-- dump date 20120504_160039 -- class Genbank::CDS -- table cds_note -- id note NP_942646.1 Orf4; component of membrane-bound hydrogenase gene cluster NP_942661.1 transcriptional activator (NtrC family) of hydrogenase genes NP_942665.1 NiCoT family; TC 2.A.52 NP_942666.1 sedoheptulose-1,7-bisphosphate phosphatase NP_942667.1 similar to Ralstonia solanacearum outer membrane receptor NP_521043 NP_942668.1 similar to Azotobacter vinelandii gi:23105644 NP_942669.1 similar to Ralstonia metallidurans gi:22976888 NP_942670.1 similar to Ralstonia metallidurans gi:22976848 NP_942671.1 OrfA; similar to Ralstonia solanacearum ISRS08 transposase ORFA protein (NP_518700) NP_942672.1 similar to Azotobacter vinelandii gi:23106128 NP_942673.1 similar to Sinorhizobium meliloti integrase/recombinase, C-terminus (NP_436130)) NP_942674.1 similar to Rhizobium sp. NGR234 integrase/recombinase Y4RA, N-terminus (NC_000914) NP_942675.1 similar to Rhizobium sp. NGR234 integrase/recombinase Y4RA (NP_444039)) NP_942676.1 similar to Rhizobium sp. NGR234 integrase/recombinase Y4RB (NP_444040) NP_942677.1 similar to Rhizobium sp. NGR234 integrase/recombinase Y4RC (NP_444041) NP_942678.1 similar to Rhizobium sp. NGR234 integrase/recombinase Y4RC, C-terminus (NP_444041) NP_942679.1 similar to Rhizobium sp. NGR234 integrase/recombinase Y4RC (NP_444041)) NP_942680.1 similar to Rhizobium sp. NGR234 integrase/recombinase Y4RB (NP_444040)) NP_942681.1 ISAE1 Orf2 fused to integrase/recombinase similar to Rhizobium sp. NGR234 Y4RA (NP_444039) NP_942682.1 similar to GenBank Accession gi:141951 NP_942683.1 similar to Rhizobium sp. NGR234 integrase/recombinase Y4RC (NP_444041) NP_942684.1 similar to Rhizobium sp. NGR234 integrase/recombinase Y4RB (NP_444040) NP_942685.1 similar to Rhizobium sp. NGR234 integrase/recombinase Y4RA (NP_444039) NP_942686.1 similar to Sinorhizobium meliloti integrase/recombinase (NP_436129) NP_942687.1 similar to Sinorhizobium meliloti integrase/recombinase (NP_436128) NP_942688.1 similar to Azotobacter vinelandii gi:23102428 NP_942689.1 similar to Ralstonia eutropha HoxW, N-terminus (X92988) NP_942690.1 similar to Acinetobacter haemolyticus transposase (AAB67318) NP_942691.1 predicted by FrameD NP_942692.1 similar to Xanthomonas axonopodis pv. citri str. 306 gi:21244652 NP_942693.1 predicted by FrameD NP_942694.1 predicted by FrameD NP_942695.1 similar to Mesorhizobium loti integrase/recombinase (NP_106607) NP_942696.1 similar to Mesorhizobium loti integrase/recombinase (NP_085858) NP_942697.1 similar to Mesorhizobium loti integrase/recombinase (NP_106768) NP_942698.1 similar to Xanthomonas axonopodis pv. citri str. 306 gi:21244651 NP_942699.1 similar to Vibrio cholerae gi:11139679 NP_942700.1 similar to Ralstonia solanacearum IS1021 transposase, C-terminus (NP_521767) NP_942701.1 similar to Ralstonia solanacearum IS1021 transposase, N-terminus (NP_521767) NP_942702.1 NiCoT family; TC 2.A.52 NP_942703.1 similar to Streptomyces avermitilis hydrogenase (BAB69211) NP_942704.1 similar to Streptomyces avermitilis hydrogenase NP_942705.1 similar to Chloroflexus aurantiacus gi:22974151 NP_942706.1 predicted by FrameD NP_942707.1 predicted by FrameD NP_942708.1 predicted by FrameD NP_942709.1 similar to Aquifex aeolicus hydrogenase maturation protein NP_942710.1 predicted by FrameD NP_942711.1 similar to Thiocapsa roseopersicina (AAK56850) and Nostoc sp. PCC 7120 HypF (NP_484737) NP_942712.1 similar to Nostoc sp. PCC 7120 HypC (NP_484738) NP_942713.1 similar to Clostridium acetobutylicum phosphoheptose isomerase (NP_349654) NP_942714.1 similar to Nostoc punctiforme HypD (AAG49378) NP_942715.1 similar to Nostoc punctiforme HypE (AAG49379) NP_942716.1 similar to Nostoc sp. PCC 7120 hydrogenase expression/formation protein (NP_484742) NP_942717.1 similar to Nostoc sp. PCC 7120 'hydrogenase expression/formation protein' (NP_484743) NP_942718.1 similar to Ralstonia metallidurans gi:22978641 NP_942719.1 similar to Ralstonia metallidurans gi:22978641 NP_942720.1 similar to C-terminus of histidine protein kinases similar to Ralstonia metallidurans gi:22975230 NP_942721.1 similar to Mesorhizobium loti integrase/recombinase, C-terminus (NP_106529) NP_942722.1 similar to Mesorhizobium loti integrase/recombinase, central part (NP_106768) NP_942723.1 Pfam entry PF01527; similar to Ralstonia metallidurans gi:22975527 NP_942724.1 similar to Burkholderia fungorum gi:22986320 NP_942725.1 similar to Burkholderia fungorum gi:22986320 NP_942726.1 Pfam entry PF04986; similar to Mesorhizobium loti transposase, central part gi:13475379 NP_942736.1 similar to Escherichia coli hypothetical protein (AAK09054) NP_942737.1 similar to Ralstonia metallidurans gi:22979938 NP_942738.1 similar to Ralstonia metallidurans gi:22975810 NP_942739.1 Orf2 NP_942741.1 predicted by FrameD NP_942742.1 predicted by FrameD NP_942743.1 predicted by FrameD NP_942744.1 similar to Pseudomonas sp. ADP KfrA protein (AAK50247) NP_942745.1 similar to Ralstonia solanacearum conserved hypothetical protein (NP_522594); HNS domain (aa 43-88) NP_942746.1 SMART domain SM00221; similar to Vibrio vulnificus cmcp6 gi:27367537 NP_942747.1 similar to Rhodobacter sphaeroides gi:22956745 NP_942748.1 SMART domain SM00382; similar to Rhizobium etli gi:21492959; AAA-family NP_942749.1 FrameD prediction picked ORF start at codon 60; ATG picked further upstream based on BLASTP; similar to Rhizobium etli gi:21492958, Agrobacterium tumefaciens gi:16119897 NP_942750.1 FrameD prediction picked ORF start at codon 127; ATG picked further upstream based on BLASTP; similar to Rhodobacter sphaeroides gi:22957917, Porphyromonas gingivalis gi:03859861 NP_942751.1 similar to Bradyrhizobium japonicum gi:27379007 NP_942752.1 similar to Burkholderia fungorum gi:22983463 NP_942753.1 FrameD prediction picked ORF start at codon 36; ATG picked further upstream based on BLASTP; similar to Mesorhizobium loti gi:13476738, Sinorhizobium meliloti gi:15963938 NP_942754.1 FrameD prediction picked ORF start at codon 38; ATG picked further upstream based on BLASTP; similar to Sinorhizobium meliloti gi:15963937, Mesorhizobium loti gi:13476739; integral membrane protein NP_942755.1 TC 2.A.72; FrameD prediction picked ORF start at codon 20; ATG picked further upstream based on BLASTP, similar to Ralstonia metallidurans gi:22978665, Ralstonia solanacearum gi:17546340 NP_942757.1 similar to Myxococcus xanthus gi:21464490 NP_942758.1 similar to Ralstonia solanacearum gi:17549866 NP_942759.1 Pfam entry PF03328; similar to Pectobacterium chrysanthemi gi:16118728, Pseudomonas syringae pv. syringae b728a gi:23468419 NP_942760.1 Pfam entry PF02784; similar to Xanthomonas campestris pv. campestris str. atcc 33 gi:21232485 NP_942761.1 similar to Xanthomonas axonopodis gi:21243906, Vibrio parahaemolyticus gi:23307118 NP_942762.1 similar to Xanthomonas campestris gi:21232483, Vibrio parahaemolyticus gi:23307117; transmembrane NP_942763.1 similar to Xanthomonas campestris pv. campestris str. atcc 33 gi:21232482 NP_942764.1 FrameD prediction picked ORF start at codon 32; ATG picked further upstream based on BLASTP; similar to Azotobacter vinelandii gi:23101930, Xanthomonas campestris pv. campestris str. atcc 33 gi:21232481 NP_942765.1 FrameD prediction picked ORF start at codon 25; ATG picked further upstream based on BLASTP and SD sequence; similar to Pseudomonas putida kt2440 gi:26990323, Ralstonia solanacearum gi:17549283; Pfam:TonB_boxC NP_942766.1 similar to Ralstonia solanacearum gi:17548929, Ralstonia metallidurans gi:22978149 NP_942767.1 similar to Pseudomonas syringae pv. syringae b728a gi:23471514 NP_942768.1 similar to Ralstonia eutropha plasmid pAE1-encoded integrase/recombinase gi:02120948 NP_942769.1 similar to Mesorhizobium loti gi:13474968 NP_942771.1 similar to Ralstonia eutropha plasmid pAE1-encoded hypothetical 21.6 kDa protein gi:02120946 NP_942772.1 similar to Mesorhizobium loti gi:13474966 NP_942773.1 similar to Rhizobium sp. ngr234 gi:16519919 NP_942774.1 similar to Rhizobium sp. ngr234 gi:16519921 NP_942775.1 similar to Mesorhizobium loti gi:13474966 NP_942776.1 similar to Rastonia eutropha plasmid pAE1-encoded hypothetical 21.6 kDa protein gi:02120946 NP_942778.1 similar to Mesorhizobium loti gi:13474968 NP_942779.1 similar to Ralstonia eutropha plasmid pAE1-encoded integrase/recombinase gi:02120948 NP_942780.1 Pfam PF03050; similar to Magnetococcus sp. mc-1 gi:23001527 NP_942782.1 similar to Burkholderia fungorum gi:22982816; secreted or periplasmic NP_942783.1 Pfam entry PF01526; similar to Pseudomonas sp. adp gi:13937463 NP_942784.1 similar to Burkholderia fungorum gi:22983421 NP_942785.1 similar to Escherichia coli o157:h- gi:18026930 NP_942786.1 similar to Escherichia coli o157:h- gi:18026930 NP_942788.1 similar to Micrococcus sp. 28 gi:18025393 NP_942789.1 similar to Bradyrhizobium japonicum gi:27379743 NP_942790.1 helicase-like; Pfam entry PF00580; similar to Micrococcus sp. 28 gi:18025395 NP_942794.1 similar to Deinococcus radiodurans gi:15806559 NP_942795.1 similar to Ralstonia solanacearum gi:17549254 NP_942796.1 similar to Shigella flexneri 2a gi:15808733 NP_942797.1 similar to Shigella flexneri 2a str. 301 gi:24111814 NP_942798.1 Pfam entry PF03050; similar to Escherichia coli gi:14252930 NP_942801.1 similar to Streptomyces coelicolor a3(2) gi:21234012 NP_942802.1 SMART domain SM00020; serine protease-like NP_942803.1 Pfam entry PF00753; similar to Yersinia enterocolitica gi:05420075; metallo-beta-lactamase superfamily NP_942804.1 similar to Xanthomonas campestris pv. campestris str. atcc 33 gi:21231075 NP_942805.1 Pfam entry PF00580; similar to Pseudomonas putida kt2440 gi:26990390 NP_942806.1 Pfam entry PF02463; similar to Microbulbifer degradans 2-40 gi:23027981 NP_942807.1 similar to Vibrio vulnificus cmcp6 gi:27367741 NP_942808.1 SMART domain SM00399; similar to Deinococcus radiodurans gi:15805614 NP_942810.1 similar to Mesorhizobium loti gi:13488359 NP_942813.1 similar to Methanosarcina mazei goe1 gi:21227582 NP_942814.1 similar to Mycobacterium tuberculosis h37rv gi:15609238 NP_942815.1 similar to Burkholderia fungorum gi:22984663 NP_942816.1 similar to Ralstonia eutropha gi:03641686 NP_942818.1 similar to Ralstonia solanacearum gi:17548556 NP_942819.1 similar to Haemophilus somnus 129pt gi:23467771 NP_942820.1 similar to Helicobacter pylori 26695 gi:15645609 NP_942821.1 SMART:HTH_XRE; XRE family NP_942822.1 similar to Sinorhizobium meliloti gi:16262700 NP_942823.1 similar to Pseudomonas syringae pv. syringae b728a gi:23470717; histidine protein kinase NP_942824.1 similar to Azotobacter vinelandii gi:23101871 NP_942825.1 Pfam:PIN similar to Bradyrhizobium japonicum gi:27377545 NP_942826.1 similar to Ralstonia solanacearum gi:17546566 NP_942827.1 SMART:phage-integrase WU-BLAST2:integrase similar to Ralstonia solanacearum gi:17546565 NP_942828.1 similar to Ralstonia solanacearum gi:17546564 NP_942829.1 similar to Ralstonia solanacearum gi:17546563 NP_942831.1 similar to Rhodospirillum rubrum gi:22965786 NP_942832.1 similar to Mesorhizobium loti gi:13488211 NP_942834.1 similar to Ralstonia solanacearum gi:17547034 NP_942835.1 similar to Bradyrhizobium japonicum gi:27377582 NP_942837.1 similar to N-terminus of Pseudomonas fluorescens gi:23060226; response regulator NP_942838.1 flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine NP_942839.1 N-terminus similar to central part of Ralstonia metallidurans gi:22977826 NP_942840.1 similar to Burkholderia fungorum gi:22990143 NP_942841.1 similar to C-terminus of fumarate reductase flavoprotein subunits; Streptococcus mutans gi:24378694, Clostridium tetani gi:28211164 NP_942844.1 similar to Burkholderia fungorum gi:22988055, Ralstonia metallidurans gi:22978336 NP_942845.1 similar to C-terminus of transposases; Mesorhizobium loti gi:13488118, Escherichia coli gi:18265863 NP_942846.1 similar to C-terminus of transposases; Geobacter metallireducens gi:23056465; Pfam:Transposase_20 NP_942849.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC NP_942851.1 Pfam entry PF03264 NP_942852.1 ATP-binding protein; required for proper cytochrome c maturation NP_942855.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane NP_942858.1 FrameD picked start at codon 8, start picked further upstream based on alignment NP_942860.1 similar to Ralstonia solanacearum gi:17546739, Burkholderia fungorum gi:22983219 NP_942861.1 similar to C-terminus of transposases; Sphingomonas sp. gi:05578707, Paracoccus pantotrophus gi:27802461 NP_942862.1 similar to N-terminus of Ralstonia metallidurans gi:22976193 NP_942863.1 similar to central part of Ralstonia solanacearum gi:17544920, Ralstonia metallidurans gi:22976194 NP_942864.1 similar to N-terminus of Ralstonia solanacearum gi:17544920, Ralstonia metallidurans gi:22976194 NP_942865.1 transmembrane protein, similar to C-terminus of Ralstonia solanacearum gi:17544901, Pseudomonas fluorescens gi:23062939; Pfam entry PF02308 NP_942866.1 probable universal stress protein, similar to Ralstonia metallidurans gi:22976196, Ralstonia solanacearum gi:17546223, gi:17544898; Pfam entry PF00582 NP_942867.1 similar to N-terminus of Ralstonia solanacearum gi:17546224, Burkholderia fungorum gi:22984140; Pfam entry PF00107 NP_942868.1 similar to C- terminus of Ralstonia solanacearum gi:17546224, Brucella melitensis gi:17987208 NP_942869.1 phosphoribosyltransferase, similar to Thermobifida fusca gi:23019923, Mycobacterium tuberculosis cdc1551 gi:15839969, Mycobacterium tuberculosis h37rv gi:15607711; Pfam entry PF00156 NP_942870.1 similar to central part of Ralstonia solanacearum gi:17544995, Ralstonia metallidurans gi:22978769, Brucella suis 1330 gi:23500197 NP_942871.1 similar to Neisseria meningitidis z2491 gi:15794625, Haemophilus influenzae rd gi:16272203 NP_942872.1 similar to Agrobacterium tumefaciens gi:15890598, Clostridium acetobutylicum gi:15893369 NP_942873.1 similar to Burkholderia fungorum gi:22983334, Ralstonia solanacearum gi:17548114 NP_942874.1 transmembrane protein; similar to Magnetospirillum magnetotacticum gi:23014193, Chloroflexus aurantiacus gi:22971297 NP_942875.1 similar to Lactococcus lactis subsp. lactis gi:15672865, Magnetospirillum magnetotacticum gi:23014194 NP_942877.1 similar to Ralstonia metallidurans gi:22980091, Ralstonia solanacearum gi:17549185 NP_942878.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates NP_942880.1 Involved in anaerobic NO protection and iron metabolism NP_942881.1 Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon NP_942884.1 Pfam entry PF00005 NP_942887.1 reduces nitrous oxide to nitrogen NP_942889.1 similar to AbpE thiamine biosynthesis proteins; FrameD picked start at codon 46, start picked further upstream based on BLASTP NP_942890.1 similar to Ralstonia metallidurans gi:22975508, Ralstonia solanacearum gi:17549189 NP_942891.1 similar to Ralstonia metallidurans gi:22975507, Ralstonia solanacearum gi:17549190 NP_942892.1 similar to Ralstonia metallidurans gi:22975506, Ralstonia solanacearum gi:17549191; Pfam entry PF01136 NP_942893.1 similar to Ralstonia metallidurans gi:22978238, Ralstonia solanacearum gi:17544833; FrameD picked start 5 codons further upstream, start picked based on ribosome binding site; Pfam entry PF03060 NP_942894.1 similar to Ralstonia solanacearum gi:17549188, Klebsiella pneumoniae gi:03758876 NP_942896.1 similar to Burkholderia fungorum gi:22982236, Ralstonia metallidurans gi:22975990 NP_942897.1 Dnr/Nnr subgroup of Fnr like transcriptional regulators, similar to Ralstonia solanacearum gi:17549187, Pseudomonas stutzeri gi:04585799 NP_942898.1 transmembrane protein, similar to Ralstonia metallidurans gi:22978237, Ralstonia solanacearum gi:17549192 NP_942899.1 similar to Ralstonia metallidurans gi:22978236, Aquifex aeolicus gi:15606247 NP_942900.1 NarX/NarL two component system; Pfam entries PF03059 and PF02518 NP_942901.1 NarX/NarL two component system; Pfam entries PF00196 and PF00072 NP_942902.1 transmembrane protein, similar to Ralstonia solanacearum gi:17548116, Ralstonia metallidurans gi:22977478 NP_942905.1 Pfam entries PF00384 and PF01568 NP_942906.1 Pfam entry PF00037 NP_942907.1 Pfam entry PF02613 NP_942908.1 Pfam entry PF02665 NP_942909.1 similar to Brucella melitensis gi:17989299, Brucella suis 1330 gi:23500050; Pfam entry PF00639 NP_942910.1 similar to Ralstonia solanacearum gi:17549199, Bradyrhizobium japonicum gi:27377422 NP_942911.1 FrameD prediction picked ORF start at codon 52; ATG picked further upstream based on BLASTP NP_942912.1 similar to N-terminus of Rhizobium sp. NGR234 gi:02497415, Mesorhizobium loti gi:13488149 NP_942913.1 similar to Nostoc punctiforme gi:23125941; Pfam entries PF00672, PF00989 and PF00211 NP_942914.1 similar to Rhodospirillum rubrum gi:02346994, Shewanella oneidensis mr-1 gi:24376250 NP_942915.1 similar to Nitrosomonas europaea gi:22955015, Shewanella oneidensis mr-1 gi:24376248; Pfam entry PF01909 NP_942918.1 similar to c-terminus of Coxiella burnetii gi:10955994 NP_942921.1 similar to Ralstonia solanacearum gi:17549323, Burkholderia fungorum gi:22983374 NP_942922.1 similar to Ralstonia metallidurans gi:22980858, gi:22979284; bacterial histone like domain; Pfam entry PF00216 NP_942924.1 similar to Ralstonia metallidurans gi:22980877, Chloroflexus aurantiacus gi:22971274 NP_942925.1 similar to Ralstonia metallidurans gi:22980878 NP_942926.1 similar to Ralstonia metallidurans gi:22980879, Thermosynechococcus elongatus bp-1 gi:22299520 NP_942927.1 similar to Ralstonia metallidurans gi:22980880 NP_942930.1 similar to C-terminus of Ralstonia metallidurans gi:22980881 NP_942932.1 similar to Ralstonia metallidurans gi:22980882 NP_942934.1 similar to Ralstonia metallidurans gi:22980883, Pseudomonas putida kt2440 gi:26989219 NP_942935.1 similar to Ralstonia metallidurans gi:22980884 NP_942936.1 C-terminus similar to Ralstonia metallidurans gi:22980885 NP_942937.1 similar to Ralstonia metallidurans gi:22980886 NP_942940.1 similar to C-terminus of Ralstonia metallidurans gi:22980887, Ralstonia solanacearum gi:17547511 NP_942941.1 Pfam entry PF00899; similar to Ralstonia metallidurans gi:22980890; ThiF family NP_942942.1 similar to Ralstonia metallidurans gi:22980891 NP_942943.1 similar to Ralstonia metallidurans gi:22980892 NP_942944.1 similar to Ralstonia metallidurans gi:22980893 NP_942945.1 similar to Ralstonia metallidurans gi:22980894 NP_942946.1 similar to Ralstonia metallidurans gi:22980895 NP_942947.1 similar to Ralstonia metallidurans gi:22980896; ParB family NP_942949.1 Synechocystis sp. pcc 6803 gi:16332119 NP_942952.1 similar to Ralstonia metallidurans gi:22980898 NP_942954.1 similar to Ralstonia metallidurans gi:22980900 NP_942956.1 similar to Ralstonia metallidurans gi:22980901 NP_942957.1 similar to Ralstonia metallidurans gi:22980902 NP_942958.1 similar to Ralstonia metallidurans gi:22980903 NP_942959.1 similar to Ralstonia metallidurans gi:22980915 NP_942960.1 Pfam entry PF01555; similar to Ralstonia metallidurans gi:22980916 NP_942961.1 similar to Ralstonia metallidurans gi:22980918 NP_942962.1 SMART domain SM00477; similar to Ralstonia metallidurans gi:22980919 NP_942963.1 similar to Ralstonia solanacearum gi:17548076 NP_942964.1 Pfam entry PF02954; similar to Azotobacter vinelandii gi:23104622; FIS family NP_942965.1 similar to Ralstonia metallidurans gi:22980922; secreted or periplasmic NP_942966.1 similar to Acidithiobacillus ferrooxidans gi:10945166 NP_942969.1 similar to Salmonella typhimurium lt2 gi:16764263 NP_942970.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA NP_942971.1 similar to Ralstonia metallidurans gi:22980925 NP_942972.1 similar to Ralstonia metallidurans gi:22980926 NP_942973.1 similar to Ralstonia metallidurans gi:22980928 NP_942974.1 similar to Ralstonia metallidurans gi:22980929 NP_942977.1 similar to Xanthomonas campestris pv. campestris str. atcc 33 gi:21230755; secreted or periplasmic NP_942978.1 Salmonella enterica subsp. enterica serovar dublin gi:08896035 NP_942979.1 integral membrane protein NP_942982.1 Pfam entry PF00482; similar to Escherichia coli gi:10955359; gspF family NP_942983.1 Pfam entry PF00437; similar to Escherichia coli gi:15667834 NP_942984.1 similar to Salmonella enterica subsp. enterica serovar typhi gi:16763014 NP_942985.1 similar to Sinorhizobium meliloti gi:15966805; secreted or periplasmic NP_942986.1 Pfam entry PF00263; similar to Escherichia coli gi:10955355; GspD family NP_942987.1 similar to Ralstonia metallidurans gi:22980938 NP_942988.1 Pfam entry PF01464; similar to Ralstonia metallidurans gi:22980939 NP_942989.1 similar to Ralstonia metallidurans gi:22980940 NP_942990.1 similar to Ralstonia metallidurans gi:22980941 NP_942991.1 similar to Ralstonia metallidurans gi:22980942 NP_942992.1 similar to Ralstonia metallidurans gi:22980943 NP_942993.1 similar to Ralstonia metallidurans gi:22980944; secreted or periplasmic NP_942994.1 Pfam:GSPII_E(37-313) similar to Ralstonia metallidurans gi:22980945 NP_942995.1 similar to Ralstonia metallidurans gi:22980946 NP_942996.1 similar to Ralstonia metallidurans gi:22980947 NP_942997.1 similar to Ralstonia metallidurans gi:22980948; integral membrane protein NP_942998.1 similar to Ralstonia metallidurans gi:22980949; integral membrane protein NP_942999.1 similar to Ralstonia metallidurans gi:22980950 NP_943000.1 Providencia rettgeri gi:20095137 NP_943001.1 similar to Ralstonia metallidurans gi:22980952; TraG family; TC 3.A.7 NP_943002.1 similar to Ralstonia metallidurans gi:22980953 NP_943003.1 similar to Ralstonia metallidurans gi:22980954 NP_943004.1 similar to Ralstonia metallidurans gi:22980955 NP_943006.1 Pfam entry PF00580; similar to Leuconostoc citreum gi:08928266 NP_943007.1 similar to Ralstonia metallidurans gi:02120964 NP_943008.1 similar to Paracoccus versutus gi:18029507 NP_943009.1 Pfam entry PF00991; similar to Burkholderia fungorum gi:22990152 NP_943010.1 SMART domain SM00470; similar to Burkholderia fungorum gi:22990151 NP_943011.1 Pfam entry PF00589; similar to Ralstonia metallidurans gi:22980584; xerD family NP_943015.1 similar to Nostoc sp. pcc 7120 gi:17230704 NP_943016.1 similar to Deinococcus radiodurans gi:15805444 NP_943017.1 Pfam entry UPF0065; similar to Agrobacterium tumefaciens gi:15890266 NP_943018.1 SMART domains SM00091, SM00086 and SM00044; similar to Nostoc sp. pcc 7120 gi:17228157; bZIP histidine kinase NP_943019.1 similar to Ralstonia eutropha gi:2808587 NP_943020.1 similar to Ralstonia eutropha gi:02808586 NP_943021.1 similar to Ralstonia eutropha gi:07387890; TC 2.A.1; major facilitator superfamily NP_943022.1 Pfam entry PF01144; similar to Pseudomonas putida kt2440 gi:26990657 NP_943023.1 Pfam entry PF01144; similar to Ralstonia solanacearum gi:17546973 NP_943024.1 Pfam entries PF00126 and PF03466; similar to Salmonella typhimurium lt2 gi:16764221; LysR-type NP_943025.1 similar to Streptomyces coelicolor a3(2) gi:21225070; metallo-beta-lactamase superfamily NP_943026.1 similar to Incl/m plasmid r471a gi:02688957 NP_943027.1 Pfam entry UPF0065; similar to Ralstonia metallidurans gi:22976733 NP_943028.1 similar to Ralstonia eutropha gi:11967280 NP_943029.1 similar to Ralstonia eutropha gi:11967279 NP_943030.1 Pfam entry PF03060; similar to Ralstonia solanacearum gi:17544974 NP_943031.1 Pfam entry UPF0065; similar to Ralstonia metallidurans gi:22977461 NP_943032.1 Pfam entry PF01575; similar to Archaeoglobus fulgidus gi:11499894; MaoC family NP_943033.1 activates fatty acids by binding to coenzyme A NP_943034.1 activates fatty acids by binding to coenzyme A NP_943035.1 Pfam entry UPF0065; similar to Bradyrhizobium japonicum gi:27382172 NP_943036.1 LysR-type; Pfam entries PF00126, PF03466 and PF01047; similar to Ralstonia metallidurans gi:22978581 NP_943037.1 Pfam entry UPF0065; similar to Ralstonia metallidurans gi:22976057 NP_943038.1 Pfam entry UPF0065;similar to Ralstonia metallidurans gi:22976733 NP_943039.1 similar to Ralstonia eutropha gi:11967280 NP_943040.1 similar to Ralstonia eutropha gi:11967279 NP_943041.1 LysR-type; similar to Burkholderia sp. nk8 gi:12539416 NP_943042.1 similar to plasmid r100 gi:09507558; Tn21 family NP_943043.1 similar to Ralstonia metallidurans gi:22979812; Tn21 family NP_943044.1 Tn21 family NP_943046.1 similar to Ralstonia metallidurans gi:22980875; incomplete IS882-like element NP_943047.1 similar to Caulobacter crescentus cb15 gi:16126973 NP_943049.1 Pfam entry PF00070; similar to Bradyrhizobium japonicum gi:27378838 NP_943050.1 similar to Xanthomonas oryzae pv. oryzae gi:28173597 NP_943051.1 class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis NP_943052.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway NP_943054.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate NP_943057.1 seduheptolose-1,7-bisphosphate phosphatase NP_943062.1 type III RuBisCO; involved in carbon fixation YP_724521.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_724522.1 binds the polymerase to DNA and acts as a sliding clamp YP_724523.1 negatively supercoils closed circular double-stranded DNA YP_724536.1 DUF2; DUF1; EAL domain. This domain is found in diverse bacterial signaling proteins YP_724542.1 HhH2 YP_724549.1 3 TMHs YP_724550.1 2 TMHs YP_724551.1 11 TMHs YP_724560.1 4 TMHs YP_724561.1 predicted by FrameD YP_724564.1 catalyzes the formation of glutamate and formamide from N-formimidoyl-L-glutamate YP_724566.1 4 TMHs YP_724574.1 unknown EC_number=2.1.1.- YP_724576.1 2 TMHs YP_724579.1 exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA YP_724584.1 14 TMHs YP_724588.1 catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position YP_724590.1 12 TMHs YP_724595.1 10 TMHs YP_724600.1 REC (residues 8 to 116, 2e-12) with a typical phosphorylation pocket (1/2 DD,D54,S/T82,K105) YP_724601.1 REC (residues 11 to 122, 5e-19) with a typical phosphorylation pocket (DD,D54,S/T82,K105) YP_724603.1 OmpC Similar to Ralstonia solanacearum GI:17547810 YP_724604.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell YP_724606.1 blocks the formation of polar Z-ring septums YP_724607.1 2 TMHs YP_724623.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_724628.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_724631.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_724632.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain YP_724633.1 functions in MreBCD complex in some organisms YP_724634.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_724639.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_724640.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence YP_724642.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein YP_724643.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_724647.1 5 TMHs YP_724648.1 8 TMHs YP_724649.1 catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline YP_724654.1 5 TMHs YP_724655.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon YP_724656.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP YP_724662.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_724673.1 REC (residues 4 to 118, 3e-23) with a complete phosphorylation pocket (DD-D60-S94-K107) YP_724674.1 REC (residues 15 to 130, 5e-14) with a typical phosphorylation pocket (1/2 DD,D54,S/T82,K105) YP_724675.1 2 TMHs YP_724679.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_724688.1 catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol YP_724690.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_724699.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_724700.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate YP_724701.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine YP_724706.1 catalyzes the formation of acetoacetate and acetyl-CoA from 3-hydroxy-3-methylglutaryl-CoA YP_724719.1 heat shock protein involved in degradation of misfolded proteins YP_724720.1 heat shock protein involved in degradation of misfolded proteins YP_724722.1 REC (residues 19 to 139, 2e-17) with a complete phosphorylation pocket (DD-D56-T92-K106) YP_724723.1 6 TMHs YP_724726.1 4 TMHs YP_724728.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_724730.1 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly YP_724731.1 Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine YP_724738.1 12 TMHs YP_724740.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis YP_724744.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_724747.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_724748.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA YP_724749.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA YP_724750.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_724755.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine YP_724757.1 with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate YP_724758.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate YP_724764.1 catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine YP_724766.1 deleted EC_number 1.7.99.5 YP_724773.1 catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases YP_724780.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs YP_724783.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_724789.1 5 TMHs YP_724791.1 catalyzes the formation of pyruvate and beta-alanine from L-alanine and 3-oxopropanoate YP_724795.1 12 TMHs YP_724796.1 13 TMHs YP_724801.1 converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA YP_724806.1 8 TMHs YP_724807.1 10 TMHs YP_724813.1 part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation YP_724814.1 response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation YP_724816.1 REC (residues 11 to 123, 1e-21) with a typical phosphorylation pocket (1/2 DD,D54,S/T82,K105) YP_724818.1 involved in the transport of C4-dicarboxylates across the membrane YP_724828.1 5 TMHs YP_724831.1 14 TMHs YP_724835.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_724840.1 12 TMHs YP_724842.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione YP_724848.1 catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA YP_724851.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate YP_724854.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA YP_724855.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_724857.1 unknown EC_number=2.1.1.- YP_724859.1 unknown EC_number=2.1.1.- YP_724864.1 involved in the insertion of copper into subunit I of cytochrome C oxidase YP_724871.1 converts protoheme IX and farnesyl diphosphate to heme O YP_724873.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters YP_724877.1 6 TMHs YP_724879.1 AmiR YP_724885.1 unknown EC_number=2.1.1.- YP_724886.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_724889.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_724890.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_724891.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_724892.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_724893.1 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein YP_724895.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_724901.1 catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system YP_724904.1 unknown EC_number 2.7.76 YP_724905.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen YP_724910.1 11 TMHs YP_724913.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_724920.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA YP_724939.1 6 TMHs YP_724944.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis YP_724945.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway YP_724958.1 4 TMHs YP_724961.1 5 TMHs YP_724963.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone YP_724966.1 an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions YP_724967.1 unknown EC_number=2.1.1.- YP_724968.1 13 TMHs YP_724971.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_724973.1 converts dATP to dAMP and pyrophosphate YP_724980.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_724982.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_724984.1 6 TMHs YP_724987.1 5 TMHs YP_724991.1 4 TMHs YP_724992.1 5 TMHs YP_724997.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_725000.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_725001.1 forms a direct contact with the tRNA during translation YP_725003.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors YP_725006.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling YP_725007.1 1 TMHs YP_725008.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_725009.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_725012.1 4 TMHs YP_725015.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_725016.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_725018.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_725019.1 involved in de novo purine biosynthesis YP_725026.1 1 TMHs YP_725027.1 6 TMHs YP_725029.1 1 TMHs YP_725031.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) YP_725032.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_725033.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_725034.1 10 TMHs YP_725038.1 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate YP_725039.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_725040.1 conserved hypothetical protein YP_725041.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_725042.1 Transfers the fatty acyl group on membrane lipoproteins YP_725044.1 contains unknown N-terminal domain/ metalloprotease C-terminal domain YP_725046.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_725050.1 catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages YP_725054.1 REC (residues 4 to 118, 9e-12) with a typical phosphorylation pocket (1/2 DD,D54,S/T82,K105) YP_725057.1 11 TMHs YP_725058.1 2 TMHs YP_725059.1 2 TMHs YP_725060.1 REC (residues 3 to 115, 8e-25) with a complete phosphorylation pocket (DD-D48-S79-K96) YP_725061.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_725062.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities YP_725064.1 catalyzes the interconversion of succinyl-CoA and succinate YP_725065.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle YP_725069.1 3 TMHs YP_725071.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis YP_725074.1 2 TMHs YP_725078.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_725083.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_725084.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_725085.1 class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis YP_725086.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_725088.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_725091.1 6 TMHs YP_725099.1 9 TMHs YP_725100.1 9 TMHs YP_725102.1 REC (residues 9 to 121, 1e-27) with a complete phosphorylation pocket (DD-D55-S78-K96) YP_725103.1 2 TMHs YP_725104.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX YP_725106.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_725110.1 8 TMHs YP_725116.1 unknown EC_number=2.1.1.- YP_725119.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_725120.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS YP_725122.1 Transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate YP_725124.1 4 TMHs YP_725125.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_725127.1 11 TMHs YP_725159.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth YP_725172.1 VgrG protein, uncharacterized protein conserved inbacteria YP_725179.1 5 TMHs YP_725183.1 13 TMHs YP_725189.1 6 TMHs YP_725192.1 5 TMHs YP_725199.1 4 TMHs YP_725200.1 4 TMHs YP_725201.1 7 TMHs YP_725202.1 4 TMHs YP_725205.1 catalyzes the formation of L-proline from L-ornithine YP_725207.1 REC (residues 7 to 119, 1e-23) with a complete phosphorylation pocket (DD-D55-T75-K96) YP_725208.1 2 TMHs YP_725209.1 6 TMHs YP_725210.1 12 TMHs YP_725211.1 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism YP_725212.1 contains a MASE1 (Membrane-Associated Sensor) domain; potentially involved in signal transduction YP_725215.1 10 TMHs YP_725221.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_725222.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_725234.1 signal peptide YP_725236.1 4 TMHs YP_725241.1 2 TMHs YP_725242.1 4 TMHs YP_725243.1 unknown EC_number=2.1.1.- YP_725246.1 12 TMHs YP_725250.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_725252.1 REC (residues 37 to 151, 7e-26) with a complete phosphorylation pocket (DD-D55-S86-K98) YP_725253.1 REC (residues 7 to 121, 7e-25) with a complete phosphorylation pocket (DD-D66-S94-K108) YP_725255.1 2 TMHs YP_725256.1 REC (residues1805 to 1919, 6e-21) with a complete phosphorylation pocket (DD-D58-T80-K98) YP_725258.1 12 TMHs YP_725259.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_725260.1 2 TMHs YP_725262.1 catalyzes the hydrolysis of pyrophosphate to phosphate YP_725263.1 4 TMHs YP_725265.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_725267.1 7 TMHs YP_725270.1 5 TMHs YP_725271.1 participates with LolB in the incorporation of lipoprotein into the outer membrane YP_725277.1 12 TMHs YP_725280.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_725282.1 8 TMHs YP_725285.1 catalyzes the oxidative deamination of D-amino acids YP_725288.1 3 TMHs YP_725289.1 catalyze the formation of cyanophycin which may act to store excess nitrogen YP_725290.1 catalyze the formation of cyanophycin which may act to store excess nitrogen YP_725291.1 6 TMHs YP_725296.1 REC (residues 4 to 118, 6e-21) with a complete phosphorylation pocket (DD-D50-S82-K111) YP_725298.1 4 TMHs YP_725302.1 Involved in ubiquinone biosynthesis YP_725304.1 negatively supercoils closed circular double-stranded DNA YP_725306.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine YP_725308.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_725310.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_725312.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_725313.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_725314.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_725318.1 corresponds todomain I of RfaE from E. coli, involved in LPS biosynthesis YP_725319.1 involved in LPS biosynthesis YP_725321.1 11 TMHs YP_725322.1 catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide YP_725325.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_725326.1 part of the metNIQ transport system for methionine YP_725327.1 5 TMHs YP_725332.1 catalyzes the oxidative deamination of D-amino acids YP_725342.1 REC (residues 12 to 125, 3e-19) with a complete phosphorylation pocket (DD-D56-T78-K97) YP_725351.1 12 TMHs YP_725362.1 6 TMHs YP_725373.1 12 TMHs YP_725377.1 Acyl-CoA dehydrogenase (EC 1.3.99.-) YP_725399.1 chain a intracellular ser/thr protein kinase domain YP_725408.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_725409.1 Essential for efficient processing of 16S rRNA YP_725410.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_725411.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_725414.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase YP_725418.1 6 TMHs YP_725424.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_725425.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_725427.1 catalyzes the formation of deamido-NAD(+) from nicotinate ribonucleotide and ATP YP_725428.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis YP_725429.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_725432.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_725433.1 12 TMHs YP_725444.1 9 TMHs YP_725446.1 catalyzes the formation of methylglyoxal from glycerone phosphate YP_725450.1 9 TMHs YP_725451.1 10 TMHs YP_725454.1 6 TMHs YP_725456.1 5 TMHs YP_725460.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_725461.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine YP_725462.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_725466.1 Essential for recycling GMP and indirectly, cGMP YP_725467.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_725469.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_725509.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate YP_725512.1 NAD-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; does not decarboxylate oxaloacetate YP_725517.1 11 TMHs YP_725522.1 DesA YP_725523.1 Catalyzes the deamination of guanine YP_725524.1 catalyzes the formation of inosine from adenosine YP_725532.1 10 TMHs YP_725541.1 4 TMHs YP_725544.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates YP_725545.1 acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate YP_725546.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit YP_725547.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_725548.1 catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine YP_725551.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis YP_725554.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_725557.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_725559.1 Catalyzes the transfer of electrons from NADH to quinone YP_725560.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen YP_725561.1 Catalyzes the transfer of electrons from NADH to quinone YP_725562.1 Catalyzes the transfer of electrons from NADH to quinone YP_725563.1 Catalyzes the transfer of electrons from NADH to quinone YP_725565.1 Catalyzes the transfer of electrons from NADH to ubiquinone YP_725566.1 Catalyzes the transfer of electrons from NADH to quinone YP_725567.1 Catalyzes the transfer of electrons from NADH to quinone YP_725568.1 Catalyzes the transfer of electrons from NADH to quinone YP_725569.1 Catalyzes the transfer of electrons from NADH to quinone YP_725570.1 Catalyzes the transfer of electrons from NADH to ubiquinone YP_725571.1 Catalyzes the transfer of electrons from NADH to quinone YP_725572.1 Catalyzes the transfer of electrons from NADH to quinone YP_725585.1 8 TMHs YP_725586.1 9 TMHs YP_725590.1 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter YP_725591.1 6 TMHs YP_725592.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) is involved with urease activity, optimum growth, resistance to low-pH killing in-vitro and persistence in-vivo, while the other operon does not seem to be active YP_725593.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits YP_725594.1 involved in the assembly of the urease metallocenter; possible nickel donor YP_725610.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_725611.1 converts 3-hydroxyadipyl-CoA to beta-ketoadipyl-CoA in phenylacetate degradation YP_725613.1 catalyzes the transfer of an amino moiety YP_725622.1 catalyzes the formation of benzaldehyde from benzoylformate YP_725631.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive YP_725632.1 unknown EC_number=2.1.1.- YP_725636.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme YP_725641.1 catalyzes the phosphorylation of NAD to NADP YP_725642.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons YP_725643.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_725646.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor YP_725650.1 10 TMHs YP_725653.1 Predicted hydrolases or acyltransferases YP_725657.1 Involved in the electron transport chain YP_725660.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_725661.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_725665.1 6 TMHs YP_725667.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis YP_725671.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins YP_725672.1 involved in the maturation of iron-sulfur cluster-containing proteins YP_725676.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_725677.1 FabG YP_725682.1 4 TMHs YP_725687.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate YP_725694.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_725695.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis YP_725697.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_725698.1 forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein YP_725703.1 12 TMHs YP_725711.1 5 TMHs YP_725712.1 unknown EC_number=2.1.1.- YP_725713.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_725719.1 This protein performs the mismatch recognition step during the DNA repair process YP_725724.1 unknown EC_number=2.1.1.- YP_725725.1 CysE YP_725726.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine YP_725730.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_725731.1 ENDO3c YP_725732.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein YP_725734.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation. YP_725744.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_725745.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_725749.1 7 TMHs YP_725750.1 8 TMHs YP_725759.1 biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate YP_725761.1 6 TMHs YP_725763.1 catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates YP_725773.1 3 TMHs YP_725774.1 8 TMHs YP_725791.1 12 TMHs YP_725803.1 activates fatty acids by binding to coenzyme A YP_725805.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_725809.1 6 TMHs YP_725810.1 4 TMHs YP_725818.1 6 TMHs YP_725819.1 2 TMHs YP_725821.1 catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol YP_725823.1 11 TMHs YP_725825.2 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_725826.1 10 TMHs YP_725831.1 acts as a molecular chaperone to fold and export lipase A YP_725834.1 4 TMHs YP_725835.1 13 TMHs YP_725842.1 catalyzes the formation of acetoacetate from 3-hydroxybutyrate YP_725846.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_725849.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_725850.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_725851.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_725852.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_725868.1 catalyzes the transformation of hydroxyatrazine to N-isopropylammelide and ethylamine in the atrazine degradation pathway. YP_725870.1 10 TMHs YP_725874.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_725876.1 REC (residues 15 to 127, 4e-24) with a complete phosphorylation pocket (DD-D48-T86-K96) YP_725877.1 2 TMHs YP_725878.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC YP_725885.1 Phasin (PHA-granule associated protein) YP_725887.1 10 TMHs YP_725898.1 mu-crystallin homolog YP_725902.1 8 TMHs YP_725905.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_725906.1 Conjugates Arg from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate YP_725907.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys YP_725913.1 cleaves the ring of 2,3-dihydro-2,3-dihydroxybenzoyl-CoA forming 6-hydroxy-3-hexenoyl-CoA YP_725914.1 consists of N-terminal helix-turn-helix domain and C-terminal shikimate kinase-like domain which may bind benzoyl-CoA; controls inducible expression of the bzd catabolic operon that is involved in the anaerobic catabolism of benzoate YP_725918.1 6 TMHs YP_725919.1 8 TMHs YP_725922.1 12 TMHs YP_725929.1 11 TMHs YP_725930.1 REC (residues 3 to 114, 1e-23) with a typical phosphorylation pocket (1/2 DD,D54,S/T82,K105) YP_725941.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis YP_725942.1 catalyzes the formation of 3-hydroxybutyryl-CoA from acetoacetyl-CoA in polyhydroxyalkanoate synthesis YP_725947.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit YP_725948.1 catalyzes the formation of beta-ketovaleryl-CoA from acetyl-CoA and propionyl-CoA YP_725950.1 catalyzes the formation of L-homocysteine from cystathionine YP_725957.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine YP_725959.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers YP_725960.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate YP_725964.1 12 TMHs YP_725965.1 2 TMHs YP_725966.1 part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation YP_725968.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide YP_725971.1 12 TMHs YP_725972.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia YP_725975.1 5 TMHs YP_725976.1 6 TMHs YP_725983.1 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules YP_725984.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_725985.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_725986.1 binds and unfolds substrates as part of the ClpXP protease YP_725995.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_726002.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_726003.1 10 TMHs YP_726006.1 11 TMHs YP_726009.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia YP_726011.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_726016.1 Involved in cell division; probably involved in intracellular septation YP_726017.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress YP_726019.1 activates fatty acids by binding to coenzyme A YP_726021.1 7 TMHs YP_726022.1 11 TMHs YP_726025.1 12 TMHs YP_726028.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_726031.1 Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate YP_726036.1 probable dehydrogenase YP_726040.1 8 TMHs YP_726041.1 8 TMHs YP_726049.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_726059.1 12 TMHs YP_726069.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_726070.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_726088.1 5 TMHs YP_726103.1 13 TMHs YP_726108.1 2 TMHs YP_726110.1 11 TMHs YP_726115.1 7 TMHs YP_726129.1 12 TMHs YP_726140.1 2 TMHs YP_726141.1 5 TMHs YP_726142.1 14 TMHs YP_726143.1 2 TMHs YP_726151.1 Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C YP_726154.1 4 TMHs YP_726177.1 11 TMHs YP_726187.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_726189.1 unknown EC_number 1.6.8.- YP_726208.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_726210.1 activates fatty acids by binding to coenzyme A YP_726220.1 11 TMHs YP_726222.1 2 TMHs YP_726223.1 Hypothetical Membrane Associated Protein YP_726225.1 12 TMHs YP_726229.1 12 TMHs YP_726232.1 12 TMHs YP_726238.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC YP_726240.1 REC (residues 8 to 121, 6e-25) with a complete phosphorylation pocket (DD-D55-T82-K97) YP_726242.1 5 TMHs YP_726250.1 11 TMHs YP_726280.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate YP_726289.1 Hypothetical Membrane Spanning Protein YP_726290.1 REC (residues 5 to 117, 5e-26) with a complete phosphorylation pocket (DD-D55-T96-K108) YP_726331.1 Glycosyl transferases group 1 YP_726344.1 unknown EC_number=2.1.1.- YP_726345.1 subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport YP_726346.1 subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport YP_726347.1 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport YP_726348.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone YP_726349.1 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_726350.1 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved with K+ YP_726354.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_726356.1 Thiolase YP_726358.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_726360.1 10 TMHs YP_726361.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis YP_726362.1 5 TMHs YP_726366.1 12 TMHs YP_726372.1 CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis YP_726374.1 catalyzes the formation of pyruvate and succinate from 2-methylisocitrate YP_726375.1 catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity YP_726376.1 Catalyzes the conversion of citrate to isocitrate YP_726378.1 functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C YP_726386.1 Catalyzes the transfer of the ammonia group from glutamine to a new carbon-nitrogen group YP_726391.1 catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine YP_726408.1 16 TMHs YP_726418.1 MDM; functions in conversion of succinate to propionate YP_726429.1 catalyzes the degradation of 2-hydro-1,2-dihydroxy benzoate to catechol YP_726440.1 activates fatty acids by binding to coenzyme A YP_726444.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP YP_726445.1 8 TMHs YP_726454.1 2 TMHs YP_726455.1 5 TMHs YP_726478.1 2 TMHs YP_726480.1 catalyzes the formation of thymine and 2-deoxy-alpha-D-ribose 1-phosphate from thymidine YP_726487.1 REC (residues 34 to 126, 4e-04) with an incomplete phosphorylation pocket (only D54,S/T82) YP_726488.1 REC (residues 4 to 118, 2e-21) with a complete phosphorylation pocket (DD-D50-T77-K98) YP_726491.1 8 TMHs YP_726495.1 10 TMHs YP_726496.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_726498.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_726503.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_726506.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_726509.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_726510.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM YP_726511.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis YP_726512.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_726513.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis YP_726516.1 2 TMHs YP_726517.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_726520.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_726521.1 Catalyzes the phosphorylation of UMP to UDP YP_726522.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_726523.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_726524.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_726525.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein YP_726527.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_726532.1 10 TMHs YP_726533.1 catalyzes the formation of succinyldiaminopimelate from N-succinyl-2-amino-6-ketopimelate YP_726534.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway YP_726535.1 1 TMHs YP_726537.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_726538.1 involved in methylation of ribosomal protein L3 YP_726550.1 6 TMHs YP_726551.1 5 TMHs YP_726553.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia YP_726558.1 8 TMHs YP_726559.1 unknown EC_number=2.1.1.- YP_726565.1 6 TMHs YP_726566.1 6 TMHs YP_726573.1 undetermined role; similar to CarB protein but much smaller YP_726577.1 disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein YP_726579.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_726580.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer YP_726581.1 11 TMHs YP_726587.1 14 TMHs YP_726594.1 metal-dependent hydrolase mm2300 YP_726600.1 REC (residues 14 to 127, 2e-18) with a complete phosphorylation pocket (DD-D59-T81-K97) YP_726629.1 1 TMHs YP_726630.1 12 TMHs YP_726632.1 REC (residues 3 to 113, 4e-24) with a typical phosphorylation pocket (1/2 DD,D54,S/T82,K105) YP_726635.1 5 TMHs YP_726638.1 8 TMHs YP_726641.1 10 TMHs YP_726648.1 unknown EC_number=3.1.3.1- YP_726651.1 1 TMHs YP_726652.1 11 TMHs YP_726664.1 12 TMHs YP_726676.1 Catalyzes the first step in the glyoxalate cycle, which converts lipids to carbohydrates YP_726681.1 unknown EC_number=2.1.1.- YP_726682.1 Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle YP_726695.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity YP_726696.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; also known as acetolactate synthase large subunit YP_726698.1 REC (residues 5 to 117, 2e-17) with a complete phosphorylation pocket (DD-D51-T78-K97) YP_726699.1 4 TMHs YP_726703.1 6 TMHs YP_726704.1 7 TMHs YP_726708.1 6 TMHs YP_726709.1 catalyzes the release of sulfite from alkanesulfonates YP_726718.1 7 TMHs YP_726719.1 8 TMHs YP_726723.1 enoyl-coa hydratase/isomerase family protein YP_726726.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling YP_726730.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_726731.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine YP_726732.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor YP_726738.1 8 TMHs YP_726740.1 unwinds double stranded DNA YP_726741.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_726742.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_726744.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_726746.1 Represses a number of genes involved in the response to DNA damage YP_726755.1 catalyzes the formation of 3-hydroxy-2-methylpropanoate from 3-hydroxy-2-methylpropanoyl-CoA YP_726764.1 alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family YP_726768.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_726769.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_726770.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_726771.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_726772.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_726779.1 5 TMHs YP_726780.1 2 TMHs YP_726782.1 CcoO; FixO YP_726783.1 CcoN; FixN YP_726785.1 9 TMHs YP_726787.1 E3 component of 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_726788.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA YP_726789.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_726790.1 hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate YP_726791.1 part of the UgpABCE glycerol-3-phosphate uptake system YP_726792.1 6 TMHs YP_726793.1 6 TMHs YP_726796.1 REC (residues 5 to 116, 3e-24) with a complete phosphorylation pocket (DD-D57-S81-K101) YP_726807.1 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis YP_726809.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway YP_726812.1 unknown EC_number=2.1.1.- YP_726817.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_726818.1 May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine YP_726822.1 Stimulates the elongation of poly(A) tails YP_726823.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_726826.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_726827.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_726831.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_726832.1 7 TMHs YP_726833.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S] YP_726836.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses YP_726839.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate YP_726842.1 REC (residues 3 to 115, 2e-25) with a typical phosphorylation pocket (1/2 DD,D54,S/T82,K105) YP_726844.1 5 TMHs YP_726852.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA YP_726858.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_726860.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_726861.1 12 TMHs YP_726863.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_726867.1 4 TMHs YP_726868.1 6 TMHs YP_726870.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_726871.1 12 TMHs YP_726874.1 2 TMHs YP_726875.1 10 TMHs YP_726878.1 8 TMHs YP_726886.1 5 TMHs YP_726888.1 4 TMHs YP_726890.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_726894.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate YP_726896.1 REC (residues 5 to 119, 2e-26) with a typical phosphorylation pocket (1/2 DD,D54,S/T82,K105) YP_726898.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_726899.1 Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions YP_726900.1 part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions YP_726902.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_726904.1 2 TMHs YP_726905.1 unknown EC_number=2.1.1.- YP_726907.1 4 TMHs YP_726908.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_726909.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_726911.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_726916.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_726918.1 catalyzes the conversion of salicylyl-CoA to gentisyl-CoA YP_726919.1 catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent YP_726922.1 unknown EC_number=2.1.1.- YP_726923.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids YP_726924.1 3'-5' exonuclease of DNA polymerase III YP_726955.1 3 TMHs YP_726956.1 6 TMHs YP_726957.1 6 TMHs YP_726961.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine YP_726979.1 14 TMHs YP_726980.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA YP_726984.1 converts L-glutamate to D-glutamate, a component of peptidoglycan YP_726988.1 3 TMHs YP_726994.1 8 TMHs YP_726996.1 11 TMHs YP_726998.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_727000.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_727001.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides YP_727002.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_727003.1 involved in the de novo synthesis of pyridoxine (Vitamin B6) YP_727004.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA YP_727005.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_727006.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_727009.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_727010.1 Thioredoxin-like protein (SSF52833) YP_727014.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response YP_727015.1 2 TMHs YP_727016.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_727017.1 carries the fatty acid chain in fatty acid biosynthesis YP_727018.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_727020.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_727021.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_727022.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_727024.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_727025.1 unknown EC_number=2.1.1.- YP_727032.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z YP_727033.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis YP_727035.1 2 TMHs YP_727038.1 12 TMHs YP_727040.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate YP_727049.1 REC (residues 9 to 119, 3e-24) with a typical phosphorylation pocket (1/2 DD,D54,S/T82,K105) YP_727050.1 3 TMHs YP_727051.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_727052.1 involved in the export of lipooligosaccharides during nodulation YP_727053.1 6 TMHs YP_727054.1 4 TMHs YP_727056.1 catalyzes the conversion of O-succinylhomoserine into homocysteine YP_727057.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_727058.1 4 TMHs YP_727061.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits YP_727062.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_727064.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_727065.1 catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis YP_727066.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_727068.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_727069.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_727070.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_727071.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_727073.1 Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_727074.1 Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_727075.1 8 TMHs YP_727077.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH YP_727079.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase YP_727080.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_727084.1 catalyzes the oxidation of malate to oxaloacetate YP_727086.1 catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity YP_727088.1 catalyzes the conversion of citrate to isocitrate YP_727091.1 unknown EC_number=2.1.1.- YP_727094.1 2 TMHs YP_727102.1 molecular chaperone YP_727106.1 5 TMHs YP_727112.1 6 TMHs YP_727114.1 5 TMHs YP_727115.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_727117.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_727118.1 12 TMHs YP_727120.1 10 TMHs YP_727122.1 4 TMHs YP_727131.1 7 TMHs YP_727141.1 deleted EC_number 2.7.1.37 YP_727149.1 5 TMHs YP_727150.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_727154.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis YP_727155.1 8 TMHs YP_727156.1 3'-5' exoribonuclease specific for small oligoribonuclotides YP_727158.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity YP_727160.1 catalyzes the formation of adenosylcobinamide-phosphate from adenosylcobyric acid YP_727163.1 this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu YP_727172.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria YP_727173.1 synthesizes RNA primers at the replication forks YP_727177.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_727178.1 similar protein in Methanocaldococcus converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate as the first step in methanopterin biosynthesis YP_727179.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_727181.1 catalyzes the bidirectional exonucleolytic cleavage of DNA YP_727183.1 10 TMHs YP_727185.1 6 TMHs YP_727188.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_727191.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine YP_727196.1 10 TMHs YP_727198.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_727201.1 5 TMHs YP_727202.1 5 TMHs YP_727210.1 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown YP_727212.1 12 TMHs YP_727214.1 5 TMHs YP_727216.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_727218.1 3 TMHs YP_727220.1 11 TMHs YP_727221.1 4 TMHs YP_727231.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_727241.1 activates fatty acids by binding to coenzyme A YP_727248.1 9 TMHs YP_727249.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate YP_727252.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress YP_727269.1 2 TMHs YP_727270.1 9 TMHs YP_727274.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA YP_727277.1 3 TMHs YP_727279.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_727294.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_727299.2 bifunctional enzyme DHBP synthase/GTP cyclohydrolase II-like protein; functions in riboflavin synthesis YP_727300.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_727301.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_727305.1 AcsA; in Sinorhizobium meliloti this enzyme is required for acetoacetate activation; similar to acetyl-CoA synthase YP_727314.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_727315.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_727320.1 10 TMHs YP_727325.1 12 TMHs YP_727327.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A YP_727330.1 4 TMHs YP_727332.1 12 TMHs YP_727334.1 11 TMHs YP_727336.1 8 TMHs YP_727338.1 2 TMHs YP_727348.1 6 TMHs YP_727354.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP YP_727356.1 Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides YP_727357.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_727358.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity YP_727359.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_727363.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane and the formation of precorrin-2 from uroporphyrin III and S-adenosyl-L-methionine by two sequential methylation reactions; functions in tetrapyrrole and heme biosynthesis YP_727364.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_727365.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate YP_727369.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_727370.1 4 TMHs YP_727371.1 12 TMHs YP_727375.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis YP_727378.1 5 TMHs YP_727380.1 HybA YP_727389.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_727391.1 activates fatty acids by binding to coenzyme A YP_727394.1 6 TMHs YP_727395.1 5 TMHs YP_727403.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_727404.1 4 TMHs YP_727405.1 catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation YP_727407.1 CobD; CbiD in Salmonella; converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group YP_727408.1 cobalamin biosynthesis protein; decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin; structurally similar to histidinol phosphate aminotransferase YP_727411.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole YP_727412.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole YP_727415.1 8 TMHs YP_727420.1 8 TMHs YP_727422.1 catalyzes the formation of malonyl-CoA from malonate and CoA YP_727429.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_727431.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_727433.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB YP_727434.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_727435.1 6 TMHs YP_727436.1 6 TMHs YP_727438.1 catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1 YP_727440.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP YP_727441.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite YP_727444.1 8 TMHs YP_727446.1 unknown EC_number=2.1.1.- YP_727451.1 9 TMHs YP_727452.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_727453.1 5 TMHs YP_727454.1 12 TMHs YP_727457.1 catalyzes the deimination of N-formimino-L-glutamate to ammonia and N-formyl-L-glutamate YP_727458.1 catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway YP_727460.1 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism YP_727461.1 catalyzes the degradation of histidine to urocanate and ammmonia YP_727464.1 6 TMHs YP_727467.1 catalyzes the formation of 3,6-dideoxy-D-glycero-D-glycero-4-hexulose YP_727468.1 DapATase; functions in arginine biosynthetic pathway; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine YP_727471.1 8 TMHs YP_727472.1 7 TMHs YP_727474.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_727476.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase YP_727477.1 required for 70S ribosome assembly YP_727478.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_727479.1 catalyzes the formation of oxaloacetate from L-aspartate YP_727480.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide YP_727481.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate YP_727483.1 6 TMHs YP_727485.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate YP_727486.1 REC (residues 8 to 123, 8e-14) with a complete phosphorylation pocket (DD-D61-S93-K112) YP_727487.1 5 TMHs YP_727488.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities YP_727489.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme YP_727490.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_727491.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine YP_727496.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA YP_727499.1 Converts isocitrate to alpha ketoglutarate YP_727503.1 nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription YP_727504.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_727506.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation YP_727508.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_727512.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_727513.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_727518.1 catalyzes the hydrolytic cleavage of imides that range from linear to heterocyclic and that include hydantoins, dihydropyrimidines, and phthalimides YP_727519.1 12 TMHs YP_727520.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_727521.1 6 TMHs YP_727527.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_727531.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_727532.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_727538.1 6 TMHs YP_727541.1 2 TMHs YP_727542.1 5 TMHs YP_727549.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate YP_727550.1 catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway YP_727554.1 catalyzes branch migration in Holliday junction intermediates YP_727555.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_727556.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_727557.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex YP_727558.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_727559.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_727561.1 REC (residues 11 to 125, 3e-14) with a complete phosphorylation pocket (DD-D56-T87-K98) YP_727562.1 5 TMHs YP_727563.1 unknown EC_number=2.1.1.- YP_727566.1 4 TMHs YP_727567.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_727569.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_727572.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) YP_727573.1 3 TMHs YP_727574.1 11 TMHs YP_727575.1 REC (residues103 to 159, 2e-06) with an incomplete phosphorylation pocket (only 1/2 DD,D54) YP_727576.1 unknown EC_number=2.1.1.- YP_727579.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_727580.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA YP_727584.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_727590.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_727592.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_727596.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate YP_727597.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP YP_727598.1 4 TMHs YP_727600.1 type 2 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase YP_727601.1 10 TMHs YP_727602.1 2 TMHs YP_727603.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan YP_727604.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_727613.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis YP_727614.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_727615.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_727616.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype YP_727628.1 9 TMHs YP_727632.1 Required for efficient pilin antigenic variation YP_727644.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_727668.1 6 TMHs YP_727677.1 Catalyzes the rate-limiting step in dNTP synthesis YP_727678.1 Catalyzes the rate-limiting step in dNTP synthesis YP_727680.1 REC (residues 26 to 138, 4e-21) with a complete phosphorylation pocket (DD-D53-S79-K96) YP_727681.1 5 TMHs YP_727683.1 9 TMHs YP_727685.1 Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively YP_727686.1 4 TMHs YP_727689.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_727690.1 hydrolyzes diadenosine polyphosphate YP_727692.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_727693.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_727694.1 involved in the peptidyltransferase reaction during translation YP_727699.1 6 TMHs YP_727700.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_727705.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate YP_727706.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_727708.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis YP_727710.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_727713.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_727714.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_727715.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_727716.1 10 TMHs YP_727717.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_727718.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_727720.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_727724.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_727729.1 signal peptide YP_727730.1 activates fatty acids by binding to coenzyme A YP_727738.1 5 TMHs YP_727739.1 5 TMHs YP_727744.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_727746.1 4 TMHs YP_727748.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_727753.1 protein associated with Co2+ and Mg2+ efflux YP_727754.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate YP_727756.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine YP_727757.1 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity YP_727758.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate YP_727759.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water YP_727761.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_727762.1 catalyzes the hydrolysis of acylphosphate YP_727763.1 12 TMHs YP_727765.1 6 TMHs YP_727770.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_727772.1 11 TMHs YP_727773.1 9 TMHs YP_727774.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine YP_727776.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins YP_727777.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_727779.1 unknown EC_number=2.1.1.- YP_727781.1 catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate YP_727788.1 activates fatty acids by binding to coenzyme A YP_727793.1 12 TMHs YP_727795.1 signal peptide YP_727797.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_727798.1 C-terminal Hexahistidin YP_727804.1 12 TMHs YP_727809.1 catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate YP_727816.1 13 TMHs YP_727823.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia YP_727825.1 2 TMHs YP_727826.1 REC (residues 5 to 114, 1e-16) with a complete phosphorylation pocket (DD-D51-T75-K94) YP_727827.1 2 TMHs YP_727833.1 12 TMHs YP_727835.1 homopentamer; channel that opens in response to pressure or hypoosmotic shock YP_727839.1 6 TMHs YP_727841.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes YP_727843.1 3 TMHs YP_727844.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis YP_727845.1 PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers YP_727846.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_727847.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_727848.2 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_727849.1 6 TMHs YP_727850.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis YP_727851.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_727852.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_727853.1 short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ YP_727854.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_727856.1 7 TMHs YP_727862.1 5 TMHs YP_727866.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate YP_727869.1 dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate YP_727870.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_727871.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_727878.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly YP_727880.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme YP_727881.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ YP_727886.1 4 TMHs YP_727888.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_727889.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_727890.1 2 TMHs YP_727891.1 8 TMHs YP_727893.1 is a component of the macrolide binding site in the peptidyl transferase center YP_727894.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_727895.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_727896.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_727897.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_727898.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif YP_727899.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_727900.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_727901.1 late assembly protein YP_727902.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_727903.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_727904.1 binds 5S rRNA along with protein L5 and L25 YP_727905.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_727906.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_727907.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_727908.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_727909.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_727910.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_727911.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_727912.1 one of the stabilizing components for the large ribosomal subunit YP_727913.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_727914.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_727915.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_727916.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_727917.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_727918.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_727919.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_727920.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_727926.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_727927.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_727928.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_727929.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_727930.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_727932.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_727933.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_727934.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_727935.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_727936.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_727937.1 binds directly to 23S ribosomal RNA YP_727938.1 Modulates Rho-dependent transcription termination YP_727939.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_727940.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_727941.1 activates fatty acids by binding to coenzyme A YP_727943.1 9 TMHs YP_727944.1 9 TMHs YP_727947.1 with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA YP_727948.1 with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA; involved in phenylacetate degradation YP_727954.1 transport system that facilitates potassium-efflux YP_727962.1 pseudopilin PulG/GspG YP_727974.1 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates YP_727978.1 Glyoxlase YP_727986.1 4 TMHs YP_728004.1 involved in LPS biosynthesis YP_728006.1 unknown EC_number=2.1.1.- YP_728010.1 transmembrane YP_728015.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide YP_728016.1 involved in the transport of C4-dicarboxylates across the membrane YP_728020.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_728024.1 catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate YP_728030.1 12 TMHs YP_728035.1 metalloprotease YP_728040.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_728044.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein YP_728045.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor YP_728046.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine YP_728052.1 ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity YP_728053.1 11 TMHs YP_728056.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein YP_728057.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity YP_728058.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_728061.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_728062.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_728063.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_728064.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_728065.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_728066.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. YP_728067.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_728068.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_728069.1 4 TMHs YP_728072.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_728073.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_728078.1 9 TMHs YP_728079.1 9 TMHs YP_728081.1 7 TMHs YP_728083.1 8 TMHs YP_728084.1 8 TMHs YP_728088.1 BetA YP_728093.1 7 TMHs YP_728098.1 catalyzes the formation of L-proline from L-ornithine YP_728100.1 6 TMHs YP_728103.1 phenylalanine 4-hydroxylase; phenylalanine 4-hydroxylase; catalyzes the formation of 4a-hydroxytetrahydrobiopterin and tyrosine from phenylalanine and tetrahydrobiopterin YP_728104.1 4-alpha-hydroxytetrahydrobiopterin dehydratase activity; catalyzes the formation of (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7, 8-dihydro-6H-pterin from (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7, 8-tetrahydro-4a-hydroxypterin; functions in recycling tetrahydrobiopterin (BH4) in phenylalanine hydroxylase reaction YP_728105.1 REC (residues 3 to 115, 2e-22) with a complete phosphorylation pocket (DD-D55-S85-K96) YP_728111.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_728112.1 10 TMHs YP_728115.1 6 TMHs YP_728116.1 6 TMHs YP_728118.1 REC (residues 4 to 117, 2e-23) with a complete phosphorylation pocket (DD-D55-T88-K103) YP_728119.1 4 TMHs YP_728123.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth YP_728124.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_728128.1 decatenates replicating daughter chromosomes YP_728130.1 transmembrane YP_728132.1 15 TMHs YP_728134.1 REC (residues 14 to 132, 9e-18) with a complete phosphorylation pocket (DD-D54-S81-K102) YP_728135.1 catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using GTP YP_728137.1 10 TMHs YP_728139.1 1 TMHs YP_728140.1 10 TMHs YP_728143.1 signal peptide; transmembrane YP_728145.1 5 TMHs YP_728150.1 REC (residues 3 to 115, 4e-24) with a typical phosphorylation pocket (1/2 DD,D54,S/T82,K105) YP_728154.1 12 TMHs YP_728159.1 GIT YP_728168.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_728171.1 in Escherichia coli transcription of this gene is enhanced by polyamines YP_728176.1 HisKA YP_728184.1 Involved in the biosynthetic pathways of fatty acids, phospholipids, lipopolysaccharides, and oligosaccharides YP_728211.1 4 TMHs YP_728214.1 signal peptide YP_728217.1 catalyzes the reaction of cyanate and bicarbonate to produce ammonia and carbon dioxide YP_728218.1 12 TMHs; MFS transporter, cyanate permease family YP_728223.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis YP_728226.1 signal peptide YP_728231.1 2 TMHs YP_728233.1 Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate YP_728241.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile YP_728244.1 ABC-type transporter, ATPase component YP_728246.1 9 TMHs YP_728247.1 7 TMHs YP_728261.1 13 TMHs YP_728266.1 8 TMHs YP_728268.1 catalyzes the formation of acetaldehyde from ethanolamine YP_728272.1 member of a large family of NAD or NADP-dependent oxidoreductases; paralogs occur in many bacteria YP_728274.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_728279.1 1 TMHs YP_728281.1 12 TMHs YP_728284.1 10 TMHs YP_728288.1 2 TMHs YP_728289.1 8 TMHs YP_728290.1 3 TMHs YP_728295.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_728302.1 catalyzes the formation of 2,5-dioxopentanoate from 5-dehydro-4-deoxy-D-glucarate YP_728306.1 alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family YP_728308.1 14 TMHs YP_728340.1 activates fatty acids by binding to coenzyme A YP_728366.1 catalyzes the thiolytic cleavage of beta-ketoadipyl-CoA to succinate and acetyl-CoA YP_728370.1 catalyzes the oxidation of tricarballylate to cis-aconitate; FAD-dependent; required for the utilization of tricarballylate as a carbon and energy source by S. enterica YP_728382.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) YP_728395.1 3 TMHs YP_728401.1 with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems YP_728402.1 With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems YP_728403.1 4 TMHs YP_728404.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_728407.1 MeTrc YP_728408.1 catalyzes the conversion of glutamine residues to glutamate on methyl-accepting chemotaxis receptors YP_728409.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins YP_728411.1 cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation YP_728418.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export YP_728419.1 membrane protein involved in the flagellar export apparatus YP_728420.1 positive regulator of class III flagellar genes YP_728425.1 negative regulator of flagellin synthesis,anti-sigma factor YP_728426.1 required for the assembly of the flagellar basal body P-ring YP_728427.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella YP_728429.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production YP_728430.1 the hook connects flagellar basal body to the flagellar filament YP_728431.1 FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod YP_728432.1 makes up the distal portion of the flagellar basal body rod YP_728433.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Burkholderia thailandensis has 2 copies of this and other flagella genes YP_728434.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum YP_728435.1 Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space YP_728436.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook YP_728437.1 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes. YP_728446.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_728454.1 14 TMHs YP_728456.1 6 TMHs YP_728457.1 5 TMHs YP_728468.1 10 transmembrane helices (TMpred) YP_728476.1 5 TMHs YP_728482.1 transports degraded pectin products into the bacterial cell YP_728484.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) YP_728488.1 12 TMHs YP_728502.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis YP_728506.1 12 TMHs YP_728553.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_728570.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_728573.1 h16_B0409; Non-functional due to fragmentation: Partial acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II YP_728574.1 signal peptide YP_728583.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_728593.1 12 TMHs YP_728594.1 several (7) TM helices (TMpred) YP_728602.1 10 TMHs YP_728603.1 2 TMHs YP_728604.1 4 TMHs YP_728607.1 Non-functional due to fragmentation: site-specific recombinase YP_728608.1 Non-functional due to fragmentation: site-specific recombinase YP_728610.1 3TMHs YP_728615.1 6 TMHs YP_728616.1 6 TMHs YP_728621.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine YP_728639.1 5 TMHs YP_728652.1 12 transmembrane helices predicted (TMpred) YP_728665.1 8 TMHs YP_728666.1 8 TMHs YP_728670.1 catalyzes the oxidative deamination of D-amino acids YP_728713.1 catalyzes the formation of acetyl-CoA from acetalaldehyde YP_728714.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate YP_728716.1 catalyzes the formation of 2-oxobutanoate from L-threonine or the formation of pyruvate from serine YP_728720.1 catalyzes the formation of thymine and 2-deoxy-alpha-D-ribose 1-phosphate from thymidine YP_728724.1 with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus YP_728725.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus YP_728730.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate YP_728735.1 about 8 transmembrane helices(TMpred) YP_728745.1 10 TMHs YP_728748.1 7 TMHs YP_728751.1 thiamine-pyrophosphate requiring enzyme YP_728757.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate YP_728758.1 catalyzes the formation of acetyl-CoA from acetalaldehyde YP_728784.1 7 TMHs YP_728788.1 in Rhizobium meliloti this protein is involved in the synthesis of nodulation factors that are active on the roots of alfalfa; catalyzes formation of activated sulfate intermediate; converts ATP and sulfate to diphosphate and adenylylsulfate and then ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; the activated intermediate is transferred to the nodulation factors by NodH; may interact with NodP and NodQ; similar to the CysD and CysN proteins from EScherichia coli involved in cysteine biosynthesis YP_728789.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP YP_728806.1 activates fatty acids by binding to coenzyme A YP_728819.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_728821.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_728824.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_728852.1 6 TMHs YP_728858.1 activates fatty acids by binding to coenzyme A YP_728874.1 11 TMHs YP_728876.1 activates fatty acids by binding to coenzyme A YP_728881.1 5 TMHs YP_728882.1 6 TMHs YP_728885.1 10 or 11 transmembrane helices (TMpred) YP_728893.1 member of a large family of NAD or NADP-dependent oxidoreductases; paralogs occur in many bacteria YP_728898.1 catalyzes the formation of L-aspartate to iminoaspartate in NAD(+) biosynthesis YP_728902.1 12 TMHs YP_728915.1 activates fatty acids by binding to coenzyme A YP_728918.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_728921.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_728924.1 5 transmembrane helices (TMpred) YP_728931.1 12 TMHs YP_728937.1 12 TMHs YP_728943.1 TMpred: 8 strong transmembrane helices,total score : 14709 YP_728948.1 12 TMHs YP_728949.1 14 TMHs YP_728950.1 3 TMHs YP_728961.1 8 TMHs YP_728962.1 8 TMHs YP_728966.1 11 TMHs YP_728976.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine YP_728981.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_728986.1 6 transmembrane helices (TMpred) YP_728989.1 12 TMHs YP_728991.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA YP_728992.1 9 TMHs YP_729018.1 12 TMHs YP_729024.1 13 TMHs YP_729027.1 6 TMHs YP_729033.1 catalyzes the formation of catechol from salicylate YP_729034.1 10 TMHs YP_729037.1 3 TMHs YP_729038.1 12 TMHs YP_729047.1 6 TMHs YP_729050.1 signal peptide YP_729051.1 response regulator, OmpR-family YP_729052.1 3 TMHs YP_729054.1 7 TMHs YP_729055.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_729056.1 8 transmembrane helices (TMpred) YP_729057.1 transcriptional regulator, TetR/AcrR-family YP_729074.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA YP_729076.1 with FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems YP_729088.1 6 TMHs YP_729096.1 8 or 9 transmembrane helices (TMpred) YP_729106.1 possibly membrane-associated (one N-terminal tm-helix [TMpred]) YP_729109.1 6 TMHs YP_729110.1 6 TMHs YP_729112.1 15 TMHs YP_729114.1 1 TMHs YP_729117.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_729123.1 transcriptional regulator, LysR-family YP_729127.1 catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate YP_729133.1 11 TMHs YP_729134.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions YP_729138.1 MEDLINE: 20033526 YP_729143.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_729148.1 12 TMHs YP_729152.1 12 TMHs YP_729155.1 6 transmembrane helices YP_729158.1 transcriptional regulator, AraC-family YP_729168.1 12 TMHs YP_729175.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate YP_729181.1 bo3-type chinol oxidase, subunit II YP_729185.1 signal peptide YP_729191.1 transcriptional regulator, AraC-family YP_729194.1 1 TMHs YP_729198.1 PQQ binding motif YP_729199.1 signal peptide YP_729200.1 ABC-type multidrug transport system, permease component YP_729201.1 signal peptide YP_840568.1 PQQ YP_840570.1 Elp3 YP_840571.1 part of cluster PqqBCDE YP_840572.1 Required in the synthesis of PPQ, but its exact function is unknown YP_840573.1 possibly involved in transport of pyrroloquinoline quinone transport YP_840583.1 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis. It is not the major replicative DNA polymerase. YP_840587.1 transcriptional regulator, GlvR-family YP_840591.1 1 TMHs YP_840592.1 8 transmembrane helices (TMpred) YP_840595.1 2 TMHs YP_840597.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive YP_840601.1 ly similar to CoxL/CutU homologs YP_840602.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_840603.1 12 TMHs; aromatic amino acid APC transporter, AAT family YP_840619.1 Catalyzes the oxidation of dihydrolipoamide to lipoamide YP_840626.1 catalyzes the release of C-terminal glutamate residues from N-acylating moieties YP_840628.1 PLDc YP_840632.1 transcriptional regulator, LysR-family YP_840634.1 1 TMHs YP_840635.1 12 TMHs YP_840643.1 5 transmembrane helices YP_840645.1 ABC-type transporter, ATPase component: PepT family YP_840647.1 4 TMHs YP_840648.1 6 TMHs YP_840652.1 transcriptional regulator, XRE-family YP_840659.1 11 strong transmembrane helices (TMpred) YP_840660.1 transcriptional regulator, TetR/AcrR-family YP_840662.1 14 TMHs; MFS transporter, DHA2 family YP_840667.1 HTH_ARAC; transcriptional regulator, AraC family YP_840668.1 cNMP; HTH_CRP YP_840669.1 activates fatty acids by binding to coenzyme A YP_840680.1 transcriptional regulator, TetR/AcrR-family YP_840687.1 signal peptide YP_840690.1 transcriptional regulator, GntR-family YP_840692.1 12 TMHs; MFS transporter, ACS family YP_840694.1 12 TMHs; MFS transporter, AAHS family YP_840697.1 8 TMHs YP_840698.1 9 TMHs YP_840699.1 several transmembrane helices (TMpred: 7 or 8) YP_840704.1 transcriptional regulator, PadR-family YP_840710.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_840714.1 transcriptional regulator, AraC-family YP_840721.1 12 TMHs YP_840722.1 several transmembrane helices (TMpred:8 or 9) YP_840730.1 transcriptional regulator, GlvR-family YP_840735.1 DUF1; DUF2; HTH_MARR YP_840736.1 two CBS domains YP_840738.1 12 TMHs; MFS transporter, ACS family YP_840740.1 transcriptional regulator, LysR-family YP_840743.1 DHBP synthase; functions during riboflavin biosynthesis YP_840746.1 several transmembrane helices (TMpred) YP_840749.1 involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan YP_840750.1 necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space YP_840752.1 12 TMHs YP_840753.1 3 TMHs YP_840754.1 11 TMHs YP_840757.1 probable N-terminal signal peptide YP_840763.1 4 TMHs YP_840775.1 catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol) YP_840784.1 activates fatty acids by binding to coenzyme A YP_840814.1 6 TMHs YP_840820.1 paralogs to the E1 component of pyruvate dehydrogenase subunit E1 YP_840857.1 14 TMHs YP_840863.1 Short chain dehydrogenase YP_840867.1 Hsp31 stabilizes early unfolding protein intermediates under severe heat stress YP_840874.1 member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake YP_840881.1 with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA; involved in phenylacetate degradation YP_840882.1 with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA YP_840884.1 catalyzes conversion of 1-aminocyclopropane-1-carboxylate to ammonia and alpha-ketobutyrate YP_840888.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_840903.1 class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis YP_840904.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_840906.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate YP_840914.1 type III RuBisCO; involved in carbon fixation YP_840917.1 activates fatty acids by binding to coenzyme A YP_840920.1 11 TMHs YP_840972.1 4 TMHs YP_840976.1 2 TMHs YP_840978.1 12 TMHs YP_840989.1 CbbBc-like YP_840995.1 4 TMHs YP_841001.1 11 TMHs YP_841003.1 12 TMHs YP_841008.1 12 TMHs YP_841016.1 7 TMHs YP_841018.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_841019.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_841023.1 12 TMHs YP_841029.1 with SufCD activates cysteine desulfurase SufS YP_841065.1 12 TMHs YP_841076.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain YP_841094.1 2 TMHs YP_841098.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine YP_841102.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity YP_841103.1 9 TMHs YP_841108.1 Catalyzes the deamination of cytosine to uracil and ammonia YP_841116.1 5 TMHs YP_841117.1 5 TMHs YP_841124.1 11 TMHs YP_841144.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_841146.1 catalyzes the formation of acetyl phosphate from acetyl-CoA and phosphate; can also act with other short-chain acyl-CoAs YP_841159.1 5 TMHs YP_841182.1 FabB; beta-ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_841186.1 An oxygenase that acts to open the ring of homogentisate formingmaleylacetoacetate as part of the catabolism of L-tyrosine and L-phenylalanine YP_841197.1 4 TMHs YP_841208.1 AliA; in Rhodopseudomonas palustris, this enzyme was found to act on 3-chlorobenzoate and allows the organism to grow on this substrate YP_841212.1 transcriptional regulator, MarR-family YP_841217.1 12 TMHs YP_841222.1 HTH_XRE (bacterial plasmid copy control protein,bacterial methylases) YP_841223.1 Transcriptional regulator YP_841224.1 activates fatty acids by binding to coenzyme A YP_841226.1 catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA YP_841227.1 catalyzes the formation of formyl-CoA from oxalyl-CoA YP_841228.1 12 TMHs; MFS transporter, OFA family YP_841230.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm YP_841232.1 catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA YP_841234.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis YP_841236.1 involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans YP_841237.1 transcriptional regulator, GntR-family YP_841250.1 highest homologies to Enoyl-CoA hydratase YP_841251.1 predicted ferredoxin protein YP_841265.1 zinc metallopeptidases YP_841272.1 12 TMHs YP_841276.1 transcriptional regulator, AraC-family YP_841277.1 Enables the enzymatic reduction of mercuric ions to elemental mercury YP_841290.1 putative peptidase, S33 family, containing epoxid hydrolase domain YP_841292.1 14 TMHs YP_841296.1 2 TMHs YP_841299.1 transcriptional regulator, LysR-family YP_841316.1 transcriptional regulator, AraC-family YP_841317.1 similarity to short-chain alcohol dehydrogenases YP_841320.1 3 TMHs YP_841321.1 3 TMHs YP_841324.1 high homologies to 2-keto-3-deoxygluconate kinase kdgk and to ribokinase family YP_841342.1 12 TMHs YP_841346.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_841356.1 transcriptional regulator, IclR-family YP_841364.1 12 TMHs YP_841367.1 10 TMHs YP_841369.1 11 TMHs YP_841379.1 8 TMHs YP_841381.1 2 TMHs YP_841382.1 catalyzes the formation of acetyl phosphate and sulfite from 2-sulfoacetaldehyde; is active when grown on taurine as a sole carbon source YP_841384.1 8 TMHs YP_841385.1 12 TMHs YP_841386.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia YP_841388.1 transcriptional regulator, GntR-family YP_841395.1 12 TMHs YP_841402.1 12 TMHs YP_841423.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_841426.1 cleaves the ring of 2,3-dihydro-2,3-dihydroxybenzoyl-CoA forming 6-hydroxy-3-hexenoyl-CoA YP_841427.1 consists of N-terminal helix-turn-helix domain and C-terminal shikimate kinase-like domain which may bind benzoyl-CoA; controls inducible expression of the bzd catabolic operon that is involved in the anaerobic catabolism of benzoate YP_841431.1 12 TMHs YP_841436.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_841444.1 signal peptide YP_841452.1 12 TMHs YP_841457.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer YP_841464.1 12 TMHs YP_841465.1 catalyzes the formation of phosphonoacetaldehyde from 2-aminoethylphosphonate and pyruvate YP_841468.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine YP_841478.1 11 TMHs YP_841491.1 4 TMHs YP_841492.1 catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates YP_841501.1 10 TMHs YP_841521.1 8 TMHs YP_841522.1 10 TMHs YP_841528.1 differing codon usage, similiar to pHG1 DNA YP_841529.1 differing coding usage, similar to pHG1 DNA YP_841531.1 differing codon usage, similar to pHG1 DNA YP_841533.1 differing coding usage, similar to pHG1 encoded phasin PhaP2 YP_841535.1 differing coding usage, similar to pHG1 DNA YP_841536.1 differing coding usage, similar to pHG1 DNA YP_841538.1 differing coding usage, similar to pHG1 DNA YP_841549.1 7 TMHs YP_841550.1 10 TMHs YP_841556.1 2 TMHs YP_841561.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins YP_841566.1 4 TMHs; putative transporter, APC superfamily YP_841568.1 contains 3 Pfam:MHYT signal domains YP_841570.1 signal peptide YP_841573.1 signal peptide YP_841574.1 signal peptide YP_841575.1 signal peptide; TLC; transmembrane YP_841579.1 12 TMHs YP_841581.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide YP_841584.1 12 TMHs; MFS transporter, MHS family YP_841595.1 14 TMHs YP_841607.1 IrgA; binds ferric enterobactin; irgA gene expression is repressed by Fur and induced by the divergently transcribed upstream gene irgB; outer membrane protein; involved in iron metabolism YP_841609.1 14 TMHs YP_841613.1 9 TMHs YP_841629.1 4 TMHs YP_841630.1 5 TMHs YP_841634.1 2 TMHs YP_841639.1 12 TMHs YP_841643.1 catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine YP_841646.1 12 TMHs YP_841652.1 3 TMHs YP_841653.1 3 TMHs YP_841654.1 11 TMHs YP_841674.1 catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid YP_841677.1 12 TMHs YP_841681.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_841694.1 8 TMHs YP_841707.1 4 TMHs YP_841710.1 12 TMHs YP_841729.1 6 TMHs YP_841736.1 5 TMHs YP_841737.1 6 TMHs YP_841749.1 10 TMHs YP_841757.1 6 TMHs YP_841766.1 12 TMHs YP_841772.1 12 TMHs YP_841775.1 12 TMHs YP_841776.1 12 TMHs YP_841780.1 5 TMHs YP_841787.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_841798.1 catalyzes the formation of protocatechuate from 4-hydroxybenzoate YP_841801.1 Catalyzes the cycloisomerization of cis,cis-muconate YP_841805.1 11 TMHs YP_841809.1 12 TMHs YP_841810.1 5 TMHs YP_841819.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia YP_841824.1 6 TMHs YP_841835.1 14 TMHs YP_841836.1 Involved in anaerobic NO protection and iron metabolism YP_841837.1 Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon YP_841845.1 2 TMHs YP_841864.1 catalyzes the ATP dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA YP_841872.1 structural flagella protein YP_841880.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod YP_841881.1 One of three proteins involved in switching the direction of the flagellar rotation YP_841882.1 binds to and inhibits the function of flagella specific ATPase FliI YP_841916.1 7 TMHs YP_841919.1 10 TMHs YP_841925.1 Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription YP_841932.1 10 TMHs YP_841934.1 9 TMHs YP_841937.1 signal peptide YP_841955.1 ABC-type transporter, periplasmic component YP_841957.1 transcriptional regulator, AraC-family YP_841960.1 7 TMHs YP_841971.1 formamide amidohydrolase; catalyzes the hydrolysis of formamide to formate YP_841972.1 catalyzes the formation of S-ureidoglycolate and urea from allantoate YP_841974.1 10 TMHs YP_841976.1 6 TMHs YP_841977.1 3 TMHs YP_841984.1 12 TMHs YP_841990.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_841993.1 12 TMHs YP_842000.1 4 TMHs YP_842016.1 3 TMHs YP_842022.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_842023.1 12 TMHs YP_842031.1 transcriptional regulator, AraC-family YP_842042.1 12 TMHs YP_842043.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis YP_842046.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_842051.1 10 TMHs YP_842052.1 Modulates the activities of several enzymes which are inactive in their acetylated form YP_842060.1 4 TMHs YP_842066.1 ANATO YP_842068.1 13 TMHs YP_842078.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_842079.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate YP_842080.1 3 TMHs YP_842081.1 10 TMHs YP_842083.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein YP_842089.1 h16_B2577 YP_842090.1 10 TMHs