical binding]; other site 745277008989 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745277008990 metal binding site [ion binding]; metal-binding site 745277008991 active site 745277008992 I-site; other site 745277008993 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 745277008994 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 745277008995 WG containing repeat; Region: WG_beta_rep; pfam14903 745277008996 WG containing repeat; Region: WG_beta_rep; pfam14903 745277008997 WG containing repeat; Region: WG_beta_rep; pfam14903 745277008998 WG containing repeat; Region: WG_beta_rep; pfam14903 745277008999 WG containing repeat; Region: WG_beta_rep; pfam14903 745277009000 WG containing repeat; Region: WG_beta_rep; pfam14903 745277009001 WG containing repeat; Region: WG_beta_rep; pfam14903 745277009002 WG containing repeat; Region: WG_beta_rep; pfam14903 745277009003 WG containing repeat; Region: WG_beta_rep; pfam14903 745277009004 WG containing repeat; Region: WG_beta_rep; pfam14903 745277009005 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 745277009006 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 745277009007 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 745277009008 metal binding site [ion binding]; metal-binding site 745277009009 putative dimer interface [polypeptide binding]; other site 745277009010 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 745277009011 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 745277009012 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 745277009013 NAD binding site [chemical binding]; other site 745277009014 substrate binding site [chemical binding]; other site 745277009015 catalytic Zn binding site [ion binding]; other site 745277009016 tetramer interface [polypeptide binding]; other site 745277009017 structural Zn binding site [ion binding]; other site 745277009018 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 745277009019 HAMP domain; Region: HAMP; pfam00672 745277009020 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 745277009021 dimer interface [polypeptide binding]; other site 745277009022 putative CheW interface [polypeptide binding]; other site 745277009023 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 745277009024 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 745277009025 Alkyl sulfatase dimerization; Region: Alkyl_sulf_dimr; pfam14863 745277009026 Alkyl sulfatase C-terminal; Region: Alkyl_sulf_C; pfam14864 745277009027 Cation efflux family; Region: Cation_efflux; cl00316 745277009028 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 745277009029 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745277009030 Coenzyme A binding pocket [chemical binding]; other site 745277009031 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 745277009032 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 745277009033 CopC domain; Region: CopC; cl01012 745277009034 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 745277009035 Ferritin-like domain; Region: Ferritin; pfam00210 745277009036 ferroxidase diiron center [ion binding]; other site 745277009037 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 745277009038 Putative lysophospholipase; Region: Hydrolase_4; cl19140 745277009039 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 745277009040 protease 2; Provisional; Region: PRK10115 745277009041 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 745277009042 YebF-like protein; Region: YebF; cl10126 745277009043 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 745277009044 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 745277009045 ATP binding site [chemical binding]; other site 745277009046 Mg++ binding site [ion binding]; other site 745277009047 motif III; other site 745277009048 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 745277009049 nucleotide binding region [chemical binding]; other site 745277009050 ATP-binding site [chemical binding]; other site 745277009051 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 745277009052 putative RNA binding site [nucleotide binding]; other site 745277009053 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 745277009054 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745277009055 ATP-grasp domain; Region: ATP-grasp; pfam02222 745277009056 hypothetical protein; Provisional; Region: PRK05114 745277009057 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 745277009058 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 745277009059 chorismate binding enzyme; Region: Chorismate_bind; cl10555 745277009060 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 745277009061 putative active site [active] 745277009062 putative CoA binding site [chemical binding]; other site 745277009063 nudix motif; other site 745277009064 metal binding site [ion binding]; metal-binding site 745277009065 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 745277009066 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 745277009067 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 745277009068 phage resistance protein; Provisional; Region: PRK10551 745277009069 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 745277009070 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 745277009071 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 745277009072 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 745277009073 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 745277009074 Transporter associated domain; Region: CorC_HlyC; smart01091 745277009075 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 745277009076 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 745277009077 active pocket/dimerization site; other site 745277009078 active site 745277009079 phosphorylation site [posttranslational modification] 745277009080 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 745277009081 active site 745277009082 phosphorylation site [posttranslational modification] 745277009083 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 745277009084 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 745277009085 hypothetical protein; Provisional; Region: PRK02913 745277009086 hypothetical protein; Provisional; Region: PRK11469 745277009087 Domain of unknown function DUF; Region: DUF204; pfam02659 745277009088 Domain of unknown function DUF; Region: DUF204; pfam02659 745277009089 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 745277009090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277009091 S-adenosylmethionine binding site [chemical binding]; other site 745277009092 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 745277009093 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 745277009094 DNA-binding site [nucleotide binding]; DNA binding site 745277009095 RNA-binding motif; other site 745277009096 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 745277009097 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 745277009098 Protein of unknown function (DUF2591); Region: DUF2591; cl11584 745277009099 YebO-like protein; Region: YebO; pfam13974 745277009100 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 745277009101 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 745277009102 Autotransporter beta-domain; Region: Autotransporter; pfam03797 745277009103 YobH-like protein; Region: YobH; pfam13996 745277009104 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 745277009105 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 745277009106 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 745277009107 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 745277009108 peptide binding site [polypeptide binding]; other site 745277009109 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 745277009110 isocitrate dehydrogenase; Reviewed; Region: PRK07006 745277009111 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 745277009112 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 745277009113 probable active site [active] 745277009114 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 745277009115 nudix motif; other site 745277009116 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 745277009117 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 745277009118 Ligand Binding Site [chemical binding]; other site 745277009119 putative lysogenization regulator; Reviewed; Region: PRK00218 745277009120 adenylosuccinate lyase; Provisional; Region: PRK09285 745277009121 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 745277009122 tetramer interface [polypeptide binding]; other site 745277009123 active site 745277009124 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 745277009125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277009126 active site 745277009127 phosphorylation site [posttranslational modification] 745277009128 intermolecular recognition site; other site 745277009129 dimerization interface [polypeptide binding]; other site 745277009130 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 745277009131 DNA binding site [nucleotide binding] 745277009132 sensor protein PhoQ; Provisional; Region: PRK10815 745277009133 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 745277009134 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745277009135 dimer interface [polypeptide binding]; other site 745277009136 phosphorylation site [posttranslational modification] 745277009137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277009138 ATP binding site [chemical binding]; other site 745277009139 Mg2+ binding site [ion binding]; other site 745277009140 G-X-G motif; other site 745277009141 Uncharacterized conserved protein [Function unknown]; Region: COG2850 745277009142 peptidase T-like protein; Region: PepT-like; TIGR01883 745277009143 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 745277009144 metal binding site [ion binding]; metal-binding site 745277009145 dimer interface [polypeptide binding]; other site 745277009146 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 745277009147 NAD+ binding site [chemical binding]; other site 745277009148 substrate binding site [chemical binding]; other site 745277009149 Zn binding site [ion binding]; other site 745277009150 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 745277009151 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 745277009152 FtsX-like permease family; Region: FtsX; pfam02687 745277009153 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 745277009154 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 745277009155 Walker A/P-loop; other site 745277009156 ATP binding site [chemical binding]; other site 745277009157 Q-loop/lid; other site 745277009158 ABC transporter signature motif; other site 745277009159 Walker B; other site 745277009160 D-loop; other site 745277009161 H-loop/switch region; other site 745277009162 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 745277009163 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 745277009164 FtsX-like permease family; Region: FtsX; pfam02687 745277009165 transcription-repair coupling factor; Provisional; Region: PRK10689 745277009166 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 745277009167 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 745277009168 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 745277009169 ATP binding site [chemical binding]; other site 745277009170 putative Mg++ binding site [ion binding]; other site 745277009171 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 745277009172 nucleotide binding region [chemical binding]; other site 745277009173 ATP-binding site [chemical binding]; other site 745277009174 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 745277009175 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 745277009176 Ligand binding site; other site 745277009177 metal-binding site 745277009178 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 745277009179 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 745277009180 XdhC Rossmann domain; Region: XdhC_C; pfam13478 745277009181 hypothetical protein; Provisional; Region: PRK11280 745277009182 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 745277009183 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 745277009184 hypothetical protein; Provisional; Region: PRK04940 745277009185 beta-hexosaminidase; Provisional; Region: PRK05337 745277009186 Phosphotransferase enzyme family; Region: APH; pfam01636 745277009187 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 745277009188 active site 745277009189 substrate binding site [chemical binding]; other site 745277009190 ATP binding site [chemical binding]; other site 745277009191 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 745277009192 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 745277009193 putative dimer interface [polypeptide binding]; other site 745277009194 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 745277009195 nucleotide binding site/active site [active] 745277009196 HIT family signature motif; other site 745277009197 catalytic residue [active] 745277009198 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 745277009199 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 745277009200 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 745277009201 active site turn [active] 745277009202 phosphorylation site [posttranslational modification] 745277009203 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 745277009204 active site 745277009205 DNA polymerase III subunit delta'; Validated; Region: PRK07993 745277009206 DNA polymerase III subunit delta'; Validated; Region: PRK08485 745277009207 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 745277009208 thymidylate kinase; Validated; Region: tmk; PRK00698 745277009209 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 745277009210 TMP-binding site; other site 745277009211 ATP-binding site [chemical binding]; other site 745277009212 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 745277009213 dimerization interface [polypeptide binding]; other site 745277009214 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 745277009215 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277009216 catalytic residue [active] 745277009217 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 745277009218 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 745277009219 dimer interface [polypeptide binding]; other site 745277009220 active site 745277009221 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 745277009222 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 745277009223 NAD(P) binding site [chemical binding]; other site 745277009224 homotetramer interface [polypeptide binding]; other site 745277009225 homodimer interface [polypeptide binding]; other site 745277009226 active site 745277009227 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 745277009228 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 745277009229 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 745277009230 dimer interface [polypeptide binding]; other site 745277009231 active site 745277009232 CoA binding pocket [chemical binding]; other site 745277009233 putative phosphate acyltransferase; Provisional; Region: PRK05331 745277009234 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 745277009235 hypothetical protein; Provisional; Region: PRK11193 745277009236 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 745277009237 active site 745277009238 dimer interface [polypeptide binding]; other site 745277009239 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 745277009240 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 745277009241 RNA binding surface [nucleotide binding]; other site 745277009242 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 745277009243 active site 745277009244 ribonuclease E; Reviewed; Region: rne; PRK10811 745277009245 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 745277009246 homodimer interface [polypeptide binding]; other site 745277009247 oligonucleotide binding site [chemical binding]; other site 745277009248 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 745277009249 Mitochondria Localisation Sequence; Region: AIF-MLS; pfam14962 745277009250 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 745277009251 Uncharacterized conserved protein [Function unknown]; Region: COG1359 745277009252 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 745277009253 active site 745277009254 substrate binding pocket [chemical binding]; other site 745277009255 dimer interface [polypeptide binding]; other site 745277009256 DinI-like family; Region: DinI; cl11630 745277009257 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 745277009258 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 745277009259 FAD dependent oxidoreductase; Region: DAO; pfam01266 745277009260 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 745277009261 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 745277009262 DNA binding residues [nucleotide binding] 745277009263 dimerization interface [polypeptide binding]; other site 745277009264 Domain of unknown function DUF20; Region: UPF0118; cl00465 745277009265 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 745277009266 MMPL family; Region: MMPL; cl14618 745277009267 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 745277009268 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 745277009269 HlyD family secretion protein; Region: HlyD_3; pfam13437 745277009270 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 745277009271 hypothetical protein; Provisional; Region: PRK03757 745277009272 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 745277009273 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 745277009274 active site residue [active] 745277009275 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 745277009276 active site 745277009277 FMN binding site [chemical binding]; other site 745277009278 substrate binding site [chemical binding]; other site 745277009279 homotetramer interface [polypeptide binding]; other site 745277009280 catalytic residue [active] 745277009281 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 745277009282 putative acyl-acceptor binding pocket; other site 745277009283 DoxX; Region: DoxX; pfam07681 745277009284 drug efflux system protein MdtG; Provisional; Region: PRK09874 745277009285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277009286 putative substrate translocation pore; other site 745277009287 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 745277009288 active site 745277009289 Protein of unknown function (DUF796); Region: DUF796; cl01226 745277009290 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 745277009291 MsyB protein; Region: MsyB; cl08181 745277009292 lipoprotein; Provisional; Region: PRK10175 745277009293 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 745277009294 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 745277009295 Ligand binding site; other site 745277009296 DXD motif; other site 745277009297 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 745277009298 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 745277009299 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 745277009300 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 745277009301 HlyD family secretion protein; Region: HlyD_3; pfam13437 745277009302 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 745277009303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277009304 putative substrate translocation pore; other site 745277009305 Transcriptional regulator [Transcription]; Region: IclR; COG1414 745277009306 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 745277009307 putative DNA binding site [nucleotide binding]; other site 745277009308 putative Zn2+ binding site [ion binding]; other site 745277009309 Bacterial transcriptional regulator; Region: IclR; pfam01614 745277009310 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 745277009311 Ligand Binding Site [chemical binding]; other site 745277009312 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 745277009313 YccJ-like protein; Region: YccJ; cl08091 745277009314 Inner membrane protein YlaC; Region: YlaC; pfam10777 745277009315 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 745277009316 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 745277009317 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 745277009318 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 745277009319 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 745277009320 active site 745277009321 metal binding site [ion binding]; metal-binding site 745277009322 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 745277009323 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 745277009324 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 745277009325 GIY-YIG motif/motif A; other site 745277009326 active site 745277009327 catalytic site [active] 745277009328 putative DNA binding site [nucleotide binding]; other site 745277009329 metal binding site [ion binding]; metal-binding site 745277009330 UvrB/uvrC motif; Region: UVR; pfam02151 745277009331 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 745277009332 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 745277009333 response regulator; Provisional; Region: PRK09483 745277009334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277009335 active site 745277009336 phosphorylation site [posttranslational modification] 745277009337 intermolecular recognition site; other site 745277009338 dimerization interface [polypeptide binding]; other site 745277009339 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 745277009340 DNA binding residues [nucleotide binding] 745277009341 dimerization interface [polypeptide binding]; other site 745277009342 hypothetical protein; Provisional; Region: PRK10613 745277009343 Cupin domain; Region: Cupin_2; cl17218 745277009344 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277009345 Helix-turn-helix domain; Region: HTH_18; pfam12833 745277009346 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277009347 2-isopropylmalate synthase; Validated; Region: PRK03739 745277009348 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 745277009349 active site 745277009350 catalytic residues [active] 745277009351 metal binding site [ion binding]; metal-binding site 745277009352 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 745277009353 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 745277009354 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 745277009355 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 745277009356 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 745277009357 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 745277009358 Putative glucoamylase; Region: Glycoamylase; cl19893 745277009359 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 745277009360 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 745277009361 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745277009362 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 745277009363 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 745277009364 active site 745277009365 dimer interface [polypeptide binding]; other site 745277009366 non-prolyl cis peptide bond; other site 745277009367 insertion regions; other site 745277009368 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 745277009369 catalytic triad [active] 745277009370 conserved cis-peptide bond; other site 745277009371 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 745277009372 homotrimer interaction site [polypeptide binding]; other site 745277009373 putative active site [active] 745277009374 pyrimidine utilization protein D; Region: RutD; TIGR03611 745277009375 Putative lysophospholipase; Region: Hydrolase_4; cl19140 745277009376 Putative lysophospholipase; Region: Hydrolase_4; cl19140 745277009377 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 745277009378 Sulfate transporter family; Region: Sulfate_transp; cl19250 745277009379 uracil-xanthine permease; Region: ncs2; TIGR00801 745277009380 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 745277009381 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 745277009382 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 745277009383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277009384 dimer interface [polypeptide binding]; other site 745277009385 conserved gate region; other site 745277009386 putative PBP binding loops; other site 745277009387 ABC-ATPase subunit interface; other site 745277009388 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 745277009389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277009390 dimer interface [polypeptide binding]; other site 745277009391 conserved gate region; other site 745277009392 putative PBP binding loops; other site 745277009393 ABC-ATPase subunit interface; other site 745277009394 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 745277009395 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277009396 Walker A/P-loop; other site 745277009397 ATP binding site [chemical binding]; other site 745277009398 Q-loop/lid; other site 745277009399 ABC transporter signature motif; other site 745277009400 Walker B; other site 745277009401 D-loop; other site 745277009402 H-loop/switch region; other site 745277009403 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277009404 Walker A/P-loop; other site 745277009405 ATP binding site [chemical binding]; other site 745277009406 Q-loop/lid; other site 745277009407 ABC transporter signature motif; other site 745277009408 Walker B; other site 745277009409 D-loop; other site 745277009410 H-loop/switch region; other site 745277009411 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 745277009412 CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029 745277009413 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 745277009414 Uncharacterized conserved protein [Function unknown]; Region: COG2128 745277009415 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 745277009416 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 745277009417 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 745277009418 Walker A/P-loop; other site 745277009419 ATP binding site [chemical binding]; other site 745277009420 Q-loop/lid; other site 745277009421 ABC transporter signature motif; other site 745277009422 Walker B; other site 745277009423 D-loop; other site 745277009424 H-loop/switch region; other site 745277009425 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 745277009426 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 745277009427 TM-ABC transporter signature motif; other site 745277009428 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 745277009429 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745277009430 Coenzyme A binding pocket [chemical binding]; other site 745277009431 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 745277009432 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745277009433 non-specific DNA binding site [nucleotide binding]; other site 745277009434 salt bridge; other site 745277009435 sequence-specific DNA binding site [nucleotide binding]; other site 745277009436 Cupin domain; Region: Cupin_2; cl17218 745277009437 transcriptional regulator MirA; Provisional; Region: PRK15043 745277009438 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 745277009439 DNA binding residues [nucleotide binding] 745277009440 SnoaL-like domain; Region: SnoaL_2; pfam12680 745277009441 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 745277009442 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745277009443 NAD(P) binding site [chemical binding]; other site 745277009444 active site 745277009445 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 745277009446 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 745277009447 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 745277009448 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 745277009449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277009450 S-adenosylmethionine binding site [chemical binding]; other site 745277009451 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 745277009452 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 745277009453 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 745277009454 EamA-like transporter family; Region: EamA; pfam00892 745277009455 EamA-like transporter family; Region: EamA; pfam00892 745277009456 hypothetical protein; Provisional; Region: PRK13681 745277009457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277009458 dimer interface [polypeptide binding]; other site 745277009459 conserved gate region; other site 745277009460 putative PBP binding loops; other site 745277009461 ABC-ATPase subunit interface; other site 745277009462 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 745277009463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745277009464 Walker A/P-loop; other site 745277009465 ATP binding site [chemical binding]; other site 745277009466 Q-loop/lid; other site 745277009467 ABC transporter signature motif; other site 745277009468 Walker B; other site 745277009469 D-loop; other site 745277009470 H-loop/switch region; other site 745277009471 CBS domain; Region: CBS; pfam00571 745277009472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277009473 dimer interface [polypeptide binding]; other site 745277009474 conserved gate region; other site 745277009475 putative PBP binding loops; other site 745277009476 ABC-ATPase subunit interface; other site 745277009477 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 745277009478 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 745277009479 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 745277009480 NAD(P) binding site [chemical binding]; other site 745277009481 benzoate transport; Region: 2A0115; TIGR00895 745277009482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277009483 putative substrate translocation pore; other site 745277009484 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 745277009485 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 745277009486 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 745277009487 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745277009488 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 745277009489 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 745277009490 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 745277009491 H+ Antiporter protein; Region: 2A0121; TIGR00900 745277009492 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 745277009493 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 745277009494 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 745277009495 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 745277009496 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 745277009497 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 745277009498 NAD(P) binding site [chemical binding]; other site 745277009499 catalytic residues [active] 745277009500 Uncharacterized conserved protein [Function unknown]; Region: COG2850 745277009501 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 745277009502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277009503 dimer interface [polypeptide binding]; other site 745277009504 conserved gate region; other site 745277009505 putative PBP binding loops; other site 745277009506 ABC-ATPase subunit interface; other site 745277009507 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 745277009508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277009509 dimer interface [polypeptide binding]; other site 745277009510 conserved gate region; other site 745277009511 putative PBP binding loops; other site 745277009512 ABC-ATPase subunit interface; other site 745277009513 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 745277009514 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 745277009515 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 745277009516 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 745277009517 Walker A/P-loop; other site 745277009518 ATP binding site [chemical binding]; other site 745277009519 Q-loop/lid; other site 745277009520 ABC transporter signature motif; other site 745277009521 Walker B; other site 745277009522 D-loop; other site 745277009523 H-loop/switch region; other site 745277009524 D-lactate dehydrogenase; Provisional; Region: PRK11183 745277009525 FAD binding domain; Region: FAD_binding_4; cl19922 745277009526 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 745277009527 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 745277009528 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 745277009529 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 745277009530 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 745277009531 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 745277009532 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 745277009533 active site 745277009534 metal binding site [ion binding]; metal-binding site 745277009535 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 745277009536 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 745277009537 FMN binding site [chemical binding]; other site 745277009538 active site 745277009539 catalytic residues [active] 745277009540 substrate binding site [chemical binding]; other site 745277009541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277009542 Major Facilitator Superfamily; Region: MFS_1; pfam07690 745277009543 putative substrate translocation pore; other site 745277009544 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 745277009545 Predicted transcriptional regulator [Transcription]; Region: COG2345 745277009546 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 745277009547 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 745277009548 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 745277009549 ATP binding site [chemical binding]; other site 745277009550 Mg++ binding site [ion binding]; other site 745277009551 motif III; other site 745277009552 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 745277009553 nucleotide binding region [chemical binding]; other site 745277009554 ATP-binding site [chemical binding]; other site 745277009555 drug efflux system protein MdtG; Provisional; Region: PRK09874 745277009556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277009557 putative substrate translocation pore; other site 745277009558 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 745277009559 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 745277009560 MoaE homodimer interface [polypeptide binding]; other site 745277009561 MoaD interaction [polypeptide binding]; other site 745277009562 active site residues [active] 745277009563 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 745277009564 MoaE interaction surface [polypeptide binding]; other site 745277009565 MoeB interaction surface [polypeptide binding]; other site 745277009566 thiocarboxylated glycine; other site 745277009567 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 745277009568 trimer interface [polypeptide binding]; other site 745277009569 dimer interface [polypeptide binding]; other site 745277009570 putative active site [active] 745277009571 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 745277009572 MPT binding site; other site 745277009573 trimer interface [polypeptide binding]; other site 745277009574 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 745277009575 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 745277009576 FeS/SAM binding site; other site 745277009577 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 745277009578 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 745277009579 phosphate binding site [ion binding]; other site 745277009580 putative substrate binding pocket [chemical binding]; other site 745277009581 dimer interface [polypeptide binding]; other site 745277009582 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 745277009583 catalytic triad [active] 745277009584 conserved cis-peptide bond; other site 745277009585 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 745277009586 excinuclease ABC subunit B; Provisional; Region: PRK05298 745277009587 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 745277009588 ATP binding site [chemical binding]; other site 745277009589 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 745277009590 nucleotide binding region [chemical binding]; other site 745277009591 ATP-binding site [chemical binding]; other site 745277009592 Ultra-violet resistance protein B; Region: UvrB; pfam12344 745277009593 UvrB/uvrC motif; Region: UVR; pfam02151 745277009594 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 745277009595 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 745277009596 Walker A/P-loop; other site 745277009597 ATP binding site [chemical binding]; other site 745277009598 Q-loop/lid; other site 745277009599 ABC transporter signature motif; other site 745277009600 Walker B; other site 745277009601 D-loop; other site 745277009602 H-loop/switch region; other site 745277009603 AAA domain; Region: AAA_26; pfam13500 745277009604 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 745277009605 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 745277009606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277009607 S-adenosylmethionine binding site [chemical binding]; other site 745277009608 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 745277009609 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 745277009610 substrate-cofactor binding pocket; other site 745277009611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277009612 catalytic residue [active] 745277009613 biotin synthase; Provisional; Region: PRK15108 745277009614 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 745277009615 FeS/SAM binding site; other site 745277009616 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 745277009617 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 745277009618 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 745277009619 inhibitor-cofactor binding pocket; inhibition site 745277009620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277009621 catalytic residue [active] 745277009622 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 745277009623 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277009624 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 745277009625 dimerization interface [polypeptide binding]; other site 745277009626 substrate binding pocket [chemical binding]; other site 745277009627 methionine aminotransferase; Validated; Region: PRK09082 745277009628 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 745277009629 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277009630 homodimer interface [polypeptide binding]; other site 745277009631 catalytic residue [active] 745277009632 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 745277009633 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745277009634 substrate binding pocket [chemical binding]; other site 745277009635 membrane-bound complex binding site; other site 745277009636 hinge residues; other site 745277009637 PAAR motif; Region: PAAR_motif; pfam05488 745277009638 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 745277009639 Prostaglandin dehydrogenases; Region: PGDH; cd05288 745277009640 NAD(P) binding site [chemical binding]; other site 745277009641 substrate binding site [chemical binding]; other site 745277009642 dimer interface [polypeptide binding]; other site 745277009643 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 745277009644 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 745277009645 potential catalytic triad [active] 745277009646 conserved cys residue [active] 745277009647 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 745277009648 substrate binding site [chemical binding]; other site 745277009649 acyl-CoA thioesterase; Provisional; Region: PRK10531 745277009650 Pectinesterase; Region: Pectinesterase; cl01911 745277009651 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 745277009652 dimerization interface [polypeptide binding]; other site 745277009653 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 745277009654 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 745277009655 dimer interface [polypeptide binding]; other site 745277009656 putative CheW interface [polypeptide binding]; other site 745277009657 6-phosphogluconolactonase; Provisional; Region: PRK11028 745277009658 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 745277009659 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745277009660 active site 745277009661 motif I; other site 745277009662 motif II; other site 745277009663 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 745277009664 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 745277009665 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 745277009666 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745277009667 non-specific DNA binding site [nucleotide binding]; other site 745277009668 salt bridge; other site 745277009669 sequence-specific DNA binding site [nucleotide binding]; other site 745277009670 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 745277009671 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745277009672 Walker A/P-loop; other site 745277009673 ATP binding site [chemical binding]; other site 745277009674 Q-loop/lid; other site 745277009675 ABC transporter signature motif; other site 745277009676 Walker B; other site 745277009677 D-loop; other site 745277009678 H-loop/switch region; other site 745277009679 TOBE domain; Region: TOBE; pfam03459 745277009680 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 745277009681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277009682 dimer interface [polypeptide binding]; other site 745277009683 conserved gate region; other site 745277009684 putative PBP binding loops; other site 745277009685 ABC-ATPase subunit interface; other site 745277009686 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 745277009687 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 745277009688 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 745277009689 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 745277009690 molybdenum-pterin binding domain; Region: Mop; TIGR00638 745277009691 TOBE domain; Region: TOBE; cl01440 745277009692 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 745277009693 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745277009694 Walker A/P-loop; other site 745277009695 ATP binding site [chemical binding]; other site 745277009696 ABC transporter signature motif; other site 745277009697 Walker B; other site 745277009698 D-loop; other site 745277009699 H-loop/switch region; other site 745277009700 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745277009701 Walker A/P-loop; other site 745277009702 ATP binding site [chemical binding]; other site 745277009703 Q-loop/lid; other site 745277009704 ABC transporter signature motif; other site 745277009705 Walker B; other site 745277009706 D-loop; other site 745277009707 H-loop/switch region; other site 745277009708 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 745277009709 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277009710 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 745277009711 dimerization interface [polypeptide binding]; other site 745277009712 substrate binding pocket [chemical binding]; other site 745277009713 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 745277009714 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 745277009715 NAD binding site [chemical binding]; other site 745277009716 homodimer interface [polypeptide binding]; other site 745277009717 active site 745277009718 substrate binding site [chemical binding]; other site 745277009719 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 745277009720 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 745277009721 dimer interface [polypeptide binding]; other site 745277009722 active site 745277009723 galactokinase; Provisional; Region: PRK05101 745277009724 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 745277009725 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 745277009726 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 745277009727 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 745277009728 active site 745277009729 catalytic residues [active] 745277009730 psiF repeat; Region: PsiF_repeat; pfam07769 745277009731 psiF repeat; Region: PsiF_repeat; pfam07769 745277009732 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 745277009733 catalytic core [active] 745277009734 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 745277009735 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745277009736 Coenzyme A binding pocket [chemical binding]; other site 745277009737 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 745277009738 YbgS-like protein; Region: YbgS; pfam13985 745277009739 zinc transporter ZitB; Provisional; Region: PRK03557 745277009740 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 745277009741 quinolinate synthetase; Provisional; Region: PRK09375 745277009742 tol-pal system protein YbgF; Provisional; Region: PRK10803 745277009743 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 745277009744 binding surface 745277009745 TPR motif; other site 745277009746 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 745277009747 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 745277009748 ligand binding site [chemical binding]; other site 745277009749 translocation protein TolB; Provisional; Region: tolB; PRK03629 745277009750 TolB amino-terminal domain; Region: TolB_N; pfam04052 745277009751 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 745277009752 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 745277009753 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 745277009754 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 745277009755 TolA C-terminal; Region: TolA; pfam06519 745277009756 colicin uptake protein TolR; Provisional; Region: PRK11024 745277009757 colicin uptake protein TolQ; Provisional; Region: PRK10801 745277009758 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 745277009759 active site 745277009760 hypothetical protein; Provisional; Region: PRK10588 745277009761 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 745277009762 Cytochrome oxidase subunit II; Region: Cyto_ox_2; cl12219 745277009763 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 745277009764 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 745277009765 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 745277009766 CoA binding domain; Region: CoA_binding; pfam02629 745277009767 CoA-ligase; Region: Ligase_CoA; pfam00549 745277009768 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 745277009769 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 745277009770 CoA-ligase; Region: Ligase_CoA; pfam00549 745277009771 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 745277009772 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 745277009773 E3 interaction surface; other site 745277009774 lipoyl attachment site [posttranslational modification]; other site 745277009775 e3 binding domain; Region: E3_binding; pfam02817 745277009776 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 745277009777 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 745277009778 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 745277009779 TPP-binding site [chemical binding]; other site 745277009780 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 745277009781 dimer interface [polypeptide binding]; other site 745277009782 PYR/PP interface [polypeptide binding]; other site 745277009783 TPP binding site [chemical binding]; other site 745277009784 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 745277009785 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 745277009786 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 745277009787 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 745277009788 L-aspartate oxidase; Provisional; Region: PRK06175 745277009789 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 745277009790 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 745277009791 SdhC subunit interface [polypeptide binding]; other site 745277009792 proximal heme binding site [chemical binding]; other site 745277009793 cardiolipin binding site; other site 745277009794 Iron-sulfur protein interface; other site 745277009795 proximal quinone binding site [chemical binding]; other site 745277009796 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 745277009797 Iron-sulfur protein interface; other site 745277009798 proximal quinone binding site [chemical binding]; other site 745277009799 SdhD (CybS) interface [polypeptide binding]; other site 745277009800 proximal heme binding site [chemical binding]; other site 745277009801 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 745277009802 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 745277009803 dimer interface [polypeptide binding]; other site 745277009804 active site 745277009805 citrylCoA binding site [chemical binding]; other site 745277009806 NADH binding [chemical binding]; other site 745277009807 cationic pore residues; other site 745277009808 oxalacetate/citrate binding site [chemical binding]; other site 745277009809 coenzyme A binding site [chemical binding]; other site 745277009810 catalytic triad [active] 745277009811 endonuclease VIII; Provisional; Region: PRK10445 745277009812 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 745277009813 DNA binding site [nucleotide binding] 745277009814 catalytic residue [active] 745277009815 H2TH interface [polypeptide binding]; other site 745277009816 putative catalytic residues [active] 745277009817 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 745277009818 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 745277009819 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 745277009820 putative substrate binding pocket [chemical binding]; other site 745277009821 AC domain interface; other site 745277009822 catalytic triad [active] 745277009823 AB domain interface; other site 745277009824 interchain disulfide; other site 745277009825 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 745277009826 putative active site [active] 745277009827 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 745277009828 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 745277009829 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277009830 putative substrate translocation pore; other site 745277009831 Major Facilitator Superfamily; Region: MFS_1; pfam07690 745277009832 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 745277009833 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 745277009834 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 745277009835 DNA photolyase; Region: DNA_photolyase; pfam00875 745277009836 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 745277009837 Protein of unknown function (DUF523); Region: DUF523; pfam04463 745277009838 Uncharacterized conserved protein [Function unknown]; Region: COG3272 745277009839 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 745277009840 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 745277009841 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 745277009842 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 745277009843 Soluble P-type ATPase [General function prediction only]; Region: COG4087 745277009844 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 745277009845 sensor protein KdpD; Provisional; Region: PRK10490 745277009846 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 745277009847 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 745277009848 Ligand Binding Site [chemical binding]; other site 745277009849 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 745277009850 GAF domain; Region: GAF_3; pfam13492 745277009851 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745277009852 dimer interface [polypeptide binding]; other site 745277009853 phosphorylation site [posttranslational modification] 745277009854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277009855 ATP binding site [chemical binding]; other site 745277009856 Mg2+ binding site [ion binding]; other site 745277009857 G-X-G motif; other site 745277009858 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 745277009859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277009860 active site 745277009861 phosphorylation site [posttranslational modification] 745277009862 intermolecular recognition site; other site 745277009863 dimerization interface [polypeptide binding]; other site 745277009864 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 745277009865 DNA binding site [nucleotide binding] 745277009866 Predicted transcriptional regulators [Transcription]; Region: COG1695 745277009867 phosphoglucomutase; Validated; Region: PRK07564 745277009868 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 745277009869 active site 745277009870 substrate binding site [chemical binding]; other site 745277009871 metal binding site [ion binding]; metal-binding site 745277009872 replication initiation regulator SeqA; Provisional; Region: PRK11187 745277009873 Putative lysophospholipase; Region: Hydrolase_4; cl19140 745277009874 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 745277009875 LexA regulated protein; Provisional; Region: PRK11675 745277009876 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 745277009877 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 745277009878 dimer interface [polypeptide binding]; other site 745277009879 ligand binding site [chemical binding]; other site 745277009880 HAMP domain; Region: HAMP; pfam00672 745277009881 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 745277009882 dimer interface [polypeptide binding]; other site 745277009883 putative CheW interface [polypeptide binding]; other site 745277009884 flavodoxin FldA; Validated; Region: PRK09267 745277009885 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 745277009886 metal binding site 2 [ion binding]; metal-binding site 745277009887 putative DNA binding helix; other site 745277009888 metal binding site 1 [ion binding]; metal-binding site 745277009889 dimer interface [polypeptide binding]; other site 745277009890 structural Zn2+ binding site [ion binding]; other site 745277009891 YbfN-like lipoprotein; Region: YbfN; pfam13982 745277009892 outer membrane porin, OprD family; Region: OprD; pfam03573 745277009893 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 745277009894 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 745277009895 active site 745277009896 HIGH motif; other site 745277009897 KMSKS motif; other site 745277009898 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 745277009899 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 745277009900 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 745277009901 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 745277009902 active site turn [active] 745277009903 phosphorylation site [posttranslational modification] 745277009904 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 745277009905 HPr interaction site; other site 745277009906 glycerol kinase (GK) interaction site [polypeptide binding]; other site 745277009907 active site 745277009908 phosphorylation site [posttranslational modification] 745277009909 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 745277009910 active site 745277009911 trimer interface [polypeptide binding]; other site 745277009912 allosteric site; other site 745277009913 active site lid [active] 745277009914 hexamer (dimer of trimers) interface [polypeptide binding]; other site 745277009915 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 745277009916 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 745277009917 active site 745277009918 dimer interface [polypeptide binding]; other site 745277009919 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 745277009920 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 745277009921 ROK family; Region: ROK; pfam00480 745277009922 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 745277009923 UMP phosphatase; Provisional; Region: PRK10444 745277009924 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745277009925 active site 745277009926 motif I; other site 745277009927 motif II; other site 745277009928 asparagine synthetase B; Provisional; Region: asnB; PRK09431 745277009929 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 745277009930 active site 745277009931 dimer interface [polypeptide binding]; other site 745277009932 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 745277009933 Ligand Binding Site [chemical binding]; other site 745277009934 Molecular Tunnel; other site 745277009935 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 745277009936 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 745277009937 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 745277009938 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 745277009939 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 745277009940 FeS/SAM binding site; other site 745277009941 TRAM domain; Region: TRAM; pfam01938 745277009942 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 745277009943 PhoH-like protein; Region: PhoH; pfam02562 745277009944 metal-binding heat shock protein; Provisional; Region: PRK00016 745277009945 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 745277009946 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 745277009947 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 745277009948 Transporter associated domain; Region: CorC_HlyC; smart01091 745277009949 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 745277009950 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 745277009951 putative active site [active] 745277009952 catalytic triad [active] 745277009953 putative dimer interface [polypeptide binding]; other site 745277009954 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 745277009955 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745277009956 substrate binding pocket [chemical binding]; other site 745277009957 membrane-bound complex binding site; other site 745277009958 hinge residues; other site 745277009959 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 745277009960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277009961 dimer interface [polypeptide binding]; other site 745277009962 conserved gate region; other site 745277009963 putative PBP binding loops; other site 745277009964 ABC-ATPase subunit interface; other site 745277009965 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 745277009966 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277009967 dimer interface [polypeptide binding]; other site 745277009968 conserved gate region; other site 745277009969 putative PBP binding loops; other site 745277009970 ABC-ATPase subunit interface; other site 745277009971 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 745277009972 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 745277009973 Walker A/P-loop; other site 745277009974 ATP binding site [chemical binding]; other site 745277009975 Q-loop/lid; other site 745277009976 ABC transporter signature motif; other site 745277009977 Walker B; other site 745277009978 D-loop; other site 745277009979 H-loop/switch region; other site 745277009980 hypothetical protein; Provisional; Region: PRK11032 745277009981 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 745277009982 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 745277009983 active site 745277009984 HIGH motif; other site 745277009985 KMSKS motif; other site 745277009986 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 745277009987 tRNA binding surface [nucleotide binding]; other site 745277009988 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 745277009989 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 745277009990 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 745277009991 Processivity clamp loader gamma complex DNA pol III C-term; Region: DNA_pol3_delt_C; pfam14840 745277009992 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 745277009993 active site 745277009994 (T/H)XGH motif; other site 745277009995 Oligomerization domain; Region: Oligomerization; cl00519 745277009996 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 745277009997 penicillin-binding protein 2; Provisional; Region: PRK10795 745277009998 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 745277009999 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 745277010000 cell wall shape-determining protein; Provisional; Region: PRK10794 745277010001 rare lipoprotein A; Provisional; Region: PRK10672 745277010002 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 745277010003 Sporulation related domain; Region: SPOR; pfam05036 745277010004 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 745277010005 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 745277010006 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 745277010007 hypothetical protein; Provisional; Region: PRK04998 745277010008 lipoate-protein ligase B; Provisional; Region: PRK14342 745277010009 lipoyl synthase; Provisional; Region: PRK05481 745277010010 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 745277010011 FeS/SAM binding site; other site 745277010012 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 745277010013 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 745277010014 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 745277010015 Walker A/P-loop; other site 745277010016 ATP binding site [chemical binding]; other site 745277010017 Q-loop/lid; other site 745277010018 ABC transporter signature motif; other site 745277010019 Walker B; other site 745277010020 D-loop; other site 745277010021 H-loop/switch region; other site 745277010022 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 745277010023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277010024 dimer interface [polypeptide binding]; other site 745277010025 conserved gate region; other site 745277010026 putative PBP binding loops; other site 745277010027 ABC-ATPase subunit interface; other site 745277010028 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745277010029 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 745277010030 substrate binding pocket [chemical binding]; other site 745277010031 membrane-bound complex binding site; other site 745277010032 hinge residues; other site 745277010033 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 745277010034 putative active site [active] 745277010035 catalytic triad [active] 745277010036 putative dimer interface [polypeptide binding]; other site 745277010037 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 745277010038 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 745277010039 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 745277010040 DNA-binding site [nucleotide binding]; DNA binding site 745277010041 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 745277010042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277010043 homodimer interface [polypeptide binding]; other site 745277010044 catalytic residue [active] 745277010045 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 745277010046 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745277010047 Coenzyme A binding pocket [chemical binding]; other site 745277010048 chromosome condensation membrane protein; Provisional; Region: PRK14196 745277010049 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 745277010050 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745277010051 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 745277010052 DNA-binding site [nucleotide binding]; DNA binding site 745277010053 RNA-binding motif; other site 745277010054 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 745277010055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3416 745277010056 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 745277010057 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 745277010058 intersubunit interface [polypeptide binding]; other site 745277010059 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 745277010060 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 745277010061 anti-adapter protein IraM; Provisional; Region: PRK09919 745277010062 Cupin domain; Region: Cupin_2; cl17218 745277010063 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 745277010064 MASE2 domain; Region: MASE2; pfam05230 745277010065 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745277010066 metal binding site [ion binding]; metal-binding site 745277010067 active site 745277010068 I-site; other site 745277010069 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 745277010070 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277010071 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277010072 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 745277010073 putative effector binding pocket; other site 745277010074 putative dimerization interface [polypeptide binding]; other site 745277010075 maltose O-acetyltransferase; Provisional; Region: PRK10092 745277010076 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 745277010077 active site 745277010078 substrate binding site [chemical binding]; other site 745277010079 trimer interface [polypeptide binding]; other site 745277010080 CoA binding site [chemical binding]; other site 745277010081 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 745277010082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277010083 putative substrate translocation pore; other site 745277010084 TIGR02453 family protein; Region: TIGR02453 745277010085 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 745277010086 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 745277010087 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 745277010088 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 745277010089 homodimer interface [polypeptide binding]; other site 745277010090 NADP binding site [chemical binding]; other site 745277010091 substrate binding site [chemical binding]; other site 745277010092 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 745277010093 RNA binding surface [nucleotide binding]; other site 745277010094 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 745277010095 Autotransporter beta-domain; Region: Autotransporter; smart00869 745277010096 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 745277010097 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 745277010098 dimer interface [polypeptide binding]; other site 745277010099 ADP-ribose binding site [chemical binding]; other site 745277010100 active site 745277010101 nudix motif; other site 745277010102 metal binding site [ion binding]; metal-binding site 745277010103 Winged helix-turn helix; Region: HTH_43; pfam09904 745277010104 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 745277010105 MMPL family; Region: MMPL; cl14618 745277010106 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 745277010107 putative catalytic residues [active] 745277010108 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 745277010109 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 745277010110 metal binding site [ion binding]; metal-binding site 745277010111 dimer interface [polypeptide binding]; other site 745277010112 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 745277010113 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 745277010114 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 745277010115 Uncharacterized protein family (UPF0370); Region: UPF0370; pfam13980 745277010116 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 745277010117 ATP-grasp domain; Region: ATP-grasp_4; cl17255 745277010118 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 745277010119 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 745277010120 catalytic residue [active] 745277010121 putative hydrolase; Provisional; Region: PRK11460 745277010122 Predicted esterase [General function prediction only]; Region: COG0400 745277010123 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 745277010124 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 745277010125 Helicase; Region: Helicase_RecD; pfam05127 745277010126 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745277010127 Coenzyme A binding pocket [chemical binding]; other site 745277010128 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 745277010129 Predicted membrane protein [Function unknown]; Region: COG2707 745277010130 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 745277010131 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 745277010132 ATP binding site [chemical binding]; other site 745277010133 active site 745277010134 substrate binding site [chemical binding]; other site 745277010135 lipoprotein; Provisional; Region: PRK11679 745277010136 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 745277010137 dimer interface [polypeptide binding]; other site 745277010138 active site 745277010139 catalytic residue [active] 745277010140 Protein of unknown function (DUF3121); Region: DUF3121; cl11879 745277010141 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 745277010142 tail protein; Provisional; Region: D; PHA02561 745277010143 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 745277010144 Phage tail tube protein FII; Region: Phage_tube; pfam04985 745277010145 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 745277010146 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 745277010147 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 745277010148 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 745277010149 Phage protein U [General function prediction only]; Region: COG3499 745277010150 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 745277010151 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 745277010152 Phage Tail Collar Domain; Region: Collar; pfam07484 745277010153 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 745277010154 baseplate assembly protein; Provisional; Region: J; PHA02568 745277010155 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 745277010156 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 745277010157 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 745277010158 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 745277010159 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 745277010160 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 745277010161 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 745277010162 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 745277010163 Phage Tail Protein X; Region: Phage_tail_X; cl02088 745277010164 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 745277010165 Phage small terminase subunit; Region: Phage_term_smal; cl19614 745277010166 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 745277010167 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 745277010168 terminase ATPase subunit; Provisional; Region: P; PHA02535 745277010169 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 745277010170 Phage Terminase; Region: Terminase_1; cl19862 745277010171 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 745277010172 Phage portal protein; Region: Phage_portal; cl19194 745277010173 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 745277010174 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 745277010175 cofactor binding site; other site 745277010176 DNA binding site [nucleotide binding] 745277010177 substrate interaction site [chemical binding]; other site 745277010178 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 745277010179 Protein of unknown function (DUF2724); Region: DUF2724; pfam10893 745277010180 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745277010181 non-specific DNA binding site [nucleotide binding]; other site 745277010182 salt bridge; other site 745277010183 sequence-specific DNA binding site [nucleotide binding]; other site 745277010184 integrase; Provisional; Region: int; PHA02601 745277010185 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 745277010186 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 745277010187 active site 745277010188 DNA binding site [nucleotide binding] 745277010189 Int/Topo IB signature motif; other site 745277010190 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 745277010191 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 745277010192 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 745277010193 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 745277010194 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 745277010195 catalytic triad [active] 745277010196 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 745277010197 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 745277010198 Peptidase family M48; Region: Peptidase_M48; cl12018 745277010199 Glutamate-cysteine ligase; Region: GCS; pfam03074 745277010200 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 745277010201 catalytic residues [active] 745277010202 DNA replication initiation factor; Provisional; Region: PRK08084 745277010203 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 745277010204 uracil transporter; Provisional; Region: PRK10720 745277010205 uracil-xanthine permease; Region: ncs2; TIGR00801 745277010206 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 745277010207 active site 745277010208 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 745277010209 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 745277010210 dimerization interface [polypeptide binding]; other site 745277010211 putative ATP binding site [chemical binding]; other site 745277010212 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 745277010213 active site 745277010214 substrate binding site [chemical binding]; other site 745277010215 cosubstrate binding site; other site 745277010216 catalytic site [active] 745277010217 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 745277010218 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745277010219 Coenzyme A binding pocket [chemical binding]; other site 745277010220 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 745277010221 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 745277010222 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 745277010223 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 745277010224 putative active site [active] 745277010225 catalytic site [active] 745277010226 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 745277010227 domain interface [polypeptide binding]; other site 745277010228 active site 745277010229 catalytic site [active] 745277010230 exopolyphosphatase; Provisional; Region: PRK10854 745277010231 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 745277010232 nucleotide binding site [chemical binding]; other site 745277010233 MASE1; Region: MASE1; cl17823 745277010234 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 745277010235 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 745277010236 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 745277010237 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 745277010238 MgtE intracellular N domain; Region: MgtE_N; smart00924 745277010239 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 745277010240 Divalent cation transporter; Region: MgtE; cl00786 745277010241 MASE1; Region: MASE1; cl17823 745277010242 PAS domain S-box; Region: sensory_box; TIGR00229 745277010243 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 745277010244 putative active site [active] 745277010245 heme pocket [chemical binding]; other site 745277010246 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 745277010247 PAS domain; Region: PAS_9; pfam13426 745277010248 putative active site [active] 745277010249 heme pocket [chemical binding]; other site 745277010250 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745277010251 metal binding site [ion binding]; metal-binding site 745277010252 active site 745277010253 I-site; other site 745277010254 AlkA N-terminal domain; Region: AlkA_N; pfam06029 745277010255 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 745277010256 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 745277010257 minor groove reading motif; other site 745277010258 helix-hairpin-helix signature motif; other site 745277010259 substrate binding pocket [chemical binding]; other site 745277010260 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 745277010261 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 745277010262 active site 745277010263 HIGH motif; other site 745277010264 KMSKS motif; other site 745277010265 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 745277010266 tRNA binding surface [nucleotide binding]; other site 745277010267 anticodon binding site; other site 745277010268 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 745277010269 substrate binding site [chemical binding]; other site 745277010270 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 745277010271 putative active site [active] 745277010272 putative metal binding site [ion binding]; other site 745277010273 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 745277010274 active site 745277010275 dinuclear metal binding site [ion binding]; other site 745277010276 dimerization interface [polypeptide binding]; other site 745277010277 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 745277010278 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 745277010279 ATP-grasp domain; Region: ATP-grasp; pfam02222 745277010280 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 745277010281 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 745277010282 FtsX-like permease family; Region: FtsX; pfam02687 745277010283 FtsX-like permease family; Region: FtsX; pfam02687 745277010284 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 745277010285 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 745277010286 Walker A/P-loop; other site 745277010287 ATP binding site [chemical binding]; other site 745277010288 Q-loop/lid; other site 745277010289 ABC transporter signature motif; other site 745277010290 Walker B; other site 745277010291 D-loop; other site 745277010292 H-loop/switch region; other site 745277010293 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 745277010294 active site 745277010295 catalytic triad [active] 745277010296 oxyanion hole [active] 745277010297 switch loop; other site 745277010298 short chain dehydrogenase; Validated; Region: PRK06182 745277010299 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 745277010300 NADP binding site [chemical binding]; other site 745277010301 active site 745277010302 steroid binding site; other site 745277010303 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 745277010304 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 745277010305 Tetratricopeptide repeat; Region: TPR_20; pfam14561 745277010306 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 745277010307 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 745277010308 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 745277010309 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 745277010310 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 745277010311 DNA binding residues [nucleotide binding] 745277010312 dimer interface [polypeptide binding]; other site 745277010313 copper binding site [ion binding]; other site 745277010314 copper exporting ATPase; Provisional; Region: copA; PRK10671 745277010315 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 745277010316 metal-binding site [ion binding] 745277010317 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 745277010318 metal-binding site [ion binding] 745277010319 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 745277010320 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745277010321 motif II; other site 745277010322 TraB family; Region: TraB; cl12050 745277010323 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 745277010324 putative deacylase active site [active] 745277010325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277010326 Major Facilitator Superfamily; Region: MFS_1; pfam07690 745277010327 putative substrate translocation pore; other site 745277010328 putative cation:proton antiport protein; Provisional; Region: PRK10669 745277010329 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 745277010330 TrkA-N domain; Region: TrkA_N; pfam02254 745277010331 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 745277010332 inosine/guanosine kinase; Provisional; Region: PRK15074 745277010333 substrate binding site [chemical binding]; other site 745277010334 ATP binding site [chemical binding]; other site 745277010335 ferrochelatase; Reviewed; Region: hemH; PRK00035 745277010336 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 745277010337 C-terminal domain interface [polypeptide binding]; other site 745277010338 active site 745277010339 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 745277010340 active site 745277010341 N-terminal domain interface [polypeptide binding]; other site 745277010342 adenylate kinase; Reviewed; Region: adk; PRK00279 745277010343 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 745277010344 AMP-binding site [chemical binding]; other site 745277010345 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 745277010346 heat shock protein 90; Provisional; Region: PRK05218 745277010347 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277010348 ATP binding site [chemical binding]; other site 745277010349 Mg2+ binding site [ion binding]; other site 745277010350 G-X-G motif; other site 745277010351 Hsp90 protein; Region: HSP90; pfam00183 745277010352 recombination protein RecR; Reviewed; Region: recR; PRK00076 745277010353 RecR protein; Region: RecR; pfam02132 745277010354 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 745277010355 putative active site [active] 745277010356 putative metal-binding site [ion binding]; other site 745277010357 tetramer interface [polypeptide binding]; other site 745277010358 hypothetical protein; Validated; Region: PRK00153 745277010359 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 745277010360 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745277010361 Walker A motif; other site 745277010362 ATP binding site [chemical binding]; other site 745277010363 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 745277010364 Walker B motif; other site 745277010365 arginine finger; other site 745277010366 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 745277010367 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 745277010368 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 745277010369 alpha-amylase; Reviewed; Region: malS; PRK09505 745277010370 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 745277010371 active site 745277010372 catalytic site [active] 745277010373 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 745277010374 active site 745277010375 hypothetical protein; Provisional; Region: PRK10527 745277010376 Primosomal replication protein priB and priC; Region: priB_priC; pfam07445 745277010377 hypothetical protein; Provisional; Region: PRK11038 745277010378 hypothetical protein; Provisional; Region: PRK11281 745277010379 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 745277010380 Mechanosensitive ion channel; Region: MS_channel; pfam00924 745277010381 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 745277010382 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745277010383 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 745277010384 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 745277010385 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 745277010386 HlyD family secretion protein; Region: HlyD_3; pfam13437 745277010387 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 745277010388 MMPL family; Region: MMPL; cl14618 745277010389 MMPL family; Region: MMPL; cl14618 745277010390 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 745277010391 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 745277010392 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 745277010393 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 745277010394 metal binding site [ion binding]; metal-binding site 745277010395 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 745277010396 ABC-ATPase subunit interface; other site 745277010397 dimer interface [polypeptide binding]; other site 745277010398 putative PBP binding regions; other site 745277010399 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 745277010400 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 745277010401 Hha toxicity attenuator; Provisional; Region: PRK10667 745277010402 gene expression modulator; Provisional; Region: PRK10945 745277010403 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277010404 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277010405 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 745277010406 dimerization interface [polypeptide binding]; other site 745277010407 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 745277010408 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 745277010409 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 745277010410 active site 745277010411 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 745277010412 Sulfate transporter family; Region: Sulfate_transp; cl19250 745277010413 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 745277010414 DNA binding site [nucleotide binding] 745277010415 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 745277010416 active site 745277010417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 745277010418 acyl-CoA thioesterase II; Provisional; Region: PRK10526 745277010419 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 745277010420 active site 745277010421 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 745277010422 catalytic triad [active] 745277010423 dimer interface [polypeptide binding]; other site 745277010424 ammonium transporter; Provisional; Region: PRK10666 745277010425 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 745277010426 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 745277010427 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 745277010428 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745277010429 Walker A/P-loop; other site 745277010430 ATP binding site [chemical binding]; other site 745277010431 Q-loop/lid; other site 745277010432 ABC transporter signature motif; other site 745277010433 Walker B; other site 745277010434 D-loop; other site 745277010435 H-loop/switch region; other site 745277010436 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 745277010437 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 745277010438 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745277010439 Walker A/P-loop; other site 745277010440 ATP binding site [chemical binding]; other site 745277010441 Q-loop/lid; other site 745277010442 ABC transporter signature motif; other site 745277010443 Walker B; other site 745277010444 D-loop; other site 745277010445 H-loop/switch region; other site 745277010446 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 745277010447 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 745277010448 putative DNA binding site [nucleotide binding]; other site 745277010449 putative Zn2+ binding site [ion binding]; other site 745277010450 AsnC family; Region: AsnC_trans_reg; pfam01037 745277010451 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 745277010452 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 745277010453 catalytic residue [active] 745277010454 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 745277010455 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745277010456 active site 745277010457 motif I; other site 745277010458 motif II; other site 745277010459 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 745277010460 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 745277010461 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 745277010462 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 745277010463 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 745277010464 Ligand Binding Site [chemical binding]; other site 745277010465 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 745277010466 active site 745277010467 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 745277010468 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 745277010469 periplasmic folding chaperone; Provisional; Region: PRK10788 745277010470 SurA N-terminal domain; Region: SurA_N_3; cl07813 745277010471 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 745277010472 histone-like DNA-binding protein HU; Region: HU; cd13831 745277010473 dimer interface [polypeptide binding]; other site 745277010474 DNA binding site [nucleotide binding] 745277010475 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 745277010476 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 745277010477 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745277010478 Walker A motif; other site 745277010479 ATP binding site [chemical binding]; other site 745277010480 Walker B motif; other site 745277010481 arginine finger; other site 745277010482 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 745277010483 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 745277010484 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 745277010485 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745277010486 Walker A motif; other site 745277010487 ATP binding site [chemical binding]; other site 745277010488 Walker B motif; other site 745277010489 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 745277010490 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 745277010491 oligomer interface [polypeptide binding]; other site 745277010492 active site residues [active] 745277010493 trigger factor; Provisional; Region: tig; PRK01490 745277010494 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 745277010495 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 745277010496 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 745277010497 transcriptional regulator BolA; Provisional; Region: PRK11628 745277010498 hypothetical protein; Provisional; Region: PRK11627 745277010499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277010500 Major Facilitator Superfamily; Region: MFS_1; pfam07690 745277010501 putative substrate translocation pore; other site 745277010502 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 745277010503 The cupredoxin domain of Ubiquinol oxidase subunit II; Region: CuRO_UO_II; cd04212 745277010504 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 745277010505 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 745277010506 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 745277010507 D-pathway; other site 745277010508 Putative ubiquinol binding site [chemical binding]; other site 745277010509 Low-spin heme (heme b) binding site [chemical binding]; other site 745277010510 Putative water exit pathway; other site 745277010511 Binuclear center (heme o3/CuB) [ion binding]; other site 745277010512 K-pathway; other site 745277010513 Putative proton exit pathway; other site 745277010514 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 745277010515 Subunit I/III interface [polypeptide binding]; other site 745277010516 Subunit III/IV interface [polypeptide binding]; other site 745277010517 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 745277010518 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 745277010519 putative active site [active] 745277010520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277010521 Major Facilitator Superfamily; Region: MFS_1; pfam07690 745277010522 putative substrate translocation pore; other site 745277010523 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 745277010524 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 745277010525 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 745277010526 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 745277010527 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 745277010528 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 745277010529 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 745277010530 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 745277010531 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 745277010532 conserved cys residue [active] 745277010533 Transposase IS200 like; Region: Y1_Tnp; pfam01797 745277010534 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 745277010535 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 745277010536 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 745277010537 Ligand Binding Site [chemical binding]; other site 745277010538 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 745277010539 active site residue [active] 745277010540 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 745277010541 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 745277010542 substrate binding pocket [chemical binding]; other site 745277010543 chain length determination region; other site 745277010544 active site lid residues [active] 745277010545 substrate-Mg2+ binding site; other site 745277010546 catalytic residues [active] 745277010547 aspartate-rich region 1; other site 745277010548 aspartate-rich region 2; other site 745277010549 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 745277010550 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 745277010551 TPP-binding site; other site 745277010552 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 745277010553 PYR/PP interface [polypeptide binding]; other site 745277010554 dimer interface [polypeptide binding]; other site 745277010555 TPP binding site [chemical binding]; other site 745277010556 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 745277010557 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 745277010558 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 745277010559 active site 745277010560 catalytic tetrad [active] 745277010561 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 745277010562 tetramer interfaces [polypeptide binding]; other site 745277010563 binuclear metal-binding site [ion binding]; other site 745277010564 thiamine monophosphate kinase; Provisional; Region: PRK05731 745277010565 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 745277010566 ATP binding site [chemical binding]; other site 745277010567 dimerization interface [polypeptide binding]; other site 745277010568 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 745277010569 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 745277010570 homopentamer interface [polypeptide binding]; other site 745277010571 active site 745277010572 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 745277010573 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 745277010574 catalytic motif [active] 745277010575 Zn binding site [ion binding]; other site 745277010576 RibD C-terminal domain; Region: RibD_C; cl17279 745277010577 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 745277010578 ATP cone domain; Region: ATP-cone; pfam03477 745277010579 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 745277010580 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 745277010581 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 745277010582 Protein export membrane protein; Region: SecD_SecF; pfam02355 745277010583 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 745277010584 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 745277010585 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 745277010586 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 745277010587 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 745277010588 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 745277010589 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 745277010590 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 745277010591 Protein of unknown function, DUF479; Region: DUF479; cl01203 745277010592 peroxidase; Provisional; Region: PRK15000 745277010593 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 745277010594 dimer interface [polypeptide binding]; other site 745277010595 decamer (pentamer of dimers) interface [polypeptide binding]; other site 745277010596 catalytic triad [active] 745277010597 peroxidatic and resolving cysteines [active] 745277010598 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 745277010599 putative proline-specific permease; Provisional; Region: proY; PRK10580 745277010600 Spore germination protein; Region: Spore_permease; cl17796 745277010601 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 745277010602 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 745277010603 substrate binding site [chemical binding]; other site 745277010604 THF binding site; other site 745277010605 zinc-binding site [ion binding]; other site 745277010606 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 745277010607 Predicted transcriptional regulator [Transcription]; Region: COG2944 745277010608 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745277010609 non-specific DNA binding site [nucleotide binding]; other site 745277010610 salt bridge; other site 745277010611 sequence-specific DNA binding site [nucleotide binding]; other site 745277010612 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 745277010613 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 745277010614 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 745277010615 putative active site [active] 745277010616 heme pocket [chemical binding]; other site 745277010617 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745277010618 dimer interface [polypeptide binding]; other site 745277010619 phosphorylation site [posttranslational modification] 745277010620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277010621 ATP binding site [chemical binding]; other site 745277010622 Mg2+ binding site [ion binding]; other site 745277010623 G-X-G motif; other site 745277010624 transcriptional regulator PhoB; Provisional; Region: PRK10161 745277010625 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277010626 active site 745277010627 phosphorylation site [posttranslational modification] 745277010628 intermolecular recognition site; other site 745277010629 dimerization interface [polypeptide binding]; other site 745277010630 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 745277010631 DNA binding site [nucleotide binding] 745277010632 exonuclease subunit SbcD; Provisional; Region: PRK10966 745277010633 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 745277010634 active site 745277010635 metal binding site [ion binding]; metal-binding site 745277010636 DNA binding site [nucleotide binding] 745277010637 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 745277010638 exonuclease subunit SbcC; Provisional; Region: PRK10246 745277010639 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745277010640 Walker A/P-loop; other site 745277010641 ATP binding site [chemical binding]; other site 745277010642 Q-loop/lid; other site 745277010643 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 745277010644 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745277010645 ABC transporter signature motif; other site 745277010646 Walker B; other site 745277010647 D-loop; other site 745277010648 H-loop/switch region; other site 745277010649 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 745277010650 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 745277010651 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 745277010652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277010653 dimer interface [polypeptide binding]; other site 745277010654 conserved gate region; other site 745277010655 putative PBP binding loops; other site 745277010656 ABC-ATPase subunit interface; other site 745277010657 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 745277010658 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 745277010659 Walker A/P-loop; other site 745277010660 ATP binding site [chemical binding]; other site 745277010661 Q-loop/lid; other site 745277010662 ABC transporter signature motif; other site 745277010663 Walker B; other site 745277010664 D-loop; other site 745277010665 H-loop/switch region; other site 745277010666 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 745277010667 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 745277010668 nucleotide binding site [chemical binding]; other site 745277010669 recombination associated protein; Reviewed; Region: rdgC; PRK00321 745277010670 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 745277010671 hypothetical protein; Provisional; Region: PRK10481 745277010672 Protein of unknown function (DUF1177); Region: DUF1177; pfam06675 745277010673 OPT oligopeptide transporter protein; Region: OPT; cl14607 745277010674 Transcriptional regulator [Transcription]; Region: IclR; COG1414 745277010675 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 745277010676 putative DNA binding site [nucleotide binding]; other site 745277010677 putative Zn2+ binding site [ion binding]; other site 745277010678 Bacterial transcriptional regulator; Region: IclR; pfam01614 745277010679 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 745277010680 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 745277010681 ADP binding site [chemical binding]; other site 745277010682 magnesium binding site [ion binding]; other site 745277010683 putative shikimate binding site; other site 745277010684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 745277010685 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 745277010686 Protein of unknown function (DUF808); Region: DUF808; pfam05661 745277010687 Methyltransferase domain; Region: Methyltransf_31; pfam13847 745277010688 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277010689 S-adenosylmethionine binding site [chemical binding]; other site 745277010690 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745277010691 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 745277010692 salt bridge; other site 745277010693 non-specific DNA binding site [nucleotide binding]; other site 745277010694 sequence-specific DNA binding site [nucleotide binding]; other site 745277010695 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 745277010696 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 745277010697 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 745277010698 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 745277010699 active site residue [active] 745277010700 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 745277010701 active site residue [active] 745277010702 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 745277010703 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 745277010704 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 745277010705 putative di-iron ligands [ion binding]; other site 745277010706 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 745277010707 catalytic core [active] 745277010708 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 745277010709 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 745277010710 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 745277010711 dimerization interface [polypeptide binding]; other site 745277010712 ATP binding site [chemical binding]; other site 745277010713 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 745277010714 dimerization interface [polypeptide binding]; other site 745277010715 ATP binding site [chemical binding]; other site 745277010716 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 745277010717 putative active site [active] 745277010718 catalytic triad [active] 745277010719 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 745277010720 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745277010721 substrate binding pocket [chemical binding]; other site 745277010722 membrane-bound complex binding site; other site 745277010723 hinge residues; other site 745277010724 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 745277010725 N-acetyl-D-glucosamine binding site [chemical binding]; other site 745277010726 catalytic residue [active] 745277010727 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 745277010728 nucleoside/Zn binding site; other site 745277010729 dimer interface [polypeptide binding]; other site 745277010730 catalytic motif [active] 745277010731 hypothetical protein; Provisional; Region: PRK11590 745277010732 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 745277010733 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 745277010734 active site turn [active] 745277010735 phosphorylation site [posttranslational modification] 745277010736 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 745277010737 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 745277010738 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 745277010739 putative active site [active] 745277010740 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 745277010741 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 745277010742 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 745277010743 putative active site [active] 745277010744 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 745277010745 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 745277010746 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 745277010747 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 745277010748 active site 745277010749 hydrophilic channel; other site 745277010750 dimerization interface [polypeptide binding]; other site 745277010751 catalytic residues [active] 745277010752 active site lid [active] 745277010753 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 745277010754 Recombination protein O N terminal; Region: RecO_N; pfam11967 745277010755 Recombination protein O C terminal; Region: RecO_C; pfam02565 745277010756 GTPase Era; Reviewed; Region: era; PRK00089 745277010757 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 745277010758 G1 box; other site 745277010759 GTP/Mg2+ binding site [chemical binding]; other site 745277010760 Switch I region; other site 745277010761 G2 box; other site 745277010762 Switch II region; other site 745277010763 G3 box; other site 745277010764 G4 box; other site 745277010765 G5 box; other site 745277010766 KH domain; Region: KH_2; pfam07650 745277010767 ribonuclease III; Reviewed; Region: rnc; PRK00102 745277010768 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 745277010769 dimerization interface [polypeptide binding]; other site 745277010770 active site 745277010771 metal binding site [ion binding]; metal-binding site 745277010772 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 745277010773 dsRNA binding site [nucleotide binding]; other site 745277010774 signal peptidase I; Provisional; Region: PRK10861 745277010775 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 745277010776 Catalytic site [active] 745277010777 GTP-binding protein LepA; Provisional; Region: PRK05433 745277010778 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 745277010779 G1 box; other site 745277010780 putative GEF interaction site [polypeptide binding]; other site 745277010781 GTP/Mg2+ binding site [chemical binding]; other site 745277010782 Switch I region; other site 745277010783 G2 box; other site 745277010784 G3 box; other site 745277010785 Switch II region; other site 745277010786 G4 box; other site 745277010787 G5 box; other site 745277010788 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 745277010789 Elongation Factor G, domain II; Region: EFG_II; pfam14492 745277010790 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 745277010791 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 745277010792 IncA protein; Region: IncA; pfam04156 745277010793 SoxR reducing system protein RseC; Provisional; Region: PRK10862 745277010794 anti-sigma E factor; Provisional; Region: rseB; PRK09455 745277010795 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 745277010796 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 745277010797 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 745277010798 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 745277010799 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 745277010800 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 745277010801 DNA binding residues [nucleotide binding] 745277010802 L-aspartate oxidase; Provisional; Region: PRK09077 745277010803 L-aspartate oxidase; Provisional; Region: PRK06175 745277010804 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 745277010805 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 745277010806 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277010807 S-adenosylmethionine binding site [chemical binding]; other site 745277010808 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 745277010809 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 745277010810 ATP binding site [chemical binding]; other site 745277010811 Mg++ binding site [ion binding]; other site 745277010812 motif III; other site 745277010813 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 745277010814 nucleotide binding region [chemical binding]; other site 745277010815 ATP-binding site [chemical binding]; other site 745277010816 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 745277010817 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 745277010818 ligand binding site [chemical binding]; other site 745277010819 active site 745277010820 UGI interface [polypeptide binding]; other site 745277010821 catalytic site [active] 745277010822 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 745277010823 dimer interface [polypeptide binding]; other site 745277010824 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 745277010825 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 745277010826 recombination and repair protein; Provisional; Region: PRK10869 745277010827 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 745277010828 Walker A/P-loop; other site 745277010829 ATP binding site [chemical binding]; other site 745277010830 Q-loop/lid; other site 745277010831 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 745277010832 Q-loop/lid; other site 745277010833 ABC transporter signature motif; other site 745277010834 Walker B; other site 745277010835 D-loop; other site 745277010836 H-loop/switch region; other site 745277010837 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 745277010838 hypothetical protein; Validated; Region: PRK01777 745277010839 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 745277010840 putative coenzyme Q binding site [chemical binding]; other site 745277010841 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 745277010842 SmpB-tmRNA interface; other site 745277010843 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 745277010844 Restriction endonuclease; Region: Mrr_cat; pfam04471 745277010845 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 745277010846 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 745277010847 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 745277010848 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 745277010849 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 745277010850 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 745277010851 active site 745277010852 phosphorylation site [posttranslational modification] 745277010853 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 745277010854 active site 745277010855 P-loop; other site 745277010856 phosphorylation site [posttranslational modification] 745277010857 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 745277010858 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 745277010859 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 745277010860 putative NAD(P) binding site [chemical binding]; other site 745277010861 catalytic Zn binding site [ion binding]; other site 745277010862 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 745277010863 intersubunit interface [polypeptide binding]; other site 745277010864 active site 745277010865 zinc binding site [ion binding]; other site 745277010866 Na+ binding site [ion binding]; other site 745277010867 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 745277010868 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 745277010869 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 745277010870 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745277010871 Coenzyme A binding pocket [chemical binding]; other site 745277010872 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 745277010873 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 745277010874 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277010875 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 745277010876 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 745277010877 DNA binding site [nucleotide binding] 745277010878 active site 745277010879 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 745277010880 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745277010881 Coenzyme A binding pocket [chemical binding]; other site 745277010882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 745277010883 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 745277010884 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745277010885 non-specific DNA binding site [nucleotide binding]; other site 745277010886 salt bridge; other site 745277010887 sequence-specific DNA binding site [nucleotide binding]; other site 745277010888 Cupin domain; Region: Cupin_2; cl17218 745277010889 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 745277010890 PA/protease or protease-like domain interface [polypeptide binding]; other site 745277010891 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 745277010892 metal binding site [ion binding]; metal-binding site 745277010893 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 745277010894 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745277010895 substrate binding pocket [chemical binding]; other site 745277010896 membrane-bound complex binding site; other site 745277010897 hinge residues; other site 745277010898 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 745277010899 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 745277010900 metal binding site [ion binding]; metal-binding site 745277010901 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277010902 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277010903 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 745277010904 dimerization interface [polypeptide binding]; other site 745277010905 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 745277010906 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 745277010907 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 745277010908 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 745277010909 hemolysin; Provisional; Region: PRK15087 745277010910 HD domain; Region: HD_3; pfam13023 745277010911 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 745277010912 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 745277010913 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 745277010914 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 745277010915 Walker A/P-loop; other site 745277010916 ATP binding site [chemical binding]; other site 745277010917 Q-loop/lid; other site 745277010918 ABC transporter signature motif; other site 745277010919 Walker B; other site 745277010920 D-loop; other site 745277010921 H-loop/switch region; other site 745277010922 TOBE domain; Region: TOBE_2; pfam08402 745277010923 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 745277010924 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 745277010925 active site 745277010926 metal binding site [ion binding]; metal-binding site 745277010927 hexamer interface [polypeptide binding]; other site 745277010928 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 745277010929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277010930 dimer interface [polypeptide binding]; other site 745277010931 conserved gate region; other site 745277010932 putative PBP binding loops; other site 745277010933 ABC-ATPase subunit interface; other site 745277010934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277010935 dimer interface [polypeptide binding]; other site 745277010936 conserved gate region; other site 745277010937 putative PBP binding loops; other site 745277010938 ABC-ATPase subunit interface; other site 745277010939 Putative toxin 60; Region: Toxin_60; pfam15607 745277010940 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 745277010941 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 745277010942 substrate binding site [chemical binding]; other site 745277010943 dimer interface [polypeptide binding]; other site 745277010944 ATP binding site [chemical binding]; other site 745277010945 D-allose kinase; Provisional; Region: PRK09698 745277010946 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 745277010947 nucleotide binding site [chemical binding]; other site 745277010948 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 745277010949 substrate binding site [chemical binding]; other site 745277010950 hexamer interface [polypeptide binding]; other site 745277010951 metal binding site [ion binding]; metal-binding site 745277010952 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 745277010953 TM-ABC transporter signature motif; other site 745277010954 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 745277010955 TM-ABC transporter signature motif; other site 745277010956 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 745277010957 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 745277010958 Walker A/P-loop; other site 745277010959 ATP binding site [chemical binding]; other site 745277010960 Q-loop/lid; other site 745277010961 ABC transporter signature motif; other site 745277010962 Walker B; other site 745277010963 D-loop; other site 745277010964 H-loop/switch region; other site 745277010965 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 745277010966 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 745277010967 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 745277010968 ligand binding site [chemical binding]; other site 745277010969 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 745277010970 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 745277010971 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 745277010972 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 745277010973 classical (c) SDRs; Region: SDR_c; cd05233 745277010974 NAD(P) binding site [chemical binding]; other site 745277010975 active site 745277010976 Transposase; Region: DEDD_Tnp_IS110; pfam01548 745277010977 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 745277010978 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 745277010979 glycine dehydrogenase; Provisional; Region: PRK05367 745277010980 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 745277010981 tetramer interface [polypeptide binding]; other site 745277010982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277010983 catalytic residue [active] 745277010984 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 745277010985 tetramer interface [polypeptide binding]; other site 745277010986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277010987 catalytic residue [active] 745277010988 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 745277010989 lipoyl attachment site [posttranslational modification]; other site 745277010990 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 745277010991 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 745277010992 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 745277010993 oxidoreductase; Provisional; Region: PRK08013 745277010994 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 745277010995 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 745277010996 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 745277010997 proline aminopeptidase P II; Provisional; Region: PRK10879 745277010998 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 745277010999 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 745277011000 active site 745277011001 hypothetical protein; Reviewed; Region: PRK01736 745277011002 Z-ring-associated protein; Provisional; Region: PRK10972 745277011003 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 745277011004 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 745277011005 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 745277011006 ligand binding site [chemical binding]; other site 745277011007 NAD binding site [chemical binding]; other site 745277011008 tetramer interface [polypeptide binding]; other site 745277011009 catalytic site [active] 745277011010 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 745277011011 L-serine binding site [chemical binding]; other site 745277011012 ACT domain interface; other site 745277011013 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 745277011014 tetramer (dimer of dimers) interface [polypeptide binding]; other site 745277011015 active site 745277011016 dimer interface [polypeptide binding]; other site 745277011017 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 745277011018 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277011019 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 745277011020 putative dimerization interface [polypeptide binding]; other site 745277011021 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277011022 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277011023 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 745277011024 putative effector binding pocket; other site 745277011025 putative dimerization interface [polypeptide binding]; other site 745277011026 short chain dehydrogenase; Provisional; Region: PRK08263 745277011027 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 745277011028 NADP binding site [chemical binding]; other site 745277011029 active site 745277011030 steroid binding site; other site 745277011031 Peptidase M66; Region: Peptidase_M66; pfam10462 745277011032 oxidative stress defense protein; Provisional; Region: PRK11087 745277011033 arginine exporter protein; Provisional; Region: PRK09304 745277011034 mechanosensitive channel MscS; Provisional; Region: PRK10334 745277011035 Conserved TM helix; Region: TM_helix; pfam05552 745277011036 Mechanosensitive ion channel; Region: MS_channel; pfam00924 745277011037 galactoside permease; Reviewed; Region: lacY; PRK09528 745277011038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277011039 putative substrate translocation pore; other site 745277011040 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 745277011041 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 745277011042 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 745277011043 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 745277011044 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 745277011045 lac repressor; Reviewed; Region: lacI; PRK09526 745277011046 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745277011047 DNA binding site [nucleotide binding] 745277011048 domain linker motif; other site 745277011049 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 745277011050 ligand binding site [chemical binding]; other site 745277011051 dimerization interface (open form) [polypeptide binding]; other site 745277011052 dimerization interface (closed form) [polypeptide binding]; other site 745277011053 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 745277011054 active site 745277011055 intersubunit interface [polypeptide binding]; other site 745277011056 zinc binding site [ion binding]; other site 745277011057 Na+ binding site [ion binding]; other site 745277011058 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 745277011059 substrate binding site [chemical binding]; other site 745277011060 hinge regions; other site 745277011061 ADP binding site [chemical binding]; other site 745277011062 catalytic site [active] 745277011063 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 745277011064 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 745277011065 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 745277011066 transketolase; Reviewed; Region: PRK12753 745277011067 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 745277011068 TPP-binding site [chemical binding]; other site 745277011069 dimer interface [polypeptide binding]; other site 745277011070 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 745277011071 PYR/PP interface [polypeptide binding]; other site 745277011072 dimer interface [polypeptide binding]; other site 745277011073 TPP binding site [chemical binding]; other site 745277011074 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 745277011075 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 745277011076 Fimbrial protein; Region: Fimbrial; cl01416 745277011077 putative chaperone protein EcpD; Provisional; Region: PRK09926 745277011078 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 745277011079 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 745277011080 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 745277011081 PapC N-terminal domain; Region: PapC_N; pfam13954 745277011082 Outer membrane usher protein; Region: Usher; pfam00577 745277011083 PapC C-terminal domain; Region: PapC_C; pfam13953 745277011084 Fimbrial protein; Region: Fimbrial; cl01416 745277011085 putative fimbrial protein StaE; Provisional; Region: PRK15263 745277011086 Fimbrial protein; Region: Fimbrial; cl01416 745277011087 Fimbrial protein; Region: Fimbrial; cl01416 745277011088 arginine decarboxylase; Provisional; Region: PRK05354 745277011089 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 745277011090 dimer interface [polypeptide binding]; other site 745277011091 active site 745277011092 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 745277011093 catalytic residues [active] 745277011094 substrate binding site [chemical binding]; other site 745277011095 S-adenosylmethionine synthetase; Validated; Region: PRK05250 745277011096 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 745277011097 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 745277011098 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 745277011099 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 745277011100 putative fimbrial protein TcfA; Provisional; Region: PRK15308 745277011101 CS1 type fimbrial major subunit; Region: Fimbrial_CS1; cl04524 745277011102 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 745277011103 Outer membrane usher protein; Region: Usher; pfam00577 745277011104 CblD like pilus biogenesis initiator; Region: CblD; cl06460 745277011105 CblD like pilus biogenesis initiator; Region: CblD; cl06460 745277011106 putative fimbrial protein TcfA; Provisional; Region: PRK15308 745277011107 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 745277011108 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 745277011109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277011110 putative substrate translocation pore; other site 745277011111 hypothetical protein; Provisional; Region: PRK04860 745277011112 DNA-specific endonuclease I; Provisional; Region: PRK15137 745277011113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 745277011114 glutathione synthetase; Provisional; Region: PRK05246 745277011115 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 745277011116 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 745277011117 hypothetical protein; Validated; Region: PRK00228 745277011118 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 745277011119 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 745277011120 Walker A motif; other site 745277011121 ATP binding site [chemical binding]; other site 745277011122 Walker B motif; other site 745277011123 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 745277011124 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 745277011125 catalytic residue [active] 745277011126 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 745277011127 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 745277011128 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 745277011129 YGGT family; Region: YGGT; pfam02325 745277011130 Predicted integral membrane protein [Function unknown]; Region: COG0762 745277011131 hypothetical protein; Validated; Region: PRK05090 745277011132 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 745277011133 active site 745277011134 dimerization interface [polypeptide binding]; other site 745277011135 HemN family oxidoreductase; Provisional; Region: PRK05660 745277011136 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 745277011137 FeS/SAM binding site; other site 745277011138 HemN C-terminal domain; Region: HemN_C; pfam06969 745277011139 hypothetical protein; Provisional; Region: PRK10626 745277011140 glutaminase; Provisional; Region: PRK00971 745277011141 hypothetical protein; Provisional; Region: PRK11702 745277011142 Methyltransferase domain; Region: Methyltransf_31; pfam13847 745277011143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277011144 S-adenosylmethionine binding site [chemical binding]; other site 745277011145 adenine DNA glycosylase; Provisional; Region: PRK10880 745277011146 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 745277011147 minor groove reading motif; other site 745277011148 helix-hairpin-helix signature motif; other site 745277011149 substrate binding pocket [chemical binding]; other site 745277011150 active site 745277011151 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 745277011152 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 745277011153 DNA binding and oxoG recognition site [nucleotide binding] 745277011154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2924 745277011155 murein transglycosylase C; Provisional; Region: mltC; PRK11671 745277011156 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 745277011157 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 745277011158 N-acetyl-D-glucosamine binding site [chemical binding]; other site 745277011159 catalytic residue [active] 745277011160 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 745277011161 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 745277011162 putative ADP-binding pocket [chemical binding]; other site 745277011163 Pectate lyase; Region: Pec_lyase_C; cl01593 745277011164 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 745277011165 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 745277011166 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 745277011167 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 745277011168 putative trimer interface [polypeptide binding]; other site 745277011169 putative CoA binding site [chemical binding]; other site 745277011170 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 745277011171 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 745277011172 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 745277011173 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 745277011174 tyrosine kinase; Provisional; Region: PRK11519 745277011175 Chain length determinant protein; Region: Wzz; pfam02706 745277011176 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 745277011177 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 745277011178 Low molecular weight phosphatase family; Region: LMWPc; cd00115 745277011179 active site 745277011180 polysaccharide export protein Wza; Provisional; Region: PRK15078 745277011181 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 745277011182 SLBB domain; Region: SLBB; pfam10531 745277011183 SLBB domain; Region: SLBB; pfam10531 745277011184 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 745277011185 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 745277011186 Mg++ binding site [ion binding]; other site 745277011187 putative catalytic motif [active] 745277011188 substrate binding site [chemical binding]; other site 745277011189 ornithine decarboxylase; Provisional; Region: PRK13578 745277011190 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 745277011191 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 745277011192 homodimer interface [polypeptide binding]; other site 745277011193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277011194 catalytic residue [active] 745277011195 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 745277011196 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; cl19622 745277011197 S-type Pyocin; Region: Pyocin_S; pfam06958 745277011198 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 745277011199 active site 745277011200 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 745277011201 Transposase; Region: HTH_Tnp_1; pfam01527 745277011202 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 745277011203 trimer interface [polypeptide binding]; other site 745277011204 active site 745277011205 substrate binding site [chemical binding]; other site 745277011206 CoA binding site [chemical binding]; other site 745277011207 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 745277011208 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 745277011209 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 745277011210 putative catalytic site [active] 745277011211 putative metal binding site [ion binding]; other site 745277011212 putative phosphate binding site [ion binding]; other site 745277011213 cardiolipin synthase 2; Provisional; Region: PRK11263 745277011214 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 745277011215 putative active site [active] 745277011216 catalytic site [active] 745277011217 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 745277011218 putative active site [active] 745277011219 catalytic site [active] 745277011220 Predicted integral membrane protein [Function unknown]; Region: COG0392 745277011221 manganese transport protein MntH; Reviewed; Region: PRK00701 745277011222 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 745277011223 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 745277011224 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 745277011225 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 745277011226 dimer interface [polypeptide binding]; other site 745277011227 putative CheW interface [polypeptide binding]; other site 745277011228 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 745277011229 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 745277011230 ligand binding site [chemical binding]; other site 745277011231 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 745277011232 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 745277011233 NADP-binding site; other site 745277011234 homotetramer interface [polypeptide binding]; other site 745277011235 homodimer interface [polypeptide binding]; other site 745277011236 active site 745277011237 substrate binding site [chemical binding]; other site 745277011238 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 745277011239 putative ADP-binding pocket [chemical binding]; other site 745277011240 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 745277011241 phosphomannomutase CpsG; Provisional; Region: PRK15414 745277011242 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 745277011243 active site 745277011244 substrate binding site [chemical binding]; other site 745277011245 metal binding site [ion binding]; metal-binding site 745277011246 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 745277011247 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 745277011248 Substrate binding site; other site 745277011249 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 745277011250 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 745277011251 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 745277011252 active site 745277011253 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 745277011254 colanic acid exporter; Provisional; Region: PRK10459 745277011255 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 745277011256 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 745277011257 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 745277011258 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 745277011259 putative ADP-binding pocket [chemical binding]; other site 745277011260 Right handed beta helix region; Region: Beta_helix; pfam13229 745277011261 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 745277011262 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 745277011263 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 745277011264 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 745277011265 tyrosine kinase; Provisional; Region: PRK11519 745277011266 Chain length determinant protein; Region: Wzz; pfam02706 745277011267 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 745277011268 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 745277011269 Low molecular weight phosphatase family; Region: LMWPc; cd00115 745277011270 active site 745277011271 polysaccharide export protein Wza; Provisional; Region: PRK15078 745277011272 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 745277011273 SLBB domain; Region: SLBB; pfam10531 745277011274 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 745277011275 CoA binding domain; Region: CoA_binding; cl17356 745277011276 Bacterial sugar transferase; Region: Bac_transf; pfam02397 745277011277 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 745277011278 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 745277011279 Group 4 capsule polysaccharide formation lipoprotein gfcB; Region: Cap_synth_GfcB; pfam11102 745277011280 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 745277011281 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 745277011282 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 745277011283 DNA binding residues [nucleotide binding] 745277011284 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 745277011285 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 745277011286 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745277011287 non-specific DNA binding site [nucleotide binding]; other site 745277011288 salt bridge; other site 745277011289 sequence-specific DNA binding site [nucleotide binding]; other site 745277011290 Cupin domain; Region: Cupin_2; pfam07883 745277011291 AzlC protein; Region: AzlC; cl00570 745277011292 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 745277011293 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 745277011294 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 745277011295 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 745277011296 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 745277011297 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277011298 LysE type translocator; Region: LysE; cl00565 745277011299 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745277011300 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 745277011301 substrate binding pocket [chemical binding]; other site 745277011302 membrane-bound complex binding site; other site 745277011303 hinge residues; other site 745277011304 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 745277011305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277011306 dimer interface [polypeptide binding]; other site 745277011307 conserved gate region; other site 745277011308 putative PBP binding loops; other site 745277011309 ABC-ATPase subunit interface; other site 745277011310 capreomycidine synthase; Region: viomycin_VioD; TIGR03947 745277011311 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 745277011312 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277011313 homodimer interface [polypeptide binding]; other site 745277011314 catalytic residue [active] 745277011315 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 745277011316 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 745277011317 putative sugar binding site [chemical binding]; other site 745277011318 catalytic residues [active] 745277011319 Cadherin repeat-like domain; Region: CA_like; cl15786 745277011320 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 745277011321 aromatic chitin/cellulose binding site residues [chemical binding]; other site 745277011322 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277011323 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277011324 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 745277011325 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 745277011326 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 745277011327 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 745277011328 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 745277011329 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 745277011330 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 745277011331 active site 745277011332 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 745277011333 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 745277011334 aromatic chitin/cellulose binding site residues [chemical binding]; other site 745277011335 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277011336 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277011337 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 745277011338 putative effector binding pocket; other site 745277011339 putative dimerization interface [polypeptide binding]; other site 745277011340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277011341 Major Facilitator Superfamily; Region: MFS_1; pfam07690 745277011342 putative substrate translocation pore; other site 745277011343 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 745277011344 DNA-binding site [nucleotide binding]; DNA binding site 745277011345 RNA-binding motif; other site 745277011346 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 745277011347 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 745277011348 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 745277011349 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 745277011350 shikimate binding site; other site 745277011351 NAD(P) binding site [chemical binding]; other site 745277011352 ornithine decarboxylase; Provisional; Region: PRK13578 745277011353 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 745277011354 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 745277011355 homodimer interface [polypeptide binding]; other site 745277011356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277011357 catalytic residue [active] 745277011358 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 745277011359 putrescine transporter; Provisional; Region: potE; PRK10655 745277011360 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 745277011361 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 745277011362 active site 745277011363 tetramer interface [polypeptide binding]; other site 745277011364 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 745277011365 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 745277011366 active site 745277011367 tetramer interface [polypeptide binding]; other site 745277011368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277011369 D-galactonate transporter; Region: 2A0114; TIGR00893 745277011370 putative substrate translocation pore; other site 745277011371 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 745277011372 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 745277011373 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 745277011374 Transposase IS200 like; Region: Y1_Tnp; pfam01797 745277011375 serine endoprotease; Provisional; Region: PRK10942 745277011376 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 745277011377 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 745277011378 protein binding site [polypeptide binding]; other site 745277011379 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 745277011380 protein binding site [polypeptide binding]; other site 745277011381 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 745277011382 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 745277011383 Zn2+ binding site [ion binding]; other site 745277011384 Mg2+ binding site [ion binding]; other site 745277011385 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 745277011386 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 745277011387 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 745277011388 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 745277011389 cobalamin binding residues [chemical binding]; other site 745277011390 putative BtuC binding residues; other site 745277011391 dimer interface [polypeptide binding]; other site 745277011392 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 745277011393 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 745277011394 Cl- selectivity filter; other site 745277011395 Cl- binding residues [ion binding]; other site 745277011396 pore gating glutamate residue; other site 745277011397 dimer interface [polypeptide binding]; other site 745277011398 H+/Cl- coupling transport residue; other site 745277011399 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 745277011400 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 745277011401 inhibitor-cofactor binding pocket; inhibition site 745277011402 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277011403 catalytic residue [active] 745277011404 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 745277011405 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 745277011406 Autotransporter beta-domain; Region: Autotransporter; smart00869 745277011407 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 745277011408 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 745277011409 ABC-ATPase subunit interface; other site 745277011410 dimer interface [polypeptide binding]; other site 745277011411 putative PBP binding regions; other site 745277011412 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 745277011413 ABC-ATPase subunit interface; other site 745277011414 dimer interface [polypeptide binding]; other site 745277011415 putative PBP binding regions; other site 745277011416 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 745277011417 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 745277011418 siderophore binding site; other site 745277011419 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 745277011420 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 745277011421 Walker A/P-loop; other site 745277011422 ATP binding site [chemical binding]; other site 745277011423 Q-loop/lid; other site 745277011424 ABC transporter signature motif; other site 745277011425 Walker B; other site 745277011426 D-loop; other site 745277011427 H-loop/switch region; other site 745277011428 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 745277011429 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 745277011430 N-terminal plug; other site 745277011431 ligand-binding site [chemical binding]; other site 745277011432 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 745277011433 active site 745277011434 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 745277011435 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 745277011436 Nucleoside recognition; Region: Gate; pfam07670 745277011437 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 745277011438 Helix-turn-helix domain; Region: HTH_17; pfam12728 745277011439 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 745277011440 Transmembrane domain of transglycosylase PBP1 at N-terminal; Region: PBP1_TM; pfam14812 745277011441 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 745277011442 Transglycosylase; Region: Transgly; pfam00912 745277011443 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 745277011444 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 745277011445 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 745277011446 ATP binding site [chemical binding]; other site 745277011447 putative Mg++ binding site [ion binding]; other site 745277011448 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 745277011449 nucleotide binding region [chemical binding]; other site 745277011450 ATP-binding site [chemical binding]; other site 745277011451 Helicase associated domain (HA2); Region: HA2; pfam04408 745277011452 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 745277011453 2'-5' RNA ligase; Provisional; Region: PRK15124 745277011454 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 745277011455 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 745277011456 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 745277011457 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 745277011458 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 745277011459 active site 745277011460 nucleotide binding site [chemical binding]; other site 745277011461 HIGH motif; other site 745277011462 KMSKS motif; other site 745277011463 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 745277011464 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 745277011465 active site 745277011466 NTP binding site [chemical binding]; other site 745277011467 metal binding triad [ion binding]; metal-binding site 745277011468 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 745277011469 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 745277011470 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 745277011471 catalytic center binding site [active] 745277011472 ATP binding site [chemical binding]; other site 745277011473 sensor protein QseC; Provisional; Region: PRK10337 745277011474 HAMP domain; Region: HAMP; pfam00672 745277011475 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745277011476 dimer interface [polypeptide binding]; other site 745277011477 phosphorylation site [posttranslational modification] 745277011478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277011479 ATP binding site [chemical binding]; other site 745277011480 Mg2+ binding site [ion binding]; other site 745277011481 G-X-G motif; other site 745277011482 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 745277011483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277011484 active site 745277011485 phosphorylation site [posttranslational modification] 745277011486 intermolecular recognition site; other site 745277011487 dimerization interface [polypeptide binding]; other site 745277011488 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 745277011489 DNA binding site [nucleotide binding] 745277011490 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 745277011491 oligomerization interface [polypeptide binding]; other site 745277011492 active site 745277011493 metal binding site [ion binding]; metal-binding site 745277011494 Pantoate-beta-alanine ligase; Region: PanC; cd00560 745277011495 active site 745277011496 ATP-binding site [chemical binding]; other site 745277011497 pantoate-binding site; other site 745277011498 HXXH motif; other site 745277011499 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 745277011500 tetramerization interface [polypeptide binding]; other site 745277011501 active site 745277011502 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 745277011503 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 745277011504 putative transposase OrfB; Reviewed; Region: PHA02517 745277011505 HTH-like domain; Region: HTH_21; pfam13276 745277011506 Integrase core domain; Region: rve; pfam00665 745277011507 Integrase core domain; Region: rve_2; pfam13333 745277011508 inner membrane transport permease; Provisional; Region: PRK15066 745277011509 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 745277011510 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 745277011511 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 745277011512 Walker A/P-loop; other site 745277011513 ATP binding site [chemical binding]; other site 745277011514 Q-loop/lid; other site 745277011515 ABC transporter signature motif; other site 745277011516 Walker B; other site 745277011517 D-loop; other site 745277011518 H-loop/switch region; other site 745277011519 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 745277011520 active site clefts [active] 745277011521 zinc binding site [ion binding]; other site 745277011522 dimer interface [polypeptide binding]; other site 745277011523 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 745277011524 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 745277011525 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 745277011526 active site 745277011527 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 745277011528 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 745277011529 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 745277011530 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 745277011531 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 745277011532 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 745277011533 putative NAD(P) binding site [chemical binding]; other site 745277011534 active site 745277011535 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 745277011536 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 745277011537 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 745277011538 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 745277011539 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 745277011540 multicopper oxidase; Provisional; Region: PRK10965 745277011541 The first Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_1_CueO_FtsP; cd04232 745277011542 Domain 2 interface [polypeptide binding]; other site 745277011543 Domain 3 interface [polypeptide binding]; other site 745277011544 trinuclear Cu binding site [ion binding]; other site 745277011545 The second Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_2_CueO_FtsP; cd13867 745277011546 Domain 1 interface [polypeptide binding]; other site 745277011547 Domain 3 interface [polypeptide binding]; other site 745277011548 The third Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_3_CueO_FtsP; cd13890 745277011549 Domain 2 interface [polypeptide binding]; other site 745277011550 Domain 1 interface [polypeptide binding]; other site 745277011551 Type 1 (T1) Cu binding site [ion binding]; other site 745277011552 trinuclear Cu binding site [ion binding]; other site 745277011553 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 745277011554 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 745277011555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277011556 S-adenosylmethionine binding site [chemical binding]; other site 745277011557 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 745277011558 aromatic amino acid exporter; Provisional; Region: PRK11689 745277011559 EamA-like transporter family; Region: EamA; pfam00892 745277011560 hypothetical protein; Provisional; Region: PRK05248 745277011561 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 745277011562 Aconitate B N-terminal domain; Region: Aconitase_B_N; pfam11791 745277011563 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 745277011564 substrate binding site [chemical binding]; other site 745277011565 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 745277011566 substrate binding site [chemical binding]; other site 745277011567 ligand binding site [chemical binding]; other site 745277011568 putative major fimbrial protein SthE; Provisional; Region: PRK15292 745277011569 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 745277011570 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 745277011571 PapC N-terminal domain; Region: PapC_N; pfam13954 745277011572 Outer membrane usher protein; Region: Usher; pfam00577 745277011573 PapC C-terminal domain; Region: PapC_C; pfam13953 745277011574 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 745277011575 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 745277011576 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 745277011577 Fimbrial protein; Region: Fimbrial; cl01416 745277011578 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 745277011579 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 745277011580 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277011581 dimer interface [polypeptide binding]; other site 745277011582 conserved gate region; other site 745277011583 putative PBP binding loops; other site 745277011584 ABC-ATPase subunit interface; other site 745277011585 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 745277011586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277011587 dimer interface [polypeptide binding]; other site 745277011588 conserved gate region; other site 745277011589 putative PBP binding loops; other site 745277011590 ABC-ATPase subunit interface; other site 745277011591 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 745277011592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745277011593 Walker A/P-loop; other site 745277011594 ATP binding site [chemical binding]; other site 745277011595 Q-loop/lid; other site 745277011596 ABC transporter signature motif; other site 745277011597 Walker B; other site 745277011598 D-loop; other site 745277011599 H-loop/switch region; other site 745277011600 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 745277011601 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 745277011602 active site 745277011603 catalytic site [active] 745277011604 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 745277011605 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 745277011606 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 745277011607 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 745277011608 active site 745277011609 catalytic site [active] 745277011610 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 745277011611 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 745277011612 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 745277011613 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 745277011614 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 745277011615 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 745277011616 E3 interaction surface; other site 745277011617 lipoyl attachment site [posttranslational modification]; other site 745277011618 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 745277011619 E3 interaction surface; other site 745277011620 lipoyl attachment site [posttranslational modification]; other site 745277011621 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 745277011622 E3 interaction surface; other site 745277011623 lipoyl attachment site [posttranslational modification]; other site 745277011624 e3 binding domain; Region: E3_binding; pfam02817 745277011625 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 745277011626 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 745277011627 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 745277011628 dimer interface [polypeptide binding]; other site 745277011629 TPP-binding site [chemical binding]; other site 745277011630 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 745277011631 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 745277011632 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745277011633 DNA-binding site [nucleotide binding]; DNA binding site 745277011634 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 745277011635 aromatic amino acid transporter; Provisional; Region: PRK10238 745277011636 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 745277011637 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 745277011638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277011639 putative substrate translocation pore; other site 745277011640 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 745277011641 active site 745277011642 regulatory protein AmpE; Provisional; Region: PRK10987 745277011643 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 745277011644 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 745277011645 amidase catalytic site [active] 745277011646 Zn binding residues [ion binding]; other site 745277011647 substrate binding site [chemical binding]; other site 745277011648 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 745277011649 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 745277011650 dimerization interface [polypeptide binding]; other site 745277011651 active site 745277011652 putative major pilin subunit; Provisional; Region: PRK10574 745277011653 hypothetical protein; Provisional; Region: PRK10436 745277011654 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 745277011655 Walker A motif; other site 745277011656 ATP binding site [chemical binding]; other site 745277011657 Walker B motif; other site 745277011658 type IV pilin biogenesis protein; Provisional; Region: PRK10573 745277011659 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 745277011660 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 745277011661 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 745277011662 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 745277011663 active site 745277011664 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 745277011665 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 745277011666 CoA-binding site [chemical binding]; other site 745277011667 ATP-binding [chemical binding]; other site 745277011668 hypothetical protein; Provisional; Region: PRK05287 745277011669 DNA gyrase inhibitor; Reviewed; Region: PRK00418 745277011670 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 745277011671 active site 745277011672 8-oxo-dGMP binding site [chemical binding]; other site 745277011673 nudix motif; other site 745277011674 metal binding site [ion binding]; metal-binding site 745277011675 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 745277011676 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 745277011677 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 745277011678 SEC-C motif; Region: SEC-C; pfam02810 745277011679 SecA regulator SecM; Provisional; Region: PRK02943 745277011680 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4701 745277011681 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 745277011682 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 745277011683 cell division protein FtsZ; Validated; Region: PRK09330 745277011684 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 745277011685 nucleotide binding site [chemical binding]; other site 745277011686 SulA interaction site; other site 745277011687 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 745277011688 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 745277011689 Cell division protein FtsA; Region: FtsA; pfam14450 745277011690 cell division protein FtsQ; Provisional; Region: PRK10775 745277011691 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 745277011692 Cell division protein FtsQ; Region: FtsQ; pfam03799 745277011693 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 745277011694 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 745277011695 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 745277011696 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 745277011697 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 745277011698 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 745277011699 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 745277011700 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 745277011701 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 745277011702 active site 745277011703 homodimer interface [polypeptide binding]; other site 745277011704 cell division protein FtsW; Provisional; Region: PRK10774 745277011705 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 745277011706 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 745277011707 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 745277011708 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 745277011709 Mg++ binding site [ion binding]; other site 745277011710 putative catalytic motif [active] 745277011711 putative substrate binding site [chemical binding]; other site 745277011712 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 745277011713 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 745277011714 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 745277011715 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 745277011716 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 745277011717 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 745277011718 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 745277011719 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 745277011720 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 745277011721 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 745277011722 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 745277011723 cell division protein FtsL; Provisional; Region: PRK10772 745277011724 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 745277011725 cell division protein MraZ; Reviewed; Region: PRK00326 745277011726 MraZ protein; Region: MraZ; pfam02381 745277011727 MraZ protein; Region: MraZ; pfam02381 745277011728 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 745277011729 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745277011730 DNA binding site [nucleotide binding] 745277011731 domain linker motif; other site 745277011732 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 745277011733 dimerization interface [polypeptide binding]; other site 745277011734 ligand binding site [chemical binding]; other site 745277011735 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 745277011736 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 745277011737 putative valine binding site [chemical binding]; other site 745277011738 dimer interface [polypeptide binding]; other site 745277011739 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 745277011740 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 745277011741 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 745277011742 PYR/PP interface [polypeptide binding]; other site 745277011743 dimer interface [polypeptide binding]; other site 745277011744 TPP binding site [chemical binding]; other site 745277011745 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 745277011746 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 745277011747 TPP-binding site [chemical binding]; other site 745277011748 dimer interface [polypeptide binding]; other site 745277011749 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 745277011750 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 745277011751 acyl-activating enzyme (AAE) consensus motif; other site 745277011752 putative AMP binding site [chemical binding]; other site 745277011753 putative active site [active] 745277011754 putative CoA binding site [chemical binding]; other site 745277011755 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 745277011756 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277011757 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 745277011758 putative substrate binding pocket [chemical binding]; other site 745277011759 putative dimerization interface [polypeptide binding]; other site 745277011760 2-isopropylmalate synthase; Validated; Region: PRK00915 745277011761 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 745277011762 active site 745277011763 catalytic residues [active] 745277011764 metal binding site [ion binding]; metal-binding site 745277011765 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 745277011766 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 745277011767 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 745277011768 substrate binding site [chemical binding]; other site 745277011769 ligand binding site [chemical binding]; other site 745277011770 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 745277011771 substrate binding site [chemical binding]; other site 745277011772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277011773 sugar efflux transporter; Region: 2A0120; TIGR00899 745277011774 putative substrate translocation pore; other site 745277011775 transcriptional regulator SgrR; Provisional; Region: PRK13626 745277011776 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 745277011777 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 745277011778 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 745277011779 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 745277011780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277011781 dimer interface [polypeptide binding]; other site 745277011782 conserved gate region; other site 745277011783 putative PBP binding loops; other site 745277011784 ABC-ATPase subunit interface; other site 745277011785 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277011786 dimer interface [polypeptide binding]; other site 745277011787 conserved gate region; other site 745277011788 putative PBP binding loops; other site 745277011789 ABC-ATPase subunit interface; other site 745277011790 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 745277011791 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745277011792 Walker A/P-loop; other site 745277011793 ATP binding site [chemical binding]; other site 745277011794 Q-loop/lid; other site 745277011795 ABC transporter signature motif; other site 745277011796 Walker B; other site 745277011797 D-loop; other site 745277011798 H-loop/switch region; other site 745277011799 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 745277011800 DNA polymerase II; Reviewed; Region: PRK05762 745277011801 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 745277011802 active site 745277011803 catalytic site [active] 745277011804 substrate binding site [chemical binding]; other site 745277011805 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 745277011806 active site 745277011807 metal-binding site 745277011808 ATP-dependent helicase HepA; Validated; Region: PRK04914 745277011809 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 745277011810 ATP binding site [chemical binding]; other site 745277011811 putative Mg++ binding site [ion binding]; other site 745277011812 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 745277011813 nucleotide binding region [chemical binding]; other site 745277011814 ATP-binding site [chemical binding]; other site 745277011815 RNA polymerase recycling family C-terminal; Region: RapA_C; pfam12137 745277011816 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 745277011817 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 745277011818 active site 745277011819 Transposase IS200 like; Region: Y1_Tnp; pfam01797 745277011820 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 745277011821 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 745277011822 putative metal binding site [ion binding]; other site 745277011823 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 745277011824 HSP70 interaction site [polypeptide binding]; other site 745277011825 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 745277011826 OstA-like protein; Region: OstA; pfam03968 745277011827 Organic solvent tolerance protein; Region: OstA_C; pfam04453 745277011828 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 745277011829 SurA N-terminal domain; Region: SurA_N; pfam09312 745277011830 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 745277011831 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 745277011832 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 745277011833 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277011834 S-adenosylmethionine binding site [chemical binding]; other site 745277011835 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 745277011836 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 745277011837 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 745277011838 active site 745277011839 metal binding site [ion binding]; metal-binding site 745277011840 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 745277011841 folate binding site [chemical binding]; other site 745277011842 NADP+ binding site [chemical binding]; other site 745277011843 hypothetical protein; Provisional; Region: PRK09917 745277011844 Uncharacterized conserved protein [Function unknown]; Region: COG2966 745277011845 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 745277011846 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 745277011847 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 745277011848 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 745277011849 TrkA-N domain; Region: TrkA_N; pfam02254 745277011850 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 745277011851 N-terminal Early set domain associated with the catalytic domain of chitinase; Region: E_set_Chitinase_N; cd02848 745277011852 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 745277011853 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 745277011854 active site 745277011855 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 745277011856 aromatic chitin/cellulose binding site residues [chemical binding]; other site 745277011857 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 745277011858 aromatic chitin/cellulose binding site residues [chemical binding]; other site 745277011859 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 745277011860 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 745277011861 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 745277011862 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 745277011863 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 745277011864 ATP-grasp domain; Region: ATP-grasp_4; cl17255 745277011865 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 745277011866 IMP binding site; other site 745277011867 dimer interface [polypeptide binding]; other site 745277011868 interdomain contacts; other site 745277011869 partial ornithine binding site; other site 745277011870 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 745277011871 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 745277011872 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 745277011873 catalytic site [active] 745277011874 subunit interface [polypeptide binding]; other site 745277011875 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 745277011876 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 745277011877 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 745277011878 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 745277011879 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 745277011880 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 745277011881 Fe-S cluster binding site [ion binding]; other site 745277011882 substrate binding site [chemical binding]; other site 745277011883 catalytic site [active] 745277011884 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 745277011885 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 745277011886 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 745277011887 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 745277011888 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 745277011889 active site 745277011890 HIGH motif; other site 745277011891 KMSKS motif; other site 745277011892 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 745277011893 tRNA binding surface [nucleotide binding]; other site 745277011894 anticodon binding site; other site 745277011895 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 745277011896 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 745277011897 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 745277011898 active site 745277011899 Riboflavin kinase; Region: Flavokinase; smart00904 745277011900 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 745277011901 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 745277011902 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277011903 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 745277011904 dimerization interface [polypeptide binding]; other site 745277011905 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 745277011906 chaperone protein DnaJ; Provisional; Region: PRK10767 745277011907 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 745277011908 HSP70 interaction site [polypeptide binding]; other site 745277011909 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 745277011910 substrate binding site [polypeptide binding]; other site 745277011911 dimer interface [polypeptide binding]; other site 745277011912 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 745277011913 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 745277011914 nucleotide binding site [chemical binding]; other site 745277011915 hypothetical protein; Provisional; Region: PRK10659 745277011916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277011917 metabolite-proton symporter; Region: 2A0106; TIGR00883 745277011918 putative substrate translocation pore; other site 745277011919 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 745277011920 MPT binding site; other site 745277011921 trimer interface [polypeptide binding]; other site 745277011922 transaldolase-like protein; Provisional; Region: PTZ00411 745277011923 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 745277011924 active site 745277011925 dimer interface [polypeptide binding]; other site 745277011926 catalytic residue [active] 745277011927 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 745277011928 hypothetical protein; Validated; Region: PRK02101 745277011929 threonine synthase; Validated; Region: PRK09225 745277011930 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 745277011931 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 745277011932 catalytic residue [active] 745277011933 homoserine kinase; Provisional; Region: PRK01212 745277011934 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 745277011935 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 745277011936 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 745277011937 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 745277011938 putative catalytic residues [active] 745277011939 putative nucleotide binding site [chemical binding]; other site 745277011940 putative aspartate binding site [chemical binding]; other site 745277011941 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 745277011942 dimer interface [polypeptide binding]; other site 745277011943 putative threonine allosteric regulatory site; other site 745277011944 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 745277011945 putative threonine allosteric regulatory site; other site 745277011946 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 745277011947 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 745277011948 threonine operon leader; IMG reference gene:2506710921 745277011949 putative RNA methyltransferase; Provisional; Region: PRK10433 745277011950 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 745277011951 two-component response regulator; Provisional; Region: PRK11173 745277011952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277011953 active site 745277011954 phosphorylation site [posttranslational modification] 745277011955 intermolecular recognition site; other site 745277011956 dimerization interface [polypeptide binding]; other site 745277011957 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 745277011958 DNA binding site [nucleotide binding] 745277011959 hypothetical protein; Provisional; Region: PRK10756 745277011960 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 745277011961 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277011962 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277011963 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 745277011964 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 745277011965 catalytic core [active] 745277011966 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 745277011967 Trp operon repressor; Provisional; Region: PRK01381 745277011968 lytic murein transglycosylase; Provisional; Region: PRK11619 745277011969 Soluble lytic murein transglycosylase L domain; Region: SLT_L; pfam14718 745277011970 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 745277011971 N-acetyl-D-glucosamine binding site [chemical binding]; other site 745277011972 catalytic residue [active] 745277011973 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 745277011974 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 745277011975 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 745277011976 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 745277011977 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745277011978 active site 745277011979 motif I; other site 745277011980 motif II; other site 745277011981 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 745277011982 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 745277011983 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 745277011984 DNA binding residues [nucleotide binding] 745277011985 dimerization interface [polypeptide binding]; other site 745277011986 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 745277011987 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 745277011988 ABC transporter; Region: ABC_tran_2; pfam12848 745277011989 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 745277011990 LysR family transcriptional regulator; Provisional; Region: PRK14997 745277011991 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277011992 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 745277011993 putative effector binding pocket; other site 745277011994 dimerization interface [polypeptide binding]; other site 745277011995 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 745277011996 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 745277011997 putative NAD(P) binding site [chemical binding]; other site 745277011998 dimer interface [polypeptide binding]; other site 745277011999 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 745277012000 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 745277012001 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745277012002 non-specific DNA binding site [nucleotide binding]; other site 745277012003 salt bridge; other site 745277012004 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 745277012005 sequence-specific DNA binding site [nucleotide binding]; other site 745277012006 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 745277012007 active site 745277012008 (T/H)XGH motif; other site 745277012009 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 745277012010 DNA repair protein RadA; Region: sms; TIGR00416 745277012011 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 745277012012 Walker A motif/ATP binding site; other site 745277012013 ATP binding site [chemical binding]; other site 745277012014 Walker B motif; other site 745277012015 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 745277012016 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 745277012017 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745277012018 motif II; other site 745277012019 hypothetical protein; Provisional; Region: PRK11246 745277012020 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 745277012021 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 745277012022 putative Zn2+ binding site [ion binding]; other site 745277012023 HipA-like N-terminal domain; Region: HipA_N; pfam07805 745277012024 HipA-like C-terminal domain; Region: HipA_C; pfam07804 745277012025 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 745277012026 phosphopentomutase; Provisional; Region: PRK05362 745277012027 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 745277012028 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 745277012029 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 745277012030 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 745277012031 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 745277012032 intersubunit interface [polypeptide binding]; other site 745277012033 active site 745277012034 catalytic residue [active] 745277012035 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 745277012036 active site 745277012037 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 745277012038 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 745277012039 active site 745277012040 nucleophile elbow; other site 745277012041 periplasmic protein; Provisional; Region: PRK10568 745277012042 BON domain; Region: BON; pfam04972 745277012043 BON domain; Region: BON; pfam04972 745277012044 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 745277012045 aromatic chitin/cellulose binding site residues [chemical binding]; other site 745277012046 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 745277012047 active site 745277012048 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 745277012049 Rib/alpha-like repeat; Region: Rib; cl07159 745277012050 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 745277012051 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 745277012052 G1 box; other site 745277012053 putative GEF interaction site [polypeptide binding]; other site 745277012054 GTP/Mg2+ binding site [chemical binding]; other site 745277012055 Switch I region; other site 745277012056 G2 box; other site 745277012057 G3 box; other site 745277012058 Switch II region; other site 745277012059 G4 box; other site 745277012060 G5 box; other site 745277012061 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 745277012062 HipA N-terminal domain; Region: Couple_hipA; pfam13657 745277012063 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 745277012064 HipA-like N-terminal domain; Region: HipA_N; pfam07805 745277012065 HipA-like C-terminal domain; Region: HipA_C; pfam07804 745277012066 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745277012067 non-specific DNA binding site [nucleotide binding]; other site 745277012068 salt bridge; other site 745277012069 sequence-specific DNA binding site [nucleotide binding]; other site 745277012070 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 745277012071 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745277012072 Coenzyme A binding pocket [chemical binding]; other site 745277012073 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 745277012074 DNA polymerase III subunit psi; Validated; Region: PRK06856 745277012075 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 745277012076 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 745277012077 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277012078 S-adenosylmethionine binding site [chemical binding]; other site 745277012079 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 745277012080 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 745277012081 active site 745277012082 catalytic tetrad [active] 745277012083 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277012084 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277012085 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 745277012086 putative effector binding pocket; other site 745277012087 putative dimerization interface [polypeptide binding]; other site 745277012088 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 745277012089 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745277012090 metal binding site [ion binding]; metal-binding site 745277012091 active site 745277012092 I-site; other site 745277012093 Sugar transport protein; Region: Sugar_transport; cl19288 745277012094 transcriptional activator RhaR; Provisional; Region: PRK13501 745277012095 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 745277012096 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277012097 transcriptional activator RhaS; Provisional; Region: PRK13503 745277012098 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 745277012099 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277012100 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277012101 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 745277012102 N- and C-terminal domain interface [polypeptide binding]; other site 745277012103 active site 745277012104 putative catalytic site [active] 745277012105 metal binding site [ion binding]; metal-binding site 745277012106 ATP binding site [chemical binding]; other site 745277012107 rhamnulokinase; Provisional; Region: rhaB; PRK10640 745277012108 carbohydrate binding site [chemical binding]; other site 745277012109 L-rhamnose isomerase; Provisional; Region: PRK01076 745277012110 rhamnulose-1-phosphate aldolase; Provisional; Region: PRK03634 745277012111 intersubunit interface [polypeptide binding]; other site 745277012112 active site 745277012113 Zn2+ binding site [ion binding]; other site 745277012114 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 745277012115 dimer interface [polypeptide binding]; other site 745277012116 active site 745277012117 metal binding site [ion binding]; metal-binding site 745277012118 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 745277012119 hypothetical protein; Provisional; Region: PRK01254 745277012120 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 745277012121 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 745277012122 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 745277012123 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 745277012124 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 745277012125 Sulfate transporter family; Region: Sulfate_transp; cl19250 745277012126 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 745277012127 Dak1 domain; Region: Dak1; cl10557 745277012128 DAK2 domain; Region: Dak2; pfam02734 745277012129 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 745277012130 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 745277012131 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 745277012132 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 745277012133 serine transporter; Region: stp; TIGR00814 745277012134 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 745277012135 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 745277012136 HAMP domain; Region: HAMP; pfam00672 745277012137 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745277012138 metal binding site [ion binding]; metal-binding site 745277012139 active site 745277012140 I-site; other site 745277012141 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 745277012142 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 745277012143 ligand binding site [chemical binding]; other site 745277012144 AAA domain; Region: AAA_11; pfam13086 745277012145 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 745277012146 G1 box; other site 745277012147 GTP/Mg2+ binding site [chemical binding]; other site 745277012148 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 745277012149 AAA domain; Region: AAA_12; pfam13087 745277012150 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 745277012151 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 745277012152 putative active site [active] 745277012153 catalytic site [active] 745277012154 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277012155 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277012156 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 745277012157 putative dimerization interface [polypeptide binding]; other site 745277012158 putative substrate binding pocket [chemical binding]; other site 745277012159 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 745277012160 acetolactate synthase; Reviewed; Region: PRK08617 745277012161 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 745277012162 PYR/PP interface [polypeptide binding]; other site 745277012163 dimer interface [polypeptide binding]; other site 745277012164 TPP binding site [chemical binding]; other site 745277012165 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 745277012166 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 745277012167 TPP-binding site [chemical binding]; other site 745277012168 DNA cytosine methylase; Provisional; Region: PRK10458 745277012169 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 745277012170 cofactor binding site; other site 745277012171 DNA binding site [nucleotide binding] 745277012172 substrate interaction site [chemical binding]; other site 745277012173 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 745277012174 additional DNA contacts [nucleotide binding]; other site 745277012175 mismatch recognition site; other site 745277012176 active site 745277012177 zinc binding site [ion binding]; other site 745277012178 DNA intercalation site [nucleotide binding]; other site 745277012179 DNA binding domains of BfiI, EcoRII and plant B3 proteins; Region: BfiI_C_EcoRII_N_B3; cl15242 745277012180 DNA binding site [nucleotide binding] 745277012181 EcoRII C terminal; Region: EcoRII-C; pfam09019 745277012182 Transposase IS200 like; Region: Y1_Tnp; pfam01797 745277012183 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 745277012184 trimer interface [polypeptide binding]; other site 745277012185 eyelet of channel; other site 745277012186 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 745277012187 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 745277012188 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 745277012189 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 745277012190 active site 745277012191 Beta protein; Region: Beta_protein; pfam14350 745277012192 Ogr/Delta-like zinc finger; Region: Ogr_Delta; cl19592 745277012193 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 745277012194 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 745277012195 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 745277012196 multifunctional aminopeptidase A; Provisional; Region: PRK00913 745277012197 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 745277012198 interface (dimer of trimers) [polypeptide binding]; other site 745277012199 Substrate-binding/catalytic site; other site 745277012200 Zn-binding sites [ion binding]; other site 745277012201 DNA polymerase III subunit chi; Validated; Region: PRK05728 745277012202 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 745277012203 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 745277012204 active site 745277012205 HIGH motif; other site 745277012206 KMSKS motif; other site 745277012207 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 745277012208 tRNA binding surface [nucleotide binding]; other site 745277012209 anticodon binding site; other site 745277012210 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 745277012211 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277012212 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277012213 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 745277012214 dimerization interface [polypeptide binding]; other site 745277012215 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 745277012216 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745277012217 Coenzyme A binding pocket [chemical binding]; other site 745277012218 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 745277012219 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 745277012220 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 745277012221 putative active site [active] 745277012222 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 745277012223 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 745277012224 active site turn [active] 745277012225 phosphorylation site [posttranslational modification] 745277012226 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 745277012227 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 745277012228 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 745277012229 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 745277012230 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 745277012231 active site 745277012232 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 745277012233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277012234 putative substrate translocation pore; other site 745277012235 RNase E inhibitor protein; Provisional; Region: PRK11191 745277012236 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 745277012237 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 745277012238 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 745277012239 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 745277012240 active site 745277012241 homodimer interface [polypeptide binding]; other site 745277012242 catalytic site [active] 745277012243 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 745277012244 arginine deiminase; Provisional; Region: PRK01388 745277012245 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 745277012246 putative substrate binding site [chemical binding]; other site 745277012247 nucleotide binding site [chemical binding]; other site 745277012248 nucleotide binding site [chemical binding]; other site 745277012249 homodimer interface [polypeptide binding]; other site 745277012250 ornithine carbamoyltransferase; Validated; Region: PRK02102 745277012251 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 745277012252 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 745277012253 Predicted membrane protein [Function unknown]; Region: COG1288 745277012254 Arginine repressor [Transcription]; Region: ArgR; COG1438 745277012255 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 745277012256 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 745277012257 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 745277012258 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 745277012259 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 745277012260 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 745277012261 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 745277012262 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 745277012263 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 745277012264 homotrimer interaction site [polypeptide binding]; other site 745277012265 putative active site [active] 745277012266 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 745277012267 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 745277012268 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 745277012269 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 745277012270 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 745277012271 Uncharacterized conserved protein [Function unknown]; Region: COG2308 745277012272 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 745277012273 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 745277012274 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 745277012275 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 745277012276 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 745277012277 Transcriptional regulators [Transcription]; Region: PurR; COG1609 745277012278 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745277012279 DNA binding site [nucleotide binding] 745277012280 domain linker motif; other site 745277012281 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 745277012282 putative dimerization interface [polypeptide binding]; other site 745277012283 putative ligand binding site [chemical binding]; other site 745277012284 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 745277012285 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 745277012286 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 745277012287 Walker A/P-loop; other site 745277012288 ATP binding site [chemical binding]; other site 745277012289 Q-loop/lid; other site 745277012290 ABC transporter signature motif; other site 745277012291 Walker B; other site 745277012292 D-loop; other site 745277012293 H-loop/switch region; other site 745277012294 TOBE domain; Region: TOBE_2; pfam08402 745277012295 beta-phosphoglucomutase; Region: bPGM; TIGR01990 745277012296 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 745277012297 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745277012298 motif II; other site 745277012299 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 745277012300 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 745277012301 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 745277012302 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 745277012303 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 745277012304 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 745277012305 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 745277012306 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 745277012307 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 745277012308 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 745277012309 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 745277012310 putative NAD(P) binding site [chemical binding]; other site 745277012311 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 745277012312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277012313 dimer interface [polypeptide binding]; other site 745277012314 conserved gate region; other site 745277012315 putative PBP binding loops; other site 745277012316 ABC-ATPase subunit interface; other site 745277012317 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 745277012318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277012319 dimer interface [polypeptide binding]; other site 745277012320 conserved gate region; other site 745277012321 putative PBP binding loops; other site 745277012322 ABC-ATPase subunit interface; other site 745277012323 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 745277012324 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 745277012325 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 745277012326 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 745277012327 active site 745277012328 homodimer interface [polypeptide binding]; other site 745277012329 catalytic site [active] 745277012330 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 745277012331 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 745277012332 galactarate dehydratase; Region: galactar-dH20; TIGR03248 745277012333 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 745277012334 altronate oxidoreductase; Provisional; Region: PRK03643 745277012335 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 745277012336 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 745277012337 glucuronate isomerase; Reviewed; Region: PRK02925 745277012338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277012339 D-galactonate transporter; Region: 2A0114; TIGR00893 745277012340 putative substrate translocation pore; other site 745277012341 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 745277012342 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745277012343 DNA-binding site [nucleotide binding]; DNA binding site 745277012344 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 745277012345 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 745277012346 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 745277012347 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 745277012348 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 745277012349 Predicted membrane protein [Function unknown]; Region: COG5393 745277012350 YqjK-like protein; Region: YqjK; pfam13997 745277012351 Predicted membrane protein [Function unknown]; Region: COG2259 745277012352 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 745277012353 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 745277012354 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 745277012355 putative dimer interface [polypeptide binding]; other site 745277012356 N-terminal domain interface [polypeptide binding]; other site 745277012357 putative substrate binding pocket (H-site) [chemical binding]; other site 745277012358 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277012359 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 745277012360 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 745277012361 dimerization interface [polypeptide binding]; other site 745277012362 Pirin-related protein [General function prediction only]; Region: COG1741 745277012363 Pirin; Region: Pirin; pfam02678 745277012364 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 745277012365 putative SAM binding site [chemical binding]; other site 745277012366 putative homodimer interface [polypeptide binding]; other site 745277012367 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 745277012368 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 745277012369 putative ligand binding site [chemical binding]; other site 745277012370 hypothetical protein; Reviewed; Region: PRK12497 745277012371 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 745277012372 dimer interface [polypeptide binding]; other site 745277012373 active site 745277012374 outer membrane lipoprotein; Provisional; Region: PRK11023 745277012375 BON domain; Region: BON; pfam04972 745277012376 BON domain; Region: BON; pfam04972 745277012377 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 745277012378 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 745277012379 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 745277012380 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 745277012381 putative active site [active] 745277012382 heme pocket [chemical binding]; other site 745277012383 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745277012384 dimer interface [polypeptide binding]; other site 745277012385 phosphorylation site [posttranslational modification] 745277012386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277012387 ATP binding site [chemical binding]; other site 745277012388 Mg2+ binding site [ion binding]; other site 745277012389 G-X-G motif; other site 745277012390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277012391 active site 745277012392 phosphorylation site [posttranslational modification] 745277012393 intermolecular recognition site; other site 745277012394 dimerization interface [polypeptide binding]; other site 745277012395 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 745277012396 putative binding surface; other site 745277012397 active site 745277012398 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 745277012399 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 745277012400 active site 745277012401 dimer interface [polypeptide binding]; other site 745277012402 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 745277012403 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 745277012404 active site 745277012405 FMN binding site [chemical binding]; other site 745277012406 substrate binding site [chemical binding]; other site 745277012407 3Fe-4S cluster binding site [ion binding]; other site 745277012408 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 745277012409 domain interface; other site 745277012410 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 745277012411 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 745277012412 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 745277012413 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 745277012414 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 745277012415 stringent starvation protein A; Provisional; Region: sspA; PRK09481 745277012416 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 745277012417 C-terminal domain interface [polypeptide binding]; other site 745277012418 putative GSH binding site (G-site) [chemical binding]; other site 745277012419 dimer interface [polypeptide binding]; other site 745277012420 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 745277012421 dimer interface [polypeptide binding]; other site 745277012422 N-terminal domain interface [polypeptide binding]; other site 745277012423 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 745277012424 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 745277012425 23S rRNA interface [nucleotide binding]; other site 745277012426 L3 interface [polypeptide binding]; other site 745277012427 Predicted ATPase [General function prediction only]; Region: COG1485 745277012428 hypothetical protein; Provisional; Region: PRK11677 745277012429 serine endoprotease; Provisional; Region: PRK10139 745277012430 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 745277012431 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 745277012432 protein binding site [polypeptide binding]; other site 745277012433 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 745277012434 protein binding site [polypeptide binding]; other site 745277012435 serine endoprotease; Provisional; Region: PRK10898 745277012436 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 745277012437 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 745277012438 protein binding site [polypeptide binding]; other site 745277012439 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 745277012440 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 745277012441 hinge; other site 745277012442 active site 745277012443 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 745277012444 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 745277012445 anti sigma factor interaction site; other site 745277012446 regulatory phosphorylation site [posttranslational modification]; other site 745277012447 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 745277012448 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 745277012449 mce related protein; Region: MCE; pfam02470 745277012450 conserved hypothetical integral membrane protein; Region: TIGR00056 745277012451 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 745277012452 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 745277012453 Walker A/P-loop; other site 745277012454 ATP binding site [chemical binding]; other site 745277012455 Q-loop/lid; other site 745277012456 ABC transporter signature motif; other site 745277012457 Walker B; other site 745277012458 D-loop; other site 745277012459 H-loop/switch region; other site 745277012460 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 745277012461 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 745277012462 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 745277012463 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 745277012464 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 745277012465 putative active site [active] 745277012466 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 745277012467 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 745277012468 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 745277012469 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 745277012470 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 745277012471 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 745277012472 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 745277012473 Walker A/P-loop; other site 745277012474 ATP binding site [chemical binding]; other site 745277012475 Q-loop/lid; other site 745277012476 ABC transporter signature motif; other site 745277012477 Walker B; other site 745277012478 D-loop; other site 745277012479 H-loop/switch region; other site 745277012480 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 745277012481 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 745277012482 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 745277012483 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 745277012484 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 745277012485 30S subunit binding site; other site 745277012486 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 745277012487 active site 745277012488 phosphorylation site [posttranslational modification] 745277012489 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 745277012490 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 745277012491 dimerization domain swap beta strand [polypeptide binding]; other site 745277012492 regulatory protein interface [polypeptide binding]; other site 745277012493 active site 745277012494 regulatory phosphorylation site [posttranslational modification]; other site 745277012495 putative frv operon regulatory protein; Provisional; Region: PRK09863 745277012496 HTH domain; Region: HTH_11; pfam08279 745277012497 Mga helix-turn-helix domain; Region: Mga; pfam05043 745277012498 PRD domain; Region: PRD; pfam00874 745277012499 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 745277012500 active site 745277012501 P-loop; other site 745277012502 phosphorylation site [posttranslational modification] 745277012503 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 745277012504 active site 745277012505 phosphorylation site [posttranslational modification] 745277012506 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 745277012507 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 745277012508 dihydroorotase; Provisional; Region: PRK09237 745277012509 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 745277012510 active site 745277012511 Domain of unknown function (DUF4310); Region: DUF4310; pfam14187 745277012512 Domain of unknown function (DUF4311); Region: DUF4311; cl11919 745277012513 Domain of unknown function (DUF4312); Region: DUF4312; cl11917 745277012514 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272 745277012515 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 745277012516 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 745277012517 Rnk N-terminus; Region: Rnk_N; pfam14760 745277012518 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 745277012519 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 745277012520 Cytochrome b562; Region: Cytochrom_B562; cl01546 745277012521 peptidase PmbA; Provisional; Region: PRK11040 745277012522 hypothetical protein; Provisional; Region: PRK05255 745277012523 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 745277012524 RNAase interaction site [polypeptide binding]; other site 745277012525 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 745277012526 active site 745277012527 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 745277012528 tetramerization interface [polypeptide binding]; other site 745277012529 NAD(P) binding site [chemical binding]; other site 745277012530 catalytic residues [active] 745277012531 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 745277012532 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 745277012533 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 745277012534 Fusaric acid resistance protein family; Region: FUSC; pfam04632 745277012535 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 745277012536 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 745277012537 HlyD family secretion protein; Region: HlyD_3; pfam13437 745277012538 efflux system membrane protein; Provisional; Region: PRK11594 745277012539 transcriptional regulator; Provisional; Region: PRK10632 745277012540 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277012541 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 745277012542 putative effector binding pocket; other site 745277012543 dimerization interface [polypeptide binding]; other site 745277012544 protease TldD; Provisional; Region: tldD; PRK10735 745277012545 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 745277012546 hypothetical protein; Provisional; Region: PRK10899 745277012547 Protein of unknown function; Region: DUF3971; pfam13116 745277012548 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 745277012549 ribonuclease G; Provisional; Region: PRK11712 745277012550 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 745277012551 homodimer interface [polypeptide binding]; other site 745277012552 oligonucleotide binding site [chemical binding]; other site 745277012553 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 745277012554 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 745277012555 active site 745277012556 dimer interface [polypeptide binding]; other site 745277012557 rod shape-determining protein MreD; Provisional; Region: PRK11060 745277012558 rod shape-determining protein MreC; Region: mreC; TIGR00219 745277012559 rod shape-determining protein MreB; Provisional; Region: PRK13927 745277012560 MreB and similar proteins; Region: MreB_like; cd10225 745277012561 nucleotide binding site [chemical binding]; other site 745277012562 Mg binding site [ion binding]; other site 745277012563 putative protofilament interaction site [polypeptide binding]; other site 745277012564 RodZ interaction site [polypeptide binding]; other site 745277012565 regulatory protein CsrD; Provisional; Region: PRK11059 745277012566 diguanylate cyclase; Region: GGDEF; smart00267 745277012567 nucleotidyl binding site; other site 745277012568 metal binding site [ion binding]; metal-binding site 745277012569 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 745277012570 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 745277012571 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 745277012572 Moco binding site; other site 745277012573 metal coordination site [ion binding]; other site 745277012574 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 745277012575 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 745277012576 active site 745277012577 trimer interface [polypeptide binding]; other site 745277012578 dimer interface [polypeptide binding]; other site 745277012579 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 745277012580 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 745277012581 carboxyltransferase (CT) interaction site; other site 745277012582 biotinylation site [posttranslational modification]; other site 745277012583 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 745277012584 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 745277012585 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 745277012586 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 745277012587 Peptidase M60-like family; Region: M60-like; cl19940 745277012588 hypothetical protein; Provisional; Region: PRK10633 745277012589 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 745277012590 Na binding site [ion binding]; other site 745277012591 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 745277012592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277012593 S-adenosylmethionine binding site [chemical binding]; other site 745277012594 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 745277012595 active site 745277012596 zinc binding site [ion binding]; other site 745277012597 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 745277012598 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 745277012599 FMN binding site [chemical binding]; other site 745277012600 active site 745277012601 catalytic residues [active] 745277012602 substrate binding site [chemical binding]; other site 745277012603 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 745277012604 Predicted membrane protein [Function unknown]; Region: COG2259 745277012605 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 745277012606 putative acyl-acceptor binding pocket; other site 745277012607 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 745277012608 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745277012609 substrate binding pocket [chemical binding]; other site 745277012610 membrane-bound complex binding site; other site 745277012611 hinge residues; other site 745277012612 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 745277012613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 745277012614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277012615 dimer interface [polypeptide binding]; other site 745277012616 conserved gate region; other site 745277012617 putative PBP binding loops; other site 745277012618 ABC-ATPase subunit interface; other site 745277012619 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 745277012620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277012621 dimer interface [polypeptide binding]; other site 745277012622 conserved gate region; other site 745277012623 putative PBP binding loops; other site 745277012624 ABC-ATPase subunit interface; other site 745277012625 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 745277012626 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 745277012627 Walker A/P-loop; other site 745277012628 ATP binding site [chemical binding]; other site 745277012629 Q-loop/lid; other site 745277012630 ABC transporter signature motif; other site 745277012631 Walker B; other site 745277012632 D-loop; other site 745277012633 H-loop/switch region; other site 745277012634 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 745277012635 LrgA family; Region: LrgA; cl00608 745277012636 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277012637 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277012638 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 745277012639 putative dimerization interface [polypeptide binding]; other site 745277012640 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 745277012641 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 745277012642 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 745277012643 Sulfate transporter family; Region: Sulfate_transp; cl19250 745277012644 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 745277012645 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 745277012646 putative C-terminal domain interface [polypeptide binding]; other site 745277012647 putative GSH binding site (G-site) [chemical binding]; other site 745277012648 putative dimer interface [polypeptide binding]; other site 745277012649 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 745277012650 putative N-terminal domain interface [polypeptide binding]; other site 745277012651 putative dimer interface [polypeptide binding]; other site 745277012652 putative substrate binding pocket (H-site) [chemical binding]; other site 745277012653 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 745277012654 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 745277012655 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 745277012656 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745277012657 metal binding site [ion binding]; metal-binding site 745277012658 active site 745277012659 I-site; other site 745277012660 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 745277012661 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 745277012662 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 745277012663 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 745277012664 dimer interface [polypeptide binding]; other site 745277012665 putative CheW interface [polypeptide binding]; other site 745277012666 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 745277012667 active site 745277012668 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 745277012669 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 745277012670 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 745277012671 putative ligand binding residues [chemical binding]; other site 745277012672 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 745277012673 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 745277012674 ATP binding site [chemical binding]; other site 745277012675 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745277012676 Male sterility protein; Region: NAD_binding_4; pfam07993 745277012677 NAD(P) binding site [chemical binding]; other site 745277012678 active site 745277012679 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 745277012680 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 745277012681 putative C-terminal domain interface [polypeptide binding]; other site 745277012682 putative GSH binding site (G-site) [chemical binding]; other site 745277012683 putative dimer interface [polypeptide binding]; other site 745277012684 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 745277012685 putative N-terminal domain interface [polypeptide binding]; other site 745277012686 putative dimer interface [polypeptide binding]; other site 745277012687 putative substrate binding pocket (H-site) [chemical binding]; other site 745277012688 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 745277012689 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277012690 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 745277012691 EamA-like transporter family; Region: EamA; pfam00892 745277012692 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 745277012693 Tautomerase enzyme; Region: Tautomerase_2; pfam14552 745277012694 active site 1 [active] 745277012695 dimer interface [polypeptide binding]; other site 745277012696 hexamer interface [polypeptide binding]; other site 745277012697 active site 2 [active] 745277012698 PemK-like protein; Region: PemK; cl00995 745277012699 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 745277012700 short chain dehydrogenase; Provisional; Region: PRK12937 745277012701 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 745277012702 NADP binding site [chemical binding]; other site 745277012703 homodimer interface [polypeptide binding]; other site 745277012704 active site 745277012705 substrate binding site [chemical binding]; other site 745277012706 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277012707 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277012708 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 745277012709 putative effector binding pocket; other site 745277012710 putative dimerization interface [polypeptide binding]; other site 745277012711 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 745277012712 salicylate hydroxylase; Provisional; Region: PRK08163 745277012713 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 745277012714 Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; cl04145 745277012715 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277012716 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277012717 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 745277012718 dimerization interface [polypeptide binding]; other site 745277012719 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 745277012720 cytosine deaminase; Provisional; Region: PRK05985 745277012721 active site 745277012722 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 745277012723 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 745277012724 dimer interface [polypeptide binding]; other site 745277012725 ssDNA binding site [nucleotide binding]; other site 745277012726 tetramer (dimer of dimers) interface [polypeptide binding]; other site 745277012727 putative single-stranded DNA-binding protein; Region: PHA01740 745277012728 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 745277012729 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 745277012730 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 745277012731 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 745277012732 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 745277012733 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 745277012734 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 745277012735 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277012736 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277012737 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 745277012738 putative effector binding pocket; other site 745277012739 putative dimerization interface [polypeptide binding]; other site 745277012740 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 745277012741 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 745277012742 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 745277012743 putative N-terminal domain interface [polypeptide binding]; other site 745277012744 putative dimer interface [polypeptide binding]; other site 745277012745 putative substrate binding pocket (H-site) [chemical binding]; other site 745277012746 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 745277012747 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 745277012748 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 745277012749 Uncharacterized conserved protein [Function unknown]; Region: COG0432 745277012750 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 745277012751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277012752 putative substrate translocation pore; other site 745277012753 putative symporter YagG; Provisional; Region: PRK09669; cl15392 745277012754 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 745277012755 alpha-glucosidase; Provisional; Region: PRK10426 745277012756 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 745277012757 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 745277012758 putative active site [active] 745277012759 putative catalytic site [active] 745277012760 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 745277012761 dimerization interface [polypeptide binding]; other site 745277012762 putative active cleft [active] 745277012763 Class I aldolases; Region: Aldolase_Class_I; cl17187 745277012764 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 745277012765 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 745277012766 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 745277012767 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 745277012768 substrate binding site [chemical binding]; other site 745277012769 ATP binding site [chemical binding]; other site 745277012770 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 745277012771 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 745277012772 putative DNA binding site [nucleotide binding]; other site 745277012773 putative Zn2+ binding site [ion binding]; other site 745277012774 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 745277012775 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 745277012776 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 745277012777 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277012778 homodimer interface [polypeptide binding]; other site 745277012779 catalytic residue [active] 745277012780 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 745277012781 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745277012782 NAD(P) binding site [chemical binding]; other site 745277012783 active site 745277012784 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 745277012785 Uncharacterized conserved protein [Function unknown]; Region: COG1284 745277012786 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 745277012787 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 745277012788 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 745277012789 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745277012790 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 745277012791 substrate binding pocket [chemical binding]; other site 745277012792 membrane-bound complex binding site; other site 745277012793 hinge residues; other site 745277012794 alanine racemase; Reviewed; Region: alr; PRK00053 745277012795 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 745277012796 active site 745277012797 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 745277012798 substrate binding site [chemical binding]; other site 745277012799 catalytic residues [active] 745277012800 dimer interface [polypeptide binding]; other site 745277012801 replicative DNA helicase; Provisional; Region: PRK08006 745277012802 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 745277012803 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 745277012804 Walker A motif; other site 745277012805 ATP binding site [chemical binding]; other site 745277012806 Walker B motif; other site 745277012807 DNA binding loops [nucleotide binding] 745277012808 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 745277012809 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 745277012810 NADP binding site [chemical binding]; other site 745277012811 dimer interface [polypeptide binding]; other site 745277012812 phage shock protein G; Reviewed; Region: pspG; PRK09459 745277012813 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 745277012814 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 745277012815 FMN binding site [chemical binding]; other site 745277012816 active site 745277012817 catalytic residues [active] 745277012818 substrate binding site [chemical binding]; other site 745277012819 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 745277012820 metal binding site 2 [ion binding]; metal-binding site 745277012821 putative DNA binding helix; other site 745277012822 metal binding site 1 [ion binding]; metal-binding site 745277012823 dimer interface [polypeptide binding]; other site 745277012824 structural Zn2+ binding site [ion binding]; other site 745277012825 hypothetical protein; Provisional; Region: PRK10428 745277012826 LexA repressor; Validated; Region: PRK00215 745277012827 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 745277012828 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 745277012829 Catalytic site [active] 745277012830 Integral membrane diacylglycerol kinase; Region: DAGK_IM; cd14264 745277012831 putative active site [active] 745277012832 trimer interface [polypeptide binding]; other site 745277012833 putative active site [active] 745277012834 Zn binding site [ion binding]; other site 745277012835 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 745277012836 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 745277012837 putative acyl-acceptor binding pocket; other site 745277012838 4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959 745277012839 putative active site [active] 745277012840 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 745277012841 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 745277012842 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 745277012843 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 745277012844 active site 745277012845 dimer interface [polypeptide binding]; other site 745277012846 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 745277012847 dimer interface [polypeptide binding]; other site 745277012848 active site 745277012849 aspartate kinase III; Validated; Region: PRK09084 745277012850 AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some...; Region: AAK_AKiii-LysC-EC; cd04258 745277012851 nucleotide binding site [chemical binding]; other site 745277012852 putative catalytic residues [active] 745277012853 aspartate binding site [chemical binding]; other site 745277012854 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 745277012855 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 745277012856 dimer interface [polypeptide binding]; other site 745277012857 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 745277012858 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 745277012859 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 745277012860 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 745277012861 PhoU domain; Region: PhoU; pfam01895 745277012862 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 745277012863 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 745277012864 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 745277012865 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745277012866 Walker A/P-loop; other site 745277012867 ATP binding site [chemical binding]; other site 745277012868 Q-loop/lid; other site 745277012869 ABC transporter signature motif; other site 745277012870 Walker B; other site 745277012871 D-loop; other site 745277012872 H-loop/switch region; other site 745277012873 TOBE domain; Region: TOBE_2; pfam08402 745277012874 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 745277012875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277012876 dimer interface [polypeptide binding]; other site 745277012877 conserved gate region; other site 745277012878 putative PBP binding loops; other site 745277012879 ABC-ATPase subunit interface; other site 745277012880 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 745277012881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 745277012882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277012883 putative PBP binding loops; other site 745277012884 dimer interface [polypeptide binding]; other site 745277012885 ABC-ATPase subunit interface; other site 745277012886 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 745277012887 Sulfatase; Region: Sulfatase; cl19157 745277012888 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 745277012889 transcriptional regulator protein; Region: phnR; TIGR03337 745277012890 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745277012891 DNA-binding site [nucleotide binding]; DNA binding site 745277012892 UTRA domain; Region: UTRA; pfam07702 745277012893 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 745277012894 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 745277012895 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 745277012896 substrate binding pocket [chemical binding]; other site 745277012897 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 745277012898 B12 binding site [chemical binding]; other site 745277012899 cobalt ligand [ion binding]; other site 745277012900 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 745277012901 transcriptional repressor IclR; Provisional; Region: PRK11569 745277012902 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 745277012903 Bacterial transcriptional regulator; Region: IclR; pfam01614 745277012904 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 745277012905 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 745277012906 tetramer interface [polypeptide binding]; other site 745277012907 active site 745277012908 Mg2+/Mn2+ binding site [ion binding]; other site 745277012909 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 745277012910 active site 745277012911 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 745277012912 proposed active site lysine [active] 745277012913 conserved cys residue [active] 745277012914 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 745277012915 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 745277012916 purine monophosphate binding site [chemical binding]; other site 745277012917 dimer interface [polypeptide binding]; other site 745277012918 putative catalytic residues [active] 745277012919 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 745277012920 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 745277012921 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 745277012922 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 745277012923 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 745277012924 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 745277012925 histone-like DNA-binding protein HU; Region: HU; cd13831 745277012926 dimer interface [polypeptide binding]; other site 745277012927 DNA binding site [nucleotide binding] 745277012928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 745277012929 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 745277012930 Active_site [active] 745277012931 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 745277012932 substrate binding site [chemical binding]; other site 745277012933 active site 745277012934 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 745277012935 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 745277012936 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 745277012937 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 745277012938 putative NADH binding site [chemical binding]; other site 745277012939 putative active site [active] 745277012940 nudix motif; other site 745277012941 putative metal binding site [ion binding]; other site 745277012942 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 745277012943 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 745277012944 ThiC-associated domain; Region: ThiC-associated; pfam13667 745277012945 ThiC family; Region: ThiC; pfam01964 745277012946 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 745277012947 thiamine phosphate binding site [chemical binding]; other site 745277012948 active site 745277012949 pyrophosphate binding site [ion binding]; other site 745277012950 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 745277012951 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 745277012952 ATP binding site [chemical binding]; other site 745277012953 substrate interface [chemical binding]; other site 745277012954 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 745277012955 thiS-thiF/thiG interaction site; other site 745277012956 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 745277012957 ThiS interaction site; other site 745277012958 putative active site [active] 745277012959 tetramer interface [polypeptide binding]; other site 745277012960 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 745277012961 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 745277012962 FeS/SAM binding site; other site 745277012963 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 745277012964 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 745277012965 beta and beta' interface [polypeptide binding]; other site 745277012966 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 745277012967 beta' and sigma factor interface [polypeptide binding]; other site 745277012968 Zn-binding [ion binding]; other site 745277012969 active site region [active] 745277012970 catalytic site [active] 745277012971 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 745277012972 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 745277012973 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 745277012974 G-loop; other site 745277012975 DNA binding site [nucleotide binding] 745277012976 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 745277012977 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 745277012978 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 745277012979 RPB12 interaction site [polypeptide binding]; other site 745277012980 RPB1 interaction site [polypeptide binding]; other site 745277012981 RPB10 interaction site [polypeptide binding]; other site 745277012982 RPB11 interaction site [polypeptide binding]; other site 745277012983 RPB3 interaction site [polypeptide binding]; other site 745277012984 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 745277012985 core dimer interface [polypeptide binding]; other site 745277012986 peripheral dimer interface [polypeptide binding]; other site 745277012987 L10 interface [polypeptide binding]; other site 745277012988 L11 interface [polypeptide binding]; other site 745277012989 putative EF-Tu interaction site [polypeptide binding]; other site 745277012990 putative EF-G interaction site [polypeptide binding]; other site 745277012991 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 745277012992 23S rRNA interface [nucleotide binding]; other site 745277012993 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 745277012994 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 745277012995 mRNA/rRNA interface [nucleotide binding]; other site 745277012996 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 745277012997 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 745277012998 23S rRNA interface [nucleotide binding]; other site 745277012999 L7/L12 interface [polypeptide binding]; other site 745277013000 putative thiostrepton binding site; other site 745277013001 L25 interface [polypeptide binding]; other site 745277013002 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 745277013003 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 745277013004 putative homodimer interface [polypeptide binding]; other site 745277013005 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 745277013006 heterodimer interface [polypeptide binding]; other site 745277013007 homodimer interface [polypeptide binding]; other site 745277013008 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 745277013009 elongation factor Tu; Reviewed; Region: PRK00049 745277013010 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 745277013011 G1 box; other site 745277013012 GEF interaction site [polypeptide binding]; other site 745277013013 GTP/Mg2+ binding site [chemical binding]; other site 745277013014 Switch I region; other site 745277013015 G2 box; other site 745277013016 G3 box; other site 745277013017 Switch II region; other site 745277013018 G4 box; other site 745277013019 G5 box; other site 745277013020 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 745277013021 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 745277013022 Antibiotic Binding Site [chemical binding]; other site 745277013023 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 745277013024 ATP-binding site [chemical binding]; other site 745277013025 CoA-binding site [chemical binding]; other site 745277013026 Mg2+-binding site [ion binding]; other site 745277013027 Biotin operon repressor [Transcription]; Region: BirA; COG1654 745277013028 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 745277013029 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 745277013030 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 745277013031 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 745277013032 FAD binding domain; Region: FAD_binding_4; pfam01565 745277013033 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 745277013034 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 745277013035 potassium transporter; Provisional; Region: PRK10750 745277013036 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 745277013037 hypothetical protein; Provisional; Region: PRK11568 745277013038 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 745277013039 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 745277013040 proline dipeptidase; Provisional; Region: PRK13607 745277013041 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 745277013042 active site 745277013043 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 745277013044 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 745277013045 substrate binding site [chemical binding]; other site 745277013046 oxyanion hole (OAH) forming residues; other site 745277013047 trimer interface [polypeptide binding]; other site 745277013048 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 745277013049 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 745277013050 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 745277013051 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 745277013052 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 745277013053 dimer interface [polypeptide binding]; other site 745277013054 active site 745277013055 FMN reductase; Validated; Region: fre; PRK08051 745277013056 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 745277013057 FAD binding pocket [chemical binding]; other site 745277013058 FAD binding motif [chemical binding]; other site 745277013059 phosphate binding motif [ion binding]; other site 745277013060 beta-alpha-beta structure motif; other site 745277013061 NAD binding pocket [chemical binding]; other site 745277013062 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 745277013063 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 745277013064 active site pocket [active] 745277013065 oxyanion hole [active] 745277013066 catalytic triad [active] 745277013067 active site nucleophile [active] 745277013068 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 745277013069 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 745277013070 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 745277013071 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 745277013072 active site 745277013073 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 745277013074 sec-independent translocase; Provisional; Region: PRK04654 745277013075 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 745277013076 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 745277013077 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 745277013078 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 745277013079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 745277013080 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 745277013081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277013082 S-adenosylmethionine binding site [chemical binding]; other site 745277013083 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 745277013084 DNA recombination protein RmuC; Provisional; Region: PRK10361 745277013085 RmuC family; Region: RmuC; pfam02646 745277013086 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 745277013087 uridine phosphorylase; Provisional; Region: PRK11178 745277013088 hydroperoxidase II; Provisional; Region: katE; PRK11249 745277013089 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 745277013090 tetramer interface [polypeptide binding]; other site 745277013091 heme binding pocket [chemical binding]; other site 745277013092 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 745277013093 domain interactions; other site 745277013094 Dienelactone hydrolase family; Region: DLH; pfam01738 745277013095 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 745277013096 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 745277013097 active site 745277013098 intersubunit interactions; other site 745277013099 catalytic residue [active] 745277013100 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 745277013101 dimerization domain swap beta strand [polypeptide binding]; other site 745277013102 regulatory protein interface [polypeptide binding]; other site 745277013103 active site 745277013104 regulatory phosphorylation site [posttranslational modification]; other site 745277013105 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 745277013106 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 745277013107 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 745277013108 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 745277013109 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 745277013110 active site 745277013111 phosphorylation site [posttranslational modification] 745277013112 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 745277013113 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 745277013114 active site 745277013115 P-loop; other site 745277013116 phosphorylation site [posttranslational modification] 745277013117 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 745277013118 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 745277013119 dimer interface [polypeptide binding]; other site 745277013120 active site 745277013121 glycine loop; other site 745277013122 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 745277013123 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 745277013124 FeS/SAM binding site; other site 745277013125 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 745277013126 active site 745277013127 P-loop; other site 745277013128 phosphorylation site [posttranslational modification] 745277013129 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 745277013130 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 745277013131 THF binding site; other site 745277013132 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 745277013133 substrate binding site [chemical binding]; other site 745277013134 THF binding site; other site 745277013135 zinc-binding site [ion binding]; other site 745277013136 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 745277013137 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277013138 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 745277013139 putative dimerization interface [polypeptide binding]; other site 745277013140 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 745277013141 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 745277013142 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 745277013143 putative active site [active] 745277013144 catalytic site [active] 745277013145 putative metal binding site [ion binding]; other site 745277013146 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 745277013147 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 745277013148 Walker A/P-loop; other site 745277013149 ATP binding site [chemical binding]; other site 745277013150 Q-loop/lid; other site 745277013151 ABC transporter signature motif; other site 745277013152 Walker B; other site 745277013153 D-loop; other site 745277013154 H-loop/switch region; other site 745277013155 TOBE domain; Region: TOBE_2; pfam08402 745277013156 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 745277013157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277013158 dimer interface [polypeptide binding]; other site 745277013159 conserved gate region; other site 745277013160 putative PBP binding loops; other site 745277013161 ABC-ATPase subunit interface; other site 745277013162 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 745277013163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277013164 dimer interface [polypeptide binding]; other site 745277013165 conserved gate region; other site 745277013166 putative PBP binding loops; other site 745277013167 ABC-ATPase subunit interface; other site 745277013168 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 745277013169 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 745277013170 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 745277013171 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 745277013172 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277013173 homodimer interface [polypeptide binding]; other site 745277013174 catalytic residue [active] 745277013175 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 745277013176 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 745277013177 Walker A/P-loop; other site 745277013178 ATP binding site [chemical binding]; other site 745277013179 Q-loop/lid; other site 745277013180 ABC transporter signature motif; other site 745277013181 Walker B; other site 745277013182 D-loop; other site 745277013183 H-loop/switch region; other site 745277013184 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 745277013185 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 745277013186 Walker A/P-loop; other site 745277013187 ATP binding site [chemical binding]; other site 745277013188 Q-loop/lid; other site 745277013189 ABC transporter signature motif; other site 745277013190 Walker B; other site 745277013191 D-loop; other site 745277013192 H-loop/switch region; other site 745277013193 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 745277013194 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 745277013195 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 745277013196 TM-ABC transporter signature motif; other site 745277013197 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 745277013198 TM-ABC transporter signature motif; other site 745277013199 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 745277013200 dimerization interface [polypeptide binding]; other site 745277013201 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 745277013202 ligand binding site [chemical binding]; other site 745277013203 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745277013204 RecX family; Region: RecX; cl00936 745277013205 Coenzyme A binding pocket [chemical binding]; other site 745277013206 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 745277013207 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 745277013208 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 745277013209 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 745277013210 DNA binding residues [nucleotide binding] 745277013211 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 745277013212 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 745277013213 cell division protein FtsE; Provisional; Region: PRK10908 745277013214 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 745277013215 Walker A/P-loop; other site 745277013216 ATP binding site [chemical binding]; other site 745277013217 Q-loop/lid; other site 745277013218 ABC transporter signature motif; other site 745277013219 Walker B; other site 745277013220 D-loop; other site 745277013221 H-loop/switch region; other site 745277013222 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 745277013223 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 745277013224 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 745277013225 P loop; other site 745277013226 GTP binding site [chemical binding]; other site 745277013227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277013228 S-adenosylmethionine binding site [chemical binding]; other site 745277013229 hypothetical protein; Provisional; Region: PRK10910 745277013230 Predicted membrane protein [Function unknown]; Region: COG3714 745277013231 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 745277013232 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 745277013233 metal-binding site [ion binding] 745277013234 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 745277013235 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745277013236 motif II; other site 745277013237 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 745277013238 CPxP motif; other site 745277013239 hypothetical protein; Provisional; Region: PRK11212 745277013240 hypothetical protein; Provisional; Region: PRK11615 745277013241 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 745277013242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277013243 putative substrate translocation pore; other site 745277013244 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 745277013245 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 745277013246 Walker A/P-loop; other site 745277013247 ATP binding site [chemical binding]; other site 745277013248 Q-loop/lid; other site 745277013249 ABC transporter signature motif; other site 745277013250 Walker B; other site 745277013251 D-loop; other site 745277013252 H-loop/switch region; other site 745277013253 TOBE domain; Region: TOBE_2; pfam08402 745277013254 phosphomannomutase CpsG; Provisional; Region: PRK15414 745277013255 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 745277013256 active site 745277013257 substrate binding site [chemical binding]; other site 745277013258 metal binding site [ion binding]; metal-binding site 745277013259 Transcriptional regulators [Transcription]; Region: PurR; COG1609 745277013260 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745277013261 DNA binding site [nucleotide binding] 745277013262 domain linker motif; other site 745277013263 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 745277013264 putative dimerization interface [polypeptide binding]; other site 745277013265 putative ligand binding site [chemical binding]; other site 745277013266 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 745277013267 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 745277013268 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 745277013269 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277013270 dimer interface [polypeptide binding]; other site 745277013271 putative PBP binding loops; other site 745277013272 ABC-ATPase subunit interface; other site 745277013273 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 745277013274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277013275 dimer interface [polypeptide binding]; other site 745277013276 conserved gate region; other site 745277013277 putative PBP binding loops; other site 745277013278 ABC-ATPase subunit interface; other site 745277013279 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 745277013280 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 745277013281 active site 745277013282 catalytic site [active] 745277013283 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 745277013284 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 745277013285 active site 745277013286 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 745277013287 Porin subfamily; Region: Porin_2; pfam02530 745277013288 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 745277013289 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 745277013290 Surface antigen; Region: Bac_surface_Ag; pfam01103 745277013291 haemagglutination activity domain; Region: Haemagg_act; pfam05860 745277013292 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 745277013293 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 745277013294 putative hydrolase; Provisional; Region: PRK10976 745277013295 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745277013296 active site 745277013297 motif I; other site 745277013298 motif II; other site 745277013299 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 745277013300 lysophospholipase L2; Provisional; Region: PRK10749 745277013301 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 745277013302 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 745277013303 threonine efflux system; Provisional; Region: PRK10229 745277013304 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 745277013305 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 745277013306 ATP binding site [chemical binding]; other site 745277013307 putative Mg++ binding site [ion binding]; other site 745277013308 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 745277013309 nucleotide binding region [chemical binding]; other site 745277013310 ATP-binding site [chemical binding]; other site 745277013311 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 745277013312 HRDC domain; Region: HRDC; pfam00570 745277013313 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 745277013314 dimerization interface [polypeptide binding]; other site 745277013315 substrate binding site [chemical binding]; other site 745277013316 active site 745277013317 calcium binding site [ion binding]; other site 745277013318 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 745277013319 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 745277013320 CoenzymeA binding site [chemical binding]; other site 745277013321 subunit interaction site [polypeptide binding]; other site 745277013322 PHB binding site; other site 745277013323 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 745277013324 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 745277013325 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 745277013326 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 745277013327 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 745277013328 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 745277013329 Cl binding site [ion binding]; other site 745277013330 oligomer interface [polypeptide binding]; other site 745277013331 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 745277013332 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 745277013333 Part of AAA domain; Region: AAA_19; pfam13245 745277013334 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 745277013335 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 745277013336 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745277013337 motif II; other site 745277013338 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 745277013339 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 745277013340 active site 745277013341 Int/Topo IB signature motif; other site 745277013342 hypothetical protein; Provisional; Region: PRK10963 745277013343 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 745277013344 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 745277013345 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 745277013346 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 745277013347 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 745277013348 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 745277013349 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 745277013350 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 745277013351 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 745277013352 domain interfaces; other site 745277013353 active site 745277013354 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 745277013355 active site 745277013356 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 745277013357 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 745277013358 HemY protein N-terminus; Region: HemY_N; pfam07219 745277013359 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 745277013360 TPR motif; other site 745277013361 binding surface 745277013362 putative transport protein YifK; Provisional; Region: PRK10746 745277013363 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 745277013364 putative common antigen polymerase; Provisional; Region: PRK02975 745277013365 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 745277013366 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 745277013367 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 745277013368 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 745277013369 inhibitor-cofactor binding pocket; inhibition site 745277013370 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277013371 catalytic residue [active] 745277013372 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; cl19828 745277013373 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 745277013374 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745277013375 Coenzyme A binding pocket [chemical binding]; other site 745277013376 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 745277013377 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 745277013378 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 745277013379 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 745277013380 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 745277013381 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 745277013382 active site 745277013383 homodimer interface [polypeptide binding]; other site 745277013384 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 745277013385 Chain length determinant protein; Region: Wzz; pfam02706 745277013386 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 745277013387 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 745277013388 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 745277013389 Mg++ binding site [ion binding]; other site 745277013390 putative catalytic motif [active] 745277013391 substrate binding site [chemical binding]; other site 745277013392 transcription termination factor Rho; Provisional; Region: rho; PRK09376 745277013393 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 745277013394 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 745277013395 RNA binding site [nucleotide binding]; other site 745277013396 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 745277013397 multimer interface [polypeptide binding]; other site 745277013398 Walker A motif; other site 745277013399 ATP binding site [chemical binding]; other site 745277013400 Walker B motif; other site 745277013401 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 745277013402 catalytic residues [active] 745277013403 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 745277013404 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 745277013405 ATP binding site [chemical binding]; other site 745277013406 Mg++ binding site [ion binding]; other site 745277013407 motif III; other site 745277013408 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 745277013409 nucleotide binding region [chemical binding]; other site 745277013410 ATP-binding site [chemical binding]; other site 745277013411 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 745277013412 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 745277013413 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 745277013414 Part of AAA domain; Region: AAA_19; pfam13245 745277013415 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 745277013416 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 745277013417 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 745277013418 ketol-acid reductoisomerase; Validated; Region: PRK05225 745277013419 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 745277013420 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 745277013421 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277013422 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 745277013423 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 745277013424 putative dimerization interface [polypeptide binding]; other site 745277013425 threonine dehydratase; Reviewed; Region: PRK09224 745277013426 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 745277013427 tetramer interface [polypeptide binding]; other site 745277013428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277013429 catalytic residue [active] 745277013430 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 745277013431 putative Ile/Val binding site [chemical binding]; other site 745277013432 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 745277013433 putative Ile/Val binding site [chemical binding]; other site 745277013434 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 745277013435 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 745277013436 homodimer interface [polypeptide binding]; other site 745277013437 substrate-cofactor binding pocket; other site 745277013438 catalytic residue [active] 745277013439 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 745277013440 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 745277013441 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 745277013442 PYR/PP interface [polypeptide binding]; other site 745277013443 dimer interface [polypeptide binding]; other site 745277013444 TPP binding site [chemical binding]; other site 745277013445 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 745277013446 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 745277013447 TPP-binding site [chemical binding]; other site 745277013448 dimer interface [polypeptide binding]; other site 745277013449 IlvGEDA operon leader peptide; Region: IlvGEDA_leader; pfam08046 745277013450 putative sialic acid transporter; Region: 2A0112; TIGR00891 745277013451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277013452 putative substrate translocation pore; other site 745277013453 putative ATP-dependent protease; Provisional; Region: PRK09862 745277013454 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 745277013455 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745277013456 Walker A motif; other site 745277013457 ATP binding site [chemical binding]; other site 745277013458 Walker B motif; other site 745277013459 arginine finger; other site 745277013460 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 745277013461 hypothetical protein; Provisional; Region: PRK11027 745277013462 transcriptional regulator HdfR; Provisional; Region: PRK03601 745277013463 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277013464 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 745277013465 dimerization interface [polypeptide binding]; other site 745277013466 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 745277013467 TM-ABC transporter signature motif; other site 745277013468 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 745277013469 TM-ABC transporter signature motif; other site 745277013470 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 745277013471 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 745277013472 Walker A/P-loop; other site 745277013473 ATP binding site [chemical binding]; other site 745277013474 Q-loop/lid; other site 745277013475 ABC transporter signature motif; other site 745277013476 Walker B; other site 745277013477 D-loop; other site 745277013478 H-loop/switch region; other site 745277013479 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 745277013480 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 745277013481 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 745277013482 putative ligand binding site [chemical binding]; other site 745277013483 glutamate racemase; Provisional; Region: PRK00865 745277013484 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 745277013485 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 745277013486 N-terminal plug; other site 745277013487 ligand-binding site [chemical binding]; other site 745277013488 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 745277013489 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277013490 S-adenosylmethionine binding site [chemical binding]; other site 745277013491 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 745277013492 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 745277013493 putative symporter YagG; Provisional; Region: PRK09669; cl15392 745277013494 hypothetical protein; Provisional; Region: PRK11056 745277013495 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 745277013496 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745277013497 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 745277013498 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 745277013499 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 745277013500 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 745277013501 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 745277013502 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277013503 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 745277013504 dimerization interface [polypeptide binding]; other site 745277013505 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 745277013506 catalytic triad [active] 745277013507 dimer interface [polypeptide binding]; other site 745277013508 Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029 745277013509 GSH binding site [chemical binding]; other site 745277013510 catalytic residues [active] 745277013511 argininosuccinate lyase; Provisional; Region: PRK04833 745277013512 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 745277013513 active sites [active] 745277013514 tetramer interface [polypeptide binding]; other site 745277013515 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 745277013516 nucleotide binding site [chemical binding]; other site 745277013517 substrate binding site [chemical binding]; other site 745277013518 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 745277013519 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 745277013520 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935 745277013521 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 745277013522 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 745277013523 metal binding site [ion binding]; metal-binding site 745277013524 putative dimer interface [polypeptide binding]; other site 745277013525 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 745277013526 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 745277013527 FAD binding site [chemical binding]; other site 745277013528 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 745277013529 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 745277013530 putative catalytic residues [active] 745277013531 putative nucleotide binding site [chemical binding]; other site 745277013532 putative aspartate binding site [chemical binding]; other site 745277013533 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 745277013534 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 745277013535 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 745277013536 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 745277013537 homodimer interface [polypeptide binding]; other site 745277013538 substrate-cofactor binding pocket; other site 745277013539 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277013540 catalytic residue [active] 745277013541 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 745277013542 dimerization interface [polypeptide binding]; other site 745277013543 DNA binding site [nucleotide binding] 745277013544 corepressor binding sites; other site 745277013545 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 745277013546 primosome assembly protein PriA; Validated; Region: PRK05580 745277013547 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 745277013548 ATP binding site [chemical binding]; other site 745277013549 putative Mg++ binding site [ion binding]; other site 745277013550 helicase superfamily c-terminal domain; Region: HELICc; smart00490 745277013551 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745277013552 DNA binding site [nucleotide binding] 745277013553 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 745277013554 domain linker motif; other site 745277013555 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 745277013556 dimerization interface [polypeptide binding]; other site 745277013557 ligand binding site [chemical binding]; other site 745277013558 cell division protein FtsN; Provisional; Region: PRK12757 745277013559 Sporulation related domain; Region: SPOR; pfam05036 745277013560 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 745277013561 active site 745277013562 HslU subunit interaction site [polypeptide binding]; other site 745277013563 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 745277013564 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745277013565 Walker A motif; other site 745277013566 ATP binding site [chemical binding]; other site 745277013567 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745277013568 Walker B motif; other site 745277013569 arginine finger; other site 745277013570 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 745277013571 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 745277013572 putative active site [active] 745277013573 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 745277013574 Protein of unknown function (DUF904); Region: DUF904; cl11531 745277013575 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 745277013576 amphipathic channel; other site 745277013577 Asn-Pro-Ala signature motifs; other site 745277013578 glycerol kinase; Provisional; Region: glpK; PRK00047 745277013579 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 745277013580 N- and C-terminal domain interface [polypeptide binding]; other site 745277013581 active site 745277013582 MgATP binding site [chemical binding]; other site 745277013583 catalytic site [active] 745277013584 metal binding site [ion binding]; metal-binding site 745277013585 glycerol binding site [chemical binding]; other site 745277013586 homotetramer interface [polypeptide binding]; other site 745277013587 homodimer interface [polypeptide binding]; other site 745277013588 FBP binding site [chemical binding]; other site 745277013589 protein IIAGlc interface [polypeptide binding]; other site 745277013590 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 745277013591 putative active site [active] 745277013592 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 745277013593 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277013594 putative substrate translocation pore; other site 745277013595 ferredoxin-NADP reductase; Provisional; Region: PRK10926 745277013596 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 745277013597 FAD binding pocket [chemical binding]; other site 745277013598 FAD binding motif [chemical binding]; other site 745277013599 phosphate binding motif [ion binding]; other site 745277013600 beta-alpha-beta structure motif; other site 745277013601 NAD binding pocket [chemical binding]; other site 745277013602 Predicted membrane protein [Function unknown]; Region: COG3152 745277013603 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 745277013604 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 745277013605 substrate binding site [chemical binding]; other site 745277013606 dimer interface [polypeptide binding]; other site 745277013607 catalytic triad [active] 745277013608 sulfate transporter subunit; Provisional; Region: PRK10752 745277013609 6-phosphofructokinase; Provisional; Region: PRK03202 745277013610 active site 745277013611 ADP/pyrophosphate binding site [chemical binding]; other site 745277013612 dimerization interface [polypeptide binding]; other site 745277013613 allosteric effector site; other site 745277013614 fructose-1,6-bisphosphate binding site; other site 745277013615 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 745277013616 dimer interface [polypeptide binding]; other site 745277013617 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 745277013618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277013619 active site 745277013620 phosphorylation site [posttranslational modification] 745277013621 intermolecular recognition site; other site 745277013622 dimerization interface [polypeptide binding]; other site 745277013623 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 745277013624 DNA binding site [nucleotide binding] 745277013625 two-component sensor protein; Provisional; Region: cpxA; PRK09470 745277013626 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 745277013627 dimerization interface [polypeptide binding]; other site 745277013628 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745277013629 dimer interface [polypeptide binding]; other site 745277013630 phosphorylation site [posttranslational modification] 745277013631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277013632 ATP binding site [chemical binding]; other site 745277013633 Mg2+ binding site [ion binding]; other site 745277013634 G-X-G motif; other site 745277013635 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 745277013636 serine acetyltransferase; Provisional; Region: cysE; PRK11132 745277013637 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 745277013638 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 745277013639 trimer interface [polypeptide binding]; other site 745277013640 active site 745277013641 substrate binding site [chemical binding]; other site 745277013642 CoA binding site [chemical binding]; other site 745277013643 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 745277013644 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 745277013645 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 745277013646 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 745277013647 SecA binding site; other site 745277013648 Preprotein binding site; other site 745277013649 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 745277013650 GSH binding site [chemical binding]; other site 745277013651 catalytic residues [active] 745277013652 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 745277013653 active site residue [active] 745277013654 phosphoglyceromutase; Provisional; Region: PRK05434 745277013655 AmiB activator; Provisional; Region: PRK11637 745277013656 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 745277013657 Peptidase family M23; Region: Peptidase_M23; pfam01551 745277013658 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 745277013659 NodB motif; other site 745277013660 putative active site [active] 745277013661 putative catalytic site [active] 745277013662 Zn binding site [ion binding]; other site 745277013663 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 745277013664 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 745277013665 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 745277013666 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 745277013667 NAD(P) binding site [chemical binding]; other site 745277013668 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 745277013669 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 745277013670 substrate-cofactor binding pocket; other site 745277013671 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277013672 catalytic residue [active] 745277013673 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 745277013674 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 745277013675 NADP binding site [chemical binding]; other site 745277013676 homopentamer interface [polypeptide binding]; other site 745277013677 substrate binding site [chemical binding]; other site 745277013678 active site 745277013679 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 745277013680 putative active site [active] 745277013681 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 745277013682 putative active site [active] 745277013683 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 745277013684 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 745277013685 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 745277013686 Ligand binding site; other site 745277013687 metal-binding site 745277013688 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 745277013689 O-Antigen ligase; Region: Wzy_C; pfam04932 745277013690 putative glycosyl transferase; Provisional; Region: PRK10073 745277013691 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 745277013692 active site 745277013693 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 745277013694 putative active site [active] 745277013695 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 745277013696 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 745277013697 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 745277013698 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 745277013699 Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138 745277013700 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 745277013701 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 745277013702 putative metal binding site; other site 745277013703 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 745277013704 active site 745277013705 (T/H)XGH motif; other site 745277013706 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 745277013707 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 745277013708 DNA binding site [nucleotide binding] 745277013709 catalytic residue [active] 745277013710 H2TH interface [polypeptide binding]; other site 745277013711 putative catalytic residues [active] 745277013712 turnover-facilitating residue; other site 745277013713 intercalation triad [nucleotide binding]; other site 745277013714 8OG recognition residue [nucleotide binding]; other site 745277013715 putative reading head residues; other site 745277013716 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 745277013717 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 745277013718 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 745277013719 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 745277013720 hypothetical protein; Reviewed; Region: PRK00024 745277013721 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 745277013722 MPN+ (JAMM) motif; other site 745277013723 Zinc-binding site [ion binding]; other site 745277013724 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 745277013725 Flavoprotein; Region: Flavoprotein; cl19190 745277013726 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 745277013727 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 745277013728 trimer interface [polypeptide binding]; other site 745277013729 active site 745277013730 division inhibitor protein; Provisional; Region: slmA; PRK09480 745277013731 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745277013732 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 745277013733 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 745277013734 Predicted membrane protein [Function unknown]; Region: COG4984 745277013735 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 745277013736 active site 745277013737 ribonuclease PH; Reviewed; Region: rph; PRK00173 745277013738 Ribonuclease PH; Region: RNase_PH_bact; cd11362 745277013739 hexamer interface [polypeptide binding]; other site 745277013740 active site 745277013741 hypothetical protein; Provisional; Region: PRK11820 745277013742 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 745277013743 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 745277013744 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 745277013745 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 745277013746 dimer interface [polypeptide binding]; other site 745277013747 active site 745277013748 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 745277013749 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745277013750 Predicted membrane protein [Function unknown]; Region: COG2860 745277013751 UPF0126 domain; Region: UPF0126; pfam03458 745277013752 UPF0126 domain; Region: UPF0126; pfam03458 745277013753 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 745277013754 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 745277013755 nucleotide binding pocket [chemical binding]; other site 745277013756 K-X-D-G motif; other site 745277013757 catalytic site [active] 745277013758 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 745277013759 Guanylate kinase; Region: Guanylate_kin; pfam00625 745277013760 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 745277013761 catalytic site [active] 745277013762 G-X2-G-X-G-K; other site 745277013763 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 745277013764 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 745277013765 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 745277013766 Zn2+ binding site [ion binding]; other site 745277013767 Mg2+ binding site [ion binding]; other site 745277013768 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 745277013769 synthetase active site [active] 745277013770 NTP binding site [chemical binding]; other site 745277013771 metal binding site [ion binding]; metal-binding site 745277013772 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 745277013773 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 745277013774 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 745277013775 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 745277013776 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 745277013777 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 745277013778 Y-family of DNA polymerases; Region: PolY; cl12025 745277013779 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 745277013780 generic binding surface II; other site 745277013781 ssDNA binding site; other site 745277013782 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 745277013783 ATP binding site [chemical binding]; other site 745277013784 putative Mg++ binding site [ion binding]; other site 745277013785 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 745277013786 nucleotide binding region [chemical binding]; other site 745277013787 ATP-binding site [chemical binding]; other site 745277013788 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 745277013789 Sodium/glutamate symporter; Region: Glt_symporter; cl19414 745277013790 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 745277013791 Sulfate transporter family; Region: Sulfate_transp; cl19250 745277013792 AsmA family; Region: AsmA; pfam05170 745277013793 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 745277013794 Coenzyme A binding pocket [chemical binding]; other site 745277013795 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 745277013796 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 745277013797 putative active site [active] 745277013798 dimerization interface [polypeptide binding]; other site 745277013799 putative tRNAtyr binding site [nucleotide binding]; other site 745277013800 hypothetical protein; Reviewed; Region: PRK01637 745277013801 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 745277013802 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 745277013803 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745277013804 motif II; other site 745277013805 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 745277013806 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 745277013807 G1 box; other site 745277013808 putative GEF interaction site [polypeptide binding]; other site 745277013809 GTP/Mg2+ binding site [chemical binding]; other site 745277013810 Switch I region; other site 745277013811 G2 box; other site 745277013812 G3 box; other site 745277013813 Switch II region; other site 745277013814 G4 box; other site 745277013815 G5 box; other site 745277013816 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 745277013817 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 745277013818 glutamine synthetase; Provisional; Region: glnA; PRK09469 745277013819 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 745277013820 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 745277013821 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 745277013822 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 745277013823 putative active site [active] 745277013824 heme pocket [chemical binding]; other site 745277013825 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745277013826 dimer interface [polypeptide binding]; other site 745277013827 phosphorylation site [posttranslational modification] 745277013828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277013829 ATP binding site [chemical binding]; other site 745277013830 Mg2+ binding site [ion binding]; other site 745277013831 G-X-G motif; other site 745277013832 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 745277013833 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277013834 active site 745277013835 phosphorylation site [posttranslational modification] 745277013836 intermolecular recognition site; other site 745277013837 dimerization interface [polypeptide binding]; other site 745277013838 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745277013839 Walker A motif; other site 745277013840 ATP binding site [chemical binding]; other site 745277013841 Walker B motif; other site 745277013842 arginine finger; other site 745277013843 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 745277013844 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 745277013845 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 745277013846 FeS/SAM binding site; other site 745277013847 HemN C-terminal domain; Region: HemN_C; pfam06969 745277013848 Der GTPase activator; Provisional; Region: PRK05244 745277013849 Predicted GTPase [General function prediction only]; Region: COG0218 745277013850 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 745277013851 G1 box; other site 745277013852 GTP/Mg2+ binding site [chemical binding]; other site 745277013853 Switch I region; other site 745277013854 G2 box; other site 745277013855 G3 box; other site 745277013856 Switch II region; other site 745277013857 G4 box; other site 745277013858 G5 box; other site 745277013859 DNA polymerase I; Provisional; Region: PRK05755 745277013860 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 745277013861 active site 745277013862 metal binding site 1 [ion binding]; metal-binding site 745277013863 putative 5' ssDNA interaction site; other site 745277013864 metal binding site 3; metal-binding site 745277013865 metal binding site 2 [ion binding]; metal-binding site 745277013866 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 745277013867 putative DNA binding site [nucleotide binding]; other site 745277013868 putative metal binding site [ion binding]; other site 745277013869 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 745277013870 active site 745277013871 catalytic site [active] 745277013872 substrate binding site [chemical binding]; other site 745277013873 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 745277013874 active site 745277013875 DNA binding site [nucleotide binding] 745277013876 catalytic site [active] 745277013877 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 745277013878 catalytic residues [active] 745277013879 hinge region; other site 745277013880 alpha helical domain; other site 745277013881 serine/threonine protein kinase; Provisional; Region: PRK11768 745277013882 Phosphotransferase enzyme family; Region: APH; pfam01636 745277013883 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 745277013884 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 745277013885 GTP binding site; other site 745277013886 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 745277013887 Walker A motif; other site 745277013888 Transcriptional regulators [Transcription]; Region: FadR; COG2186 745277013889 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745277013890 DNA-binding site [nucleotide binding]; DNA binding site 745277013891 FCD domain; Region: FCD; pfam07729 745277013892 transcriptional repressor RbsR; Provisional; Region: PRK10423 745277013893 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745277013894 DNA binding site [nucleotide binding] 745277013895 domain linker motif; other site 745277013896 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 745277013897 dimerization interface [polypeptide binding]; other site 745277013898 ligand binding site [chemical binding]; other site 745277013899 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 745277013900 substrate binding site [chemical binding]; other site 745277013901 dimer interface [polypeptide binding]; other site 745277013902 ATP binding site [chemical binding]; other site 745277013903 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 745277013904 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 745277013905 ligand binding site [chemical binding]; other site 745277013906 dimerization interface [polypeptide binding]; other site 745277013907 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 745277013908 TM-ABC transporter signature motif; other site 745277013909 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 745277013910 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 745277013911 Walker A/P-loop; other site 745277013912 ATP binding site [chemical binding]; other site 745277013913 Q-loop/lid; other site 745277013914 ABC transporter signature motif; other site 745277013915 Walker B; other site 745277013916 D-loop; other site 745277013917 H-loop/switch region; other site 745277013918 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 745277013919 D-ribose pyranase; Provisional; Region: PRK11797 745277013920 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 745277013921 regulatory ATPase RavA; Provisional; Region: PRK13531 745277013922 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745277013923 Walker A motif; other site 745277013924 ATP binding site [chemical binding]; other site 745277013925 Walker B motif; other site 745277013926 arginine finger; other site 745277013927 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 745277013928 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425 745277013929 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 745277013930 metal ion-dependent adhesion site (MIDAS); other site 745277013931 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 745277013932 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 745277013933 putative DNA binding site [nucleotide binding]; other site 745277013934 putative Zn2+ binding site [ion binding]; other site 745277013935 AsnC family; Region: AsnC_trans_reg; pfam01037 745277013936 FMN-binding protein MioC; Provisional; Region: PRK09004 745277013937 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 745277013938 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 745277013939 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 745277013940 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277013941 S-adenosylmethionine binding site [chemical binding]; other site 745277013942 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 745277013943 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 745277013944 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 745277013945 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 745277013946 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 745277013947 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 745277013948 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 745277013949 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 745277013950 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 745277013951 beta subunit interaction interface [polypeptide binding]; other site 745277013952 Walker A motif; other site 745277013953 ATP binding site [chemical binding]; other site 745277013954 Walker B motif; other site 745277013955 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 745277013956 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 745277013957 core domain interface [polypeptide binding]; other site 745277013958 delta subunit interface [polypeptide binding]; other site 745277013959 epsilon subunit interface [polypeptide binding]; other site 745277013960 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 745277013961 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 745277013962 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 745277013963 alpha subunit interaction interface [polypeptide binding]; other site 745277013964 Walker A motif; other site 745277013965 ATP binding site [chemical binding]; other site 745277013966 Walker B motif; other site 745277013967 inhibitor binding site; inhibition site 745277013968 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 745277013969 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 745277013970 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 745277013971 gamma subunit interface [polypeptide binding]; other site 745277013972 epsilon subunit interface [polypeptide binding]; other site 745277013973 LBP interface [polypeptide binding]; other site 745277013974 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 745277013975 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 745277013976 Substrate binding site; other site 745277013977 Mg++ binding site; other site 745277013978 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 745277013979 active site 745277013980 substrate binding site [chemical binding]; other site 745277013981 CoA binding site [chemical binding]; other site 745277013982 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 745277013983 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 745277013984 glutaminase active site [active] 745277013985 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 745277013986 dimer interface [polypeptide binding]; other site 745277013987 active site 745277013988 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 745277013989 dimer interface [polypeptide binding]; other site 745277013990 active site 745277013991 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 745277013992 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 745277013993 RNA binding surface [nucleotide binding]; other site 745277013994 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 745277013995 probable active site [active] 745277013996 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 745277013997 substrate binding pocket [chemical binding]; other site 745277013998 membrane-bound complex binding site; other site 745277013999 hinge residues; other site 745277014000 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 745277014001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277014002 dimer interface [polypeptide binding]; other site 745277014003 conserved gate region; other site 745277014004 putative PBP binding loops; other site 745277014005 ABC-ATPase subunit interface; other site 745277014006 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 745277014007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277014008 dimer interface [polypeptide binding]; other site 745277014009 conserved gate region; other site 745277014010 putative PBP binding loops; other site 745277014011 ABC-ATPase subunit interface; other site 745277014012 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 745277014013 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 745277014014 Walker A/P-loop; other site 745277014015 ATP binding site [chemical binding]; other site 745277014016 Q-loop/lid; other site 745277014017 ABC transporter signature motif; other site 745277014018 Walker B; other site 745277014019 D-loop; other site 745277014020 H-loop/switch region; other site 745277014021 transcriptional regulator PhoU; Provisional; Region: PRK11115 745277014022 PhoU domain; Region: PhoU; pfam01895 745277014023 PhoU domain; Region: PhoU; pfam01895 745277014024 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 745277014025 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745277014026 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 745277014027 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 745277014028 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 745277014029 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 745277014030 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 745277014031 Sulfate transporter family; Region: Sulfate_transp; cl19250 745277014032 Predicted flavoprotein [General function prediction only]; Region: COG0431 745277014033 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 745277014034 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 745277014035 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 745277014036 dimerization interface [polypeptide binding]; other site 745277014037 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 745277014038 dimer interface [polypeptide binding]; other site 745277014039 putative CheW interface [polypeptide binding]; other site 745277014040 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277014041 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277014042 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 745277014043 dimerization interface [polypeptide binding]; other site 745277014044 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 745277014045 short chain dehydrogenase; Region: adh_short; pfam00106 745277014046 putative NAD(P) binding site [chemical binding]; other site 745277014047 homodimer interface [polypeptide binding]; other site 745277014048 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 745277014049 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 745277014050 trmE is a tRNA modification GTPase; Region: trmE; cd04164 745277014051 G1 box; other site 745277014052 GTP/Mg2+ binding site [chemical binding]; other site 745277014053 Switch I region; other site 745277014054 G2 box; other site 745277014055 Switch II region; other site 745277014056 G3 box; other site 745277014057 G4 box; other site 745277014058 G5 box; other site 745277014059 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 745277014060 membrane protein insertase; Provisional; Region: PRK01318 745277014061 YidC periplasmic domain; Region: YidC_periplas; pfam14849 745277014062 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 745277014063 hypothetical protein; Validated; Region: PRK00041 745277014064 ribonuclease P; Reviewed; Region: rnpA; PRK01732 745277014065 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 745277014066 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; cl19875 745277014067 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 745277014068 ParA-like protein; Provisional; Region: PHA02518 745277014069 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 745277014070 P-loop; other site 745277014071 Magnesium ion binding site [ion binding]; other site 745277014072 SnoaL-like domain; Region: SnoaL_2; pfam12680 745277014073 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277014074 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277014075 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 745277014076 putative effector binding pocket; other site 745277014077 putative dimerization interface [polypeptide binding]; other site 745277014078 Exonuclease V - a 5' deoxyribonuclease; Region: Exo5; pfam09810 745277014079 Initiator Replication protein; Region: Rep_3; pfam01051 745277014080 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 745277014081 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 745277014082 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 745277014083 Transcriptional regulators [Transcription]; Region: PurR; COG1609 745277014084 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745277014085 DNA binding site [nucleotide binding] 745277014086 domain linker motif; other site 745277014087 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 745277014088 putative dimerization interface [polypeptide binding]; other site 745277014089 putative ligand binding site [chemical binding]; other site 745277014090 galactoside permease; Reviewed; Region: lacY; PRK09528 745277014091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277014092 putative substrate translocation pore; other site 745277014093 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 745277014094 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 745277014095 substrate binding [chemical binding]; other site 745277014096 active site 745277014097 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 745277014098 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 745277014099 maltose O-acetyltransferase; Provisional; Region: PRK10092 745277014100 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 745277014101 active site 745277014102 substrate binding site [chemical binding]; other site 745277014103 trimer interface [polypeptide binding]; other site 745277014104 CoA binding site [chemical binding]; other site 745277014105 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 745277014106 MltA-interacting protein MipA; Region: MipA; cl01504 745277014107 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 745277014108 HlyD family secretion protein; Region: HlyD_3; pfam13437 745277014109 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 745277014110 MMPL family; Region: MMPL; cl14618 745277014111 General stress protein [General function prediction only]; Region: GsiB; COG3729 745277014112 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 745277014113 dimerization interface [polypeptide binding]; other site 745277014114 metal binding site [ion binding]; metal-binding site 745277014115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 745277014116 Competence-damaged protein; Region: CinA; pfam02464 745277014117 trehalose synthase; Region: treS_nterm; TIGR02456 745277014118 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 745277014119 active site 745277014120 catalytic site [active] 745277014121 short chain dehydrogenase; Provisional; Region: PRK07109 745277014122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745277014123 NAD(P) binding site [chemical binding]; other site 745277014124 active site 745277014125 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 745277014126 dimanganese center [ion binding]; other site 745277014127 Fic/DOC family; Region: Fic; cl00960 745277014128 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 745277014129 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 745277014130 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 745277014131 Helix-turn-helix domain; Region: HTH_18; pfam12833 745277014132 ornithine cyclodeaminase; Validated; Region: PRK06199 745277014133 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 745277014134 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 745277014135 homotrimer interaction site [polypeptide binding]; other site 745277014136 putative active site [active] 745277014137 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 745277014138 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 745277014139 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 745277014140 active site 745277014141 Ogr/Delta-like zinc finger; Region: Ogr_Delta; cl19592 745277014142 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277014143 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277014144 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 745277014145 putative effector binding pocket; other site 745277014146 dimerization interface [polypeptide binding]; other site 745277014147 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 745277014148 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 745277014149 NAD(P) binding site [chemical binding]; other site 745277014150 active site 745277014151 Epoxide hydrolase N terminus; Region: EHN; pfam06441 745277014152 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 745277014153 Cache domain; Region: Cache_1; pfam02743 745277014154 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745277014155 metal binding site [ion binding]; metal-binding site 745277014156 active site 745277014157 I-site; other site 745277014158 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 745277014159 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 745277014160 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 745277014161 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 745277014162 Transposase; Region: HTH_Tnp_1; cl17663 745277014163 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 745277014164 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 745277014165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277014166 putative substrate translocation pore; other site 745277014167 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 745277014168 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 745277014169 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 745277014170 HlyD family secretion protein; Region: HlyD_3; pfam13437 745277014171 MarR family; Region: MarR_2; cl17246 745277014172 Transcriptional regulators [Transcription]; Region: MarR; COG1846 745277014173 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 745277014174 active site 745277014175 DNA binding site [nucleotide binding] 745277014176 Int/Topo IB signature motif; other site 745277014177 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 745277014178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 745277014179 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 745277014180 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745277014181 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 745277014182 Putative lysophospholipase; Region: Hydrolase_4; cl19140 745277014183 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 745277014184 Probable pheophorbidase; Region: PLN02965; cl17657 745277014185 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 745277014186 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 745277014187 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 745277014188 potential catalytic triad [active] 745277014189 conserved cys residue [active] 745277014190 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 745277014191 NAD(P) binding site [chemical binding]; other site 745277014192 catalytic residues [active] 745277014193 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745277014194 salt bridge; other site 745277014195 non-specific DNA binding site [nucleotide binding]; other site 745277014196 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 745277014197 sequence-specific DNA binding site [nucleotide binding]; other site 745277014198 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277014199 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277014200 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 745277014201 putative effector binding pocket; other site 745277014202 dimerization interface [polypeptide binding]; other site 745277014203 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 745277014204 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 745277014205 putative C-terminal domain interface [polypeptide binding]; other site 745277014206 putative GSH binding site (G-site) [chemical binding]; other site 745277014207 putative dimer interface [polypeptide binding]; other site 745277014208 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 745277014209 N-terminal domain interface [polypeptide binding]; other site 745277014210 dimer interface [polypeptide binding]; other site 745277014211 substrate binding pocket (H-site) [chemical binding]; other site 745277014212 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 745277014213 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 745277014214 multiple promoter invertase; Provisional; Region: mpi; PRK13413 745277014215 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 745277014216 catalytic residues [active] 745277014217 catalytic nucleophile [active] 745277014218 Presynaptic Site I dimer interface [polypeptide binding]; other site 745277014219 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 745277014220 Synaptic Flat tetramer interface [polypeptide binding]; other site 745277014221 Synaptic Site I dimer interface [polypeptide binding]; other site 745277014222 DNA binding site [nucleotide binding] 745277014223 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569 745277014224 DNA-binding interface [nucleotide binding]; DNA binding site 745277014225 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 745277014226 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745277014227 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 745277014228 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 745277014229 substrate binding site [chemical binding]; other site 745277014230 oxyanion hole (OAH) forming residues; other site 745277014231 trimer interface [polypeptide binding]; other site 745277014232 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 745277014233 dimerization interface [polypeptide binding]; other site 745277014234 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 745277014235 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 745277014236 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 745277014237 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 745277014238 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 745277014239 [4Fe-4S] binding site [ion binding]; other site 745277014240 molybdopterin cofactor binding site; other site 745277014241 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 745277014242 molybdopterin cofactor binding site; other site 745277014243 Uncharacterized conserved protein [Function unknown]; Region: COG2427 745277014244 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 745277014245 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 745277014246 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 745277014247 General stress protein [General function prediction only]; Region: GsiB; COG3729 745277014248 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 745277014249 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 745277014250 putative symporter YagG; Provisional; Region: PRK09669; cl15392 745277014251 Transcriptional regulators [Transcription]; Region: PurR; COG1609 745277014252 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745277014253 DNA binding site [nucleotide binding] 745277014254 domain linker motif; other site 745277014255 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 745277014256 dimerization interface [polypeptide binding]; other site 745277014257 ligand binding site [chemical binding]; other site 745277014258 Predicted transcriptional regulators [Transcription]; Region: COG1733 745277014259 putative DNA binding site [nucleotide binding]; other site 745277014260 putative Zn2+ binding site [ion binding]; other site 745277014261 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 745277014262 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 745277014263 NAD(P) binding site [chemical binding]; other site 745277014264 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 745277014265 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745277014266 DNA-binding site [nucleotide binding]; DNA binding site 745277014267 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 745277014268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277014269 homodimer interface [polypeptide binding]; other site 745277014270 catalytic residue [active] 745277014271 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 745277014272 Uncharacterized conserved protein [Function unknown]; Region: COG2128 745277014273 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277014274 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277014275 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 745277014276 putative substrate binding pocket [chemical binding]; other site 745277014277 putative dimerization interface [polypeptide binding]; other site 745277014278 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 745277014279 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 745277014280 Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase [General function prediction only]; Region: COG3576 745277014281 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 745277014282 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 745277014283 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 745277014284 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 745277014285 dimer interface [polypeptide binding]; other site 745277014286 PYR/PP interface [polypeptide binding]; other site 745277014287 TPP binding site [chemical binding]; other site 745277014288 substrate binding site [chemical binding]; other site 745277014289 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 745277014290 Domain of unknown function; Region: EKR; pfam10371 745277014291 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 745277014292 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 745277014293 TPP-binding site [chemical binding]; other site 745277014294 dimer interface [polypeptide binding]; other site 745277014295 flavodoxin FldA; Validated; Region: PRK09267 745277014296 NifQ; Region: NifQ; pfam04891 745277014297 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 745277014298 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 745277014299 FeS/SAM binding site; other site 745277014300 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 745277014301 Nif-specific regulatory protein; Region: nifA; TIGR01817 745277014302 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 745277014303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745277014304 Walker A motif; other site 745277014305 ATP binding site [chemical binding]; other site 745277014306 Walker B motif; other site 745277014307 arginine finger; other site 745277014308 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 745277014309 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 745277014310 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 745277014311 putative active site [active] 745277014312 heme pocket [chemical binding]; other site 745277014313 Protein of unknown function (DUF3209); Region: DUF3209; pfam11483 745277014314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277014315 ATP binding site [chemical binding]; other site 745277014316 Mg2+ binding site [ion binding]; other site 745277014317 G-X-G motif; other site 745277014318 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 745277014319 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 745277014320 NifZ domain; Region: NifZ; pfam04319 745277014321 Nitrogen fixation protein NifW; Region: NifW; cl03935 745277014322 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 745277014323 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 745277014324 active site 745277014325 catalytic residues [active] 745277014326 metal binding site [ion binding]; metal-binding site 745277014327 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 745277014328 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 745277014329 catalytic residue [active] 745277014330 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 745277014331 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 745277014332 trimerization site [polypeptide binding]; other site 745277014333 active site 745277014334 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 745277014335 NifU-like domain; Region: NifU; pfam01106 745277014336 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 745277014337 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 745277014338 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 745277014339 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 745277014340 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 745277014341 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 745277014342 NifT/FixU protein; Region: NifT; pfam06988 745277014343 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 745277014344 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 745277014345 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 745277014346 MoFe protein beta/alpha subunit interactions; other site 745277014347 Beta subunit P cluster binding residues; other site 745277014348 MoFe protein beta subunit/Fe protein contacts; other site 745277014349 MoFe protein dimer/ dimer interactions; other site 745277014350 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 745277014351 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 745277014352 MoFe protein alpha/beta subunit interactions; other site 745277014353 Alpha subunit P cluster binding residues; other site 745277014354 FeMoco binding residues [chemical binding]; other site 745277014355 MoFe protein alpha subunit/Fe protein contacts; other site 745277014356 MoFe protein dimer/ dimer interactions; other site 745277014357 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 745277014358 nitrogenase iron protein; Region: nifH; TIGR01287 745277014359 Nucleotide-binding sites [chemical binding]; other site 745277014360 Walker A motif; other site 745277014361 Switch I region of nucleotide binding site; other site 745277014362 Fe4S4 binding sites [ion binding]; other site 745277014363 Switch II region of nucleotide binding site; other site 745277014364 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 745277014365 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745277014366 Walker A motif; other site 745277014367 ATP binding site [chemical binding]; other site 745277014368 Walker B motif; other site 745277014369 arginine finger; other site 745277014370 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745277014371 Walker A motif; other site 745277014372 ATP binding site [chemical binding]; other site 745277014373 Walker B motif; other site 745277014374 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 745277014375 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 745277014376 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 745277014377 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 745277014378 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 745277014379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 745277014380 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 745277014381 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 745277014382 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 745277014383 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 745277014384 PAAR motif; Region: PAAR_motif; pfam05488 745277014385 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 745277014386 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 745277014387 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 745277014388 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 745277014389 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 745277014390 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 745277014391 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 745277014392 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 745277014393 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 745277014394 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 745277014395 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 745277014396 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 745277014397 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 745277014398 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 745277014399 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 745277014400 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 745277014401 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 745277014402 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 745277014403 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 745277014404 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 745277014405 ImpA domain protein; Region: DUF3702; pfam12486 745277014406 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 745277014407 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 745277014408 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 745277014409 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 745277014410 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 745277014411 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 745277014412 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 745277014413 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 745277014414 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277014415 Walker A/P-loop; other site 745277014416 ATP binding site [chemical binding]; other site 745277014417 Q-loop/lid; other site 745277014418 ABC transporter signature motif; other site 745277014419 Walker B; other site 745277014420 D-loop; other site 745277014421 H-loop/switch region; other site 745277014422 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 745277014423 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 745277014424 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277014425 Walker A/P-loop; other site 745277014426 ATP binding site [chemical binding]; other site 745277014427 Q-loop/lid; other site 745277014428 ABC transporter signature motif; other site 745277014429 Walker B; other site 745277014430 D-loop; other site 745277014431 H-loop/switch region; other site 745277014432 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745277014433 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 745277014434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277014435 dimer interface [polypeptide binding]; other site 745277014436 conserved gate region; other site 745277014437 putative PBP binding loops; other site 745277014438 ABC-ATPase subunit interface; other site 745277014439 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 745277014440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277014441 dimer interface [polypeptide binding]; other site 745277014442 conserved gate region; other site 745277014443 putative PBP binding loops; other site 745277014444 ABC-ATPase subunit interface; other site 745277014445 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 745277014446 Autoinducer binding domain; Region: Autoind_bind; pfam03472 745277014447 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 745277014448 DNA binding residues [nucleotide binding] 745277014449 dimerization interface [polypeptide binding]; other site 745277014450 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 745277014451 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 745277014452 Cupin; Region: Cupin_6; pfam12852 745277014453 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277014454 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 745277014455 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277014456 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 745277014457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277014458 putative substrate translocation pore; other site 745277014459 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 745277014460 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 745277014461 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 745277014462 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 745277014463 Transcriptional regulators [Transcription]; Region: FadR; COG2186 745277014464 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745277014465 DNA-binding site [nucleotide binding]; DNA binding site 745277014466 FCD domain; Region: FCD; pfam07729 745277014467 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 745277014468 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 745277014469 NAD binding site [chemical binding]; other site 745277014470 homotetramer interface [polypeptide binding]; other site 745277014471 homodimer interface [polypeptide binding]; other site 745277014472 active site 745277014473 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 745277014474 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 745277014475 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 745277014476 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 745277014477 putative active site pocket [active] 745277014478 metal binding site [ion binding]; metal-binding site 745277014479 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 745277014480 Amidohydrolase; Region: Amidohydro_2; pfam04909 745277014481 short chain dehydrogenase; Provisional; Region: PRK08628 745277014482 classical (c) SDRs; Region: SDR_c; cd05233 745277014483 NAD(P) binding site [chemical binding]; other site 745277014484 active site 745277014485 Domain of unknown function (DUF718); Region: DUF718; pfam05336 745277014486 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 745277014487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277014488 putative substrate translocation pore; other site 745277014489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277014490 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 745277014491 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 745277014492 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Provisional; Region: PRK08575 745277014493 substrate binding site [chemical binding]; other site 745277014494 THF binding site; other site 745277014495 zinc-binding site [ion binding]; other site 745277014496 methionine sulfoxide reductase A; Provisional; Region: PRK13014 745277014497 methionine sulfoxide reductase B; Provisional; Region: PRK00222 745277014498 SelR domain; Region: SelR; pfam01641 745277014499 alpha-glucosidase; Provisional; Region: PRK10426 745277014500 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 745277014501 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 745277014502 putative active site [active] 745277014503 putative catalytic site [active] 745277014504 putative symporter YagG; Provisional; Region: PRK09669 745277014505 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 745277014506 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 745277014507 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 745277014508 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 745277014509 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 745277014510 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 745277014511 active site 745277014512 metal binding site [ion binding]; metal-binding site 745277014513 nudix motif; other site 745277014514 topology modulation protein; Reviewed; Region: PRK08118 745277014515 AAA domain; Region: AAA_17; pfam13207 745277014516 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 745277014517 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 745277014518 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 745277014519 NADP binding site [chemical binding]; other site 745277014520 Predicted transcriptional regulators [Transcription]; Region: COG1733 745277014521 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 745277014522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 745277014523 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 745277014524 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 745277014525 active site 745277014526 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 745277014527 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277014528 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 745277014529 dimerization interface [polypeptide binding]; other site 745277014530 substrate binding pocket [chemical binding]; other site 745277014531 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 745277014532 EamA-like transporter family; Region: EamA; cl17759 745277014533 EamA-like transporter family; Region: EamA; pfam00892 745277014534 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 745277014535 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 745277014536 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 745277014537 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 745277014538 putative active site [active] 745277014539 YdjC motif; other site 745277014540 Mg binding site [ion binding]; other site 745277014541 putative homodimer interface [polypeptide binding]; other site 745277014542 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 745277014543 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 745277014544 NAD binding site [chemical binding]; other site 745277014545 sugar binding site [chemical binding]; other site 745277014546 divalent metal binding site [ion binding]; other site 745277014547 tetramer (dimer of dimers) interface [polypeptide binding]; other site 745277014548 dimer interface [polypeptide binding]; other site 745277014549 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 745277014550 Cupin domain; Region: Cupin_2; pfam07883 745277014551 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277014552 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 745277014553 methionine cluster; other site 745277014554 active site 745277014555 phosphorylation site [posttranslational modification] 745277014556 metal binding site [ion binding]; metal-binding site 745277014557 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 745277014558 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 745277014559 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 745277014560 active site 745277014561 P-loop; other site 745277014562 phosphorylation site [posttranslational modification] 745277014563 Transcriptional regulators [Transcription]; Region: PurR; COG1609 745277014564 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745277014565 DNA binding site [nucleotide binding] 745277014566 domain linker motif; other site 745277014567 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 745277014568 putative dimerization interface [polypeptide binding]; other site 745277014569 putative ligand binding site [chemical binding]; other site 745277014570 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 745277014571 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 745277014572 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 745277014573 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 745277014574 Cytochrome c; Region: Cytochrom_C; cl11414 745277014575 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 745277014576 Cytochrome c; Region: Cytochrom_C; pfam00034 745277014577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 745277014578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277014579 putative substrate translocation pore; other site 745277014580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277014581 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277014582 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277014583 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 745277014584 putative effector binding pocket; other site 745277014585 dimerization interface [polypeptide binding]; other site 745277014586 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 745277014587 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 745277014588 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 745277014589 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 745277014590 Sensors of blue-light using FAD; Region: BLUF; smart01034 745277014591 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 745277014592 tellurite resistance protein TehB; Provisional; Region: PRK11207 745277014593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277014594 S-adenosylmethionine binding site [chemical binding]; other site 745277014595 CsbD-like; Region: CsbD; pfam05532 745277014596 putative phosphoketolase; Provisional; Region: PRK05261 745277014597 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 745277014598 TPP-binding site; other site 745277014599 XFP C-terminal domain; Region: XFP_C; pfam09363 745277014600 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 745277014601 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 745277014602 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 745277014603 Transposase IS200 like; Region: Y1_Tnp; pfam01797 745277014604 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 745277014605 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 745277014606 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 745277014607 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 745277014608 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 745277014609 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277014610 Walker A/P-loop; other site 745277014611 ATP binding site [chemical binding]; other site 745277014612 Q-loop/lid; other site 745277014613 ABC transporter signature motif; other site 745277014614 Walker B; other site 745277014615 D-loop; other site 745277014616 H-loop/switch region; other site 745277014617 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 745277014618 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277014619 Walker A/P-loop; other site 745277014620 ATP binding site [chemical binding]; other site 745277014621 Q-loop/lid; other site 745277014622 ABC transporter signature motif; other site 745277014623 Walker B; other site 745277014624 D-loop; other site 745277014625 H-loop/switch region; other site 745277014626 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 745277014627 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 745277014628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277014629 dimer interface [polypeptide binding]; other site 745277014630 conserved gate region; other site 745277014631 putative PBP binding loops; other site 745277014632 ABC-ATPase subunit interface; other site 745277014633 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 745277014634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277014635 dimer interface [polypeptide binding]; other site 745277014636 conserved gate region; other site 745277014637 putative PBP binding loops; other site 745277014638 ABC-ATPase subunit interface; other site 745277014639 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 745277014640 active site 745277014641 tetramer interface [polypeptide binding]; other site 745277014642 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 745277014643 active site 745277014644 tetramer interface [polypeptide binding]; other site 745277014645 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 745277014646 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 745277014647 inhibitor site; inhibition site 745277014648 active site 745277014649 dimer interface [polypeptide binding]; other site 745277014650 catalytic residue [active] 745277014651 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 745277014652 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 745277014653 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 745277014654 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277014655 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 745277014656 dimerization interface [polypeptide binding]; other site 745277014657 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 745277014658 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 745277014659 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 745277014660 Trp docking motif [polypeptide binding]; other site 745277014661 putative active site [active] 745277014662 HipA N-terminal domain; Region: couple_hipA; TIGR03071 745277014663 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 745277014664 HipA-like N-terminal domain; Region: HipA_N; pfam07805 745277014665 HipA-like C-terminal domain; Region: HipA_C; pfam07804 745277014666 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 745277014667 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745277014668 non-specific DNA binding site [nucleotide binding]; other site 745277014669 salt bridge; other site 745277014670 sequence-specific DNA binding site [nucleotide binding]; other site 745277014671 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 745277014672 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745277014673 DNA-binding site [nucleotide binding]; DNA binding site 745277014674 UTRA domain; Region: UTRA; pfam07702 745277014675 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 745277014676 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 745277014677 metal binding site [ion binding]; metal-binding site 745277014678 substrate binding pocket [chemical binding]; other site 745277014679 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 745277014680 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 745277014681 active site turn [active] 745277014682 phosphorylation site [posttranslational modification] 745277014683 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 745277014684 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 745277014685 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 745277014686 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277014687 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277014688 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 745277014689 dimerization interface [polypeptide binding]; other site 745277014690 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 745277014691 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277014692 Walker A/P-loop; other site 745277014693 ATP binding site [chemical binding]; other site 745277014694 Q-loop/lid; other site 745277014695 ABC transporter signature motif; other site 745277014696 Walker B; other site 745277014697 D-loop; other site 745277014698 H-loop/switch region; other site 745277014699 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 745277014700 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 745277014701 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277014702 Walker A/P-loop; other site 745277014703 ATP binding site [chemical binding]; other site 745277014704 Q-loop/lid; other site 745277014705 ABC transporter signature motif; other site 745277014706 Walker B; other site 745277014707 D-loop; other site 745277014708 H-loop/switch region; other site 745277014709 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 745277014710 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 745277014711 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 745277014712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277014713 dimer interface [polypeptide binding]; other site 745277014714 conserved gate region; other site 745277014715 putative PBP binding loops; other site 745277014716 ABC-ATPase subunit interface; other site 745277014717 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 745277014718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277014719 dimer interface [polypeptide binding]; other site 745277014720 conserved gate region; other site 745277014721 putative PBP binding loops; other site 745277014722 ABC-ATPase subunit interface; other site 745277014723 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 745277014724 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 745277014725 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 745277014726 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 745277014727 SEFIR domain; Region: SEFIR; pfam08357 745277014728 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 745277014729 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 745277014730 Initiator Replication protein; Region: Rep_3; pfam01051 745277014731 ParG; Region: ParG; pfam09274 745277014732 ParA-like protein; Provisional; Region: PHA02518 745277014733 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 745277014734 P-loop; other site 745277014735 Magnesium ion binding site [ion binding]; other site 745277014736 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 745277014737 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 745277014738 Walker A/P-loop; other site 745277014739 ATP binding site [chemical binding]; other site 745277014740 Q-loop/lid; other site 745277014741 ABC transporter signature motif; other site 745277014742 Walker B; other site 745277014743 D-loop; other site 745277014744 H-loop/switch region; other site 745277014745 TOBE domain; Region: TOBE_2; pfam08402 745277014746 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 745277014747 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745277014748 DNA-binding site [nucleotide binding]; DNA binding site 745277014749 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 745277014750 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277014751 homodimer interface [polypeptide binding]; other site 745277014752 catalytic residue [active] 745277014753 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 745277014754 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 745277014755 inhibitor-cofactor binding pocket; inhibition site 745277014756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277014757 catalytic residue [active] 745277014758 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 745277014759 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 745277014760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277014761 dimer interface [polypeptide binding]; other site 745277014762 conserved gate region; other site 745277014763 putative PBP binding loops; other site 745277014764 ABC-ATPase subunit interface; other site 745277014765 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 745277014766 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277014767 dimer interface [polypeptide binding]; other site 745277014768 conserved gate region; other site 745277014769 putative PBP binding loops; other site 745277014770 ABC-ATPase subunit interface; other site 745277014771 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 745277014772 classical (c) SDRs; Region: SDR_c; cd05233 745277014773 NAD(P) binding site [chemical binding]; other site 745277014774 active site 745277014775 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 745277014776 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 745277014777 active site 745277014778 ATP binding site [chemical binding]; other site 745277014779 substrate binding site [chemical binding]; other site 745277014780 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 745277014781 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 745277014782 inhibitor-cofactor binding pocket; inhibition site 745277014783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277014784 catalytic residue [active] 745277014785 Transcriptional regulators [Transcription]; Region: GntR; COG1802 745277014786 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745277014787 DNA-binding site [nucleotide binding]; DNA binding site 745277014788 FCD domain; Region: FCD; pfam07729 745277014789 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 745277014790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277014791 putative substrate translocation pore; other site 745277014792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277014793 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 745277014794 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 745277014795 putative [Fe4-S4] binding site [ion binding]; other site 745277014796 putative molybdopterin cofactor binding site [chemical binding]; other site 745277014797 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 745277014798 putative molybdopterin cofactor binding site; other site 745277014799 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 745277014800 4Fe-4S binding domain; Region: Fer4; pfam00037 745277014801 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 745277014802 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 745277014803 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 745277014804 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 745277014805 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 745277014806 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 745277014807 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 745277014808 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 745277014809 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 745277014810 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 745277014811 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 745277014812 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 745277014813 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 745277014814 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 745277014815 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 745277014816 NAD(P) binding site [chemical binding]; other site 745277014817 catalytic residues [active] 745277014818 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277014819 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277014820 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 745277014821 putative dimerization interface [polypeptide binding]; other site 745277014822 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 745277014823 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 745277014824 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 745277014825 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 745277014826 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 745277014827 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 745277014828 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 745277014829 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 745277014830 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 745277014831 Fic/DOC family; Region: Fic; pfam02661 745277014832 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 745277014833 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 745277014834 TM-ABC transporter signature motif; other site 745277014835 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 745277014836 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 745277014837 TM-ABC transporter signature motif; other site 745277014838 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 745277014839 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 745277014840 Walker A/P-loop; other site 745277014841 ATP binding site [chemical binding]; other site 745277014842 Q-loop/lid; other site 745277014843 ABC transporter signature motif; other site 745277014844 Walker B; other site 745277014845 D-loop; other site 745277014846 H-loop/switch region; other site 745277014847 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 745277014848 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 745277014849 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 745277014850 ligand binding site [chemical binding]; other site 745277014851 transcriptional activator RhaS; Provisional; Region: PRK13503 745277014852 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 745277014853 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277014854 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 745277014855 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 745277014856 NAD binding site [chemical binding]; other site 745277014857 catalytic residues [active] 745277014858 substrate binding site [chemical binding]; other site 745277014859 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 745277014860 Rice tungro bacilliform virus P46 protein; Region: RTBV_P46; pfam06216 745277014861 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 745277014862 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 745277014863 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 745277014864 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 745277014865 N-terminal plug; other site 745277014866 ligand-binding site [chemical binding]; other site 745277014867 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 745277014868 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 745277014869 Trp docking motif [polypeptide binding]; other site 745277014870 putative active site [active] 745277014871 Variant SH3 domain; Region: SH3_2; pfam07653 745277014872 Src Homology 3 domain superfamily; Region: SH3; cd00174 745277014873 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 745277014874 putative trimer interface [polypeptide binding]; other site 745277014875 putative active site [active] 745277014876 putative substrate binding site [chemical binding]; other site 745277014877 putative CoA binding site [chemical binding]; other site 745277014878 Protein of unknown function, DUF596; Region: DUF596; cl10492 745277014879 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 745277014880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 745277014881 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 745277014882 Major Facilitator Superfamily; Region: MFS_1; pfam07690 745277014883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277014884 putative substrate translocation pore; other site 745277014885 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277014886 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277014887 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 745277014888 putative substrate binding pocket [chemical binding]; other site 745277014889 putative dimerization interface [polypeptide binding]; other site 745277014890 exodeoxyribonuclease X; Provisional; Region: PRK07983 745277014891 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 745277014892 active site 745277014893 catalytic site [active] 745277014894 substrate binding site [chemical binding]; other site 745277014895 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 745277014896 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 745277014897 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329 745277014898 putative active site pocket [active] 745277014899 metal binding site [ion binding]; metal-binding site 745277014900 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 745277014901 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 745277014902 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 745277014903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277014904 dimer interface [polypeptide binding]; other site 745277014905 conserved gate region; other site 745277014906 putative PBP binding loops; other site 745277014907 ABC-ATPase subunit interface; other site 745277014908 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 745277014909 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 745277014910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277014911 dimer interface [polypeptide binding]; other site 745277014912 conserved gate region; other site 745277014913 ABC-ATPase subunit interface; other site 745277014914 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 745277014915 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277014916 Walker A/P-loop; other site 745277014917 ATP binding site [chemical binding]; other site 745277014918 Q-loop/lid; other site 745277014919 ABC transporter signature motif; other site 745277014920 Walker B; other site 745277014921 D-loop; other site 745277014922 H-loop/switch region; other site 745277014923 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745277014924 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 745277014925 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277014926 Walker A/P-loop; other site 745277014927 ATP binding site [chemical binding]; other site 745277014928 Q-loop/lid; other site 745277014929 ABC transporter signature motif; other site 745277014930 Walker B; other site 745277014931 D-loop; other site 745277014932 H-loop/switch region; other site 745277014933 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 745277014934 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 745277014935 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 745277014936 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 745277014937 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 745277014938 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 745277014939 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 745277014940 PAAR motif; Region: PAAR_motif; pfam05488 745277014941 Protein of unknown function (DUF3274); Region: DUF3274; pfam11678 745277014942 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 745277014943 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 745277014944 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 745277014945 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 745277014946 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 745277014947 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 745277014948 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 745277014949 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 745277014950 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 745277014951 Major Facilitator Superfamily; Region: MFS_1; pfam07690 745277014952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277014953 putative substrate translocation pore; other site 745277014954 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277014955 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 745277014956 Walker A/P-loop; other site 745277014957 ATP binding site [chemical binding]; other site 745277014958 Q-loop/lid; other site 745277014959 ABC transporter signature motif; other site 745277014960 Walker B; other site 745277014961 D-loop; other site 745277014962 H-loop/switch region; other site 745277014963 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277014964 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 745277014965 Walker A/P-loop; other site 745277014966 ATP binding site [chemical binding]; other site 745277014967 Q-loop/lid; other site 745277014968 ABC transporter signature motif; other site 745277014969 Walker B; other site 745277014970 D-loop; other site 745277014971 H-loop/switch region; other site 745277014972 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745277014973 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 745277014974 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 745277014975 DNA binding site [nucleotide binding] 745277014976 domain linker motif; other site 745277014977 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 745277014978 dimerization interface [polypeptide binding]; other site 745277014979 ligand binding site [chemical binding]; other site 745277014980 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 745277014981 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 745277014982 substrate binding [chemical binding]; other site 745277014983 active site 745277014984 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 745277014985 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 745277014986 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 745277014987 active site turn [active] 745277014988 phosphorylation site [posttranslational modification] 745277014989 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 745277014990 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 745277014991 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 745277014992 trimer interface; other site 745277014993 sugar binding site [chemical binding]; other site 745277014994 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 745277014995 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 745277014996 putative substrate binding site [chemical binding]; other site 745277014997 putative ATP binding site [chemical binding]; other site 745277014998 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 745277014999 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 745277015000 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 745277015001 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 745277015002 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 745277015003 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 745277015004 Surface antigen; Region: Bac_surface_Ag; pfam01103 745277015005 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 745277015006 methionine sulfoxide reductase B; Provisional; Region: PRK05508 745277015007 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 745277015008 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 745277015009 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 745277015010 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 745277015011 N-terminal plug; other site 745277015012 ligand-binding site [chemical binding]; other site 745277015013 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 745277015014 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 745277015015 FAD binding pocket [chemical binding]; other site 745277015016 FAD binding motif [chemical binding]; other site 745277015017 phosphate binding motif [ion binding]; other site 745277015018 NAD binding pocket [chemical binding]; other site 745277015019 Predicted transcriptional regulators [Transcription]; Region: COG1695 745277015020 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 745277015021 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 745277015022 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 745277015023 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 745277015024 active site 745277015025 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 745277015026 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 745277015027 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 745277015028 Moco binding site; other site 745277015029 metal coordination site [ion binding]; other site 745277015030 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 745277015031 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 745277015032 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 745277015033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277015034 active site 745277015035 phosphorylation site [posttranslational modification] 745277015036 intermolecular recognition site; other site 745277015037 dimerization interface [polypeptide binding]; other site 745277015038 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 745277015039 DNA binding site [nucleotide binding] 745277015040 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 745277015041 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 745277015042 dimer interface [polypeptide binding]; other site 745277015043 phosphorylation site [posttranslational modification] 745277015044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277015045 ATP binding site [chemical binding]; other site 745277015046 Mg2+ binding site [ion binding]; other site 745277015047 G-X-G motif; other site 745277015048 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 745277015049 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 745277015050 non-specific DNA binding site [nucleotide binding]; other site 745277015051 salt bridge; other site 745277015052 sequence-specific DNA binding site [nucleotide binding]; other site 745277015053 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 745277015054 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 745277015055 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 745277015056 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 745277015057 DNA binding residues [nucleotide binding] 745277015058 fec operon regulator FecR; Reviewed; Region: PRK09774 745277015059 FecR protein; Region: FecR; pfam04773 745277015060 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 745277015061 Secretin and TonB N terminus short domain; Region: STN; smart00965 745277015062 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 745277015063 N-terminal plug; other site 745277015064 ligand-binding site [chemical binding]; other site 745277015065 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 745277015066 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 745277015067 siderophore binding site; other site 745277015068 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 745277015069 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 745277015070 ABC-ATPase subunit interface; other site 745277015071 dimer interface [polypeptide binding]; other site 745277015072 putative PBP binding regions; other site 745277015073 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 745277015074 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 745277015075 ABC-ATPase subunit interface; other site 745277015076 dimer interface [polypeptide binding]; other site 745277015077 putative PBP binding regions; other site 745277015078 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 745277015079 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 745277015080 Walker A/P-loop; other site 745277015081 ATP binding site [chemical binding]; other site 745277015082 Q-loop/lid; other site 745277015083 ABC transporter signature motif; other site 745277015084 Walker B; other site 745277015085 D-loop; other site 745277015086 H-loop/switch region; other site 745277015087 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 745277015088 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 745277015089 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 745277015090 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 745277015091 active site 745277015092 substrate binding site [chemical binding]; other site 745277015093 FMN binding site [chemical binding]; other site 745277015094 putative catalytic residues [active] 745277015095 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 745277015096 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 745277015097 metal binding site [ion binding]; metal-binding site 745277015098 active site 745277015099 I-site; other site 745277015100 coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110 745277015101 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 745277015102 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 745277015103 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 745277015104 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 745277015105 FeS/SAM binding site; other site 745277015106 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 745277015107 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 745277015108 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 745277015109 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 745277015110 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 745277015111 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 745277015112 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 745277015113 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 745277015114 active site 745277015115 dimer interface [polypeptide binding]; other site 745277015116 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 745277015117 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 745277015118 N-terminal plug; other site 745277015119 ligand-binding site [chemical binding]; other site 745277015120 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 745277015121 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 745277015122 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 745277015123 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 745277015124 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 745277015125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277015126 dimer interface [polypeptide binding]; other site 745277015127 conserved gate region; other site 745277015128 putative PBP binding loops; other site 745277015129 ABC-ATPase subunit interface; other site 745277015130 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 745277015131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 745277015132 dimer interface [polypeptide binding]; other site 745277015133 conserved gate region; other site 745277015134 ABC-ATPase subunit interface; other site 745277015135 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 745277015136 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277015137 Walker A/P-loop; other site 745277015138 ATP binding site [chemical binding]; other site 745277015139 Q-loop/lid; other site 745277015140 ABC transporter signature motif; other site 745277015141 Walker B; other site 745277015142 D-loop; other site 745277015143 H-loop/switch region; other site 745277015144 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 745277015145 Walker A/P-loop; other site 745277015146 ATP binding site [chemical binding]; other site 745277015147 Q-loop/lid; other site 745277015148 ABC transporter signature motif; other site 745277015149 Walker B; other site 745277015150 D-loop; other site 745277015151 H-loop/switch region; other site 745277015152 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 745277015153 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 745277015154 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 745277015155 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 745277015156 dimerization interface [polypeptide binding]; other site 745277015157 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 745277015158 dimer interface [polypeptide binding]; other site 745277015159 putative CheW interface [polypeptide binding]; other site 745277015160 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 745277015161 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 745277015162 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 745277015163 inhibitor-cofactor binding pocket; inhibition site 745277015164 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277015165 catalytic residue [active] 745277015166 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 745277015167 pyridoxal 5'-phosphate binding site [chemical binding]; other site 745277015168 catalytic residue [active] 745277015169 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 745277015170 Mechanosensitive ion channel; Region: MS_channel; pfam00924 745277015171 Predicted membrane protein [Function unknown]; Region: COG2323 745277015172 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 745277015173 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 745277015174 NAD binding site [chemical binding]; other site 745277015175 catalytic Zn binding site [ion binding]; other site 745277015176 structural Zn binding site [ion binding]; other site 745277015177 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 745277015178 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 745277015179 active site 745277015180 catalytic site [active] 745277015181 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 745277015182 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 745277015183 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 745277015184 catalytic site [active] 745277015185 active site 745277015186 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 745277015187 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 745277015188 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 745277015189 intersubunit interface [polypeptide binding]; other site 745277015190 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 745277015191 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 745277015192 GAF domain; Region: GAF; pfam01590 745277015193 Histidine kinase; Region: His_kinase; pfam06580 745277015194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277015195 ATP binding site [chemical binding]; other site 745277015196 Mg2+ binding site [ion binding]; other site 745277015197 G-X-G motif; other site 745277015198 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 745277015199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277015200 active site 745277015201 phosphorylation site [posttranslational modification] 745277015202 intermolecular recognition site; other site 745277015203 dimerization interface [polypeptide binding]; other site 745277015204 LytTr DNA-binding domain; Region: LytTR; smart00850 745277015205 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 745277015206 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 745277015207 P-loop, Walker A motif; other site 745277015208 Base recognition motif; other site 745277015209 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 745277015210 Uncharacterized small protein [Function unknown]; Region: COG2879 745277015211 carbon starvation protein A; Provisional; Region: PRK15015 745277015212 Carbon starvation protein CstA; Region: CstA; pfam02554 745277015213 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 745277015214 Protein of unknown function (DUF796); Region: DUF796; cl01226 745277015215 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 745277015216 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 745277015217 Catalytic site [active] 745277015218 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 745277015219 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 745277015220 active site 745277015221 DNA binding site [nucleotide binding] 745277015222 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 745277015223 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 745277015224 Mechanosensitive ion channel; Region: MS_channel; pfam00924 745277015225 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 745277015226 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 745277015227 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277015228 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 745277015229 substrate binding pocket [chemical binding]; other site 745277015230 dimerization interface [polypeptide binding]; other site 745277015231 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 745277015232 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 745277015233 active site 745277015234 catalytic tetrad [active] 745277015235 Transcriptional regulator [Transcription]; Region: LysR; COG0583 745277015236 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277015237 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 745277015238 putative effector binding pocket; other site 745277015239 putative dimerization interface [polypeptide binding]; other site 745277015240 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 745277015241 Domain of unknown function DUF; Region: DUF204; pfam02659 745277015242 Domain of unknown function DUF; Region: DUF204; pfam02659 745277015243 Protein of unknown function (DUF770); Region: DUF770; pfam05591 745277015244 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 745277015245 Protein of unknown function (DUF877); Region: DUF877; pfam05943 745277015246 Protein of unknown function (DUF796); Region: DUF796; pfam05638 745277015247 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 745277015248 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 745277015249 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 745277015250 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 745277015251 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 745277015252 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 745277015253 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 745277015254 PAAR motif; Region: PAAR_motif; pfam05488 745277015255 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 745277015256 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 745277015257 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 745277015258 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 745277015259 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 745277015260 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 745277015261 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 745277015262 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 745277015263 Clp amino terminal domain; Region: Clp_N; pfam02861 745277015264 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745277015265 Walker A motif; other site 745277015266 ATP binding site [chemical binding]; other site 745277015267 Walker B motif; other site 745277015268 arginine finger; other site 745277015269 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 745277015270 Walker A motif; other site 745277015271 ATP binding site [chemical binding]; other site 745277015272 Walker B motif; other site 745277015273 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 745277015274 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 745277015275 ImpA domain protein; Region: DUF3702; pfam12486 745277015276 Peptidase M35 family; Region: M35_like; cl03449 745277015277 active site 745277015278 Zn binding site [ion binding]; other site 745277015279 K+ potassium transporter; Region: K_trans; cl15781 745277015280 potassium uptake protein; Region: kup; TIGR00794 745277015281 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 745277015282 Beta-lactamase; Region: Beta-lactamase; pfam00144 745277015283 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 745277015284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277015285 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745277015286 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 745277015287 active site 745277015288 motif I; other site 745277015289 motif II; other site 745277015290 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 745277015291 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 745277015292 manganese transport regulator MntR; Provisional; Region: PRK11050 745277015293 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 745277015294 DNA-binding site [nucleotide binding]; DNA binding site 745277015295 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 745277015296 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 745277015297 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 745277015298 metal binding site [ion binding]; metal-binding site 745277015299 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 745277015300 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 745277015301 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 745277015302 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 745277015303 ABC-ATPase subunit interface; other site 745277015304 dimer interface [polypeptide binding]; other site 745277015305 putative PBP binding regions; other site 745277015306 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 745277015307 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 745277015308 ABC-ATPase subunit interface; other site 745277015309 dimer interface [polypeptide binding]; other site 745277015310 putative PBP binding regions; other site 745277015311 tryptophan permease; Provisional; Region: PRK10483 745277015312 aromatic amino acid transport protein; Region: araaP; TIGR00837 745277015313 Pirin-related protein [General function prediction only]; Region: COG1741 745277015314 Pirin; Region: Pirin; pfam02678 745277015315 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 745277015316 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 745277015317 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 745277015318 H+ Antiporter protein; Region: 2A0121; TIGR00900 745277015319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277015320 putative substrate translocation pore; other site 745277015321 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 745277015322 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 745277015323 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745277015324 C factor cell-cell signaling protein; Provisional; Region: PRK09009 745277015325 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 745277015326 NADP binding site [chemical binding]; other site 745277015327 homodimer interface [polypeptide binding]; other site 745277015328 active site 745277015329 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 745277015330 fumarate hydratase; Provisional; Region: PRK15389 745277015331 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 745277015332 Fumarase C-terminus; Region: Fumerase_C; pfam05683 745277015333 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 745277015334 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 745277015335 transmembrane helices; other site 745277015336 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 745277015337 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 745277015338 putative active site [active] 745277015339 putative FMN binding site [chemical binding]; other site 745277015340 putative substrate binding site [chemical binding]; other site 745277015341 putative catalytic residue [active] 745277015342 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 745277015343 L-aspartate oxidase; Provisional; Region: PRK06175 745277015344 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 745277015345 ApbE family; Region: ApbE; pfam02424 745277015346 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 745277015347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 745277015348 active site 745277015349 phosphorylation site [posttranslational modification] 745277015350 intermolecular recognition site; other site 745277015351 dimerization interface [polypeptide binding]; other site 745277015352 sensory histidine kinase DcuS; Provisional; Region: PRK11086 745277015353 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 745277015354 putative active site [active] 745277015355 heme pocket [chemical binding]; other site 745277015356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 745277015357 ATP binding site [chemical binding]; other site 745277015358 Mg2+ binding site [ion binding]; other site 745277015359 G-X-G motif; other site 745277015360 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 745277015361 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 745277015362 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 745277015363 Trp docking motif [polypeptide binding]; other site 745277015364 putative active site [active] 745277015365 oxidoreductase; Provisional; Region: PRK06128 745277015366 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 745277015367 NAD binding site [chemical binding]; other site 745277015368 metal binding site [ion binding]; metal-binding site 745277015369 active site 745277015370 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 745277015371 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 745277015372 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 745277015373 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 745277015374 putative active site [active] 745277015375 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 745277015376 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 745277015377 N-terminal plug; other site 745277015378 ligand-binding site [chemical binding]; other site 745277015379 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 745277015380 intersubunit interface [polypeptide binding]; other site 745277015381 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 745277015382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277015383 putative substrate translocation pore; other site 745277015384 POT family; Region: PTR2; cl17359 745277015385 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 745277015386 ArsC family; Region: ArsC; pfam03960 745277015387 catalytic residues [active] 745277015388 arsenical pump membrane protein; Provisional; Region: PRK15445 745277015389 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 745277015390 transmembrane helices; other site 745277015391 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 745277015392 dimerization interface [polypeptide binding]; other site 745277015393 putative DNA binding site [nucleotide binding]; other site 745277015394 putative Zn2+ binding site [ion binding]; other site 745277015395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 745277015396 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 745277015397 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 745277015398 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 745277015399 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 745277015400 YebG protein; Region: YebG; pfam07130 745277015401 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 745277015402 B3/4 domain; Region: B3_4; pfam03483 745277015403 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 745277015404 SnoaL-like domain; Region: SnoaL_3; pfam13474 745277015405 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 745277015406 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 745277015407 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 745277015408 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 745277015409 dimerization interface [polypeptide binding]; other site 745277015410 trehalase; Provisional; Region: treF; PRK13270 745277015411 Trehalase; Region: Trehalase; cl17346 745277015412 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 745277015413 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 745277015414 active site 745277015415 homotetramer interface [polypeptide binding]; other site 745277015416 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 745277015417 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 745277015418 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 745277015419 Right handed beta helix region; Region: Beta_helix; pfam13229 745277015420 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 745277015421 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 745277015422 Protein of unknown function (DUF535); Region: DUF535; pfam04393 745277015423 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 745277015424 active site 745277015425 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 745277015426 Protein of unknown function (DUF796); Region: DUF796; cl01226 745277015427 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 745277015428 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 745277015429 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 745277015430 putative active site [active] 745277015431 metal binding site [ion binding]; metal-binding site 745277015432 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 745277015433 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 745277015434 putative ligand binding site [chemical binding]; other site 745277015435 Uncharacterized conserved protein [Function unknown]; Region: COG5276 745277015436 EamA-like transporter family; Region: EamA; pfam00892 745277015437 EamA-like transporter family; Region: EamA; pfam00892 745277015438 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 745277015439 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 745277015440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277015441 Major Facilitator Superfamily; Region: MFS_1; pfam07690 745277015442 putative substrate translocation pore; other site 745277015443 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 745277015444 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 745277015445 inhibitor site; inhibition site 745277015446 active site 745277015447 dimer interface [polypeptide binding]; other site 745277015448 catalytic residue [active] 745277015449 CblD like pilus biogenesis initiator; Region: CblD; cl06460 745277015450 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 745277015451 Chordopoxvirus G3 protein; Region: Chordopox_G3; cl17332 745277015452 CS1 type fimbrial major subunit; Region: Fimbrial_CS1; cl04524 745277015453 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 745277015454 putative fimbrial protein TcfA; Provisional; Region: PRK15308 745277015455 Virulence factor SrfB; Region: SrfB; pfam07520 745277015456 Putative bacterial virulence factor; Region: Virul_Fac; pfam10139 745277015457 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 745277015458 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 745277015459 putative active site; other site 745277015460 catalytic residue [active] 745277015461 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 745277015462 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 745277015463 nucleotide binding site [chemical binding]; other site 745277015464 putative NEF/HSP70 interaction site [polypeptide binding]; other site 745277015465 SBD interface [polypeptide binding]; other site 745277015466 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 745277015467 DnaJ domain; Region: DnaJ; pfam00226 745277015468 HSP70 interaction site [polypeptide binding]; other site 745277015469 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 745277015470 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 745277015471 active site 745277015472 Na/Ca binding site [ion binding]; other site 745277015473 catalytic site [active] 745277015474 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 745277015475 proline/glycine betaine transporter; Provisional; Region: PRK10642 745277015476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 745277015477 putative substrate translocation pore; other site 745277015478 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 745277015479 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 745277015480 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 745277015481 hypothetical protein; Provisional; Region: PRK09273 745277015482 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 745277015483 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 745277015484 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 745277015485 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 745277015486 NADP binding site [chemical binding]; other site 745277015487 homodimer interface [polypeptide binding]; other site 745277015488 active site 745277015489 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 745277015490 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277015491 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277015492 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 745277015493 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 745277015494 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 745277015495 Predicted transcriptional regulator [Transcription]; Region: COG1959 745277015496 Transcriptional regulator; Region: Rrf2; pfam02082 745277015497 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 745277015498 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 745277015499 trimer interface [polypeptide binding]; other site 745277015500 eyelet of channel; other site 745277015501 acetoin reductase; Validated; Region: PRK08643 745277015502 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 745277015503 NAD binding site [chemical binding]; other site 745277015504 homotetramer interface [polypeptide binding]; other site 745277015505 homodimer interface [polypeptide binding]; other site 745277015506 active site 745277015507 substrate binding site [chemical binding]; other site 745277015508 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 745277015509 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 745277015510 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 745277015511 TetR family transcriptional regulator; Provisional; Region: PRK14996 745277015512 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 745277015513 Tannase and feruloyl esterase; Region: Tannase; pfam07519 745277015514 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 745277015515 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 745277015516 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 745277015517 Methyltransferase domain; Region: Methyltransf_31; pfam13847 745277015518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 745277015519 S-adenosylmethionine binding site [chemical binding]; other site 745277015520 Tar ligand binding domain homologue; Region: TarH; pfam02203 745277015521 dimer interface [polypeptide binding]; other site 745277015522 ligand binding site [chemical binding]; other site 745277015523 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 745277015524 dimerization interface [polypeptide binding]; other site 745277015525 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 745277015526 dimer interface [polypeptide binding]; other site 745277015527 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 745277015528 putative CheW interface [polypeptide binding]; other site 745277015529 Protein of unknown function (DUF770); Region: DUF770; pfam05591 745277015530 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 745277015531 Protein of unknown function (DUF877); Region: DUF877; pfam05943 745277015532 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 745277015533 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 745277015534 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 745277015535 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 745277015536 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 745277015537 ligand binding site [chemical binding]; other site 745277015538 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 745277015539 Domain of unknown function DUF29; Region: DUF29; pfam01724 745277015540 Helix-turn-helix domain; Region: HTH_17; pfam12728 745277015541 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 745277015542 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 745277015543 Protein of unknown function (DUF2419); Region: DUF2419; pfam10343 745277015544 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 745277015545 Protein of unknown function (DUF1471); Region: DUF1471; cl11507