-- dump date 20120504_160035 -- class Genbank::misc_feature -- table misc_feature_note -- id note 264198000001 enoyl-CoA hydratase; Provisional; Region: PRK07658 264198000002 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198000003 substrate binding site [chemical binding]; other site 264198000004 oxyanion hole (OAH) forming residues; other site 264198000005 trimer interface [polypeptide binding]; other site 264198000006 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 264198000007 AMP-binding enzyme; Region: AMP-binding; cl15778 264198000008 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198000009 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 264198000010 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 264198000011 catalytic loop [active] 264198000012 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 264198000013 iron binding site [ion binding]; other site 264198000014 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 264198000015 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 264198000016 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 264198000017 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 264198000018 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 264198000019 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264198000020 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 264198000021 putative hydrophobic ligand binding site [chemical binding]; other site 264198000022 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198000023 Helix-turn-helix domains; Region: HTH; cl00088 264198000024 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264198000025 dimerization interface [polypeptide binding]; other site 264198000026 Transcriptional regulators [Transcription]; Region: PurR; COG1609 264198000027 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 264198000028 DNA binding site [nucleotide binding] 264198000029 domain linker motif; other site 264198000030 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 264198000031 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 264198000032 Dehydratase family; Region: ILVD_EDD; cl00340 264198000033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198000034 NMT1-like family; Region: NMT1_2; cl15260 264198000035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198000036 NMT1-like family; Region: NMT1_2; cl15260 264198000037 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 264198000038 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 264198000039 active site pocket [active] 264198000040 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 264198000041 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198000042 tartrate dehydrogenase; Provisional; Region: PRK08194 264198000043 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 264198000044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198000045 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198000046 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 264198000047 tetramerization interface [polypeptide binding]; other site 264198000048 NAD(P) binding site [chemical binding]; other site 264198000049 catalytic residues [active] 264198000050 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 264198000051 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198000052 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198000053 DNA-binding site [nucleotide binding]; DNA binding site 264198000054 Transcriptional regulators [Transcription]; Region: FadR; COG2186 264198000055 FCD domain; Region: FCD; cl11656 264198000056 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 264198000057 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 264198000058 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198000059 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 264198000060 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 264198000061 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 264198000062 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 264198000063 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 264198000064 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 264198000065 Phosphate-starvation-inducible E; Region: PsiE; cl01264 264198000066 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198000067 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198000068 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 264198000069 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 264198000070 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 264198000071 Clp amino terminal domain; Region: Clp_N; pfam02861 264198000072 Clp amino terminal domain; Region: Clp_N; pfam02861 264198000073 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198000074 Walker A motif; other site 264198000075 ATP binding site [chemical binding]; other site 264198000076 Walker B motif; other site 264198000077 arginine finger; other site 264198000078 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198000079 Walker A motif; other site 264198000080 ATP binding site [chemical binding]; other site 264198000081 Walker B motif; other site 264198000082 arginine finger; other site 264198000083 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 264198000084 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264198000085 non-specific DNA binding site [nucleotide binding]; other site 264198000086 salt bridge; other site 264198000087 sequence-specific DNA binding site [nucleotide binding]; other site 264198000088 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 264198000089 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 264198000090 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 264198000091 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 264198000092 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198000093 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 264198000094 active site 264198000095 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 264198000096 homotrimer interaction site [polypeptide binding]; other site 264198000097 putative active site [active] 264198000098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198000099 NMT1-like family; Region: NMT1_2; cl15260 264198000100 Flavin Reductases; Region: FlaRed; cl00801 264198000101 Helix-turn-helix domains; Region: HTH; cl00088 264198000102 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198000103 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198000104 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 264198000105 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198000106 NAD(P) binding site [chemical binding]; other site 264198000107 catalytic residues [active] 264198000108 DDE superfamily endonuclease; Region: DDE_4; cl15789 264198000109 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 264198000110 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264198000111 DDE superfamily endonuclease; Region: DDE_4; cl15789 264198000112 Helix-turn-helix domains; Region: HTH; cl00088 264198000113 putative transposase OrfB; Reviewed; Region: PHA02517 264198000114 HTH-like domain; Region: HTH_21; pfam13276 264198000115 Integrase core domain; Region: rve; cl01316 264198000116 Integrase core domain; Region: rve_3; cl15866 264198000117 acyl-CoA synthetase; Validated; Region: PRK08162 264198000118 AMP-binding enzyme; Region: AMP-binding; cl15778 264198000119 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198000120 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 264198000121 putative FMN binding site [chemical binding]; other site 264198000122 benzoate transport; Region: 2A0115; TIGR00895 264198000123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198000124 putative substrate translocation pore; other site 264198000125 short chain dehydrogenase; Provisional; Region: PRK08628 264198000126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198000127 NAD(P) binding site [chemical binding]; other site 264198000128 active site 264198000129 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 264198000130 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264198000131 dimer interface [polypeptide binding]; other site 264198000132 active site 264198000133 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264198000134 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198000135 ligand binding site [chemical binding]; other site 264198000136 flexible hinge region; other site 264198000137 Helix-turn-helix domains; Region: HTH; cl00088 264198000138 putative switch regulator; other site 264198000139 non-specific DNA interactions [nucleotide binding]; other site 264198000140 DNA binding site [nucleotide binding] 264198000141 sequence specific DNA binding site [nucleotide binding]; other site 264198000142 putative cAMP binding site [chemical binding]; other site 264198000143 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198000144 Helix-turn-helix domains; Region: HTH; cl00088 264198000145 Tannase and feruloyl esterase; Region: Tannase; pfam07519 264198000146 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264198000147 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198000148 DNA-binding site [nucleotide binding]; DNA binding site 264198000149 FCD domain; Region: FCD; cl11656 264198000150 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198000151 enoyl-CoA hydratase; Provisional; Region: PRK06144 264198000152 substrate binding site [chemical binding]; other site 264198000153 oxyanion hole (OAH) forming residues; other site 264198000154 trimer interface [polypeptide binding]; other site 264198000155 NMT1-like family; Region: NMT1_2; cl15260 264198000156 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198000157 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198000158 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 264198000159 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 264198000160 putative NAD(P) binding site [chemical binding]; other site 264198000161 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198000162 TM-ABC transporter signature motif; other site 264198000163 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198000164 TM-ABC transporter signature motif; other site 264198000165 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264198000166 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 264198000167 Walker A/P-loop; other site 264198000168 ATP binding site [chemical binding]; other site 264198000169 Q-loop/lid; other site 264198000170 ABC transporter signature motif; other site 264198000171 Walker B; other site 264198000172 D-loop; other site 264198000173 H-loop/switch region; other site 264198000174 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198000175 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 264198000176 Walker A/P-loop; other site 264198000177 ATP binding site [chemical binding]; other site 264198000178 Q-loop/lid; other site 264198000179 ABC transporter signature motif; other site 264198000180 Walker B; other site 264198000181 D-loop; other site 264198000182 H-loop/switch region; other site 264198000183 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198000184 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 264198000185 putative ligand binding site [chemical binding]; other site 264198000186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198000187 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 264198000188 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 264198000189 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 264198000190 NAD(P) binding site [chemical binding]; other site 264198000191 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 264198000192 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198000193 tetrameric interface [polypeptide binding]; other site 264198000194 NAD binding site [chemical binding]; other site 264198000195 catalytic residues [active] 264198000196 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198000197 Helix-turn-helix domains; Region: HTH; cl00088 264198000198 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198000199 dimerization interface [polypeptide binding]; other site 264198000200 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264198000201 active site 264198000202 DNA binding site [nucleotide binding] 264198000203 Int/Topo IB signature motif; other site 264198000204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198000205 metabolite-proton symporter; Region: 2A0106; TIGR00883 264198000206 putative substrate translocation pore; other site 264198000207 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264198000208 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 264198000209 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 264198000210 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 264198000211 VCBS repeat; Region: VCBS_repeat; TIGR01965 264198000212 VCBS repeat; Region: VCBS_repeat; TIGR01965 264198000213 VCBS repeat; Region: VCBS_repeat; TIGR01965 264198000214 VCBS repeat; Region: VCBS_repeat; TIGR01965 264198000215 VCBS repeat; Region: VCBS_repeat; TIGR01965 264198000216 VCBS repeat; Region: VCBS_repeat; TIGR01965 264198000217 VCBS repeat; Region: VCBS_repeat; TIGR01965 264198000218 VCBS repeat; Region: VCBS_repeat; TIGR01965 264198000219 VCBS repeat; Region: VCBS_repeat; TIGR01965 264198000220 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 264198000221 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 264198000222 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198000223 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198000224 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39_likeD; cd02421 264198000225 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 264198000226 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 264198000227 ABC-type bacteriocin exporters. Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors which have N-terminal leader peptides that share similarities in amino acid sequence and contain a conserved processing site of two...; Region: ABCC_bacteriocin_exporters; cd03245 264198000228 Walker A/P-loop; other site 264198000229 ATP binding site [chemical binding]; other site 264198000230 Q-loop/lid; other site 264198000231 ABC transporter signature motif; other site 264198000232 Walker B; other site 264198000233 D-loop; other site 264198000234 H-loop/switch region; other site 264198000235 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 264198000236 Transposase domain (DUF772); Region: DUF772; pfam05598 264198000237 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264198000238 DDE superfamily endonuclease; Region: DDE_4; cl15789 264198000239 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 264198000240 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 264198000241 conserved cys residue [active] 264198000242 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198000243 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 264198000244 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 264198000245 conserved cys residue [active] 264198000246 NMT1-like family; Region: NMT1_2; cl15260 264198000247 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264198000248 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 264198000249 N-terminal domain interface [polypeptide binding]; other site 264198000250 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 264198000251 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 264198000252 Amidase; Region: Amidase; cl11426 264198000253 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 264198000254 active site 264198000255 dimer interface [polypeptide binding]; other site 264198000256 metal binding site [ion binding]; metal-binding site 264198000257 LysR family transcriptional regulator; Provisional; Region: PRK14997 264198000258 Helix-turn-helix domains; Region: HTH; cl00088 264198000259 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198000260 dimerization interface [polypeptide binding]; other site 264198000261 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 264198000262 putative FMN binding site [chemical binding]; other site 264198000263 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 264198000264 Zn binding site [ion binding]; other site 264198000265 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 264198000266 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198000267 Zn binding site [ion binding]; other site 264198000268 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 264198000269 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 264198000270 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 264198000271 Transposase; Region: DDE_Tnp_ISL3; pfam01610 264198000272 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 264198000273 IHF dimer interface [polypeptide binding]; other site 264198000274 IHF - DNA interface [nucleotide binding]; other site 264198000275 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 264198000276 active site 264198000277 Int/Topo IB signature motif; other site 264198000278 catalytic residues [active] 264198000279 DNA binding site [nucleotide binding] 264198000280 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264198000281 non-specific DNA binding site [nucleotide binding]; other site 264198000282 salt bridge; other site 264198000283 sequence-specific DNA binding site [nucleotide binding]; other site 264198000284 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 264198000285 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 264198000286 RES domain; Region: RES; cl02411 264198000287 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 264198000288 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 264198000289 Archaeal ATPase; Region: Arch_ATPase; pfam01637 264198000290 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 264198000291 H-NS histone family; Region: Histone_HNS; pfam00816 264198000292 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 264198000293 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667 264198000294 nudix motif; other site 264198000295 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 264198000296 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 264198000297 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 264198000298 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 264198000299 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 264198000300 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264198000301 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 264198000302 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264198000303 DNA binding residues [nucleotide binding] 264198000304 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 264198000305 DNA-binding site [nucleotide binding]; DNA binding site 264198000306 RNA-binding motif; other site 264198000307 Cache domain; Region: Cache_1; pfam02743 264198000308 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264198000309 PAS fold; Region: PAS_4; pfam08448 264198000310 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 264198000311 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198000312 metal binding site [ion binding]; metal-binding site 264198000313 active site 264198000314 I-site; other site 264198000315 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 264198000316 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 264198000317 NAD(P) binding site [chemical binding]; other site 264198000318 homotetramer interface [polypeptide binding]; other site 264198000319 homodimer interface [polypeptide binding]; other site 264198000320 active site 264198000321 Phasin protein; Region: Phasin_2; cl11491 264198000322 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 264198000323 active site 264198000324 nucleophile elbow; other site 264198000325 CHASE domain; Region: CHASE; cl01369 264198000326 GAF domain; Region: GAF_2; pfam13185 264198000327 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198000328 metal binding site [ion binding]; metal-binding site 264198000329 active site 264198000330 I-site; other site 264198000331 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264198000332 Uncharacterized conserved protein [Function unknown]; Region: COG4278 264198000333 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 264198000334 DNA-binding site [nucleotide binding]; DNA binding site 264198000335 RNA-binding motif; other site 264198000336 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 264198000337 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 264198000338 DXD motif; other site 264198000339 PilZ domain; Region: PilZ; cl01260 264198000340 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 264198000341 benzoate transport; Region: 2A0115; TIGR00895 264198000342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198000343 putative substrate translocation pore; other site 264198000344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198000345 putative substrate translocation pore; other site 264198000346 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 264198000347 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198000348 NAD(P) binding site [chemical binding]; other site 264198000349 active site 264198000350 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198000351 classical (c) SDRs; Region: SDR_c; cd05233 264198000352 NAD(P) binding site [chemical binding]; other site 264198000353 active site 264198000354 enoyl-CoA hydratase; Provisional; Region: PRK06688 264198000355 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198000356 substrate binding site [chemical binding]; other site 264198000357 oxyanion hole (OAH) forming residues; other site 264198000358 trimer interface [polypeptide binding]; other site 264198000359 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 264198000360 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198000361 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198000362 Flavin Reductases; Region: FlaRed; cl00801 264198000363 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 264198000364 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 264198000365 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198000366 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 264198000367 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264198000368 Helix-turn-helix domains; Region: HTH; cl00088 264198000369 benzoate transport; Region: 2A0115; TIGR00895 264198000370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198000371 putative substrate translocation pore; other site 264198000372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198000373 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 264198000374 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 264198000375 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 264198000376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198000377 NMT1-like family; Region: NMT1_2; cl15260 264198000378 Flavin Reductases; Region: FlaRed; cl00801 264198000379 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 264198000380 classical (c) SDR, subgroup 10; Region: SDR_c10; cd05373 264198000381 putative NAD(P) binding site [chemical binding]; other site 264198000382 active site 264198000383 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 264198000384 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 264198000385 FMN binding site [chemical binding]; other site 264198000386 substrate binding site [chemical binding]; other site 264198000387 putative catalytic residue [active] 264198000388 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 264198000389 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 264198000390 putative catalytic residue [active] 264198000391 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 264198000392 AMP-binding enzyme; Region: AMP-binding; cl15778 264198000393 AMP-binding enzyme; Region: AMP-binding; cl15778 264198000394 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198000395 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 264198000396 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 264198000397 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 264198000398 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 264198000399 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 264198000400 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 264198000401 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 264198000402 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 264198000403 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 264198000404 putative catalytic residue [active] 264198000405 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 264198000406 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264198000407 dimer interface [polypeptide binding]; other site 264198000408 active site 264198000409 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 264198000410 classical (c) SDR, subgroup 10; Region: SDR_c10; cd05373 264198000411 putative NAD(P) binding site [chemical binding]; other site 264198000412 active site 264198000413 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198000414 Helix-turn-helix domains; Region: HTH; cl00088 264198000415 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 264198000416 AMP-binding enzyme; Region: AMP-binding; cl15778 264198000417 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198000418 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 264198000419 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 264198000420 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198000421 active site 264198000422 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 264198000423 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 264198000424 NADH(P)-binding; Region: NAD_binding_10; pfam13460 264198000425 NADP binding site [chemical binding]; other site 264198000426 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198000427 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198000428 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198000429 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 264198000430 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 264198000431 DDE superfamily endonuclease; Region: DDE_4; cl15789 264198000432 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264198000433 DDE superfamily endonuclease; Region: DDE_4; cl15789 264198000434 acyl-CoA synthetase; Provisional; Region: PRK12582 264198000435 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 264198000436 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264198000437 FeS/SAM binding site; other site 264198000438 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198000439 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 264198000440 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264198000441 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198000442 ligand binding site [chemical binding]; other site 264198000443 Helix-turn-helix domains; Region: HTH; cl00088 264198000444 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264198000445 Uncharacterized conserved protein [Function unknown]; Region: COG5361 264198000446 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 264198000447 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 264198000448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198000449 NMT1-like family; Region: NMT1_2; cl15260 264198000450 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 264198000451 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 264198000452 NAD binding site [chemical binding]; other site 264198000453 substrate binding site [chemical binding]; other site 264198000454 catalytic Zn binding site [ion binding]; other site 264198000455 structural Zn binding site [ion binding]; other site 264198000456 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 264198000457 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 264198000458 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 264198000459 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 264198000460 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 264198000461 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198000462 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198000463 NMT1-like family; Region: NMT1_2; cl15260 264198000464 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 264198000465 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 264198000466 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 264198000467 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 264198000468 L-threonine 3-dehydrogenase; Region: tdh; TIGR00692 264198000469 putative NAD(P) binding site [chemical binding]; other site 264198000470 catalytic Zn binding site [ion binding]; other site 264198000471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198000472 metabolite-proton symporter; Region: 2A0106; TIGR00883 264198000473 putative substrate translocation pore; other site 264198000474 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198000475 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 264198000476 NAD(P) binding site [chemical binding]; other site 264198000477 active site 264198000478 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 264198000479 histidinol dehydrogenase; Region: hisD; TIGR00069 264198000480 NAD binding site [chemical binding]; other site 264198000481 dimerization interface [polypeptide binding]; other site 264198000482 product binding site; other site 264198000483 substrate binding site [chemical binding]; other site 264198000484 zinc binding site [ion binding]; other site 264198000485 catalytic residues [active] 264198000486 Transcriptional regulators [Transcription]; Region: PurR; COG1609 264198000487 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 264198000488 DNA binding site [nucleotide binding] 264198000489 domain linker motif; other site 264198000490 This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273 264198000491 putative dimerization interface [polypeptide binding]; other site 264198000492 putative ligand binding site [chemical binding]; other site 264198000493 Helix-turn-helix domains; Region: HTH; cl00088 264198000494 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 264198000495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198000496 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 264198000497 Uncharacterized conserved protein [Function unknown]; Region: COG3496 264198000498 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 264198000499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198000500 S-adenosylmethionine binding site [chemical binding]; other site 264198000501 MFS/sugar transport protein; Region: MFS_2; pfam13347 264198000502 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 264198000503 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198000504 NAD(P) binding site [chemical binding]; other site 264198000505 active site 264198000506 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 264198000507 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 264198000508 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198000509 substrate binding pocket [chemical binding]; other site 264198000510 membrane-bound complex binding site; other site 264198000511 hinge residues; other site 264198000512 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 264198000513 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198000514 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 264198000515 substrate binding site [chemical binding]; other site 264198000516 oxyanion hole (OAH) forming residues; other site 264198000517 trimer interface [polypeptide binding]; other site 264198000518 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198000519 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 264198000520 substrate binding site [chemical binding]; other site 264198000521 oxyanion hole (OAH) forming residues; other site 264198000522 trimer interface [polypeptide binding]; other site 264198000523 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198000524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198000525 NAD(P) binding site [chemical binding]; other site 264198000526 active site 264198000527 acyl-CoA synthetase; Validated; Region: PRK08162 264198000528 AMP-binding enzyme; Region: AMP-binding; cl15778 264198000529 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198000530 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 264198000531 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 264198000532 active site 264198000533 FMN binding site [chemical binding]; other site 264198000534 2,4-decadienoyl-CoA binding site; other site 264198000535 catalytic residue [active] 264198000536 4Fe-4S cluster binding site [ion binding]; other site 264198000537 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198000538 Helix-turn-helix domains; Region: HTH; cl00088 264198000539 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 264198000540 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 264198000541 Cupin domain; Region: Cupin_2; cl09118 264198000542 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198000543 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198000544 Helix-turn-helix domains; Region: HTH; cl00088 264198000545 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198000546 dimerization interface [polypeptide binding]; other site 264198000547 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 264198000548 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 264198000549 putative NAD(P) binding site [chemical binding]; other site 264198000550 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 264198000551 catalytic residue [active] 264198000552 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 264198000553 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264198000554 LysR family transcriptional regulator; Provisional; Region: PRK14997 264198000555 Helix-turn-helix domains; Region: HTH; cl00088 264198000556 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198000557 putative effector binding pocket; other site 264198000558 dimerization interface [polypeptide binding]; other site 264198000559 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 264198000560 Helix-turn-helix domains; Region: HTH; cl00088 264198000561 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 264198000562 dimerization interface [polypeptide binding]; other site 264198000563 substrate binding pocket [chemical binding]; other site 264198000564 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 264198000565 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 264198000566 putative active site [active] 264198000567 Zn binding site [ion binding]; other site 264198000568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198000569 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198000570 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 264198000571 homotrimer interaction site [polypeptide binding]; other site 264198000572 putative active site [active] 264198000573 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 264198000574 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 264198000575 Cupin domain; Region: Cupin_2; cl09118 264198000576 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 264198000577 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198000578 DNA-binding site [nucleotide binding]; DNA binding site 264198000579 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198000580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198000581 homodimer interface [polypeptide binding]; other site 264198000582 catalytic residue [active] 264198000583 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 264198000584 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198000585 classical (c) SDRs; Region: SDR_c; cd05233 264198000586 NAD(P) binding site [chemical binding]; other site 264198000587 active site 264198000588 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 264198000589 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 264198000590 putative active site [active] 264198000591 putative metal binding site [ion binding]; other site 264198000592 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 264198000593 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 264198000594 NAD(P) binding site [chemical binding]; other site 264198000595 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198000596 Helix-turn-helix domains; Region: HTH; cl00088 264198000597 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198000598 dimerization interface [polypeptide binding]; other site 264198000599 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 264198000600 HipA N-terminal domain; Region: Couple_hipA; cl11853 264198000601 HipA-like N-terminal domain; Region: HipA_N; pfam07805 264198000602 HipA-like C-terminal domain; Region: HipA_C; pfam07804 264198000603 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 264198000604 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 264198000605 active site 264198000606 metal binding site [ion binding]; metal-binding site 264198000607 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 264198000608 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 264198000609 Initiator Replication protein; Region: Rep_3; cl03080 264198000610 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 264198000611 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264198000612 P-loop; other site 264198000613 Magnesium ion binding site [ion binding]; other site 264198000614 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264198000615 Magnesium ion binding site [ion binding]; other site 264198000616 ParB-like nuclease domain; Region: ParBc; cl02129 264198000617 Phage integrase protein; Region: DUF3701; pfam12482 264198000618 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 264198000619 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264198000620 active site 264198000621 DNA binding site [nucleotide binding] 264198000622 Int/Topo IB signature motif; other site 264198000623 Double zinc ribbon; Region: DZR; pfam12773 264198000624 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 264198000625 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 264198000626 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 264198000627 cyclase homology domain; Region: CHD; cd07302 264198000628 nucleotidyl binding site; other site 264198000629 metal binding site [ion binding]; metal-binding site 264198000630 dimer interface [polypeptide binding]; other site 264198000631 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198000632 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 264198000633 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 264198000634 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 264198000635 putative active site [active] 264198000636 putative metal binding site [ion binding]; other site 264198000637 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 264198000638 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198000639 Walker A motif; other site 264198000640 ATP binding site [chemical binding]; other site 264198000641 Walker B motif; other site 264198000642 arginine finger; other site 264198000643 Helix-turn-helix domains; Region: HTH; cl00088 264198000644 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 264198000645 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 264198000646 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 264198000647 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 264198000648 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 264198000649 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 264198000650 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 264198000651 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 264198000652 AMP-binding enzyme; Region: AMP-binding; cl15778 264198000653 AMP-binding enzyme; Region: AMP-binding; cl15778 264198000654 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 264198000655 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 264198000656 oligomeric interface; other site 264198000657 putative active site [active] 264198000658 homodimer interface [polypeptide binding]; other site 264198000659 Sulfate transporter family; Region: Sulfate_transp; cl15842 264198000660 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 264198000661 Sulfate transporter family; Region: Sulfate_transp; cl15842 264198000662 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 264198000663 Helix-turn-helix domains; Region: HTH; cl00088 264198000664 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 264198000665 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 264198000666 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 264198000667 Integrase core domain; Region: rve; cl01316 264198000668 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 264198000669 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 264198000670 AMP-binding enzyme; Region: AMP-binding; cl15778 264198000671 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 264198000672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198000673 NAD(P) binding site [chemical binding]; other site 264198000674 active site 264198000675 Acylphosphatase; Region: Acylphosphatase; cl00551 264198000676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198000677 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198000678 putative substrate translocation pore; other site 264198000679 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198000680 active site 264198000681 FtsH Extracellular; Region: FtsH_ext; pfam06480 264198000682 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 264198000683 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198000684 Walker A motif; other site 264198000685 ATP binding site [chemical binding]; other site 264198000686 Walker B motif; other site 264198000687 arginine finger; other site 264198000688 Peptidase family M41; Region: Peptidase_M41; pfam01434 264198000689 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 264198000690 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 264198000691 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 264198000692 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264198000693 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264198000694 S-adenosylmethionine synthetase (AdoMet synthetase); Region: AdoMet_Synthase; pfam01941 264198000695 LemA family; Region: LemA; cl00742 264198000696 Repair protein; Region: Repair_PSII; cl01535 264198000697 Repair protein; Region: Repair_PSII; cl01535 264198000698 Predicted membrane protein [Function unknown]; Region: COG3174 264198000699 Helix-turn-helix domains; Region: HTH; cl00088 264198000700 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264198000701 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264198000702 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 264198000703 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198000704 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 264198000705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198000706 putative substrate translocation pore; other site 264198000707 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198000708 Helix-turn-helix domains; Region: HTH; cl00088 264198000709 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198000710 putative effector binding pocket; other site 264198000711 dimerization interface [polypeptide binding]; other site 264198000712 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198000713 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 264198000714 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750 264198000715 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198000716 Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360 264198000717 putative ligand binding site [chemical binding]; other site 264198000718 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198000719 TM-ABC transporter signature motif; other site 264198000720 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198000721 TM-ABC transporter signature motif; other site 264198000722 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198000723 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 264198000724 Walker A/P-loop; other site 264198000725 ATP binding site [chemical binding]; other site 264198000726 Q-loop/lid; other site 264198000727 ABC transporter signature motif; other site 264198000728 Walker B; other site 264198000729 D-loop; other site 264198000730 H-loop/switch region; other site 264198000731 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264198000732 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 264198000733 Walker A/P-loop; other site 264198000734 ATP binding site [chemical binding]; other site 264198000735 Q-loop/lid; other site 264198000736 ABC transporter signature motif; other site 264198000737 Walker B; other site 264198000738 D-loop; other site 264198000739 H-loop/switch region; other site 264198000740 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198000741 eyelet of channel; other site 264198000742 trimer interface [polypeptide binding]; other site 264198000743 Helix-turn-helix domains; Region: HTH; cl00088 264198000744 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 264198000745 AsnC family; Region: AsnC_trans_reg; pfam01037 264198000746 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 264198000747 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 264198000748 dimer interface [polypeptide binding]; other site 264198000749 PYR/PP interface [polypeptide binding]; other site 264198000750 TPP binding site [chemical binding]; other site 264198000751 substrate binding site [chemical binding]; other site 264198000752 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 264198000753 TPP-binding site [chemical binding]; other site 264198000754 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 264198000755 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 264198000756 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 264198000757 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 264198000758 NAD binding site [chemical binding]; other site 264198000759 Phe binding site; other site 264198000760 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264198000761 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198000762 DNA-binding site [nucleotide binding]; DNA binding site 264198000763 FCD domain; Region: FCD; cl11656 264198000764 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 264198000765 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 264198000766 trimer interface [polypeptide binding]; other site 264198000767 putative metal binding site [ion binding]; other site 264198000768 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 264198000769 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 264198000770 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 264198000771 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 264198000772 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198000773 classical (c) SDRs; Region: SDR_c; cd05233 264198000774 NAD(P) binding site [chemical binding]; other site 264198000775 active site 264198000776 short chain dehydrogenase; Provisional; Region: PRK12829 264198000777 classical (c) SDRs; Region: SDR_c; cd05233 264198000778 NAD(P) binding site [chemical binding]; other site 264198000779 active site 264198000780 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 264198000781 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 264198000782 Helix-turn-helix domains; Region: HTH; cl00088 264198000783 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 264198000784 putative substrate binding pocket [chemical binding]; other site 264198000785 putative dimerization interface [polypeptide binding]; other site 264198000786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198000787 putative substrate translocation pore; other site 264198000788 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198000789 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198000790 trimer interface [polypeptide binding]; other site 264198000791 eyelet of channel; other site 264198000792 hypothetical protein; Provisional; Region: PRK08244 264198000793 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198000794 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198000795 hypothetical protein; Provisional; Region: PRK08204 264198000796 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198000797 active site 264198000798 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198000799 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198000800 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 264198000801 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 264198000802 N-terminal domain of MhqB, a type I extradiol dioxygenase, and similar proteins; Region: MhqB_like_N; cd08344 264198000803 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198000804 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 264198000805 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198000806 active site 264198000807 metal binding site [ion binding]; metal-binding site 264198000808 Fasciclin domain; Region: Fasciclin; cl02663 264198000809 Fasciclin domain; Region: Fasciclin; cl02663 264198000810 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 264198000811 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 264198000812 DNA binding residues [nucleotide binding] 264198000813 B12 binding domain; Region: B12-binding_2; cl03653 264198000814 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264198000815 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 264198000816 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198000817 dimer interface [polypeptide binding]; other site 264198000818 putative CheW interface [polypeptide binding]; other site 264198000819 Integrase core domain; Region: rve; cl01316 264198000820 Integrase core domain; Region: rve_3; cl15866 264198000821 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 264198000822 Integrase core domain; Region: rve; cl01316 264198000823 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 264198000824 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198000825 AAA domain; Region: AAA_22; pfam13401 264198000826 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198000827 Helix-turn-helix domains; Region: HTH; cl00088 264198000828 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 264198000829 putative dimerization interface [polypeptide binding]; other site 264198000830 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 264198000831 active site 264198000832 catalytic residues [active] 264198000833 metal binding site [ion binding]; metal-binding site 264198000834 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198000835 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198000836 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198000837 NMT1-like family; Region: NMT1_2; cl15260 264198000838 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 264198000839 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 264198000840 trimer interface [polypeptide binding]; other site 264198000841 putative metal binding site [ion binding]; other site 264198000842 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198000843 trimer interface [polypeptide binding]; other site 264198000844 eyelet of channel; other site 264198000845 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 264198000846 metal binding site [ion binding]; metal-binding site 264198000847 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 264198000848 Helix-turn-helix domains; Region: HTH; cl00088 264198000849 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 264198000850 putative dimerization interface [polypeptide binding]; other site 264198000851 enoyl-CoA hydratase; Provisional; Region: PRK06127 264198000852 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198000853 substrate binding site [chemical binding]; other site 264198000854 oxyanion hole (OAH) forming residues; other site 264198000855 trimer interface [polypeptide binding]; other site 264198000856 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198000857 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198000858 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198000859 NMT1-like family; Region: NMT1_2; cl15260 264198000860 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 264198000861 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 264198000862 phosphate binding site [ion binding]; other site 264198000863 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198000864 AAA domain; Region: AAA_22; pfam13401 264198000865 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198000866 Helix-turn-helix domains; Region: HTH; cl00088 264198000867 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198000868 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 264198000869 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 264198000870 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 264198000871 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 264198000872 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198000873 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 264198000874 putative ligand binding site [chemical binding]; other site 264198000875 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198000876 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 264198000877 Walker A/P-loop; other site 264198000878 ATP binding site [chemical binding]; other site 264198000879 Q-loop/lid; other site 264198000880 ABC transporter signature motif; other site 264198000881 Walker B; other site 264198000882 D-loop; other site 264198000883 H-loop/switch region; other site 264198000884 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264198000885 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 264198000886 Walker A/P-loop; other site 264198000887 ATP binding site [chemical binding]; other site 264198000888 Q-loop/lid; other site 264198000889 ABC transporter signature motif; other site 264198000890 Walker B; other site 264198000891 D-loop; other site 264198000892 H-loop/switch region; other site 264198000893 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198000894 TM-ABC transporter signature motif; other site 264198000895 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198000896 TM-ABC transporter signature motif; other site 264198000897 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198000898 FAD dependent oxidoreductase; Region: DAO; pfam01266 264198000899 Cupin domain; Region: Cupin_2; cl09118 264198000900 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198000901 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 264198000902 tetramerization interface [polypeptide binding]; other site 264198000903 NAD(P) binding site [chemical binding]; other site 264198000904 catalytic residues [active] 264198000905 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198000906 Helix-turn-helix domains; Region: HTH; cl00088 264198000907 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264198000908 dimerization interface [polypeptide binding]; other site 264198000909 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 264198000910 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264198000911 inhibitor-cofactor binding pocket; inhibition site 264198000912 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198000913 catalytic residue [active] 264198000914 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198000915 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198000916 NAD(P) binding site [chemical binding]; other site 264198000917 active site 264198000918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198000919 NMT1-like family; Region: NMT1_2; cl15260 264198000920 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264198000921 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 264198000922 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198000923 3-hydroxybutyryl-CoA dehydrogenase; Region: PLN02545 264198000924 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198000925 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 264198000926 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198000927 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198000928 NAD(P) binding site [chemical binding]; other site 264198000929 active site 264198000930 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198000931 Helix-turn-helix domains; Region: HTH; cl00088 264198000932 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198000933 NMT1-like family; Region: NMT1_2; cl15260 264198000934 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198000935 Helix-turn-helix domains; Region: HTH; cl00088 264198000936 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198000937 substrate binding site [chemical binding]; other site 264198000938 oxyanion hole (OAH) forming residues; other site 264198000939 trimer interface [polypeptide binding]; other site 264198000940 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 264198000941 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 264198000942 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 264198000943 Protein export membrane protein; Region: SecD_SecF; cl14618 264198000944 DDE superfamily endonuclease; Region: DDE_4; cl15789 264198000945 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198000946 NMT1-like family; Region: NMT1_2; cl15260 264198000947 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198000948 Helix-turn-helix domains; Region: HTH; cl00088 264198000949 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198000950 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 264198000951 active site 264198000952 oxalacetate binding site [chemical binding]; other site 264198000953 citrylCoA binding site [chemical binding]; other site 264198000954 coenzyme A binding site [chemical binding]; other site 264198000955 catalytic triad [active] 264198000956 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 264198000957 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 264198000958 active site 264198000959 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 264198000960 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198000961 NAD(P) binding site [chemical binding]; other site 264198000962 active site 264198000963 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198000964 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198000965 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198000966 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198000967 active site 264198000968 enoyl-CoA hydratase; Provisional; Region: PRK06688 264198000969 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198000970 substrate binding site [chemical binding]; other site 264198000971 oxyanion hole (OAH) forming residues; other site 264198000972 trimer interface [polypeptide binding]; other site 264198000973 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198000974 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198000975 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 264198000976 putative FMN binding site [chemical binding]; other site 264198000977 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198000978 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198000979 active site 264198000980 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 264198000981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198000982 putative substrate translocation pore; other site 264198000983 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198000984 trimer interface [polypeptide binding]; other site 264198000985 eyelet of channel; other site 264198000986 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 264198000987 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198000988 NMT1-like family; Region: NMT1_2; cl15260 264198000989 Flavin Reductases; Region: FlaRed; cl00801 264198000990 Flavin Reductases; Region: FlaRed; cl00801 264198000991 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 264198000992 NMT1-like family; Region: NMT1_2; cl15260 264198000993 Cupin domain; Region: Cupin_2; cl09118 264198000994 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 264198000995 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 264198000996 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 264198000997 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 264198000998 classical (c) SDRs; Region: SDR_c; cd05233 264198000999 NAD(P) binding site [chemical binding]; other site 264198001000 active site 264198001001 Dienelactone hydrolase family; Region: DLH; pfam01738 264198001002 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198001003 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198001004 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 264198001005 active site 264198001006 oxalacetate binding site [chemical binding]; other site 264198001007 citrylCoA binding site [chemical binding]; other site 264198001008 coenzyme A binding site [chemical binding]; other site 264198001009 catalytic triad [active] 264198001010 Cache domain; Region: Cache_1; pfam02743 264198001011 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264198001012 dimerization interface [polypeptide binding]; other site 264198001013 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198001014 dimer interface [polypeptide binding]; other site 264198001015 putative CheW interface [polypeptide binding]; other site 264198001016 Transcriptional regulators [Transcription]; Region: MarR; COG1846 264198001017 Helix-turn-helix domains; Region: HTH; cl00088 264198001018 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 264198001019 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 264198001020 NAD(P) binding site [chemical binding]; other site 264198001021 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 264198001022 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198001023 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 264198001024 [2Fe-2S] cluster binding site [ion binding]; other site 264198001025 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 264198001026 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 264198001027 hydrophobic ligand binding site; other site 264198001028 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198001029 NAD(P) binding site [chemical binding]; other site 264198001030 active site 264198001031 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264198001032 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 264198001033 Walker A/P-loop; other site 264198001034 ATP binding site [chemical binding]; other site 264198001035 Q-loop/lid; other site 264198001036 ABC transporter signature motif; other site 264198001037 Walker B; other site 264198001038 D-loop; other site 264198001039 H-loop/switch region; other site 264198001040 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198001041 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 264198001042 Walker A/P-loop; other site 264198001043 ATP binding site [chemical binding]; other site 264198001044 Q-loop/lid; other site 264198001045 ABC transporter signature motif; other site 264198001046 Walker B; other site 264198001047 D-loop; other site 264198001048 H-loop/switch region; other site 264198001049 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198001050 TM-ABC transporter signature motif; other site 264198001051 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198001052 TM-ABC transporter signature motif; other site 264198001053 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198001054 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 264198001055 putative ligand binding site [chemical binding]; other site 264198001056 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264198001057 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 264198001058 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264198001059 catalytic residue [active] 264198001060 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198001061 trimer interface [polypeptide binding]; other site 264198001062 eyelet of channel; other site 264198001063 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 264198001064 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 264198001065 Cupin domain; Region: Cupin_2; cl09118 264198001066 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 264198001067 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198001068 TfoX N-terminal domain; Region: TfoX_N; cl01167 264198001069 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 264198001070 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 264198001071 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 264198001072 Integrase core domain; Region: rve; cl01316 264198001073 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 264198001074 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 264198001075 Helix-turn-helix domains; Region: HTH; cl00088 264198001076 amidase; Provisional; Region: PRK07056 264198001077 Amidase; Region: Amidase; cl11426 264198001078 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 264198001079 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 264198001080 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 264198001081 putative active site [active] 264198001082 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 264198001083 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 264198001084 H-NS histone family; Region: Histone_HNS; pfam00816 264198001085 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 264198001086 H-NS histone family; Region: Histone_HNS; pfam00816 264198001087 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 264198001088 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 264198001089 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 264198001090 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 264198001091 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 264198001092 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 264198001093 dimer interaction site [polypeptide binding]; other site 264198001094 substrate-binding tunnel; other site 264198001095 active site 264198001096 catalytic site [active] 264198001097 substrate binding site [chemical binding]; other site 264198001098 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 264198001099 dimer interface [polypeptide binding]; other site 264198001100 Citrate synthase; Region: Citrate_synt; pfam00285 264198001101 active site 264198001102 citrylCoA binding site [chemical binding]; other site 264198001103 NADH binding [chemical binding]; other site 264198001104 cationic pore residues; other site 264198001105 oxalacetate/citrate binding site [chemical binding]; other site 264198001106 coenzyme A binding site [chemical binding]; other site 264198001107 catalytic triad [active] 264198001108 citrate-proton symporter; Provisional; Region: PRK15075 264198001109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198001110 putative substrate translocation pore; other site 264198001111 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 264198001112 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 264198001113 dimer interface [polypeptide binding]; other site 264198001114 PYR/PP interface [polypeptide binding]; other site 264198001115 TPP binding site [chemical binding]; other site 264198001116 substrate binding site [chemical binding]; other site 264198001117 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 264198001118 TPP-binding site [chemical binding]; other site 264198001119 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 264198001120 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 264198001121 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 264198001122 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 264198001123 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 264198001124 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198001125 DNA-binding site [nucleotide binding]; DNA binding site 264198001126 UTRA domain; Region: UTRA; cl01230 264198001127 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 264198001128 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 264198001129 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 264198001130 NAD(P) binding site [chemical binding]; other site 264198001131 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 264198001132 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 264198001133 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 264198001134 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 264198001135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198001136 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 264198001137 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 264198001138 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 264198001139 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198001140 classical (c) SDRs; Region: SDR_c; cd05233 264198001141 NAD(P) binding site [chemical binding]; other site 264198001142 active site 264198001143 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198001144 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198001145 active site 264198001146 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 264198001147 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 264198001148 putative active site [active] 264198001149 putative substrate binding site [chemical binding]; other site 264198001150 ATP binding site [chemical binding]; other site 264198001151 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 264198001152 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 264198001153 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198001154 active site 264198001155 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 264198001156 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 264198001157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198001158 LDH/MDH dimer interface [polypeptide binding]; other site 264198001159 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 264198001160 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198001161 Helix-turn-helix domains; Region: HTH; cl00088 264198001162 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198001163 dimerization interface [polypeptide binding]; other site 264198001164 Protein of unknown function (DUF3422); Region: DUF3422; cl02073 264198001165 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198001166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198001167 putative substrate translocation pore; other site 264198001168 choline dehydrogenase; Validated; Region: PRK02106 264198001169 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198001170 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 264198001171 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198001172 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 264198001173 NAD(P) binding site [chemical binding]; other site 264198001174 catalytic residues [active] 264198001175 Helix-turn-helix domains; Region: HTH; cl00088 264198001176 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 264198001177 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 264198001178 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 264198001179 Integrase core domain; Region: rve; cl01316 264198001180 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 264198001181 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 264198001182 H-NS histone family; Region: Histone_HNS; pfam00816 264198001183 H-NS histone family; Region: Histone_HNS; pfam00816 264198001184 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 264198001185 Dienelactone hydrolase family; Region: DLH; pfam01738 264198001186 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198001187 Helix-turn-helix domains; Region: HTH; cl00088 264198001188 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198001189 Helix-turn-helix domains; Region: HTH; cl00088 264198001190 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 264198001191 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 264198001192 homotrimer interaction site [polypeptide binding]; other site 264198001193 putative active site [active] 264198001194 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 264198001195 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 264198001196 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 264198001197 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 264198001198 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198001199 NAD(P) binding site [chemical binding]; other site 264198001200 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 264198001201 AMP-binding enzyme; Region: AMP-binding; cl15778 264198001202 AMP-binding enzyme; Region: AMP-binding; cl15778 264198001203 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 264198001204 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 264198001205 active site 264198001206 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198001207 FAD dependent oxidoreductase; Region: DAO; pfam01266 264198001208 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 264198001209 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198001210 FAD dependent oxidoreductase; Region: DAO; pfam01266 264198001211 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198001212 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198001213 active site 264198001214 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 264198001215 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198001216 Cytochrome c; Region: Cytochrom_C; cl11414 264198001217 Cytochrome c; Region: Cytochrom_C; cl11414 264198001218 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198001219 classical (c) SDRs; Region: SDR_c; cd05233 264198001220 NAD(P) binding site [chemical binding]; other site 264198001221 active site 264198001222 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198001223 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 264198001224 homotetramer interface [polypeptide binding]; other site 264198001225 NAD(P) binding site [chemical binding]; other site 264198001226 homodimer interface [polypeptide binding]; other site 264198001227 active site 264198001228 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 264198001229 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 264198001230 putative active site [active] 264198001231 putative substrate binding site [chemical binding]; other site 264198001232 ATP binding site [chemical binding]; other site 264198001233 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 264198001234 classical (c) SDRs; Region: SDR_c; cd05233 264198001235 NAD(P) binding site [chemical binding]; other site 264198001236 active site 264198001237 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 264198001238 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 264198001239 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198001240 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 264198001241 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 264198001242 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 264198001243 Peptidase family M23; Region: Peptidase_M23; pfam01551 264198001244 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198001245 PAS domain; Region: PAS_9; pfam13426 264198001246 putative active site [active] 264198001247 heme pocket [chemical binding]; other site 264198001248 DDE superfamily endonuclease; Region: DDE_4; cl15789 264198001249 DDE superfamily endonuclease; Region: DDE_4; cl15789 264198001250 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198001251 dimer interface [polypeptide binding]; other site 264198001252 phosphorylation site [posttranslational modification] 264198001253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198001254 ATP binding site [chemical binding]; other site 264198001255 Mg2+ binding site [ion binding]; other site 264198001256 G-X-G motif; other site 264198001257 Response regulator receiver domain; Region: Response_reg; pfam00072 264198001258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198001259 active site 264198001260 phosphorylation site [posttranslational modification] 264198001261 intermolecular recognition site; other site 264198001262 dimerization interface [polypeptide binding]; other site 264198001263 Response regulator receiver domain; Region: Response_reg; pfam00072 264198001264 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198001265 active site 264198001266 phosphorylation site [posttranslational modification] 264198001267 intermolecular recognition site; other site 264198001268 dimerization interface [polypeptide binding]; other site 264198001269 Heme NO binding associated; Region: HNOBA; pfam07701 264198001270 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 264198001271 cyclase homology domain; Region: CHD; cd07302 264198001272 nucleotidyl binding site; other site 264198001273 metal binding site [ion binding]; metal-binding site 264198001274 dimer interface [polypeptide binding]; other site 264198001275 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 264198001276 Transposase; Region: DDE_Tnp_ISL3; pfam01610 264198001277 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198001278 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 264198001279 Walker A motif; other site 264198001280 ATP binding site [chemical binding]; other site 264198001281 Walker B motif; other site 264198001282 arginine finger; other site 264198001283 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 264198001284 Helix-turn-helix domains; Region: HTH; cl00088 264198001285 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 264198001286 active site 264198001287 catalytic triad [active] 264198001288 Zeta toxin; Region: Zeta_toxin; pfam06414 264198001289 acyl-CoA synthetase; Validated; Region: PRK08162 264198001290 AMP-binding enzyme; Region: AMP-binding; cl15778 264198001291 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198001292 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198001293 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198001294 active site 264198001295 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 264198001296 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 264198001297 putative active site [active] 264198001298 metal binding site [ion binding]; metal-binding site 264198001299 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 264198001300 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 264198001301 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 264198001302 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 264198001303 dimer interaction site [polypeptide binding]; other site 264198001304 substrate-binding tunnel; other site 264198001305 active site 264198001306 catalytic site [active] 264198001307 substrate binding site [chemical binding]; other site 264198001308 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 264198001309 Helix-turn-helix domains; Region: HTH; cl00088 264198001310 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 264198001311 dimerization interface [polypeptide binding]; other site 264198001312 substrate binding pocket [chemical binding]; other site 264198001313 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 264198001314 dimer interface [polypeptide binding]; other site 264198001315 NADP binding site [chemical binding]; other site 264198001316 catalytic residues [active] 264198001317 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198001318 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 264198001319 putative ligand binding site [chemical binding]; other site 264198001320 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198001321 TM-ABC transporter signature motif; other site 264198001322 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198001323 TM-ABC transporter signature motif; other site 264198001324 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 264198001325 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 264198001326 Walker A/P-loop; other site 264198001327 ATP binding site [chemical binding]; other site 264198001328 Q-loop/lid; other site 264198001329 ABC transporter signature motif; other site 264198001330 Walker B; other site 264198001331 D-loop; other site 264198001332 H-loop/switch region; other site 264198001333 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198001334 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 264198001335 Walker A/P-loop; other site 264198001336 ATP binding site [chemical binding]; other site 264198001337 Q-loop/lid; other site 264198001338 ABC transporter signature motif; other site 264198001339 Walker B; other site 264198001340 D-loop; other site 264198001341 H-loop/switch region; other site 264198001342 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 264198001343 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 264198001344 XdhC Rossmann domain; Region: XdhC_C; pfam13478 264198001345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198001346 putative substrate translocation pore; other site 264198001347 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 264198001348 ParB-like partition proteins; Region: parB_part; TIGR00180 264198001349 ParB-like nuclease domain; Region: ParBc; cl02129 264198001350 KorB domain; Region: KorB; pfam08535 264198001351 KorB C-terminal beta-barrel domain; Region: KorB_C; pfam06613 264198001352 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 264198001353 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264198001354 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 264198001355 P-loop; other site 264198001356 Magnesium ion binding site [ion binding]; other site 264198001357 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264198001358 Magnesium ion binding site [ion binding]; other site 264198001359 Protein of unknown function (DUF2761); Region: DUF2761; pfam10959 264198001360 Antirestriction protein; Region: Antirestrict; pfam03230 264198001361 RelB antitoxin; Region: RelB; cl01171 264198001362 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 264198001363 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 264198001364 Phage integrase protein; Region: DUF3701; pfam12482 264198001365 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 264198001366 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 264198001367 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 264198001368 Int/Topo IB signature motif; other site 264198001369 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 264198001370 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 264198001371 FAD binding domain; Region: FAD_binding_3; pfam01494 264198001372 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 264198001373 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 264198001374 active site 264198001375 dimer interface [polypeptide binding]; other site 264198001376 metal binding site [ion binding]; metal-binding site 264198001377 Dienelactone hydrolase family; Region: DLH; pfam01738 264198001378 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 264198001379 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 264198001380 octamer interface [polypeptide binding]; other site 264198001381 active site 264198001382 chlorocatechol 1,2-dioxygenases (1,2-CCDs) (type II enzymes) are homodimeric intradiol dioxygenases that degrade chlorocatechols via the addition of molecular oxygen and the subsequent cleavage between two adjacent hydroxyl groups. This reaction is part...; Region: 1,2-CCD; cd03462 264198001383 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 264198001384 dimer interface [polypeptide binding]; other site 264198001385 active site 264198001386 Helix-turn-helix domains; Region: HTH; cl00088 264198001387 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198001388 dimerization interface [polypeptide binding]; other site 264198001389 DDE superfamily endonuclease; Region: DDE_4; cl15789 264198001390 DDE superfamily endonuclease; Region: DDE_4; cl15789 264198001391 benzoate transport; Region: 2A0115; TIGR00895 264198001392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198001393 putative substrate translocation pore; other site 264198001394 FAD binding domain; Region: FAD_binding_3; pfam01494 264198001395 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198001396 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 264198001397 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 264198001398 active site 264198001399 dimer interface [polypeptide binding]; other site 264198001400 metal binding site [ion binding]; metal-binding site 264198001401 Dienelactone hydrolase family; Region: DLH; pfam01738 264198001402 chlorocatechol 1,2-dioxygenases (1,2-CCDs) (type II enzymes) are homodimeric intradiol dioxygenases that degrade chlorocatechols via the addition of molecular oxygen and the subsequent cleavage between two adjacent hydroxyl groups. This reaction is part...; Region: 1,2-CCD; cd03462 264198001403 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 264198001404 dimer interface [polypeptide binding]; other site 264198001405 active site 264198001406 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 264198001407 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 264198001408 octamer interface [polypeptide binding]; other site 264198001409 active site 264198001410 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198001411 Helix-turn-helix domains; Region: HTH; cl00088 264198001412 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the chlorocatechol catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_Chlorocatechol; cd08446 264198001413 dimerization interface [polypeptide binding]; other site 264198001414 putative substrate binding pocket [chemical binding]; other site 264198001415 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 264198001416 Helix-turn-helix domains; Region: HTH; cl00088 264198001417 enoyl-CoA hydratase; Provisional; Region: PRK06127 264198001418 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198001419 substrate binding site [chemical binding]; other site 264198001420 oxyanion hole (OAH) forming residues; other site 264198001421 trimer interface [polypeptide binding]; other site 264198001422 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 264198001423 Helix-turn-helix domains; Region: HTH; cl00088 264198001424 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198001425 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198001426 Helix-turn-helix domains; Region: HTH; cl00088 264198001427 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the chlorocatechol catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_Chlorocatechol; cd08446 264198001428 dimerization interface [polypeptide binding]; other site 264198001429 putative substrate binding pocket [chemical binding]; other site 264198001430 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 264198001431 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 264198001432 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12406 264198001433 AMP-binding enzyme; Region: AMP-binding; cl15778 264198001434 AMP-binding enzyme; Region: AMP-binding; cl15778 264198001435 thiolase; Provisional; Region: PRK06158 264198001436 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 264198001437 active site 264198001438 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 264198001439 DUF35 OB-fold domain; Region: DUF35; pfam01796 264198001440 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 264198001441 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 264198001442 iron-sulfur cluster [ion binding]; other site 264198001443 [2Fe-2S] cluster binding site [ion binding]; other site 264198001444 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 264198001445 hydrophobic ligand binding site; other site 264198001446 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198001447 Helix-turn-helix domains; Region: HTH; cl00088 264198001448 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198001449 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198001450 Helix-turn-helix domains; Region: HTH; cl00088 264198001451 sorbitol dehydrogenase; Provisional; Region: PRK07067 264198001452 classical (c) SDRs; Region: SDR_c; cd05233 264198001453 NAD(P) binding site [chemical binding]; other site 264198001454 active site 264198001455 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198001456 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330 264198001457 putative ligand binding site [chemical binding]; other site 264198001458 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198001459 TM-ABC transporter signature motif; other site 264198001460 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198001461 TM-ABC transporter signature motif; other site 264198001462 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198001463 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 264198001464 Walker A/P-loop; other site 264198001465 ATP binding site [chemical binding]; other site 264198001466 Q-loop/lid; other site 264198001467 ABC transporter signature motif; other site 264198001468 Walker B; other site 264198001469 D-loop; other site 264198001470 H-loop/switch region; other site 264198001471 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 264198001472 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 264198001473 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264198001474 MerE protein; Region: MerE; cl04911 264198001475 transcriptional regulator MerD; Provisional; Region: PRK13749 264198001476 Helix-Turn-Helix DNA binding domain of the MerD transcription regulator; Region: HTH_MerD; cd01111 264198001477 DNA binding residues [nucleotide binding] 264198001478 putative dimer interface [polypeptide binding]; other site 264198001479 putative mercuric reductase; Provisional; Region: PRK13748 264198001480 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 264198001481 metal-binding site [ion binding] 264198001482 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198001483 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 264198001484 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 264198001485 metal-binding site [ion binding] 264198001486 MerT mercuric transport protein; Region: MerT; cl03578 264198001487 putative transcriptional regulator MerR; Provisional; Region: PRK13752 264198001488 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 264198001489 DNA binding residues [nucleotide binding] 264198001490 dimer interface [polypeptide binding]; other site 264198001491 mercury binding site [ion binding]; other site 264198001492 TrfA protein; Region: TrfA; pfam07042 264198001493 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 264198001494 dimer interface [polypeptide binding]; other site 264198001495 ssDNA binding site [nucleotide binding]; other site 264198001496 tetramer (dimer of dimers) interface [polypeptide binding]; other site 264198001497 conjugal transfer protein TrbA; Provisional; Region: PRK13890 264198001498 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264198001499 salt bridge; other site 264198001500 non-specific DNA binding site [nucleotide binding]; other site 264198001501 sequence-specific DNA binding site [nucleotide binding]; other site 264198001502 conjugal transfer ATPase TrbB; Provisional; Region: PRK13894 264198001503 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 264198001504 ATP binding site [chemical binding]; other site 264198001505 Walker A motif; other site 264198001506 hexamer interface [polypeptide binding]; other site 264198001507 Walker B motif; other site 264198001508 TrbC/VIRB2 family; Region: TrbC; cl01583 264198001509 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 264198001510 conjugal transfer protein TrbE; Provisional; Region: PRK13891 264198001511 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 264198001512 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198001513 Walker B; other site 264198001514 D-loop; other site 264198001515 H-loop/switch region; other site 264198001516 VirB8 protein; Region: VirB8; cl01500 264198001517 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 264198001518 VirB7 interaction site; other site 264198001519 conjugal transfer protein TrbH; Provisional; Region: PRK13883 264198001520 Conjugal transfer protein TrbH; Region: TrbH; pfam07283 264198001521 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 264198001522 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314; cl02193 264198001523 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 264198001524 TrbM; Region: TrbM; cl06455 264198001525 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 264198001526 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264198001527 catalytic residue [active] 264198001528 conjugal transfer protein TrbP; Provisional; Region: PRK13882 264198001529 TraX protein; Region: TraX; cl05434 264198001530 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 264198001531 ligand binding site [chemical binding]; other site 264198001532 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 264198001533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 264198001534 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 264198001535 catalytic residues [active] 264198001536 catalytic nucleophile [active] 264198001537 Helix-turn-helix domains; Region: HTH; cl00088 264198001538 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 264198001539 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 264198001540 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 264198001541 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 264198001542 active site 264198001543 metal binding site [ion binding]; metal-binding site 264198001544 interdomain interaction site; other site 264198001545 DNA topoisomerase III; Provisional; Region: PRK07726 264198001546 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 264198001547 active site 264198001548 putative interdomain interaction site [polypeptide binding]; other site 264198001549 putative metal-binding site [ion binding]; other site 264198001550 putative nucleotide binding site [chemical binding]; other site 264198001551 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 264198001552 domain I; other site 264198001553 DNA binding groove [nucleotide binding] 264198001554 phosphate binding site [ion binding]; other site 264198001555 domain II; other site 264198001556 domain III; other site 264198001557 nucleotide binding site [chemical binding]; other site 264198001558 catalytic site [active] 264198001559 domain IV; other site 264198001560 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 264198001561 conjugal transfer peptidase TraF; Provisional; Region: PRK13884 264198001562 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 264198001563 conjugal transfer coupling protein TraG; Provisional; Region: PRK13880 264198001564 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198001565 Walker A motif; other site 264198001566 ATP binding site [chemical binding]; other site 264198001567 Walker B motif; other site 264198001568 conjugal transfer relaxase TraI; Provisional; Region: PRK13878 264198001569 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584 264198001570 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 264198001571 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 264198001572 P-loop; other site 264198001573 Transcriptional activator TraM; Region: Activator-TraM; cl11943 264198001574 DnaA N-terminal domain; Region: DnaA_N; pfam11638 264198001575 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 264198001576 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198001577 Walker A motif; other site 264198001578 ATP binding site [chemical binding]; other site 264198001579 Walker B motif; other site 264198001580 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198001581 arginine finger; other site 264198001582 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 264198001583 DnaA box-binding interface [nucleotide binding]; other site 264198001584 DNA polymerase III subunit beta; Validated; Region: PRK05643 264198001585 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 264198001586 putative DNA binding surface [nucleotide binding]; other site 264198001587 dimer interface [polypeptide binding]; other site 264198001588 beta-clamp/clamp loader binding surface; other site 264198001589 beta-clamp/translesion DNA polymerase binding surface; other site 264198001590 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit [DNA replication, recombination, and repair]; Region: GyrB; COG0187 264198001591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198001592 ATP binding site [chemical binding]; other site 264198001593 Mg2+ binding site [ion binding]; other site 264198001594 G-X-G motif; other site 264198001595 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 264198001596 anchoring element; other site 264198001597 dimer interface [polypeptide binding]; other site 264198001598 ATP binding site [chemical binding]; other site 264198001599 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 264198001600 active site 264198001601 putative metal-binding site [ion binding]; other site 264198001602 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 264198001603 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 264198001604 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 264198001605 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 264198001606 putative active site [active] 264198001607 putative NTP binding site [chemical binding]; other site 264198001608 putative nucleic acid binding site [nucleotide binding]; other site 264198001609 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 264198001610 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 264198001611 Protein of unknown function (DUF1484); Region: DUF1484; pfam07363 264198001612 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 264198001613 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 264198001614 active site 264198001615 catalytic tetrad [active] 264198001616 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198001617 Helix-turn-helix domains; Region: HTH; cl00088 264198001618 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 264198001619 putative effector binding pocket; other site 264198001620 putative dimerization interface [polypeptide binding]; other site 264198001621 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 264198001622 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 264198001623 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 264198001624 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 264198001625 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 264198001626 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 264198001627 PAAR motif; Region: PAAR_motif; cl15808 264198001628 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 264198001629 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 264198001630 FOG: CBS domain [General function prediction only]; Region: COG0517 264198001631 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 264198001632 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 264198001633 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198001634 PAS domain; Region: PAS_9; pfam13426 264198001635 putative active site [active] 264198001636 heme pocket [chemical binding]; other site 264198001637 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198001638 metal binding site [ion binding]; metal-binding site 264198001639 active site 264198001640 I-site; other site 264198001641 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264198001642 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 264198001643 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 264198001644 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 264198001645 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 264198001646 putative active site [active] 264198001647 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264198001648 ligand binding site [chemical binding]; other site 264198001649 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 264198001650 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 264198001651 potential catalytic triad [active] 264198001652 conserved cys residue [active] 264198001653 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 264198001654 Helix-turn-helix domains; Region: HTH; cl00088 264198001655 Phospholipid methyltransferase; Region: PEMT; cl00763 264198001656 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 264198001657 homodimer interface [polypeptide binding]; other site 264198001658 chemical substrate binding site [chemical binding]; other site 264198001659 oligomer interface [polypeptide binding]; other site 264198001660 metal binding site [ion binding]; metal-binding site 264198001661 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 264198001662 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 264198001663 active site 264198001664 zinc binding site [ion binding]; other site 264198001665 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 264198001666 active site 264198001667 homotetramer interface [polypeptide binding]; other site 264198001668 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 264198001669 active site 264198001670 homotetramer interface [polypeptide binding]; other site 264198001671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198001672 D-galactonate transporter; Region: 2A0114; TIGR00893 264198001673 putative substrate translocation pore; other site 264198001674 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198001675 Helix-turn-helix domains; Region: HTH; cl00088 264198001676 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198001677 dimerization interface [polypeptide binding]; other site 264198001678 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 264198001679 Cache domain; Region: Cache_1; pfam02743 264198001680 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264198001681 dimerization interface [polypeptide binding]; other site 264198001682 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198001683 dimer interface [polypeptide binding]; other site 264198001684 putative CheW interface [polypeptide binding]; other site 264198001685 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 264198001686 Protein of unknown function DUF72; Region: DUF72; cl00777 264198001687 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 264198001688 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 264198001689 ATP binding site [chemical binding]; other site 264198001690 Mg++ binding site [ion binding]; other site 264198001691 motif III; other site 264198001692 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264198001693 nucleotide binding region [chemical binding]; other site 264198001694 ATP-binding site [chemical binding]; other site 264198001695 DbpA RNA binding domain; Region: DbpA; pfam03880 264198001696 FOG: CBS domain [General function prediction only]; Region: COG0517 264198001697 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 264198001698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198001699 putative substrate translocation pore; other site 264198001700 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 264198001701 catalytic residues [active] 264198001702 dimer interface [polypeptide binding]; other site 264198001703 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264198001704 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 264198001705 dihydropyrimidinase; Provisional; Region: PRK13404 264198001706 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 264198001707 tetramer interface [polypeptide binding]; other site 264198001708 active site 264198001709 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 264198001710 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 264198001711 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 264198001712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198001713 D-galactonate transporter; Region: 2A0114; TIGR00893 264198001714 putative substrate translocation pore; other site 264198001715 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264198001716 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198001717 DNA-binding site [nucleotide binding]; DNA binding site 264198001718 FCD domain; Region: FCD; cl11656 264198001719 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 264198001720 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 264198001721 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 264198001722 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 264198001723 metal binding site [ion binding]; metal-binding site 264198001724 putative dimer interface [polypeptide binding]; other site 264198001725 Cupin domain; Region: Cupin_2; cl09118 264198001726 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198001727 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198001728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198001729 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198001730 putative substrate translocation pore; other site 264198001731 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 264198001732 GAF domain; Region: GAF_2; pfam13185 264198001733 GAF domain; Region: GAF; cl15785 264198001734 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 264198001735 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198001736 NMT1-like family; Region: NMT1_2; cl15260 264198001737 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264198001738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198001739 active site 264198001740 phosphorylation site [posttranslational modification] 264198001741 intermolecular recognition site; other site 264198001742 dimerization interface [polypeptide binding]; other site 264198001743 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198001744 DNA binding site [nucleotide binding] 264198001745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264198001746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198001747 active site 264198001748 phosphorylation site [posttranslational modification] 264198001749 intermolecular recognition site; other site 264198001750 dimerization interface [polypeptide binding]; other site 264198001751 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198001752 DNA binding site [nucleotide binding] 264198001753 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198001754 trimer interface [polypeptide binding]; other site 264198001755 eyelet of channel; other site 264198001756 Septum formation topological specificity factor MinE; Region: MinE; cl00538 264198001757 cell division inhibitor MinD; Provisional; Region: PRK10818 264198001758 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 264198001759 Switch I; other site 264198001760 Switch II; other site 264198001761 septum formation inhibitor; Reviewed; Region: PRK01973 264198001762 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 264198001763 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 264198001764 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 264198001765 Sel1 repeat; Region: Sel1; cl02723 264198001766 Sel1 repeat; Region: Sel1; cl02723 264198001767 Sel1 repeat; Region: Sel1; cl02723 264198001768 Sel1 repeat; Region: Sel1; cl02723 264198001769 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 264198001770 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 264198001771 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 264198001772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 264198001773 Uncharacterized conserved protein [Function unknown]; Region: COG2308 264198001774 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 264198001775 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 264198001776 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 264198001777 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 264198001778 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 264198001779 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 264198001780 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 264198001781 GatB domain; Region: GatB_Yqey; cl11497 264198001782 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198001783 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 264198001784 Amidase; Region: Amidase; cl11426 264198001785 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 264198001786 rod shape-determining protein MreB; Provisional; Region: PRK13927 264198001787 Cell division protein FtsA; Region: FtsA; cl11496 264198001788 rod shape-determining protein MreC; Region: MreC; pfam04085 264198001789 rod shape-determining protein MreD; Region: MreD; cl01087 264198001790 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 264198001791 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 264198001792 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 264198001793 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 264198001794 GAF domain; Region: GAF; cl15785 264198001795 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 264198001796 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264198001797 active site 264198001798 DNA binding site [nucleotide binding] 264198001799 Int/Topo IB signature motif; other site 264198001800 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 264198001801 Helix-turn-helix domains; Region: HTH; cl00088 264198001802 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 264198001803 dimerization interface [polypeptide binding]; other site 264198001804 substrate binding pocket [chemical binding]; other site 264198001805 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 264198001806 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 264198001807 lipoyl synthase; Provisional; Region: PRK05481 264198001808 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264198001809 FeS/SAM binding site; other site 264198001810 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 264198001811 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 264198001812 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 264198001813 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 264198001814 putative active site [active] 264198001815 Protein of unknown function (DUF969); Region: DUF969; cl01573 264198001816 Protein of unknown function (DUF979); Region: DUF979; cl01572 264198001817 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 264198001818 putative substrate binding pocket [chemical binding]; other site 264198001819 AC domain interface; other site 264198001820 catalytic triad [active] 264198001821 AB domain interface; other site 264198001822 interchain disulfide; other site 264198001823 haemagglutination activity domain; Region: Haemagg_act; cl05436 264198001824 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 264198001825 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 264198001826 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 264198001827 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 264198001828 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 264198001829 Surface antigen; Region: Bac_surface_Ag; cl03097 264198001830 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 264198001831 CAAX protease self-immunity; Region: Abi; cl00558 264198001832 VanZ like family; Region: VanZ; cl01971 264198001833 Protein of unknown function (DUF330); Region: DUF330; cl01135 264198001834 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 264198001835 mce related protein; Region: MCE; pfam02470 264198001836 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 264198001837 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 264198001838 Walker A/P-loop; other site 264198001839 ATP binding site [chemical binding]; other site 264198001840 Q-loop/lid; other site 264198001841 ABC transporter signature motif; other site 264198001842 Walker B; other site 264198001843 D-loop; other site 264198001844 H-loop/switch region; other site 264198001845 Permease; Region: Permease; cl00510 264198001846 biotin--protein ligase; Provisional; Region: PRK06955 264198001847 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 264198001848 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 264198001849 Type III pantothenate kinase; Region: Pan_kinase; cl09130 264198001850 Sporulation related domain; Region: SPOR; cl10051 264198001851 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264198001852 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 264198001853 active site 264198001854 nucleotide binding site [chemical binding]; other site 264198001855 HIGH motif; other site 264198001856 KMSKS motif; other site 264198001857 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198001858 Helix-turn-helix domains; Region: HTH; cl00088 264198001859 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 264198001860 dinuclear metal binding motif [ion binding]; other site 264198001861 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 264198001862 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 264198001863 active site 264198001864 nucleophile elbow; other site 264198001865 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 264198001866 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198001867 substrate binding site [chemical binding]; other site 264198001868 oxyanion hole (OAH) forming residues; other site 264198001869 trimer interface [polypeptide binding]; other site 264198001870 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 264198001871 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198001872 NMT1-like family; Region: NMT1_2; cl15260 264198001873 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198001874 Helix-turn-helix domains; Region: HTH; cl00088 264198001875 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198001876 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 264198001877 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 264198001878 Protein of unknown function (DUF3567); Region: DUF3567; pfam12091 264198001879 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 264198001880 active site residue [active] 264198001881 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 264198001882 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 264198001883 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 264198001884 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 264198001885 substrate binding pocket [chemical binding]; other site 264198001886 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 264198001887 B12 binding site [chemical binding]; other site 264198001888 cobalt ligand [ion binding]; other site 264198001889 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 264198001890 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198001891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198001892 active site 264198001893 phosphorylation site [posttranslational modification] 264198001894 intermolecular recognition site; other site 264198001895 dimerization interface [polypeptide binding]; other site 264198001896 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198001897 DNA binding residues [nucleotide binding] 264198001898 dimerization interface [polypeptide binding]; other site 264198001899 Response regulator receiver domain; Region: Response_reg; pfam00072 264198001900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198001901 active site 264198001902 phosphorylation site [posttranslational modification] 264198001903 intermolecular recognition site; other site 264198001904 dimerization interface [polypeptide binding]; other site 264198001905 CHASE3 domain; Region: CHASE3; cl05000 264198001906 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264198001907 Histidine kinase; Region: HisKA_3; pfam07730 264198001908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198001909 ATP binding site [chemical binding]; other site 264198001910 Mg2+ binding site [ion binding]; other site 264198001911 G-X-G motif; other site 264198001912 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 264198001913 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 264198001914 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 264198001915 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 264198001916 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 264198001917 active site 264198001918 HIGH motif; other site 264198001919 KMSK motif region; other site 264198001920 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 264198001921 tRNA binding surface [nucleotide binding]; other site 264198001922 anticodon binding site; other site 264198001923 Sporulation related domain; Region: SPOR; cl10051 264198001924 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 264198001925 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 264198001926 catalytic residues [active] 264198001927 hinge region; other site 264198001928 alpha helical domain; other site 264198001929 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 264198001930 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198001931 NAD(P) binding site [chemical binding]; other site 264198001932 active site 264198001933 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 264198001934 intersubunit interface [polypeptide binding]; other site 264198001935 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264198001936 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 264198001937 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 264198001938 DNA binding residues [nucleotide binding] 264198001939 putative dimer interface [polypeptide binding]; other site 264198001940 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 264198001941 CoenzymeA binding site [chemical binding]; other site 264198001942 subunit interaction site [polypeptide binding]; other site 264198001943 PHB binding site; other site 264198001944 isovaleryl-CoA dehydrogenase; Region: PLN02519 264198001945 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 264198001946 substrate binding site [chemical binding]; other site 264198001947 FAD binding site [chemical binding]; other site 264198001948 catalytic base [active] 264198001949 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 264198001950 Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; cl01891 264198001951 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 264198001952 active site clefts [active] 264198001953 zinc binding site [ion binding]; other site 264198001954 dimer interface [polypeptide binding]; other site 264198001955 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 264198001956 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264198001957 dimer interface [polypeptide binding]; other site 264198001958 active site 264198001959 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 264198001960 NADP binding site [chemical binding]; other site 264198001961 homodimer interface [polypeptide binding]; other site 264198001962 active site 264198001963 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198001964 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198001965 active site 264198001966 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 264198001967 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 264198001968 putative catalytic residue [active] 264198001969 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 264198001970 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264198001971 motif II; other site 264198001972 hypothetical protein; Provisional; Region: PRK01842 264198001973 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 264198001974 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264198001975 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 264198001976 putative C-terminal domain interface [polypeptide binding]; other site 264198001977 putative GSH binding site (G-site) [chemical binding]; other site 264198001978 putative dimer interface [polypeptide binding]; other site 264198001979 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 264198001980 N-terminal domain interface [polypeptide binding]; other site 264198001981 dimer interface [polypeptide binding]; other site 264198001982 substrate binding pocket (H-site) [chemical binding]; other site 264198001983 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 264198001984 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 264198001985 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 264198001986 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 264198001987 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198001988 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943 264198001989 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264198001990 inhibitor-cofactor binding pocket; inhibition site 264198001991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198001992 catalytic residue [active] 264198001993 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264198001994 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 264198001995 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264198001996 catalytic residue [active] 264198001997 AAA domain; Region: AAA_26; pfam13500 264198001998 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198001999 biotin synthase; Region: bioB; TIGR00433 264198002000 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264198002001 FeS/SAM binding site; other site 264198002002 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 264198002003 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 264198002004 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264198002005 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 264198002006 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264198002007 carboxyltransferase (CT) interaction site; other site 264198002008 biotinylation site [posttranslational modification]; other site 264198002009 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 264198002010 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198002011 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 264198002012 active site 264198002013 catalytic residues [active] 264198002014 metal binding site [ion binding]; metal-binding site 264198002015 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 264198002016 putative deacylase active site [active] 264198002017 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 264198002018 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 264198002019 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264198002020 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264198002021 MULE transposase domain; Region: MULE; pfam10551 264198002022 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 264198002023 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264198002024 N-terminal plug; other site 264198002025 ligand-binding site [chemical binding]; other site 264198002026 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 264198002027 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198002028 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 264198002029 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 264198002030 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 264198002031 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 264198002032 P-loop, Walker A motif; other site 264198002033 Base recognition motif; other site 264198002034 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 264198002035 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 264198002036 metal binding site 2 [ion binding]; metal-binding site 264198002037 putative DNA binding helix; other site 264198002038 metal binding site 1 [ion binding]; metal-binding site 264198002039 dimer interface [polypeptide binding]; other site 264198002040 structural Zn2+ binding site [ion binding]; other site 264198002041 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 264198002042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198002043 NMT1-like family; Region: NMT1_2; cl15260 264198002044 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 264198002045 active site 264198002046 HslU subunit interaction site [polypeptide binding]; other site 264198002047 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 264198002048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198002049 Walker A motif; other site 264198002050 ATP binding site [chemical binding]; other site 264198002051 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198002052 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 264198002053 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 264198002054 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 264198002055 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 264198002056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198002057 active site 264198002058 phosphorylation site [posttranslational modification] 264198002059 intermolecular recognition site; other site 264198002060 dimerization interface [polypeptide binding]; other site 264198002061 Helix-turn-helix domains; Region: HTH; cl00088 264198002062 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264198002063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198002064 ATP binding site [chemical binding]; other site 264198002065 Mg2+ binding site [ion binding]; other site 264198002066 G-X-G motif; other site 264198002067 Protein of unknown function (DUF461); Region: DUF461; cl01071 264198002068 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 264198002069 Helix-turn-helix domains; Region: HTH; cl00088 264198002070 The C-terminal substrate binding domain of LysR-type transcriptional regulator ToxR regulates the expression of the toxoflavin biosynthesis genes; contains the type 2 periplasmic bindinig fold; Region: PBP2_ToxR; cd08465 264198002071 putative substrate binding pocket [chemical binding]; other site 264198002072 putative dimerization interface [polypeptide binding]; other site 264198002073 Protein of unknown function, DUF606; Region: DUF606; cl01273 264198002074 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 264198002075 Putative zinc-finger; Region: zf-HC2; cl15806 264198002076 RNA polymerase sigma factor; Provisional; Region: PRK12520 264198002077 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264198002078 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264198002079 DNA binding residues [nucleotide binding] 264198002080 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 264198002081 homohexameric interface [polypeptide binding]; other site 264198002082 feedback inhibition sensing region; other site 264198002083 nucleotide binding site [chemical binding]; other site 264198002084 N-acetyl-L-glutamate binding site [chemical binding]; other site 264198002085 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264198002086 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 264198002087 division inhibitor protein; Provisional; Region: slmA; PRK09480 264198002088 Helix-turn-helix domains; Region: HTH; cl00088 264198002089 Inner membrane protein CreD; Region: CreD; cl01844 264198002090 sensory histidine kinase CreC; Provisional; Region: PRK11100 264198002091 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264198002092 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198002093 dimer interface [polypeptide binding]; other site 264198002094 phosphorylation site [posttranslational modification] 264198002095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198002096 ATP binding site [chemical binding]; other site 264198002097 Mg2+ binding site [ion binding]; other site 264198002098 G-X-G motif; other site 264198002099 DNA-binding response regulator CreB; Provisional; Region: PRK11083 264198002100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198002101 active site 264198002102 phosphorylation site [posttranslational modification] 264198002103 intermolecular recognition site; other site 264198002104 dimerization interface [polypeptide binding]; other site 264198002105 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198002106 DNA binding site [nucleotide binding] 264198002107 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 264198002108 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198002109 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198002110 S-adenosylmethionine binding site [chemical binding]; other site 264198002111 LysR family transcriptional regulator; Provisional; Region: PRK14997 264198002112 Helix-turn-helix domains; Region: HTH; cl00088 264198002113 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198002114 putative effector binding pocket; other site 264198002115 dimerization interface [polypeptide binding]; other site 264198002116 EamA-like transporter family; Region: EamA; cl01037 264198002117 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 264198002118 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 264198002119 muropeptide transporter; Validated; Region: ampG; PRK11010 264198002120 muropeptide transporter; Reviewed; Region: ampG; PRK11902 264198002121 Peptidase family M48; Region: Peptidase_M48; cl12018 264198002122 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 264198002123 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198002124 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 264198002125 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 264198002126 putative active site [active] 264198002127 putative catalytic site [active] 264198002128 putative DNA binding site [nucleotide binding]; other site 264198002129 putative phosphate binding site [ion binding]; other site 264198002130 metal binding site A [ion binding]; metal-binding site 264198002131 putative AP binding site [nucleotide binding]; other site 264198002132 putative metal binding site B [ion binding]; other site 264198002133 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264198002134 active site 264198002135 amidophosphoribosyltransferase; Provisional; Region: PRK05793 264198002136 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 264198002137 nucleophile elbow; other site 264198002138 Patatin phospholipase; Region: DUF3734; pfam12536 264198002139 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 264198002140 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 264198002141 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 264198002142 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 264198002143 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 264198002144 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 264198002145 putative acyl-acceptor binding pocket; other site 264198002146 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 264198002147 putative acyl-acceptor binding pocket; other site 264198002148 S-adenosylmethionine synthetase; Validated; Region: PRK05250 264198002149 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 264198002150 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 264198002151 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 264198002152 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 264198002153 choline dehydrogenase; Validated; Region: PRK02106 264198002154 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 264198002155 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 264198002156 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198002157 active site 264198002158 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 264198002159 ThiC-associated domain; Region: ThiC-associated; pfam13667 264198002160 ThiC family; Region: ThiC; cl08031 264198002161 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 264198002162 Ubiquitin-like proteins; Region: UBQ; cl00155 264198002163 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 264198002164 ThiS interaction site; other site 264198002165 putative active site [active] 264198002166 tetramer interface [polypeptide binding]; other site 264198002167 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 264198002168 thiamine phosphate binding site [chemical binding]; other site 264198002169 active site 264198002170 pyrophosphate binding site [ion binding]; other site 264198002171 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 264198002172 CoenzymeA binding site [chemical binding]; other site 264198002173 subunit interaction site [polypeptide binding]; other site 264198002174 PHB binding site; other site 264198002175 PGDYG protein; Region: PGDYG; pfam14083 264198002176 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 264198002177 dimer interface [polypeptide binding]; other site 264198002178 substrate binding site [chemical binding]; other site 264198002179 ATP binding site [chemical binding]; other site 264198002180 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 264198002181 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401 264198002182 oligomerization interface [polypeptide binding]; other site 264198002183 active site 264198002184 NAD+ binding site [chemical binding]; other site 264198002185 Membrane protein of unknown function; Region: DUF360; cl00850 264198002186 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 264198002187 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 264198002188 FAD binding site [chemical binding]; other site 264198002189 TfoX N-terminal domain; Region: TfoX_N; cl01167 264198002190 Ubiquitin-like proteins; Region: UBQ; cl00155 264198002191 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 264198002192 Protein of unknown function DUF82; Region: DUF82; pfam01927 264198002193 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 264198002194 lytic murein transglycosylase; Provisional; Region: PRK11619 264198002195 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 264198002196 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264198002197 catalytic residue [active] 264198002198 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 264198002199 putative NAD(P) binding site [chemical binding]; other site 264198002200 active site 264198002201 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 264198002202 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264198002203 putative C-terminal domain interface [polypeptide binding]; other site 264198002204 putative GSH binding site (G-site) [chemical binding]; other site 264198002205 putative dimer interface [polypeptide binding]; other site 264198002206 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 264198002207 putative N-terminal domain interface [polypeptide binding]; other site 264198002208 putative dimer interface [polypeptide binding]; other site 264198002209 putative substrate binding pocket (H-site) [chemical binding]; other site 264198002210 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 264198002211 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 264198002212 metal binding triad [ion binding]; metal-binding site 264198002213 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 264198002214 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 264198002215 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 264198002216 Uncharacterized conserved protein [Function unknown]; Region: COG1565 264198002217 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 264198002218 pteridine reductase; Provisional; Region: PRK09135 264198002219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198002220 NAD(P) binding site [chemical binding]; other site 264198002221 active site 264198002222 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 264198002223 active site 264198002224 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 264198002225 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 264198002226 Ligand Binding Site [chemical binding]; other site 264198002227 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 264198002228 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 264198002229 Substrate binding site; other site 264198002230 Mg++ binding site; other site 264198002231 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 264198002232 active site 264198002233 substrate binding site [chemical binding]; other site 264198002234 CoA binding site [chemical binding]; other site 264198002235 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 264198002236 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 264198002237 glutaminase active site [active] 264198002238 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 264198002239 dimer interface [polypeptide binding]; other site 264198002240 active site 264198002241 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 264198002242 dimer interface [polypeptide binding]; other site 264198002243 active site 264198002244 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 264198002245 Predicted transporter component [General function prediction only]; Region: COG2391 264198002246 Sulphur transport; Region: Sulf_transp; cl01018 264198002247 Predicted transporter component [General function prediction only]; Region: COG2391 264198002248 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264198002249 dimerization interface [polypeptide binding]; other site 264198002250 putative DNA binding site [nucleotide binding]; other site 264198002251 putative Zn2+ binding site [ion binding]; other site 264198002252 Helix-turn-helix domains; Region: HTH; cl00088 264198002253 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264198002254 Helix-turn-helix domains; Region: HTH; cl00088 264198002255 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 264198002256 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198002257 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198002258 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 264198002259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198002260 putative substrate translocation pore; other site 264198002261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198002262 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 264198002263 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 264198002264 Helix-turn-helix domains; Region: HTH; cl00088 264198002265 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198002266 dimerization interface [polypeptide binding]; other site 264198002267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198002268 NMT1-like family; Region: NMT1_2; cl15260 264198002269 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 264198002270 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 264198002271 heme binding site [chemical binding]; other site 264198002272 ferroxidase pore; other site 264198002273 ferroxidase diiron center [ion binding]; other site 264198002274 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264198002275 Coenzyme A binding pocket [chemical binding]; other site 264198002276 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 264198002277 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 264198002278 NADP binding site [chemical binding]; other site 264198002279 dimer interface [polypeptide binding]; other site 264198002280 Cation efflux family; Region: Cation_efflux; cl00316 264198002281 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 264198002282 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 264198002283 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198002284 DNA-binding site [nucleotide binding]; DNA binding site 264198002285 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198002286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198002287 homodimer interface [polypeptide binding]; other site 264198002288 catalytic residue [active] 264198002289 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 264198002290 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264198002291 inhibitor-cofactor binding pocket; inhibition site 264198002292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198002293 catalytic residue [active] 264198002294 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 264198002295 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198002296 tetrameric interface [polypeptide binding]; other site 264198002297 NAD binding site [chemical binding]; other site 264198002298 catalytic residues [active] 264198002299 amino acid transporter; Region: 2A0306; TIGR00909 264198002300 Spore germination protein; Region: Spore_permease; cl15802 264198002301 Spore germination protein; Region: Spore_permease; cl15802 264198002302 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 264198002303 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198002304 DNA-binding site [nucleotide binding]; DNA binding site 264198002305 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198002306 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198002307 homodimer interface [polypeptide binding]; other site 264198002308 catalytic residue [active] 264198002309 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 264198002310 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 264198002311 B12 binding site [chemical binding]; other site 264198002312 cobalt ligand [ion binding]; other site 264198002313 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 264198002314 Walker A; other site 264198002315 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, unknown subfamily 1; composed of uncharacterized bacterial proteins containing a C-terminal MCM domain. MCM catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA. The...; Region: MM_CoA_mutase_1; cd03678 264198002316 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 264198002317 putative active site [active] 264198002318 putative substrate binding site [chemical binding]; other site 264198002319 putative coenzyme B12 binding site [chemical binding]; other site 264198002320 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 264198002321 HIT family signature motif; other site 264198002322 catalytic residue [active] 264198002323 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 264198002324 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198002325 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 264198002326 Protein of unknown function (DUF2459); Region: DUF2459; cl09819 264198002327 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 264198002328 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198002329 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264198002330 ligand binding site [chemical binding]; other site 264198002331 flexible hinge region; other site 264198002332 Helix-turn-helix domains; Region: HTH; cl00088 264198002333 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 264198002334 AMP-binding enzyme; Region: AMP-binding; cl15778 264198002335 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198002336 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 264198002337 Walker A/P-loop; other site 264198002338 ATP binding site [chemical binding]; other site 264198002339 Q-loop/lid; other site 264198002340 ABC transporter signature motif; other site 264198002341 Walker B; other site 264198002342 D-loop; other site 264198002343 H-loop/switch region; other site 264198002344 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198002345 TM-ABC transporter signature motif; other site 264198002346 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198002347 TM-ABC transporter signature motif; other site 264198002348 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 264198002349 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198002350 putative ligand binding site [chemical binding]; other site 264198002351 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264198002352 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 264198002353 Walker A/P-loop; other site 264198002354 ATP binding site [chemical binding]; other site 264198002355 Q-loop/lid; other site 264198002356 ABC transporter signature motif; other site 264198002357 Walker B; other site 264198002358 D-loop; other site 264198002359 H-loop/switch region; other site 264198002360 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 264198002361 AMP-binding enzyme; Region: AMP-binding; cl15778 264198002362 Protein of unknown function (DUF454); Region: DUF454; cl01063 264198002363 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 264198002364 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 264198002365 FMN binding site [chemical binding]; other site 264198002366 substrate binding site [chemical binding]; other site 264198002367 putative catalytic residue [active] 264198002368 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 264198002369 Helix-turn-helix domains; Region: HTH; cl00088 264198002370 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198002371 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 264198002372 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198002373 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 264198002374 putative active site [active] 264198002375 Fe(II) binding site [ion binding]; other site 264198002376 putative dimer interface [polypeptide binding]; other site 264198002377 putative tetramer interface [polypeptide binding]; other site 264198002378 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 264198002379 benzoate transport; Region: 2A0115; TIGR00895 264198002380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198002381 putative substrate translocation pore; other site 264198002382 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 264198002383 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198002384 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 264198002385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198002386 active site 264198002387 phosphorylation site [posttranslational modification] 264198002388 intermolecular recognition site; other site 264198002389 dimerization interface [polypeptide binding]; other site 264198002390 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198002391 Walker A motif; other site 264198002392 ATP binding site [chemical binding]; other site 264198002393 Walker B motif; other site 264198002394 arginine finger; other site 264198002395 Helix-turn-helix domains; Region: HTH; cl00088 264198002396 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 264198002397 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198002398 dimer interface [polypeptide binding]; other site 264198002399 phosphorylation site [posttranslational modification] 264198002400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198002401 ATP binding site [chemical binding]; other site 264198002402 Mg2+ binding site [ion binding]; other site 264198002403 G-X-G motif; other site 264198002404 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 264198002405 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 264198002406 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 264198002407 dimer interface [polypeptide binding]; other site 264198002408 [2Fe-2S] cluster binding site [ion binding]; other site 264198002409 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 264198002410 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198002411 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 264198002412 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 264198002413 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 264198002414 Protein of unknown function (DUF493); Region: DUF493; cl01102 264198002415 PUA domain; Region: PUA; cl00607 264198002416 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 264198002417 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 264198002418 putative RNA binding site [nucleotide binding]; other site 264198002419 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198002420 S-adenosylmethionine binding site [chemical binding]; other site 264198002421 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 264198002422 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198002423 Family description; Region: UvrD_C_2; cl15862 264198002424 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 264198002425 catalytic residues [active] 264198002426 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 264198002427 LysE type translocator; Region: LysE; cl00565 264198002428 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 264198002429 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 264198002430 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198002431 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 264198002432 Membrane fusogenic activity; Region: BMFP; cl01115 264198002433 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 264198002434 Nitrogen regulatory protein P-II; Region: P-II; cl00412 264198002435 Nitrogen regulatory protein P-II; Region: P-II; smart00938 264198002436 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 264198002437 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 264198002438 Glutamate-cysteine ligase; Region: GshA; pfam08886 264198002439 glutathione synthetase; Provisional; Region: PRK05246 264198002440 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 264198002441 ATP-grasp domain; Region: ATP-grasp_4; cl03087 264198002442 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 264198002443 active pocket/dimerization site; other site 264198002444 active site 264198002445 phosphorylation site [posttranslational modification] 264198002446 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 264198002447 dimerization domain swap beta strand [polypeptide binding]; other site 264198002448 regulatory protein interface [polypeptide binding]; other site 264198002449 active site 264198002450 regulatory phosphorylation site [posttranslational modification]; other site 264198002451 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 264198002452 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 264198002453 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 264198002454 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 264198002455 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 264198002456 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 264198002457 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 264198002458 heme binding site [chemical binding]; other site 264198002459 ferroxidase pore; other site 264198002460 ferroxidase diiron center [ion binding]; other site 264198002461 selenophosphate synthetase; Provisional; Region: PRK00943 264198002462 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 264198002463 dimerization interface [polypeptide binding]; other site 264198002464 putative ATP binding site [chemical binding]; other site 264198002465 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 264198002466 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 264198002467 active site residue [active] 264198002468 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 264198002469 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 264198002470 ATP binding site [chemical binding]; other site 264198002471 substrate interface [chemical binding]; other site 264198002472 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 264198002473 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 264198002474 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 264198002475 protein binding site [polypeptide binding]; other site 264198002476 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 264198002477 Catalytic dyad [active] 264198002478 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264198002479 catalytic core [active] 264198002480 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264198002481 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 264198002482 active site residue [active] 264198002483 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 264198002484 GSH binding site [chemical binding]; other site 264198002485 catalytic residues [active] 264198002486 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 264198002487 SecA binding site; other site 264198002488 Preprotein binding site; other site 264198002489 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 264198002490 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198002491 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 264198002492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198002493 NMT1-like family; Region: NMT1_2; cl15260 264198002494 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 264198002495 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 264198002496 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264198002497 active site 264198002498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198002499 S-adenosylmethionine binding site [chemical binding]; other site 264198002500 Integral membrane protein (DUF2244); Region: DUF2244; cl02302 264198002501 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 264198002502 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 264198002503 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 264198002504 Cytochrome c; Region: Cytochrom_C; cl11414 264198002505 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 264198002506 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 264198002507 Subunit I/III interface [polypeptide binding]; other site 264198002508 D-pathway; other site 264198002509 Subunit I/VIIc interface [polypeptide binding]; other site 264198002510 Subunit I/IV interface [polypeptide binding]; other site 264198002511 Subunit I/II interface [polypeptide binding]; other site 264198002512 Low-spin heme (heme a) binding site [chemical binding]; other site 264198002513 Subunit I/VIIa interface [polypeptide binding]; other site 264198002514 Subunit I/VIa interface [polypeptide binding]; other site 264198002515 Dimer interface; other site 264198002516 Putative water exit pathway; other site 264198002517 Binuclear center (heme a3/CuB) [ion binding]; other site 264198002518 K-pathway; other site 264198002519 Subunit I/Vb interface [polypeptide binding]; other site 264198002520 Putative proton exit pathway; other site 264198002521 Subunit I/VIb interface; other site 264198002522 Subunit I/VIc interface [polypeptide binding]; other site 264198002523 Electron transfer pathway; other site 264198002524 Subunit I/VIIIb interface [polypeptide binding]; other site 264198002525 Subunit I/VIIb interface [polypeptide binding]; other site 264198002526 Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240 264198002527 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 264198002528 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 264198002529 Subunit III/VIIa interface [polypeptide binding]; other site 264198002530 Phospholipid binding site [chemical binding]; other site 264198002531 Subunit I/III interface [polypeptide binding]; other site 264198002532 Subunit III/VIb interface [polypeptide binding]; other site 264198002533 Subunit III/VIa interface; other site 264198002534 Subunit III/Vb interface [polypeptide binding]; other site 264198002535 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 264198002536 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 264198002537 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 264198002538 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 264198002539 UbiA prenyltransferase family; Region: UbiA; cl00337 264198002540 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 264198002541 Cu(I) binding site [ion binding]; other site 264198002542 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 264198002543 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264198002544 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264198002545 DNA binding residues [nucleotide binding] 264198002546 Pirin-related protein [General function prediction only]; Region: COG1741 264198002547 Cupin domain; Region: Cupin_2; cl09118 264198002548 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 264198002549 glycosyl transferase family protein; Provisional; Region: PRK08136 264198002550 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 264198002551 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 264198002552 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 264198002553 Walker A/P-loop; other site 264198002554 ATP binding site [chemical binding]; other site 264198002555 Q-loop/lid; other site 264198002556 ABC transporter signature motif; other site 264198002557 Walker B; other site 264198002558 D-loop; other site 264198002559 H-loop/switch region; other site 264198002560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198002561 dimer interface [polypeptide binding]; other site 264198002562 conserved gate region; other site 264198002563 putative PBP binding loops; other site 264198002564 ABC-ATPase subunit interface; other site 264198002565 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 264198002566 NMT1-like family; Region: NMT1_2; cl15260 264198002567 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 264198002568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 264198002569 active site 264198002570 phosphorylation site [posttranslational modification] 264198002571 intermolecular recognition site; other site 264198002572 dimerization interface [polypeptide binding]; other site 264198002573 ANTAR domain; Region: ANTAR; cl04297 264198002574 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 264198002575 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 264198002576 maleylacetoacetate isomerase; Region: maiA; TIGR01262 264198002577 C-terminal domain interface [polypeptide binding]; other site 264198002578 GSH binding site (G-site) [chemical binding]; other site 264198002579 putative dimer interface [polypeptide binding]; other site 264198002580 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 264198002581 dimer interface [polypeptide binding]; other site 264198002582 N-terminal domain interface [polypeptide binding]; other site 264198002583 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 264198002584 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 264198002585 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 264198002586 P loop; other site 264198002587 GTP binding site [chemical binding]; other site 264198002588 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 264198002589 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 264198002590 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 264198002591 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 264198002592 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 264198002593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198002594 S-adenosylmethionine binding site [chemical binding]; other site 264198002595 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 264198002596 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 264198002597 active site 264198002598 (T/H)XGH motif; other site 264198002599 ferredoxin; Validated; Region: PRK07118 264198002600 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 264198002601 putative active site [active] 264198002602 catalytic residue [active] 264198002603 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 264198002604 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 264198002605 5S rRNA interface [nucleotide binding]; other site 264198002606 CTC domain interface [polypeptide binding]; other site 264198002607 L16 interface [polypeptide binding]; other site 264198002608 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 264198002609 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 264198002610 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264198002611 active site 264198002612 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 264198002613 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 264198002614 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 264198002615 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 264198002616 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700 264198002617 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264198002618 binding surface 264198002619 TPR motif; other site 264198002620 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 264198002621 TPR motif; other site 264198002622 binding surface 264198002623 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264198002624 binding surface 264198002625 TPR motif; other site 264198002626 TPR repeat; Region: TPR_11; pfam13414 264198002627 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264198002628 binding surface 264198002629 TPR motif; other site 264198002630 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 264198002631 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 264198002632 DNA binding site [nucleotide binding] 264198002633 catalytic residue [active] 264198002634 H2TH interface [polypeptide binding]; other site 264198002635 putative catalytic residues [active] 264198002636 turnover-facilitating residue; other site 264198002637 intercalation triad [nucleotide binding]; other site 264198002638 8OG recognition residue [nucleotide binding]; other site 264198002639 putative reading head residues; other site 264198002640 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 264198002641 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 264198002642 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198002643 Dynamin family; Region: Dynamin_N; pfam00350 264198002644 G1 box; other site 264198002645 GTP/Mg2+ binding site [chemical binding]; other site 264198002646 G2 box; other site 264198002647 Switch I region; other site 264198002648 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 264198002649 G3 box; other site 264198002650 Switch II region; other site 264198002651 GTP/Mg2+ binding site [chemical binding]; other site 264198002652 G4 box; other site 264198002653 G5 box; other site 264198002654 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 264198002655 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 264198002656 minor groove reading motif; other site 264198002657 helix-hairpin-helix signature motif; other site 264198002658 substrate binding pocket [chemical binding]; other site 264198002659 active site 264198002660 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 264198002661 DNA binding and oxoG recognition site [nucleotide binding] 264198002662 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 264198002663 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 264198002664 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 264198002665 hypothetical protein; Provisional; Region: PRK11505 264198002666 psiF repeat; Region: PsiF_repeat; pfam07769 264198002667 HPr kinase/phosphorylase; Provisional; Region: PRK05428 264198002668 DRTGG domain; Region: DRTGG; cl12147 264198002669 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 264198002670 Hpr binding site; other site 264198002671 active site 264198002672 homohexamer subunit interaction site [polypeptide binding]; other site 264198002673 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 264198002674 active site 264198002675 phosphorylation site [posttranslational modification] 264198002676 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 264198002677 30S subunit binding site; other site 264198002678 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 264198002679 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 264198002680 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 264198002681 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 264198002682 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 264198002683 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 264198002684 Walker A/P-loop; other site 264198002685 ATP binding site [chemical binding]; other site 264198002686 Q-loop/lid; other site 264198002687 ABC transporter signature motif; other site 264198002688 Walker B; other site 264198002689 D-loop; other site 264198002690 H-loop/switch region; other site 264198002691 OstA-like protein; Region: OstA; cl00844 264198002692 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 264198002693 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 264198002694 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 264198002695 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 264198002696 putative active site [active] 264198002697 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 264198002698 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 264198002699 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 264198002700 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198002701 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 264198002702 Ribbon-helix-helix domain; Region: RHH_4; cl01775 264198002703 intracellular protease, PfpI family; Region: PfpI; TIGR01382 264198002704 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 264198002705 conserved cys residue [active] 264198002706 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264198002707 active site 264198002708 LysE type translocator; Region: LysE; cl00565 264198002709 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 264198002710 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 264198002711 PhoU domain; Region: PhoU; pfam01895 264198002712 PhoU domain; Region: PhoU; pfam01895 264198002713 Adenosine specific kinase; Region: Adenosine_kin; cl00796 264198002714 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 264198002715 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 264198002716 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 264198002717 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 264198002718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198002719 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198002720 putative substrate translocation pore; other site 264198002721 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 264198002722 dimer interface [polypeptide binding]; other site 264198002723 ssDNA binding site [nucleotide binding]; other site 264198002724 tetramer (dimer of dimers) interface [polypeptide binding]; other site 264198002725 NMT1-like family; Region: NMT1_2; cl15260 264198002726 autotransport protein MisL; Provisional; Region: PRK15313 264198002727 Protein of unknown function (DUF342); Region: DUF342; pfam03961 264198002728 autotransport protein MisL; Provisional; Region: PRK15313 264198002729 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 264198002730 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 264198002731 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 264198002732 Protein of unknown function, DUF485; Region: DUF485; cl01231 264198002733 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 264198002734 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 264198002735 Na binding site [ion binding]; other site 264198002736 delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945 264198002737 Haemagglutinin; Region: HIM; pfam05662 264198002738 YadA-like C-terminal region; Region: YadA; pfam03895 264198002739 Cupin domain; Region: Cupin_2; cl09118 264198002740 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 264198002741 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198002742 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198002743 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198002744 Cupin domain; Region: Cupin_2; cl09118 264198002745 Uncharacterized conserved protein [Function unknown]; Region: COG5361 264198002746 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 264198002747 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 264198002748 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 264198002749 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 264198002750 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 264198002751 tetramer interface [polypeptide binding]; other site 264198002752 active site 264198002753 Mg2+/Mn2+ binding site [ion binding]; other site 264198002754 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 264198002755 mercuric reductase; Validated; Region: PRK06370 264198002756 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198002757 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198002758 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 264198002759 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 264198002760 nucleophile elbow; other site 264198002761 Patatin phospholipase; Region: DUF3734; pfam12536 264198002762 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 264198002763 osmolarity response regulator; Provisional; Region: ompR; PRK09468 264198002764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198002765 active site 264198002766 phosphorylation site [posttranslational modification] 264198002767 intermolecular recognition site; other site 264198002768 dimerization interface [polypeptide binding]; other site 264198002769 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198002770 DNA binding site [nucleotide binding] 264198002771 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 264198002772 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264198002773 dimerization interface [polypeptide binding]; other site 264198002774 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198002775 dimer interface [polypeptide binding]; other site 264198002776 phosphorylation site [posttranslational modification] 264198002777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198002778 ATP binding site [chemical binding]; other site 264198002779 Mg2+ binding site [ion binding]; other site 264198002780 G-X-G motif; other site 264198002781 Domain of unknown function (DUF4410); Region: DUF4410; pfam14366 264198002782 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 264198002783 Ion channel; Region: Ion_trans_2; cl11596 264198002784 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 264198002785 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198002786 substrate binding pocket [chemical binding]; other site 264198002787 membrane-bound complex binding site; other site 264198002788 hinge residues; other site 264198002789 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 264198002790 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 264198002791 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 264198002792 putative active site [active] 264198002793 hypothetical protein; Provisional; Region: PRK07483 264198002794 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264198002795 inhibitor-cofactor binding pocket; inhibition site 264198002796 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198002797 catalytic residue [active] 264198002798 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 264198002799 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 264198002800 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 264198002801 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 264198002802 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 264198002803 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 264198002804 aspartate aminotransferase; Provisional; Region: PRK06108 264198002805 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198002806 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198002807 homodimer interface [polypeptide binding]; other site 264198002808 catalytic residue [active] 264198002809 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264198002810 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 264198002811 ABC-2 type transporter; Region: ABC2_membrane; cl11417 264198002812 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 264198002813 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 264198002814 Walker A/P-loop; other site 264198002815 ATP binding site [chemical binding]; other site 264198002816 Q-loop/lid; other site 264198002817 ABC transporter signature motif; other site 264198002818 Walker B; other site 264198002819 D-loop; other site 264198002820 H-loop/switch region; other site 264198002821 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264198002822 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198002823 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198002824 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198002825 Helix-turn-helix domains; Region: HTH; cl00088 264198002826 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 264198002827 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 264198002828 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 264198002829 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 264198002830 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 264198002831 threonine dehydratase; Reviewed; Region: PRK09224 264198002832 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 264198002833 tetramer interface [polypeptide binding]; other site 264198002834 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198002835 catalytic residue [active] 264198002836 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 264198002837 putative Ile/Val binding site [chemical binding]; other site 264198002838 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 264198002839 putative Ile/Val binding site [chemical binding]; other site 264198002840 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264198002841 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 264198002842 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 264198002843 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 264198002844 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 264198002845 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 264198002846 active site 264198002847 homotetramer interface [polypeptide binding]; other site 264198002848 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 264198002849 aromatic arch; other site 264198002850 DCoH dimer interaction site [polypeptide binding]; other site 264198002851 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 264198002852 DCoH tetramer interaction site [polypeptide binding]; other site 264198002853 substrate binding site [chemical binding]; other site 264198002854 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 264198002855 Ligand binding site; other site 264198002856 metal-binding site 264198002857 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 264198002858 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 264198002859 XdhC Rossmann domain; Region: XdhC_C; pfam13478 264198002860 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 264198002861 putative hydrophobic ligand binding site [chemical binding]; other site 264198002862 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 264198002863 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 264198002864 metal ion-dependent adhesion site (MIDAS); other site 264198002865 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198002866 Walker A motif; other site 264198002867 ATP binding site [chemical binding]; other site 264198002868 Walker B motif; other site 264198002869 arginine finger; other site 264198002870 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 264198002871 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 264198002872 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 264198002873 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 264198002874 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264198002875 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 264198002876 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 264198002877 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 264198002878 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 264198002879 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 264198002880 FAD binding domain; Region: FAD_binding_4; pfam01565 264198002881 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 264198002882 Heterodisulfide reductase, subunit C [Energy production and conversion]; Region: HdrC; COG1150 264198002883 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 264198002884 Cysteine-rich domain; Region: CCG; pfam02754 264198002885 Cysteine-rich domain; Region: CCG; pfam02754 264198002886 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 264198002887 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 264198002888 nucleotide binding site/active site [active] 264198002889 HIT family signature motif; other site 264198002890 catalytic residue [active] 264198002891 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 264198002892 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 264198002893 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 264198002894 Protein of unknown function (DUF971); Region: DUF971; cl01414 264198002895 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 264198002896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198002897 S-adenosylmethionine binding site [chemical binding]; other site 264198002898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 264198002899 Tim44-like domain; Region: Tim44; cl09208 264198002900 SCP-2 sterol transfer family; Region: SCP2; cl01225 264198002901 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198002902 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 264198002903 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198002904 S-adenosylmethionine binding site [chemical binding]; other site 264198002905 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 264198002906 Na binding site [ion binding]; other site 264198002907 putative glycosylation site [posttranslational modification]; other site 264198002908 putative glycosylation site [posttranslational modification]; other site 264198002909 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 264198002910 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 264198002911 Protein of unknown function (DUF502); Region: DUF502; cl01107 264198002912 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 264198002913 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 264198002914 dimer interface [polypeptide binding]; other site 264198002915 anticodon binding site; other site 264198002916 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 264198002917 homodimer interface [polypeptide binding]; other site 264198002918 motif 1; other site 264198002919 active site 264198002920 motif 2; other site 264198002921 GAD domain; Region: GAD; pfam02938 264198002922 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 264198002923 motif 3; other site 264198002924 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 264198002925 nudix motif; other site 264198002926 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 264198002927 putative catalytic site [active] 264198002928 putative metal binding site [ion binding]; other site 264198002929 putative phosphate binding site [ion binding]; other site 264198002930 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 264198002931 Walker A motif; other site 264198002932 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 264198002933 PLD-like domain; Region: PLDc_2; pfam13091 264198002934 putative active site [active] 264198002935 catalytic site [active] 264198002936 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 264198002937 PLD-like domain; Region: PLDc_2; pfam13091 264198002938 putative active site [active] 264198002939 catalytic site [active] 264198002940 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198002941 Helix-turn-helix domains; Region: HTH; cl00088 264198002942 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 264198002943 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 264198002944 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198002945 active site 264198002946 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 264198002947 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 264198002948 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198002949 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 264198002950 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198002951 substrate binding site [chemical binding]; other site 264198002952 oxyanion hole (OAH) forming residues; other site 264198002953 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 264198002954 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264198002955 dimer interface [polypeptide binding]; other site 264198002956 active site 264198002957 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 264198002958 enoyl-CoA hydratase; Provisional; Region: PRK06688 264198002959 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198002960 substrate binding site [chemical binding]; other site 264198002961 oxyanion hole (OAH) forming residues; other site 264198002962 trimer interface [polypeptide binding]; other site 264198002963 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 264198002964 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 264198002965 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 264198002966 ATM1 is an ABC transporter that is expressed in the mitochondria. Although the specific function of ATM1 is unknown, its disruption results in the accumulation of excess mitochondrial iron, loss of mitochondrial cytochromes, oxidative damage to...; Region: ABCC_ATM1_transporter; cd03253 264198002967 Walker A/P-loop; other site 264198002968 ATP binding site [chemical binding]; other site 264198002969 Q-loop/lid; other site 264198002970 ABC transporter signature motif; other site 264198002971 Walker B; other site 264198002972 D-loop; other site 264198002973 H-loop/switch region; other site 264198002974 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264198002975 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264198002976 putative DNA binding site [nucleotide binding]; other site 264198002977 putative Zn2+ binding site [ion binding]; other site 264198002978 AsnC family; Region: AsnC_trans_reg; pfam01037 264198002979 Cysteine dioxygenase type I; Region: CDO_I; cl15835 264198002980 Helix-turn-helix domains; Region: HTH; cl00088 264198002981 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264198002982 dimerization interface [polypeptide binding]; other site 264198002983 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 264198002984 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 264198002985 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 264198002986 NAD(P) binding site [chemical binding]; other site 264198002987 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 264198002988 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198002989 substrate binding pocket [chemical binding]; other site 264198002990 membrane-bound complex binding site; other site 264198002991 hinge residues; other site 264198002992 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 264198002993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198002994 dimer interface [polypeptide binding]; other site 264198002995 conserved gate region; other site 264198002996 putative PBP binding loops; other site 264198002997 ABC-ATPase subunit interface; other site 264198002998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198002999 dimer interface [polypeptide binding]; other site 264198003000 conserved gate region; other site 264198003001 putative PBP binding loops; other site 264198003002 ABC-ATPase subunit interface; other site 264198003003 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 264198003004 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 264198003005 Walker A/P-loop; other site 264198003006 ATP binding site [chemical binding]; other site 264198003007 Q-loop/lid; other site 264198003008 ABC transporter signature motif; other site 264198003009 Walker B; other site 264198003010 D-loop; other site 264198003011 H-loop/switch region; other site 264198003012 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 264198003013 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 264198003014 putative active site [active] 264198003015 putative dimer interface [polypeptide binding]; other site 264198003016 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 264198003017 tartrate dehydrogenase; Provisional; Region: PRK08194 264198003018 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 264198003019 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 264198003020 MOFRL family; Region: MOFRL; pfam05161 264198003021 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 264198003022 active site 264198003023 substrate binding pocket [chemical binding]; other site 264198003024 dimer interface [polypeptide binding]; other site 264198003025 Protein of unknown function (DUF3025); Region: DUF3025; pfam11227 264198003026 OsmC-like protein; Region: OsmC; cl00767 264198003027 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 264198003028 23S rRNA interface [nucleotide binding]; other site 264198003029 L3 interface [polypeptide binding]; other site 264198003030 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 264198003031 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 264198003032 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 264198003033 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 264198003034 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198003035 Helix-turn-helix domains; Region: HTH; cl00088 264198003036 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198003037 dimerization interface [polypeptide binding]; other site 264198003038 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 264198003039 Peptidase family M23; Region: Peptidase_M23; pfam01551 264198003040 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 264198003041 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 264198003042 active site 264198003043 HIGH motif; other site 264198003044 dimer interface [polypeptide binding]; other site 264198003045 KMSKS motif; other site 264198003046 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 264198003047 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 264198003048 putative active site [active] 264198003049 dimerization interface [polypeptide binding]; other site 264198003050 putative tRNAtyr binding site [nucleotide binding]; other site 264198003051 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 264198003052 substrate binding site [chemical binding]; other site 264198003053 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264198003054 catalytic core [active] 264198003055 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 264198003056 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 264198003057 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 264198003058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198003059 Walker A motif; other site 264198003060 ATP binding site [chemical binding]; other site 264198003061 Walker B motif; other site 264198003062 arginine finger; other site 264198003063 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 264198003064 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 264198003065 RuvA N terminal domain; Region: RuvA_N; pfam01330 264198003066 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 264198003067 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 264198003068 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 264198003069 putative active site [active] 264198003070 catalytic site [active] 264198003071 putative metal binding site [ion binding]; other site 264198003072 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 264198003073 active site 264198003074 putative DNA-binding cleft [nucleotide binding]; other site 264198003075 dimer interface [polypeptide binding]; other site 264198003076 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 264198003077 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 264198003078 purine monophosphate binding site [chemical binding]; other site 264198003079 dimer interface [polypeptide binding]; other site 264198003080 putative catalytic residues [active] 264198003081 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 264198003082 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 264198003083 Helix-turn-helix domains; Region: HTH; cl00088 264198003084 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 264198003085 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 264198003086 FMN binding site [chemical binding]; other site 264198003087 active site 264198003088 catalytic residues [active] 264198003089 substrate binding site [chemical binding]; other site 264198003090 hypothetical protein; Provisional; Region: PRK06996 264198003091 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198003092 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 264198003093 proline aminopeptidase P II; Provisional; Region: PRK10879 264198003094 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 264198003095 active site 264198003096 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 264198003097 Substrate binding site; other site 264198003098 metal-binding site 264198003099 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 264198003100 AzlC protein; Region: AzlC; cl00570 264198003101 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198003102 Phosphotransferase enzyme family; Region: APH; pfam01636 264198003103 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 264198003104 OstA-like protein; Region: OstA; cl00844 264198003105 Organic solvent tolerance protein; Region: OstA_C; pfam04453 264198003106 SurA N-terminal domain; Region: SurA_N_3; cl07813 264198003107 PPIC-type PPIASE domain; Region: Rotamase; cl08278 264198003108 PPIC-type PPIASE domain; Region: Rotamase; cl08278 264198003109 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 264198003110 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 264198003111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 264198003112 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 264198003113 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 264198003114 active site 264198003115 HIGH motif; other site 264198003116 dimer interface [polypeptide binding]; other site 264198003117 KMSKS motif; other site 264198003118 EamA-like transporter family; Region: EamA; cl01037 264198003119 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198003120 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 264198003121 dimer interface [polypeptide binding]; other site 264198003122 active site 264198003123 metal binding site [ion binding]; metal-binding site 264198003124 glutathione binding site [chemical binding]; other site 264198003125 Protein of unknown function DUF45; Region: DUF45; cl00636 264198003126 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 264198003127 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 264198003128 putative acyl-acceptor binding pocket; other site 264198003129 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 264198003130 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264198003131 active site 264198003132 motif I; other site 264198003133 motif II; other site 264198003134 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 264198003135 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 264198003136 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 264198003137 dimer interface [polypeptide binding]; other site 264198003138 motif 1; other site 264198003139 active site 264198003140 motif 2; other site 264198003141 motif 3; other site 264198003142 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 264198003143 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 264198003144 putative active site [active] 264198003145 catalytic triad [active] 264198003146 putative dimer interface [polypeptide binding]; other site 264198003147 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 264198003148 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 264198003149 Transporter associated domain; Region: CorC_HlyC; cl08393 264198003150 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 264198003151 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 264198003152 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198003153 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 264198003154 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 264198003155 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264198003156 FeS/SAM binding site; other site 264198003157 TRAM domain; Region: TRAM; cl01282 264198003158 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 264198003159 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 264198003160 Cl- selectivity filter; other site 264198003161 Cl- binding residues [ion binding]; other site 264198003162 pore gating glutamate residue; other site 264198003163 dimer interface [polypeptide binding]; other site 264198003164 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 264198003165 helicase 45; Provisional; Region: PTZ00424 264198003166 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 264198003167 ATP binding site [chemical binding]; other site 264198003168 Mg++ binding site [ion binding]; other site 264198003169 motif III; other site 264198003170 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264198003171 nucleotide binding region [chemical binding]; other site 264198003172 ATP-binding site [chemical binding]; other site 264198003173 Phosphotransferase enzyme family; Region: APH; pfam01636 264198003174 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198003175 active site 264198003176 ATP binding site [chemical binding]; other site 264198003177 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198003178 Ligand Binding Site [chemical binding]; other site 264198003179 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198003180 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 264198003181 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198003182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198003183 active site 264198003184 phosphorylation site [posttranslational modification] 264198003185 intermolecular recognition site; other site 264198003186 dimerization interface [polypeptide binding]; other site 264198003187 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198003188 DNA binding residues [nucleotide binding] 264198003189 dimerization interface [polypeptide binding]; other site 264198003190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198003191 putative substrate translocation pore; other site 264198003192 metabolite-proton symporter; Region: 2A0106; TIGR00883 264198003193 Domain of unknown function (DUF4212); Region: DUF4212; cl01781 264198003194 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 264198003195 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264198003196 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264198003197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198003198 dimer interface [polypeptide binding]; other site 264198003199 phosphorylation site [posttranslational modification] 264198003200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198003201 ATP binding site [chemical binding]; other site 264198003202 Mg2+ binding site [ion binding]; other site 264198003203 G-X-G motif; other site 264198003204 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 264198003205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198003206 active site 264198003207 phosphorylation site [posttranslational modification] 264198003208 intermolecular recognition site; other site 264198003209 dimerization interface [polypeptide binding]; other site 264198003210 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198003211 DNA binding site [nucleotide binding] 264198003212 recombinase A; Provisional; Region: recA; PRK09354 264198003213 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 264198003214 hexamer interface [polypeptide binding]; other site 264198003215 Walker A motif; other site 264198003216 ATP binding site [chemical binding]; other site 264198003217 Walker B motif; other site 264198003218 RecX family; Region: RecX; cl00936 264198003219 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 264198003220 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 264198003221 ATP-grasp domain; Region: ATP-grasp_4; cl03087 264198003222 CoA-ligase; Region: Ligase_CoA; cl02894 264198003223 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 264198003224 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198003225 CoA-ligase; Region: Ligase_CoA; cl02894 264198003226 Integral membrane protein TerC family; Region: TerC; cl10468 264198003227 putative major pilin subunit; Provisional; Region: PRK10574 264198003228 O-Antigen ligase; Region: Wzy_C; cl04850 264198003229 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 264198003230 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 264198003231 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 264198003232 DNA-binding site [nucleotide binding]; DNA binding site 264198003233 RNA-binding motif; other site 264198003234 Excalibur calcium-binding domain; Region: Excalibur; cl05460 264198003235 Restriction endonuclease; Region: Mrr_cat; cl00516 264198003236 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 264198003237 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198003238 metal binding site [ion binding]; metal-binding site 264198003239 active site 264198003240 I-site; other site 264198003241 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 264198003242 trimer interface [polypeptide binding]; other site 264198003243 dimer interface [polypeptide binding]; other site 264198003244 putative active site [active] 264198003245 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 264198003246 Peptidase family M48; Region: Peptidase_M48; cl12018 264198003247 Protein of unknown function (DUF2946); Region: DUF2944; pfam11161 264198003248 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 264198003249 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 264198003250 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 264198003251 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 264198003252 putative active site [active] 264198003253 Zinc-finger domain; Region: zf-CHCC; cl01821 264198003254 DEAD-like helicases superfamily; Region: DEXDc; smart00487 264198003255 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264198003256 ATP binding site [chemical binding]; other site 264198003257 putative Mg++ binding site [ion binding]; other site 264198003258 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264198003259 nucleotide binding region [chemical binding]; other site 264198003260 ATP-binding site [chemical binding]; other site 264198003261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198003262 NMT1-like family; Region: NMT1_2; cl15260 264198003263 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 264198003264 PAAR motif; Region: PAAR_motif; cl15808 264198003265 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 264198003266 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 264198003267 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 264198003268 ATP-grasp domain; Region: ATP-grasp_4; cl03087 264198003269 AIR carboxylase; Region: AIRC; cl00310 264198003270 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 264198003271 ATP binding site [chemical binding]; other site 264198003272 active site 264198003273 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 264198003274 substrate binding site [chemical binding]; other site 264198003275 hypothetical protein; Provisional; Region: PRK08185 264198003276 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 264198003277 intersubunit interface [polypeptide binding]; other site 264198003278 active site 264198003279 zinc binding site [ion binding]; other site 264198003280 Na+ binding site [ion binding]; other site 264198003281 pyruvate kinase; Provisional; Region: PRK05826 264198003282 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 264198003283 domain interfaces; other site 264198003284 active site 264198003285 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 264198003286 Phosphoglycerate kinase; Region: PGK; pfam00162 264198003287 substrate binding site [chemical binding]; other site 264198003288 hinge regions; other site 264198003289 ADP binding site [chemical binding]; other site 264198003290 catalytic site [active] 264198003291 Helix-turn-helix domains; Region: HTH; cl00088 264198003292 Helix-turn-helix domains; Region: HTH; cl00088 264198003293 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 264198003294 AzlC protein; Region: AzlC; cl00570 264198003295 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 264198003296 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 264198003297 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264198003298 Helix-turn-helix domains; Region: HTH; cl00088 264198003299 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 264198003300 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 264198003301 Helix-turn-helix domains; Region: HTH; cl00088 264198003302 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198003303 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264198003304 dimerization interface [polypeptide binding]; other site 264198003305 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264198003306 MULE transposase domain; Region: MULE; pfam10551 264198003307 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264198003308 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 264198003309 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 264198003310 Protein export membrane protein; Region: SecD_SecF; cl14618 264198003311 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 264198003312 Protein export membrane protein; Region: SecD_SecF; cl14618 264198003313 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 264198003314 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198003315 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264198003316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198003317 active site 264198003318 phosphorylation site [posttranslational modification] 264198003319 intermolecular recognition site; other site 264198003320 dimerization interface [polypeptide binding]; other site 264198003321 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198003322 DNA binding site [nucleotide binding] 264198003323 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 264198003324 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264198003325 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198003326 dimer interface [polypeptide binding]; other site 264198003327 phosphorylation site [posttranslational modification] 264198003328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198003329 ATP binding site [chemical binding]; other site 264198003330 Mg2+ binding site [ion binding]; other site 264198003331 G-X-G motif; other site 264198003332 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 264198003333 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 264198003334 putative deacylase active site [active] 264198003335 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 264198003336 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 264198003337 active site 264198003338 Int/Topo IB signature motif; other site 264198003339 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 264198003340 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 264198003341 DNA binding site [nucleotide binding] 264198003342 active site 264198003343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198003344 NMT1-like family; Region: NMT1_2; cl15260 264198003345 Membrane transport protein; Region: Mem_trans; cl09117 264198003346 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 264198003347 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 264198003348 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 264198003349 AMIN domain; Region: AMIN; pfam11741 264198003350 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 264198003351 active site 264198003352 metal binding site [ion binding]; metal-binding site 264198003353 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 264198003354 Membrane transport protein; Region: Mem_trans; cl09117 264198003355 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 264198003356 Helix-turn-helix domains; Region: HTH; cl00088 264198003357 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 264198003358 putative dimerization interface [polypeptide binding]; other site 264198003359 Methyltransferase domain; Region: Methyltransf_31; pfam13847 264198003360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198003361 S-adenosylmethionine binding site [chemical binding]; other site 264198003362 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 264198003363 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 264198003364 NAD binding site [chemical binding]; other site 264198003365 homodimer interface [polypeptide binding]; other site 264198003366 homotetramer interface [polypeptide binding]; other site 264198003367 active site 264198003368 adenylate kinase; Reviewed; Region: adk; PRK00279 264198003369 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 264198003370 AMP-binding site [chemical binding]; other site 264198003371 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 264198003372 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 264198003373 Ligand binding site; other site 264198003374 oligomer interface; other site 264198003375 Trm112p-like protein; Region: Trm112p; cl01066 264198003376 tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906 264198003377 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 264198003378 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 264198003379 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 264198003380 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 264198003381 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 264198003382 generic binding surface II; other site 264198003383 generic binding surface I; other site 264198003384 superoxide dismutase; Provisional; Region: PRK10543 264198003385 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 264198003386 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 264198003387 Domain of unknown function (DUF305); Region: DUF305; cl15795 264198003388 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 264198003389 Protein of unknown function DUF72; Region: DUF72; cl00777 264198003390 CheB methylesterase; Region: CheB_methylest; pfam01339 264198003391 Competence-damaged protein; Region: CinA; cl00666 264198003392 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 264198003393 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 264198003394 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; cl01353 264198003395 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 264198003396 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 264198003397 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 264198003398 Ferredoxin [Energy production and conversion]; Region: COG1146 264198003399 4Fe-4S binding domain; Region: Fer4; cl02805 264198003400 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 264198003401 Helix-turn-helix domains; Region: HTH; cl00088 264198003402 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198003403 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 264198003404 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 264198003405 putative dimer interface [polypeptide binding]; other site 264198003406 [2Fe-2S] cluster binding site [ion binding]; other site 264198003407 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 264198003408 putative dimer interface [polypeptide binding]; other site 264198003409 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 264198003410 SLBB domain; Region: SLBB; pfam10531 264198003411 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 264198003412 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 264198003413 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198003414 catalytic loop [active] 264198003415 iron binding site [ion binding]; other site 264198003416 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 264198003417 4Fe-4S binding domain; Region: Fer4; cl02805 264198003418 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 264198003419 [4Fe-4S] binding site [ion binding]; other site 264198003420 molybdopterin cofactor binding site; other site 264198003421 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 264198003422 molybdopterin cofactor binding site; other site 264198003423 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 264198003424 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 264198003425 Transglycosylase; Region: Transgly; cl07896 264198003426 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cl02586 264198003427 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 264198003428 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 264198003429 acetate kinase; Region: ackA; TIGR00016 264198003430 Acetokinase family; Region: Acetate_kinase; cl01029 264198003431 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 264198003432 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 264198003433 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 264198003434 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 264198003435 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 264198003436 NAD binding site [chemical binding]; other site 264198003437 homotetramer interface [polypeptide binding]; other site 264198003438 homodimer interface [polypeptide binding]; other site 264198003439 substrate binding site [chemical binding]; other site 264198003440 active site 264198003441 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cl02586 264198003442 Helix-turn-helix domains; Region: HTH; cl00088 264198003443 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 264198003444 TOBE domain; Region: TOBE_2; cl01440 264198003445 TOBE domain; Region: TOBE_2; cl01440 264198003446 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 264198003447 putative active site [active] 264198003448 putative metal binding residues [ion binding]; other site 264198003449 signature motif; other site 264198003450 putative triphosphate binding site [ion binding]; other site 264198003451 dimer interface [polypeptide binding]; other site 264198003452 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198003453 Walker A/P-loop; other site 264198003454 ATP binding site [chemical binding]; other site 264198003455 ABC transporter; Region: ABC_tran; pfam00005 264198003456 Q-loop/lid; other site 264198003457 ABC transporter signature motif; other site 264198003458 Walker B; other site 264198003459 D-loop; other site 264198003460 H-loop/switch region; other site 264198003461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198003462 putative PBP binding loops; other site 264198003463 dimer interface [polypeptide binding]; other site 264198003464 ABC-ATPase subunit interface; other site 264198003465 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 264198003466 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198003467 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 264198003468 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198003469 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl16918 264198003470 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264198003471 MULE transposase domain; Region: MULE; pfam10551 264198003472 Dehydratase family; Region: ILVD_EDD; cl00340 264198003473 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 264198003474 Helix-turn-helix domains; Region: HTH; cl00088 264198003475 The C-terminal substrate binding domain of LysR-type transcriptional regulator, IlvR, involved in the biosynthesis of isoleucine, leucine and valine; contains type 2 periplasmic binding fold; Region: PBP2_IlvR; cd08453 264198003476 putative dimerization interface [polypeptide binding]; other site 264198003477 putative substrate binding pocket [chemical binding]; other site 264198003478 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 264198003479 Peptidase family M48; Region: Peptidase_M48; cl12018 264198003480 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 264198003481 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264198003482 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198003483 DNA-binding site [nucleotide binding]; DNA binding site 264198003484 FCD domain; Region: FCD; cl11656 264198003485 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 264198003486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198003487 NMT1-like family; Region: NMT1_2; cl15260 264198003488 enoyl-CoA hydratase; Provisional; Region: PRK06127 264198003489 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198003490 substrate binding site [chemical binding]; other site 264198003491 oxyanion hole (OAH) forming residues; other site 264198003492 trimer interface [polypeptide binding]; other site 264198003493 malonyl-CoA synthase; Validated; Region: PRK07514 264198003494 AMP-binding enzyme; Region: AMP-binding; cl15778 264198003495 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198003496 Protein of unknown function (DUF541); Region: SIMPL; cl01077 264198003497 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 264198003498 EVE domain; Region: EVE; cl00728 264198003499 Cell division protein ZapA; Region: ZapA; cl01146 264198003500 Autophagy protein Apg6; Region: APG6; pfam04111 264198003501 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 264198003502 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264198003503 N-terminal plug; other site 264198003504 ligand-binding site [chemical binding]; other site 264198003505 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 264198003506 ABC-ATPase subunit interface; other site 264198003507 dimer interface [polypeptide binding]; other site 264198003508 putative PBP binding regions; other site 264198003509 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 264198003510 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 264198003511 Walker A/P-loop; other site 264198003512 ATP binding site [chemical binding]; other site 264198003513 Q-loop/lid; other site 264198003514 ABC transporter signature motif; other site 264198003515 Walker B; other site 264198003516 D-loop; other site 264198003517 H-loop/switch region; other site 264198003518 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 264198003519 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198003520 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 264198003521 homodimer interface [polypeptide binding]; other site 264198003522 Walker A motif; other site 264198003523 ATP binding site [chemical binding]; other site 264198003524 hydroxycobalamin binding site [chemical binding]; other site 264198003525 Walker B motif; other site 264198003526 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 264198003527 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 264198003528 active site pocket [active] 264198003529 putative dimer interface [polypeptide binding]; other site 264198003530 putative cataytic base [active] 264198003531 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 264198003532 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264198003533 catalytic core [active] 264198003534 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 264198003535 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 264198003536 cobalamin binding residues [chemical binding]; other site 264198003537 putative BtuC binding residues; other site 264198003538 dimer interface [polypeptide binding]; other site 264198003539 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 264198003540 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198003541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198003542 homodimer interface [polypeptide binding]; other site 264198003543 catalytic residue [active] 264198003544 CobD/Cbib protein; Region: CobD_Cbib; cl00561 264198003545 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 264198003546 homotrimer interface [polypeptide binding]; other site 264198003547 Walker A motif; other site 264198003548 GTP binding site [chemical binding]; other site 264198003549 Walker B motif; other site 264198003550 cobyric acid synthase; Provisional; Region: PRK00784 264198003551 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198003552 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198003553 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 264198003554 catalytic triad [active] 264198003555 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264198003556 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 264198003557 Coenzyme A binding pocket [chemical binding]; other site 264198003558 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 264198003559 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 264198003560 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 264198003561 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 264198003562 pantoate--beta-alanine ligase; Region: panC; TIGR00018 264198003563 Pantoate-beta-alanine ligase; Region: PanC; cd00560 264198003564 active site 264198003565 ATP-binding site [chemical binding]; other site 264198003566 pantoate-binding site; other site 264198003567 HXXH motif; other site 264198003568 ScpA/B protein; Region: ScpA_ScpB; cl00598 264198003569 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 264198003570 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 264198003571 Surface antigen; Region: Bac_surface_Ag; cl03097 264198003572 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 264198003573 AsmA-like C-terminal region; Region: AsmA_2; cl15864 264198003574 Family of unknown function (DUF490); Region: DUF490; pfam04357 264198003575 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 264198003576 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 264198003577 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 264198003578 active site 264198003579 HIGH motif; other site 264198003580 KMSKS motif; other site 264198003581 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 264198003582 tRNA binding surface [nucleotide binding]; other site 264198003583 anticodon binding site; other site 264198003584 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 264198003585 dimer interface [polypeptide binding]; other site 264198003586 putative tRNA-binding site [nucleotide binding]; other site 264198003587 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264198003588 ligand binding site [chemical binding]; other site 264198003589 antiporter inner membrane protein; Provisional; Region: PRK11670 264198003590 Domain of unknown function DUF59; Region: DUF59; cl00941 264198003591 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 264198003592 Walker A motif; other site 264198003593 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 264198003594 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 264198003595 DMSO reductase family type II enzyme, iron-sulfur subunit; Region: DMSO_red_II_bet; TIGR03478 264198003596 4Fe-4S binding domain; Region: Fer4; cl02805 264198003597 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 264198003598 4Fe-4S binding domain; Region: Fer4; cl02805 264198003599 4Fe-4S binding domain; Region: Fer4; cl02805 264198003600 hydrogenase 4 subunit H; Validated; Region: PRK08222 264198003601 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 264198003602 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 264198003603 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 264198003604 [4Fe-4S] binding site [ion binding]; other site 264198003605 molybdopterin cofactor binding site; other site 264198003606 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 264198003607 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 264198003608 molybdopterin cofactor binding site; other site 264198003609 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 264198003610 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 264198003611 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 264198003612 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 264198003613 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 264198003614 trimer interface [polypeptide binding]; other site 264198003615 active site 264198003616 arginine decarboxylase; Provisional; Region: PRK15029 264198003617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 264198003618 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264198003619 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264198003620 catalytic residue [active] 264198003621 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 264198003622 Sulfate transporter family; Region: Sulfate_transp; cl15842 264198003623 high affinity sulphate transporter 1; Region: sulP; TIGR00815 264198003624 Sulfate transporter family; Region: Sulfate_transp; cl15842 264198003625 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 264198003626 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 264198003627 putative ADP-binding pocket [chemical binding]; other site 264198003628 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 264198003629 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 264198003630 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 264198003631 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 264198003632 argininosuccinate lyase; Provisional; Region: PRK00855 264198003633 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 264198003634 active sites [active] 264198003635 tetramer interface [polypeptide binding]; other site 264198003636 Anti-sigma-K factor rskA; Region: RskA; pfam10099 264198003637 RNA polymerase sigma factor; Provisional; Region: PRK12514 264198003638 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264198003639 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264198003640 DNA binding residues [nucleotide binding] 264198003641 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 264198003642 dinuclear metal binding motif [ion binding]; other site 264198003643 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 264198003644 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 264198003645 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 264198003646 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 264198003647 domain interfaces; other site 264198003648 active site 264198003649 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 264198003650 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 264198003651 active site 264198003652 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 264198003653 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 264198003654 HemY protein N-terminus; Region: HemY_N; pfam07219 264198003655 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 264198003656 DNA photolyase; Region: DNA_photolyase; pfam00875 264198003657 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 264198003658 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 264198003659 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264198003660 RNA binding surface [nucleotide binding]; other site 264198003661 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 264198003662 active site 264198003663 uracil binding [chemical binding]; other site 264198003664 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 264198003665 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 264198003666 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264198003667 active site 264198003668 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 264198003669 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 264198003670 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198003671 dihydroorotase; Provisional; Region: PRK07627 264198003672 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198003673 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 264198003674 active site 264198003675 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 264198003676 putative acyl-acceptor binding pocket; other site 264198003677 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 264198003678 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 264198003679 active site 264198003680 metal binding site [ion binding]; metal-binding site 264198003681 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 264198003682 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 264198003683 NAD binding site [chemical binding]; other site 264198003684 substrate binding site [chemical binding]; other site 264198003685 homodimer interface [polypeptide binding]; other site 264198003686 active site 264198003687 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 264198003688 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 264198003689 NADP binding site [chemical binding]; other site 264198003690 active site 264198003691 putative substrate binding site [chemical binding]; other site 264198003692 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 264198003693 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 264198003694 substrate binding site; other site 264198003695 tetramer interface; other site 264198003696 Cupin domain; Region: Cupin_2; cl09118 264198003697 ABC-2 type transporter; Region: ABC2_membrane; cl11417 264198003698 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 264198003699 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 264198003700 Walker A/P-loop; other site 264198003701 ATP binding site [chemical binding]; other site 264198003702 Q-loop/lid; other site 264198003703 ABC transporter signature motif; other site 264198003704 Walker B; other site 264198003705 D-loop; other site 264198003706 H-loop/switch region; other site 264198003707 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 264198003708 putative carbohydrate binding site [chemical binding]; other site 264198003709 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198003710 S-adenosylmethionine binding site [chemical binding]; other site 264198003711 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 264198003712 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 264198003713 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 264198003714 Probable Catalytic site; other site 264198003715 metal-binding site 264198003716 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 264198003717 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264198003718 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 264198003719 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 264198003720 NADP-binding site; other site 264198003721 homotetramer interface [polypeptide binding]; other site 264198003722 substrate binding site [chemical binding]; other site 264198003723 homodimer interface [polypeptide binding]; other site 264198003724 active site 264198003725 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 264198003726 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 264198003727 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 264198003728 dimer interface [polypeptide binding]; other site 264198003729 active site 264198003730 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 264198003731 Substrate binding site; other site 264198003732 Mg++ binding site; other site 264198003733 metal-binding site 264198003734 Mg++ binding site; other site 264198003735 metal-binding site 264198003736 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 264198003737 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264198003738 active site 264198003739 motif I; other site 264198003740 motif II; other site 264198003741 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264198003742 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 264198003743 Mg++ binding site [ion binding]; other site 264198003744 putative catalytic motif [active] 264198003745 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 264198003746 Ligand binding site; other site 264198003747 Putative Catalytic site; other site 264198003748 DXD motif; other site 264198003749 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 264198003750 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264198003751 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 264198003752 Ligand binding site; other site 264198003753 OpgC protein; Region: OpgC_C; cl00792 264198003754 Acyltransferase family; Region: Acyl_transf_3; pfam01757 264198003755 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 264198003756 AAA domain; Region: AAA_33; pfam13671 264198003757 ligand-binding site [chemical binding]; other site 264198003758 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 264198003759 putative ADP-binding pocket [chemical binding]; other site 264198003760 MatE; Region: MatE; cl10513 264198003761 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264198003762 This family is most closely related to the GT1 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor...; Region: GT1_WbdM_like; cd04951 264198003763 Bacterial sugar transferase; Region: Bac_transf; cl00939 264198003764 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264198003765 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 264198003766 putative ADP-binding pocket [chemical binding]; other site 264198003767 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 264198003768 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 264198003769 active site 264198003770 substrate binding site [chemical binding]; other site 264198003771 metal binding site [ion binding]; metal-binding site 264198003772 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 264198003773 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 264198003774 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 264198003775 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 264198003776 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 264198003777 META domain; Region: META; cl01245 264198003778 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 264198003779 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 264198003780 Member of the Rhodanese Homology Domain superfamily, subgroup 2. Subgroup 2 includes uncharacterized putative rhodanese-related domains; Region: RHOD_2; cd01528 264198003781 active site residue [active] 264198003782 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 264198003783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198003784 S-adenosylmethionine binding site [chemical binding]; other site 264198003785 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 264198003786 Protein export membrane protein; Region: SecD_SecF; cl14618 264198003787 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 264198003788 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264198003789 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198003790 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198003791 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198003792 Helix-turn-helix domains; Region: HTH; cl00088 264198003793 Protein of unknown function (DUF1439); Region: DUF1439; cl06345 264198003794 Bacitracin resistance protein BacA; Region: BacA; cl00858 264198003795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 264198003796 O-Antigen ligase; Region: Wzy_C; cl04850 264198003797 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 264198003798 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 264198003799 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 264198003800 active site 264198003801 catalytic residues [active] 264198003802 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 264198003803 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 264198003804 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 264198003805 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264198003806 putative C-terminal domain interface [polypeptide binding]; other site 264198003807 putative GSH binding site (G-site) [chemical binding]; other site 264198003808 putative dimer interface [polypeptide binding]; other site 264198003809 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 264198003810 putative N-terminal domain interface [polypeptide binding]; other site 264198003811 putative dimer interface [polypeptide binding]; other site 264198003812 putative substrate binding pocket (H-site) [chemical binding]; other site 264198003813 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 264198003814 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 264198003815 AMP-binding enzyme; Region: AMP-binding; cl15778 264198003816 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 264198003817 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 264198003818 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264198003819 catalytic residue [active] 264198003820 aminotransferase; Validated; Region: PRK07337 264198003821 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198003822 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198003823 homodimer interface [polypeptide binding]; other site 264198003824 catalytic residue [active] 264198003825 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 264198003826 putative RNA binding site [nucleotide binding]; other site 264198003827 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 264198003828 homopentamer interface [polypeptide binding]; other site 264198003829 active site 264198003830 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 264198003831 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 264198003832 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 264198003833 dimerization interface [polypeptide binding]; other site 264198003834 active site 264198003835 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198003836 putative CheW interface [polypeptide binding]; other site 264198003837 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 264198003838 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264198003839 TPR motif; other site 264198003840 binding surface 264198003841 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 264198003842 Lumazine binding domain; Region: Lum_binding; pfam00677 264198003843 Lumazine binding domain; Region: Lum_binding; pfam00677 264198003844 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 264198003845 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 264198003846 catalytic motif [active] 264198003847 Zn binding site [ion binding]; other site 264198003848 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 264198003849 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 264198003850 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 264198003851 Type II transport protein GspH; Region: GspH; pfam12019 264198003852 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 264198003853 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 264198003854 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 264198003855 Type IV pilus assembly protein PilX C-term; Region: PilX; pfam13681 264198003856 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 264198003857 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 264198003858 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 264198003859 Type II transport protein GspH; Region: GspH; pfam12019 264198003860 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 264198003861 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 264198003862 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 264198003863 PilX N-terminal; Region: PilX_N; pfam14341 264198003864 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 264198003865 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 264198003866 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 264198003867 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 264198003868 ATP cone domain; Region: ATP-cone; pfam03477 264198003869 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 264198003870 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 264198003871 dimer interface [polypeptide binding]; other site 264198003872 active site 264198003873 glycine-pyridoxal phosphate binding site [chemical binding]; other site 264198003874 folate binding site [chemical binding]; other site 264198003875 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 264198003876 active site 264198003877 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 264198003878 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 264198003879 Gram-negative bacterial tonB protein; Region: TonB; cl10048 264198003880 translocation protein TolB; Provisional; Region: tolB; PRK02889 264198003881 TolB amino-terminal domain; Region: TolB_N; cl00639 264198003882 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 264198003883 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 264198003884 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 264198003885 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 264198003886 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264198003887 ligand binding site [chemical binding]; other site 264198003888 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 264198003889 Tetratricopeptide repeat; Region: TPR_6; pfam13174 264198003890 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 264198003891 Ligand Binding Site [chemical binding]; other site 264198003892 Predicted transporter component [General function prediction only]; Region: COG2391 264198003893 Sulphur transport; Region: Sulf_transp; cl01018 264198003894 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198003895 putative active site [active] 264198003896 heme pocket [chemical binding]; other site 264198003897 PAS fold; Region: PAS; pfam00989 264198003898 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198003899 putative active site [active] 264198003900 heme pocket [chemical binding]; other site 264198003901 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198003902 metal binding site [ion binding]; metal-binding site 264198003903 active site 264198003904 I-site; other site 264198003905 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264198003906 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 264198003907 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 264198003908 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 264198003909 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 264198003910 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198003911 FAD binding site [chemical binding]; other site 264198003912 substrate binding pocket [chemical binding]; other site 264198003913 catalytic base [active] 264198003914 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198003915 Helix-turn-helix domains; Region: HTH; cl00088 264198003916 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 264198003917 kynureninase; Region: kynureninase; TIGR01814 264198003918 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264198003919 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264198003920 catalytic residue [active] 264198003921 Putative cyclase; Region: Cyclase; cl00814 264198003922 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264198003923 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264198003924 putative DNA binding site [nucleotide binding]; other site 264198003925 putative Zn2+ binding site [ion binding]; other site 264198003926 AsnC family; Region: AsnC_trans_reg; pfam01037 264198003927 Flavin Reductases; Region: FlaRed; cl00801 264198003928 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 264198003929 Protein of unknown function DUF72; Region: DUF72; cl00777 264198003930 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 264198003931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198003932 S-adenosylmethionine binding site [chemical binding]; other site 264198003933 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 264198003934 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 264198003935 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 264198003936 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198003937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198003938 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 264198003939 AsmA-like C-terminal region; Region: AsmA_2; cl15864 264198003940 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 264198003941 putative ATP binding site [chemical binding]; other site 264198003942 putative substrate interface [chemical binding]; other site 264198003943 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198003944 AAA domain; Region: AAA_33; pfam13671 264198003945 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198003946 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 264198003947 Cupin domain; Region: Cupin_2; cl09118 264198003948 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 264198003949 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 264198003950 catalytic residues [active] 264198003951 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 264198003952 AMP-binding enzyme; Region: AMP-binding; cl15778 264198003953 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198003954 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 264198003955 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 264198003956 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 264198003957 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 264198003958 putative active site pocket [active] 264198003959 dimerization interface [polypeptide binding]; other site 264198003960 putative catalytic residue [active] 264198003961 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 264198003962 YaeQ protein; Region: YaeQ; cl01913 264198003963 YceI-like domain; Region: YceI; cl01001 264198003964 MAPEG family; Region: MAPEG; cl09190 264198003965 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 264198003966 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 264198003967 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264198003968 active site 264198003969 HIGH motif; other site 264198003970 nucleotide binding site [chemical binding]; other site 264198003971 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 264198003972 KMSKS motif; other site 264198003973 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 264198003974 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198003975 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198003976 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 264198003977 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 264198003978 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 264198003979 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 264198003980 PapC N-terminal domain; Region: PapC_N; pfam13954 264198003981 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 264198003982 PapC C-terminal domain; Region: PapC_C; pfam13953 264198003983 putative chaperone protein EcpD; Provisional; Region: PRK09926 264198003984 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 264198003985 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 264198003986 Fimbrial protein; Region: Fimbrial; cl01416 264198003987 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 264198003988 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 264198003989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198003990 NMT1-like family; Region: NMT1_2; cl15260 264198003991 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198003992 Helix-turn-helix domains; Region: HTH; cl00088 264198003993 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198003994 dimerization interface [polypeptide binding]; other site 264198003995 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 264198003996 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 264198003997 potassium/proton antiporter; Reviewed; Region: PRK05326 264198003998 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 264198003999 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 264198004000 Transporter associated domain; Region: CorC_HlyC; cl08393 264198004001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198004002 NMT1-like family; Region: NMT1_2; cl15260 264198004003 Predicted membrane protein (DUF2214); Region: DUF2214; cl01427 264198004004 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198004005 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198004006 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 264198004007 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 264198004008 motif 1; other site 264198004009 active site 264198004010 motif 2; other site 264198004011 motif 3; other site 264198004012 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 264198004013 DHHA1 domain; Region: DHHA1; pfam02272 264198004014 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 264198004015 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 264198004016 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 264198004017 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 264198004018 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 264198004019 dimer interface [polypeptide binding]; other site 264198004020 active site residues [active] 264198004021 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 264198004022 Helix-turn-helix domains; Region: HTH; cl00088 264198004023 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198004024 dimerization interface [polypeptide binding]; other site 264198004025 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 264198004026 active site 1 [active] 264198004027 dimer interface [polypeptide binding]; other site 264198004028 hexamer interface [polypeptide binding]; other site 264198004029 active site 2 [active] 264198004030 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 264198004031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198004032 putative substrate translocation pore; other site 264198004033 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 264198004034 intersubunit interface [polypeptide binding]; other site 264198004035 active site 264198004036 Zn2+ binding site [ion binding]; other site 264198004037 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 264198004038 active site 1 [active] 264198004039 dimer interface [polypeptide binding]; other site 264198004040 hexamer interface [polypeptide binding]; other site 264198004041 active site 2 [active] 264198004042 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 264198004043 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 264198004044 tetramer interface [polypeptide binding]; other site 264198004045 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198004046 catalytic residue [active] 264198004047 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 264198004048 nudix motif; other site 264198004049 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 264198004050 CPxP motif; other site 264198004051 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 264198004052 active site 264198004053 tetramer interface; other site 264198004054 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 264198004055 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 264198004056 HIGH motif; other site 264198004057 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 264198004058 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 264198004059 active site 264198004060 KMSKS motif; other site 264198004061 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 264198004062 tRNA binding surface [nucleotide binding]; other site 264198004063 anticodon binding site; other site 264198004064 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 264198004065 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 264198004066 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198004067 Family description; Region: UvrD_C_2; cl15862 264198004068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198004069 D-galactonate transporter; Region: 2A0114; TIGR00893 264198004070 putative substrate translocation pore; other site 264198004071 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 264198004072 AMP-binding enzyme; Region: AMP-binding; cl15778 264198004073 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198004074 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 264198004075 putative catalytic cysteine [active] 264198004076 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198004077 Helix-turn-helix domains; Region: HTH; cl00088 264198004078 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198004079 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 264198004080 Phosphotransferase enzyme family; Region: APH; pfam01636 264198004081 putative active site [active] 264198004082 putative substrate binding site [chemical binding]; other site 264198004083 ATP binding site [chemical binding]; other site 264198004084 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 264198004085 DNA polymerase I; Provisional; Region: PRK05755 264198004086 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 264198004087 active site 264198004088 metal binding site 1 [ion binding]; metal-binding site 264198004089 putative 5' ssDNA interaction site; other site 264198004090 metal binding site 3; metal-binding site 264198004091 metal binding site 2 [ion binding]; metal-binding site 264198004092 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 264198004093 putative DNA binding site [nucleotide binding]; other site 264198004094 putative metal binding site [ion binding]; other site 264198004095 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 264198004096 active site 264198004097 catalytic site [active] 264198004098 substrate binding site [chemical binding]; other site 264198004099 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 264198004100 active site 264198004101 DNA binding site [nucleotide binding] 264198004102 catalytic site [active] 264198004103 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 264198004104 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198004105 Dienelactone hydrolase family; Region: DLH; pfam01738 264198004106 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198004107 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 264198004108 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 264198004109 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 264198004110 active site residue [active] 264198004111 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 264198004112 active site residue [active] 264198004113 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 264198004114 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 264198004115 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 264198004116 [2Fe-2S] cluster binding site [ion binding]; other site 264198004117 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 264198004118 alpha subunit interface [polypeptide binding]; other site 264198004119 active site 264198004120 substrate binding site [chemical binding]; other site 264198004121 Fe binding site [ion binding]; other site 264198004122 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 264198004123 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 264198004124 substrate binding pocket [chemical binding]; other site 264198004125 chain length determination region; other site 264198004126 substrate-Mg2+ binding site; other site 264198004127 catalytic residues [active] 264198004128 aspartate-rich region 1; other site 264198004129 active site lid residues [active] 264198004130 aspartate-rich region 2; other site 264198004131 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 264198004132 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 264198004133 TPP-binding site; other site 264198004134 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 264198004135 PYR/PP interface [polypeptide binding]; other site 264198004136 dimer interface [polypeptide binding]; other site 264198004137 TPP binding site [chemical binding]; other site 264198004138 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 264198004139 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 264198004140 UGMP family protein; Validated; Region: PRK09604 264198004141 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 264198004142 HI0933-like protein; Region: HI0933_like; pfam03486 264198004143 GatB domain; Region: GatB_Yqey; cl11497 264198004144 DNA primase; Validated; Region: dnaG; PRK05667 264198004145 CHC2 zinc finger; Region: zf-CHC2; cl15369 264198004146 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 264198004147 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 264198004148 active site 264198004149 metal binding site [ion binding]; metal-binding site 264198004150 interdomain interaction site; other site 264198004151 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 264198004152 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 264198004153 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 264198004154 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 264198004155 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 264198004156 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 264198004157 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264198004158 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 264198004159 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264198004160 DNA binding residues [nucleotide binding] 264198004161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198004162 metabolite-proton symporter; Region: 2A0106; TIGR00883 264198004163 putative substrate translocation pore; other site 264198004164 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 264198004165 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198004166 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 264198004167 active site 264198004168 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 264198004169 Helix-turn-helix domains; Region: HTH; cl00088 264198004170 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 264198004171 dimerization interface [polypeptide binding]; other site 264198004172 substrate binding pocket [chemical binding]; other site 264198004173 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 264198004174 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198004175 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 264198004176 intersubunit interface [polypeptide binding]; other site 264198004177 active site 264198004178 Zn2+ binding site [ion binding]; other site 264198004179 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264198004180 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198004181 ligand binding site [chemical binding]; other site 264198004182 flexible hinge region; other site 264198004183 Helix-turn-helix domains; Region: HTH; cl00088 264198004184 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 264198004185 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198004186 DNA-binding site [nucleotide binding]; DNA binding site 264198004187 UTRA domain; Region: UTRA; cl01230 264198004188 urocanate hydratase; Provisional; Region: PRK05414 264198004189 citrate-proton symporter; Provisional; Region: PRK15075 264198004190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198004191 putative substrate translocation pore; other site 264198004192 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 264198004193 DEAD-like helicases superfamily; Region: DEXDc; smart00487 264198004194 ATP binding site [chemical binding]; other site 264198004195 Mg++ binding site [ion binding]; other site 264198004196 motif III; other site 264198004197 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264198004198 nucleotide binding region [chemical binding]; other site 264198004199 ATP-binding site [chemical binding]; other site 264198004200 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264198004201 active site 264198004202 HIGH motif; other site 264198004203 nucleotide binding site [chemical binding]; other site 264198004204 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264198004205 active site 264198004206 KMSKS motif; other site 264198004207 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 264198004208 Helix-turn-helix domains; Region: HTH; cl00088 264198004209 The C-terminal substrate binding domain of LysR-type transcriptional regulator, HupR, which regulates expression of the heme uptake receptor HupA; contains the type 2 periplasmic binding fold; Region: PBP2_HupR; cd08431 264198004210 putative dimerization interface [polypeptide binding]; other site 264198004211 Cupin domain; Region: Cupin_2; cl09118 264198004212 CobD/Cbib protein; Region: CobD_Cbib; cl00561 264198004213 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 264198004214 GTPase RsgA; Reviewed; Region: PRK00098 264198004215 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 264198004216 RNA binding site [nucleotide binding]; other site 264198004217 homodimer interface [polypeptide binding]; other site 264198004218 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 264198004219 GTPase/Zn-binding domain interface [polypeptide binding]; other site 264198004220 GTP/Mg2+ binding site [chemical binding]; other site 264198004221 G4 box; other site 264198004222 G5 box; other site 264198004223 G1 box; other site 264198004224 Switch I region; other site 264198004225 G2 box; other site 264198004226 G3 box; other site 264198004227 Switch II region; other site 264198004228 Peptidase family M48; Region: Peptidase_M48; cl12018 264198004229 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 264198004230 catalytic site [active] 264198004231 putative active site [active] 264198004232 putative substrate binding site [chemical binding]; other site 264198004233 dimer interface [polypeptide binding]; other site 264198004234 Membrane transport protein; Region: Mem_trans; cl09117 264198004235 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 264198004236 MPT binding site; other site 264198004237 trimer interface [polypeptide binding]; other site 264198004238 Protein of unknown function (DUF615); Region: DUF615; cl01147 264198004239 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 264198004240 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 264198004241 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 264198004242 folate binding site [chemical binding]; other site 264198004243 NADP+ binding site [chemical binding]; other site 264198004244 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 264198004245 dimerization interface [polypeptide binding]; other site 264198004246 active site 264198004247 Integral membrane protein TerC family; Region: TerC; cl10468 264198004248 probable methyltransferase; Region: TIGR03438 264198004249 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 264198004250 TIGR03440 family protein; Region: unchr_TIGR03440 264198004251 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 264198004252 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 264198004253 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 264198004254 ATP binding site [chemical binding]; other site 264198004255 Mg++ binding site [ion binding]; other site 264198004256 motif III; other site 264198004257 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264198004258 nucleotide binding region [chemical binding]; other site 264198004259 ATP-binding site [chemical binding]; other site 264198004260 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 264198004261 Catalytic domain of Protein Kinases; Region: PKc; cd00180 264198004262 active site 264198004263 ATP binding site [chemical binding]; other site 264198004264 substrate binding site [chemical binding]; other site 264198004265 activation loop (A-loop); other site 264198004266 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 264198004267 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 264198004268 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 264198004269 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 264198004270 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264198004271 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 264198004272 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 264198004273 phosphopeptide binding site; other site 264198004274 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 264198004275 phosphopeptide binding site; other site 264198004276 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 264198004277 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198004278 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198004279 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 264198004280 PPIC-type PPIASE domain; Region: Rotamase; cl08278 264198004281 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198004282 ligand binding site [chemical binding]; other site 264198004283 flexible hinge region; other site 264198004284 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198004285 ligand binding site [chemical binding]; other site 264198004286 flexible hinge region; other site 264198004287 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 264198004288 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39B; cd02418 264198004289 putative active site [active] 264198004290 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 264198004291 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198004292 Walker A/P-loop; other site 264198004293 ATP binding site [chemical binding]; other site 264198004294 Q-loop/lid; other site 264198004295 ABC transporter signature motif; other site 264198004296 Walker B; other site 264198004297 D-loop; other site 264198004298 H-loop/switch region; other site 264198004299 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 264198004300 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198004301 Walker A motif; other site 264198004302 ATP binding site [chemical binding]; other site 264198004303 Walker B motif; other site 264198004304 arginine finger; other site 264198004305 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 264198004306 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198004307 Helix-turn-helix domains; Region: HTH; cl00088 264198004308 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198004309 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 264198004310 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 264198004311 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 264198004312 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 264198004313 apolar tunnel; other site 264198004314 heme binding site [chemical binding]; other site 264198004315 dimerization interface [polypeptide binding]; other site 264198004316 Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561 264198004317 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 264198004318 Helix-turn-helix domains; Region: HTH; cl00088 264198004319 Bacterial transcriptional repressor; Region: TetR; pfam13972 264198004320 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 264198004321 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264198004322 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 264198004323 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264198004324 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 264198004325 putative active site [active] 264198004326 putative metal binding site [ion binding]; other site 264198004327 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264198004328 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198004329 RDD family; Region: RDD; cl00746 264198004330 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 264198004331 Protein of unknown function (DUF3619); Region: DUF3619; pfam12279 264198004332 RNA polymerase factor sigma-70; Validated; Region: PRK09047 264198004333 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264198004334 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264198004335 DNA binding residues [nucleotide binding] 264198004336 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 264198004337 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 264198004338 PYR/PP interface [polypeptide binding]; other site 264198004339 dimer interface [polypeptide binding]; other site 264198004340 TPP binding site [chemical binding]; other site 264198004341 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 264198004342 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 264198004343 TPP-binding site [chemical binding]; other site 264198004344 dimer interface [polypeptide binding]; other site 264198004345 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 264198004346 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 264198004347 putative valine binding site [chemical binding]; other site 264198004348 dimer interface [polypeptide binding]; other site 264198004349 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 264198004350 ketol-acid reductoisomerase; Provisional; Region: PRK05479 264198004351 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198004352 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 264198004353 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 264198004354 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 264198004355 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 264198004356 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 264198004357 BON domain; Region: BON; cl02771 264198004358 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264198004359 2-isopropylmalate synthase; Validated; Region: PRK00915 264198004360 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 264198004361 active site 264198004362 catalytic residues [active] 264198004363 metal binding site [ion binding]; metal-binding site 264198004364 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 264198004365 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198004366 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 264198004367 putative ligand binding site [chemical binding]; other site 264198004368 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 264198004369 16S/18S rRNA binding site [nucleotide binding]; other site 264198004370 S13e-L30e interaction site [polypeptide binding]; other site 264198004371 25S rRNA binding site [nucleotide binding]; other site 264198004372 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 264198004373 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 264198004374 RNase E interface [polypeptide binding]; other site 264198004375 trimer interface [polypeptide binding]; other site 264198004376 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 264198004377 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 264198004378 RNase E interface [polypeptide binding]; other site 264198004379 trimer interface [polypeptide binding]; other site 264198004380 active site 264198004381 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 264198004382 putative nucleic acid binding region [nucleotide binding]; other site 264198004383 G-X-X-G motif; other site 264198004384 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 264198004385 RNA binding site [nucleotide binding]; other site 264198004386 domain interface; other site 264198004387 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 264198004388 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 264198004389 NAD(P) binding site [chemical binding]; other site 264198004390 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 264198004391 substrate binding site [chemical binding]; other site 264198004392 dimer interface [polypeptide binding]; other site 264198004393 catalytic triad [active] 264198004394 Preprotein translocase SecG subunit; Region: SecG; cl09123 264198004395 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 264198004396 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 264198004397 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 264198004398 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 264198004399 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 264198004400 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 264198004401 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 264198004402 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 264198004403 putative dimer interface [polypeptide binding]; other site 264198004404 [2Fe-2S] cluster binding site [ion binding]; other site 264198004405 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 264198004406 SLBB domain; Region: SLBB; pfam10531 264198004407 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 264198004408 NADH dehydrogenase subunit G; Validated; Region: PRK09129 264198004409 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198004410 catalytic loop [active] 264198004411 iron binding site [ion binding]; other site 264198004412 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 264198004413 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 264198004414 NADH dehydrogenase; Region: NADHdh; cl00469 264198004415 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 264198004416 4Fe-4S binding domain; Region: Fer4; cl02805 264198004417 4Fe-4S binding domain; Region: Fer4; cl02805 264198004418 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 264198004419 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 264198004420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 264198004421 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 264198004422 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 264198004423 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 264198004424 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 264198004425 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 264198004426 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 264198004427 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 264198004428 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 264198004429 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 264198004430 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 264198004431 dimer interface [polypeptide binding]; other site 264198004432 ADP-ribose binding site [chemical binding]; other site 264198004433 active site 264198004434 nudix motif; other site 264198004435 metal binding site [ion binding]; metal-binding site 264198004436 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 264198004437 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 264198004438 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 264198004439 FAD binding site [chemical binding]; other site 264198004440 substrate binding site [chemical binding]; other site 264198004441 catalytic base [active] 264198004442 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 264198004443 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198004444 active site 264198004445 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 264198004446 putative active site [active] 264198004447 putative catalytic site [active] 264198004448 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 264198004449 putative active site [active] 264198004450 putative catalytic site [active] 264198004451 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 264198004452 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 264198004453 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 264198004454 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 264198004455 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 264198004456 D-pathway; other site 264198004457 Putative ubiquinol binding site [chemical binding]; other site 264198004458 Low-spin heme (heme b) binding site [chemical binding]; other site 264198004459 Putative water exit pathway; other site 264198004460 Binuclear center (heme o3/CuB) [ion binding]; other site 264198004461 K-pathway; other site 264198004462 Putative proton exit pathway; other site 264198004463 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 264198004464 Subunit I/III interface [polypeptide binding]; other site 264198004465 Subunit III/IV interface [polypeptide binding]; other site 264198004466 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 264198004467 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198004468 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 264198004469 putative ligand binding site [chemical binding]; other site 264198004470 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198004471 TM-ABC transporter signature motif; other site 264198004472 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198004473 TM-ABC transporter signature motif; other site 264198004474 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 264198004475 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 264198004476 Walker A/P-loop; other site 264198004477 ATP binding site [chemical binding]; other site 264198004478 Q-loop/lid; other site 264198004479 ABC transporter signature motif; other site 264198004480 Walker B; other site 264198004481 D-loop; other site 264198004482 H-loop/switch region; other site 264198004483 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 264198004484 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 264198004485 Walker A/P-loop; other site 264198004486 ATP binding site [chemical binding]; other site 264198004487 Q-loop/lid; other site 264198004488 ABC transporter signature motif; other site 264198004489 Walker B; other site 264198004490 D-loop; other site 264198004491 H-loop/switch region; other site 264198004492 UreD urease accessory protein; Region: UreD; cl00530 264198004493 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 264198004494 alpha-gamma subunit interface [polypeptide binding]; other site 264198004495 beta-gamma subunit interface [polypeptide binding]; other site 264198004496 HupE / UreJ protein; Region: HupE_UreJ; cl01011 264198004497 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 264198004498 gamma-beta subunit interface [polypeptide binding]; other site 264198004499 alpha-beta subunit interface [polypeptide binding]; other site 264198004500 urease subunit alpha; Reviewed; Region: ureC; PRK13207 264198004501 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 264198004502 subunit interactions [polypeptide binding]; other site 264198004503 active site 264198004504 flap region; other site 264198004505 urease accessory protein UreE; Provisional; Region: ureE; PRK13263 264198004506 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 264198004507 dimer interface [polypeptide binding]; other site 264198004508 catalytic residues [active] 264198004509 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 264198004510 UreF; Region: UreF; pfam01730 264198004511 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198004512 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264198004513 non-specific DNA binding site [nucleotide binding]; other site 264198004514 salt bridge; other site 264198004515 sequence-specific DNA binding site [nucleotide binding]; other site 264198004516 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 264198004517 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 264198004518 C-terminal domain interface [polypeptide binding]; other site 264198004519 GSH binding site (G-site) [chemical binding]; other site 264198004520 dimer interface [polypeptide binding]; other site 264198004521 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 264198004522 N-terminal domain interface [polypeptide binding]; other site 264198004523 putative dimer interface [polypeptide binding]; other site 264198004524 active site 264198004525 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198004526 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 264198004527 FAD binding site [chemical binding]; other site 264198004528 substrate binding site [chemical binding]; other site 264198004529 catalytic base [active] 264198004530 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 264198004531 Helix-turn-helix domains; Region: HTH; cl00088 264198004532 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 264198004533 substrate binding pocket [chemical binding]; other site 264198004534 dimerization interface [polypeptide binding]; other site 264198004535 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 264198004536 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 264198004537 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 264198004538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198004539 NMT1-like family; Region: NMT1_2; cl15260 264198004540 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 264198004541 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 264198004542 putative active site [active] 264198004543 putative substrate binding site [chemical binding]; other site 264198004544 ATP binding site [chemical binding]; other site 264198004545 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264198004546 catalytic core [active] 264198004547 enoyl-CoA hydratase; Provisional; Region: PRK07511 264198004548 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198004549 substrate binding site [chemical binding]; other site 264198004550 oxyanion hole (OAH) forming residues; other site 264198004551 trimer interface [polypeptide binding]; other site 264198004552 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 264198004553 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198004554 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 264198004555 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 264198004556 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264198004557 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 264198004558 C-terminal domain interface [polypeptide binding]; other site 264198004559 GSH binding site (G-site) [chemical binding]; other site 264198004560 dimer interface [polypeptide binding]; other site 264198004561 C-terminal, alpha helical domain of an unknown subfamily 9 of Glutathione S-transferases; Region: GST_C_9; cd10424 264198004562 putative N-terminal domain interface [polypeptide binding]; other site 264198004563 putative dimer interface [polypeptide binding]; other site 264198004564 putative substrate binding pocket (H-site) [chemical binding]; other site 264198004565 methionine aminotransferase; Validated; Region: PRK09082 264198004566 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198004567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198004568 homodimer interface [polypeptide binding]; other site 264198004569 catalytic residue [active] 264198004570 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 264198004571 Protein of unknown function (DUF328); Region: DUF328; cl01143 264198004572 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 264198004573 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 264198004574 putative active site [active] 264198004575 Zn binding site [ion binding]; other site 264198004576 N-formylglutamate amidohydrolase; Region: FGase; cl01522 264198004577 NMT1-like family; Region: NMT1_2; cl15260 264198004578 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 264198004579 Helix-turn-helix domains; Region: HTH; cl00088 264198004580 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 264198004581 dimerization interface [polypeptide binding]; other site 264198004582 substrate binding pocket [chemical binding]; other site 264198004583 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 264198004584 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198004585 putative ligand binding site [chemical binding]; other site 264198004586 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 264198004587 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 264198004588 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 264198004589 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198004590 Walker A motif; other site 264198004591 ATP binding site [chemical binding]; other site 264198004592 Walker B motif; other site 264198004593 arginine finger; other site 264198004594 Cytochrome c; Region: Cytochrom_C; cl11414 264198004595 Cytochrome c; Region: Cytochrom_C; cl11414 264198004596 NeuB family; Region: NeuB; cl00496 264198004597 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 264198004598 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 264198004599 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 264198004600 Predicted amidohydrolase [General function prediction only]; Region: COG0388 264198004601 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 264198004602 putative active site [active] 264198004603 catalytic triad [active] 264198004604 dimer interface [polypeptide binding]; other site 264198004605 Predicted membrane protein [Function unknown]; Region: COG3164 264198004606 AsmA-like C-terminal region; Region: AsmA_2; cl15864 264198004607 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 264198004608 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 264198004609 metal binding triad; other site 264198004610 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 264198004611 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 264198004612 metal binding triad; other site 264198004613 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 264198004614 Rhomboid family; Region: Rhomboid; cl11446 264198004615 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 264198004616 active site 264198004617 catalytic triad [active] 264198004618 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 264198004619 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 264198004620 Walker A/P-loop; other site 264198004621 ATP binding site [chemical binding]; other site 264198004622 Q-loop/lid; other site 264198004623 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 264198004624 ABC transporter signature motif; other site 264198004625 Walker B; other site 264198004626 D-loop; other site 264198004627 H-loop/switch region; other site 264198004628 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 264198004629 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 264198004630 Helix-turn-helix domains; Region: HTH; cl00088 264198004631 ferrochelatase; Reviewed; Region: hemH; PRK00035 264198004632 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 264198004633 C-terminal domain interface [polypeptide binding]; other site 264198004634 active site 264198004635 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 264198004636 active site 264198004637 N-terminal domain interface [polypeptide binding]; other site 264198004638 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264198004639 RNA binding surface [nucleotide binding]; other site 264198004640 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 264198004641 dimer interface [polypeptide binding]; other site 264198004642 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 264198004643 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 264198004644 catalytic residues [active] 264198004645 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 264198004646 dimerization interface [polypeptide binding]; other site 264198004647 substrate binding site [chemical binding]; other site 264198004648 active site 264198004649 calcium binding site [ion binding]; other site 264198004650 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 264198004651 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 264198004652 putative FMN binding site [chemical binding]; other site 264198004653 endonuclease III; Provisional; Region: PRK10702 264198004654 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 264198004655 minor groove reading motif; other site 264198004656 helix-hairpin-helix signature motif; other site 264198004657 substrate binding pocket [chemical binding]; other site 264198004658 active site 264198004659 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 264198004660 ferredoxin; Provisional; Region: PRK06991 264198004661 Putative Fe-S cluster; Region: FeS; pfam04060 264198004662 4Fe-4S binding domain; Region: Fer4; cl02805 264198004663 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 264198004664 Helix-turn-helix domains; Region: HTH; cl00088 264198004665 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 264198004666 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 264198004667 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 264198004668 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198004669 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198004670 homodimer interface [polypeptide binding]; other site 264198004671 catalytic residue [active] 264198004672 excinuclease ABC subunit B; Provisional; Region: PRK05298 264198004673 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264198004674 ATP binding site [chemical binding]; other site 264198004675 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264198004676 nucleotide binding region [chemical binding]; other site 264198004677 ATP-binding site [chemical binding]; other site 264198004678 Ultra-violet resistance protein B; Region: UvrB; pfam12344 264198004679 UvrB/uvrC motif; Region: UVR; pfam02151 264198004680 Site-specific recombinase; Region: SpecificRecomb; cl15411 264198004681 Helix-turn-helix domains; Region: HTH; cl00088 264198004682 Rrf2 family protein; Region: rrf2_super; TIGR00738 264198004683 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264198004684 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 264198004685 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264198004686 catalytic residue [active] 264198004687 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 264198004688 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 264198004689 trimerization site [polypeptide binding]; other site 264198004690 active site 264198004691 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 264198004692 Protein of unknown function (DUF3565); Region: DUF3565; pfam12088 264198004693 co-chaperone HscB; Provisional; Region: hscB; PRK03578 264198004694 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 264198004695 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 264198004696 chaperone protein HscA; Provisional; Region: hscA; PRK05183 264198004697 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 264198004698 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198004699 catalytic loop [active] 264198004700 iron binding site [ion binding]; other site 264198004701 Iron-sulphur cluster assembly; Region: Fe-S_assembly; cl01123 264198004702 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 264198004703 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 264198004704 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 264198004705 Similar in sequence to NatA, this is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled to proton or K+ uptake. NatB possess six putative...; Region: ABC_NatA_like; cd03267 264198004706 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 264198004707 Walker A/P-loop; other site 264198004708 ATP binding site [chemical binding]; other site 264198004709 Q-loop/lid; other site 264198004710 ABC transporter signature motif; other site 264198004711 Walker B; other site 264198004712 D-loop; other site 264198004713 H-loop/switch region; other site 264198004714 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 264198004715 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 264198004716 dimer interface [polypeptide binding]; other site 264198004717 putative anticodon binding site; other site 264198004718 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 264198004719 motif 1; other site 264198004720 active site 264198004721 motif 2; other site 264198004722 motif 3; other site 264198004723 short chain dehydrogenase; Provisional; Region: PRK07023 264198004724 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 264198004725 NADP binding site [chemical binding]; other site 264198004726 homodimer interface [polypeptide binding]; other site 264198004727 active site 264198004728 peptide chain release factor 2; Validated; Region: prfB; PRK00578 264198004729 RF-1 domain; Region: RF-1; cl02875 264198004730 RF-1 domain; Region: RF-1; cl02875 264198004731 autolysin; Reviewed; Region: PRK06347 264198004732 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264198004733 Peptidase family M23; Region: Peptidase_M23; pfam01551 264198004734 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 264198004735 DHH family; Region: DHH; pfam01368 264198004736 DHHA1 domain; Region: DHHA1; pfam02272 264198004737 Sulfatase; Region: Sulfatase; cl10460 264198004738 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 264198004739 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264198004740 FtsX-like permease family; Region: FtsX; cl15850 264198004741 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 264198004742 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 264198004743 Walker A/P-loop; other site 264198004744 ATP binding site [chemical binding]; other site 264198004745 Q-loop/lid; other site 264198004746 ABC transporter signature motif; other site 264198004747 Walker B; other site 264198004748 D-loop; other site 264198004749 H-loop/switch region; other site 264198004750 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 264198004751 active site 264198004752 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 264198004753 ComEC family competence protein; Provisional; Region: PRK11539 264198004754 Competence protein; Region: Competence; cl00471 264198004755 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264198004756 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 264198004757 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 264198004758 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 264198004759 putative active site [active] 264198004760 Dehydratase family; Region: ILVD_EDD; cl00340 264198004761 6-phosphogluconate dehydratase; Region: edd; TIGR01196 264198004762 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 264198004763 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 264198004764 ATP-binding site [chemical binding]; other site 264198004765 Gluconate-6-phosphate binding site [chemical binding]; other site 264198004766 Uncharacterized conserved protein [Function unknown]; Region: COG2308 264198004767 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 264198004768 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 264198004769 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 264198004770 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 264198004771 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 264198004772 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 264198004773 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 264198004774 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264198004775 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 264198004776 CTP synthetase; Validated; Region: pyrG; PRK05380 264198004777 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 264198004778 Catalytic site [active] 264198004779 active site 264198004780 UTP binding site [chemical binding]; other site 264198004781 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 264198004782 active site 264198004783 putative oxyanion hole; other site 264198004784 catalytic triad [active] 264198004785 NeuB family; Region: NeuB; cl00496 264198004786 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 264198004787 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 264198004788 enolase; Provisional; Region: eno; PRK00077 264198004789 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 264198004790 dimer interface [polypeptide binding]; other site 264198004791 metal binding site [ion binding]; metal-binding site 264198004792 substrate binding pocket [chemical binding]; other site 264198004793 Septum formation initiator; Region: DivIC; cl11433 264198004794 Disulfide bond chaperones of the HSP33 family [Posttranslational modification, protein turnover, chaperones]; Region: COG1281 264198004795 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 264198004796 dimerization interface [polypeptide binding]; other site 264198004797 domain crossover interface; other site 264198004798 redox-dependent activation switch; other site 264198004799 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 264198004800 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 264198004801 trimer interface [polypeptide binding]; other site 264198004802 putative metal binding site [ion binding]; other site 264198004803 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 264198004804 dinuclear metal binding motif [ion binding]; other site 264198004805 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 264198004806 AMP-binding enzyme; Region: AMP-binding; cl15778 264198004807 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198004808 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 264198004809 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264198004810 nucleophilic elbow; other site 264198004811 catalytic triad; other site 264198004812 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 264198004813 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198004814 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198004815 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 264198004816 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 264198004817 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 264198004818 active site 264198004819 putative substrate binding region [chemical binding]; other site 264198004820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198004821 S-adenosylmethionine binding site [chemical binding]; other site 264198004822 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 264198004823 dihydrodipicolinate synthase; Region: dapA; TIGR00674 264198004824 dimer interface [polypeptide binding]; other site 264198004825 active site 264198004826 catalytic residue [active] 264198004827 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 264198004828 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 264198004829 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264198004830 Uncharacterized conserved protein [Function unknown]; Region: COG2850 264198004831 JmjC domain, hydroxylase; Region: JmjC; cl15814 264198004832 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 264198004833 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 264198004834 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 264198004835 MutS domain I; Region: MutS_I; pfam01624 264198004836 MutS domain II; Region: MutS_II; pfam05188 264198004837 MutS family domain IV; Region: MutS_IV; pfam05190 264198004838 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 264198004839 Walker A/P-loop; other site 264198004840 ATP binding site [chemical binding]; other site 264198004841 Q-loop/lid; other site 264198004842 ABC transporter signature motif; other site 264198004843 Walker B; other site 264198004844 D-loop; other site 264198004845 H-loop/switch region; other site 264198004846 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198004847 Ligand Binding Site [chemical binding]; other site 264198004848 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 264198004849 Protein of unknown function (DUF465); Region: DUF465; cl01070 264198004850 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 264198004851 active site 264198004852 dimerization interface [polypeptide binding]; other site 264198004853 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 264198004854 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 264198004855 serine O-acetyltransferase; Region: cysE; TIGR01172 264198004856 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 264198004857 trimer interface [polypeptide binding]; other site 264198004858 active site 264198004859 substrate binding site [chemical binding]; other site 264198004860 CoA binding site [chemical binding]; other site 264198004861 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 264198004862 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264198004863 putative active site [active] 264198004864 putative metal binding site [ion binding]; other site 264198004865 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 264198004866 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 264198004867 substrate binding site [chemical binding]; other site 264198004868 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 264198004869 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 264198004870 substrate binding site [chemical binding]; other site 264198004871 Tetratricopeptide repeat; Region: TPR_16; pfam13432 264198004872 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264198004873 TPR motif; other site 264198004874 binding surface 264198004875 TPR repeat; Region: TPR_11; pfam13414 264198004876 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 264198004877 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 264198004878 active site 264198004879 HIGH motif; other site 264198004880 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 264198004881 KMSKS motif; other site 264198004882 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 264198004883 tRNA binding surface [nucleotide binding]; other site 264198004884 anticodon binding site; other site 264198004885 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 264198004886 endonuclease III; Region: ENDO3c; smart00478 264198004887 minor groove reading motif; other site 264198004888 helix-hairpin-helix signature motif; other site 264198004889 substrate binding pocket [chemical binding]; other site 264198004890 active site 264198004891 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 264198004892 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 264198004893 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 264198004894 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 264198004895 Ligand Binding Site [chemical binding]; other site 264198004896 TilS substrate binding domain; Region: TilS; pfam09179 264198004897 B3/4 domain; Region: B3_4; cl11458 264198004898 aspartate kinase; Reviewed; Region: PRK06635 264198004899 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 264198004900 putative nucleotide binding site [chemical binding]; other site 264198004901 putative catalytic residues [active] 264198004902 putative Mg ion binding site [ion binding]; other site 264198004903 putative aspartate binding site [chemical binding]; other site 264198004904 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 264198004905 putative allosteric regulatory site; other site 264198004906 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 264198004907 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 264198004908 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198004909 substrate binding pocket [chemical binding]; other site 264198004910 membrane-bound complex binding site; other site 264198004911 hinge residues; other site 264198004912 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 264198004913 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 264198004914 putative trimer interface [polypeptide binding]; other site 264198004915 putative CoA binding site [chemical binding]; other site 264198004916 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198004917 Helix-turn-helix domains; Region: HTH; cl00088 264198004918 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198004919 dimerization interface [polypeptide binding]; other site 264198004920 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 264198004921 putative FMN binding site [chemical binding]; other site 264198004922 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 264198004923 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198004924 active site 264198004925 metal binding site [ion binding]; metal-binding site 264198004926 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 264198004927 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198004928 putative active site [active] 264198004929 putative metal binding site [ion binding]; other site 264198004930 YCII-related domain; Region: YCII; cl00999 264198004931 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 264198004932 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 264198004933 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 264198004934 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198004935 putative metal binding site [ion binding]; other site 264198004936 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264198004937 dimerization interface [polypeptide binding]; other site 264198004938 putative DNA binding site [nucleotide binding]; other site 264198004939 putative Zn2+ binding site [ion binding]; other site 264198004940 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 264198004941 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198004942 Ligand Binding Site [chemical binding]; other site 264198004943 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198004944 Ligand Binding Site [chemical binding]; other site 264198004945 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198004946 Ligand Binding Site [chemical binding]; other site 264198004947 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 264198004948 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264198004949 Beta-Casp domain; Region: Beta-Casp; cl12567 264198004950 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 264198004951 Response regulator receiver domain; Region: Response_reg; pfam00072 264198004952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198004953 active site 264198004954 phosphorylation site [posttranslational modification] 264198004955 intermolecular recognition site; other site 264198004956 dimerization interface [polypeptide binding]; other site 264198004957 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 264198004958 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198004959 ligand binding site [chemical binding]; other site 264198004960 flexible hinge region; other site 264198004961 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 264198004962 putative switch regulator; other site 264198004963 non-specific DNA interactions [nucleotide binding]; other site 264198004964 DNA binding site [nucleotide binding] 264198004965 sequence specific DNA binding site [nucleotide binding]; other site 264198004966 putative cAMP binding site [chemical binding]; other site 264198004967 Response regulator receiver domain; Region: Response_reg; pfam00072 264198004968 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 264198004969 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 264198004970 putative dimer interface [polypeptide binding]; other site 264198004971 FOG: CBS domain [General function prediction only]; Region: COG0517 264198004972 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 264198004973 BON domain; Region: BON; cl02771 264198004974 BON domain; Region: BON; cl02771 264198004975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 264198004976 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 264198004977 putative FMN binding site [chemical binding]; other site 264198004978 NADPH bind site [chemical binding]; other site 264198004979 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264198004980 active site 264198004981 Rhomboid family; Region: Rhomboid; cl11446 264198004982 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 264198004983 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 264198004984 phosphoenolpyruvate synthase; Validated; Region: PRK06464 264198004985 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 264198004986 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 264198004987 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 264198004988 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 264198004989 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198004990 Ligand Binding Site [chemical binding]; other site 264198004991 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198004992 Ligand Binding Site [chemical binding]; other site 264198004993 GYD domain; Region: GYD; cl01743 264198004994 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 264198004995 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 264198004996 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198004997 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 264198004998 H-NS histone family; Region: Histone_HNS; pfam00816 264198004999 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 264198005000 Periplasmic lysozyme inhibitor, I-type (PliI) and similar proteins; Region: PliI_like; cd09632 264198005001 dimer interface [polypeptide binding]; other site 264198005002 putative inhibitory loop; other site 264198005003 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198005004 trimer interface [polypeptide binding]; other site 264198005005 eyelet of channel; other site 264198005006 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264198005007 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 264198005008 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 264198005009 substrate binding site [chemical binding]; other site 264198005010 FMN-binding domain; Region: FMN_bind; cl01081 264198005011 ApbE family; Region: ApbE; cl00643 264198005012 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001 264198005013 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 264198005014 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 264198005015 active site residue [active] 264198005016 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 264198005017 active site residue [active] 264198005018 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198005019 Ligand Binding Site [chemical binding]; other site 264198005020 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 264198005021 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 264198005022 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264198005023 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264198005024 Cytochrome c [Energy production and conversion]; Region: COG3258 264198005025 Cytochrome c; Region: Cytochrom_C; cl11414 264198005026 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 264198005027 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 264198005028 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198005029 NMT1-like family; Region: NMT1_2; cl15260 264198005030 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198005031 classical (c) SDRs; Region: SDR_c; cd05233 264198005032 NAD(P) binding site [chemical binding]; other site 264198005033 active site 264198005034 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 264198005035 Uncharacterized conserved protein [Function unknown]; Region: COG2128 264198005036 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 264198005037 active site 264198005038 oxalacetate binding site [chemical binding]; other site 264198005039 citrylCoA binding site [chemical binding]; other site 264198005040 coenzyme A binding site [chemical binding]; other site 264198005041 catalytic triad [active] 264198005042 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198005043 classical (c) SDRs; Region: SDR_c; cd05233 264198005044 NAD(P) binding site [chemical binding]; other site 264198005045 active site 264198005046 acyl-CoA synthetase; Validated; Region: PRK06188 264198005047 AMP-binding enzyme; Region: AMP-binding; cl15778 264198005048 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198005049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198005050 NMT1-like family; Region: NMT1_2; cl15260 264198005051 Transcriptional regulators [Transcription]; Region: PurR; COG1609 264198005052 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 264198005053 DNA binding site [nucleotide binding] 264198005054 domain linker motif; other site 264198005055 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_5; cd06281 264198005056 putative dimerization interface [polypeptide binding]; other site 264198005057 putative ligand binding site [chemical binding]; other site 264198005058 DoxX; Region: DoxX; cl00976 264198005059 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 264198005060 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 264198005061 acetate kinase; Region: ackA; TIGR00016 264198005062 Acetokinase family; Region: Acetate_kinase; cl01029 264198005063 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198005064 Ligand Binding Site [chemical binding]; other site 264198005065 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198005066 Ligand Binding Site [chemical binding]; other site 264198005067 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 264198005068 Sulfate transporter family; Region: Sulfate_transp; cl15842 264198005069 high affinity sulphate transporter 1; Region: sulP; TIGR00815 264198005070 Sulfate transporter family; Region: Sulfate_transp; cl15842 264198005071 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 264198005072 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 264198005073 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 264198005074 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198005075 Ligand Binding Site [chemical binding]; other site 264198005076 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 264198005077 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264198005078 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 264198005079 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264198005080 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 264198005081 PAS domain S-box; Region: sensory_box; TIGR00229 264198005082 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198005083 putative active site [active] 264198005084 heme pocket [chemical binding]; other site 264198005085 PAS domain S-box; Region: sensory_box; TIGR00229 264198005086 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198005087 putative active site [active] 264198005088 heme pocket [chemical binding]; other site 264198005089 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 264198005090 Histidine kinase; Region: HisKA_3; pfam07730 264198005091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198005092 ATP binding site [chemical binding]; other site 264198005093 Mg2+ binding site [ion binding]; other site 264198005094 G-X-G motif; other site 264198005095 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198005096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198005097 active site 264198005098 phosphorylation site [posttranslational modification] 264198005099 intermolecular recognition site; other site 264198005100 dimerization interface [polypeptide binding]; other site 264198005101 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198005102 DNA binding residues [nucleotide binding] 264198005103 dimerization interface [polypeptide binding]; other site 264198005104 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 264198005105 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198005106 ligand binding site [chemical binding]; other site 264198005107 flexible hinge region; other site 264198005108 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 264198005109 putative switch regulator; other site 264198005110 non-specific DNA interactions [nucleotide binding]; other site 264198005111 DNA binding site [nucleotide binding] 264198005112 sequence specific DNA binding site [nucleotide binding]; other site 264198005113 putative cAMP binding site [chemical binding]; other site 264198005114 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198005115 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 264198005116 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 264198005117 putative dimer interface [polypeptide binding]; other site 264198005118 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 264198005119 BON domain; Region: BON; cl02771 264198005120 BON domain; Region: BON; cl02771 264198005121 BON domain; Region: BON; cl02771 264198005122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 264198005123 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 264198005124 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264198005125 FtsX-like permease family; Region: FtsX; cl15850 264198005126 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 264198005127 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 264198005128 Walker A/P-loop; other site 264198005129 ATP binding site [chemical binding]; other site 264198005130 Q-loop/lid; other site 264198005131 ABC transporter signature motif; other site 264198005132 Walker B; other site 264198005133 D-loop; other site 264198005134 H-loop/switch region; other site 264198005135 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264198005136 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198005137 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198005138 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264198005139 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 264198005140 BON domain; Region: BON; cl02771 264198005141 BON domain; Region: BON; cl02771 264198005142 BON domain; Region: BON; cl02771 264198005143 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 264198005144 putative FMN binding site [chemical binding]; other site 264198005145 NADPH bind site [chemical binding]; other site 264198005146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 264198005147 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198005148 AAA domain; Region: AAA_33; pfam13671 264198005149 active site 264198005150 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 264198005151 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 264198005152 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264198005153 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264198005154 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 264198005155 BON domain; Region: BON; cl02771 264198005156 Protein required for attachment to host cells; Region: Host_attach; cl02398 264198005157 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 264198005158 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 264198005159 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198005160 Helix-turn-helix domains; Region: HTH; cl00088 264198005161 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198005162 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 264198005163 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 264198005164 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 264198005165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198005166 dimer interface [polypeptide binding]; other site 264198005167 conserved gate region; other site 264198005168 putative PBP binding loops; other site 264198005169 ABC-ATPase subunit interface; other site 264198005170 dipeptide transporter; Provisional; Region: PRK10913 264198005171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198005172 putative PBP binding loops; other site 264198005173 dimer interface [polypeptide binding]; other site 264198005174 ABC-ATPase subunit interface; other site 264198005175 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 264198005176 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 264198005177 Walker A/P-loop; other site 264198005178 ATP binding site [chemical binding]; other site 264198005179 Q-loop/lid; other site 264198005180 ABC transporter signature motif; other site 264198005181 Walker B; other site 264198005182 D-loop; other site 264198005183 H-loop/switch region; other site 264198005184 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 264198005185 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 264198005186 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 264198005187 Walker A/P-loop; other site 264198005188 ATP binding site [chemical binding]; other site 264198005189 Q-loop/lid; other site 264198005190 ABC transporter signature motif; other site 264198005191 Walker B; other site 264198005192 D-loop; other site 264198005193 H-loop/switch region; other site 264198005194 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 264198005195 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198005196 eyelet of channel; other site 264198005197 trimer interface [polypeptide binding]; other site 264198005198 N-formylglutamate amidohydrolase; Region: FGase; cl01522 264198005199 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 264198005200 FAD binding domain; Region: FAD_binding_4; pfam01565 264198005201 Predicted membrane protein (DUF2069); Region: DUF2069; cl01299 264198005202 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 264198005203 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 264198005204 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 264198005205 Protein of unknown function (DUF962); Region: DUF962; cl01879 264198005206 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264198005207 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198005208 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198005209 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134 264198005210 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 264198005211 homodimer interface [polypeptide binding]; other site 264198005212 substrate-cofactor binding pocket; other site 264198005213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198005214 catalytic residue [active] 264198005215 FOG: CBS domain [General function prediction only]; Region: COG0517 264198005216 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_12; cd04625 264198005217 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198005218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198005219 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 264198005220 putative acyl-acceptor binding pocket; other site 264198005221 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 264198005222 putative C-terminal domain interface [polypeptide binding]; other site 264198005223 putative GSH binding site [chemical binding]; other site 264198005224 putative dimer interface [polypeptide binding]; other site 264198005225 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 264198005226 putative N-terminal domain interface [polypeptide binding]; other site 264198005227 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 264198005228 Tetramer interface [polypeptide binding]; other site 264198005229 active site 264198005230 FMN-binding site [chemical binding]; other site 264198005231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198005232 putative substrate translocation pore; other site 264198005233 Predicted dehydrogenase [General function prediction only]; Region: COG0579 264198005234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198005235 Transcriptional regulators [Transcription]; Region: FadR; COG2186 264198005236 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198005237 DNA-binding site [nucleotide binding]; DNA binding site 264198005238 FCD domain; Region: FCD; cl11656 264198005239 Flagellar protein YcgR; Region: YcgR_2; pfam12945 264198005240 PilZ domain; Region: PilZ; cl01260 264198005241 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198005242 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 264198005243 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 264198005244 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 264198005245 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 264198005246 classical (c) SDRs; Region: SDR_c; cd05233 264198005247 NAD(P) binding site [chemical binding]; other site 264198005248 active site 264198005249 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 264198005250 DctM-like transporters; Region: DctM; pfam06808 264198005251 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 264198005252 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 264198005253 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 264198005254 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 264198005255 active site 264198005256 PAS domain; Region: PAS_9; pfam13426 264198005257 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198005258 putative active site [active] 264198005259 heme pocket [chemical binding]; other site 264198005260 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198005261 DNA binding residues [nucleotide binding] 264198005262 dimerization interface [polypeptide binding]; other site 264198005263 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 264198005264 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 264198005265 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 264198005266 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 264198005267 NAD binding site [chemical binding]; other site 264198005268 homotetramer interface [polypeptide binding]; other site 264198005269 homodimer interface [polypeptide binding]; other site 264198005270 substrate binding site [chemical binding]; other site 264198005271 active site 264198005272 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198005273 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264198005274 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 264198005275 homotrimer interaction site [polypeptide binding]; other site 264198005276 putative active site [active] 264198005277 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 264198005278 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 264198005279 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 264198005280 synthetase active site [active] 264198005281 NTP binding site [chemical binding]; other site 264198005282 metal binding site [ion binding]; metal-binding site 264198005283 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 264198005284 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 264198005285 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 264198005286 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 264198005287 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 264198005288 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 264198005289 active site 264198005290 dimer interface [polypeptide binding]; other site 264198005291 motif 1; other site 264198005292 motif 2; other site 264198005293 motif 3; other site 264198005294 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 264198005295 anticodon binding site; other site 264198005296 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 264198005297 ribosomal protein L20; Region: rpl20; CHL00068 264198005298 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 264198005299 23S rRNA binding site [nucleotide binding]; other site 264198005300 L21 binding site [polypeptide binding]; other site 264198005301 L13 binding site [polypeptide binding]; other site 264198005302 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 264198005303 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 264198005304 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 264198005305 dimer interface [polypeptide binding]; other site 264198005306 motif 1; other site 264198005307 active site 264198005308 motif 2; other site 264198005309 motif 3; other site 264198005310 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 264198005311 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 264198005312 putative tRNA-binding site [nucleotide binding]; other site 264198005313 B3/4 domain; Region: B3_4; cl11458 264198005314 tRNA synthetase B5 domain; Region: B5; cl08394 264198005315 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 264198005316 dimer interface [polypeptide binding]; other site 264198005317 motif 1; other site 264198005318 motif 3; other site 264198005319 motif 2; other site 264198005320 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 264198005321 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 264198005322 IHF - DNA interface [nucleotide binding]; other site 264198005323 IHF dimer interface [polypeptide binding]; other site 264198005324 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 264198005325 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 264198005326 DNA binding residues [nucleotide binding] 264198005327 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 264198005328 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 264198005329 Helix-turn-helix domains; Region: HTH; cl00088 264198005330 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 264198005331 succinate CoA transferases; Region: YgfH_subfam; TIGR03458 264198005332 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 264198005333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198005334 NMT1-like family; Region: NMT1_2; cl15260 264198005335 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 264198005336 Helix-turn-helix domains; Region: HTH; cl00088 264198005337 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198005338 dimerization interface [polypeptide binding]; other site 264198005339 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 264198005340 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 264198005341 active site 264198005342 putative substrate binding pocket [chemical binding]; other site 264198005343 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 264198005344 Sulfate transporter family; Region: Sulfate_transp; cl15842 264198005345 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 264198005346 Sulfate transporter family; Region: Sulfate_transp; cl15842 264198005347 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 264198005348 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 264198005349 putative catalytic site [active] 264198005350 putative phosphate binding site [ion binding]; other site 264198005351 active site 264198005352 metal binding site A [ion binding]; metal-binding site 264198005353 DNA binding site [nucleotide binding] 264198005354 putative AP binding site [nucleotide binding]; other site 264198005355 putative metal binding site B [ion binding]; other site 264198005356 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 264198005357 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 264198005358 active site 264198005359 Zn binding site [ion binding]; other site 264198005360 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 264198005361 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 264198005362 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 264198005363 homodimer interface [polypeptide binding]; other site 264198005364 NADP binding site [chemical binding]; other site 264198005365 substrate binding site [chemical binding]; other site 264198005366 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 264198005367 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 264198005368 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198005369 active site 264198005370 phosphorylation site [posttranslational modification] 264198005371 intermolecular recognition site; other site 264198005372 dimerization interface [polypeptide binding]; other site 264198005373 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198005374 DNA binding residues [nucleotide binding] 264198005375 dimerization interface [polypeptide binding]; other site 264198005376 PAS domain S-box; Region: sensory_box; TIGR00229 264198005377 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198005378 putative active site [active] 264198005379 heme pocket [chemical binding]; other site 264198005380 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 264198005381 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198005382 dimer interface [polypeptide binding]; other site 264198005383 phosphorylation site [posttranslational modification] 264198005384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198005385 ATP binding site [chemical binding]; other site 264198005386 Mg2+ binding site [ion binding]; other site 264198005387 G-X-G motif; other site 264198005388 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 264198005389 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 264198005390 dimer interface [polypeptide binding]; other site 264198005391 TPP-binding site [chemical binding]; other site 264198005392 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 264198005393 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 264198005394 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 264198005395 E3 interaction surface; other site 264198005396 lipoyl attachment site [posttranslational modification]; other site 264198005397 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 264198005398 E3 interaction surface; other site 264198005399 lipoyl attachment site [posttranslational modification]; other site 264198005400 e3 binding domain; Region: E3_binding; pfam02817 264198005401 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 264198005402 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 264198005403 active site 264198005404 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 264198005405 E3 interaction surface; other site 264198005406 lipoyl attachment site [posttranslational modification]; other site 264198005407 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 264198005408 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198005409 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 264198005410 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 264198005411 FAD binding domain; Region: FAD_binding_4; pfam01565 264198005412 Transcriptional regulators [Transcription]; Region: FadR; COG2186 264198005413 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198005414 DNA-binding site [nucleotide binding]; DNA binding site 264198005415 FCD domain; Region: FCD; cl11656 264198005416 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198005417 Helix-turn-helix domains; Region: HTH; cl00088 264198005418 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198005419 Cysteine-rich domain; Region: CCG; pfam02754 264198005420 Cysteine-rich domain; Region: CCG; pfam02754 264198005421 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 264198005422 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 264198005423 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 264198005424 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 264198005425 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 264198005426 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198005427 Walker A/P-loop; other site 264198005428 ATP binding site [chemical binding]; other site 264198005429 Q-loop/lid; other site 264198005430 ABC transporter signature motif; other site 264198005431 Walker B; other site 264198005432 D-loop; other site 264198005433 H-loop/switch region; other site 264198005434 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 264198005435 TM-ABC transporter signature motif; other site 264198005436 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 264198005437 zinc binding site [ion binding]; other site 264198005438 putative ligand binding site [chemical binding]; other site 264198005439 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 264198005440 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 264198005441 active site 264198005442 catalytic tetrad [active] 264198005443 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 264198005444 quinone interaction residues [chemical binding]; other site 264198005445 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 264198005446 active site 264198005447 catalytic residues [active] 264198005448 FMN binding site [chemical binding]; other site 264198005449 substrate binding site [chemical binding]; other site 264198005450 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 264198005451 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 264198005452 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 264198005453 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 264198005454 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 264198005455 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 264198005456 nudix motif; other site 264198005457 RES domain; Region: RES; cl02411 264198005458 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 264198005459 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 264198005460 4Fe-4S binding domain; Region: Fer4; cl02805 264198005461 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 264198005462 dimerization interface [polypeptide binding]; other site 264198005463 FAD binding pocket [chemical binding]; other site 264198005464 FAD binding motif [chemical binding]; other site 264198005465 catalytic residues [active] 264198005466 NAD binding pocket [chemical binding]; other site 264198005467 phosphate binding motif [ion binding]; other site 264198005468 beta-alpha-beta structure motif; other site 264198005469 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 264198005470 benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184 264198005471 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198005472 substrate binding site [chemical binding]; other site 264198005473 oxyanion hole (OAH) forming residues; other site 264198005474 trimer interface [polypeptide binding]; other site 264198005475 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 264198005476 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264198005477 non-specific DNA binding site [nucleotide binding]; other site 264198005478 salt bridge; other site 264198005479 sequence-specific DNA binding site [nucleotide binding]; other site 264198005480 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 264198005481 ADP binding site [chemical binding]; other site 264198005482 magnesium binding site [ion binding]; other site 264198005483 putative shikimate binding site; other site 264198005484 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 264198005485 AMP-binding enzyme; Region: AMP-binding; cl15778 264198005486 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198005487 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264198005488 Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706 264198005489 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198005490 Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360 264198005491 putative ligand binding site [chemical binding]; other site 264198005492 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198005493 TM-ABC transporter signature motif; other site 264198005494 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198005495 TM-ABC transporter signature motif; other site 264198005496 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198005497 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 264198005498 Walker A/P-loop; other site 264198005499 ATP binding site [chemical binding]; other site 264198005500 Q-loop/lid; other site 264198005501 ABC transporter signature motif; other site 264198005502 Walker B; other site 264198005503 D-loop; other site 264198005504 H-loop/switch region; other site 264198005505 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264198005506 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 264198005507 Walker A/P-loop; other site 264198005508 ATP binding site [chemical binding]; other site 264198005509 Q-loop/lid; other site 264198005510 ABC transporter signature motif; other site 264198005511 Walker B; other site 264198005512 D-loop; other site 264198005513 H-loop/switch region; other site 264198005514 K+ potassium transporter; Region: K_trans; cl15781 264198005515 NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908 264198005516 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 264198005517 NAD binding site [chemical binding]; other site 264198005518 substrate binding site [chemical binding]; other site 264198005519 active site 264198005520 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 264198005521 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 264198005522 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 264198005523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198005524 active site 264198005525 phosphorylation site [posttranslational modification] 264198005526 intermolecular recognition site; other site 264198005527 dimerization interface [polypeptide binding]; other site 264198005528 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198005529 DNA binding site [nucleotide binding] 264198005530 sensor protein QseC; Provisional; Region: PRK10337 264198005531 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198005532 dimer interface [polypeptide binding]; other site 264198005533 phosphorylation site [posttranslational modification] 264198005534 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198005535 ATP binding site [chemical binding]; other site 264198005536 G-X-G motif; other site 264198005537 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 264198005538 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 264198005539 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 264198005540 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 264198005541 RNA binding site [nucleotide binding]; other site 264198005542 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 264198005543 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198005544 DEAD_2; Region: DEAD_2; pfam06733 264198005545 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198005546 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 264198005547 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 264198005548 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264198005549 RNA binding surface [nucleotide binding]; other site 264198005550 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 264198005551 active site 264198005552 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 264198005553 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 264198005554 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 264198005555 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 264198005556 putative acyltransferase; Provisional; Region: PRK05790 264198005557 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264198005558 dimer interface [polypeptide binding]; other site 264198005559 active site 264198005560 acetyacetyl-CoA reductase; Provisional; Region: PRK12938 264198005561 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 264198005562 NAD(P) binding site [chemical binding]; other site 264198005563 homotetramer interface [polypeptide binding]; other site 264198005564 homodimer interface [polypeptide binding]; other site 264198005565 active site 264198005566 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 264198005567 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 264198005568 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 264198005569 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 264198005570 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 264198005571 FMN binding site [chemical binding]; other site 264198005572 active site 264198005573 catalytic residues [active] 264198005574 substrate binding site [chemical binding]; other site 264198005575 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 264198005576 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 264198005577 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264198005578 FeS/SAM binding site; other site 264198005579 TRAM domain; Region: TRAM; cl01282 264198005580 beta-ketothiolase; Provisional; Region: PRK09051 264198005581 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264198005582 dimer interface [polypeptide binding]; other site 264198005583 active site 264198005584 cystathionine beta-lyase; Provisional; Region: PRK07050 264198005585 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264198005586 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264198005587 catalytic residue [active] 264198005588 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 264198005589 Domain of unknown function (DUF4072); Region: DUF4072; pfam13284 264198005590 phosphoserine phosphatase SerB; Region: serB; TIGR00338 264198005591 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264198005592 motif II; other site 264198005593 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 264198005594 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 264198005595 metal binding site [ion binding]; metal-binding site 264198005596 putative dimer interface [polypeptide binding]; other site 264198005597 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 264198005598 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 264198005599 metal binding site [ion binding]; metal-binding site 264198005600 putative dimer interface [polypeptide binding]; other site 264198005601 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 264198005602 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 264198005603 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264198005604 ATP binding site [chemical binding]; other site 264198005605 putative Mg++ binding site [ion binding]; other site 264198005606 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264198005607 nucleotide binding region [chemical binding]; other site 264198005608 ATP-binding site [chemical binding]; other site 264198005609 TRCF domain; Region: TRCF; cl04088 264198005610 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 264198005611 substrate binding site; other site 264198005612 dimer interface; other site 264198005613 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 264198005614 homotrimer interaction site [polypeptide binding]; other site 264198005615 zinc binding site [ion binding]; other site 264198005616 CDP-binding sites; other site 264198005617 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264198005618 Coenzyme A binding pocket [chemical binding]; other site 264198005619 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 264198005620 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 264198005621 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 264198005622 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 264198005623 dimer interface [polypeptide binding]; other site 264198005624 decamer (pentamer of dimers) interface [polypeptide binding]; other site 264198005625 catalytic triad [active] 264198005626 peroxidatic and resolving cysteines [active] 264198005627 citrate-proton symporter; Provisional; Region: PRK15075 264198005628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198005629 putative substrate translocation pore; other site 264198005630 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264198005631 dimerization interface [polypeptide binding]; other site 264198005632 sensory histidine kinase AtoS; Provisional; Region: PRK11360 264198005633 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198005634 ATP binding site [chemical binding]; other site 264198005635 Mg2+ binding site [ion binding]; other site 264198005636 G-X-G motif; other site 264198005637 osmolarity response regulator; Provisional; Region: ompR; PRK09468 264198005638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198005639 active site 264198005640 phosphorylation site [posttranslational modification] 264198005641 intermolecular recognition site; other site 264198005642 dimerization interface [polypeptide binding]; other site 264198005643 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198005644 DNA binding site [nucleotide binding] 264198005645 allantoate amidohydrolase; Reviewed; Region: PRK12893 264198005646 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 264198005647 active site 264198005648 metal binding site [ion binding]; metal-binding site 264198005649 dimer interface [polypeptide binding]; other site 264198005650 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 264198005651 active site lid residues [active] 264198005652 substrate binding pocket [chemical binding]; other site 264198005653 catalytic residues [active] 264198005654 substrate-Mg2+ binding site; other site 264198005655 aspartate-rich region 1; other site 264198005656 aspartate-rich region 2; other site 264198005657 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264198005658 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198005659 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198005660 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 264198005661 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 264198005662 VanZ like family; Region: VanZ; cl01971 264198005663 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 264198005664 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 264198005665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 264198005666 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198005667 trigger factor; Provisional; Region: tig; PRK01490 264198005668 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 264198005669 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 264198005670 Clp protease; Region: CLP_protease; pfam00574 264198005671 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 264198005672 oligomer interface [polypeptide binding]; other site 264198005673 active site residues [active] 264198005674 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 264198005675 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 264198005676 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198005677 Walker A motif; other site 264198005678 ATP binding site [chemical binding]; other site 264198005679 Walker B motif; other site 264198005680 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 264198005681 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 264198005682 Found in ATP-dependent protease La (LON); Region: LON; smart00464 264198005683 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198005684 Walker A motif; other site 264198005685 ATP binding site [chemical binding]; other site 264198005686 Walker B motif; other site 264198005687 arginine finger; other site 264198005688 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 264198005689 SurA N-terminal domain; Region: SurA_N_3; cl07813 264198005690 periplasmic folding chaperone; Provisional; Region: PRK10788 264198005691 PPIC-type PPIASE domain; Region: Rotamase; cl08278 264198005692 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 264198005693 active site 264198005694 catalytic triad [active] 264198005695 oxyanion hole [active] 264198005696 switch loop; other site 264198005697 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 264198005698 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 264198005699 Walker A/P-loop; other site 264198005700 ATP binding site [chemical binding]; other site 264198005701 Q-loop/lid; other site 264198005702 ABC transporter signature motif; other site 264198005703 Walker B; other site 264198005704 D-loop; other site 264198005705 H-loop/switch region; other site 264198005706 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 264198005707 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 264198005708 active site 264198005709 dimer interface [polypeptide binding]; other site 264198005710 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 264198005711 dimer interface [polypeptide binding]; other site 264198005712 active site 264198005713 putative carbohydrate kinase; Provisional; Region: PRK10565 264198005714 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 264198005715 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 264198005716 putative substrate binding site [chemical binding]; other site 264198005717 putative ATP binding site [chemical binding]; other site 264198005718 amidase; Provisional; Region: PRK07056 264198005719 Amidase; Region: Amidase; cl11426 264198005720 Helix-turn-helix domains; Region: HTH; cl00088 264198005721 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 264198005722 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 264198005723 dimerization interface [polypeptide binding]; other site 264198005724 ATP binding site [chemical binding]; other site 264198005725 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 264198005726 dimerization interface [polypeptide binding]; other site 264198005727 ATP binding site [chemical binding]; other site 264198005728 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 264198005729 putative active site [active] 264198005730 catalytic triad [active] 264198005731 peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925 264198005732 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 264198005733 PPIC-type PPIASE domain; Region: Rotamase; cl08278 264198005734 BolA-like protein; Region: BolA; cl00386 264198005735 Intracellular septation protein A; Region: IspA; cl01098 264198005736 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 264198005737 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 264198005738 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 264198005739 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 264198005740 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 264198005741 AMP-binding enzyme; Region: AMP-binding; cl15778 264198005742 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198005743 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198005744 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 264198005745 putative ligand binding site [chemical binding]; other site 264198005746 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198005747 TM-ABC transporter signature motif; other site 264198005748 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198005749 TM-ABC transporter signature motif; other site 264198005750 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198005751 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 264198005752 Walker A/P-loop; other site 264198005753 ATP binding site [chemical binding]; other site 264198005754 Q-loop/lid; other site 264198005755 ABC transporter signature motif; other site 264198005756 Walker B; other site 264198005757 D-loop; other site 264198005758 H-loop/switch region; other site 264198005759 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264198005760 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 264198005761 Walker A/P-loop; other site 264198005762 ATP binding site [chemical binding]; other site 264198005763 Q-loop/lid; other site 264198005764 ABC transporter signature motif; other site 264198005765 Walker B; other site 264198005766 D-loop; other site 264198005767 H-loop/switch region; other site 264198005768 lysine transporter; Provisional; Region: PRK10836 264198005769 Spore germination protein; Region: Spore_permease; cl15802 264198005770 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198005771 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 264198005772 substrate binding site [chemical binding]; other site 264198005773 oxyanion hole (OAH) forming residues; other site 264198005774 trimer interface [polypeptide binding]; other site 264198005775 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198005776 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 264198005777 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 264198005778 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 264198005779 Isochorismatase family; Region: Isochorismatase; pfam00857 264198005780 catalytic triad [active] 264198005781 metal binding site [ion binding]; metal-binding site 264198005782 conserved cis-peptide bond; other site 264198005783 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 264198005784 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264198005785 dimer interface [polypeptide binding]; other site 264198005786 active site 264198005787 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 264198005788 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 264198005789 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 264198005790 FAD binding site [chemical binding]; other site 264198005791 substrate binding site [chemical binding]; other site 264198005792 catalytic residues [active] 264198005793 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 264198005794 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 264198005795 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198005796 NAD(P) binding site [chemical binding]; other site 264198005797 active site 264198005798 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 264198005799 CoenzymeA binding site [chemical binding]; other site 264198005800 subunit interaction site [polypeptide binding]; other site 264198005801 PHB binding site; other site 264198005802 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 264198005803 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 264198005804 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 264198005805 Prostaglandin dehydrogenases; Region: PGDH; cd05288 264198005806 NAD(P) binding site [chemical binding]; other site 264198005807 substrate binding site [chemical binding]; other site 264198005808 dimer interface [polypeptide binding]; other site 264198005809 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 264198005810 intersubunit interface [polypeptide binding]; other site 264198005811 active site 264198005812 Zn2+ binding site [ion binding]; other site 264198005813 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198005814 short chain dehydrogenase; Provisional; Region: PRK06181 264198005815 NAD(P) binding site [chemical binding]; other site 264198005816 active site 264198005817 hypothetical protein; Provisional; Region: PRK06194 264198005818 classical (c) SDRs; Region: SDR_c; cd05233 264198005819 NAD(P) binding site [chemical binding]; other site 264198005820 active site 264198005821 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264198005822 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 264198005823 putative ADP-ribose binding site [chemical binding]; other site 264198005824 putative active site [active] 264198005825 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 264198005826 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 264198005827 putative active site [active] 264198005828 metal binding site [ion binding]; metal-binding site 264198005829 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198005830 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 264198005831 substrate binding pocket [chemical binding]; other site 264198005832 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198005833 NMT1-like family; Region: NMT1_2; cl15260 264198005834 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 264198005835 active site 264198005836 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 264198005837 putative NAD(P) binding site [chemical binding]; other site 264198005838 active site 264198005839 putative substrate binding site [chemical binding]; other site 264198005840 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 264198005841 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 264198005842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198005843 putative substrate translocation pore; other site 264198005844 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 264198005845 intersubunit interface [polypeptide binding]; other site 264198005846 active site 264198005847 Zn2+ binding site [ion binding]; other site 264198005848 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 264198005849 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 264198005850 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198005851 Transcriptional regulators [Transcription]; Region: FadR; COG2186 264198005852 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198005853 DNA-binding site [nucleotide binding]; DNA binding site 264198005854 FCD domain; Region: FCD; cl11656 264198005855 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 264198005856 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 264198005857 NRDE protein; Region: NRDE; cl01315 264198005858 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 264198005859 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 264198005860 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 264198005861 YceG-like family; Region: YceG; pfam02618 264198005862 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 264198005863 dimerization interface [polypeptide binding]; other site 264198005864 thymidylate kinase; Validated; Region: tmk; PRK00698 264198005865 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 264198005866 TMP-binding site; other site 264198005867 ATP-binding site [chemical binding]; other site 264198005868 DNA polymerase III subunit delta'; Validated; Region: PRK06964 264198005869 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198005870 PilZ domain; Region: PilZ; cl01260 264198005871 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 264198005872 active site 264198005873 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 264198005874 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 264198005875 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 264198005876 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 264198005877 TIGR03440 family protein; Region: unchr_TIGR03440 264198005878 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 264198005879 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 264198005880 LysR family transcriptional regulator; Provisional; Region: PRK14997 264198005881 Helix-turn-helix domains; Region: HTH; cl00088 264198005882 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 264198005883 putative effector binding pocket; other site 264198005884 putative dimerization interface [polypeptide binding]; other site 264198005885 DoxX; Region: DoxX; cl00976 264198005886 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 264198005887 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198005888 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 264198005889 Cupin domain; Region: Cupin_2; cl09118 264198005890 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 264198005891 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 264198005892 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 264198005893 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 264198005894 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 264198005895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198005896 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198005897 Helix-turn-helix domains; Region: HTH; cl00088 264198005898 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198005899 NMT1-like family; Region: NMT1_2; cl15260 264198005900 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 264198005901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 264198005902 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 264198005903 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 264198005904 Cytochrome c; Region: Cytochrom_C; cl11414 264198005905 Cytochrome c; Region: Cytochrom_C; cl11414 264198005906 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198005907 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 264198005908 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 264198005909 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 264198005910 putative dimer interface [polypeptide binding]; other site 264198005911 N-terminal domain interface [polypeptide binding]; other site 264198005912 putative substrate binding pocket (H-site) [chemical binding]; other site 264198005913 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 264198005914 putative acyl-acceptor binding pocket; other site 264198005915 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 264198005916 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198005917 Walker A motif; other site 264198005918 ATP binding site [chemical binding]; other site 264198005919 Walker B motif; other site 264198005920 arginine finger; other site 264198005921 Helix-turn-helix domains; Region: HTH; cl00088 264198005922 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198005923 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 264198005924 NAD(P) binding site [chemical binding]; other site 264198005925 catalytic residues [active] 264198005926 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 264198005927 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 264198005928 PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); Region: PQQ_ADH_II; cd10279 264198005929 Trp docking motif [polypeptide binding]; other site 264198005930 cytochrome domain interface [polypeptide binding]; other site 264198005931 active site 264198005932 Cytochrome c; Region: Cytochrom_C; cl11414 264198005933 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 264198005934 active site 264198005935 catalytic residues [active] 264198005936 metal binding site [ion binding]; metal-binding site 264198005937 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 264198005938 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264198005939 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 264198005940 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264198005941 carboxyltransferase (CT) interaction site; other site 264198005942 biotinylation site [posttranslational modification]; other site 264198005943 enoyl-CoA hydratase; Provisional; Region: PRK05995 264198005944 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198005945 substrate binding site [chemical binding]; other site 264198005946 oxyanion hole (OAH) forming residues; other site 264198005947 trimer interface [polypeptide binding]; other site 264198005948 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 264198005949 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 264198005950 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 264198005951 isovaleryl-CoA dehydrogenase; Region: PLN02519 264198005952 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 264198005953 substrate binding site [chemical binding]; other site 264198005954 FAD binding site [chemical binding]; other site 264198005955 catalytic base [active] 264198005956 AMP-binding domain protein; Validated; Region: PRK08315 264198005957 AMP-binding enzyme; Region: AMP-binding; cl15778 264198005958 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198005959 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198005960 Helix-turn-helix domains; Region: HTH; cl00088 264198005961 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 264198005962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198005963 dimer interface [polypeptide binding]; other site 264198005964 conserved gate region; other site 264198005965 putative PBP binding loops; other site 264198005966 ABC-ATPase subunit interface; other site 264198005967 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 264198005968 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 264198005969 Walker A/P-loop; other site 264198005970 ATP binding site [chemical binding]; other site 264198005971 Q-loop/lid; other site 264198005972 ABC transporter signature motif; other site 264198005973 Walker B; other site 264198005974 D-loop; other site 264198005975 H-loop/switch region; other site 264198005976 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 264198005977 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198005978 substrate binding pocket [chemical binding]; other site 264198005979 membrane-bound complex binding site; other site 264198005980 hinge residues; other site 264198005981 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 264198005982 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 264198005983 hydrophobic ligand binding site; other site 264198005984 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 264198005985 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198005986 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 264198005987 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 264198005988 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 264198005989 NADP binding site [chemical binding]; other site 264198005990 dimer interface [polypeptide binding]; other site 264198005991 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 264198005992 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198005993 NAD(P) binding site [chemical binding]; other site 264198005994 catalytic residues [active] 264198005995 transcriptional regulator; Provisional; Region: PRK10632 264198005996 Helix-turn-helix domains; Region: HTH; cl00088 264198005997 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198005998 putative effector binding pocket; other site 264198005999 dimerization interface [polypeptide binding]; other site 264198006000 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 264198006001 [2Fe-2S] cluster binding site [ion binding]; other site 264198006002 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 264198006003 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 264198006004 FMN binding site [chemical binding]; other site 264198006005 substrate binding site [chemical binding]; other site 264198006006 putative catalytic residue [active] 264198006007 YCII-related domain; Region: YCII; cl00999 264198006008 glutathione reductase; Validated; Region: PRK06116 264198006009 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198006010 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 264198006011 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 264198006012 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 264198006013 C-terminal domain interface [polypeptide binding]; other site 264198006014 GSH binding site (G-site) [chemical binding]; other site 264198006015 dimer interface [polypeptide binding]; other site 264198006016 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 264198006017 N-terminal domain interface [polypeptide binding]; other site 264198006018 putative dimer interface [polypeptide binding]; other site 264198006019 active site 264198006020 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264198006021 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 264198006022 putative C-terminal domain interface [polypeptide binding]; other site 264198006023 putative GSH binding site (G-site) [chemical binding]; other site 264198006024 putative dimer interface [polypeptide binding]; other site 264198006025 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 264198006026 putative N-terminal domain interface [polypeptide binding]; other site 264198006027 putative dimer interface [polypeptide binding]; other site 264198006028 putative substrate binding pocket (H-site) [chemical binding]; other site 264198006029 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 264198006030 FOG: CBS domain [General function prediction only]; Region: COG0517 264198006031 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_12; cd04625 264198006032 Cupin domain; Region: Cupin_2; cl09118 264198006033 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270 264198006034 Cupin domain; Region: Cupin_2; cl09118 264198006035 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 264198006036 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 264198006037 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 264198006038 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 264198006039 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 264198006040 active site 264198006041 nucleophile elbow; other site 264198006042 thiamine pyrophosphate protein; Validated; Region: PRK08199 264198006043 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 264198006044 PYR/PP interface [polypeptide binding]; other site 264198006045 dimer interface [polypeptide binding]; other site 264198006046 TPP binding site [chemical binding]; other site 264198006047 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 264198006048 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 264198006049 TPP-binding site [chemical binding]; other site 264198006050 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 264198006051 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 264198006052 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 264198006053 tartronate semialdehyde reductase; Provisional; Region: PRK15059 264198006054 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198006055 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198006056 Helix-turn-helix domains; Region: HTH; cl00088 264198006057 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 264198006058 putative dimerization interface [polypeptide binding]; other site 264198006059 Muconolactone delta-isomerase; Region: MIase; cl01992 264198006060 Methylmuconolactone methyl-isomerase; Region: MmlI; pfam09448 264198006061 benzoate transport; Region: 2A0115; TIGR00895 264198006062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198006063 putative substrate translocation pore; other site 264198006064 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 264198006065 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 264198006066 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198006067 Helix-turn-helix domains; Region: HTH; cl00088 264198006068 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 264198006069 putative dimerization interface [polypeptide binding]; other site 264198006070 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264198006071 Tannase and feruloyl esterase; Region: Tannase; pfam07519 264198006072 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 264198006073 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 264198006074 short chain dehydrogenase; Provisional; Region: PRK07856 264198006075 classical (c) SDRs; Region: SDR_c; cd05233 264198006076 NAD(P) binding site [chemical binding]; other site 264198006077 active site 264198006078 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 264198006079 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198006080 ketosteroid isomerase: Many biological reactions proceed by enzymatic cleavage of a C-H bond adjacent to carbonyl or a carboxyl group, leading to an enol or a enolate intermediate that is subsequently re-protonated at the same or an adjacent carbon; Region: ketosteroid_isomerase; cd00781 264198006081 dimer interface [polypeptide binding]; other site 264198006082 active site/substrate binding site [active] 264198006083 Helix-turn-helix domains; Region: HTH; cl00088 264198006084 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198006085 tropinone reductase; Provisional; Region: PRK09242 264198006086 NAD(P) binding site [chemical binding]; other site 264198006087 active site 264198006088 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 264198006089 putative hydrophobic ligand binding site [chemical binding]; other site 264198006090 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 264198006091 Chromate transporter; Region: Chromate_transp; pfam02417 264198006092 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 264198006093 Chromate transporter; Region: Chromate_transp; pfam02417 264198006094 Chromate resistance exported protein; Region: Chrome_Resist; cl01744 264198006095 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 264198006096 EamA-like transporter family; Region: EamA; cl01037 264198006097 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 264198006098 ArsC family; Region: ArsC; pfam03960 264198006099 catalytic residues [active] 264198006100 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 264198006101 Membrane transport protein; Region: Mem_trans; cl09117 264198006102 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264198006103 putative DNA binding site [nucleotide binding]; other site 264198006104 putative Zn2+ binding site [ion binding]; other site 264198006105 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198006106 DNA binding residues [nucleotide binding] 264198006107 dimerization interface [polypeptide binding]; other site 264198006108 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 264198006109 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 264198006110 CysD dimerization site [polypeptide binding]; other site 264198006111 G1 box; other site 264198006112 putative GEF interaction site [polypeptide binding]; other site 264198006113 GTP/Mg2+ binding site [chemical binding]; other site 264198006114 Switch I region; other site 264198006115 G2 box; other site 264198006116 G3 box; other site 264198006117 Switch II region; other site 264198006118 G4 box; other site 264198006119 G5 box; other site 264198006120 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 264198006121 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 264198006122 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 264198006123 ligand-binding site [chemical binding]; other site 264198006124 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 264198006125 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 264198006126 Active Sites [active] 264198006127 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 264198006128 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198006129 classical (c) SDRs; Region: SDR_c; cd05233 264198006130 NAD(P) binding site [chemical binding]; other site 264198006131 active site 264198006132 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 264198006133 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 264198006134 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 264198006135 dimerization interface [polypeptide binding]; other site 264198006136 active site 264198006137 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 264198006138 hypothetical protein; Provisional; Region: PRK06194 264198006139 classical (c) SDRs; Region: SDR_c; cd05233 264198006140 NAD(P) binding site [chemical binding]; other site 264198006141 active site 264198006142 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 264198006143 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198006144 DNA binding residues [nucleotide binding] 264198006145 dimerization interface [polypeptide binding]; other site 264198006146 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198006147 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 264198006148 active site 264198006149 metal binding site [ion binding]; metal-binding site 264198006150 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 264198006151 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 264198006152 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 264198006153 Flavin binding site [chemical binding]; other site 264198006154 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 264198006155 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198006156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198006157 Flavin Reductases; Region: FlaRed; cl00801 264198006158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198006159 short chain dehydrogenase; Validated; Region: PRK07069 264198006160 NAD(P) binding site [chemical binding]; other site 264198006161 active site 264198006162 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 264198006163 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 264198006164 FAD binding pocket [chemical binding]; other site 264198006165 FAD binding motif [chemical binding]; other site 264198006166 phosphate binding motif [ion binding]; other site 264198006167 beta-alpha-beta structure motif; other site 264198006168 NAD(p) ribose binding residues [chemical binding]; other site 264198006169 NAD binding pocket [chemical binding]; other site 264198006170 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 264198006171 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198006172 catalytic loop [active] 264198006173 iron binding site [ion binding]; other site 264198006174 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 264198006175 AMP-binding enzyme; Region: AMP-binding; cl15778 264198006176 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198006177 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 264198006178 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198006179 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 264198006180 NAD(P) binding site [chemical binding]; other site 264198006181 active site 264198006182 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 264198006183 classical (c) SDRs; Region: SDR_c; cd05233 264198006184 NAD(P) binding site [chemical binding]; other site 264198006185 active site 264198006186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198006187 short chain dehydrogenase; Validated; Region: PRK07069 264198006188 NAD(P) binding site [chemical binding]; other site 264198006189 active site 264198006190 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 264198006191 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198006192 NAD(P) binding site [chemical binding]; other site 264198006193 active site 264198006194 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198006195 classical (c) SDRs; Region: SDR_c; cd05233 264198006196 NAD(P) binding site [chemical binding]; other site 264198006197 active site 264198006198 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198006199 DNA binding residues [nucleotide binding] 264198006200 dimerization interface [polypeptide binding]; other site 264198006201 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 264198006202 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 264198006203 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 264198006204 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 264198006205 active site 264198006206 Fe binding site [ion binding]; other site 264198006207 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 264198006208 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 264198006209 enoyl-CoA hydratase; Provisional; Region: PRK08290 264198006210 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198006211 substrate binding site [chemical binding]; other site 264198006212 oxyanion hole (OAH) forming residues; other site 264198006213 trimer interface [polypeptide binding]; other site 264198006214 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 264198006215 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 264198006216 FMN binding site [chemical binding]; other site 264198006217 substrate binding site [chemical binding]; other site 264198006218 putative catalytic residue [active] 264198006219 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198006220 enoyl-CoA hydratase; Provisional; Region: PRK06495 264198006221 substrate binding site [chemical binding]; other site 264198006222 oxyanion hole (OAH) forming residues; other site 264198006223 trimer interface [polypeptide binding]; other site 264198006224 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198006225 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 264198006226 FAD binding site [chemical binding]; other site 264198006227 substrate binding site [chemical binding]; other site 264198006228 catalytic base [active] 264198006229 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198006230 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 264198006231 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264198006232 dimer interface [polypeptide binding]; other site 264198006233 active site 264198006234 DDE superfamily endonuclease; Region: DDE_4; cl15789 264198006235 DDE superfamily endonuclease; Region: DDE_4; cl15789 264198006236 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198006237 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 264198006238 NAD(P) binding site [chemical binding]; other site 264198006239 active site 264198006240 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198006241 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198006242 active site 264198006243 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 264198006244 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198006245 active site 264198006246 short chain dehydrogenase; Provisional; Region: PRK07831 264198006247 classical (c) SDRs; Region: SDR_c; cd05233 264198006248 NAD(P) binding site [chemical binding]; other site 264198006249 active site 264198006250 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 264198006251 putative active site [active] 264198006252 putative catalytic site [active] 264198006253 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 264198006254 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264198006255 dimer interface [polypeptide binding]; other site 264198006256 active site 264198006257 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 264198006258 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 264198006259 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 264198006260 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 264198006261 active site 264198006262 FMN binding site [chemical binding]; other site 264198006263 substrate binding site [chemical binding]; other site 264198006264 putative catalytic residue [active] 264198006265 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 264198006266 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198006267 classical (c) SDRs; Region: SDR_c; cd05233 264198006268 NAD(P) binding site [chemical binding]; other site 264198006269 active site 264198006270 Cupin domain; Region: Cupin_2; cl09118 264198006271 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198006272 NADH(P)-binding; Region: NAD_binding_10; pfam13460 264198006273 NAD(P) binding site [chemical binding]; other site 264198006274 active site 264198006275 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 264198006276 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198006277 DNA-binding site [nucleotide binding]; DNA binding site 264198006278 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198006279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198006280 homodimer interface [polypeptide binding]; other site 264198006281 catalytic residue [active] 264198006282 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 264198006283 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 264198006284 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 264198006285 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 264198006286 active site 264198006287 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198006288 Helix-turn-helix domains; Region: HTH; cl00088 264198006289 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 264198006290 substrate binding pocket [chemical binding]; other site 264198006291 dimerization interface [polypeptide binding]; other site 264198006292 Flavin Reductases; Region: FlaRed; cl00801 264198006293 4-hydroxyphenylacetate 3-hydroxylase N terminal; Region: HpaB_N; pfam11794 264198006294 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198006295 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 264198006296 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 264198006297 putative FMN binding site [chemical binding]; other site 264198006298 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 264198006299 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 264198006300 dimer interface [polypeptide binding]; other site 264198006301 active site 264198006302 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 264198006303 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 264198006304 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 264198006305 active site 264198006306 dimer interface [polypeptide binding]; other site 264198006307 metal binding site [ion binding]; metal-binding site 264198006308 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 264198006309 Arginase family; Region: Arginase; cl00306 264198006310 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 264198006311 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 264198006312 Walker A/P-loop; other site 264198006313 ATP binding site [chemical binding]; other site 264198006314 Q-loop/lid; other site 264198006315 ABC transporter signature motif; other site 264198006316 Walker B; other site 264198006317 D-loop; other site 264198006318 H-loop/switch region; other site 264198006319 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 264198006320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 264198006321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198006322 putative PBP binding loops; other site 264198006323 dimer interface [polypeptide binding]; other site 264198006324 ABC-ATPase subunit interface; other site 264198006325 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264198006326 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198006327 substrate binding pocket [chemical binding]; other site 264198006328 membrane-bound complex binding site; other site 264198006329 hinge residues; other site 264198006330 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198006331 Helix-turn-helix domains; Region: HTH; cl00088 264198006332 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 264198006333 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 264198006334 NADP binding site [chemical binding]; other site 264198006335 dimer interface [polypeptide binding]; other site 264198006336 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 264198006337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198006338 NMT1-like family; Region: NMT1_2; cl15260 264198006339 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198006340 eyelet of channel; other site 264198006341 trimer interface [polypeptide binding]; other site 264198006342 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 264198006343 classical (c) SDRs; Region: SDR_c; cd05233 264198006344 NAD(P) binding site [chemical binding]; other site 264198006345 active site 264198006346 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 264198006347 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 264198006348 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 264198006349 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 264198006350 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 264198006351 NAD(P) binding site [chemical binding]; other site 264198006352 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 264198006353 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198006354 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 264198006355 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 264198006356 catalytic residues [active] 264198006357 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198006358 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198006359 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198006360 NMT1-like family; Region: NMT1_2; cl15260 264198006361 Helix-turn-helix domains; Region: HTH; cl00088 264198006362 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198006363 dimerization interface [polypeptide binding]; other site 264198006364 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264198006365 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 264198006366 nucleophilic elbow; other site 264198006367 catalytic triad; other site 264198006368 Malonate transporter MadL subunit; Region: MadL; cl04273 264198006369 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 264198006370 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264198006371 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 264198006372 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 264198006373 conserved cys residue [active] 264198006374 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198006375 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 264198006376 active site 264198006377 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 264198006378 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 264198006379 conserved cys residue [active] 264198006380 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198006381 benzoate transport; Region: 2A0115; TIGR00895 264198006382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198006383 putative substrate translocation pore; other site 264198006384 amidase; Provisional; Region: PRK07487 264198006385 Amidase; Region: Amidase; cl11426 264198006386 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 264198006387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198006388 putative substrate translocation pore; other site 264198006389 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 264198006390 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198006391 active site 264198006392 metal binding site [ion binding]; metal-binding site 264198006393 short chain dehydrogenase; Provisional; Region: PRK12937 264198006394 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 264198006395 NADP binding site [chemical binding]; other site 264198006396 homodimer interface [polypeptide binding]; other site 264198006397 active site 264198006398 substrate binding site [chemical binding]; other site 264198006399 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198006400 Helix-turn-helix domains; Region: HTH; cl00088 264198006401 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 264198006402 putative effector binding pocket; other site 264198006403 putative dimerization interface [polypeptide binding]; other site 264198006404 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264198006405 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264198006406 catalytic residue [active] 264198006407 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 264198006408 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 264198006409 Int/Topo IB signature motif; other site 264198006410 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 264198006411 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 264198006412 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 264198006413 HipA N-terminal domain; Region: Couple_hipA; cl11853 264198006414 HipA-like N-terminal domain; Region: HipA_N; pfam07805 264198006415 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 264198006416 HipA-like C-terminal domain; Region: HipA_C; pfam07804 264198006417 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 264198006418 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198006419 Helix-turn-helix domains; Region: HTH; cl00088 264198006420 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 264198006421 putative dimerization interface [polypeptide binding]; other site 264198006422 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 264198006423 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 264198006424 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 264198006425 dimer interface [polypeptide binding]; other site 264198006426 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 264198006427 active site 264198006428 heme binding site [chemical binding]; other site 264198006429 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 264198006430 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 264198006431 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 264198006432 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198006433 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 264198006434 FAD binding domain; Region: FAD_binding_4; pfam01565 264198006435 Berberine and berberine like; Region: BBE; pfam08031 264198006436 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198006437 PAS domain; Region: PAS_9; pfam13426 264198006438 putative active site [active] 264198006439 heme pocket [chemical binding]; other site 264198006440 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198006441 metal binding site [ion binding]; metal-binding site 264198006442 active site 264198006443 I-site; other site 264198006444 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264198006445 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 264198006446 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198006447 Helix-turn-helix domains; Region: HTH; cl00088 264198006448 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 264198006449 putative dimerization interface [polypeptide binding]; other site 264198006450 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 264198006451 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 264198006452 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 264198006453 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 264198006454 metal ion-dependent adhesion site (MIDAS); other site 264198006455 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 264198006456 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 264198006457 putative substrate binding site [chemical binding]; other site 264198006458 putative ATP binding site [chemical binding]; other site 264198006459 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 264198006460 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 264198006461 active site 264198006462 dimer interface [polypeptide binding]; other site 264198006463 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 264198006464 dimer interface [polypeptide binding]; other site 264198006465 active site 264198006466 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 264198006467 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 264198006468 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 264198006469 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 264198006470 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 264198006471 putative ligand binding site [chemical binding]; other site 264198006472 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 264198006473 TM-ABC transporter signature motif; other site 264198006474 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 264198006475 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 264198006476 Walker A/P-loop; other site 264198006477 ATP binding site [chemical binding]; other site 264198006478 Q-loop/lid; other site 264198006479 ABC transporter signature motif; other site 264198006480 Walker B; other site 264198006481 D-loop; other site 264198006482 H-loop/switch region; other site 264198006483 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 264198006484 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 264198006485 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 264198006486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198006487 FAD dependent oxidoreductase; Region: DAO; pfam01266 264198006488 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 264198006489 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198006490 Helix-turn-helix domains; Region: HTH; cl00088 264198006491 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_5; cd08426 264198006492 putative dimerization interface [polypeptide binding]; other site 264198006493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198006494 NMT1-like family; Region: NMT1_2; cl15260 264198006495 amidase; Provisional; Region: PRK07486 264198006496 Amidase; Region: Amidase; cl11426 264198006497 hypothetical protein; Validated; Region: PRK07121 264198006498 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 264198006499 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 264198006500 putative NAD(P) binding site [chemical binding]; other site 264198006501 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 264198006502 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 264198006503 phosphate binding site [ion binding]; other site 264198006504 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 264198006505 substrate binding pocket [chemical binding]; other site 264198006506 active site 264198006507 iron coordination sites [ion binding]; other site 264198006508 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 264198006509 Helix-turn-helix domains; Region: HTH; cl00088 264198006510 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 264198006511 dimerization interface [polypeptide binding]; other site 264198006512 substrate binding pocket [chemical binding]; other site 264198006513 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198006514 NMT1-like family; Region: NMT1_2; cl15260 264198006515 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 264198006516 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 264198006517 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198006518 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198006519 enoyl-CoA hydratase; Provisional; Region: PRK08252 264198006520 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198006521 substrate binding site [chemical binding]; other site 264198006522 oxyanion hole (OAH) forming residues; other site 264198006523 trimer interface [polypeptide binding]; other site 264198006524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198006525 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 264198006526 NAD(P) binding site [chemical binding]; other site 264198006527 active site 264198006528 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 264198006529 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264198006530 dimer interface [polypeptide binding]; other site 264198006531 active site 264198006532 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198006533 Helix-turn-helix domains; Region: HTH; cl00088 264198006534 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198006535 enoyl-CoA hydratase; Provisional; Region: PRK09245 264198006536 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198006537 substrate binding site [chemical binding]; other site 264198006538 oxyanion hole (OAH) forming residues; other site 264198006539 trimer interface [polypeptide binding]; other site 264198006540 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198006541 NMT1-like family; Region: NMT1_2; cl15260 264198006542 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198006543 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198006544 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198006545 NMT1-like family; Region: NMT1_2; cl15260 264198006546 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 264198006547 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 264198006548 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 264198006549 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264198006550 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 264198006551 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 264198006552 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 264198006553 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 264198006554 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 264198006555 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 264198006556 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 264198006557 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 264198006558 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 264198006559 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 264198006560 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 264198006561 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264198006562 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264198006563 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198006564 dimer interface [polypeptide binding]; other site 264198006565 putative CheW interface [polypeptide binding]; other site 264198006566 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264198006567 Coenzyme A binding pocket [chemical binding]; other site 264198006568 2-isopropylmalate synthase; Validated; Region: PRK03739 264198006569 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 264198006570 active site 264198006571 catalytic residues [active] 264198006572 metal binding site [ion binding]; metal-binding site 264198006573 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 264198006574 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 264198006575 Helix-turn-helix domains; Region: HTH; cl00088 264198006576 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 264198006577 dimerizarion interface [polypeptide binding]; other site 264198006578 CrgA pocket; other site 264198006579 substrate binding pocket [chemical binding]; other site 264198006580 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 264198006581 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 264198006582 octamer interface [polypeptide binding]; other site 264198006583 active site 264198006584 Muconolactone delta-isomerase; Region: MIase; cl01992 264198006585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198006586 NMT1-like family; Region: NMT1_2; cl15260 264198006587 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 264198006588 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198006589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198006590 active site 264198006591 phosphorylation site [posttranslational modification] 264198006592 intermolecular recognition site; other site 264198006593 dimerization interface [polypeptide binding]; other site 264198006594 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198006595 DNA binding residues [nucleotide binding] 264198006596 dimerization interface [polypeptide binding]; other site 264198006597 Fimbrial protein; Region: Fimbrial; cl01416 264198006598 putative chaperone protein EcpD; Provisional; Region: PRK09926 264198006599 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 264198006600 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 264198006601 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 264198006602 PapC N-terminal domain; Region: PapC_N; pfam13954 264198006603 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 264198006604 PapC C-terminal domain; Region: PapC_C; pfam13953 264198006605 Fimbrial protein; Region: Fimbrial; cl01416 264198006606 Activator of aromatic catabolism; Region: XylR_N; pfam06505 264198006607 Heme NO binding; Region: HNOB; cl15268 264198006608 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 264198006609 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198006610 Walker A motif; other site 264198006611 ATP binding site [chemical binding]; other site 264198006612 Walker B motif; other site 264198006613 arginine finger; other site 264198006614 Helix-turn-helix domains; Region: HTH; cl00088 264198006615 Phenol hydroxylase subunit; Region: Phenol_hyd_sub; pfam06099 264198006616 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 264198006617 dimerization interface [polypeptide binding]; other site 264198006618 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 264198006619 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 264198006620 dimerization interface [polypeptide binding]; other site 264198006621 putative path to active site cavity [active] 264198006622 diiron center [ion binding]; other site 264198006623 Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663 264198006624 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 264198006625 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198006626 catalytic loop [active] 264198006627 iron binding site [ion binding]; other site 264198006628 Phenol 2-monooxygenase (phenol hydroxylase) is a flavoprotein monooxygenase, able to use molecular oxygen as a substrate in the microbial degredation of phenol. This protein is encoded by a single gene and uses a tightly bound FAD cofactor in the NAD(P)H...; Region: phenol_2-monooxygenase_like; cd06211 264198006629 FAD binding pocket [chemical binding]; other site 264198006630 FAD binding motif [chemical binding]; other site 264198006631 phosphate binding motif [ion binding]; other site 264198006632 beta-alpha-beta structure motif; other site 264198006633 NAD binding pocket [chemical binding]; other site 264198006634 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 264198006635 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 264198006636 dimer interface [polypeptide binding]; other site 264198006637 active site 264198006638 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 264198006639 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 264198006640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198006641 putative substrate translocation pore; other site 264198006642 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 264198006643 homotrimer interaction site [polypeptide binding]; other site 264198006644 putative active site [active] 264198006645 Helix-turn-helix domains; Region: HTH; cl00088 264198006646 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 264198006647 putative active site [active] 264198006648 catalytic site [active] 264198006649 Helix-turn-helix domains; Region: HTH; cl00088 264198006650 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 264198006651 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 264198006652 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 264198006653 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 264198006654 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 264198006655 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 264198006656 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 264198006657 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 264198006658 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 264198006659 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198006660 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264198006661 substrate binding pocket [chemical binding]; other site 264198006662 membrane-bound complex binding site; other site 264198006663 hinge residues; other site 264198006664 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 264198006665 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 264198006666 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 264198006667 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 264198006668 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 264198006669 baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596 264198006670 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 264198006671 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198006672 Walker A motif; other site 264198006673 ATP binding site [chemical binding]; other site 264198006674 Walker B motif; other site 264198006675 arginine finger; other site 264198006676 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198006677 Walker A motif; other site 264198006678 ATP binding site [chemical binding]; other site 264198006679 Walker B motif; other site 264198006680 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 264198006681 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 264198006682 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 264198006683 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 264198006684 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 264198006685 Protein of unknown function (DUF796); Region: DUF796; cl01226 264198006686 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 264198006687 Protein of unknown function (DUF877); Region: DUF877; pfam05943 264198006688 Protein of unknown function (DUF770); Region: DUF770; cl01402 264198006689 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198006690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198006691 active site 264198006692 phosphorylation site [posttranslational modification] 264198006693 intermolecular recognition site; other site 264198006694 dimerization interface [polypeptide binding]; other site 264198006695 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198006696 DNA binding residues [nucleotide binding] 264198006697 dimerization interface [polypeptide binding]; other site 264198006698 HDOD domain; Region: HDOD; pfam08668 264198006699 GAF domain; Region: GAF_2; pfam13185 264198006700 PAS domain; Region: PAS_9; pfam13426 264198006701 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198006702 putative active site [active] 264198006703 heme pocket [chemical binding]; other site 264198006704 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198006705 metal binding site [ion binding]; metal-binding site 264198006706 active site 264198006707 I-site; other site 264198006708 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264198006709 Ion channel; Region: Ion_trans_2; cl11596 264198006710 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 264198006711 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 264198006712 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198006713 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198006714 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264198006715 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 264198006716 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 264198006717 dimer interface [polypeptide binding]; other site 264198006718 active site 264198006719 heme binding site [chemical binding]; other site 264198006720 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 264198006721 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 264198006722 dinuclear metal binding motif [ion binding]; other site 264198006723 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 264198006724 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 264198006725 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 264198006726 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 264198006727 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264198006728 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 264198006729 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264198006730 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 264198006731 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 264198006732 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198006733 PAS fold; Region: PAS_3; pfam08447 264198006734 putative active site [active] 264198006735 heme pocket [chemical binding]; other site 264198006736 hypothetical protein; Provisional; Region: PRK13560 264198006737 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198006738 metal binding site [ion binding]; metal-binding site 264198006739 active site 264198006740 I-site; other site 264198006741 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 264198006742 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 264198006743 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 264198006744 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 264198006745 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264198006746 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 264198006747 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264198006748 DNA binding residues [nucleotide binding] 264198006749 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 264198006750 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 264198006751 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 264198006752 DNA-K related protein; Region: DUF3731; pfam12531 264198006753 EamA-like transporter family; Region: EamA; cl01037 264198006754 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 264198006755 EamA-like transporter family; Region: EamA; cl01037 264198006756 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 264198006757 FOG: CBS domain [General function prediction only]; Region: COG0517 264198006758 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 264198006759 TIGR03442 family protein; Region: TIGR03442 264198006760 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 264198006761 putative active site [active] 264198006762 putative dimer interface [polypeptide binding]; other site 264198006763 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 264198006764 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 264198006765 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 264198006766 peptidase domain interface [polypeptide binding]; other site 264198006767 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 264198006768 active site 264198006769 catalytic triad [active] 264198006770 calcium binding site [ion binding]; other site 264198006771 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 264198006772 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 264198006773 dimer interface [polypeptide binding]; other site 264198006774 active site 264198006775 coenzyme A binding site [chemical binding]; other site 264198006776 citrylCoA binding site [chemical binding]; other site 264198006777 oxalacetate/citrate binding site [chemical binding]; other site 264198006778 catalytic triad [active] 264198006779 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 264198006780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198006781 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198006782 classical (c) SDRs; Region: SDR_c; cd05233 264198006783 NAD(P) binding site [chemical binding]; other site 264198006784 active site 264198006785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198006786 NMT1-like family; Region: NMT1_2; cl15260 264198006787 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 264198006788 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 264198006789 FAD binding pocket [chemical binding]; other site 264198006790 FAD binding motif [chemical binding]; other site 264198006791 phosphate binding motif [ion binding]; other site 264198006792 beta-alpha-beta structure motif; other site 264198006793 NAD binding pocket [chemical binding]; other site 264198006794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198006795 putative substrate translocation pore; other site 264198006796 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 264198006797 active site 264198006798 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 264198006799 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198006800 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198006801 Family description; Region: UvrD_C_2; cl15862 264198006802 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 264198006803 Transglycosylase; Region: Transgly; cl07896 264198006804 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 264198006805 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 264198006806 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 264198006807 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 264198006808 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165 264198006809 active sites [active] 264198006810 tetramer interface [polypeptide binding]; other site 264198006811 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198006812 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264198006813 substrate binding pocket [chemical binding]; other site 264198006814 membrane-bound complex binding site; other site 264198006815 hinge residues; other site 264198006816 Cytochrome c; Region: Cytochrom_C; cl11414 264198006817 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 264198006818 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198006819 Walker A motif; other site 264198006820 ATP binding site [chemical binding]; other site 264198006821 Walker B motif; other site 264198006822 arginine finger; other site 264198006823 Helix-turn-helix domains; Region: HTH; cl00088 264198006824 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264198006825 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 264198006826 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 264198006827 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 264198006828 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264198006829 FeS/SAM binding site; other site 264198006830 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 264198006831 Cytochrome c; Region: Cytochrom_C; cl11414 264198006832 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 264198006833 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 264198006834 dimer interface [polypeptide binding]; other site 264198006835 Trp docking motif [polypeptide binding]; other site 264198006836 active site 264198006837 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198006838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198006839 active site 264198006840 phosphorylation site [posttranslational modification] 264198006841 intermolecular recognition site; other site 264198006842 dimerization interface [polypeptide binding]; other site 264198006843 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198006844 DNA binding residues [nucleotide binding] 264198006845 dimerization interface [polypeptide binding]; other site 264198006846 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264198006847 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 264198006848 Histidine kinase; Region: HisKA_3; pfam07730 264198006849 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 264198006850 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 264198006851 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264198006852 N-terminal plug; other site 264198006853 ligand-binding site [chemical binding]; other site 264198006854 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 264198006855 RNA polymerase sigma factor; Provisional; Region: PRK12533 264198006856 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264198006857 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 264198006858 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 264198006859 Aspartase; Region: Aspartase; cd01357 264198006860 active sites [active] 264198006861 tetramer interface [polypeptide binding]; other site 264198006862 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198006863 Helix-turn-helix domains; Region: HTH; cl00088 264198006864 Putative cyclase; Region: Cyclase; cl00814 264198006865 fumarylacetoacetase; Region: PLN02856 264198006866 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 264198006867 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 264198006868 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198006869 eyelet of channel; other site 264198006870 trimer interface [polypeptide binding]; other site 264198006871 Predicted acyl esterases [General function prediction only]; Region: COG2936 264198006872 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 264198006873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198006874 Surface antigen; Region: Bac_surface_Ag; cl03097 264198006875 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 264198006876 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 264198006877 ATP-grasp domain; Region: ATP-grasp_4; cl03087 264198006878 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264198006879 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 264198006880 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264198006881 Zn2+ binding site [ion binding]; other site 264198006882 Mg2+ binding site [ion binding]; other site 264198006883 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 264198006884 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 264198006885 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 264198006886 dimer interface [polypeptide binding]; other site 264198006887 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198006888 catalytic residue [active] 264198006889 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 264198006890 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198006891 DNA-binding site [nucleotide binding]; DNA binding site 264198006892 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198006893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198006894 homodimer interface [polypeptide binding]; other site 264198006895 catalytic residue [active] 264198006896 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 264198006897 Propionate catabolism activator; Region: PrpR_N; pfam06506 264198006898 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 264198006899 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 264198006900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198006901 Walker A motif; other site 264198006902 ATP binding site [chemical binding]; other site 264198006903 Walker B motif; other site 264198006904 arginine finger; other site 264198006905 Helix-turn-helix domains; Region: HTH; cl00088 264198006906 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 264198006907 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 264198006908 tetramer interface [polypeptide binding]; other site 264198006909 active site 264198006910 Mg2+/Mn2+ binding site [ion binding]; other site 264198006911 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 264198006912 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 264198006913 dimer interface [polypeptide binding]; other site 264198006914 active site 264198006915 citrylCoA binding site [chemical binding]; other site 264198006916 oxalacetate/citrate binding site [chemical binding]; other site 264198006917 coenzyme A binding site [chemical binding]; other site 264198006918 catalytic triad [active] 264198006919 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 264198006920 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 264198006921 substrate binding site [chemical binding]; other site 264198006922 ligand binding site [chemical binding]; other site 264198006923 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 264198006924 substrate binding site [chemical binding]; other site 264198006925 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 264198006926 PrpF protein; Region: PrpF; pfam04303 264198006927 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 264198006928 active site 264198006929 homodimer interface [polypeptide binding]; other site 264198006930 homotetramer interface [polypeptide binding]; other site 264198006931 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 264198006932 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264198006933 dimerization interface [polypeptide binding]; other site 264198006934 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198006935 dimer interface [polypeptide binding]; other site 264198006936 phosphorylation site [posttranslational modification] 264198006937 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198006938 ATP binding site [chemical binding]; other site 264198006939 Mg2+ binding site [ion binding]; other site 264198006940 G-X-G motif; other site 264198006941 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 264198006942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198006943 active site 264198006944 phosphorylation site [posttranslational modification] 264198006945 intermolecular recognition site; other site 264198006946 dimerization interface [polypeptide binding]; other site 264198006947 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198006948 DNA binding site [nucleotide binding] 264198006949 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 264198006950 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264198006951 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198006952 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198006953 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264198006954 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 264198006955 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198006956 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198006957 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 264198006958 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 264198006959 AMP-binding enzyme; Region: AMP-binding; cl15778 264198006960 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198006961 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198006962 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 264198006963 substrate binding site [chemical binding]; other site 264198006964 oxyanion hole (OAH) forming residues; other site 264198006965 trimer interface [polypeptide binding]; other site 264198006966 benzoate transport; Region: 2A0115; TIGR00895 264198006967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198006968 putative substrate translocation pore; other site 264198006969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198006970 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 264198006971 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 264198006972 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 264198006973 putative NAD(P) binding site [chemical binding]; other site 264198006974 catalytic Zn binding site [ion binding]; other site 264198006975 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 264198006976 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198006977 NAD binding site [chemical binding]; other site 264198006978 catalytic residues [active] 264198006979 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198006980 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198006981 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 264198006982 classical (c) SDRs; Region: SDR_c; cd05233 264198006983 NAD(P) binding site [chemical binding]; other site 264198006984 active site 264198006985 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198006986 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198006987 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198006988 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198006989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198006990 NMT1-like family; Region: NMT1_2; cl15260 264198006991 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 264198006992 DUF35 OB-fold domain; Region: DUF35; pfam01796 264198006993 thiolase; Provisional; Region: PRK06158 264198006994 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 264198006995 active site 264198006996 MoaC_like Similar to the MaoC (monoamine oxidase C) dehydratase regulatory protein but without the N-terminal PutA domain. This protein family has a hot-dog fold similar to that of (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: MaoC_like; cd03446 264198006997 homodimer interaction site [polypeptide binding]; other site 264198006998 putative active site [active] 264198006999 putative catalytic site [active] 264198007000 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198007001 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198007002 active site 264198007003 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198007004 Helix-turn-helix domains; Region: HTH; cl00088 264198007005 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198007006 dimerization interface [polypeptide binding]; other site 264198007007 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 264198007008 CoenzymeA binding site [chemical binding]; other site 264198007009 subunit interaction site [polypeptide binding]; other site 264198007010 PHB binding site; other site 264198007011 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 264198007012 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 264198007013 MOSC domain; Region: MOSC; pfam03473 264198007014 3-alpha domain; Region: 3-alpha; pfam03475 264198007015 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 264198007016 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 264198007017 catalytic triad [active] 264198007018 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 264198007019 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 264198007020 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 264198007021 active site 264198007022 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 264198007023 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198007024 NAD binding site [chemical binding]; other site 264198007025 catalytic residues [active] 264198007026 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 264198007027 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 264198007028 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 264198007029 ABC transporter; Region: ABC_tran_2; pfam12848 264198007030 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 264198007031 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 264198007032 dimer interface [polypeptide binding]; other site 264198007033 catalytic triad [active] 264198007034 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 264198007035 nucleoside/Zn binding site; other site 264198007036 dimer interface [polypeptide binding]; other site 264198007037 catalytic motif [active] 264198007038 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 264198007039 active site 264198007040 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 264198007041 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264198007042 FeS/SAM binding site; other site 264198007043 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 264198007044 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198007045 putative substrate translocation pore; other site 264198007046 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 264198007047 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 264198007048 putative active site [active] 264198007049 putative metal binding site [ion binding]; other site 264198007050 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 264198007051 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264198007052 ATP binding site [chemical binding]; other site 264198007053 putative Mg++ binding site [ion binding]; other site 264198007054 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264198007055 nucleotide binding region [chemical binding]; other site 264198007056 ATP-binding site [chemical binding]; other site 264198007057 DEAD/H associated; Region: DEAD_assoc; pfam08494 264198007058 GMP synthase; Reviewed; Region: guaA; PRK00074 264198007059 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 264198007060 AMP/PPi binding site [chemical binding]; other site 264198007061 candidate oxyanion hole; other site 264198007062 catalytic triad [active] 264198007063 potential glutamine specificity residues [chemical binding]; other site 264198007064 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 264198007065 ATP Binding subdomain [chemical binding]; other site 264198007066 Ligand Binding sites [chemical binding]; other site 264198007067 Dimerization subdomain; other site 264198007068 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 264198007069 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 264198007070 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 264198007071 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 264198007072 active site 264198007073 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 264198007074 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 264198007075 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 264198007076 putative coenzyme Q binding site [chemical binding]; other site 264198007077 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 264198007078 SmpB-tmRNA interface; other site 264198007079 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 264198007080 phosphoenolpyruvate synthase; Validated; Region: PRK06464 264198007081 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 264198007082 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 264198007083 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 264198007084 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 264198007085 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 264198007086 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 264198007087 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 264198007088 RNA/DNA hybrid binding site [nucleotide binding]; other site 264198007089 active site 264198007090 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 264198007091 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 264198007092 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 264198007093 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 264198007094 active site 264198007095 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 264198007096 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 264198007097 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 264198007098 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 264198007099 trimer interface [polypeptide binding]; other site 264198007100 active site 264198007101 UDP-GlcNAc binding site [chemical binding]; other site 264198007102 lipid binding site [chemical binding]; lipid-binding site 264198007103 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 264198007104 periplasmic chaperone; Provisional; Region: PRK10780 264198007105 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 264198007106 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 264198007107 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 264198007108 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 264198007109 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 264198007110 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 264198007111 Surface antigen; Region: Bac_surface_Ag; cl03097 264198007112 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 264198007113 zinc metallopeptidase RseP; Provisional; Region: PRK10779 264198007114 active site 264198007115 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 264198007116 protein binding site [polypeptide binding]; other site 264198007117 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 264198007118 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 264198007119 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 264198007120 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 264198007121 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 264198007122 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 264198007123 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 264198007124 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 264198007125 catalytic residue [active] 264198007126 putative FPP diphosphate binding site; other site 264198007127 putative FPP binding hydrophobic cleft; other site 264198007128 dimer interface [polypeptide binding]; other site 264198007129 putative IPP diphosphate binding site; other site 264198007130 ribosome recycling factor; Reviewed; Region: frr; PRK00083 264198007131 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 264198007132 hinge region; other site 264198007133 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 264198007134 putative nucleotide binding site [chemical binding]; other site 264198007135 uridine monophosphate binding site [chemical binding]; other site 264198007136 homohexameric interface [polypeptide binding]; other site 264198007137 elongation factor Ts; Provisional; Region: tsf; PRK09377 264198007138 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 264198007139 Elongation factor TS; Region: EF_TS; pfam00889 264198007140 Elongation factor TS; Region: EF_TS; pfam00889 264198007141 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 264198007142 rRNA interaction site [nucleotide binding]; other site 264198007143 S8 interaction site; other site 264198007144 putative laminin-1 binding site; other site 264198007145 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 264198007146 active site 264198007147 PII uridylyl-transferase; Provisional; Region: PRK03059 264198007148 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 264198007149 metal binding triad; other site 264198007150 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 264198007151 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 264198007152 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 264198007153 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 264198007154 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264198007155 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 264198007156 RNA binding surface [nucleotide binding]; other site 264198007157 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 264198007158 active site 264198007159 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 264198007160 active site 264198007161 catalytic residues [active] 264198007162 metal binding site [ion binding]; metal-binding site 264198007163 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 264198007164 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 264198007165 nucleotide binding pocket [chemical binding]; other site 264198007166 K-X-D-G motif; other site 264198007167 catalytic site [active] 264198007168 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 264198007169 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 264198007170 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 264198007171 Dimer interface [polypeptide binding]; other site 264198007172 BRCT sequence motif; other site 264198007173 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 264198007174 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 264198007175 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 264198007176 Walker A/P-loop; other site 264198007177 ATP binding site [chemical binding]; other site 264198007178 Q-loop/lid; other site 264198007179 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 264198007180 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 264198007181 ABC transporter signature motif; other site 264198007182 Walker B; other site 264198007183 D-loop; other site 264198007184 H-loop/switch region; other site 264198007185 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 264198007186 dinuclear metal binding motif [ion binding]; other site 264198007187 EamA-like transporter family; Region: EamA; cl01037 264198007188 succinyldiaminopimelate transaminase; Region: DapC_gpp; TIGR03538 264198007189 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198007190 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198007191 homodimer interface [polypeptide binding]; other site 264198007192 catalytic residue [active] 264198007193 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 264198007194 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 264198007195 trimer interface [polypeptide binding]; other site 264198007196 active site 264198007197 substrate binding site [chemical binding]; other site 264198007198 CoA binding site [chemical binding]; other site 264198007199 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 264198007200 ArsC family; Region: ArsC; pfam03960 264198007201 putative catalytic residues [active] 264198007202 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 264198007203 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 264198007204 metal binding site [ion binding]; metal-binding site 264198007205 dimer interface [polypeptide binding]; other site 264198007206 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 264198007207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198007208 S-adenosylmethionine binding site [chemical binding]; other site 264198007209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198007210 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198007211 putative substrate translocation pore; other site 264198007212 2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291 264198007213 NADP binding site [chemical binding]; other site 264198007214 dimer interface [polypeptide binding]; other site 264198007215 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 264198007216 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 264198007217 conserved cys residue [active] 264198007218 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198007219 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 264198007220 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198007221 NAD(P) binding site [chemical binding]; other site 264198007222 active site 264198007223 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198007224 Helix-turn-helix domains; Region: HTH; cl00088 264198007225 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 264198007226 putative effector binding pocket; other site 264198007227 putative dimerization interface [polypeptide binding]; other site 264198007228 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 264198007229 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198007230 NAD binding site [chemical binding]; other site 264198007231 catalytic residues [active] 264198007232 enoyl-CoA hydratase; Provisional; Region: PRK06210 264198007233 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198007234 substrate binding site [chemical binding]; other site 264198007235 oxyanion hole (OAH) forming residues; other site 264198007236 trimer interface [polypeptide binding]; other site 264198007237 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 264198007238 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 264198007239 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198007240 NAD binding site [chemical binding]; other site 264198007241 catalytic residues [active] 264198007242 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 264198007243 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198007244 substrate binding site [chemical binding]; other site 264198007245 oxyanion hole (OAH) forming residues; other site 264198007246 trimer interface [polypeptide binding]; other site 264198007247 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 264198007248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198007249 CoA-ligase; Region: Ligase_CoA; cl02894 264198007250 ATP-grasp domain; Region: ATP-grasp_4; cl03087 264198007251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198007252 NMT1-like family; Region: NMT1_2; cl15260 264198007253 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198007254 Helix-turn-helix domains; Region: HTH; cl00088 264198007255 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 264198007256 putative dimerization interface [polypeptide binding]; other site 264198007257 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 264198007258 NADP+ binding site [chemical binding]; other site 264198007259 folate binding site [chemical binding]; other site 264198007260 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 264198007261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198007262 NMT1-like family; Region: NMT1_2; cl15260 264198007263 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 264198007264 AMP-binding enzyme; Region: AMP-binding; cl15778 264198007265 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198007266 Isochorismatase family; Region: Isochorismatase; pfam00857 264198007267 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 264198007268 catalytic triad [active] 264198007269 conserved cis-peptide bond; other site 264198007270 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198007271 Helix-turn-helix domains; Region: HTH; cl00088 264198007272 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198007273 dimerization interface [polypeptide binding]; other site 264198007274 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198007275 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198007276 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 264198007277 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 264198007278 NAD(P) binding site [chemical binding]; other site 264198007279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198007280 NMT1-like family; Region: NMT1_2; cl15260 264198007281 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198007282 Helix-turn-helix domains; Region: HTH; cl00088 264198007283 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198007284 dimerization interface [polypeptide binding]; other site 264198007285 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233 264198007286 putative active site [active] 264198007287 Zn binding site [ion binding]; other site 264198007288 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 264198007289 SxDxEG motif; other site 264198007290 active site 264198007291 metal binding site [ion binding]; metal-binding site 264198007292 homopentamer interface [polypeptide binding]; other site 264198007293 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 264198007294 homodimer interface [polypeptide binding]; other site 264198007295 homotetramer interface [polypeptide binding]; other site 264198007296 active site pocket [active] 264198007297 cleavage site 264198007298 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 264198007299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198007300 dimer interface [polypeptide binding]; other site 264198007301 conserved gate region; other site 264198007302 putative PBP binding loops; other site 264198007303 ABC-ATPase subunit interface; other site 264198007304 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 264198007305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198007306 dimer interface [polypeptide binding]; other site 264198007307 conserved gate region; other site 264198007308 putative PBP binding loops; other site 264198007309 ABC-ATPase subunit interface; other site 264198007310 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 264198007311 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 264198007312 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 264198007313 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 264198007314 Walker A/P-loop; other site 264198007315 ATP binding site [chemical binding]; other site 264198007316 Q-loop/lid; other site 264198007317 ABC transporter signature motif; other site 264198007318 Walker B; other site 264198007319 D-loop; other site 264198007320 H-loop/switch region; other site 264198007321 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 264198007322 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 264198007323 Walker A/P-loop; other site 264198007324 ATP binding site [chemical binding]; other site 264198007325 Q-loop/lid; other site 264198007326 ABC transporter signature motif; other site 264198007327 Walker B; other site 264198007328 D-loop; other site 264198007329 H-loop/switch region; other site 264198007330 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 264198007331 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 264198007332 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 264198007333 catalytic nucleophile [active] 264198007334 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 264198007335 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 264198007336 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 264198007337 putative active site [active] 264198007338 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 264198007339 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 264198007340 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 264198007341 ABC transporter; Region: ABC_tran_2; pfam12848 264198007342 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 264198007343 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 264198007344 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 264198007345 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 264198007346 DNA repair protein RadA; Provisional; Region: PRK11823 264198007347 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 264198007348 Walker A motif/ATP binding site; other site 264198007349 ATP binding site [chemical binding]; other site 264198007350 Walker B motif; other site 264198007351 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 264198007352 alanine racemase; Reviewed; Region: dadX; PRK03646 264198007353 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 264198007354 active site 264198007355 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264198007356 substrate binding site [chemical binding]; other site 264198007357 catalytic residues [active] 264198007358 dimer interface [polypeptide binding]; other site 264198007359 lysophospholipid transporter LplT; Provisional; Region: PRK11195 264198007360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198007361 Domain of unknown function (DUF1853); Region: DUF1853; cl01545 264198007362 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 264198007363 Fe-S cluster binding site [ion binding]; other site 264198007364 active site 264198007365 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 264198007366 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 264198007367 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 264198007368 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 264198007369 acyl-CoA binding pocket [chemical binding]; other site 264198007370 CoA binding site [chemical binding]; other site 264198007371 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198007372 putative transporter; Provisional; Region: PRK10504 264198007373 putative substrate translocation pore; other site 264198007374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198007375 DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863 264198007376 putative hydrophobic ligand binding site [chemical binding]; other site 264198007377 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 264198007378 active site 264198007379 catalytic triad [active] 264198007380 oxyanion hole [active] 264198007381 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 264198007382 active site 264198007383 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198007384 metal binding site [ion binding]; metal-binding site 264198007385 NMT1-like family; Region: NMT1_2; cl15260 264198007386 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 264198007387 putative acyl-acceptor binding pocket; other site 264198007388 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 264198007389 CoenzymeA binding site [chemical binding]; other site 264198007390 subunit interaction site [polypeptide binding]; other site 264198007391 PHB binding site; other site 264198007392 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 264198007393 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 264198007394 catalytic residues [active] 264198007395 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 264198007396 malate synthase A; Region: malate_syn_A; TIGR01344 264198007397 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 264198007398 active site 264198007399 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 264198007400 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264198007401 Helix-turn-helix domains; Region: HTH; cl00088 264198007402 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198007403 putative effector binding pocket; other site 264198007404 dimerization interface [polypeptide binding]; other site 264198007405 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198007406 Ligand Binding Site [chemical binding]; other site 264198007407 Response regulator receiver domain; Region: Response_reg; pfam00072 264198007408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198007409 active site 264198007410 phosphorylation site [posttranslational modification] 264198007411 intermolecular recognition site; other site 264198007412 dimerization interface [polypeptide binding]; other site 264198007413 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198007414 putative CheW interface [polypeptide binding]; other site 264198007415 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264198007416 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264198007417 dimerization interface [polypeptide binding]; other site 264198007418 sensory histidine kinase AtoS; Provisional; Region: PRK11360 264198007419 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 264198007420 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 264198007421 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 264198007422 putative binding surface; other site 264198007423 active site 264198007424 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198007425 ATP binding site [chemical binding]; other site 264198007426 Mg2+ binding site [ion binding]; other site 264198007427 G-X-G motif; other site 264198007428 Protein of unknown function (DUF3562); Region: DUF3562; pfam12085 264198007429 Peptidase family M48; Region: Peptidase_M48; cl12018 264198007430 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 264198007431 tetramer interface [polypeptide binding]; other site 264198007432 active site 264198007433 Mg2+/Mn2+ binding site [ion binding]; other site 264198007434 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 264198007435 putative active site pocket [active] 264198007436 dimerization interface [polypeptide binding]; other site 264198007437 putative catalytic residue [active] 264198007438 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 264198007439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198007440 putative substrate translocation pore; other site 264198007441 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 264198007442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198007443 active site 264198007444 phosphorylation site [posttranslational modification] 264198007445 intermolecular recognition site; other site 264198007446 dimerization interface [polypeptide binding]; other site 264198007447 LytTr DNA-binding domain; Region: LytTR; cl04498 264198007448 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 264198007449 Histidine kinase; Region: His_kinase; pfam06580 264198007450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 264198007451 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 264198007452 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 264198007453 substrate binding site [chemical binding]; other site 264198007454 dimerization interface [polypeptide binding]; other site 264198007455 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 264198007456 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296 264198007457 Walker A/P-loop; other site 264198007458 ATP binding site [chemical binding]; other site 264198007459 Q-loop/lid; other site 264198007460 ABC transporter signature motif; other site 264198007461 Walker B; other site 264198007462 D-loop; other site 264198007463 H-loop/switch region; other site 264198007464 TOBE-like domain; Region: TOBE_3; pfam12857 264198007465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198007466 dimer interface [polypeptide binding]; other site 264198007467 conserved gate region; other site 264198007468 putative PBP binding loops; other site 264198007469 ABC-ATPase subunit interface; other site 264198007470 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 264198007471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198007472 dimer interface [polypeptide binding]; other site 264198007473 conserved gate region; other site 264198007474 putative PBP binding loops; other site 264198007475 ABC-ATPase subunit interface; other site 264198007476 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198007477 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 264198007478 TOBE domain; Region: TOBE_2; cl01440 264198007479 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 264198007480 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 264198007481 Walker A/P-loop; other site 264198007482 ATP binding site [chemical binding]; other site 264198007483 Q-loop/lid; other site 264198007484 ABC transporter signature motif; other site 264198007485 Walker B; other site 264198007486 D-loop; other site 264198007487 H-loop/switch region; other site 264198007488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198007489 dimer interface [polypeptide binding]; other site 264198007490 conserved gate region; other site 264198007491 putative PBP binding loops; other site 264198007492 ABC-ATPase subunit interface; other site 264198007493 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 264198007494 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 264198007495 active site 264198007496 dimer interface [polypeptide binding]; other site 264198007497 non-prolyl cis peptide bond; other site 264198007498 insertion regions; other site 264198007499 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 264198007500 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198007501 substrate binding pocket [chemical binding]; other site 264198007502 membrane-bound complex binding site; other site 264198007503 hinge residues; other site 264198007504 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198007505 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 264198007506 autotransport protein MisL; Provisional; Region: PRK15313 264198007507 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 264198007508 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 264198007509 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 264198007510 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 264198007511 Clp amino terminal domain; Region: Clp_N; pfam02861 264198007512 Clp amino terminal domain; Region: Clp_N; pfam02861 264198007513 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198007514 Walker A motif; other site 264198007515 ATP binding site [chemical binding]; other site 264198007516 Walker B motif; other site 264198007517 arginine finger; other site 264198007518 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198007519 Walker A motif; other site 264198007520 ATP binding site [chemical binding]; other site 264198007521 Walker B motif; other site 264198007522 arginine finger; other site 264198007523 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 264198007524 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 264198007525 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198007526 TM-ABC transporter signature motif; other site 264198007527 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198007528 TM-ABC transporter signature motif; other site 264198007529 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264198007530 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 264198007531 Walker A/P-loop; other site 264198007532 ATP binding site [chemical binding]; other site 264198007533 Q-loop/lid; other site 264198007534 ABC transporter signature motif; other site 264198007535 Walker B; other site 264198007536 D-loop; other site 264198007537 H-loop/switch region; other site 264198007538 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198007539 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 264198007540 Walker A/P-loop; other site 264198007541 ATP binding site [chemical binding]; other site 264198007542 Q-loop/lid; other site 264198007543 ABC transporter signature motif; other site 264198007544 Walker B; other site 264198007545 D-loop; other site 264198007546 H-loop/switch region; other site 264198007547 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198007548 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 264198007549 putative ligand binding site [chemical binding]; other site 264198007550 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198007551 Helix-turn-helix domains; Region: HTH; cl00088 264198007552 CrcB-like protein; Region: CRCB; cl09114 264198007553 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 264198007554 MoaE homodimer interface [polypeptide binding]; other site 264198007555 MoaD interaction [polypeptide binding]; other site 264198007556 active site residues [active] 264198007557 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 264198007558 MoaE interaction surface [polypeptide binding]; other site 264198007559 MoeB interaction surface [polypeptide binding]; other site 264198007560 thiocarboxylated glycine; other site 264198007561 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 264198007562 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 264198007563 dimer interface [polypeptide binding]; other site 264198007564 putative functional site; other site 264198007565 putative MPT binding site; other site 264198007566 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 264198007567 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 264198007568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198007569 catalytic residue [active] 264198007570 homoserine dehydrogenase; Provisional; Region: PRK06349 264198007571 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198007572 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 264198007573 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 264198007574 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 264198007575 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198007576 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198007577 homodimer interface [polypeptide binding]; other site 264198007578 catalytic residue [active] 264198007579 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 264198007580 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 264198007581 catalytic triad [active] 264198007582 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 264198007583 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 264198007584 putative active site [active] 264198007585 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198007586 NlpC/P60 family; Region: NLPC_P60; cl11438 264198007587 Phosphate transporter family; Region: PHO4; cl00396 264198007588 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 264198007589 replicative DNA helicase; Provisional; Region: PRK07004 264198007590 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 264198007591 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 264198007592 Walker A motif; other site 264198007593 ATP binding site [chemical binding]; other site 264198007594 Walker B motif; other site 264198007595 DNA binding loops [nucleotide binding] 264198007596 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 264198007597 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 264198007598 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 264198007599 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 264198007600 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 264198007601 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 264198007602 active site 264198007603 homotetramer interface [polypeptide binding]; other site 264198007604 homodimer interface [polypeptide binding]; other site 264198007605 LexA repressor; Validated; Region: PRK00215 264198007606 Helix-turn-helix domains; Region: HTH; cl00088 264198007607 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 264198007608 Catalytic site [active] 264198007609 Lysozyme family protein [General function prediction only]; Region: COG5526 264198007610 CHAT domain; Region: CHAT; pfam12770 264198007611 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 264198007612 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198007613 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 264198007614 structural tetrad; other site 264198007615 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 264198007616 structural tetrad; other site 264198007617 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 264198007618 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 264198007619 FMN binding site [chemical binding]; other site 264198007620 active site 264198007621 catalytic residues [active] 264198007622 substrate binding site [chemical binding]; other site 264198007623 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 264198007624 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 264198007625 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198007626 substrate binding site [chemical binding]; other site 264198007627 oxyanion hole (OAH) forming residues; other site 264198007628 trimer interface [polypeptide binding]; other site 264198007629 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 264198007630 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264198007631 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 264198007632 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264198007633 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264198007634 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198007635 dimer interface [polypeptide binding]; other site 264198007636 putative CheW interface [polypeptide binding]; other site 264198007637 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 264198007638 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 264198007639 G1 box; other site 264198007640 putative GEF interaction site [polypeptide binding]; other site 264198007641 GTP/Mg2+ binding site [chemical binding]; other site 264198007642 Switch I region; other site 264198007643 G2 box; other site 264198007644 G3 box; other site 264198007645 Switch II region; other site 264198007646 G4 box; other site 264198007647 G5 box; other site 264198007648 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 264198007649 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 264198007650 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264198007651 Helix-turn-helix domains; Region: HTH; cl00088 264198007652 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264198007653 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 264198007654 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198007655 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198007656 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 264198007657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198007658 putative substrate translocation pore; other site 264198007659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198007660 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851 264198007661 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 264198007662 RNA binding site [nucleotide binding]; other site 264198007663 active site 264198007664 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 264198007665 Ribosome-binding factor A; Region: RBFA; cl00542 264198007666 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 264198007667 translation initiation factor IF-2; Region: IF-2; TIGR00487 264198007668 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 264198007669 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 264198007670 G1 box; other site 264198007671 putative GEF interaction site [polypeptide binding]; other site 264198007672 GTP/Mg2+ binding site [chemical binding]; other site 264198007673 Switch I region; other site 264198007674 G2 box; other site 264198007675 G3 box; other site 264198007676 Switch II region; other site 264198007677 G4 box; other site 264198007678 G5 box; other site 264198007679 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 264198007680 Translation-initiation factor 2; Region: IF-2; pfam11987 264198007681 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 264198007682 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 264198007683 NusA N-terminal domain; Region: NusA_N; pfam08529 264198007684 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 264198007685 RNA binding site [nucleotide binding]; other site 264198007686 homodimer interface [polypeptide binding]; other site 264198007687 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 264198007688 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 264198007689 G-X-X-G motif; other site 264198007690 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 264198007691 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 264198007692 ribosome maturation protein RimP; Reviewed; Region: PRK00092 264198007693 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 264198007694 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 264198007695 Sm1 motif; other site 264198007696 predicted subunit interaction site [polypeptide binding]; other site 264198007697 RNA binding pocket [nucleotide binding]; other site 264198007698 Sm2 motif; other site 264198007699 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 264198007700 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264198007701 RNA binding surface [nucleotide binding]; other site 264198007702 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 264198007703 probable active site [active] 264198007704 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 264198007705 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 264198007706 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 264198007707 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198007708 ligand binding site [chemical binding]; other site 264198007709 flexible hinge region; other site 264198007710 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 264198007711 putative switch regulator; other site 264198007712 non-specific DNA interactions [nucleotide binding]; other site 264198007713 DNA binding site [nucleotide binding] 264198007714 sequence specific DNA binding site [nucleotide binding]; other site 264198007715 putative cAMP binding site [chemical binding]; other site 264198007716 FixH; Region: FixH; cl01254 264198007717 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 264198007718 4Fe-4S binding domain; Region: Fer4_5; pfam12801 264198007719 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 264198007720 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 264198007721 Cytochrome c; Region: Cytochrom_C; cl11414 264198007722 Cytochrome c; Region: Cytochrom_C; cl11414 264198007723 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cl00282 264198007724 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 264198007725 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 264198007726 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 264198007727 Low-spin heme binding site [chemical binding]; other site 264198007728 Putative water exit pathway; other site 264198007729 Binuclear center (active site) [active] 264198007730 Putative proton exit pathway; other site 264198007731 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 264198007732 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 264198007733 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 264198007734 metal-binding site [ion binding] 264198007735 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 264198007736 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264198007737 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264198007738 Predicted ATPase [General function prediction only]; Region: COG1485 264198007739 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 264198007740 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198007741 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 264198007742 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 264198007743 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 264198007744 E3 interaction surface; other site 264198007745 lipoyl attachment site [posttranslational modification]; other site 264198007746 e3 binding domain; Region: E3_binding; pfam02817 264198007747 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 264198007748 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 264198007749 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 264198007750 TPP-binding site [chemical binding]; other site 264198007751 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 264198007752 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 264198007753 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 264198007754 putative active site [active] 264198007755 catalytic site [active] 264198007756 putative metal binding site [ion binding]; other site 264198007757 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 264198007758 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 264198007759 Walker A/P-loop; other site 264198007760 ATP binding site [chemical binding]; other site 264198007761 Q-loop/lid; other site 264198007762 ABC transporter signature motif; other site 264198007763 Walker B; other site 264198007764 D-loop; other site 264198007765 H-loop/switch region; other site 264198007766 TOBE domain; Region: TOBE_2; cl01440 264198007767 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 264198007768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198007769 dimer interface [polypeptide binding]; other site 264198007770 conserved gate region; other site 264198007771 putative PBP binding loops; other site 264198007772 ABC-ATPase subunit interface; other site 264198007773 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 264198007774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198007775 dimer interface [polypeptide binding]; other site 264198007776 conserved gate region; other site 264198007777 putative PBP binding loops; other site 264198007778 ABC-ATPase subunit interface; other site 264198007779 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 264198007780 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198007781 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 264198007782 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264198007783 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 264198007784 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198007785 active site 264198007786 phosphorylation site [posttranslational modification] 264198007787 intermolecular recognition site; other site 264198007788 dimerization interface [polypeptide binding]; other site 264198007789 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198007790 Walker A motif; other site 264198007791 ATP binding site [chemical binding]; other site 264198007792 Walker B motif; other site 264198007793 arginine finger; other site 264198007794 Helix-turn-helix domains; Region: HTH; cl00088 264198007795 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 264198007796 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198007797 dimer interface [polypeptide binding]; other site 264198007798 phosphorylation site [posttranslational modification] 264198007799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198007800 ATP binding site [chemical binding]; other site 264198007801 Mg2+ binding site [ion binding]; other site 264198007802 G-X-G motif; other site 264198007803 glutamine synthetase; Provisional; Region: glnA; PRK09469 264198007804 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 264198007805 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 264198007806 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 264198007807 active site residue [active] 264198007808 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 264198007809 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 264198007810 putative MPT binding site; other site 264198007811 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 264198007812 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 264198007813 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 264198007814 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 264198007815 NodB motif; other site 264198007816 active site 264198007817 catalytic site [active] 264198007818 metal binding site [ion binding]; metal-binding site 264198007819 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 264198007820 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 264198007821 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264198007822 ATP binding site [chemical binding]; other site 264198007823 putative Mg++ binding site [ion binding]; other site 264198007824 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264198007825 nucleotide binding region [chemical binding]; other site 264198007826 ATP-binding site [chemical binding]; other site 264198007827 Helicase associated domain (HA2); Region: HA2; cl04503 264198007828 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 264198007829 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 264198007830 N-acetylglutamate synthase; Validated; Region: PRK05279 264198007831 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 264198007832 putative feedback inhibition sensing region; other site 264198007833 putative nucleotide binding site [chemical binding]; other site 264198007834 putative substrate binding site [chemical binding]; other site 264198007835 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 264198007836 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 264198007837 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 264198007838 tetramer (dimer of dimers) interface [polypeptide binding]; other site 264198007839 active site 264198007840 dimer interface [polypeptide binding]; other site 264198007841 transaldolase-like protein; Provisional; Region: PTZ00411 264198007842 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 264198007843 active site 264198007844 dimer interface [polypeptide binding]; other site 264198007845 catalytic residue [active] 264198007846 NAD-dependent deacetylase; Provisional; Region: PRK00481 264198007847 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 264198007848 NAD+ binding site [chemical binding]; other site 264198007849 substrate binding site [chemical binding]; other site 264198007850 Zn binding site [ion binding]; other site 264198007851 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 264198007852 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 264198007853 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 264198007854 ribonuclease R; Region: RNase_R; TIGR02063 264198007855 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 264198007856 RNB domain; Region: RNB; pfam00773 264198007857 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 264198007858 RNA binding site [nucleotide binding]; other site 264198007859 Predicted transcriptional regulator [Transcription]; Region: COG1959 264198007860 Helix-turn-helix domains; Region: HTH; cl00088 264198007861 Helix-turn-helix domains; Region: HTH; cl00088 264198007862 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 264198007863 NADH(P)-binding; Region: NAD_binding_10; pfam13460 264198007864 NAD binding site [chemical binding]; other site 264198007865 substrate binding site [chemical binding]; other site 264198007866 putative active site [active] 264198007867 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264198007868 active site 264198007869 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 264198007870 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 264198007871 GDP-binding site [chemical binding]; other site 264198007872 ACT binding site; other site 264198007873 IMP binding site; other site 264198007874 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 264198007875 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 264198007876 dimer interface [polypeptide binding]; other site 264198007877 motif 1; other site 264198007878 active site 264198007879 motif 2; other site 264198007880 motif 3; other site 264198007881 HflC protein; Region: hflC; TIGR01932 264198007882 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 264198007883 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 264198007884 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 264198007885 HflK protein; Region: hflK; TIGR01933 264198007886 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 264198007887 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 264198007888 HflX GTPase family; Region: HflX; cd01878 264198007889 G1 box; other site 264198007890 GTP/Mg2+ binding site [chemical binding]; other site 264198007891 Switch I region; other site 264198007892 G2 box; other site 264198007893 G3 box; other site 264198007894 Switch II region; other site 264198007895 G4 box; other site 264198007896 G5 box; other site 264198007897 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 264198007898 Sm1 motif; other site 264198007899 intra - hexamer interaction site; other site 264198007900 inter - hexamer interaction site [polypeptide binding]; other site 264198007901 nucleotide binding pocket [chemical binding]; other site 264198007902 Sm2 motif; other site 264198007903 GTP-binding protein Der; Reviewed; Region: PRK00093 264198007904 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 264198007905 G1 box; other site 264198007906 GTP/Mg2+ binding site [chemical binding]; other site 264198007907 Switch I region; other site 264198007908 G2 box; other site 264198007909 Switch II region; other site 264198007910 G3 box; other site 264198007911 G4 box; other site 264198007912 G5 box; other site 264198007913 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 264198007914 G1 box; other site 264198007915 GTP/Mg2+ binding site [chemical binding]; other site 264198007916 Switch I region; other site 264198007917 G2 box; other site 264198007918 G3 box; other site 264198007919 Switch II region; other site 264198007920 G4 box; other site 264198007921 G5 box; other site 264198007922 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 264198007923 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 264198007924 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 264198007925 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 264198007926 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 264198007927 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 264198007928 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 264198007929 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 264198007930 dimer interface [polypeptide binding]; other site 264198007931 motif 1; other site 264198007932 active site 264198007933 motif 2; other site 264198007934 motif 3; other site 264198007935 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 264198007936 anticodon binding site; other site 264198007937 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 264198007938 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 264198007939 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 264198007940 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 264198007941 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 264198007942 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264198007943 binding surface 264198007944 TPR motif; other site 264198007945 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264198007946 binding surface 264198007947 TPR motif; other site 264198007948 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 264198007949 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264198007950 FeS/SAM binding site; other site 264198007951 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 264198007952 active site 264198007953 multimer interface [polypeptide binding]; other site 264198007954 YccA-like proteins; Region: YccA_like; cd10433 264198007955 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 264198007956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 264198007957 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 264198007958 putative catalytic site [active] 264198007959 putative metal binding site [ion binding]; other site 264198007960 putative phosphate binding site [ion binding]; other site 264198007961 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 264198007962 active site 264198007963 catalytic site [active] 264198007964 substrate binding site [chemical binding]; other site 264198007965 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 264198007966 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 264198007967 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 264198007968 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264198007969 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 264198007970 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264198007971 DNA binding residues [nucleotide binding] 264198007972 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264198007973 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 264198007974 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 264198007975 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 264198007976 Survival protein SurE; Region: SurE; cl00448 264198007977 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 264198007978 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 264198007979 NAD(P) binding site [chemical binding]; other site 264198007980 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198007981 trimer interface [polypeptide binding]; other site 264198007982 eyelet of channel; other site 264198007983 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 264198007984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198007985 active site 264198007986 phosphorylation site [posttranslational modification] 264198007987 intermolecular recognition site; other site 264198007988 dimerization interface [polypeptide binding]; other site 264198007989 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198007990 DNA binding site [nucleotide binding] 264198007991 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 264198007992 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264198007993 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198007994 dimer interface [polypeptide binding]; other site 264198007995 phosphorylation site [posttranslational modification] 264198007996 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198007997 ATP binding site [chemical binding]; other site 264198007998 Mg2+ binding site [ion binding]; other site 264198007999 G-X-G motif; other site 264198008000 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 264198008001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 264198008002 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 264198008003 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 264198008004 Walker A/P-loop; other site 264198008005 ATP binding site [chemical binding]; other site 264198008006 Q-loop/lid; other site 264198008007 ABC transporter signature motif; other site 264198008008 Walker B; other site 264198008009 D-loop; other site 264198008010 H-loop/switch region; other site 264198008011 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 264198008012 NMT1-like family; Region: NMT1_2; cl15260 264198008013 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198008014 NMT1-like family; Region: NMT1_2; cl15260 264198008015 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 264198008016 active site 264198008017 catalytic residues [active] 264198008018 metal binding site [ion binding]; metal-binding site 264198008019 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198008020 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198008021 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198008022 Helix-turn-helix domains; Region: HTH; cl00088 264198008023 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 264198008024 putative dimerization interface [polypeptide binding]; other site 264198008025 recombination protein RecR; Reviewed; Region: recR; PRK00076 264198008026 RecR protein; Region: RecR; pfam02132 264198008027 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 264198008028 putative active site [active] 264198008029 putative metal-binding site [ion binding]; other site 264198008030 tetramer interface [polypeptide binding]; other site 264198008031 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 264198008032 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 264198008033 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198008034 Walker A motif; other site 264198008035 ATP binding site [chemical binding]; other site 264198008036 Walker B motif; other site 264198008037 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198008038 arginine finger; other site 264198008039 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 264198008040 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 264198008041 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 264198008042 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 264198008043 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 264198008044 active site 264198008045 dimer interface [polypeptide binding]; other site 264198008046 effector binding site; other site 264198008047 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 264198008048 Cys-rich peptide, TIGR04165 family; Region: methano_modCys 264198008049 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 264198008050 Family description; Region: UvrD_C_2; cl15862 264198008051 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 264198008052 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 264198008053 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 264198008054 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 264198008055 catalytic residues [active] 264198008056 transcription termination factor Rho; Provisional; Region: rho; PRK09376 264198008057 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 264198008058 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 264198008059 RNA binding site [nucleotide binding]; other site 264198008060 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 264198008061 multimer interface [polypeptide binding]; other site 264198008062 Walker A motif; other site 264198008063 ATP binding site [chemical binding]; other site 264198008064 Walker B motif; other site 264198008065 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 264198008066 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 264198008067 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 264198008068 multidrug efflux protein; Reviewed; Region: PRK01766 264198008069 MatE; Region: MatE; cl10513 264198008070 MatE; Region: MatE; cl10513 264198008071 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 264198008072 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 264198008073 active site 264198008074 HIGH motif; other site 264198008075 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 264198008076 active site 264198008077 KMSKS motif; other site 264198008078 hypothetical protein; Provisional; Region: PRK10279 264198008079 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 264198008080 nucleophile elbow; other site 264198008081 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 264198008082 NlpC/P60 family; Region: NLPC_P60; cl11438 264198008083 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 264198008084 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 264198008085 Walker A/P-loop; other site 264198008086 ATP binding site [chemical binding]; other site 264198008087 Q-loop/lid; other site 264198008088 ABC transporter signature motif; other site 264198008089 Walker B; other site 264198008090 D-loop; other site 264198008091 H-loop/switch region; other site 264198008092 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 264198008093 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 264198008094 Walker A/P-loop; other site 264198008095 ATP binding site [chemical binding]; other site 264198008096 Q-loop/lid; other site 264198008097 ABC transporter signature motif; other site 264198008098 Walker B; other site 264198008099 D-loop; other site 264198008100 H-loop/switch region; other site 264198008101 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 264198008102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198008103 dimer interface [polypeptide binding]; other site 264198008104 conserved gate region; other site 264198008105 putative PBP binding loops; other site 264198008106 ABC-ATPase subunit interface; other site 264198008107 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 264198008108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198008109 dimer interface [polypeptide binding]; other site 264198008110 conserved gate region; other site 264198008111 putative PBP binding loops; other site 264198008112 ABC-ATPase subunit interface; other site 264198008113 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 264198008114 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 264198008115 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 264198008116 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 264198008117 NAD binding site [chemical binding]; other site 264198008118 homotetramer interface [polypeptide binding]; other site 264198008119 homodimer interface [polypeptide binding]; other site 264198008120 substrate binding site [chemical binding]; other site 264198008121 active site 264198008122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198008123 putative substrate translocation pore; other site 264198008124 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198008125 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198008126 trimer interface [polypeptide binding]; other site 264198008127 eyelet of channel; other site 264198008128 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 264198008129 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 264198008130 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198008131 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198008132 Phasin protein; Region: Phasin_2; cl11491 264198008133 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 264198008134 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 264198008135 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 264198008136 putative active site [active] 264198008137 putative catalytic site [active] 264198008138 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 264198008139 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 264198008140 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198008141 active site 264198008142 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 264198008143 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198008144 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198008145 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198008146 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198008147 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198008148 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198008149 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 264198008150 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 264198008151 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 264198008152 catalytic residues [active] 264198008153 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 264198008154 AMP-binding enzyme; Region: AMP-binding; cl15778 264198008155 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198008156 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 264198008157 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 264198008158 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 264198008159 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 264198008160 NADP binding site [chemical binding]; other site 264198008161 dimer interface [polypeptide binding]; other site 264198008162 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198008163 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198008164 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 264198008165 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cl02586 264198008166 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198008167 metal binding site [ion binding]; metal-binding site 264198008168 active site 264198008169 I-site; other site 264198008170 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 264198008171 rRNA binding site [nucleotide binding]; other site 264198008172 predicted 30S ribosome binding site; other site 264198008173 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264198008174 catalytic core [active] 264198008175 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 264198008176 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 264198008177 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 264198008178 polyphosphate kinase; Provisional; Region: PRK05443 264198008179 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 264198008180 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 264198008181 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 264198008182 putative domain interface [polypeptide binding]; other site 264198008183 putative active site [active] 264198008184 catalytic site [active] 264198008185 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 264198008186 putative domain interface [polypeptide binding]; other site 264198008187 putative active site [active] 264198008188 catalytic site [active] 264198008189 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 264198008190 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 264198008191 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198008192 dimer interface [polypeptide binding]; other site 264198008193 phosphorylation site [posttranslational modification] 264198008194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198008195 ATP binding site [chemical binding]; other site 264198008196 Mg2+ binding site [ion binding]; other site 264198008197 G-X-G motif; other site 264198008198 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 264198008199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198008200 active site 264198008201 phosphorylation site [posttranslational modification] 264198008202 intermolecular recognition site; other site 264198008203 dimerization interface [polypeptide binding]; other site 264198008204 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198008205 DNA binding site [nucleotide binding] 264198008206 transcriptional regulator PhoU; Provisional; Region: PRK11115 264198008207 PhoU domain; Region: PhoU; pfam01895 264198008208 PhoU domain; Region: PhoU; pfam01895 264198008209 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 264198008210 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 264198008211 Walker A/P-loop; other site 264198008212 ATP binding site [chemical binding]; other site 264198008213 Q-loop/lid; other site 264198008214 ABC transporter signature motif; other site 264198008215 Walker B; other site 264198008216 D-loop; other site 264198008217 H-loop/switch region; other site 264198008218 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 264198008219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198008220 dimer interface [polypeptide binding]; other site 264198008221 conserved gate region; other site 264198008222 putative PBP binding loops; other site 264198008223 ABC-ATPase subunit interface; other site 264198008224 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 264198008225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198008226 dimer interface [polypeptide binding]; other site 264198008227 conserved gate region; other site 264198008228 ABC-ATPase subunit interface; other site 264198008229 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198008230 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 264198008231 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 264198008232 active site 264198008233 substrate binding site [chemical binding]; other site 264198008234 metal binding site [ion binding]; metal-binding site 264198008235 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 264198008236 dihydropteroate synthase; Region: DHPS; TIGR01496 264198008237 substrate binding pocket [chemical binding]; other site 264198008238 dimer interface [polypeptide binding]; other site 264198008239 inhibitor binding site; inhibition site 264198008240 FtsH Extracellular; Region: FtsH_ext; pfam06480 264198008241 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 264198008242 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198008243 Walker A motif; other site 264198008244 ATP binding site [chemical binding]; other site 264198008245 Walker B motif; other site 264198008246 arginine finger; other site 264198008247 Peptidase family M41; Region: Peptidase_M41; pfam01434 264198008248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 264198008249 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 264198008250 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 264198008251 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 264198008252 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 264198008253 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 264198008254 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 264198008255 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 264198008256 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264198008257 ATP-grasp domain; Region: ATP-grasp_4; cl03087 264198008258 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 264198008259 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264198008260 ATP-grasp domain; Region: ATP-grasp_4; cl03087 264198008261 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 264198008262 IMP binding site; other site 264198008263 dimer interface [polypeptide binding]; other site 264198008264 interdomain contacts; other site 264198008265 partial ornithine binding site; other site 264198008266 LysE type translocator; Region: LysE; cl00565 264198008267 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 264198008268 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 264198008269 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 264198008270 catalytic site [active] 264198008271 subunit interface [polypeptide binding]; other site 264198008272 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 264198008273 homotrimer interaction site [polypeptide binding]; other site 264198008274 putative active site [active] 264198008275 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 264198008276 active site 264198008277 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 264198008278 AMP-binding enzyme; Region: AMP-binding; cl15778 264198008279 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198008280 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198008281 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198008282 active site 264198008283 enoyl-CoA hydratase; Provisional; Region: PRK06688 264198008284 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198008285 substrate binding site [chemical binding]; other site 264198008286 oxyanion hole (OAH) forming residues; other site 264198008287 trimer interface [polypeptide binding]; other site 264198008288 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198008289 classical (c) SDRs; Region: SDR_c; cd05233 264198008290 NAD(P) binding site [chemical binding]; other site 264198008291 active site 264198008292 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 264198008293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198008294 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 264198008295 active site 264198008296 FMN binding site [chemical binding]; other site 264198008297 substrate binding site [chemical binding]; other site 264198008298 homotetramer interface [polypeptide binding]; other site 264198008299 catalytic residue [active] 264198008300 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 264198008301 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 264198008302 AMP-binding enzyme; Region: AMP-binding; cl15778 264198008303 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198008304 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 264198008305 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 264198008306 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264198008307 catalytic residue [active] 264198008308 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264198008309 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264198008310 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 264198008311 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 264198008312 RNA/DNA hybrid binding site [nucleotide binding]; other site 264198008313 active site 264198008314 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 264198008315 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 264198008316 active site 264198008317 catalytic site [active] 264198008318 substrate binding site [chemical binding]; other site 264198008319 integrase; Provisional; Region: PRK09692 264198008320 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 264198008321 active site 264198008322 Int/Topo IB signature motif; other site 264198008323 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 264198008324 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 264198008325 Protein of unknown function (DUF1484); Region: DUF1484; pfam07363 264198008326 DNA primase domain-containing protein; Region: PHA02415 264198008327 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 264198008328 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264198008329 MULE transposase domain; Region: MULE; pfam10551 264198008330 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 264198008331 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 264198008332 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 264198008333 PAS fold; Region: PAS_4; pfam08448 264198008334 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198008335 metal binding site [ion binding]; metal-binding site 264198008336 active site 264198008337 I-site; other site 264198008338 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 264198008339 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198008340 Predicted small integral membrane protein (DUF2160); Region: DUF2160; cl02294 264198008341 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 264198008342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198008343 dimer interface [polypeptide binding]; other site 264198008344 conserved gate region; other site 264198008345 putative PBP binding loops; other site 264198008346 ABC-ATPase subunit interface; other site 264198008347 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 264198008348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198008349 putative PBP binding loops; other site 264198008350 dimer interface [polypeptide binding]; other site 264198008351 ABC-ATPase subunit interface; other site 264198008352 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 264198008353 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 264198008354 Walker A/P-loop; other site 264198008355 ATP binding site [chemical binding]; other site 264198008356 Q-loop/lid; other site 264198008357 ABC transporter signature motif; other site 264198008358 Walker B; other site 264198008359 D-loop; other site 264198008360 H-loop/switch region; other site 264198008361 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 264198008362 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 264198008363 Walker A/P-loop; other site 264198008364 ATP binding site [chemical binding]; other site 264198008365 Q-loop/lid; other site 264198008366 ABC transporter signature motif; other site 264198008367 Walker B; other site 264198008368 D-loop; other site 264198008369 H-loop/switch region; other site 264198008370 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 264198008371 Helix-turn-helix domains; Region: HTH; cl00088 264198008372 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 264198008373 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 264198008374 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 264198008375 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 264198008376 putative active site [active] 264198008377 putative substrate binding site [chemical binding]; other site 264198008378 putative cosubstrate binding site; other site 264198008379 catalytic site [active] 264198008380 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 264198008381 nudix motif; other site 264198008382 glycerol kinase; Provisional; Region: glpK; PRK00047 264198008383 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 264198008384 N- and C-terminal domain interface [polypeptide binding]; other site 264198008385 active site 264198008386 MgATP binding site [chemical binding]; other site 264198008387 catalytic site [active] 264198008388 metal binding site [ion binding]; metal-binding site 264198008389 glycerol binding site [chemical binding]; other site 264198008390 homotetramer interface [polypeptide binding]; other site 264198008391 homodimer interface [polypeptide binding]; other site 264198008392 FBP binding site [chemical binding]; other site 264198008393 protein IIAGlc interface [polypeptide binding]; other site 264198008394 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 264198008395 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198008396 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 264198008397 Copper resistance protein D; Region: CopD; cl00563 264198008398 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 264198008399 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 264198008400 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264198008401 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198008402 metal binding site [ion binding]; metal-binding site 264198008403 active site 264198008404 I-site; other site 264198008405 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264198008406 ligand binding site [chemical binding]; other site 264198008407 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 264198008408 homodimer interface [polypeptide binding]; other site 264198008409 substrate-cofactor binding pocket; other site 264198008410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198008411 catalytic residue [active] 264198008412 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 264198008413 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 264198008414 putative trimer interface [polypeptide binding]; other site 264198008415 putative CoA binding site [chemical binding]; other site 264198008416 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 264198008417 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 264198008418 Na binding site [ion binding]; other site 264198008419 acetyl-CoA synthetase; Provisional; Region: PRK00174 264198008420 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 264198008421 AMP-binding enzyme; Region: AMP-binding; cl15778 264198008422 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198008423 EamA-like transporter family; Region: EamA; cl01037 264198008424 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 264198008425 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 264198008426 Fumarase C-terminus; Region: Fumerase_C; cl00795 264198008427 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 264198008428 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 264198008429 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198008430 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 264198008431 Walker A motif; other site 264198008432 ATP binding site [chemical binding]; other site 264198008433 Walker B motif; other site 264198008434 arginine finger; other site 264198008435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198008436 Walker A motif; other site 264198008437 ATP binding site [chemical binding]; other site 264198008438 Walker B motif; other site 264198008439 arginine finger; other site 264198008440 Gram-negative bacterial tonB protein; Region: TonB; cl10048 264198008441 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 264198008442 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 264198008443 N-acetylglutamate synthase; Validated; Region: PRK05279 264198008444 Hemin uptake protein hemP; Region: hemP; cl10043 264198008445 Domain of unknown function (DUF336); Region: DUF336; cl01249 264198008446 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 264198008447 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 264198008448 Helix-turn-helix domains; Region: HTH; cl00088 264198008449 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 264198008450 putative dimerization interface [polypeptide binding]; other site 264198008451 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 264198008452 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 264198008453 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 264198008454 GIY-YIG motif/motif A; other site 264198008455 active site 264198008456 catalytic site [active] 264198008457 putative DNA binding site [nucleotide binding]; other site 264198008458 metal binding site [ion binding]; metal-binding site 264198008459 UvrB/uvrC motif; Region: UVR; pfam02151 264198008460 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 264198008461 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; cl01823 264198008462 elongation factor P; Validated; Region: PRK00529 264198008463 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 264198008464 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 264198008465 RNA binding site [nucleotide binding]; other site 264198008466 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 264198008467 RNA binding site [nucleotide binding]; other site 264198008468 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 264198008469 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 264198008470 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 264198008471 active site 264198008472 hydrophilic channel; other site 264198008473 dimerization interface [polypeptide binding]; other site 264198008474 catalytic residues [active] 264198008475 active site lid [active] 264198008476 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 264198008477 Recombination protein O N terminal; Region: RecO_N; cl15812 264198008478 Recombination protein O C terminal; Region: RecO_C; pfam02565 264198008479 GTPase Era; Reviewed; Region: era; PRK00089 264198008480 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 264198008481 G1 box; other site 264198008482 GTP/Mg2+ binding site [chemical binding]; other site 264198008483 Switch I region; other site 264198008484 G2 box; other site 264198008485 Switch II region; other site 264198008486 G3 box; other site 264198008487 G4 box; other site 264198008488 G5 box; other site 264198008489 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 264198008490 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 264198008491 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 264198008492 dimerization interface [polypeptide binding]; other site 264198008493 active site 264198008494 metal binding site [ion binding]; metal-binding site 264198008495 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 264198008496 signal peptidase I; Provisional; Region: PRK10861 264198008497 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 264198008498 Catalytic site [active] 264198008499 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 264198008500 GTP-binding protein LepA; Provisional; Region: PRK05433 264198008501 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 264198008502 G1 box; other site 264198008503 putative GEF interaction site [polypeptide binding]; other site 264198008504 GTP/Mg2+ binding site [chemical binding]; other site 264198008505 Switch I region; other site 264198008506 G2 box; other site 264198008507 G3 box; other site 264198008508 Switch II region; other site 264198008509 G4 box; other site 264198008510 G5 box; other site 264198008511 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 264198008512 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 264198008513 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 264198008514 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 264198008515 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 264198008516 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 264198008517 protein binding site [polypeptide binding]; other site 264198008518 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 264198008519 protein binding site [polypeptide binding]; other site 264198008520 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 264198008521 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 264198008522 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 264198008523 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 264198008524 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264198008525 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264198008526 DNA binding residues [nucleotide binding] 264198008527 BT1 family; Region: BT1; pfam03092 264198008528 Protein of unknown function (DUF1036); Region: DUF1036; cl02296 264198008529 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 264198008530 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 264198008531 dimer interface [polypeptide binding]; other site 264198008532 active site 264198008533 Phosphopantetheine attachment site; Region: PP-binding; cl09936 264198008534 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 264198008535 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 264198008536 NAD(P) binding site [chemical binding]; other site 264198008537 homotetramer interface [polypeptide binding]; other site 264198008538 homodimer interface [polypeptide binding]; other site 264198008539 active site 264198008540 Acyl transferase domain; Region: Acyl_transf_1; cl08282 264198008541 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 264198008542 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 264198008543 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 264198008544 dimer interface [polypeptide binding]; other site 264198008545 active site 264198008546 CoA binding pocket [chemical binding]; other site 264198008547 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 264198008548 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 264198008549 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 264198008550 Maf-like protein; Region: Maf; pfam02545 264198008551 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 264198008552 active site 264198008553 dimer interface [polypeptide binding]; other site 264198008554 Predicted methyltransferases [General function prediction only]; Region: COG0313 264198008555 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 264198008556 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 264198008557 tandem repeat interface [polypeptide binding]; other site 264198008558 oligomer interface [polypeptide binding]; other site 264198008559 active site residues [active] 264198008560 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 264198008561 iron-sulfur cluster [ion binding]; other site 264198008562 [2Fe-2S] cluster binding site [ion binding]; other site 264198008563 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 264198008564 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264198008565 motif II; other site 264198008566 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 264198008567 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264198008568 RNA binding surface [nucleotide binding]; other site 264198008569 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 264198008570 active site 264198008571 ribonuclease E; Reviewed; Region: rne; PRK10811 264198008572 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 264198008573 homodimer interface [polypeptide binding]; other site 264198008574 oligonucleotide binding site [chemical binding]; other site 264198008575 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 264198008576 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264198008577 FeS/SAM binding site; other site 264198008578 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 264198008579 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 264198008580 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 264198008581 GTP binding site; other site 264198008582 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 264198008583 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 264198008584 dimer interface [polypeptide binding]; other site 264198008585 putative functional site; other site 264198008586 putative MPT binding site; other site 264198008587 hypothetical protein; Provisional; Region: PRK11281 264198008588 RmuC family; Region: RmuC; pfam02646 264198008589 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 264198008590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198008591 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 264198008592 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 264198008593 transmembrane helices; other site 264198008594 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 264198008595 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 264198008596 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 264198008597 active site 264198008598 Ferredoxin [Energy production and conversion]; Region: COG1146 264198008599 4Fe-4S binding domain; Region: Fer4; cl02805 264198008600 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 264198008601 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 264198008602 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198008603 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 264198008604 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198008605 active site 264198008606 phosphorylation site [posttranslational modification] 264198008607 intermolecular recognition site; other site 264198008608 dimerization interface [polypeptide binding]; other site 264198008609 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198008610 DNA binding site [nucleotide binding] 264198008611 sensor protein KdpD; Provisional; Region: PRK10490 264198008612 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 264198008613 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 264198008614 Ligand Binding Site [chemical binding]; other site 264198008615 GAF domain; Region: GAF; cl15785 264198008616 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198008617 phosphorylation site [posttranslational modification] 264198008618 dimer interface [polypeptide binding]; other site 264198008619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198008620 ATP binding site [chemical binding]; other site 264198008621 Mg2+ binding site [ion binding]; other site 264198008622 G-X-G motif; other site 264198008623 K+-transporting ATPase, c chain; Region: KdpC; cl00944 264198008624 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 264198008625 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264198008626 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264198008627 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 264198008628 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 264198008629 nodulation ABC transporter NodI; Provisional; Region: PRK13537 264198008630 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 264198008631 Walker A/P-loop; other site 264198008632 ATP binding site [chemical binding]; other site 264198008633 Q-loop/lid; other site 264198008634 ABC transporter signature motif; other site 264198008635 Walker B; other site 264198008636 D-loop; other site 264198008637 H-loop/switch region; other site 264198008638 ABC-2 type transporter; Region: ABC2_membrane; cl11417 264198008639 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 264198008640 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 264198008641 homodimer interface [polypeptide binding]; other site 264198008642 substrate-cofactor binding pocket; other site 264198008643 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198008644 catalytic residue [active] 264198008645 amidophosphoribosyltransferase; Provisional; Region: PRK09246 264198008646 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 264198008647 active site 264198008648 tetramer interface [polypeptide binding]; other site 264198008649 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264198008650 active site 264198008651 Colicin V production protein; Region: Colicin_V; cl00567 264198008652 Sporulation related domain; Region: SPOR; cl10051 264198008653 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 264198008654 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264198008655 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 264198008656 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 264198008657 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 264198008658 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 264198008659 substrate binding site [chemical binding]; other site 264198008660 active site 264198008661 catalytic residues [active] 264198008662 heterodimer interface [polypeptide binding]; other site 264198008663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 264198008664 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 264198008665 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 264198008666 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198008667 catalytic residue [active] 264198008668 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 264198008669 active site 264198008670 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 264198008671 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 264198008672 dimerization interface 3.5A [polypeptide binding]; other site 264198008673 active site 264198008674 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 264198008675 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 264198008676 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 264198008677 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 264198008678 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 264198008679 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 264198008680 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198008681 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 264198008682 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 264198008683 tartrate dehydrogenase; Provisional; Region: PRK08194 264198008684 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 264198008685 substrate binding site [chemical binding]; other site 264198008686 Entericidin EcnA/B family; Region: Entericidin; cl02322 264198008687 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 264198008688 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 264198008689 substrate binding site [chemical binding]; other site 264198008690 ligand binding site [chemical binding]; other site 264198008691 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 264198008692 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 264198008693 Walker A/P-loop; other site 264198008694 ATP binding site [chemical binding]; other site 264198008695 Q-loop/lid; other site 264198008696 ABC transporter signature motif; other site 264198008697 Walker B; other site 264198008698 D-loop; other site 264198008699 H-loop/switch region; other site 264198008700 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 264198008701 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 264198008702 Walker A/P-loop; other site 264198008703 ATP binding site [chemical binding]; other site 264198008704 Q-loop/lid; other site 264198008705 ABC transporter signature motif; other site 264198008706 Walker B; other site 264198008707 D-loop; other site 264198008708 H-loop/switch region; other site 264198008709 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 264198008710 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 264198008711 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198008712 TM-ABC transporter signature motif; other site 264198008713 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198008714 TM-ABC transporter signature motif; other site 264198008715 leucine ABC transporter subunit substrate-binding protein LivK; Provisional; Region: PRK15404 264198008716 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 264198008717 dimerization interface [polypeptide binding]; other site 264198008718 ligand binding site [chemical binding]; other site 264198008719 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 264198008720 dimer interface [polypeptide binding]; other site 264198008721 Citrate synthase; Region: Citrate_synt; pfam00285 264198008722 active site 264198008723 citrylCoA binding site [chemical binding]; other site 264198008724 NADH binding [chemical binding]; other site 264198008725 cationic pore residues; other site 264198008726 oxalacetate/citrate binding site [chemical binding]; other site 264198008727 coenzyme A binding site [chemical binding]; other site 264198008728 catalytic triad [active] 264198008729 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 264198008730 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 264198008731 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 264198008732 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 264198008733 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198008734 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 264198008735 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 264198008736 SdhC subunit interface [polypeptide binding]; other site 264198008737 proximal heme binding site [chemical binding]; other site 264198008738 cardiolipin binding site; other site 264198008739 Iron-sulfur protein interface; other site 264198008740 proximal quinone binding site [chemical binding]; other site 264198008741 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 264198008742 Iron-sulfur protein interface; other site 264198008743 proximal quinone binding site [chemical binding]; other site 264198008744 SdhD (CybS) interface [polypeptide binding]; other site 264198008745 proximal heme binding site [chemical binding]; other site 264198008746 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 264198008747 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198008748 DNA-binding site [nucleotide binding]; DNA binding site 264198008749 UTRA domain; Region: UTRA; cl01230 264198008750 malate dehydrogenase; Provisional; Region: PRK05442 264198008751 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 264198008752 NAD(P) binding site [chemical binding]; other site 264198008753 dimer interface [polypeptide binding]; other site 264198008754 malate binding site [chemical binding]; other site 264198008755 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 264198008756 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 264198008757 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 264198008758 dimer interface [polypeptide binding]; other site 264198008759 active site 264198008760 citrylCoA binding site [chemical binding]; other site 264198008761 oxalacetate/citrate binding site [chemical binding]; other site 264198008762 coenzyme A binding site [chemical binding]; other site 264198008763 catalytic triad [active] 264198008764 aconitate hydratase; Provisional; Region: acnA; PRK12881 264198008765 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 264198008766 substrate binding site [chemical binding]; other site 264198008767 ligand binding site [chemical binding]; other site 264198008768 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 264198008769 substrate binding site [chemical binding]; other site 264198008770 Protein of unknown function (DUF2863); Region: DUF2863; pfam11062 264198008771 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 264198008772 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 264198008773 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 264198008774 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 264198008775 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 264198008776 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 264198008777 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264198008778 catalytic residue [active] 264198008779 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 264198008780 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264198008781 dimerization interface [polypeptide binding]; other site 264198008782 putative DNA binding site [nucleotide binding]; other site 264198008783 putative Zn2+ binding site [ion binding]; other site 264198008784 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 264198008785 GST_N family, Class Phi subfamily; composed of plant-specific class Phi GSTs and related fungal and bacterial proteins. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide...; Region: GST_N_Phi; cd03053 264198008786 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264198008787 C-terminal domain interface [polypeptide binding]; other site 264198008788 GSH binding site (G-site) [chemical binding]; other site 264198008789 dimer interface [polypeptide binding]; other site 264198008790 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 264198008791 N-terminal domain interface [polypeptide binding]; other site 264198008792 dimer interface [polypeptide binding]; other site 264198008793 substrate binding pocket (H-site) [chemical binding]; other site 264198008794 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 264198008795 putative active site [active] 264198008796 heat shock protein 90; Provisional; Region: PRK05218 264198008797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198008798 ATP binding site [chemical binding]; other site 264198008799 Mg2+ binding site [ion binding]; other site 264198008800 G-X-G motif; other site 264198008801 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 264198008802 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198008803 DNA-binding site [nucleotide binding]; DNA binding site 264198008804 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198008805 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198008806 homodimer interface [polypeptide binding]; other site 264198008807 catalytic residue [active] 264198008808 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 264198008809 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 264198008810 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 264198008811 LysE type translocator; Region: LysE; cl00565 264198008812 EamA-like transporter family; Region: EamA; cl01037 264198008813 EamA-like transporter family; Region: EamA; cl01037 264198008814 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 264198008815 homotrimer interaction site [polypeptide binding]; other site 264198008816 putative active site [active] 264198008817 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 264198008818 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198008819 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198008820 homodimer interface [polypeptide binding]; other site 264198008821 catalytic residue [active] 264198008822 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264198008823 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 264198008824 putative C-terminal domain interface [polypeptide binding]; other site 264198008825 putative GSH binding site (G-site) [chemical binding]; other site 264198008826 putative dimer interface [polypeptide binding]; other site 264198008827 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 264198008828 putative N-terminal domain interface [polypeptide binding]; other site 264198008829 putative dimer interface [polypeptide binding]; other site 264198008830 putative substrate binding pocket (H-site) [chemical binding]; other site 264198008831 LysE type translocator; Region: LysE; cl00565 264198008832 L-lactate permease; Region: Lactate_perm; cl00701 264198008833 Chromate transporter; Region: Chromate_transp; pfam02417 264198008834 Chromate transporter; Region: Chromate_transp; pfam02417 264198008835 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 264198008836 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 264198008837 CAP-like domain; other site 264198008838 active site 264198008839 primary dimer interface [polypeptide binding]; other site 264198008840 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 264198008841 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264198008842 catalytic residue [active] 264198008843 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 264198008844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198008845 ATP binding site [chemical binding]; other site 264198008846 Mg2+ binding site [ion binding]; other site 264198008847 G-X-G motif; other site 264198008848 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 264198008849 anchoring element; other site 264198008850 dimer interface [polypeptide binding]; other site 264198008851 ATP binding site [chemical binding]; other site 264198008852 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 264198008853 active site 264198008854 metal binding site [ion binding]; metal-binding site 264198008855 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 264198008856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198008857 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198008858 putative substrate translocation pore; other site 264198008859 ABC transporter ATPase component; Reviewed; Region: PRK11147 264198008860 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 264198008861 Walker A/P-loop; other site 264198008862 ATP binding site [chemical binding]; other site 264198008863 Q-loop/lid; other site 264198008864 ABC transporter signature motif; other site 264198008865 Walker B; other site 264198008866 D-loop; other site 264198008867 H-loop/switch region; other site 264198008868 ABC transporter; Region: ABC_tran_2; pfam12848 264198008869 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 264198008870 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198008871 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264198008872 substrate binding pocket [chemical binding]; other site 264198008873 membrane-bound complex binding site; other site 264198008874 hinge residues; other site 264198008875 benzoate transporter; Region: benE; TIGR00843 264198008876 Benzoate membrane transport protein; Region: BenE; pfam03594 264198008877 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 264198008878 integrase; Provisional; Region: PRK09692 264198008879 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 264198008880 active site 264198008881 Int/Topo IB signature motif; other site 264198008882 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 264198008883 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 264198008884 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 264198008885 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 264198008886 substrate interaction site [chemical binding]; other site 264198008887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 264198008888 Protein of unknown function (DUF3268); Region: DUF3268; pfam11672 264198008889 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 264198008890 recF protein; Region: recf; TIGR00611 264198008891 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198008892 Walker A/P-loop; other site 264198008893 ATP binding site [chemical binding]; other site 264198008894 Ribosome modulation factor; Region: RMF; cl01207 264198008895 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 264198008896 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 264198008897 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 264198008898 Predicted transcriptional regulator [Transcription]; Region: COG2932 264198008899 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 264198008900 Catalytic site [active] 264198008901 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 264198008902 Protein of unknown function (DUF1376); Region: DUF1376; cl01531 264198008903 Endodeoxyribonuclease RusA; Region: RusA; cl01885 264198008904 ParB-like nuclease domain; Region: ParBc; cl02129 264198008905 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 264198008906 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 264198008907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 264198008908 Terminase-like family; Region: Terminase_6; pfam03237 264198008909 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 264198008910 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567; cl12082 264198008911 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 264198008912 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 264198008913 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; cl15403 264198008914 Encapsulating protein for peroxidase; Region: Linocin_M18; cl12047 264198008915 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 264198008916 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 264198008917 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 264198008918 Protein of unknown function (DUF3277); Region: DUF3277; pfam11681 264198008919 Baseplate J-like protein; Region: Baseplate_J; cl01294 264198008920 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 264198008921 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 264198008922 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264198008923 catalytic residue [active] 264198008924 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 264198008925 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 264198008926 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 264198008927 Protein phosphatase 2C; Region: PP2C; pfam00481 264198008928 active site 264198008929 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198008930 Helix-turn-helix domains; Region: HTH; cl00088 264198008931 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463 264198008932 putative substrate binding pocket [chemical binding]; other site 264198008933 putative dimerization interface [polypeptide binding]; other site 264198008934 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 264198008935 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 264198008936 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 264198008937 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 264198008938 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 264198008939 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 264198008940 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264198008941 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 264198008942 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 264198008943 XdhC Rossmann domain; Region: XdhC_C; pfam13478 264198008944 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 264198008945 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 264198008946 active site 264198008947 purine riboside binding site [chemical binding]; other site 264198008948 guanine deaminase; Provisional; Region: PRK09228 264198008949 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 264198008950 active site 264198008951 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 264198008952 Fatty acid desaturase; Region: FA_desaturase; pfam00487 264198008953 putative di-iron ligands [ion binding]; other site 264198008954 Predicted membrane protein [Function unknown]; Region: COG2119 264198008955 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 264198008956 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 264198008957 Dehydratase family; Region: ILVD_EDD; cl00340 264198008958 Predicted membrane protein [Function unknown]; Region: COG3748 264198008959 Protein of unknown function (DUF989); Region: DUF989; pfam06181 264198008960 Cytochrome c; Region: Cytochrom_C; cl11414 264198008961 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 264198008962 active site 264198008963 homotetramer interface [polypeptide binding]; other site 264198008964 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264198008965 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198008966 DNA-binding site [nucleotide binding]; DNA binding site 264198008967 FCD domain; Region: FCD; cl11656 264198008968 xanthine permease; Region: pbuX; TIGR03173 264198008969 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 264198008970 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 264198008971 active site 264198008972 catalytic site [active] 264198008973 tetramer interface [polypeptide binding]; other site 264198008974 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 264198008975 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198008976 trimer interface [polypeptide binding]; other site 264198008977 eyelet of channel; other site 264198008978 malic enzyme; Reviewed; Region: PRK12862 264198008979 Malic enzyme, N-terminal domain; Region: malic; pfam00390 264198008980 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 264198008981 putative NAD(P) binding site [chemical binding]; other site 264198008982 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 264198008983 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 264198008984 aminopeptidase N; Provisional; Region: pepN; PRK14015 264198008985 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 264198008986 active site 264198008987 Zn binding site [ion binding]; other site 264198008988 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 264198008989 AMP binding site [chemical binding]; other site 264198008990 metal binding site [ion binding]; metal-binding site 264198008991 active site 264198008992 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264198008993 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198008994 DNA-binding site [nucleotide binding]; DNA binding site 264198008995 FCD domain; Region: FCD; cl11656 264198008996 benzoate transport; Region: 2A0115; TIGR00895 264198008997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198008998 putative substrate translocation pore; other site 264198008999 Protein of unknown function (DUF1445); Region: DUF1445; cl01790 264198009000 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 264198009001 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 264198009002 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 264198009003 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 264198009004 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264198009005 ATP-grasp domain; Region: ATP-grasp_4; cl03087 264198009006 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 264198009007 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264198009008 carboxyltransferase (CT) interaction site; other site 264198009009 biotinylation site [posttranslational modification]; other site 264198009010 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198009011 PAS domain; Region: PAS_9; pfam13426 264198009012 putative active site [active] 264198009013 heme pocket [chemical binding]; other site 264198009014 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264198009015 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198009016 dimer interface [polypeptide binding]; other site 264198009017 putative CheW interface [polypeptide binding]; other site 264198009018 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 264198009019 putative hydrophobic ligand binding site [chemical binding]; other site 264198009020 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264198009021 dimerization interface [polypeptide binding]; other site 264198009022 putative DNA binding site [nucleotide binding]; other site 264198009023 putative Zn2+ binding site [ion binding]; other site 264198009024 Protein of unknown function (DUF342); Region: DUF342; pfam03961 264198009025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 264198009026 Protein of unknown function (DUF1415); Region: DUF1415; cl01301 264198009027 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198009028 HI0933-like protein; Region: HI0933_like; pfam03486 264198009029 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198009030 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 264198009031 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 264198009032 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198009033 DNA-binding site [nucleotide binding]; DNA binding site 264198009034 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198009035 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198009036 homodimer interface [polypeptide binding]; other site 264198009037 catalytic residue [active] 264198009038 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198009039 PAS domain; Region: PAS_9; pfam13426 264198009040 putative active site [active] 264198009041 heme pocket [chemical binding]; other site 264198009042 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198009043 metal binding site [ion binding]; metal-binding site 264198009044 active site 264198009045 I-site; other site 264198009046 Cupin domain; Region: Cupin_2; cl09118 264198009047 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 264198009048 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 264198009049 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 264198009050 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 264198009051 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 264198009052 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 264198009053 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 264198009054 synthetase active site [active] 264198009055 NTP binding site [chemical binding]; other site 264198009056 metal binding site [ion binding]; metal-binding site 264198009057 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 264198009058 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 264198009059 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 264198009060 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 264198009061 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 264198009062 catalytic site [active] 264198009063 G-X2-G-X-G-K; other site 264198009064 hypothetical protein; Provisional; Region: PRK11820 264198009065 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 264198009066 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 264198009067 Protein kinase domain; Region: Pkinase; pfam00069 264198009068 Catalytic domain of Protein Kinases; Region: PKc; cd00180 264198009069 active site 264198009070 ATP binding site [chemical binding]; other site 264198009071 substrate binding site [chemical binding]; other site 264198009072 activation loop (A-loop); other site 264198009073 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 264198009074 Protein phosphatase 2C; Region: PP2C; pfam00481 264198009075 active site 264198009076 ribonuclease PH; Reviewed; Region: rph; PRK00173 264198009077 Ribonuclease PH; Region: RNase_PH_bact; cd11362 264198009078 hexamer interface [polypeptide binding]; other site 264198009079 active site 264198009080 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 264198009081 active site 264198009082 dimerization interface [polypeptide binding]; other site 264198009083 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 264198009084 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264198009085 FeS/SAM binding site; other site 264198009086 HemN C-terminal domain; Region: HemN_C; pfam06969 264198009087 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198009088 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 264198009089 Bacterial sugar transferase; Region: Bac_transf; cl00939 264198009090 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 264198009091 ATP-grasp domain; Region: ATP-grasp_4; cl03087 264198009092 Protein of unknown function, DUF; Region: DUF411; cl01142 264198009093 Copper resistance protein D; Region: CopD; cl00563 264198009094 Bacterial Ig-like domain; Region: Big_5; cl01012 264198009095 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 264198009096 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 264198009097 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 264198009098 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 264198009099 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 264198009100 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 264198009101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198009102 active site 264198009103 phosphorylation site [posttranslational modification] 264198009104 intermolecular recognition site; other site 264198009105 dimerization interface [polypeptide binding]; other site 264198009106 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198009107 DNA binding site [nucleotide binding] 264198009108 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 264198009109 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264198009110 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198009111 dimer interface [polypeptide binding]; other site 264198009112 phosphorylation site [posttranslational modification] 264198009113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198009114 ATP binding site [chemical binding]; other site 264198009115 Mg2+ binding site [ion binding]; other site 264198009116 G-X-G motif; other site 264198009117 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 264198009118 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 264198009119 Walker A/P-loop; other site 264198009120 ATP binding site [chemical binding]; other site 264198009121 Q-loop/lid; other site 264198009122 ABC transporter signature motif; other site 264198009123 Walker B; other site 264198009124 D-loop; other site 264198009125 H-loop/switch region; other site 264198009126 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 264198009127 FOG: CBS domain [General function prediction only]; Region: COG0517 264198009128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198009129 dimer interface [polypeptide binding]; other site 264198009130 conserved gate region; other site 264198009131 ABC-ATPase subunit interface; other site 264198009132 NMT1-like family; Region: NMT1_2; cl15260 264198009133 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 264198009134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198009135 dimer interface [polypeptide binding]; other site 264198009136 conserved gate region; other site 264198009137 putative PBP binding loops; other site 264198009138 ABC-ATPase subunit interface; other site 264198009139 Pirin-related protein [General function prediction only]; Region: COG1741 264198009140 Cupin domain; Region: Cupin_2; cl09118 264198009141 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 264198009142 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 264198009143 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 264198009144 Walker A/P-loop; other site 264198009145 ATP binding site [chemical binding]; other site 264198009146 Q-loop/lid; other site 264198009147 ABC transporter signature motif; other site 264198009148 Walker B; other site 264198009149 D-loop; other site 264198009150 H-loop/switch region; other site 264198009151 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 264198009152 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 264198009153 TM-ABC transporter signature motif; other site 264198009154 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 264198009155 TM-ABC transporter signature motif; other site 264198009156 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 264198009157 putative ligand binding site [chemical binding]; other site 264198009158 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 264198009159 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 264198009160 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 264198009161 NADP binding site [chemical binding]; other site 264198009162 dimer interface [polypeptide binding]; other site 264198009163 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 264198009164 active site 264198009165 dimer interfaces [polypeptide binding]; other site 264198009166 catalytic residues [active] 264198009167 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 264198009168 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 264198009169 putative NAD(P) binding site [chemical binding]; other site 264198009170 putative active site [active] 264198009171 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 264198009172 EamA-like transporter family; Region: EamA; cl01037 264198009173 EamA-like transporter family; Region: EamA; cl01037 264198009174 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198009175 NMT1-like family; Region: NMT1_2; cl15260 264198009176 Transcriptional regulators [Transcription]; Region: MarR; COG1846 264198009177 Helix-turn-helix domains; Region: HTH; cl00088 264198009178 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264198009179 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 264198009180 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 264198009181 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264198009182 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264198009183 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198009184 Helix-turn-helix domains; Region: HTH; cl00088 264198009185 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015 264198009186 Isochorismatase family; Region: Isochorismatase; pfam00857 264198009187 catalytic triad [active] 264198009188 substrate binding site [chemical binding]; other site 264198009189 domain interfaces; other site 264198009190 conserved cis-peptide bond; other site 264198009191 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 264198009192 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264198009193 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 264198009194 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 264198009195 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198009196 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 264198009197 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 264198009198 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 264198009199 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 264198009200 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 264198009201 Cytochrome c; Region: Cytochrom_C; cl11414 264198009202 benzoate transport; Region: 2A0115; TIGR00895 264198009203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198009204 putative substrate translocation pore; other site 264198009205 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264198009206 active site 264198009207 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 264198009208 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 264198009209 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198009210 Walker A motif; other site 264198009211 ATP binding site [chemical binding]; other site 264198009212 Transcriptional regulator; Region: Transcrip_reg; cl00361 264198009213 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 264198009214 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 264198009215 ATP-grasp domain; Region: ATP-grasp_4; cl03087 264198009216 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 264198009217 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 264198009218 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 264198009219 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 264198009220 active site 264198009221 (T/H)XGH motif; other site 264198009222 Oligomerisation domain; Region: Oligomerisation; cl00519 264198009223 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 264198009224 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 264198009225 Maf-like protein; Region: Maf; pfam02545 264198009226 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 264198009227 active site 264198009228 dimer interface [polypeptide binding]; other site 264198009229 ribonuclease G; Provisional; Region: PRK11712 264198009230 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 264198009231 homodimer interface [polypeptide binding]; other site 264198009232 oligonucleotide binding site [chemical binding]; other site 264198009233 alanine racemase; Reviewed; Region: dadX; PRK03646 264198009234 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 264198009235 active site 264198009236 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264198009237 substrate binding site [chemical binding]; other site 264198009238 catalytic residues [active] 264198009239 dimer interface [polypeptide binding]; other site 264198009240 Protein of unknown function (DUF1376); Region: DUF1376; cl01531 264198009241 PA26 p53-induced protein (sestrin); Region: PA26; pfam04636 264198009242 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 264198009243 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 264198009244 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 264198009245 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 264198009246 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 264198009247 Walker A/P-loop; other site 264198009248 ATP binding site [chemical binding]; other site 264198009249 Q-loop/lid; other site 264198009250 ABC transporter signature motif; other site 264198009251 Walker B; other site 264198009252 D-loop; other site 264198009253 H-loop/switch region; other site 264198009254 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 264198009255 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 264198009256 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 264198009257 generic binding surface II; other site 264198009258 generic binding surface I; other site 264198009259 rhodanese superfamily protein; Provisional; Region: PRK05320 264198009260 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 264198009261 active site residue [active] 264198009262 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 264198009263 putative active site [active] 264198009264 putative CoA binding site [chemical binding]; other site 264198009265 nudix motif; other site 264198009266 metal binding site [ion binding]; metal-binding site 264198009267 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 264198009268 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 264198009269 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 264198009270 RimM N-terminal domain; Region: RimM; pfam01782 264198009271 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 264198009272 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 264198009273 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 264198009274 TM2 domain; Region: TM2; cl00984 264198009275 transcriptional activator TtdR; Provisional; Region: PRK09801 264198009276 Helix-turn-helix domains; Region: HTH; cl00088 264198009277 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198009278 putative effector binding pocket; other site 264198009279 dimerization interface [polypeptide binding]; other site 264198009280 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 264198009281 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264198009282 FeS/SAM binding site; other site 264198009283 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 264198009284 Helix-turn-helix domains; Region: HTH; cl00088 264198009285 AsnC family; Region: AsnC_trans_reg; pfam01037 264198009286 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 264198009287 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198009288 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 264198009289 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 264198009290 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198009291 active site 264198009292 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 264198009293 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 264198009294 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 264198009295 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 264198009296 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 264198009297 Ligand binding site [chemical binding]; other site 264198009298 Electron transfer flavoprotein domain; Region: ETF; pfam01012 264198009299 NMT1-like family; Region: NMT1_2; cl15260 264198009300 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 264198009301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198009302 ABC-ATPase subunit interface; other site 264198009303 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 264198009304 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 264198009305 Walker A/P-loop; other site 264198009306 ATP binding site [chemical binding]; other site 264198009307 Q-loop/lid; other site 264198009308 ABC transporter signature motif; other site 264198009309 Walker B; other site 264198009310 D-loop; other site 264198009311 H-loop/switch region; other site 264198009312 NIL domain; Region: NIL; cl09633 264198009313 enoyl-CoA hydratase; Validated; Region: PRK08139 264198009314 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198009315 substrate binding site [chemical binding]; other site 264198009316 oxyanion hole (OAH) forming residues; other site 264198009317 trimer interface [polypeptide binding]; other site 264198009318 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 264198009319 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 264198009320 Transglycosylase SLT domain; Region: SLT_2; pfam13406 264198009321 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 264198009322 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264198009323 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 264198009324 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 264198009325 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 264198009326 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 264198009327 Ligand binding site; other site 264198009328 metal-binding site 264198009329 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 264198009330 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 264198009331 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 264198009332 putative active site [active] 264198009333 cysteine synthase B; Region: cysM; TIGR01138 264198009334 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 264198009335 dimer interface [polypeptide binding]; other site 264198009336 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198009337 catalytic residue [active] 264198009338 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 264198009339 Protein of unknown function, DUF655; Region: DUF655; pfam04919 264198009340 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 264198009341 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 264198009342 NADP binding site [chemical binding]; other site 264198009343 homopentamer interface [polypeptide binding]; other site 264198009344 substrate binding site [chemical binding]; other site 264198009345 active site 264198009346 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 264198009347 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 264198009348 putative ribose interaction site [chemical binding]; other site 264198009349 putative ADP binding site [chemical binding]; other site 264198009350 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 264198009351 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198009352 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 264198009353 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198009354 tetratricopeptide repeat protein; Provisional; Region: PRK11788 264198009355 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264198009356 binding surface 264198009357 TPR motif; other site 264198009358 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 264198009359 IHF dimer interface [polypeptide binding]; other site 264198009360 IHF - DNA interface [nucleotide binding]; other site 264198009361 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 264198009362 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 264198009363 RNA binding site [nucleotide binding]; other site 264198009364 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 264198009365 RNA binding site [nucleotide binding]; other site 264198009366 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 264198009367 RNA binding site [nucleotide binding]; other site 264198009368 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec4; cd05689 264198009369 RNA binding site [nucleotide binding]; other site 264198009370 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690 264198009371 RNA binding site [nucleotide binding]; other site 264198009372 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691 264198009373 RNA binding site [nucleotide binding]; other site 264198009374 cytidylate kinase; Provisional; Region: cmk; PRK00023 264198009375 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 264198009376 CMP-binding site; other site 264198009377 The sites determining sugar specificity; other site 264198009378 Predicted membrane protein (DUF2061); Region: DUF2061; cl01257 264198009379 3-phosphoshikimate 1-carboxyvinyltransferase; Region: PLN02338 264198009380 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 264198009381 hinge; other site 264198009382 active site 264198009383 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 264198009384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198009385 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 264198009386 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198009387 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198009388 homodimer interface [polypeptide binding]; other site 264198009389 catalytic residue [active] 264198009390 Chorismate mutase type II; Region: CM_2; cl00693 264198009391 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 264198009392 Prephenate dehydratase; Region: PDT; pfam00800 264198009393 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 264198009394 putative L-Phe binding site [chemical binding]; other site 264198009395 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 264198009396 homodimer interface [polypeptide binding]; other site 264198009397 substrate-cofactor binding pocket; other site 264198009398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198009399 catalytic residue [active] 264198009400 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 264198009401 DNA gyrase subunit A; Validated; Region: PRK05560 264198009402 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 264198009403 CAP-like domain; other site 264198009404 active site 264198009405 primary dimer interface [polypeptide binding]; other site 264198009406 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264198009407 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264198009408 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264198009409 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264198009410 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264198009411 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264198009412 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 264198009413 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264198009414 ligand binding site [chemical binding]; other site 264198009415 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 264198009416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198009417 S-adenosylmethionine binding site [chemical binding]; other site 264198009418 phosphoglycolate phosphatase; Provisional; Region: PRK13222 264198009419 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264198009420 motif II; other site 264198009421 Domain of unknown function (DUF1854); Region: DUF1854; pfam08909 264198009422 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 264198009423 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 264198009424 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 264198009425 Walker A/P-loop; other site 264198009426 ATP binding site [chemical binding]; other site 264198009427 Q-loop/lid; other site 264198009428 ABC transporter signature motif; other site 264198009429 Walker B; other site 264198009430 D-loop; other site 264198009431 H-loop/switch region; other site 264198009432 cyanophycin synthetase; Provisional; Region: PRK14016 264198009433 ATP-grasp domain; Region: ATP-grasp_4; cl03087 264198009434 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264198009435 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264198009436 cyanophycin synthetase; Provisional; Region: PRK14016 264198009437 ATP-grasp domain; Region: ATP-grasp_4; cl03087 264198009438 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264198009439 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264198009440 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 264198009441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198009442 dimer interface [polypeptide binding]; other site 264198009443 conserved gate region; other site 264198009444 putative PBP binding loops; other site 264198009445 ABC-ATPase subunit interface; other site 264198009446 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264198009447 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198009448 substrate binding pocket [chemical binding]; other site 264198009449 membrane-bound complex binding site; other site 264198009450 hinge residues; other site 264198009451 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 264198009452 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198009453 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 264198009454 Helix-turn-helix domains; Region: HTH; cl00088 264198009455 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 264198009456 putative dimerization interface [polypeptide binding]; other site 264198009457 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 264198009458 Domain of unknown function DUF21; Region: DUF21; pfam01595 264198009459 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 264198009460 Transporter associated domain; Region: CorC_HlyC; cl08393 264198009461 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 264198009462 active site 264198009463 Protein of unknown function (DUF1653); Region: DUF1653; cl01949 264198009464 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 264198009465 seryl-tRNA synthetase; Provisional; Region: PRK05431 264198009466 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 264198009467 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 264198009468 dimer interface [polypeptide binding]; other site 264198009469 active site 264198009470 motif 1; other site 264198009471 motif 2; other site 264198009472 motif 3; other site 264198009473 recombination factor protein RarA; Reviewed; Region: PRK13342 264198009474 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198009475 Walker A motif; other site 264198009476 ATP binding site [chemical binding]; other site 264198009477 Walker B motif; other site 264198009478 arginine finger; other site 264198009479 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 264198009480 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 264198009481 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 264198009482 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 264198009483 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198009484 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 264198009485 thioredoxin reductase; Provisional; Region: PRK10262 264198009486 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198009487 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 264198009488 Smr domain; Region: Smr; cl02619 264198009489 Predicted membrane protein [Function unknown]; Region: COG2860 264198009490 UPF0126 domain; Region: UPF0126; pfam03458 264198009491 UPF0126 domain; Region: UPF0126; pfam03458 264198009492 Nitrogen regulatory protein P-II; Region: P-II; cl00412 264198009493 Nitrogen regulatory protein P-II; Region: P-II; smart00938 264198009494 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 264198009495 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 264198009496 conserved cys residue [active] 264198009497 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198009498 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198009499 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323 264198009500 gating phenylalanine in ion channel; other site 264198009501 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 264198009502 NAD synthetase; Reviewed; Region: nadE; PRK02628 264198009503 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 264198009504 multimer interface [polypeptide binding]; other site 264198009505 active site 264198009506 catalytic triad [active] 264198009507 protein interface 1 [polypeptide binding]; other site 264198009508 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 264198009509 homodimer interface [polypeptide binding]; other site 264198009510 NAD binding pocket [chemical binding]; other site 264198009511 ATP binding pocket [chemical binding]; other site 264198009512 Mg binding site [ion binding]; other site 264198009513 active-site loop [active] 264198009514 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 264198009515 Protein of unknown function, DUF482; Region: DUF482; pfam04339 264198009516 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 264198009517 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 264198009518 dimer interface [polypeptide binding]; other site 264198009519 substrate binding site [chemical binding]; other site 264198009520 metal binding sites [ion binding]; metal-binding site 264198009521 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198009522 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 264198009523 NAD(P) binding site [chemical binding]; other site 264198009524 catalytic residues [active] 264198009525 catalytic residues [active] 264198009526 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198009527 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198009528 NAD(P) binding site [chemical binding]; other site 264198009529 active site 264198009530 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 264198009531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198009532 putative substrate translocation pore; other site 264198009533 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 264198009534 putative binding surface; other site 264198009535 active site 264198009536 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 264198009537 putative binding surface; other site 264198009538 active site 264198009539 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 264198009540 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 264198009541 putative binding surface; other site 264198009542 active site 264198009543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198009544 ATP binding site [chemical binding]; other site 264198009545 Mg2+ binding site [ion binding]; other site 264198009546 G-X-G motif; other site 264198009547 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 264198009548 Response regulator receiver domain; Region: Response_reg; pfam00072 264198009549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198009550 active site 264198009551 phosphorylation site [posttranslational modification] 264198009552 intermolecular recognition site; other site 264198009553 dimerization interface [polypeptide binding]; other site 264198009554 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 264198009555 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264198009556 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198009557 dimer interface [polypeptide binding]; other site 264198009558 putative CheW interface [polypeptide binding]; other site 264198009559 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 264198009560 Response regulator receiver domain; Region: Response_reg; pfam00072 264198009561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198009562 active site 264198009563 phosphorylation site [posttranslational modification] 264198009564 intermolecular recognition site; other site 264198009565 dimerization interface [polypeptide binding]; other site 264198009566 Response regulator receiver domain; Region: Response_reg; pfam00072 264198009567 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198009568 active site 264198009569 phosphorylation site [posttranslational modification] 264198009570 intermolecular recognition site; other site 264198009571 dimerization interface [polypeptide binding]; other site 264198009572 Rubredoxin [Energy production and conversion]; Region: COG1773 264198009573 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 264198009574 iron binding site [ion binding]; other site 264198009575 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 264198009576 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264198009577 inhibitor-cofactor binding pocket; inhibition site 264198009578 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198009579 catalytic residue [active] 264198009580 LemA family; Region: LemA; cl00742 264198009581 Repair protein; Region: Repair_PSII; cl01535 264198009582 Repair protein; Region: Repair_PSII; cl01535 264198009583 Phospholipid methyltransferase; Region: PEMT; cl00763 264198009584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198009585 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198009586 putative substrate translocation pore; other site 264198009587 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 264198009588 Helix-turn-helix domains; Region: HTH; cl00088 264198009589 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 264198009590 dimerization interface [polypeptide binding]; other site 264198009591 substrate binding pocket [chemical binding]; other site 264198009592 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 264198009593 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198009594 Walker A motif; other site 264198009595 ATP binding site [chemical binding]; other site 264198009596 Walker B motif; other site 264198009597 arginine finger; other site 264198009598 Helix-turn-helix domains; Region: HTH; cl00088 264198009599 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 264198009600 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198009601 S-adenosylmethionine binding site [chemical binding]; other site 264198009602 GtrA-like protein; Region: GtrA; cl00971 264198009603 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 264198009604 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 264198009605 Ligand binding site; other site 264198009606 Putative Catalytic site; other site 264198009607 DXD motif; other site 264198009608 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 264198009609 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 264198009610 Flp/Fap pilin component; Region: Flp_Fap; cl01585 264198009611 Flp/Fap pilin component; Region: Flp_Fap; cl01585 264198009612 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 264198009613 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198009614 Walker A motif; other site 264198009615 ATP binding site [chemical binding]; other site 264198009616 Walker B motif; other site 264198009617 arginine finger; other site 264198009618 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 264198009619 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 264198009620 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 264198009621 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 264198009622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198009623 intermolecular recognition site; other site 264198009624 active site 264198009625 dimerization interface [polypeptide binding]; other site 264198009626 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 264198009627 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 264198009628 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 264198009629 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 264198009630 ATP binding site [chemical binding]; other site 264198009631 Walker A motif; other site 264198009632 hexamer interface [polypeptide binding]; other site 264198009633 Walker B motif; other site 264198009634 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 264198009635 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 264198009636 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 264198009637 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 264198009638 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264198009639 putative active site [active] 264198009640 putative metal binding site [ion binding]; other site 264198009641 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 264198009642 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 264198009643 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 264198009644 TadE-like protein; Region: TadE; cl10688 264198009645 TadE-like protein; Region: TadE; cl10688 264198009646 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 264198009647 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 264198009648 ring oligomerisation interface [polypeptide binding]; other site 264198009649 ATP/Mg binding site [chemical binding]; other site 264198009650 stacking interactions; other site 264198009651 hinge regions; other site 264198009652 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 264198009653 oligomerisation interface [polypeptide binding]; other site 264198009654 mobile loop; other site 264198009655 roof hairpin; other site 264198009656 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 264198009657 substrate binding pocket [chemical binding]; other site 264198009658 membrane-bound complex binding site; other site 264198009659 hinge residues; other site 264198009660 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 264198009661 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264198009662 catalytic residue [active] 264198009663 Helix-turn-helix domains; Region: HTH; cl00088 264198009664 dimerization interface [polypeptide binding]; other site 264198009665 putative DNA binding site [nucleotide binding]; other site 264198009666 putative Zn2+ binding site [ion binding]; other site 264198009667 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 264198009668 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 264198009669 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264198009670 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264198009671 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 264198009672 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 264198009673 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 264198009674 OpgC protein; Region: OpgC_C; cl00792 264198009675 Acyltransferase family; Region: Acyl_transf_3; pfam01757 264198009676 Cytochrome c; Region: Cytochrom_C; cl11414 264198009677 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 264198009678 MASE1; Region: MASE1; pfam05231 264198009679 putative diguanylate cyclase; Provisional; Region: PRK09776 264198009680 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198009681 putative active site [active] 264198009682 heme pocket [chemical binding]; other site 264198009683 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 264198009684 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 264198009685 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198009686 metal binding site [ion binding]; metal-binding site 264198009687 active site 264198009688 I-site; other site 264198009689 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264198009690 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 264198009691 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 264198009692 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 264198009693 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198009694 dimer interface [polypeptide binding]; other site 264198009695 phosphorylation site [posttranslational modification] 264198009696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198009697 ATP binding site [chemical binding]; other site 264198009698 Mg2+ binding site [ion binding]; other site 264198009699 G-X-G motif; other site 264198009700 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 264198009701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198009702 active site 264198009703 phosphorylation site [posttranslational modification] 264198009704 intermolecular recognition site; other site 264198009705 dimerization interface [polypeptide binding]; other site 264198009706 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198009707 Walker A motif; other site 264198009708 ATP binding site [chemical binding]; other site 264198009709 Walker B motif; other site 264198009710 arginine finger; other site 264198009711 Helix-turn-helix domains; Region: HTH; cl00088 264198009712 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 264198009713 DNA binding residues [nucleotide binding] 264198009714 ornithine cyclodeaminase; Validated; Region: PRK07589 264198009715 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198009716 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 264198009717 Amidinotransferase; Region: Amidinotransf; cl12043 264198009718 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264198009719 Helix-turn-helix domains; Region: HTH; cl00088 264198009720 AsnC family; Region: AsnC_trans_reg; pfam01037 264198009721 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 264198009722 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 264198009723 Cl- selectivity filter; other site 264198009724 Cl- binding residues [ion binding]; other site 264198009725 pore gating glutamate residue; other site 264198009726 dimer interface [polypeptide binding]; other site 264198009727 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 264198009728 FOG: CBS domain [General function prediction only]; Region: COG0517 264198009729 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 264198009730 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 264198009731 HPP family; Region: HPP; pfam04982 264198009732 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 264198009733 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 264198009734 Domain of unknown function DUF20; Region: UPF0118; pfam01594 264198009735 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 264198009736 Paraquat-inducible protein A; Region: PqiA; pfam04403 264198009737 Paraquat-inducible protein A; Region: PqiA; pfam04403 264198009738 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 264198009739 mce related protein; Region: MCE; pfam02470 264198009740 mce related protein; Region: MCE; pfam02470 264198009741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 264198009742 Protein of unknown function (DUF330); Region: DUF330; cl01135 264198009743 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 264198009744 multifunctional aminopeptidase A; Provisional; Region: PRK00913 264198009745 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 264198009746 interface (dimer of trimers) [polypeptide binding]; other site 264198009747 Substrate-binding/catalytic site; other site 264198009748 Zn-binding sites [ion binding]; other site 264198009749 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 264198009750 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 264198009751 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 264198009752 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 264198009753 putative active site [active] 264198009754 Predicted integral membrane protein (DUF2282); Region: DUF2282; cl02366 264198009755 Protein of unknown function (DUF692); Region: DUF692; cl01263 264198009756 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 264198009757 DoxX; Region: DoxX; cl00976 264198009758 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 264198009759 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 264198009760 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 264198009761 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 264198009762 CysD dimerization site [polypeptide binding]; other site 264198009763 G1 box; other site 264198009764 putative GEF interaction site [polypeptide binding]; other site 264198009765 GTP/Mg2+ binding site [chemical binding]; other site 264198009766 Switch I region; other site 264198009767 G2 box; other site 264198009768 G3 box; other site 264198009769 Switch II region; other site 264198009770 G4 box; other site 264198009771 G5 box; other site 264198009772 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 264198009773 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 264198009774 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 264198009775 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 264198009776 Active Sites [active] 264198009777 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 264198009778 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 264198009779 Active Sites [active] 264198009780 Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526 264198009781 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 264198009782 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 264198009783 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 264198009784 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 264198009785 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 264198009786 Helix-turn-helix domains; Region: HTH; cl00088 264198009787 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 264198009788 substrate binding site [chemical binding]; other site 264198009789 dimerization interface [polypeptide binding]; other site 264198009790 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 264198009791 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198009792 S-adenosylmethionine binding site [chemical binding]; other site 264198009793 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 264198009794 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 264198009795 putative ligand binding site [chemical binding]; other site 264198009796 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 264198009797 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198009798 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198009799 substrate binding pocket [chemical binding]; other site 264198009800 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 264198009801 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 264198009802 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 264198009803 Peptidase family M48; Region: Peptidase_M48; cl12018 264198009804 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 264198009805 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 264198009806 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 264198009807 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 264198009808 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 264198009809 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 264198009810 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 264198009811 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 264198009812 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 264198009813 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 264198009814 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198009815 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198009816 homodimer interface [polypeptide binding]; other site 264198009817 catalytic residue [active] 264198009818 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 264198009819 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 264198009820 putative active site [active] 264198009821 catalytic site [active] 264198009822 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 264198009823 putative active site [active] 264198009824 catalytic site [active] 264198009825 N-formylglutamate amidohydrolase; Region: FGase; cl01522 264198009826 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 264198009827 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198009828 active site 264198009829 imidazolonepropionase; Validated; Region: PRK09356 264198009830 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 264198009831 active site 264198009832 HutD; Region: HutD; cl01532 264198009833 urocanate hydratase; Provisional; Region: PRK05414 264198009834 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 264198009835 active sites [active] 264198009836 tetramer interface [polypeptide binding]; other site 264198009837 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 264198009838 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198009839 DNA-binding site [nucleotide binding]; DNA binding site 264198009840 UTRA domain; Region: UTRA; cl01230 264198009841 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 264198009842 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 264198009843 Walker A/P-loop; other site 264198009844 ATP binding site [chemical binding]; other site 264198009845 Q-loop/lid; other site 264198009846 ABC transporter signature motif; other site 264198009847 Walker B; other site 264198009848 D-loop; other site 264198009849 H-loop/switch region; other site 264198009850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198009851 dimer interface [polypeptide binding]; other site 264198009852 conserved gate region; other site 264198009853 putative PBP binding loops; other site 264198009854 ABC-ATPase subunit interface; other site 264198009855 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 264198009856 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198009857 substrate binding pocket [chemical binding]; other site 264198009858 membrane-bound complex binding site; other site 264198009859 hinge residues; other site 264198009860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198009861 NAD(P) binding site [chemical binding]; other site 264198009862 active site 264198009863 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 264198009864 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198009865 catalytic loop [active] 264198009866 iron binding site [ion binding]; other site 264198009867 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 264198009868 FAD binding pocket [chemical binding]; other site 264198009869 FAD binding motif [chemical binding]; other site 264198009870 phosphate binding motif [ion binding]; other site 264198009871 beta-alpha-beta structure motif; other site 264198009872 NAD binding pocket [chemical binding]; other site 264198009873 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 264198009874 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264198009875 inhibitor-cofactor binding pocket; inhibition site 264198009876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198009877 catalytic residue [active] 264198009878 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl08302 264198009879 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264198009880 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 264198009881 Walker A/P-loop; other site 264198009882 ATP binding site [chemical binding]; other site 264198009883 Q-loop/lid; other site 264198009884 ABC transporter signature motif; other site 264198009885 Walker B; other site 264198009886 D-loop; other site 264198009887 H-loop/switch region; other site 264198009888 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198009889 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 264198009890 Walker A/P-loop; other site 264198009891 ATP binding site [chemical binding]; other site 264198009892 Q-loop/lid; other site 264198009893 ABC transporter signature motif; other site 264198009894 Walker B; other site 264198009895 D-loop; other site 264198009896 H-loop/switch region; other site 264198009897 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198009898 TM-ABC transporter signature motif; other site 264198009899 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198009900 TM-ABC transporter signature motif; other site 264198009901 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 264198009902 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 264198009903 dimerization interface [polypeptide binding]; other site 264198009904 ligand binding site [chemical binding]; other site 264198009905 LytB protein; Region: LYTB; cl00507 264198009906 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 264198009907 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 264198009908 hypothetical protein; Reviewed; Region: PRK00024 264198009909 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 264198009910 MPN+ (JAMM) motif; other site 264198009911 Zinc-binding site [ion binding]; other site 264198009912 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 264198009913 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 264198009914 L-aspartate oxidase; Provisional; Region: PRK09077 264198009915 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198009916 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 264198009917 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978 264198009918 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 264198009919 dimerization interface [polypeptide binding]; other site 264198009920 active site 264198009921 Quinolinate synthetase A protein; Region: NadA; cl00420 264198009922 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 264198009923 Di-iron ligands [ion binding]; other site 264198009924 Transposase; Region: DDE_Tnp_ISL3; pfam01610 264198009925 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 264198009926 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264198009927 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 264198009928 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198009929 S-adenosylmethionine binding site [chemical binding]; other site 264198009930 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 264198009931 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 264198009932 active site 264198009933 substrate binding site [chemical binding]; other site 264198009934 cosubstrate binding site; other site 264198009935 catalytic site [active] 264198009936 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198009937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198009938 active site 264198009939 phosphorylation site [posttranslational modification] 264198009940 intermolecular recognition site; other site 264198009941 dimerization interface [polypeptide binding]; other site 264198009942 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198009943 DNA binding residues [nucleotide binding] 264198009944 dimerization interface [polypeptide binding]; other site 264198009945 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 264198009946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198009947 ATP binding site [chemical binding]; other site 264198009948 Mg2+ binding site [ion binding]; other site 264198009949 G-X-G motif; other site 264198009950 Response regulator receiver domain; Region: Response_reg; pfam00072 264198009951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198009952 active site 264198009953 phosphorylation site [posttranslational modification] 264198009954 intermolecular recognition site; other site 264198009955 dimerization interface [polypeptide binding]; other site 264198009956 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 264198009957 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 264198009958 active site 264198009959 Riboflavin kinase; Region: Flavokinase; cl03312 264198009960 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 264198009961 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264198009962 active site 264198009963 HIGH motif; other site 264198009964 nucleotide binding site [chemical binding]; other site 264198009965 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 264198009966 active site 264198009967 KMSKS motif; other site 264198009968 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 264198009969 tRNA binding surface [nucleotide binding]; other site 264198009970 anticodon binding site; other site 264198009971 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 264198009972 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 264198009973 lipoprotein signal peptidase; Provisional; Region: PRK14787 264198009974 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 264198009975 Flavoprotein; Region: Flavoprotein; cl08021 264198009976 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 264198009977 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 264198009978 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 264198009979 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 264198009980 trimer interface [polypeptide binding]; other site 264198009981 active site 264198009982 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 264198009983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198009984 NMT1-like family; Region: NMT1_2; cl15260 264198009985 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 264198009986 Clp amino terminal domain; Region: Clp_N; pfam02861 264198009987 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198009988 Walker A motif; other site 264198009989 ATP binding site [chemical binding]; other site 264198009990 Walker B motif; other site 264198009991 arginine finger; other site 264198009992 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198009993 Walker A motif; other site 264198009994 ATP binding site [chemical binding]; other site 264198009995 Walker B motif; other site 264198009996 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 264198009997 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 264198009998 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 264198009999 DNA-binding site [nucleotide binding]; DNA binding site 264198010000 RNA-binding motif; other site 264198010001 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 264198010002 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198010003 isocitrate dehydrogenase; Validated; Region: PRK07362 264198010004 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 264198010005 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 264198010006 pseudouridine synthase; Region: TIGR00093 264198010007 active site 264198010008 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 264198010009 Protein of unknown function (DUF520); Region: DUF520; cl00723 264198010010 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 264198010011 FAD binding domain; Region: FAD_binding_4; pfam01565 264198010012 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 264198010013 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 264198010014 ornithine carbamoyltransferase; Provisional; Region: PRK00779 264198010015 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 264198010016 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198010017 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 264198010018 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 264198010019 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 264198010020 Uncharacterized conserved protein [Function unknown]; Region: COG2912 264198010021 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 264198010022 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 264198010023 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 264198010024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198010025 ATP binding site [chemical binding]; other site 264198010026 Mg2+ binding site [ion binding]; other site 264198010027 G-X-G motif; other site 264198010028 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 264198010029 ATP binding site [chemical binding]; other site 264198010030 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 264198010031 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 264198010032 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198010033 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 264198010034 Helix-turn-helix domains; Region: HTH; cl00088 264198010035 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198010036 dimerization interface [polypeptide binding]; other site 264198010037 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 264198010038 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 264198010039 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 264198010040 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 264198010041 dimerization interface [polypeptide binding]; other site 264198010042 putative ATP binding site [chemical binding]; other site 264198010043 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 264198010044 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198010045 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 264198010046 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 264198010047 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264198010048 poly(A) polymerase; Region: pcnB; TIGR01942 264198010049 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 264198010050 active site 264198010051 NTP binding site [chemical binding]; other site 264198010052 metal binding triad [ion binding]; metal-binding site 264198010053 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 264198010054 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 264198010055 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 264198010056 catalytic center binding site [active] 264198010057 ATP binding site [chemical binding]; other site 264198010058 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 264198010059 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 264198010060 Substrate-binding site [chemical binding]; other site 264198010061 Substrate specificity [chemical binding]; other site 264198010062 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 264198010063 oligomerization interface [polypeptide binding]; other site 264198010064 active site 264198010065 metal binding site [ion binding]; metal-binding site 264198010066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198010067 dimer interface [polypeptide binding]; other site 264198010068 conserved gate region; other site 264198010069 putative PBP binding loops; other site 264198010070 ABC-ATPase subunit interface; other site 264198010071 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 264198010072 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 264198010073 Walker A/P-loop; other site 264198010074 ATP binding site [chemical binding]; other site 264198010075 Q-loop/lid; other site 264198010076 ABC transporter signature motif; other site 264198010077 Walker B; other site 264198010078 D-loop; other site 264198010079 H-loop/switch region; other site 264198010080 chorismate binding enzyme; Region: Chorismate_bind; cl10555 264198010081 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 264198010082 substrate-cofactor binding pocket; other site 264198010083 homodimer interface [polypeptide binding]; other site 264198010084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198010085 catalytic residue [active] 264198010086 chaperone protein DnaJ; Provisional; Region: PRK10767 264198010087 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 264198010088 HSP70 interaction site [polypeptide binding]; other site 264198010089 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 264198010090 heme-binding residues [chemical binding]; other site 264198010091 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 264198010092 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 264198010093 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 264198010094 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 264198010095 D-lactate dehydrogenase [cytochrome]; Region: PLN02805 264198010096 FAD binding domain; Region: FAD_binding_4; pfam01565 264198010097 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 264198010098 Helix-turn-helix domains; Region: HTH; cl00088 264198010099 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 264198010100 dimerization interface [polypeptide binding]; other site 264198010101 substrate binding pocket [chemical binding]; other site 264198010102 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 264198010103 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264198010104 Coenzyme A binding pocket [chemical binding]; other site 264198010105 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 264198010106 FAD binding domain; Region: FAD_binding_4; pfam01565 264198010107 Ion transport protein; Region: Ion_trans; pfam00520 264198010108 Ion channel; Region: Ion_trans_2; cl11596 264198010109 Double zinc ribbon; Region: DZR; pfam12773 264198010110 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 264198010111 FAD binding domain; Region: FAD_binding_4; pfam01565 264198010112 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 264198010113 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 264198010114 Cysteine-rich domain; Region: CCG; pfam02754 264198010115 Cysteine-rich domain; Region: CCG; pfam02754 264198010116 LrgA family; Region: LrgA; cl00608 264198010117 LrgB-like family; Region: LrgB; cl00596 264198010118 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 264198010119 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198010120 Predicted transcriptional regulator [Transcription]; Region: COG2378 264198010121 Helix-turn-helix domains; Region: HTH; cl00088 264198010122 WYL domain; Region: WYL; cl14852 264198010123 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 264198010124 catalytic residues [active] 264198010125 dimer interface [polypeptide binding]; other site 264198010126 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 264198010127 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 264198010128 Walker A motif; other site 264198010129 ATP binding site [chemical binding]; other site 264198010130 Walker B motif; other site 264198010131 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 264198010132 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 264198010133 Walker A motif; other site 264198010134 ATP binding site [chemical binding]; other site 264198010135 Walker B motif; other site 264198010136 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 264198010137 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264198010138 catalytic residue [active] 264198010139 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 264198010140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198010141 UbiA prenyltransferase family; Region: UbiA; cl00337 264198010142 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 264198010143 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 264198010144 dimerization interface [polypeptide binding]; other site 264198010145 DPS ferroxidase diiron center [ion binding]; other site 264198010146 ion pore; other site 264198010147 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 264198010148 Helix-turn-helix domains; Region: HTH; cl00088 264198010149 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 264198010150 dimerization interface [polypeptide binding]; other site 264198010151 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 264198010152 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 264198010153 generic binding surface II; other site 264198010154 ssDNA binding site; other site 264198010155 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264198010156 ATP binding site [chemical binding]; other site 264198010157 putative Mg++ binding site [ion binding]; other site 264198010158 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264198010159 nucleotide binding region [chemical binding]; other site 264198010160 ATP-binding site [chemical binding]; other site 264198010161 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 264198010162 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 264198010163 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 264198010164 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 264198010165 Preprotein translocase subunit; Region: YajC; cl00806 264198010166 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 264198010167 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 264198010168 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 264198010169 Protein export membrane protein; Region: SecD_SecF; cl14618 264198010170 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 264198010171 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 264198010172 Protein export membrane protein; Region: SecD_SecF; cl14618 264198010173 Response regulator receiver domain; Region: Response_reg; pfam00072 264198010174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198010175 active site 264198010176 phosphorylation site [posttranslational modification] 264198010177 intermolecular recognition site; other site 264198010178 dimerization interface [polypeptide binding]; other site 264198010179 Response regulator receiver domain; Region: Response_reg; pfam00072 264198010180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198010181 active site 264198010182 phosphorylation site [posttranslational modification] 264198010183 intermolecular recognition site; other site 264198010184 dimerization interface [polypeptide binding]; other site 264198010185 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 264198010186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198010187 ATP binding site [chemical binding]; other site 264198010188 Mg2+ binding site [ion binding]; other site 264198010189 G-X-G motif; other site 264198010190 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198010191 dimer interface [polypeptide binding]; other site 264198010192 phosphorylation site [posttranslational modification] 264198010193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198010194 ATP binding site [chemical binding]; other site 264198010195 Mg2+ binding site [ion binding]; other site 264198010196 G-X-G motif; other site 264198010197 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 264198010198 YceI-like domain; Region: YceI; cl01001 264198010199 YceI-like domain; Region: YceI; cl01001 264198010200 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 264198010201 adenylosuccinate lyase; Provisional; Region: PRK09285 264198010202 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 264198010203 tetramer interface [polypeptide binding]; other site 264198010204 active site 264198010205 putative glutathione S-transferase; Provisional; Region: PRK10357 264198010206 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 264198010207 putative C-terminal domain interface [polypeptide binding]; other site 264198010208 putative GSH binding site (G-site) [chemical binding]; other site 264198010209 putative dimer interface [polypeptide binding]; other site 264198010210 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 264198010211 dimer interface [polypeptide binding]; other site 264198010212 N-terminal domain interface [polypeptide binding]; other site 264198010213 putative substrate binding pocket (H-site) [chemical binding]; other site 264198010214 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 264198010215 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 264198010216 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 264198010217 nudix motif; other site 264198010218 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 264198010219 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 264198010220 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198010221 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264198010222 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 264198010223 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 264198010224 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 264198010225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198010226 active site 264198010227 phosphorylation site [posttranslational modification] 264198010228 intermolecular recognition site; other site 264198010229 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 264198010230 THUMP domain; Region: THUMP; cl12076 264198010231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 264198010232 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 264198010233 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 264198010234 putative catalytic residue [active] 264198010235 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 264198010236 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 264198010237 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 264198010238 putative catalytic cysteine [active] 264198010239 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 264198010240 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 264198010241 Lipopolysaccharide-assembly; Region: LptE; cl01125 264198010242 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 264198010243 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 264198010244 HIGH motif; other site 264198010245 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 264198010246 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264198010247 active site 264198010248 KMSKS motif; other site 264198010249 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 264198010250 tRNA binding surface [nucleotide binding]; other site 264198010251 dihydrodipicolinate reductase; Provisional; Region: PRK00048 264198010252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198010253 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 264198010254 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 264198010255 ferric uptake regulator; Provisional; Region: fur; PRK09462 264198010256 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 264198010257 metal binding site 2 [ion binding]; metal-binding site 264198010258 putative DNA binding helix; other site 264198010259 metal binding site 1 [ion binding]; metal-binding site 264198010260 dimer interface [polypeptide binding]; other site 264198010261 structural Zn2+ binding site [ion binding]; other site 264198010262 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 264198010263 Helix-turn-helix domains; Region: HTH; cl00088 264198010264 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198010265 dimerization interface [polypeptide binding]; other site 264198010266 Flavin Reductases; Region: FlaRed; cl00801 264198010267 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198010268 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 264198010269 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 264198010270 transketolase; Reviewed; Region: PRK12753 264198010271 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 264198010272 TPP-binding site [chemical binding]; other site 264198010273 dimer interface [polypeptide binding]; other site 264198010274 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 264198010275 PYR/PP interface [polypeptide binding]; other site 264198010276 dimer interface [polypeptide binding]; other site 264198010277 TPP binding site [chemical binding]; other site 264198010278 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 264198010279 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 264198010280 putative dimer interface [polypeptide binding]; other site 264198010281 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198010282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 264198010283 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 264198010284 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 264198010285 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 264198010286 putative RNAase interaction site [polypeptide binding]; other site 264198010287 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 264198010288 active site 264198010289 barstar interaction site; other site 264198010290 Malate dehydrogenase enzyme; Region: Malate_DH; pfam12434 264198010291 malic enzyme; Reviewed; Region: PRK12862 264198010292 Malic enzyme, N-terminal domain; Region: malic; pfam00390 264198010293 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 264198010294 putative NAD(P) binding site [chemical binding]; other site 264198010295 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 264198010296 thiamine monophosphate kinase; Provisional; Region: PRK05731 264198010297 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 264198010298 ATP binding site [chemical binding]; other site 264198010299 dimerization interface [polypeptide binding]; other site 264198010300 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 264198010301 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 264198010302 tetramer interfaces [polypeptide binding]; other site 264198010303 beta-alpha-beta structure motif; other site 264198010304 binuclear metal-binding site [ion binding]; other site 264198010305 Competence-damaged protein; Region: CinA; cl00666 264198010306 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 264198010307 active site 264198010308 dimer interface [polypeptide binding]; other site 264198010309 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 264198010310 EamA-like transporter family; Region: EamA; cl01037 264198010311 EamA-like transporter family; Region: EamA; cl01037 264198010312 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 264198010313 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 264198010314 Transglycosylase; Region: Transgly; cl07896 264198010315 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 264198010316 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 264198010317 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 264198010318 shikimate binding site; other site 264198010319 NAD(P) binding site [chemical binding]; other site 264198010320 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 264198010321 Gram-negative bacterial tonB protein; Region: TonB; cl10048 264198010322 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 264198010323 RNB domain; Region: RNB; pfam00773 264198010324 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198010325 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198010326 NAD(P) binding site [chemical binding]; other site 264198010327 active site 264198010328 UTRA domain; Region: UTRA; cl01230 264198010329 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 264198010330 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 264198010331 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 264198010332 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264198010333 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264198010334 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 264198010335 catalytic residues [active] 264198010336 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 264198010337 trimer interface [polypeptide binding]; other site 264198010338 active site 264198010339 dimer interface [polypeptide binding]; other site 264198010340 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 264198010341 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264198010342 carboxyltransferase (CT) interaction site; other site 264198010343 biotinylation site [posttranslational modification]; other site 264198010344 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 264198010345 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264198010346 ATP-grasp domain; Region: ATP-grasp_4; cl03087 264198010347 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 264198010348 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 264198010349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198010350 S-adenosylmethionine binding site [chemical binding]; other site 264198010351 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 264198010352 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 264198010353 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 264198010354 dimer interface [polypeptide binding]; other site 264198010355 catalytic triad [active] 264198010356 peroxidatic and resolving cysteines [active] 264198010357 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 264198010358 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 264198010359 substrate binding site [chemical binding]; other site 264198010360 ATP binding site [chemical binding]; other site 264198010361 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 264198010362 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 264198010363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198010364 NMT1-like family; Region: NMT1_2; cl15260 264198010365 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 264198010366 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264198010367 N-terminal plug; other site 264198010368 ligand-binding site [chemical binding]; other site 264198010369 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 264198010370 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 264198010371 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 264198010372 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264198010373 N-terminal plug; other site 264198010374 ligand-binding site [chemical binding]; other site 264198010375 Helix-turn-helix domains; Region: HTH; cl00088 264198010376 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 264198010377 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 264198010378 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 264198010379 active site 264198010380 catalytic tetrad [active] 264198010381 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 264198010382 Putative exonuclease, RdgC; Region: RdgC; cl01122 264198010383 Transmembrane secretion effector; Region: MFS_3; pfam05977 264198010384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198010385 putative substrate translocation pore; other site 264198010386 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 264198010387 active site 264198010388 Oxygen tolerance; Region: BatD; pfam13584 264198010389 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 264198010390 metal ion-dependent adhesion site (MIDAS); other site 264198010391 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264198010392 Tetratricopeptide repeat; Region: TPR_16; pfam13432 264198010393 TPR motif; other site 264198010394 binding surface 264198010395 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 264198010396 metal ion-dependent adhesion site (MIDAS); other site 264198010397 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 264198010398 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 264198010399 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 264198010400 MoxR-like ATPases [General function prediction only]; Region: COG0714 264198010401 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198010402 spermidine synthase; Provisional; Region: PRK03612 264198010403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 264198010404 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 264198010405 Sulfatase; Region: Sulfatase; cl10460 264198010406 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 264198010407 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264198010408 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264198010409 motif II; other site 264198010410 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 264198010411 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 264198010412 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 264198010413 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 264198010414 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 264198010415 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 264198010416 dinuclear metal binding motif [ion binding]; other site 264198010417 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 264198010418 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 264198010419 DNA binding residues [nucleotide binding] 264198010420 putative dimer interface [polypeptide binding]; other site 264198010421 putative metal binding residues [ion binding]; other site 264198010422 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 264198010423 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 264198010424 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 264198010425 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 264198010426 enoyl-CoA hydratase; Provisional; Region: PRK06144 264198010427 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198010428 substrate binding site [chemical binding]; other site 264198010429 oxyanion hole (OAH) forming residues; other site 264198010430 trimer interface [polypeptide binding]; other site 264198010431 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198010432 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198010433 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198010434 NMT1-like family; Region: NMT1_2; cl15260 264198010435 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198010436 Helix-turn-helix domains; Region: HTH; cl00088 264198010437 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198010438 dimerization interface [polypeptide binding]; other site 264198010439 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 264198010440 active site 264198010441 metal binding site [ion binding]; metal-binding site 264198010442 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 264198010443 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 264198010444 Helix-turn-helix domains; Region: HTH; cl00088 264198010445 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 264198010446 dimerization interface [polypeptide binding]; other site 264198010447 substrate binding pocket [chemical binding]; other site 264198010448 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 264198010449 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264198010450 catalytic residue [active] 264198010451 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 264198010452 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 264198010453 Pyocin large subunit [General function prediction only]; Region: COG5529 264198010454 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 264198010455 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 264198010456 putative RNAase interaction site [polypeptide binding]; other site 264198010457 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 264198010458 active site 264198010459 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 264198010460 AsmA-like C-terminal region; Region: AsmA_2; cl15864 264198010461 haemagglutination activity domain; Region: Haemagg_act; cl05436 264198010462 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 264198010463 peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925 264198010464 PPIC-type PPIASE domain; Region: Rotamase; cl08278 264198010465 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 264198010466 Surface antigen; Region: Bac_surface_Ag; cl03097 264198010467 haemagglutination activity domain; Region: Haemagg_act; cl05436 264198010468 bifunctional D-alanyl-alanine synthetase A/UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: PRK14573 264198010469 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 264198010470 ligand binding site [chemical binding]; other site 264198010471 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 264198010472 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 264198010473 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 264198010474 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 264198010475 dimer interface [polypeptide binding]; other site 264198010476 putative radical transfer pathway; other site 264198010477 diiron center [ion binding]; other site 264198010478 tyrosyl radical; other site 264198010479 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 264198010480 ATP cone domain; Region: ATP-cone; pfam03477 264198010481 Class I ribonucleotide reductase; Region: RNR_I; cd01679 264198010482 active site 264198010483 dimer interface [polypeptide binding]; other site 264198010484 catalytic residues [active] 264198010485 effector binding site; other site 264198010486 R2 peptide binding site; other site 264198010487 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 264198010488 amidase catalytic site [active] 264198010489 Zn binding residues [ion binding]; other site 264198010490 substrate binding site [chemical binding]; other site 264198010491 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 264198010492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198010493 active site 264198010494 phosphorylation site [posttranslational modification] 264198010495 intermolecular recognition site; other site 264198010496 dimerization interface [polypeptide binding]; other site 264198010497 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198010498 Walker A motif; other site 264198010499 ATP binding site [chemical binding]; other site 264198010500 Walker B motif; other site 264198010501 arginine finger; other site 264198010502 Helix-turn-helix domains; Region: HTH; cl00088 264198010503 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198010504 dimer interface [polypeptide binding]; other site 264198010505 phosphorylation site [posttranslational modification] 264198010506 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198010507 ATP binding site [chemical binding]; other site 264198010508 Mg2+ binding site [ion binding]; other site 264198010509 G-X-G motif; other site 264198010510 FHIPEP family; Region: FHIPEP; pfam00771 264198010511 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 264198010512 signal recognition particle protein; Provisional; Region: PRK10867 264198010513 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 264198010514 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 264198010515 P loop; other site 264198010516 GTP binding site [chemical binding]; other site 264198010517 Signal peptide binding domain; Region: SRP_SPB; pfam02978 264198010518 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264198010519 active site 264198010520 LysE type translocator; Region: LysE; cl00565 264198010521 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 264198010522 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 264198010523 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 264198010524 N-acetyl-D-glucosamine binding site [chemical binding]; other site 264198010525 catalytic residue [active] 264198010526 prolyl-tRNA synthetase; Provisional; Region: PRK09194 264198010527 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 264198010528 dimer interface [polypeptide binding]; other site 264198010529 motif 1; other site 264198010530 active site 264198010531 motif 2; other site 264198010532 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 264198010533 putative deacylase active site [active] 264198010534 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 264198010535 active site 264198010536 motif 3; other site 264198010537 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 264198010538 anticodon binding site; other site 264198010539 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 264198010540 putative active site [active] 264198010541 Ap4A binding site [chemical binding]; other site 264198010542 nudix motif; other site 264198010543 putative metal binding site [ion binding]; other site 264198010544 CNP1-like family; Region: CNP1; pfam08750 264198010545 gamma-glutamyl kinase; Provisional; Region: PRK05429 264198010546 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 264198010547 nucleotide binding site [chemical binding]; other site 264198010548 homotetrameric interface [polypeptide binding]; other site 264198010549 putative phosphate binding site [ion binding]; other site 264198010550 putative allosteric binding site; other site 264198010551 PUA domain; Region: PUA; cl00607 264198010552 GTPase CgtA; Reviewed; Region: obgE; PRK12299 264198010553 GTP1/OBG; Region: GTP1_OBG; pfam01018 264198010554 Obg GTPase; Region: Obg; cd01898 264198010555 G1 box; other site 264198010556 GTP/Mg2+ binding site [chemical binding]; other site 264198010557 Switch I region; other site 264198010558 G2 box; other site 264198010559 G3 box; other site 264198010560 Switch II region; other site 264198010561 G4 box; other site 264198010562 G5 box; other site 264198010563 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 264198010564 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 264198010565 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 264198010566 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 264198010567 substrate binding pocket [chemical binding]; other site 264198010568 chain length determination region; other site 264198010569 substrate-Mg2+ binding site; other site 264198010570 catalytic residues [active] 264198010571 aspartate-rich region 1; other site 264198010572 active site lid residues [active] 264198010573 aspartate-rich region 2; other site 264198010574 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 264198010575 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 264198010576 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 264198010577 Walker A motif; other site 264198010578 ATP binding site [chemical binding]; other site 264198010579 Walker B motif; other site 264198010580 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 264198010581 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 264198010582 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 264198010583 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 264198010584 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 264198010585 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 264198010586 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 264198010587 CoA-binding site [chemical binding]; other site 264198010588 ATP-binding [chemical binding]; other site 264198010589 Protein of unknown function (DUF1342); Region: DUF1342; cl01892 264198010590 Domain of unknown function (DUF329); Region: DUF329; cl01144 264198010591 OPT oligopeptide transporter protein; Region: OPT; cl14607 264198010592 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 264198010593 active site 264198010594 8-oxo-dGMP binding site [chemical binding]; other site 264198010595 nudix motif; other site 264198010596 metal binding site [ion binding]; metal-binding site 264198010597 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 264198010598 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198010599 Walker A motif; other site 264198010600 ATP binding site [chemical binding]; other site 264198010601 Walker B motif; other site 264198010602 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 264198010603 heterotetramer interface [polypeptide binding]; other site 264198010604 active site pocket [active] 264198010605 cleavage site 264198010606 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 264198010607 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 264198010608 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264198010609 nucleotide binding region [chemical binding]; other site 264198010610 ATP-binding site [chemical binding]; other site 264198010611 SEC-C motif; Region: SEC-C; pfam02810 264198010612 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 264198010613 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 264198010614 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 264198010615 catalytic triad [active] 264198010616 dimer interface [polypeptide binding]; other site 264198010617 cell division protein FtsZ; Validated; Region: PRK09330 264198010618 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 264198010619 nucleotide binding site [chemical binding]; other site 264198010620 SulA interaction site; other site 264198010621 cell division protein FtsA; Region: ftsA; TIGR01174 264198010622 Cell division protein FtsA; Region: FtsA; cl11496 264198010623 Cell division protein FtsA; Region: FtsA; cl11496 264198010624 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 264198010625 Cell division protein FtsQ; Region: FtsQ; pfam03799 264198010626 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 264198010627 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 264198010628 ATP-grasp domain; Region: ATP-grasp_4; cl03087 264198010629 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 264198010630 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 264198010631 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264198010632 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264198010633 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 264198010634 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 264198010635 active site 264198010636 homodimer interface [polypeptide binding]; other site 264198010637 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 264198010638 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006 264198010639 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264198010640 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264198010641 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 264198010642 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 264198010643 Mg++ binding site [ion binding]; other site 264198010644 putative catalytic motif [active] 264198010645 putative substrate binding site [chemical binding]; other site 264198010646 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 264198010647 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 264198010648 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264198010649 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264198010650 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 264198010651 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 264198010652 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264198010653 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 264198010654 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 264198010655 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 264198010656 Septum formation initiator; Region: DivIC; cl11433 264198010657 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 264198010658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 264198010659 cell division protein MraZ; Reviewed; Region: PRK00326 264198010660 MraZ protein; Region: MraZ; pfam02381 264198010661 MraZ protein; Region: MraZ; pfam02381 264198010662 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 264198010663 diiron binding motif [ion binding]; other site 264198010664 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198010665 trimer interface [polypeptide binding]; other site 264198010666 eyelet of channel; other site 264198010667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198010668 NMT1-like family; Region: NMT1_2; cl15260 264198010669 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264198010670 Helix-turn-helix domains; Region: HTH; cl00088 264198010671 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 264198010672 AMP-binding enzyme; Region: AMP-binding; cl15778 264198010673 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198010674 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198010675 Helix-turn-helix domains; Region: HTH; cl00088 264198010676 acyl-CoA synthetase; Validated; Region: PRK06178 264198010677 AMP-binding enzyme; Region: AMP-binding; cl15778 264198010678 AMP-binding enzyme; Region: AMP-binding; cl15778 264198010679 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 264198010680 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264198010681 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 264198010682 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264198010683 carboxyltransferase (CT) interaction site; other site 264198010684 biotinylation site [posttranslational modification]; other site 264198010685 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 264198010686 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 264198010687 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 264198010688 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198010689 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 264198010690 putative ligand binding site [chemical binding]; other site 264198010691 Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023 264198010692 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 264198010693 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 264198010694 putative [4Fe-4S] binding site [ion binding]; other site 264198010695 putative molybdopterin cofactor binding site [chemical binding]; other site 264198010696 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 264198010697 putative molybdopterin cofactor binding site; other site 264198010698 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 264198010699 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 264198010700 putative ligand binding site [chemical binding]; other site 264198010701 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 264198010702 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 264198010703 Walker A/P-loop; other site 264198010704 ATP binding site [chemical binding]; other site 264198010705 Q-loop/lid; other site 264198010706 ABC transporter signature motif; other site 264198010707 Walker B; other site 264198010708 D-loop; other site 264198010709 H-loop/switch region; other site 264198010710 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 264198010711 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 264198010712 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 264198010713 Walker A/P-loop; other site 264198010714 ATP binding site [chemical binding]; other site 264198010715 Q-loop/lid; other site 264198010716 ABC transporter signature motif; other site 264198010717 Walker B; other site 264198010718 D-loop; other site 264198010719 H-loop/switch region; other site 264198010720 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 264198010721 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 264198010722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198010723 putative PBP binding loops; other site 264198010724 dimer interface [polypeptide binding]; other site 264198010725 ABC-ATPase subunit interface; other site 264198010726 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 264198010727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198010728 dimer interface [polypeptide binding]; other site 264198010729 conserved gate region; other site 264198010730 putative PBP binding loops; other site 264198010731 ABC-ATPase subunit interface; other site 264198010732 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 264198010733 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 264198010734 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 264198010735 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 264198010736 metal binding site [ion binding]; metal-binding site 264198010737 putative dimer interface [polypeptide binding]; other site 264198010738 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 264198010739 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 264198010740 enoyl-CoA hydratase; Provisional; Region: PRK05862 264198010741 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198010742 substrate binding site [chemical binding]; other site 264198010743 oxyanion hole (OAH) forming residues; other site 264198010744 trimer interface [polypeptide binding]; other site 264198010745 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 264198010746 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 264198010747 putative active site [active] 264198010748 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 264198010749 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 264198010750 Walker A/P-loop; other site 264198010751 ATP binding site [chemical binding]; other site 264198010752 Q-loop/lid; other site 264198010753 ABC transporter signature motif; other site 264198010754 Walker B; other site 264198010755 D-loop; other site 264198010756 H-loop/switch region; other site 264198010757 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 264198010758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198010759 dimer interface [polypeptide binding]; other site 264198010760 conserved gate region; other site 264198010761 putative PBP binding loops; other site 264198010762 ABC-ATPase subunit interface; other site 264198010763 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264198010764 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198010765 substrate binding pocket [chemical binding]; other site 264198010766 membrane-bound complex binding site; other site 264198010767 hinge residues; other site 264198010768 enoyl-CoA hydratase; Provisional; Region: PRK08140 264198010769 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198010770 substrate binding site [chemical binding]; other site 264198010771 oxyanion hole (OAH) forming residues; other site 264198010772 trimer interface [polypeptide binding]; other site 264198010773 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 264198010774 CoenzymeA binding site [chemical binding]; other site 264198010775 subunit interaction site [polypeptide binding]; other site 264198010776 PHB binding site; other site 264198010777 AMP-binding enzyme; Region: AMP-binding; cl15778 264198010778 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 264198010779 MltA specific insert domain; Region: MltA; cl08398 264198010780 3D domain; Region: 3D; cl01439 264198010781 Protein of unknown function (DUF525); Region: DUF525; cl01119 264198010782 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 264198010783 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 264198010784 substrate binding site [chemical binding]; other site 264198010785 hexamer interface [polypeptide binding]; other site 264198010786 metal binding site [ion binding]; metal-binding site 264198010787 phosphoglycolate phosphatase; Provisional; Region: PRK13222 264198010788 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264198010789 motif II; other site 264198010790 anthranilate synthase component I; Provisional; Region: PRK13565 264198010791 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 264198010792 chorismate binding enzyme; Region: Chorismate_bind; cl10555 264198010793 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 264198010794 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 264198010795 glutamine binding [chemical binding]; other site 264198010796 catalytic triad [active] 264198010797 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 264198010798 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 264198010799 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 264198010800 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 264198010801 active site 264198010802 ribulose/triose binding site [chemical binding]; other site 264198010803 phosphate binding site [ion binding]; other site 264198010804 substrate (anthranilate) binding pocket [chemical binding]; other site 264198010805 product (indole) binding pocket [chemical binding]; other site 264198010806 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 264198010807 putative active site [active] 264198010808 putative metal binding residues [ion binding]; other site 264198010809 signature motif; other site 264198010810 putative triphosphate binding site [ion binding]; other site 264198010811 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 264198010812 ligand binding site [chemical binding]; other site 264198010813 active site 264198010814 UGI interface [polypeptide binding]; other site 264198010815 catalytic site [active] 264198010816 Acylphosphatase; Region: Acylphosphatase; cl00551 264198010817 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 264198010818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198010819 dimer interface [polypeptide binding]; other site 264198010820 conserved gate region; other site 264198010821 putative PBP binding loops; other site 264198010822 ABC-ATPase subunit interface; other site 264198010823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198010824 dimer interface [polypeptide binding]; other site 264198010825 conserved gate region; other site 264198010826 putative PBP binding loops; other site 264198010827 ABC-ATPase subunit interface; other site 264198010828 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 264198010829 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 264198010830 Walker A/P-loop; other site 264198010831 ATP binding site [chemical binding]; other site 264198010832 Q-loop/lid; other site 264198010833 ABC transporter signature motif; other site 264198010834 Walker B; other site 264198010835 D-loop; other site 264198010836 H-loop/switch region; other site 264198010837 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; cl15413 264198010838 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 264198010839 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 264198010840 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 264198010841 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 264198010842 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 264198010843 protein binding site [polypeptide binding]; other site 264198010844 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 264198010845 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 264198010846 NADP binding site [chemical binding]; other site 264198010847 dimer interface [polypeptide binding]; other site 264198010848 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 264198010849 dimerization domain [polypeptide binding]; other site 264198010850 dimer interface [polypeptide binding]; other site 264198010851 catalytic residues [active] 264198010852 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198010853 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 264198010854 GTP-binding protein YchF; Reviewed; Region: PRK09601 264198010855 YchF GTPase; Region: YchF; cd01900 264198010856 G1 box; other site 264198010857 GTP/Mg2+ binding site [chemical binding]; other site 264198010858 Switch I region; other site 264198010859 G2 box; other site 264198010860 Switch II region; other site 264198010861 G3 box; other site 264198010862 G4 box; other site 264198010863 G5 box; other site 264198010864 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 264198010865 GDYXXLXY protein; Region: GDYXXLXY; cl02066 264198010866 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 264198010867 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 264198010868 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 264198010869 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 264198010870 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 264198010871 tRNA; other site 264198010872 putative tRNA binding site [nucleotide binding]; other site 264198010873 putative NADP binding site [chemical binding]; other site 264198010874 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 264198010875 peptide chain release factor 1; Validated; Region: prfA; PRK00591 264198010876 RF-1 domain; Region: RF-1; cl02875 264198010877 RF-1 domain; Region: RF-1; cl02875 264198010878 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 264198010879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198010880 S-adenosylmethionine binding site [chemical binding]; other site 264198010881 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 264198010882 putative GSH binding site [chemical binding]; other site 264198010883 catalytic residues [active] 264198010884 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 264198010885 Flavoprotein; Region: Flavoprotein; cl08021 264198010886 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198010887 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 264198010888 NAD(P) binding site [chemical binding]; other site 264198010889 catalytic residues [active] 264198010890 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 264198010891 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198010892 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264198010893 Helix-turn-helix domains; Region: HTH; cl00088 264198010894 AsnC family; Region: AsnC_trans_reg; pfam01037 264198010895 dihydrodipicolinate reductase; Provisional; Region: PRK00048 264198010896 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198010897 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 264198010898 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 264198010899 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 264198010900 putative ion selectivity filter; other site 264198010901 putative pore gating glutamate residue; other site 264198010902 putative H+/Cl- coupling transport residue; other site 264198010903 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198010904 NMT1-like family; Region: NMT1_2; cl15260 264198010905 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 264198010906 AMP-binding enzyme; Region: AMP-binding; cl15778 264198010907 LysR family transcriptional regulator; Provisional; Region: PRK14997 264198010908 Helix-turn-helix domains; Region: HTH; cl00088 264198010909 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198010910 putative effector binding pocket; other site 264198010911 dimerization interface [polypeptide binding]; other site 264198010912 Helix-turn-helix domains; Region: HTH; cl00088 264198010913 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 264198010914 MatE; Region: MatE; cl10513 264198010915 MatE; Region: MatE; cl10513 264198010916 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264198010917 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 264198010918 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264198010919 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198010920 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198010921 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 264198010922 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264198010923 putative active site [active] 264198010924 putative metal binding site [ion binding]; other site 264198010925 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 264198010926 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 264198010927 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 264198010928 ABC transporter; Region: ABC_tran_2; pfam12848 264198010929 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 264198010930 Protein of unknown function DUF45; Region: DUF45; cl00636 264198010931 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198010932 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198010933 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 264198010934 xanthine permease; Region: pbuX; TIGR03173 264198010935 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198010936 Helix-turn-helix domains; Region: HTH; cl00088 264198010937 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 264198010938 putative dimerization interface [polypeptide binding]; other site 264198010939 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 264198010940 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 264198010941 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 264198010942 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198010943 catalytic loop [active] 264198010944 iron binding site [ion binding]; other site 264198010945 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 264198010946 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 264198010947 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 264198010948 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264198010949 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 264198010950 Flavoprotein; Region: Flavoprotein; cl08021 264198010951 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 264198010952 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 264198010953 P-loop, Walker A motif; other site 264198010954 Base recognition motif; other site 264198010955 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 264198010956 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198010957 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198010958 xanthine permease; Region: pbuX; TIGR03173 264198010959 amidohydrolase; Provisional; Region: PRK12393 264198010960 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 264198010961 active site 264198010962 putative substrate binding pocket [chemical binding]; other site 264198010963 Cytochrome c; Region: Cytochrom_C; cl11414 264198010964 Cytochrome c; Region: Cytochrom_C; cl11414 264198010965 sulfite:cytochrome c oxidoreductase subunit A (SorA), molybdopterin binding domain. SorA is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SorB, a small c-type heme containing subunit, it forms a hetrodimer. It; Region: bact_SorA_Moco; cd02114 264198010966 sulfite oxidase; Provisional; Region: PLN00177 264198010967 Moco binding site; other site 264198010968 metal coordination site [ion binding]; other site 264198010969 putative dimerization interface [polypeptide binding]; other site 264198010970 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 264198010971 active site lid residues [active] 264198010972 substrate binding pocket [chemical binding]; other site 264198010973 catalytic residues [active] 264198010974 substrate-Mg2+ binding site; other site 264198010975 aspartate-rich region 1; other site 264198010976 aspartate-rich region 2; other site 264198010977 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 264198010978 Helix-turn-helix domains; Region: HTH; cl00088 264198010979 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 264198010980 putative dimerization interface [polypeptide binding]; other site 264198010981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198010982 NMT1-like family; Region: NMT1_2; cl15260 264198010983 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198010984 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198010985 enoyl-CoA hydratase; Provisional; Region: PRK06688 264198010986 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198010987 substrate binding site [chemical binding]; other site 264198010988 oxyanion hole (OAH) forming residues; other site 264198010989 trimer interface [polypeptide binding]; other site 264198010990 Stringent starvation protein B; Region: SspB; cl01120 264198010991 stringent starvation protein A; Provisional; Region: sspA; PRK09481 264198010992 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 264198010993 C-terminal domain interface [polypeptide binding]; other site 264198010994 putative GSH binding site (G-site) [chemical binding]; other site 264198010995 dimer interface [polypeptide binding]; other site 264198010996 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 264198010997 dimer interface [polypeptide binding]; other site 264198010998 N-terminal domain interface [polypeptide binding]; other site 264198010999 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 264198011000 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 264198011001 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 264198011002 Qi binding site; other site 264198011003 intrachain domain interface; other site 264198011004 interchain domain interface [polypeptide binding]; other site 264198011005 heme bH binding site [chemical binding]; other site 264198011006 heme bL binding site [chemical binding]; other site 264198011007 Qo binding site; other site 264198011008 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 264198011009 interchain domain interface [polypeptide binding]; other site 264198011010 intrachain domain interface; other site 264198011011 Qi binding site; other site 264198011012 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 264198011013 Qo binding site; other site 264198011014 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 264198011015 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 264198011016 [2Fe-2S] cluster binding site [ion binding]; other site 264198011017 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 264198011018 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 264198011019 Uncharacterized conserved protein [Function unknown]; Region: COG0327 264198011020 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 264198011021 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 264198011022 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 264198011023 protein binding site [polypeptide binding]; other site 264198011024 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198011025 trimer interface [polypeptide binding]; other site 264198011026 eyelet of channel; other site 264198011027 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 264198011028 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 264198011029 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 264198011030 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 264198011031 nucleotide binding site/active site [active] 264198011032 HIT family signature motif; other site 264198011033 catalytic residue [active] 264198011034 Predicted membrane protein [Function unknown]; Region: COG3671 264198011035 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 264198011036 metal binding site [ion binding]; metal-binding site 264198011037 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 264198011038 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 264198011039 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 264198011040 substrate binding site [chemical binding]; other site 264198011041 glutamase interaction surface [polypeptide binding]; other site 264198011042 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 264198011043 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 264198011044 catalytic residues [active] 264198011045 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 264198011046 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 264198011047 putative active site [active] 264198011048 oxyanion strand; other site 264198011049 catalytic triad [active] 264198011050 MarC family integral membrane protein; Region: MarC; cl00919 264198011051 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 264198011052 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 264198011053 putative active site pocket [active] 264198011054 4-fold oligomerization interface [polypeptide binding]; other site 264198011055 metal binding residues [ion binding]; metal-binding site 264198011056 3-fold/trimer interface [polypeptide binding]; other site 264198011057 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 264198011058 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198011059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198011060 homodimer interface [polypeptide binding]; other site 264198011061 catalytic residue [active] 264198011062 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 264198011063 histidinol dehydrogenase; Region: hisD; TIGR00069 264198011064 NAD binding site [chemical binding]; other site 264198011065 dimerization interface [polypeptide binding]; other site 264198011066 product binding site; other site 264198011067 substrate binding site [chemical binding]; other site 264198011068 zinc binding site [ion binding]; other site 264198011069 catalytic residues [active] 264198011070 ATP phosphoribosyltransferase; Region: HisG; cl15266 264198011071 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 264198011072 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 264198011073 hinge; other site 264198011074 active site 264198011075 BolA-like protein; Region: BolA; cl00386 264198011076 ABC-2 type transporter; Region: ABC2_membrane; cl11417 264198011077 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 264198011078 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 264198011079 Walker A/P-loop; other site 264198011080 ATP binding site [chemical binding]; other site 264198011081 Q-loop/lid; other site 264198011082 ABC transporter signature motif; other site 264198011083 Walker B; other site 264198011084 D-loop; other site 264198011085 H-loop/switch region; other site 264198011086 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 264198011087 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 264198011088 VacJ like lipoprotein; Region: VacJ; cl01073 264198011089 mce related protein; Region: MCE; pfam02470 264198011090 Permease; Region: Permease; cl00510 264198011091 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 264198011092 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 264198011093 Walker A/P-loop; other site 264198011094 ATP binding site [chemical binding]; other site 264198011095 Q-loop/lid; other site 264198011096 ABC transporter signature motif; other site 264198011097 Walker B; other site 264198011098 D-loop; other site 264198011099 H-loop/switch region; other site 264198011100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198011101 NMT1-like family; Region: NMT1_2; cl15260 264198011102 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 264198011103 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 264198011104 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 264198011105 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198011106 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 264198011107 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 264198011108 active site 264198011109 dimer interface [polypeptide binding]; other site 264198011110 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 264198011111 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 264198011112 active site 264198011113 FMN binding site [chemical binding]; other site 264198011114 substrate binding site [chemical binding]; other site 264198011115 3Fe-4S cluster binding site [ion binding]; other site 264198011116 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 264198011117 domain interface; other site 264198011118 Transposase IS200 like; Region: Y1_Tnp; cl00848 264198011119 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 264198011120 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264198011121 Zn2+ binding site [ion binding]; other site 264198011122 Mg2+ binding site [ion binding]; other site 264198011123 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 264198011124 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 264198011125 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 264198011126 active site 264198011127 dimer interface [polypeptide binding]; other site 264198011128 metal binding site [ion binding]; metal-binding site 264198011129 shikimate kinase; Reviewed; Region: aroK; PRK00131 264198011130 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 264198011131 ADP binding site [chemical binding]; other site 264198011132 magnesium binding site [ion binding]; other site 264198011133 putative shikimate binding site; other site 264198011134 AMIN domain; Region: AMIN; pfam11741 264198011135 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 264198011136 Secretin and TonB N terminus short domain; Region: STN; cl06624 264198011137 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 264198011138 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 264198011139 Pilus assembly protein, PilP; Region: PilP; pfam04351 264198011140 Pilus assembly protein, PilO; Region: PilO; cl01234 264198011141 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 264198011142 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 264198011143 Cell division protein FtsA; Region: FtsA; cl11496 264198011144 Competence protein A; Region: Competence_A; pfam11104 264198011145 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 264198011146 Transglycosylase; Region: Transgly; cl07896 264198011147 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 264198011148 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in...; Region: Frataxin; cl00238 264198011149 putative iron binding site [ion binding]; other site 264198011150 diaminopimelate decarboxylase; Region: lysA; TIGR01048 264198011151 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 264198011152 active site 264198011153 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264198011154 substrate binding site [chemical binding]; other site 264198011155 catalytic residues [active] 264198011156 dimer interface [polypeptide binding]; other site 264198011157 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 264198011158 TMAO/DMSO reductase; Reviewed; Region: PRK05363 264198011159 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 264198011160 Moco binding site; other site 264198011161 metal coordination site [ion binding]; other site 264198011162 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 264198011163 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 264198011164 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264198011165 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264198011166 DNA binding residues [nucleotide binding] 264198011167 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 264198011168 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 264198011169 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 264198011170 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 264198011171 Cytochrome c; Region: Cytochrom_C; cl11414 264198011172 Cytochrome c; Region: Cytochrom_C; cl11414 264198011173 Predicted GTPase [General function prediction only]; Region: COG0218 264198011174 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 264198011175 G1 box; other site 264198011176 GTP/Mg2+ binding site [chemical binding]; other site 264198011177 Switch I region; other site 264198011178 G2 box; other site 264198011179 G3 box; other site 264198011180 Switch II region; other site 264198011181 G4 box; other site 264198011182 G5 box; other site 264198011183 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 264198011184 dimer interface [polypeptide binding]; other site 264198011185 active site 264198011186 aspartate-rich active site metal binding site; other site 264198011187 allosteric magnesium binding site [ion binding]; other site 264198011188 Schiff base residues; other site 264198011189 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 264198011190 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 264198011191 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 264198011192 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 264198011193 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 264198011194 DsbD alpha interface [polypeptide binding]; other site 264198011195 catalytic residues [active] 264198011196 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 264198011197 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 264198011198 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 264198011199 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 264198011200 alphaNTD homodimer interface [polypeptide binding]; other site 264198011201 alphaNTD - beta interaction site [polypeptide binding]; other site 264198011202 alphaNTD - beta' interaction site [polypeptide binding]; other site 264198011203 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 264198011204 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 264198011205 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 264198011206 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264198011207 RNA binding surface [nucleotide binding]; other site 264198011208 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 264198011209 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 264198011210 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 264198011211 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 264198011212 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 264198011213 SecY translocase; Region: SecY; pfam00344 264198011214 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 264198011215 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 264198011216 23S rRNA binding site [nucleotide binding]; other site 264198011217 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 264198011218 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 264198011219 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 264198011220 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 264198011221 5S rRNA interface [nucleotide binding]; other site 264198011222 L27 interface [polypeptide binding]; other site 264198011223 23S rRNA interface [nucleotide binding]; other site 264198011224 L5 interface [polypeptide binding]; other site 264198011225 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 264198011226 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 264198011227 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 264198011228 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 264198011229 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 264198011230 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 264198011231 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 264198011232 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 264198011233 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 264198011234 KOW motif; Region: KOW; cl00354 264198011235 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 264198011236 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 264198011237 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 264198011238 23S rRNA interface [nucleotide binding]; other site 264198011239 putative translocon interaction site; other site 264198011240 signal recognition particle (SRP54) interaction site; other site 264198011241 L23 interface [polypeptide binding]; other site 264198011242 trigger factor interaction site; other site 264198011243 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 264198011244 23S rRNA interface [nucleotide binding]; other site 264198011245 5S rRNA interface [nucleotide binding]; other site 264198011246 putative antibiotic binding site [chemical binding]; other site 264198011247 L25 interface [polypeptide binding]; other site 264198011248 L27 interface [polypeptide binding]; other site 264198011249 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 264198011250 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 264198011251 G-X-X-G motif; other site 264198011252 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 264198011253 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 264198011254 putative translocon binding site; other site 264198011255 protein-rRNA interface [nucleotide binding]; other site 264198011256 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 264198011257 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 264198011258 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 264198011259 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 264198011260 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 264198011261 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 264198011262 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 264198011263 Dienelactone hydrolase family; Region: DLH; pfam01738 264198011264 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 264198011265 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 264198011266 elongation factor Tu; Reviewed; Region: PRK00049 264198011267 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 264198011268 G1 box; other site 264198011269 GEF interaction site [polypeptide binding]; other site 264198011270 GTP/Mg2+ binding site [chemical binding]; other site 264198011271 Switch I region; other site 264198011272 G2 box; other site 264198011273 G3 box; other site 264198011274 Switch II region; other site 264198011275 G4 box; other site 264198011276 G5 box; other site 264198011277 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 264198011278 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 264198011279 Antibiotic Binding Site [chemical binding]; other site 264198011280 elongation factor G; Reviewed; Region: PRK00007 264198011281 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 264198011282 G1 box; other site 264198011283 putative GEF interaction site [polypeptide binding]; other site 264198011284 GTP/Mg2+ binding site [chemical binding]; other site 264198011285 Switch I region; other site 264198011286 G2 box; other site 264198011287 G3 box; other site 264198011288 Switch II region; other site 264198011289 G4 box; other site 264198011290 G5 box; other site 264198011291 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 264198011292 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 264198011293 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 264198011294 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 264198011295 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 264198011296 S17 interaction site [polypeptide binding]; other site 264198011297 S8 interaction site; other site 264198011298 16S rRNA interaction site [nucleotide binding]; other site 264198011299 streptomycin interaction site [chemical binding]; other site 264198011300 23S rRNA interaction site [nucleotide binding]; other site 264198011301 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 264198011302 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 264198011303 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264198011304 ATP binding site [chemical binding]; other site 264198011305 putative Mg++ binding site [ion binding]; other site 264198011306 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264198011307 nucleotide binding region [chemical binding]; other site 264198011308 ATP-binding site [chemical binding]; other site 264198011309 RQC domain; Region: RQC; cl09632 264198011310 HRDC domain; Region: HRDC; cl02578 264198011311 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 264198011312 putative deacylase active site [active] 264198011313 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 264198011314 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 264198011315 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 264198011316 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 264198011317 DNA-directed RNA polymerase, beta'' subunit; Region: rpoC2_cyan; TIGR02388 264198011318 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 264198011319 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 264198011320 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 264198011321 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 264198011322 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 264198011323 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 264198011324 DNA binding site [nucleotide binding] 264198011325 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 264198011326 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 264198011327 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 264198011328 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 264198011329 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 264198011330 RPB11 interaction site [polypeptide binding]; other site 264198011331 RPB12 interaction site [polypeptide binding]; other site 264198011332 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 264198011333 RPB3 interaction site [polypeptide binding]; other site 264198011334 RPB1 interaction site [polypeptide binding]; other site 264198011335 RPB11 interaction site [polypeptide binding]; other site 264198011336 RPB10 interaction site [polypeptide binding]; other site 264198011337 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 264198011338 core dimer interface [polypeptide binding]; other site 264198011339 peripheral dimer interface [polypeptide binding]; other site 264198011340 L10 interface [polypeptide binding]; other site 264198011341 L11 interface [polypeptide binding]; other site 264198011342 putative EF-Tu interaction site [polypeptide binding]; other site 264198011343 putative EF-G interaction site [polypeptide binding]; other site 264198011344 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 264198011345 23S rRNA interface [nucleotide binding]; other site 264198011346 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 264198011347 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 264198011348 mRNA/rRNA interface [nucleotide binding]; other site 264198011349 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 264198011350 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 264198011351 23S rRNA interface [nucleotide binding]; other site 264198011352 L7/L12 interface [polypeptide binding]; other site 264198011353 putative thiostrepton binding site; other site 264198011354 L25 interface [polypeptide binding]; other site 264198011355 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 264198011356 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 264198011357 putative homodimer interface [polypeptide binding]; other site 264198011358 KOW motif; Region: KOW; cl00354 264198011359 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 264198011360 elongation factor Tu; Reviewed; Region: PRK00049 264198011361 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 264198011362 G1 box; other site 264198011363 GEF interaction site [polypeptide binding]; other site 264198011364 GTP/Mg2+ binding site [chemical binding]; other site 264198011365 Switch I region; other site 264198011366 G2 box; other site 264198011367 G3 box; other site 264198011368 Switch II region; other site 264198011369 G4 box; other site 264198011370 G5 box; other site 264198011371 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 264198011372 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 264198011373 Antibiotic Binding Site [chemical binding]; other site 264198011374 Protein of unknown function, DUF488; Region: DUF488; cl01246 264198011375 Nucleoside recognition; Region: Gate; cl00486 264198011376 Nucleoside recognition; Region: Gate; cl00486 264198011377 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 264198011378 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 264198011379 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198011380 Ligand Binding Site [chemical binding]; other site 264198011381 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 264198011382 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 264198011383 putative catalytic site [active] 264198011384 putative metal binding site [ion binding]; other site 264198011385 putative phosphate binding site [ion binding]; other site 264198011386 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 264198011387 phospholipase D; Region: PLN02866 264198011388 putative active site [active] 264198011389 catalytic site [active] 264198011390 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 264198011391 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 264198011392 putative active site [active] 264198011393 putative active site [active] 264198011394 catalytic site [active] 264198011395 catalytic site [active] 264198011396 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 264198011397 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 264198011398 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 264198011399 Phenylacetic acid degradation B; Region: PaaB; cl01371 264198011400 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 264198011401 Domain of unknown function DUF59; Region: DUF59; cl00941 264198011402 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 264198011403 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 264198011404 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 264198011405 FAD binding pocket [chemical binding]; other site 264198011406 FAD binding motif [chemical binding]; other site 264198011407 phosphate binding motif [ion binding]; other site 264198011408 beta-alpha-beta structure motif; other site 264198011409 NAD(p) ribose binding residues [chemical binding]; other site 264198011410 NAD binding pocket [chemical binding]; other site 264198011411 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 264198011412 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198011413 catalytic loop [active] 264198011414 iron binding site [ion binding]; other site 264198011415 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 264198011416 Protein of unknown function; Region: DUF3658; pfam12395 264198011417 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198011418 Helix-turn-helix domains; Region: HTH; cl00088 264198011419 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 264198011420 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 264198011421 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 264198011422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198011423 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 264198011424 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 264198011425 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264198011426 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264198011427 putative DNA binding site [nucleotide binding]; other site 264198011428 putative Zn2+ binding site [ion binding]; other site 264198011429 AsnC family; Region: AsnC_trans_reg; pfam01037 264198011430 EF-hand domain pair; Region: EF_hand_5; pfam13499 264198011431 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl08302 264198011432 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl08302 264198011433 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 264198011434 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 264198011435 heme-binding site [chemical binding]; other site 264198011436 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 264198011437 FAD binding pocket [chemical binding]; other site 264198011438 FAD binding motif [chemical binding]; other site 264198011439 phosphate binding motif [ion binding]; other site 264198011440 beta-alpha-beta structure motif; other site 264198011441 NAD binding pocket [chemical binding]; other site 264198011442 Heme binding pocket [chemical binding]; other site 264198011443 Predicted transcriptional regulator [Transcription]; Region: COG1959 264198011444 Helix-turn-helix domains; Region: HTH; cl00088 264198011445 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 264198011446 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 264198011447 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 264198011448 Type II transport protein GspH; Region: GspH; pfam12019 264198011449 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 264198011450 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 264198011451 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 264198011452 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 264198011453 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 264198011454 GspL periplasmic domain; Region: GspL_C; cl14909 264198011455 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 264198011456 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 264198011457 type II secretion system protein D; Region: type_II_gspD; TIGR02517 264198011458 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 264198011459 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 264198011460 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 264198011461 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 264198011462 type II secretion system protein E; Region: type_II_gspE; TIGR02533 264198011463 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 264198011464 Walker A motif; other site 264198011465 ATP binding site [chemical binding]; other site 264198011466 Walker B motif; other site 264198011467 type II secretion system protein F; Region: GspF; TIGR02120 264198011468 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 264198011469 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 264198011470 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 264198011471 putative metal binding site [ion binding]; other site 264198011472 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 264198011473 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 264198011474 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 264198011475 dimer interface [polypeptide binding]; other site 264198011476 PYR/PP interface [polypeptide binding]; other site 264198011477 TPP binding site [chemical binding]; other site 264198011478 substrate binding site [chemical binding]; other site 264198011479 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 264198011480 TPP-binding site; other site 264198011481 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 264198011482 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 264198011483 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 264198011484 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 264198011485 dimer interface [polypeptide binding]; other site 264198011486 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198011487 metal binding site [ion binding]; metal-binding site 264198011488 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198011489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198011490 putative substrate translocation pore; other site 264198011491 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 264198011492 putative active site [active] 264198011493 metal binding site [ion binding]; metal-binding site 264198011494 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 264198011495 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 264198011496 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 264198011497 Walker A/P-loop; other site 264198011498 ATP binding site [chemical binding]; other site 264198011499 Q-loop/lid; other site 264198011500 ABC transporter signature motif; other site 264198011501 Walker B; other site 264198011502 D-loop; other site 264198011503 H-loop/switch region; other site 264198011504 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 264198011505 Cation efflux family; Region: Cation_efflux; cl00316 264198011506 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264198011507 Helix-turn-helix domains; Region: HTH; cl00088 264198011508 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 264198011509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198011510 putative substrate translocation pore; other site 264198011511 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 264198011512 active site 264198011513 metal binding site [ion binding]; metal-binding site 264198011514 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 264198011515 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 264198011516 catalytic residues [active] 264198011517 DsrE/DsrF-like family; Region: DrsE; cl00672 264198011518 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 264198011519 Predicted secreted protein [Function unknown]; Region: COG5501 264198011520 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 264198011521 Cytochrome c; Region: Cytochrom_C; cl11414 264198011522 Cytochrome c; Region: Cytochrom_C; cl11414 264198011523 Cytochrome c; Region: Cytochrom_C; cl11414 264198011524 bacterial SoxC is a member of the sulfite oxidase (SO) family of molybdopterin binding domains. SoxC is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SoxD, a small c-type heme containing subunit, it forms a...; Region: bact_SoxC_Moco; cd02113 264198011525 Moco binding site; other site 264198011526 metal coordination site [ion binding]; other site 264198011527 dimerization interface [polypeptide binding]; other site 264198011528 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264198011529 dimerization interface [polypeptide binding]; other site 264198011530 putative DNA binding site [nucleotide binding]; other site 264198011531 putative Zn2+ binding site [ion binding]; other site 264198011532 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 264198011533 EamA-like transporter family; Region: EamA; cl01037 264198011534 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 264198011535 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198011536 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 264198011537 Cytochrome c; Region: Cytochrom_C; cl11414 264198011538 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 264198011539 BON domain; Region: BON; cl02771 264198011540 BON domain; Region: BON; cl02771 264198011541 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 264198011542 dimer interface [polypeptide binding]; other site 264198011543 active site 264198011544 Restriction endonuclease; Region: Mrr_cat; cl00516 264198011545 Predicted methyltransferases [General function prediction only]; Region: COG0313 264198011546 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 264198011547 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 264198011548 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264198011549 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 264198011550 ArsC family; Region: ArsC; pfam03960 264198011551 catalytic residues [active] 264198011552 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 264198011553 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 264198011554 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 264198011555 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264198011556 Coenzyme A binding pocket [chemical binding]; other site 264198011557 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 264198011558 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264198011559 Helix-turn-helix domains; Region: HTH; cl00088 264198011560 M20 Zn-peptidases include exopeptidases; Region: M20_like; cd02697 264198011561 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 264198011562 putative metal binding site [ion binding]; other site 264198011563 allantoate amidohydrolase; Reviewed; Region: PRK12890 264198011564 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 264198011565 active site 264198011566 metal binding site [ion binding]; metal-binding site 264198011567 dimer interface [polypeptide binding]; other site 264198011568 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 264198011569 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 264198011570 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264198011571 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198011572 DNA-binding site [nucleotide binding]; DNA binding site 264198011573 FCD domain; Region: FCD; cl11656 264198011574 short chain dehydrogenase; Provisional; Region: PRK07576 264198011575 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 264198011576 NAD(P) binding site [chemical binding]; other site 264198011577 substrate binding site [chemical binding]; other site 264198011578 homotetramer interface [polypeptide binding]; other site 264198011579 active site 264198011580 homodimer interface [polypeptide binding]; other site 264198011581 enoyl-CoA hydratase; Provisional; Region: PRK08140 264198011582 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198011583 substrate binding site [chemical binding]; other site 264198011584 oxyanion hole (OAH) forming residues; other site 264198011585 trimer interface [polypeptide binding]; other site 264198011586 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 264198011587 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 264198011588 AMP-binding enzyme; Region: AMP-binding; cl15778 264198011589 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198011590 enoyl-CoA hydratase; Provisional; Region: PRK07509 264198011591 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198011592 substrate binding site [chemical binding]; other site 264198011593 oxyanion hole (OAH) forming residues; other site 264198011594 trimer interface [polypeptide binding]; other site 264198011595 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 264198011596 Helix-turn-helix domains; Region: HTH; cl00088 264198011597 transcriptional activator TtdR; Provisional; Region: PRK09801 264198011598 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198011599 putative effector binding pocket; other site 264198011600 dimerization interface [polypeptide binding]; other site 264198011601 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 264198011602 Helix-turn-helix domains; Region: HTH; cl00088 264198011603 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198011604 dimerization interface [polypeptide binding]; other site 264198011605 citrate-proton symporter; Provisional; Region: PRK15075 264198011606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198011607 putative substrate translocation pore; other site 264198011608 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 264198011609 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 264198011610 metal binding site [ion binding]; metal-binding site 264198011611 putative dimer interface [polypeptide binding]; other site 264198011612 glyoxylate carboligase; Provisional; Region: PRK11269 264198011613 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 264198011614 PYR/PP interface [polypeptide binding]; other site 264198011615 dimer interface [polypeptide binding]; other site 264198011616 TPP binding site [chemical binding]; other site 264198011617 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 264198011618 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 264198011619 TPP-binding site [chemical binding]; other site 264198011620 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 264198011621 tartronate semialdehyde reductase; Provisional; Region: PRK15059 264198011622 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198011623 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 264198011624 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 264198011625 MOFRL family; Region: MOFRL; pfam05161 264198011626 pyruvate kinase; Provisional; Region: PRK06247 264198011627 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 264198011628 domain interfaces; other site 264198011629 active site 264198011630 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 264198011631 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 264198011632 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 264198011633 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 264198011634 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 264198011635 DNA binding residues [nucleotide binding] 264198011636 dimer interface [polypeptide binding]; other site 264198011637 putative metal binding site [ion binding]; other site 264198011638 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 264198011639 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 264198011640 Transcription initiation factor IIE, alpha subunit [Transcription]; Region: TFA1; COG1675 264198011641 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 264198011642 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 264198011643 Short C-terminal domain; Region: SHOCT; cl01373 264198011644 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 264198011645 spermidine synthase; Provisional; Region: PRK03612 264198011646 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198011647 S-adenosylmethionine binding site [chemical binding]; other site 264198011648 Peptidase family M48; Region: Peptidase_M48; cl12018 264198011649 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 264198011650 RF-1 domain; Region: RF-1; cl02875 264198011651 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 264198011652 catalytic residues [active] 264198011653 catalytic nucleophile [active] 264198011654 Recombinase; Region: Recombinase; pfam07508 264198011655 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 264198011656 catalytic residues [active] 264198011657 catalytic nucleophile [active] 264198011658 Presynaptic Site I dimer interface [polypeptide binding]; other site 264198011659 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 264198011660 Synaptic Flat tetramer interface [polypeptide binding]; other site 264198011661 Synaptic Site I dimer interface [polypeptide binding]; other site 264198011662 DNA binding site [nucleotide binding] 264198011663 Helix-turn-helix domains; Region: HTH; cl00088 264198011664 FAD binding domain; Region: FAD_binding_4; pfam01565 264198011665 Berberine and berberine like; Region: BBE; pfam08031 264198011666 MltA-interacting protein MipA; Region: MipA; cl01504 264198011667 Cytochrome c; Region: Cytochrom_C; cl11414 264198011668 Cytochrome c; Region: Cytochrom_C; cl11414 264198011669 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 264198011670 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264198011671 FeS/SAM binding site; other site 264198011672 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 264198011673 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264198011674 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198011675 dimer interface [polypeptide binding]; other site 264198011676 phosphorylation site [posttranslational modification] 264198011677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198011678 ATP binding site [chemical binding]; other site 264198011679 Mg2+ binding site [ion binding]; other site 264198011680 G-X-G motif; other site 264198011681 osmolarity response regulator; Provisional; Region: ompR; PRK09468 264198011682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198011683 active site 264198011684 phosphorylation site [posttranslational modification] 264198011685 intermolecular recognition site; other site 264198011686 dimerization interface [polypeptide binding]; other site 264198011687 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198011688 DNA binding site [nucleotide binding] 264198011689 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 264198011690 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198011691 Family description; Region: UvrD_C_2; cl15862 264198011692 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 264198011693 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 264198011694 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 264198011695 lipoyl attachment site [posttranslational modification]; other site 264198011696 glycine dehydrogenase; Provisional; Region: PRK05367 264198011697 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 264198011698 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198011699 tetramer interface [polypeptide binding]; other site 264198011700 catalytic residue [active] 264198011701 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 264198011702 tetramer interface [polypeptide binding]; other site 264198011703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198011704 catalytic residue [active] 264198011705 Protein of unknown function (DUF421); Region: DUF421; cl00990 264198011706 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 264198011707 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 264198011708 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 264198011709 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264198011710 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 264198011711 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 264198011712 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 264198011713 Tetratricopeptide repeat; Region: TPR_9; pfam13371 264198011714 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 264198011715 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 264198011716 dimerization interface [polypeptide binding]; other site 264198011717 ligand binding site [chemical binding]; other site 264198011718 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 264198011719 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 264198011720 Proline dehydrogenase; Region: Pro_dh; cl03282 264198011721 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 264198011722 Glutamate binding site [chemical binding]; other site 264198011723 NAD binding site [chemical binding]; other site 264198011724 catalytic residues [active] 264198011725 primosome assembly protein PriA; Validated; Region: PRK05580 264198011726 primosome assembly protein PriA; Validated; Region: PRK05580 264198011727 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264198011728 ATP binding site [chemical binding]; other site 264198011729 putative Mg++ binding site [ion binding]; other site 264198011730 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198011731 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 264198011732 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 264198011733 substrate binding site [chemical binding]; other site 264198011734 active site 264198011735 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 264198011736 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198011737 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 264198011738 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 264198011739 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 264198011740 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 264198011741 alpha subunit interaction interface [polypeptide binding]; other site 264198011742 Walker A motif; other site 264198011743 ATP binding site [chemical binding]; other site 264198011744 Walker B motif; other site 264198011745 inhibitor binding site; inhibition site 264198011746 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 264198011747 ATP synthase; Region: ATP-synt; cl00365 264198011748 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 264198011749 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 264198011750 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 264198011751 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 264198011752 beta subunit interaction interface [polypeptide binding]; other site 264198011753 Walker A motif; other site 264198011754 ATP binding site [chemical binding]; other site 264198011755 Walker B motif; other site 264198011756 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 264198011757 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 264198011758 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 264198011759 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 264198011760 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 264198011761 ATP synthase subunit C; Region: ATP-synt_C; cl00466 264198011762 ATP synthase A chain; Region: ATP-synt_A; cl00413 264198011763 ATP synthase I chain; Region: ATP_synt_I; cl09170 264198011764 ParB-like partition proteins; Region: parB_part; TIGR00180 264198011765 ParB-like nuclease domain; Region: ParBc; cl02129 264198011766 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 264198011767 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264198011768 P-loop; other site 264198011769 Magnesium ion binding site [ion binding]; other site 264198011770 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264198011771 Magnesium ion binding site [ion binding]; other site 264198011772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 264198011773 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 264198011774 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198011775 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 264198011776 N-formylglutamate amidohydrolase; Region: FGase; cl01522 264198011777 NMT1-like family; Region: NMT1_2; cl15260 264198011778 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 264198011779 Helix-turn-helix domains; Region: HTH; cl00088 264198011780 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 264198011781 dimerization interface [polypeptide binding]; other site 264198011782 substrate binding pocket [chemical binding]; other site 264198011783 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264198011784 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 264198011785 Walker A/P-loop; other site 264198011786 ATP binding site [chemical binding]; other site 264198011787 Q-loop/lid; other site 264198011788 ABC transporter signature motif; other site 264198011789 Walker B; other site 264198011790 D-loop; other site 264198011791 H-loop/switch region; other site 264198011792 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198011793 TM-ABC transporter signature motif; other site 264198011794 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198011795 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 264198011796 Walker A/P-loop; other site 264198011797 ATP binding site [chemical binding]; other site 264198011798 Q-loop/lid; other site 264198011799 ABC transporter signature motif; other site 264198011800 Walker B; other site 264198011801 D-loop; other site 264198011802 H-loop/switch region; other site 264198011803 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198011804 TM-ABC transporter signature motif; other site 264198011805 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 264198011806 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 264198011807 putative ligand binding site [chemical binding]; other site 264198011808 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 264198011809 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 264198011810 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198011811 TM-ABC transporter signature motif; other site 264198011812 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198011813 TM-ABC transporter signature motif; other site 264198011814 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198011815 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 264198011816 putative ligand binding site [chemical binding]; other site 264198011817 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264198011818 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 264198011819 Walker A/P-loop; other site 264198011820 ATP binding site [chemical binding]; other site 264198011821 Q-loop/lid; other site 264198011822 ABC transporter signature motif; other site 264198011823 Walker B; other site 264198011824 D-loop; other site 264198011825 H-loop/switch region; other site 264198011826 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198011827 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 264198011828 Walker A/P-loop; other site 264198011829 ATP binding site [chemical binding]; other site 264198011830 Q-loop/lid; other site 264198011831 ABC transporter signature motif; other site 264198011832 Walker B; other site 264198011833 D-loop; other site 264198011834 H-loop/switch region; other site 264198011835 choline dehydrogenase; Validated; Region: PRK02106 264198011836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198011837 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 264198011838 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198011839 Helix-turn-helix domains; Region: HTH; cl00088 264198011840 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264198011841 dimerization interface [polypeptide binding]; other site 264198011842 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 264198011843 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198011844 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 264198011845 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 264198011846 DNA binding residues [nucleotide binding] 264198011847 dimer interface [polypeptide binding]; other site 264198011848 copper binding site [ion binding]; other site 264198011849 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 264198011850 metal-binding site [ion binding] 264198011851 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 264198011852 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 264198011853 metal-binding site [ion binding] 264198011854 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264198011855 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264198011856 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 264198011857 metal-binding site [ion binding] 264198011858 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 264198011859 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 264198011860 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264198011861 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198011862 Helix-turn-helix domains; Region: HTH; cl00088 264198011863 ornithine cyclodeaminase; Validated; Region: PRK07340 264198011864 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198011865 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 264198011866 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 264198011867 active site 264198011868 catalytic tetrad [active] 264198011869 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 264198011870 Transglycosylase; Region: Transgly; cl07896 264198011871 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 264198011872 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 264198011873 YhhN-like protein; Region: YhhN; cl01505 264198011874 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 264198011875 MG2 domain; Region: A2M_N; pfam01835 264198011876 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 264198011877 Alpha-2-macroglobulin family; Region: A2M; pfam00207 264198011878 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264198011879 Helix-turn-helix domains; Region: HTH; cl00088 264198011880 AsnC family; Region: AsnC_trans_reg; pfam01037 264198011881 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 264198011882 cofactor binding site; other site 264198011883 metal binding site [ion binding]; metal-binding site 264198011884 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 264198011885 aromatic arch; other site 264198011886 DCoH dimer interaction site [polypeptide binding]; other site 264198011887 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 264198011888 DCoH tetramer interaction site [polypeptide binding]; other site 264198011889 substrate binding site [chemical binding]; other site 264198011890 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 264198011891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198011892 active site 264198011893 phosphorylation site [posttranslational modification] 264198011894 intermolecular recognition site; other site 264198011895 dimerization interface [polypeptide binding]; other site 264198011896 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198011897 DNA binding site [nucleotide binding] 264198011898 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 264198011899 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198011900 dimer interface [polypeptide binding]; other site 264198011901 phosphorylation site [posttranslational modification] 264198011902 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198011903 ATP binding site [chemical binding]; other site 264198011904 Mg2+ binding site [ion binding]; other site 264198011905 G-X-G motif; other site 264198011906 SET domain; Region: SET; cl02566 264198011907 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 264198011908 IHF dimer interface [polypeptide binding]; other site 264198011909 IHF - DNA interface [nucleotide binding]; other site 264198011910 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776 264198011911 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 264198011912 active site 264198011913 DNA polymerase IV; Validated; Region: PRK02406 264198011914 DNA binding site [nucleotide binding] 264198011915 Predicted permeases [General function prediction only]; Region: RarD; COG2962 264198011916 EamA-like transporter family; Region: EamA; cl01037 264198011917 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 264198011918 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 264198011919 trimer interface; other site 264198011920 sugar binding site [chemical binding]; other site 264198011921 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 264198011922 LysE type translocator; Region: LysE; cl00565 264198011923 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 264198011924 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198011925 metal binding site [ion binding]; metal-binding site 264198011926 active site 264198011927 I-site; other site 264198011928 Response regulator receiver domain; Region: Response_reg; pfam00072 264198011929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198011930 active site 264198011931 phosphorylation site [posttranslational modification] 264198011932 intermolecular recognition site; other site 264198011933 dimerization interface [polypeptide binding]; other site 264198011934 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 264198011935 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 264198011936 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 264198011937 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 264198011938 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264198011939 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198011940 dimer interface [polypeptide binding]; other site 264198011941 phosphorylation site [posttranslational modification] 264198011942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198011943 ATP binding site [chemical binding]; other site 264198011944 Mg2+ binding site [ion binding]; other site 264198011945 G-X-G motif; other site 264198011946 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 264198011947 16S rRNA methyltransferase B; Provisional; Region: PRK10901 264198011948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198011949 S-adenosylmethionine binding site [chemical binding]; other site 264198011950 Peptidase family M48; Region: Peptidase_M48; cl12018 264198011951 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 264198011952 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 264198011953 putative active site [active] 264198011954 substrate binding site [chemical binding]; other site 264198011955 putative cosubstrate binding site; other site 264198011956 catalytic site [active] 264198011957 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 264198011958 substrate binding site [chemical binding]; other site 264198011959 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 264198011960 active site 264198011961 catalytic residues [active] 264198011962 metal binding site [ion binding]; metal-binding site 264198011963 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 264198011964 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 264198011965 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 264198011966 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 264198011967 catalytic residues [active] 264198011968 DNA topoisomerase III; Validated; Region: PRK08173 264198011969 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 264198011970 active site 264198011971 putative interdomain interaction site [polypeptide binding]; other site 264198011972 putative metal-binding site [ion binding]; other site 264198011973 putative nucleotide binding site [chemical binding]; other site 264198011974 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 264198011975 domain I; other site 264198011976 DNA binding groove [nucleotide binding] 264198011977 phosphate binding site [ion binding]; other site 264198011978 domain II; other site 264198011979 domain III; other site 264198011980 nucleotide binding site [chemical binding]; other site 264198011981 catalytic site [active] 264198011982 domain IV; other site 264198011983 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 264198011984 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 264198011985 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198011986 Helix-turn-helix domains; Region: HTH; cl00088 264198011987 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198011988 putative effector binding pocket; other site 264198011989 dimerization interface [polypeptide binding]; other site 264198011990 Protein of unknown function (DUF466); Region: DUF466; cl01082 264198011991 carbon starvation protein A; Provisional; Region: PRK15015 264198011992 Carbon starvation protein CstA; Region: CstA; pfam02554 264198011993 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 264198011994 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 264198011995 Cache domain; Region: Cache_2; cl07034 264198011996 Histidine kinase; Region: HisKA_3; pfam07730 264198011997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 264198011998 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198011999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198012000 active site 264198012001 phosphorylation site [posttranslational modification] 264198012002 intermolecular recognition site; other site 264198012003 dimerization interface [polypeptide binding]; other site 264198012004 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198012005 DNA binding residues [nucleotide binding] 264198012006 dimerization interface [polypeptide binding]; other site 264198012007 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 264198012008 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 264198012009 active site 264198012010 substrate-binding site [chemical binding]; other site 264198012011 metal-binding site [ion binding] 264198012012 GTP binding site [chemical binding]; other site 264198012013 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 264198012014 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198012015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198012016 putative substrate translocation pore; other site 264198012017 MOSC domain; Region: MOSC; pfam03473 264198012018 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264198012019 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198012020 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198012021 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 264198012022 Protein of unknown function, DUF399; Region: DUF399; cl01139 264198012023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198012024 NMT1-like family; Region: NMT1_2; cl15260 264198012025 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 264198012026 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 264198012027 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 264198012028 Putative ammonia monooxygenase; Region: AmoA; pfam05145 264198012029 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 264198012030 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 264198012031 CoenzymeA binding site [chemical binding]; other site 264198012032 subunit interaction site [polypeptide binding]; other site 264198012033 PHB binding site; other site 264198012034 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 264198012035 active site 264198012036 nucleophile elbow; other site 264198012037 glutathione reductase; Validated; Region: PRK06116 264198012038 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198012039 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198012040 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 264198012041 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 264198012042 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198012043 dimer interface [polypeptide binding]; other site 264198012044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198012045 ATP binding site [chemical binding]; other site 264198012046 Mg2+ binding site [ion binding]; other site 264198012047 G-X-G motif; other site 264198012048 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 264198012049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198012050 active site 264198012051 phosphorylation site [posttranslational modification] 264198012052 intermolecular recognition site; other site 264198012053 dimerization interface [polypeptide binding]; other site 264198012054 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198012055 DNA binding site [nucleotide binding] 264198012056 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 264198012057 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198012058 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 264198012059 Helix-turn-helix domains; Region: HTH; cl00088 264198012060 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 264198012061 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 264198012062 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198012063 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198012064 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 264198012065 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 264198012066 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 264198012067 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 264198012068 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 264198012069 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198012070 Helix-turn-helix domains; Region: HTH; cl00088 264198012071 Helix-turn-helix domains; Region: HTH; cl00088 264198012072 cell density-dependent motility repressor; Provisional; Region: PRK10082 264198012073 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264198012074 dimerization interface [polypeptide binding]; other site 264198012075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198012076 NMT1-like family; Region: NMT1_2; cl15260 264198012077 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_7; cd06910 264198012078 putative active site [active] 264198012079 Zn binding site [ion binding]; other site 264198012080 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 264198012081 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 264198012082 homodimer interface [polypeptide binding]; other site 264198012083 active site 264198012084 TDP-binding site; other site 264198012085 acceptor substrate-binding pocket; other site 264198012086 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 264198012087 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264198012088 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 264198012089 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 264198012090 oligomeric interface; other site 264198012091 putative active site [active] 264198012092 homodimer interface [polypeptide binding]; other site 264198012093 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 264198012094 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 264198012095 trmE is a tRNA modification GTPase; Region: trmE; cd04164 264198012096 G1 box; other site 264198012097 GTP/Mg2+ binding site [chemical binding]; other site 264198012098 Switch I region; other site 264198012099 G2 box; other site 264198012100 Switch II region; other site 264198012101 G3 box; other site 264198012102 G4 box; other site 264198012103 G5 box; other site 264198012104 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 264198012105 CHAD domain; Region: CHAD; cl10506 264198012106 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 264198012107 CoenzymeA binding site [chemical binding]; other site 264198012108 subunit interaction site [polypeptide binding]; other site 264198012109 PHB binding site; other site 264198012110 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 264198012111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198012112 S-adenosylmethionine binding site [chemical binding]; other site 264198012113 membrane protein insertase; Provisional; Region: PRK01318 264198012114 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 264198012115 Haemolytic domain; Region: Haemolytic; cl00506 264198012116 Ribonuclease P; Region: Ribonuclease_P; cl00457 264198012117 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 264198012118 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 264198012119 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 264198012120 substrate binding site [chemical binding]; other site 264198012121 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 264198012122 substrate binding site [chemical binding]; other site 264198012123 ligand binding site [chemical binding]; other site 264198012124 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 264198012125 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 264198012126 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 264198012127 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198012128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198012129 Flavin Reductases; Region: FlaRed; cl00801 264198012130 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 264198012131 classical (c) SDRs; Region: SDR_c; cd05233 264198012132 NAD(P) binding site [chemical binding]; other site 264198012133 active site 264198012134 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198012135 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198012136 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39_likeD; cd02421 264198012137 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264198012138 TOBE domain; Region: TOBE_2; cl01440 264198012139 TOBE domain; Region: TOBE_2; cl01440 264198012140 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198012141 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 264198012142 homotrimer interaction site [polypeptide binding]; other site 264198012143 putative active site [active] 264198012144 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 264198012145 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198012146 NMT1-like family; Region: NMT1_2; cl15260 264198012147 Cytochrome c; Region: Cytochrom_C; cl11414 264198012148 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 264198012149 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 264198012150 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 264198012151 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 264198012152 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264198012153 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 264198012154 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198012155 membrane-bound complex binding site; other site 264198012156 short chain dehydrogenase; Provisional; Region: PRK12937 264198012157 classical (c) SDRs; Region: SDR_c; cd05233 264198012158 NAD(P) binding site [chemical binding]; other site 264198012159 active site 264198012160 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198012161 Helix-turn-helix domains; Region: HTH; cl00088 264198012162 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198012163 putative effector binding pocket; other site 264198012164 dimerization interface [polypeptide binding]; other site 264198012165 YCII-related domain; Region: YCII; cl00999 264198012166 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264198012167 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 264198012168 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 264198012169 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264198012170 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 264198012171 C-terminal domain interface [polypeptide binding]; other site 264198012172 GSH binding site (G-site) [chemical binding]; other site 264198012173 dimer interface [polypeptide binding]; other site 264198012174 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 264198012175 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 264198012176 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 264198012177 C-terminal domain interface [polypeptide binding]; other site 264198012178 GSH binding site (G-site) [chemical binding]; other site 264198012179 dimer interface [polypeptide binding]; other site 264198012180 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 264198012181 dimer interface [polypeptide binding]; other site 264198012182 N-terminal domain interface [polypeptide binding]; other site 264198012183 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 264198012184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198012185 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 264198012186 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 264198012187 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198012188 Helix-turn-helix domains; Region: HTH; cl00088 264198012189 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198012190 dimerization interface [polypeptide binding]; other site 264198012191 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198012192 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198012193 active site 264198012194 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 264198012195 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264198012196 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 264198012197 E3 interaction surface; other site 264198012198 lipoyl attachment site [posttranslational modification]; other site 264198012199 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198012200 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 264198012201 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 264198012202 CsbD-like; Region: CsbD; cl15799 264198012203 sensor protein ZraS; Provisional; Region: PRK10364 264198012204 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198012205 dimer interface [polypeptide binding]; other site 264198012206 phosphorylation site [posttranslational modification] 264198012207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198012208 ATP binding site [chemical binding]; other site 264198012209 Mg2+ binding site [ion binding]; other site 264198012210 G-X-G motif; other site 264198012211 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 264198012212 active site 264198012213 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 264198012214 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 264198012215 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 264198012216 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198012217 DNA-binding site [nucleotide binding]; DNA binding site 264198012218 UTRA domain; Region: UTRA; cl01230 264198012219 hypothetical protein; Validated; Region: PRK07586 264198012220 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 264198012221 PYR/PP interface [polypeptide binding]; other site 264198012222 dimer interface [polypeptide binding]; other site 264198012223 TPP binding site [chemical binding]; other site 264198012224 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 264198012225 TPP-binding site [chemical binding]; other site 264198012226 dimer interface [polypeptide binding]; other site 264198012227 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 264198012228 DUF35 OB-fold domain; Region: DUF35; pfam01796 264198012229 thiolase; Provisional; Region: PRK06158 264198012230 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 264198012231 active site 264198012232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198012233 NMT1-like family; Region: NMT1_2; cl15260 264198012234 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 264198012235 AMP-binding enzyme; Region: AMP-binding; cl15778 264198012236 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198012237 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198012238 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 264198012239 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198012240 active site 264198012241 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 264198012242 putative active site [active] 264198012243 putative substrate binding site [chemical binding]; other site 264198012244 ATP binding site [chemical binding]; other site 264198012245 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198012246 Helix-turn-helix domains; Region: HTH; cl00088 264198012247 Protein of unknown function (DUF3260); Region: DUF3260; cl11881 264198012248 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 264198012249 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264198012250 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 264198012251 DXD motif; other site 264198012252 PilZ domain; Region: PilZ; cl01260 264198012253 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 264198012254 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198012255 cellulose biosynthesis protein BcsE; Region: cellulose_bcsE; TIGR03369 264198012256 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 264198012257 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 264198012258 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264198012259 binding surface 264198012260 TPR motif; other site 264198012261 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264198012262 binding surface 264198012263 TPR motif; other site 264198012264 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 264198012265 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 264198012266 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 264198012267 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 264198012268 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 264198012269 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 264198012270 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 264198012271 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198012272 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 264198012273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198012274 NMT1-like family; Region: NMT1_2; cl15260 264198012275 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 264198012276 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198012277 DNA-binding site [nucleotide binding]; DNA binding site 264198012278 UTRA domain; Region: UTRA; cl01230 264198012279 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 264198012280 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198012281 active site 264198012282 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 264198012283 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 264198012284 FAD binding site [chemical binding]; other site 264198012285 substrate binding site [chemical binding]; other site 264198012286 catalytic base [active] 264198012287 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 264198012288 AMP-binding enzyme; Region: AMP-binding; cl15778 264198012289 AMP-binding enzyme; Region: AMP-binding; cl15778 264198012290 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198012291 NMT1-like family; Region: NMT1_2; cl15260 264198012292 Uncharacterized conserved protein [Function unknown]; Region: COG3777 264198012293 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 264198012294 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 264198012295 active site 2 [active] 264198012296 active site 1 [active] 264198012297 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 264198012298 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 264198012299 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198012300 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198012301 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198012302 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198012303 active site 264198012304 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 264198012305 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198012306 Helix-turn-helix domains; Region: HTH; cl00088 264198012307 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 264198012308 putative dimerization interface [polypeptide binding]; other site 264198012309 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198012310 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 264198012311 NAD(P) binding site [chemical binding]; other site 264198012312 active site 264198012313 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198012314 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198012315 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198012316 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198012317 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198012318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198012319 NMT1-like family; Region: NMT1_2; cl15260 264198012320 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 264198012321 AMP-binding enzyme; Region: AMP-binding; cl15778 264198012322 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198012323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198012324 NMT1-like family; Region: NMT1_2; cl15260 264198012325 enoyl-CoA hydratase; Provisional; Region: PRK06688 264198012326 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198012327 substrate binding site [chemical binding]; other site 264198012328 oxyanion hole (OAH) forming residues; other site 264198012329 trimer interface [polypeptide binding]; other site 264198012330 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198012331 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198012332 active site 264198012333 PrkA family serine protein kinase; Provisional; Region: PRK15455 264198012334 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 264198012335 Uncharacterized conserved protein [Function unknown]; Region: COG2718 264198012336 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 264198012337 SpoVR family protein; Provisional; Region: PRK11767 264198012338 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 264198012339 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198012340 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198012341 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 264198012342 active site 264198012343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198012344 NMT1-like family; Region: NMT1_2; cl15260 264198012345 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 264198012346 active site 2 [active] 264198012347 active site 1 [active] 264198012348 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198012349 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198012350 Helix-turn-helix domains; Region: HTH; cl00088 264198012351 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 264198012352 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 264198012353 dimerization interface [polypeptide binding]; other site 264198012354 substrate binding pocket [chemical binding]; other site 264198012355 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198012356 DNA binding residues [nucleotide binding] 264198012357 dimerization interface [polypeptide binding]; other site 264198012358 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264198012359 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198012360 NAD(P) binding site [chemical binding]; other site 264198012361 active site 264198012362 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 264198012363 AMP-binding enzyme; Region: AMP-binding; cl15778 264198012364 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198012365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198012366 NMT1-like family; Region: NMT1_2; cl15260 264198012367 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198012368 trimer interface [polypeptide binding]; other site 264198012369 eyelet of channel; other site 264198012370 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264198012371 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 264198012372 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 264198012373 iron-sulfur cluster [ion binding]; other site 264198012374 [2Fe-2S] cluster binding site [ion binding]; other site 264198012375 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 264198012376 hydrophobic ligand binding site; other site 264198012377 short chain dehydrogenase; Provisional; Region: PRK12939 264198012378 classical (c) SDRs; Region: SDR_c; cd05233 264198012379 NAD(P) binding site [chemical binding]; other site 264198012380 active site 264198012381 Cupin domain; Region: Cupin_2; cl09118 264198012382 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198012383 Helix-turn-helix domains; Region: HTH; cl00088 264198012384 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198012385 short chain dehydrogenase; Provisional; Region: PRK07062 264198012386 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 264198012387 putative NAD(P) binding site [chemical binding]; other site 264198012388 putative active site [active] 264198012389 hypothetical protein; Provisional; Region: PRK07064 264198012390 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 264198012391 PYR/PP interface [polypeptide binding]; other site 264198012392 dimer interface [polypeptide binding]; other site 264198012393 TPP binding site [chemical binding]; other site 264198012394 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 264198012395 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 264198012396 TPP-binding site [chemical binding]; other site 264198012397 L-aspartate dehydrogenase; Provisional; Region: PRK13303 264198012398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198012399 Domain of unknown function DUF108; Region: DUF108; pfam01958 264198012400 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198012401 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 264198012402 NAD(P) binding site [chemical binding]; other site 264198012403 catalytic residues [active] 264198012404 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 264198012405 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198012406 putative active site [active] 264198012407 putative metal binding site [ion binding]; other site 264198012408 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 264198012409 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 264198012410 FMN-binding pocket [chemical binding]; other site 264198012411 flavin binding motif; other site 264198012412 phosphate binding motif [ion binding]; other site 264198012413 beta-alpha-beta structure motif; other site 264198012414 NAD binding pocket [chemical binding]; other site 264198012415 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198012416 catalytic loop [active] 264198012417 iron binding site [ion binding]; other site 264198012418 benzoate transport; Region: 2A0115; TIGR00895 264198012419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198012420 putative substrate translocation pore; other site 264198012421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198012422 cystathionine beta-lyase; Provisional; Region: PRK09028 264198012423 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 264198012424 homodimer interface [polypeptide binding]; other site 264198012425 substrate-cofactor binding pocket; other site 264198012426 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198012427 catalytic residue [active] 264198012428 D-cysteine desulfhydrase; Validated; Region: PRK03910 264198012429 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 264198012430 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264198012431 catalytic residue [active] 264198012432 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 264198012433 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 264198012434 Walker A/P-loop; other site 264198012435 ATP binding site [chemical binding]; other site 264198012436 Q-loop/lid; other site 264198012437 ABC transporter signature motif; other site 264198012438 Walker B; other site 264198012439 D-loop; other site 264198012440 H-loop/switch region; other site 264198012441 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 264198012442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198012443 dimer interface [polypeptide binding]; other site 264198012444 conserved gate region; other site 264198012445 putative PBP binding loops; other site 264198012446 ABC-ATPase subunit interface; other site 264198012447 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264198012448 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198012449 substrate binding pocket [chemical binding]; other site 264198012450 membrane-bound complex binding site; other site 264198012451 hinge residues; other site 264198012452 Protein of unknown function (DUF3088); Region: DUF3088; pfam11287 264198012453 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 264198012454 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 264198012455 conserved cys residue [active] 264198012456 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198012457 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 264198012458 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 264198012459 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 264198012460 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264198012461 PAS fold; Region: PAS_4; pfam08448 264198012462 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 264198012463 putative active site [active] 264198012464 heme pocket [chemical binding]; other site 264198012465 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 264198012466 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198012467 Walker A motif; other site 264198012468 ATP binding site [chemical binding]; other site 264198012469 Walker B motif; other site 264198012470 arginine finger; other site 264198012471 Helix-turn-helix domains; Region: HTH; cl00088 264198012472 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 264198012473 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264198012474 Helix-turn-helix domains; Region: HTH; cl00088 264198012475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198012476 NMT1-like family; Region: NMT1_2; cl15260 264198012477 4-hydroxybenzoyl-CoA reductase, alpha subunit; Region: 4hydrxCoA_A; TIGR03194 264198012478 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 264198012479 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264198012480 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 264198012481 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 264198012482 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 264198012483 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 264198012484 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 264198012485 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 264198012486 putative hydrophobic ligand binding site [chemical binding]; other site 264198012487 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198012488 Helix-turn-helix domains; Region: HTH; cl00088 264198012489 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198012490 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198012491 NMT1-like family; Region: NMT1_2; cl15260 264198012492 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198012493 Helix-turn-helix domains; Region: HTH; cl00088 264198012494 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198012495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198012496 salicylate hydroxylase; Provisional; Region: PRK06475 264198012497 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 264198012498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198012499 active site 264198012500 phosphorylation site [posttranslational modification] 264198012501 intermolecular recognition site; other site 264198012502 dimerization interface [polypeptide binding]; other site 264198012503 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198012504 DNA binding residues [nucleotide binding] 264198012505 dimerization interface [polypeptide binding]; other site 264198012506 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 264198012507 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198012508 active site 264198012509 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 264198012510 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198012511 active site 264198012512 acyl-CoA synthetase; Provisional; Region: PRK13391 264198012513 AMP-binding enzyme; Region: AMP-binding; cl15778 264198012514 AMP-binding enzyme; Region: AMP-binding; cl15778 264198012515 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 264198012516 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198012517 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198012518 DNA binding residues [nucleotide binding] 264198012519 dimerization interface [polypeptide binding]; other site 264198012520 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 264198012521 putative FMN binding site [chemical binding]; other site 264198012522 enoyl-CoA hydratase; Provisional; Region: PRK08260 264198012523 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198012524 substrate binding site [chemical binding]; other site 264198012525 oxyanion hole (OAH) forming residues; other site 264198012526 trimer interface [polypeptide binding]; other site 264198012527 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 264198012528 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 264198012529 FMN binding site [chemical binding]; other site 264198012530 substrate binding site [chemical binding]; other site 264198012531 putative catalytic residue [active] 264198012532 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 264198012533 CoenzymeA binding site [chemical binding]; other site 264198012534 subunit interaction site [polypeptide binding]; other site 264198012535 PHB binding site; other site 264198012536 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 264198012537 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264198012538 dimer interface [polypeptide binding]; other site 264198012539 active site 264198012540 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264198012541 catalytic core [active] 264198012542 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198012543 NMT1-like family; Region: NMT1_2; cl15260 264198012544 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 264198012545 active site 264198012546 catalytic site [active] 264198012547 substrate binding site [chemical binding]; other site 264198012548 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 264198012549 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 264198012550 GIY-YIG motif/motif A; other site 264198012551 active site 264198012552 catalytic site [active] 264198012553 putative DNA binding site [nucleotide binding]; other site 264198012554 metal binding site [ion binding]; metal-binding site 264198012555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198012556 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198012557 putative substrate translocation pore; other site 264198012558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198012559 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264198012560 Helix-turn-helix domains; Region: HTH; cl00088 264198012561 transcriptional regulator RcsB; Provisional; Region: PRK10840 264198012562 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198012563 active site 264198012564 phosphorylation site [posttranslational modification] 264198012565 intermolecular recognition site; other site 264198012566 dimerization interface [polypeptide binding]; other site 264198012567 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198012568 DNA binding residues [nucleotide binding] 264198012569 dimerization interface [polypeptide binding]; other site 264198012570 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198012571 Helix-turn-helix domains; Region: HTH; cl00088 264198012572 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198012573 dimerization interface [polypeptide binding]; other site 264198012574 Helix-turn-helix domains; Region: HTH; cl00088 264198012575 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 264198012576 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 264198012577 transcriptional regulator FixK; Provisional; Region: fixK; PRK09391 264198012578 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198012579 ligand binding site [chemical binding]; other site 264198012580 flexible hinge region; other site 264198012581 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 264198012582 putative switch regulator; other site 264198012583 non-specific DNA interactions [nucleotide binding]; other site 264198012584 DNA binding site [nucleotide binding] 264198012585 sequence specific DNA binding site [nucleotide binding]; other site 264198012586 putative cAMP binding site [chemical binding]; other site 264198012587 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 264198012588 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198012589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198012590 metabolite-proton symporter; Region: 2A0106; TIGR00883 264198012591 putative substrate translocation pore; other site 264198012592 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 264198012593 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 264198012594 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 264198012595 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 264198012596 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 264198012597 ligand binding site [chemical binding]; other site 264198012598 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 264198012599 Rubredoxin; Region: Rubredoxin; pfam00301 264198012600 iron binding site [ion binding]; other site 264198012601 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 264198012602 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 264198012603 Cytochrome c; Region: Cytochrom_C; cl11414 264198012604 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 264198012605 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 264198012606 D-pathway; other site 264198012607 Low-spin heme binding site [chemical binding]; other site 264198012608 Putative water exit pathway; other site 264198012609 Binuclear center (active site) [active] 264198012610 K-pathway; other site 264198012611 Putative proton exit pathway; other site 264198012612 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865 264198012613 Subunit I/III interface [polypeptide binding]; other site 264198012614 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864 264198012615 Subunit I/III interface [polypeptide binding]; other site 264198012616 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 264198012617 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 264198012618 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198012619 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 264198012620 tetramerization interface [polypeptide binding]; other site 264198012621 NAD(P) binding site [chemical binding]; other site 264198012622 catalytic residues [active] 264198012623 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 264198012624 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 264198012625 active site 264198012626 nucleophile elbow; other site 264198012627 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 264198012628 Double zinc ribbon; Region: DZR; pfam12773 264198012629 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 264198012630 cyclase homology domain; Region: CHD; cd07302 264198012631 nucleotidyl binding site; other site 264198012632 metal binding site [ion binding]; metal-binding site 264198012633 dimer interface [polypeptide binding]; other site 264198012634 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 264198012635 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198012636 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 264198012637 MatE; Region: MatE; cl10513 264198012638 MatE; Region: MatE; cl10513 264198012639 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 264198012640 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 264198012641 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 264198012642 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 264198012643 Response regulator receiver domain; Region: Response_reg; pfam00072 264198012644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198012645 active site 264198012646 phosphorylation site [posttranslational modification] 264198012647 intermolecular recognition site; other site 264198012648 dimerization interface [polypeptide binding]; other site 264198012649 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198012650 metal binding site [ion binding]; metal-binding site 264198012651 active site 264198012652 I-site; other site 264198012653 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 264198012654 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198012655 active site 264198012656 phosphorylation site [posttranslational modification] 264198012657 intermolecular recognition site; other site 264198012658 dimerization interface [polypeptide binding]; other site 264198012659 CheB methylesterase; Region: CheB_methylest; pfam01339 264198012660 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 264198012661 putative binding surface; other site 264198012662 active site 264198012663 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 264198012664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198012665 ATP binding site [chemical binding]; other site 264198012666 Mg2+ binding site [ion binding]; other site 264198012667 G-X-G motif; other site 264198012668 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 264198012669 Response regulator receiver domain; Region: Response_reg; pfam00072 264198012670 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198012671 active site 264198012672 phosphorylation site [posttranslational modification] 264198012673 intermolecular recognition site; other site 264198012674 dimerization interface [polypeptide binding]; other site 264198012675 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 264198012676 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 264198012677 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 264198012678 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 264198012679 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264198012680 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 264198012681 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264198012682 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198012683 dimer interface [polypeptide binding]; other site 264198012684 putative CheW interface [polypeptide binding]; other site 264198012685 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198012686 metal binding site [ion binding]; metal-binding site 264198012687 active site 264198012688 I-site; other site 264198012689 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264198012690 FecR protein; Region: FecR; pfam04773 264198012691 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 264198012692 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336 264198012693 putative ligand binding site [chemical binding]; other site 264198012694 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264198012695 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 264198012696 Walker A/P-loop; other site 264198012697 ATP binding site [chemical binding]; other site 264198012698 Q-loop/lid; other site 264198012699 ABC transporter signature motif; other site 264198012700 Walker B; other site 264198012701 D-loop; other site 264198012702 H-loop/switch region; other site 264198012703 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198012704 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 264198012705 Walker A/P-loop; other site 264198012706 ATP binding site [chemical binding]; other site 264198012707 Q-loop/lid; other site 264198012708 ABC transporter signature motif; other site 264198012709 Walker B; other site 264198012710 D-loop; other site 264198012711 H-loop/switch region; other site 264198012712 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198012713 TM-ABC transporter signature motif; other site 264198012714 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198012715 TM-ABC transporter signature motif; other site 264198012716 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198012717 Helix-turn-helix domains; Region: HTH; cl00088 264198012718 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198012719 short chain dehydrogenase; Provisional; Region: PRK06138 264198012720 classical (c) SDRs; Region: SDR_c; cd05233 264198012721 NAD(P) binding site [chemical binding]; other site 264198012722 active site 264198012723 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198012724 NMT1-like family; Region: NMT1_2; cl15260 264198012725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198012726 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198012727 putative substrate translocation pore; other site 264198012728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198012729 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 264198012730 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198012731 dimer interface [polypeptide binding]; other site 264198012732 phosphorylation site [posttranslational modification] 264198012733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198012734 ATP binding site [chemical binding]; other site 264198012735 Mg2+ binding site [ion binding]; other site 264198012736 G-X-G motif; other site 264198012737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198012738 active site 264198012739 phosphorylation site [posttranslational modification] 264198012740 intermolecular recognition site; other site 264198012741 dimerization interface [polypeptide binding]; other site 264198012742 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198012743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198012744 active site 264198012745 phosphorylation site [posttranslational modification] 264198012746 intermolecular recognition site; other site 264198012747 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198012748 DNA binding residues [nucleotide binding] 264198012749 dimerization interface [polypeptide binding]; other site 264198012750 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 264198012751 Sensors of blue-light using FAD; Region: BLUF; cl04855 264198012752 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 264198012753 GTP cyclohydrolase I; Provisional; Region: PLN03044 264198012754 active site 264198012755 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 264198012756 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 264198012757 transmembrane helices; other site 264198012758 Transglycosylase; Region: Transgly; cl07896 264198012759 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 264198012760 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 264198012761 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198012762 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 264198012763 Protein of unknown function (DUF779); Region: DUF779; cl01432 264198012764 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 264198012765 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 264198012766 NAD binding site [chemical binding]; other site 264198012767 substrate binding site [chemical binding]; other site 264198012768 catalytic Zn binding site [ion binding]; other site 264198012769 tetramer interface [polypeptide binding]; other site 264198012770 structural Zn binding site [ion binding]; other site 264198012771 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 264198012772 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198012773 NAD(P) binding site [chemical binding]; other site 264198012774 catalytic residues [active] 264198012775 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 264198012776 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 264198012777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198012778 IucA / IucC family; Region: IucA_IucC; pfam04183 264198012779 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 264198012780 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 264198012781 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198012782 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 264198012783 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 264198012784 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 264198012785 dimer interface [polypeptide binding]; other site 264198012786 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198012787 catalytic residue [active] 264198012788 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 264198012789 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 264198012790 dimer interface [polypeptide binding]; other site 264198012791 active site 264198012792 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264198012793 catalytic residues [active] 264198012794 substrate binding site [chemical binding]; other site 264198012795 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 264198012796 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264198012797 N-terminal plug; other site 264198012798 ligand-binding site [chemical binding]; other site 264198012799 ParB-like nuclease domain; Region: ParBc; cl02129 264198012800 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 264198012801 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 264198012802 putative active site [active] 264198012803 catalytic residue [active] 264198012804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198012805 D-galactonate transporter; Region: 2A0114; TIGR00893 264198012806 putative substrate translocation pore; other site 264198012807 galactarate dehydratase; Region: galactar-dH20; TIGR03248 264198012808 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 264198012809 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 264198012810 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198012811 classical (c) SDRs; Region: SDR_c; cd05233 264198012812 NAD(P) binding site [chemical binding]; other site 264198012813 active site 264198012814 LysR family transcriptional regulator; Provisional; Region: PRK14997 264198012815 Helix-turn-helix domains; Region: HTH; cl00088 264198012816 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198012817 putative effector binding pocket; other site 264198012818 dimerization interface [polypeptide binding]; other site 264198012819 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 264198012820 Helix-turn-helix domains; Region: HTH; cl00088 264198012821 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198012822 dimerization interface [polypeptide binding]; other site 264198012823 LysE type translocator; Region: LysE; cl00565 264198012824 Helix-turn-helix domains; Region: HTH; cl00088 264198012825 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 264198012826 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 264198012827 putative active site [active] 264198012828 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 264198012829 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 264198012830 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 264198012831 Walker A/P-loop; other site 264198012832 ATP binding site [chemical binding]; other site 264198012833 Q-loop/lid; other site 264198012834 ABC transporter signature motif; other site 264198012835 Walker B; other site 264198012836 D-loop; other site 264198012837 H-loop/switch region; other site 264198012838 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 264198012839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198012840 dimer interface [polypeptide binding]; other site 264198012841 conserved gate region; other site 264198012842 putative PBP binding loops; other site 264198012843 ABC-ATPase subunit interface; other site 264198012844 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 264198012845 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198012846 substrate binding pocket [chemical binding]; other site 264198012847 membrane-bound complex binding site; other site 264198012848 hinge residues; other site 264198012849 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 264198012850 Helix-turn-helix domains; Region: HTH; cl00088 264198012851 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198012852 dimerization interface [polypeptide binding]; other site 264198012853 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198012854 Helix-turn-helix domains; Region: HTH; cl00088 264198012855 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 264198012856 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198012857 CoA-ligase; Region: Ligase_CoA; cl02894 264198012858 ATP-grasp domain; Region: ATP-grasp_4; cl03087 264198012859 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198012860 NMT1-like family; Region: NMT1_2; cl15260 264198012861 Uncharacterized conserved protein [Function unknown]; Region: COG5361 264198012862 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 264198012863 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 264198012864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198012865 NMT1-like family; Region: NMT1_2; cl15260 264198012866 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264198012867 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 264198012868 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198012869 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198012870 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198012871 substrate binding site [chemical binding]; other site 264198012872 oxyanion hole (OAH) forming residues; other site 264198012873 trimer interface [polypeptide binding]; other site 264198012874 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198012875 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 264198012876 active site 264198012877 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 264198012878 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198012879 active site 264198012880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198012881 NMT1-like family; Region: NMT1_2; cl15260 264198012882 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198012883 eyelet of channel; other site 264198012884 trimer interface [polypeptide binding]; other site 264198012885 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 264198012886 dimer interface [polypeptide binding]; other site 264198012887 NADP binding site [chemical binding]; other site 264198012888 catalytic residues [active] 264198012889 Transcriptional regulators [Transcription]; Region: FadR; COG2186 264198012890 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198012891 DNA-binding site [nucleotide binding]; DNA binding site 264198012892 FCD domain; Region: FCD; cl11656 264198012893 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 264198012894 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 264198012895 active site 264198012896 tetramer interface [polypeptide binding]; other site 264198012897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198012898 NMT1-like family; Region: NMT1_2; cl15260 264198012899 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 264198012900 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 264198012901 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264198012902 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264198012903 catalytic residue [active] 264198012904 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 264198012905 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198012906 DNA-binding site [nucleotide binding]; DNA binding site 264198012907 FCD domain; Region: FCD; cl11656 264198012908 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 264198012909 Sulfatase; Region: Sulfatase; cl10460 264198012910 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198012911 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 264198012912 NAD(P) binding site [chemical binding]; other site 264198012913 catalytic residues [active] 264198012914 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 264198012915 Helix-turn-helix domains; Region: HTH; cl00088 264198012916 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 264198012917 Fimbrial protein; Region: Fimbrial; cl01416 264198012918 glutamate dehydrogenase; Provisional; Region: PRK09414 264198012919 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 264198012920 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 264198012921 NAD(P) binding site [chemical binding]; other site 264198012922 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198012923 dimer interface [polypeptide binding]; other site 264198012924 putative CheW interface [polypeptide binding]; other site 264198012925 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 264198012926 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198012927 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 264198012928 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198012929 Walker A motif; other site 264198012930 ATP binding site [chemical binding]; other site 264198012931 Walker B motif; other site 264198012932 arginine finger; other site 264198012933 Citrate transporter; Region: CitMHS; pfam03600 264198012934 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 264198012935 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 264198012936 NAD binding site [chemical binding]; other site 264198012937 homotetramer interface [polypeptide binding]; other site 264198012938 homodimer interface [polypeptide binding]; other site 264198012939 substrate binding site [chemical binding]; other site 264198012940 active site 264198012941 Phasin protein; Region: Phasin_2; cl11491 264198012942 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264198012943 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264198012944 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264198012945 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198012946 dimer interface [polypeptide binding]; other site 264198012947 putative CheW interface [polypeptide binding]; other site 264198012948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 264198012949 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 264198012950 substrate binding site [chemical binding]; other site 264198012951 PaaX-like protein; Region: PaaX; pfam07848 264198012952 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 264198012953 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 264198012954 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 264198012955 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 264198012956 Phenylacetic acid degradation B; Region: PaaB; cl01371 264198012957 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 264198012958 Domain of unknown function DUF59; Region: DUF59; cl00941 264198012959 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 264198012960 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 264198012961 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 264198012962 FAD binding pocket [chemical binding]; other site 264198012963 FAD binding motif [chemical binding]; other site 264198012964 phosphate binding motif [ion binding]; other site 264198012965 beta-alpha-beta structure motif; other site 264198012966 NAD(p) ribose binding residues [chemical binding]; other site 264198012967 NAD binding pocket [chemical binding]; other site 264198012968 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 264198012969 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198012970 catalytic loop [active] 264198012971 iron binding site [ion binding]; other site 264198012972 Phenylacetic acid degradation proteins PaaZ (Escherichia coli) and PaaN (Pseudomonas putida)-like; Region: ALDH_PAD-PaaZ; cd07127 264198012973 NADP binding site [chemical binding]; other site 264198012974 catalytic residues [active] 264198012975 AMP-binding enzyme; Region: AMP-binding; cl15778 264198012976 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 264198012977 Protein of unknown function, DUF485; Region: DUF485; cl01231 264198012978 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 264198012979 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 264198012980 Na binding site [ion binding]; other site 264198012981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198012982 NMT1-like family; Region: NMT1_2; cl15260 264198012983 thymidine phosphorylase; Provisional; Region: PRK04350 264198012984 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 264198012985 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 264198012986 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264198012987 Helix-turn-helix domains; Region: HTH; cl00088 264198012988 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 264198012989 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 264198012990 dimerization interface [polypeptide binding]; other site 264198012991 active site 264198012992 elongation factor G; Reviewed; Region: PRK13351 264198012993 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 264198012994 G1 box; other site 264198012995 putative GEF interaction site [polypeptide binding]; other site 264198012996 GTP/Mg2+ binding site [chemical binding]; other site 264198012997 Switch I region; other site 264198012998 G2 box; other site 264198012999 G3 box; other site 264198013000 Switch II region; other site 264198013001 G4 box; other site 264198013002 G5 box; other site 264198013003 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 264198013004 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 264198013005 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 264198013006 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198013007 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 264198013008 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 264198013009 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 264198013010 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198013011 DNA-binding site [nucleotide binding]; DNA binding site 264198013012 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198013013 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198013014 homodimer interface [polypeptide binding]; other site 264198013015 catalytic residue [active] 264198013016 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 264198013017 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 264198013018 Helix-turn-helix domains; Region: HTH; cl00088 264198013019 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198013020 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 264198013021 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 264198013022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198013023 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 264198013024 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 264198013025 metal ion-dependent adhesion site (MIDAS); other site 264198013026 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198013027 catalytic loop [active] 264198013028 iron binding site [ion binding]; other site 264198013029 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198013030 catalytic loop [active] 264198013031 iron binding site [ion binding]; other site 264198013032 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 264198013033 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198013034 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 264198013035 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 264198013036 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198013037 NAD(P) binding site [chemical binding]; other site 264198013038 catalytic residues [active] 264198013039 Domain of unknown function (DUF336); Region: DUF336; cl01249 264198013040 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 264198013041 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198013042 catalytic loop [active] 264198013043 iron binding site [ion binding]; other site 264198013044 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 264198013045 FAD binding pocket [chemical binding]; other site 264198013046 FAD binding motif [chemical binding]; other site 264198013047 phosphate binding motif [ion binding]; other site 264198013048 beta-alpha-beta structure motif; other site 264198013049 NAD binding pocket [chemical binding]; other site 264198013050 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198013051 DNA-binding site [nucleotide binding]; DNA binding site 264198013052 FCD domain; Region: FCD; cl11656 264198013053 amidase; Provisional; Region: PRK06170 264198013054 Amidase; Region: Amidase; cl11426 264198013055 benzoate transport; Region: 2A0115; TIGR00895 264198013056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198013057 putative substrate translocation pore; other site 264198013058 autotransport protein MisL; Provisional; Region: PRK15313 264198013059 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 264198013060 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 264198013061 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 264198013062 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 264198013063 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 264198013064 sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525 264198013065 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 264198013066 PYR/PP interface [polypeptide binding]; other site 264198013067 dimer interface [polypeptide binding]; other site 264198013068 TPP binding site [chemical binding]; other site 264198013069 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 264198013070 Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of proteins similar to Alcaligenes defragrans sulfoacetaldehyde acetyltransferase (Xsc). Xsc plays a key role in the degradation of taurine, catalyzing the...; Region: TPP_Xsc_like; cd02013 264198013071 TPP-binding site; other site 264198013072 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264198013073 Helix-turn-helix domains; Region: HTH; cl00088 264198013074 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 264198013075 inter-subunit interface; other site 264198013076 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 264198013077 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 264198013078 iron-sulfur cluster [ion binding]; other site 264198013079 [2Fe-2S] cluster binding site [ion binding]; other site 264198013080 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 264198013081 putative alpha subunit interface [polypeptide binding]; other site 264198013082 putative active site [active] 264198013083 putative substrate binding site [chemical binding]; other site 264198013084 Fe binding site [ion binding]; other site 264198013085 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 264198013086 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198013087 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 264198013088 [2Fe-2S] cluster binding site [ion binding]; other site 264198013089 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198013090 TM-ABC transporter signature motif; other site 264198013091 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198013092 TM-ABC transporter signature motif; other site 264198013093 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264198013094 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 264198013095 Walker A/P-loop; other site 264198013096 ATP binding site [chemical binding]; other site 264198013097 Q-loop/lid; other site 264198013098 ABC transporter signature motif; other site 264198013099 Walker B; other site 264198013100 D-loop; other site 264198013101 H-loop/switch region; other site 264198013102 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198013103 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 264198013104 Walker A/P-loop; other site 264198013105 ATP binding site [chemical binding]; other site 264198013106 Q-loop/lid; other site 264198013107 ABC transporter signature motif; other site 264198013108 Walker B; other site 264198013109 D-loop; other site 264198013110 H-loop/switch region; other site 264198013111 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198013112 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 264198013113 putative ligand binding site [chemical binding]; other site 264198013114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198013115 putative substrate translocation pore; other site 264198013116 metabolite-proton symporter; Region: 2A0106; TIGR00883 264198013117 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198013118 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 264198013119 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264198013120 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 264198013121 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 264198013122 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015 264198013123 Isochorismatase family; Region: Isochorismatase; pfam00857 264198013124 catalytic triad [active] 264198013125 substrate binding site [chemical binding]; other site 264198013126 domain interfaces; other site 264198013127 conserved cis-peptide bond; other site 264198013128 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 264198013129 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 264198013130 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264198013131 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 264198013132 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 264198013133 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198013134 catalytic loop [active] 264198013135 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 264198013136 iron binding site [ion binding]; other site 264198013137 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 264198013138 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 264198013139 putative hydrophobic ligand binding site [chemical binding]; other site 264198013140 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 264198013141 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 264198013142 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264198013143 DNA binding residues [nucleotide binding] 264198013144 Uncharacterized conserved protein [Function unknown]; Region: COG3391 264198013145 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 264198013146 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 264198013147 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 264198013148 Domain of unknown function (DUF305); Region: DUF305; cl15795 264198013149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198013150 NMT1-like family; Region: NMT1_2; cl15260 264198013151 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198013152 NMT1-like family; Region: NMT1_2; cl15260 264198013153 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 264198013154 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198013155 DNA-binding site [nucleotide binding]; DNA binding site 264198013156 UTRA domain; Region: UTRA; cl01230 264198013157 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198013158 active site 264198013159 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 264198013160 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264198013161 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198013162 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198013163 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 264198013164 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 264198013165 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 264198013166 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 264198013167 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 264198013168 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264198013169 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 264198013170 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264198013171 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264198013172 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198013173 dimer interface [polypeptide binding]; other site 264198013174 putative CheW interface [polypeptide binding]; other site 264198013175 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 264198013176 Protein of unknown function (DUF2880); Region: DUF2880; pfam11082 264198013177 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 264198013178 Entericidin EcnA/B family; Region: Entericidin; cl02322 264198013179 EamA-like transporter family; Region: EamA; cl01037 264198013180 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 264198013181 homotrimer interaction site [polypeptide binding]; other site 264198013182 putative active site [active] 264198013183 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198013184 NMT1-like family; Region: NMT1_2; cl15260 264198013185 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 264198013186 active sites [active] 264198013187 argininosuccinate lyase; Provisional; Region: PRK00855 264198013188 tetramer interface [polypeptide binding]; other site 264198013189 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 264198013190 Helix-turn-helix domains; Region: HTH; cl00088 264198013191 The C-terminal substrate-domain of LysR-type transcriptional regulator, NocR, involved in the catabolism of nopaline, contains the type 2 periplasmic binding fold; Region: PBP2_NocR; cd08458 264198013192 putative dimerization interface [polypeptide binding]; other site 264198013193 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 264198013194 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198013195 LysR family transcriptional regulator; Provisional; Region: PRK14997 264198013196 Helix-turn-helix domains; Region: HTH; cl00088 264198013197 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198013198 putative effector binding pocket; other site 264198013199 dimerization interface [polypeptide binding]; other site 264198013200 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198013201 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198013202 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198013203 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198013204 active site 264198013205 choline dehydrogenase; Validated; Region: PRK02106 264198013206 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198013207 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 264198013208 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 264198013209 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264198013210 SCP-2 sterol transfer family; Region: SCP2; cl01225 264198013211 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 264198013212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198013213 CoA-ligase; Region: Ligase_CoA; cl02894 264198013214 ATP-grasp domain; Region: ATP-grasp_4; cl03087 264198013215 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 264198013216 DUF35 OB-fold domain; Region: DUF35; pfam01796 264198013217 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 264198013218 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 264198013219 active site 264198013220 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 264198013221 Winged helix-turn helix; Region: HTH_29; pfam13551 264198013222 Helix-turn-helix domains; Region: HTH; cl00088 264198013223 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 264198013224 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198013225 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198013226 DNA binding residues [nucleotide binding] 264198013227 D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734 264198013228 AMP-binding enzyme; Region: AMP-binding; cl15778 264198013229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198013230 short chain dehydrogenase; Provisional; Region: PRK07060 264198013231 NAD(P) binding site [chemical binding]; other site 264198013232 active site 264198013233 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 264198013234 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 264198013235 FAD binding site [chemical binding]; other site 264198013236 substrate binding site [chemical binding]; other site 264198013237 catalytic base [active] 264198013238 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 264198013239 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198013240 active site 264198013241 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 264198013242 putative active site [active] 264198013243 putative catalytic site [active] 264198013244 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198013245 classical (c) SDRs; Region: SDR_c; cd05233 264198013246 NAD(P) binding site [chemical binding]; other site 264198013247 active site 264198013248 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 264198013249 classical (c) SDRs; Region: SDR_c; cd05233 264198013250 NAD(P) binding site [chemical binding]; other site 264198013251 active site 264198013252 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 264198013253 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 264198013254 NADP binding site [chemical binding]; other site 264198013255 dimer interface [polypeptide binding]; other site 264198013256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198013257 NMT1-like family; Region: NMT1_2; cl15260 264198013258 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 264198013259 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198013260 Ligand Binding Site [chemical binding]; other site 264198013261 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 264198013262 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 264198013263 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198013264 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198013265 DNA binding residues [nucleotide binding] 264198013266 dimerization interface [polypeptide binding]; other site 264198013267 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 264198013268 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 264198013269 phosphate binding site [ion binding]; other site 264198013270 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198013271 Helix-turn-helix domain; Region: HTH_18; pfam12833 264198013272 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198013273 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 264198013274 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 264198013275 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198013276 classical (c) SDRs; Region: SDR_c; cd05233 264198013277 NAD(P) binding site [chemical binding]; other site 264198013278 active site 264198013279 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198013280 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198013281 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198013282 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 264198013283 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 264198013284 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198013285 NAD(P) binding site [chemical binding]; other site 264198013286 active site 264198013287 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 264198013288 Prostaglandin dehydrogenases; Region: PGDH; cd05288 264198013289 NAD(P) binding site [chemical binding]; other site 264198013290 substrate binding site [chemical binding]; other site 264198013291 dimer interface [polypeptide binding]; other site 264198013292 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 264198013293 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 264198013294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198013295 NMT1-like family; Region: NMT1_2; cl15260 264198013296 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198013297 trimer interface [polypeptide binding]; other site 264198013298 eyelet of channel; other site 264198013299 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 264198013300 extended (e) SDRs; Region: SDR_e; cd08946 264198013301 NAD(P) binding site [chemical binding]; other site 264198013302 active site 264198013303 substrate binding site [chemical binding]; other site 264198013304 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 264198013305 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 264198013306 FAD binding site [chemical binding]; other site 264198013307 substrate binding site [chemical binding]; other site 264198013308 catalytic base [active] 264198013309 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 264198013310 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198013311 NAD binding site [chemical binding]; other site 264198013312 catalytic residues [active] 264198013313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198013314 NMT1-like family; Region: NMT1_2; cl15260 264198013315 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198013316 trimer interface [polypeptide binding]; other site 264198013317 eyelet of channel; other site 264198013318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198013319 NMT1-like family; Region: NMT1_2; cl15260 264198013320 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198013321 Phasin protein; Region: Phasin_2; cl11491 264198013322 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 264198013323 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 264198013324 NAD(P) binding site [chemical binding]; other site 264198013325 homotetramer interface [polypeptide binding]; other site 264198013326 homodimer interface [polypeptide binding]; other site 264198013327 active site 264198013328 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198013329 Helix-turn-helix domains; Region: HTH; cl00088 264198013330 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198013331 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 264198013332 active site 264198013333 oxalacetate binding site [chemical binding]; other site 264198013334 citrylCoA binding site [chemical binding]; other site 264198013335 coenzyme A binding site [chemical binding]; other site 264198013336 catalytic triad [active] 264198013337 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 264198013338 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198013339 CoA-ligase; Region: Ligase_CoA; cl02894 264198013340 ATP-grasp domain; Region: ATP-grasp_4; cl03087 264198013341 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 264198013342 active site 2 [active] 264198013343 active site 1 [active] 264198013344 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198013345 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198013346 active site 264198013347 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198013348 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198013349 NAD(P) binding site [chemical binding]; other site 264198013350 active site 264198013351 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198013352 Helix-turn-helix domains; Region: HTH; cl00088 264198013353 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198013354 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198013355 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 264198013356 substrate binding site [chemical binding]; other site 264198013357 oxyanion hole (OAH) forming residues; other site 264198013358 trimer interface [polypeptide binding]; other site 264198013359 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198013360 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 264198013361 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 264198013362 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198013363 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198013364 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198013365 NMT1-like family; Region: NMT1_2; cl15260 264198013366 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198013367 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 264198013368 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 264198013369 NADP binding site [chemical binding]; other site 264198013370 dimer interface [polypeptide binding]; other site 264198013371 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198013372 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198013373 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198013374 Helix-turn-helix domains; Region: HTH; cl00088 264198013375 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198013376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198013377 NMT1-like family; Region: NMT1_2; cl15260 264198013378 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198013379 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198013380 active site 264198013381 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 264198013382 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198013383 CoA-ligase; Region: Ligase_CoA; cl02894 264198013384 ATP-grasp domain; Region: ATP-grasp_4; cl03087 264198013385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198013386 NMT1-like family; Region: NMT1_2; cl15260 264198013387 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 264198013388 DUF35 OB-fold domain; Region: DUF35; pfam01796 264198013389 thiolase; Provisional; Region: PRK06158 264198013390 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 264198013391 active site 264198013392 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198013393 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 264198013394 putative ligand binding site [chemical binding]; other site 264198013395 Putative cyclase; Region: Cyclase; cl00814 264198013396 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198013397 Helix-turn-helix domains; Region: HTH; cl00088 264198013398 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 264198013399 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198013400 Walker A motif; other site 264198013401 ATP binding site [chemical binding]; other site 264198013402 Walker B motif; other site 264198013403 arginine finger; other site 264198013404 Helix-turn-helix domains; Region: HTH; cl00088 264198013405 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 264198013406 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 264198013407 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 264198013408 pyruvate carboxylase; Reviewed; Region: PRK12999 264198013409 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264198013410 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 264198013411 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264198013412 carboxyltransferase (CT) interaction site; other site 264198013413 biotinylation site [posttranslational modification]; other site 264198013414 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 264198013415 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 264198013416 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 264198013417 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198013418 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198013419 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198013420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198013421 NMT1-like family; Region: NMT1_2; cl15260 264198013422 ATP-dependent DNA ligase; Validated; Region: PRK09247 264198013423 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 264198013424 active site 264198013425 DNA binding site [nucleotide binding] 264198013426 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 264198013427 DNA binding site [nucleotide binding] 264198013428 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 264198013429 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264198013430 Helix-turn-helix domains; Region: HTH; cl00088 264198013431 Uncharacterized conserved protein [Function unknown]; Region: COG5361 264198013432 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 264198013433 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 264198013434 NMT1-like family; Region: NMT1_2; cl15260 264198013435 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 264198013436 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 264198013437 transmembrane helices; other site 264198013438 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198013439 Helix-turn-helix domain; Region: HTH_18; pfam12833 264198013440 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 264198013441 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 264198013442 hypothetical protein; Provisional; Region: PRK09040 264198013443 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264198013444 ligand binding site [chemical binding]; other site 264198013445 Domain of unknown function (DUF802); Region: DUF802; pfam05650 264198013446 Protein of unknown function (DUF3348); Region: DUF3348; pfam11828 264198013447 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 264198013448 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 264198013449 catalytic residues [active] 264198013450 osmolarity response regulator; Provisional; Region: ompR; PRK09468 264198013451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198013452 active site 264198013453 phosphorylation site [posttranslational modification] 264198013454 intermolecular recognition site; other site 264198013455 dimerization interface [polypeptide binding]; other site 264198013456 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198013457 DNA binding site [nucleotide binding] 264198013458 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 264198013459 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264198013460 dimerization interface [polypeptide binding]; other site 264198013461 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 264198013462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198013463 ATP binding site [chemical binding]; other site 264198013464 Mg2+ binding site [ion binding]; other site 264198013465 G-X-G motif; other site 264198013466 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 264198013467 catalytic residues [active] 264198013468 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 264198013469 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 264198013470 putative NAD(P) binding site [chemical binding]; other site 264198013471 dimer interface [polypeptide binding]; other site 264198013472 GYD domain; Region: GYD; cl01743 264198013473 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264198013474 Helix-turn-helix domains; Region: HTH; cl00088 264198013475 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 264198013476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198013477 NAD(P) binding site [chemical binding]; other site 264198013478 active site 264198013479 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198013480 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 264198013481 substrate binding site [chemical binding]; other site 264198013482 oxyanion hole (OAH) forming residues; other site 264198013483 trimer interface [polypeptide binding]; other site 264198013484 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 264198013485 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198013486 active site 264198013487 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 264198013488 AMP-binding enzyme; Region: AMP-binding; cl15778 264198013489 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 264198013490 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264198013491 Helix-turn-helix domains; Region: HTH; cl00088 264198013492 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 264198013493 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 264198013494 Cupin domain; Region: Cupin_2; cl09118 264198013495 fumarylacetoacetase; Region: PLN02856 264198013496 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 264198013497 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 264198013498 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 264198013499 putative active site 1 [active] 264198013500 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 264198013501 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 264198013502 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 264198013503 dimer interface [polypeptide binding]; other site 264198013504 active site 264198013505 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 264198013506 Predicted exporter [General function prediction only]; Region: COG4258 264198013507 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 264198013508 putative acyl-acceptor binding pocket; other site 264198013509 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 264198013510 AMP-binding enzyme; Region: AMP-binding; cl15778 264198013511 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 264198013512 active site 2 [active] 264198013513 dimer interface [polypeptide binding]; other site 264198013514 active site 1 [active] 264198013515 Predicted membrane protein [Function unknown]; Region: COG4648 264198013516 Phosphopantetheine attachment site; Region: PP-binding; cl09936 264198013517 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198013518 NAD(P) binding site [chemical binding]; other site 264198013519 active site 264198013520 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 264198013521 Ligand binding site; other site 264198013522 Putative Catalytic site; other site 264198013523 DXD motif; other site 264198013524 Cupin domain; Region: Cupin_2; cl09118 264198013525 benzoate transport; Region: 2A0115; TIGR00895 264198013526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198013527 putative substrate translocation pore; other site 264198013528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198013529 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 264198013530 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198013531 DNA-binding site [nucleotide binding]; DNA binding site 264198013532 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198013533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198013534 homodimer interface [polypeptide binding]; other site 264198013535 catalytic residue [active] 264198013536 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 264198013537 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 264198013538 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 264198013539 Peptidase M15; Region: Peptidase_M15_3; cl01194 264198013540 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 264198013541 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 264198013542 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 264198013543 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 264198013544 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198013545 NAD(P) binding pocket [chemical binding]; other site 264198013546 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264198013547 non-specific DNA binding site [nucleotide binding]; other site 264198013548 salt bridge; other site 264198013549 sequence-specific DNA binding site [nucleotide binding]; other site 264198013550 HipA N-terminal domain; Region: Couple_hipA; cl11853 264198013551 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 264198013552 HipA-like N-terminal domain; Region: HipA_N; pfam07805 264198013553 HipA-like C-terminal domain; Region: HipA_C; pfam07804 264198013554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198013555 NMT1-like family; Region: NMT1_2; cl15260 264198013556 Dehydratase family; Region: ILVD_EDD; cl00340 264198013557 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198013558 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 264198013559 DNA-binding site [nucleotide binding]; DNA binding site 264198013560 FCD domain; Region: FCD; cl11656 264198013561 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 264198013562 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 264198013563 conserved cys residue [active] 264198013564 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198013565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198013566 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198013567 putative substrate translocation pore; other site 264198013568 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 264198013569 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198013570 Helix-turn-helix domains; Region: HTH; cl00088 264198013571 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 264198013572 putative dimerization interface [polypeptide binding]; other site 264198013573 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198013574 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130 264198013575 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 264198013576 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 264198013577 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 264198013578 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 264198013579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198013580 active site 264198013581 phosphorylation site [posttranslational modification] 264198013582 intermolecular recognition site; other site 264198013583 dimerization interface [polypeptide binding]; other site 264198013584 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198013585 DNA binding site [nucleotide binding] 264198013586 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264198013587 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198013588 dimer interface [polypeptide binding]; other site 264198013589 phosphorylation site [posttranslational modification] 264198013590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198013591 ATP binding site [chemical binding]; other site 264198013592 Mg2+ binding site [ion binding]; other site 264198013593 G-X-G motif; other site 264198013594 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 264198013595 dimer interface [polypeptide binding]; other site 264198013596 Helix-turn-helix domains; Region: HTH; cl00088 264198013597 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198013598 dimerization interface [polypeptide binding]; other site 264198013599 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 264198013600 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 264198013601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198013602 NMT1-like family; Region: NMT1_2; cl15260 264198013603 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 264198013604 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 264198013605 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198013606 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 264198013607 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 264198013608 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 264198013609 metal-binding site [ion binding] 264198013610 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264198013611 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264198013612 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 264198013613 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 264198013614 NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908 264198013615 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 264198013616 NAD binding site [chemical binding]; other site 264198013617 substrate binding site [chemical binding]; other site 264198013618 active site 264198013619 putative formyltransferase; Provisional; Region: PRK06988 264198013620 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 264198013621 active site 264198013622 substrate binding site [chemical binding]; other site 264198013623 cosubstrate binding site; other site 264198013624 catalytic site [active] 264198013625 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 264198013626 active site 264198013627 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 264198013628 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 264198013629 Ligand binding site; other site 264198013630 Putative Catalytic site; other site 264198013631 DXD motif; other site 264198013632 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 264198013633 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 264198013634 inhibitor-cofactor binding pocket; inhibition site 264198013635 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198013636 catalytic residue [active] 264198013637 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 264198013638 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 264198013639 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 264198013640 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 264198013641 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 264198013642 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264198013643 substrate binding pocket [chemical binding]; other site 264198013644 membrane-bound complex binding site; other site 264198013645 hinge residues; other site 264198013646 OpgC protein; Region: OpgC_C; cl00792 264198013647 hypothetical protein; Validated; Region: PRK07198 264198013648 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 264198013649 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 264198013650 dimerization interface [polypeptide binding]; other site 264198013651 active site 264198013652 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 264198013653 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264198013654 active site 264198013655 Helix-turn-helix domains; Region: HTH; cl00088 264198013656 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 264198013657 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 264198013658 putative ligand binding site [chemical binding]; other site 264198013659 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 264198013660 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 264198013661 Walker A/P-loop; other site 264198013662 ATP binding site [chemical binding]; other site 264198013663 Q-loop/lid; other site 264198013664 ABC transporter signature motif; other site 264198013665 Walker B; other site 264198013666 D-loop; other site 264198013667 H-loop/switch region; other site 264198013668 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 264198013669 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 264198013670 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 264198013671 TM-ABC transporter signature motif; other site 264198013672 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 264198013673 TM-ABC transporter signature motif; other site 264198013674 cytosine deaminase; Validated; Region: PRK07572 264198013675 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 264198013676 active site 264198013677 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198013678 metal binding site [ion binding]; metal-binding site 264198013679 active site 264198013680 I-site; other site 264198013681 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 264198013682 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 264198013683 Predicted esterase [General function prediction only]; Region: COG0627 264198013684 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198013685 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 264198013686 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 264198013687 substrate binding site [chemical binding]; other site 264198013688 catalytic Zn binding site [ion binding]; other site 264198013689 NAD binding site [chemical binding]; other site 264198013690 structural Zn binding site [ion binding]; other site 264198013691 dimer interface [polypeptide binding]; other site 264198013692 Cache domain; Region: Cache_2; cl07034 264198013693 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264198013694 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198013695 dimer interface [polypeptide binding]; other site 264198013696 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 264198013697 putative CheW interface [polypeptide binding]; other site 264198013698 ATP/ADP translocase [Energy production and conversion]; Region: COG3202; cl03940 264198013699 ATP/ADP translocase [Energy production and conversion]; Region: COG3202; cl03940 264198013700 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 264198013701 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 264198013702 active site 264198013703 catalytic tetrad [active] 264198013704 amino acid transporter; Region: 2A0306; TIGR00909 264198013705 Spore germination protein; Region: Spore_permease; cl15802 264198013706 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 264198013707 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 264198013708 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 264198013709 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198013710 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264198013711 TM-ABC transporter signature motif; other site 264198013712 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264198013713 TM-ABC transporter signature motif; other site 264198013714 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264198013715 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 264198013716 Walker A/P-loop; other site 264198013717 ATP binding site [chemical binding]; other site 264198013718 Q-loop/lid; other site 264198013719 ABC transporter signature motif; other site 264198013720 Walker B; other site 264198013721 D-loop; other site 264198013722 H-loop/switch region; other site 264198013723 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264198013724 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 264198013725 Walker A/P-loop; other site 264198013726 ATP binding site [chemical binding]; other site 264198013727 Q-loop/lid; other site 264198013728 ABC transporter signature motif; other site 264198013729 Walker B; other site 264198013730 D-loop; other site 264198013731 H-loop/switch region; other site 264198013732 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 264198013733 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 264198013734 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198013735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 264198013736 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 264198013737 active site 264198013738 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 264198013739 active site 264198013740 catalytic residues [active] 264198013741 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 264198013742 putative acyl-acceptor binding pocket; other site 264198013743 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 264198013744 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198013745 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 264198013746 GntP family permease; Region: GntP_permease; pfam02447 264198013747 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 264198013748 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 264198013749 homotrimer interaction site [polypeptide binding]; other site 264198013750 putative active site [active] 264198013751 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 264198013752 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 264198013753 active site 264198013754 putative substrate binding pocket [chemical binding]; other site 264198013755 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 264198013756 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 264198013757 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 264198013758 putative active site [active] 264198013759 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 264198013760 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 264198013761 dimer interface [polypeptide binding]; other site 264198013762 active site 264198013763 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264198013764 substrate binding site [chemical binding]; other site 264198013765 catalytic residue [active] 264198013766 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 264198013767 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 264198013768 substrate binding site [chemical binding]; other site 264198013769 ATP binding site [chemical binding]; other site 264198013770 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 264198013771 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 264198013772 active site 264198013773 intersubunit interface [polypeptide binding]; other site 264198013774 catalytic residue [active] 264198013775 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 264198013776 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264198013777 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 264198013778 Domain of unknown function DUF21; Region: DUF21; pfam01595 264198013779 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 264198013780 Transporter associated domain; Region: CorC_HlyC; cl08393 264198013781 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 264198013782 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264198013783 non-specific DNA binding site [nucleotide binding]; other site 264198013784 salt bridge; other site 264198013785 sequence-specific DNA binding site [nucleotide binding]; other site 264198013786 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 264198013787 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 264198013788 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 264198013789 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 264198013790 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 264198013791 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 264198013792 Membrane glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: MdoH; COG2943 264198013793 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 264198013794 Ligand binding site; other site 264198013795 DXD motif; other site 264198013796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198013797 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 264198013798 putative substrate translocation pore; other site 264198013799 mechanosensitive channel MscS; Provisional; Region: PRK10334 264198013800 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264198013801 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 264198013802 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 264198013803 IHF dimer interface [polypeptide binding]; other site 264198013804 IHF - DNA interface [nucleotide binding]; other site 264198013805 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 264198013806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 264198013807 CreA protein; Region: CreA; pfam05981 264198013808 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 264198013809 AMP-binding enzyme; Region: AMP-binding; cl15778 264198013810 AMP-binding enzyme; Region: AMP-binding; cl15778 264198013811 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 264198013812 classical (c) SDRs; Region: SDR_c; cd05233 264198013813 NAD(P) binding site [chemical binding]; other site 264198013814 active site 264198013815 N-acetyltransferase; Region: Acetyltransf_2; cl00949 264198013816 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198013817 ligand binding site [chemical binding]; other site 264198013818 flexible hinge region; other site 264198013819 Helix-turn-helix domains; Region: HTH; cl00088 264198013820 Protein of unknown function (DUF962); Region: DUF962; cl01879 264198013821 sensor protein PhoQ; Provisional; Region: PRK10815 264198013822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198013823 ATP binding site [chemical binding]; other site 264198013824 Mg2+ binding site [ion binding]; other site 264198013825 G-X-G motif; other site 264198013826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198013827 active site 264198013828 dimerization interface [polypeptide binding]; other site 264198013829 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198013830 DNA binding site [nucleotide binding] 264198013831 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 264198013832 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 264198013833 putative substrate binding pocket [chemical binding]; other site 264198013834 trimer interface [polypeptide binding]; other site 264198013835 MgtC family; Region: MgtC; pfam02308 264198013836 Arginase family; Region: Arginase; cl00306 264198013837 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264198013838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198013839 active site 264198013840 phosphorylation site [posttranslational modification] 264198013841 intermolecular recognition site; other site 264198013842 dimerization interface [polypeptide binding]; other site 264198013843 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198013844 DNA binding site [nucleotide binding] 264198013845 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 264198013846 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 264198013847 putative active site [active] 264198013848 catalytic site [active] 264198013849 Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161 264198013850 putative active site [active] 264198013851 catalytic site [active] 264198013852 Helix-turn-helix domains; Region: HTH; cl00088 264198013853 WHG domain; Region: WHG; pfam13305 264198013854 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264198013855 Zn2+ binding site [ion binding]; other site 264198013856 Mg2+ binding site [ion binding]; other site 264198013857 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 264198013858 FMN binding site [chemical binding]; other site 264198013859 active site 264198013860 substrate binding site [chemical binding]; other site 264198013861 catalytic residue [active] 264198013862 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264198013863 dimerization interface [polypeptide binding]; other site 264198013864 putative DNA binding site [nucleotide binding]; other site 264198013865 putative Zn2+ binding site [ion binding]; other site 264198013866 AMP-binding enzyme; Region: AMP-binding; cl15778 264198013867 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 264198013868 catalytic residues [active] 264198013869 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 264198013870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198013871 active site 264198013872 phosphorylation site [posttranslational modification] 264198013873 intermolecular recognition site; other site 264198013874 dimerization interface [polypeptide binding]; other site 264198013875 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264198013876 Zn2+ binding site [ion binding]; other site 264198013877 Mg2+ binding site [ion binding]; other site 264198013878 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 264198013879 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 264198013880 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198013881 dimer interface [polypeptide binding]; other site 264198013882 phosphorylation site [posttranslational modification] 264198013883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198013884 ATP binding site [chemical binding]; other site 264198013885 Mg2+ binding site [ion binding]; other site 264198013886 G-X-G motif; other site 264198013887 Response regulator receiver domain; Region: Response_reg; pfam00072 264198013888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198013889 active site 264198013890 phosphorylation site [posttranslational modification] 264198013891 intermolecular recognition site; other site 264198013892 dimerization interface [polypeptide binding]; other site 264198013893 Response regulator receiver domain; Region: Response_reg; pfam00072 264198013894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198013895 active site 264198013896 phosphorylation site [posttranslational modification] 264198013897 intermolecular recognition site; other site 264198013898 dimerization interface [polypeptide binding]; other site 264198013899 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198013900 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 264198013901 dimer interface [polypeptide binding]; other site 264198013902 ligand binding site [chemical binding]; other site 264198013903 transcriptional regulator EutR; Provisional; Region: PRK10130 264198013904 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198013905 amidase; Provisional; Region: PRK07486 264198013906 Amidase; Region: Amidase; cl11426 264198013907 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 264198013908 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198013909 NAD(P) binding site [chemical binding]; other site 264198013910 catalytic residues [active] 264198013911 Cytochrome c; Region: Cytochrom_C; cl11414 264198013912 Methylamine dehydrogenase, L chain; Region: Me-amine-dh_L; cl03812 264198013913 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 264198013914 methylamine dehydrogenase (amicyanin) heavy chain; Region: TTQ_MADH_Hv; TIGR02658 264198013915 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264198013916 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 264198013917 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198013918 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198013919 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 264198013920 Fusaric acid resistance protein family; Region: FUSC; pfam04632 264198013921 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198013922 Helix-turn-helix domains; Region: HTH; cl00088 264198013923 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 264198013924 putative dimerization interface [polypeptide binding]; other site 264198013925 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 264198013926 putative active site [active] 264198013927 Cupin domain; Region: Cupin_2; cl09118 264198013928 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264198013929 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 264198013930 Protein export membrane protein; Region: SecD_SecF; cl14618 264198013931 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 264198013932 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198013933 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198013934 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 264198013935 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 264198013936 putative molybdopterin cofactor binding site [chemical binding]; other site 264198013937 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 264198013938 putative molybdopterin cofactor binding site; other site 264198013939 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 264198013940 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 264198013941 dimer interface [polypeptide binding]; other site 264198013942 putative functional site; other site 264198013943 putative MPT binding site; other site 264198013944 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 264198013945 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198013946 DNA-binding site [nucleotide binding]; DNA binding site 264198013947 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198013948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198013949 homodimer interface [polypeptide binding]; other site 264198013950 catalytic residue [active] 264198013951 Ribosomal protein S19e; Region: Ribosomal_S19e; cl00969 264198013952 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 264198013953 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198013954 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198013955 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 264198013956 Fusaric acid resistance protein family; Region: FUSC; pfam04632 264198013957 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 264198013958 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 264198013959 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 264198013960 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 264198013961 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 264198013962 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198013963 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 264198013964 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264198013965 Coenzyme A binding pocket [chemical binding]; other site 264198013966 Protein of unknown function (DUF419); Region: DUF419; cl15265 264198013967 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198013968 PAS domain; Region: PAS_9; pfam13426 264198013969 putative active site [active] 264198013970 heme pocket [chemical binding]; other site 264198013971 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198013972 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 264198013973 putative active site [active] 264198013974 heme pocket [chemical binding]; other site 264198013975 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198013976 dimer interface [polypeptide binding]; other site 264198013977 phosphorylation site [posttranslational modification] 264198013978 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198013979 ATP binding site [chemical binding]; other site 264198013980 Mg2+ binding site [ion binding]; other site 264198013981 G-X-G motif; other site 264198013982 Response regulator receiver domain; Region: Response_reg; pfam00072 264198013983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198013984 active site 264198013985 phosphorylation site [posttranslational modification] 264198013986 intermolecular recognition site; other site 264198013987 dimerization interface [polypeptide binding]; other site 264198013988 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 264198013989 tartrate dehydrogenase; Provisional; Region: PRK08194 264198013990 Helix-turn-helix domains; Region: HTH; cl00088 264198013991 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 264198013992 PAS domain; Region: PAS_9; pfam13426 264198013993 drug efflux system protein MdtG; Provisional; Region: PRK09874 264198013994 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198013995 putative substrate translocation pore; other site 264198013996 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264198013997 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198013998 DNA-binding site [nucleotide binding]; DNA binding site 264198013999 FCD domain; Region: FCD; cl11656 264198014000 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 264198014001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198014002 D-galactonate transporter; Region: 2A0114; TIGR00893 264198014003 putative substrate translocation pore; other site 264198014004 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 264198014005 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 264198014006 active site pocket [active] 264198014007 Cupin domain; Region: Cupin_2; cl09118 264198014008 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264198014009 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198014010 Helix-turn-helix domains; Region: HTH; cl00088 264198014011 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198014012 putative effector binding pocket; other site 264198014013 dimerization interface [polypeptide binding]; other site 264198014014 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 264198014015 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 264198014016 NAD(P) binding site [chemical binding]; other site 264198014017 homotetramer interface [polypeptide binding]; other site 264198014018 homodimer interface [polypeptide binding]; other site 264198014019 active site 264198014020 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 264198014021 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 264198014022 active site 264198014023 dimer interface [polypeptide binding]; other site 264198014024 metal binding site [ion binding]; metal-binding site 264198014025 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 264198014026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198014027 Helix-turn-helix domains; Region: HTH; cl00088 264198014028 LysR family transcriptional regulator; Provisional; Region: PRK14997 264198014029 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198014030 putative effector binding pocket; other site 264198014031 dimerization interface [polypeptide binding]; other site 264198014032 hypothetical protein; Provisional; Region: PRK08204 264198014033 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198014034 active site 264198014035 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 264198014036 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 264198014037 Walker A/P-loop; other site 264198014038 ATP binding site [chemical binding]; other site 264198014039 Q-loop/lid; other site 264198014040 ABC transporter signature motif; other site 264198014041 Walker B; other site 264198014042 D-loop; other site 264198014043 H-loop/switch region; other site 264198014044 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 264198014045 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 264198014046 TM-ABC transporter signature motif; other site 264198014047 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 264198014048 TM-ABC transporter signature motif; other site 264198014049 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 264198014050 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 264198014051 ligand binding site [chemical binding]; other site 264198014052 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 264198014053 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 264198014054 dimer interface [polypeptide binding]; other site 264198014055 active site 264198014056 YCII-related domain; Region: YCII; cl00999 264198014057 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 264198014058 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 264198014059 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198014060 Predicted permease [General function prediction only]; Region: COG2985 264198014061 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 264198014062 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 264198014063 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 264198014064 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 264198014065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198014066 NMT1-like family; Region: NMT1_2; cl15260 264198014067 amidase; Provisional; Region: PRK07486 264198014068 Amidase; Region: Amidase; cl11426 264198014069 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198014070 Helix-turn-helix domains; Region: HTH; cl00088 264198014071 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_5; cd08426 264198014072 putative dimerization interface [polypeptide binding]; other site 264198014073 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 264198014074 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198014075 putative metal binding site [ion binding]; other site 264198014076 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198014077 Helix-turn-helix domains; Region: HTH; cl00088 264198014078 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 264198014079 putative dimerization interface [polypeptide binding]; other site 264198014080 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 264198014081 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198014082 DNA-binding site [nucleotide binding]; DNA binding site 264198014083 UTRA domain; Region: UTRA; cl01230 264198014084 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 264198014085 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 264198014086 putative active site [active] 264198014087 putative catalytic site [active] 264198014088 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 264198014089 active site 2 [active] 264198014090 active site 1 [active] 264198014091 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198014092 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198014093 active site 264198014094 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198014095 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198014096 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 264198014097 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 264198014098 active site 264198014099 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 264198014100 DUF35 OB-fold domain; Region: DUF35; pfam01796 264198014101 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198014102 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198014103 active site 264198014104 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 264198014105 AMP-binding enzyme; Region: AMP-binding; cl15778 264198014106 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198014107 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 264198014108 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 264198014109 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198014110 DNA-binding site [nucleotide binding]; DNA binding site 264198014111 UTRA domain; Region: UTRA; cl01230 264198014112 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 264198014113 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 264198014114 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 264198014115 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198014116 NAD binding site [chemical binding]; other site 264198014117 catalytic residues [active] 264198014118 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 264198014119 PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); Region: PQQ_ADH_II; cd10279 264198014120 Trp docking motif [polypeptide binding]; other site 264198014121 cytochrome domain interface [polypeptide binding]; other site 264198014122 active site 264198014123 Cytochrome c; Region: Cytochrom_C; cl11414 264198014124 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198014125 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198014126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198014127 NMT1-like family; Region: NMT1_2; cl15260 264198014128 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 264198014129 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198014130 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198014131 DNA binding residues [nucleotide binding] 264198014132 dimerization interface [polypeptide binding]; other site 264198014133 feruloyl-CoA synthase; Reviewed; Region: PRK08180 264198014134 AMP-binding enzyme; Region: AMP-binding; cl15778 264198014135 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198014136 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198014137 active site 264198014138 lipid-transfer protein; Provisional; Region: PRK08256 264198014139 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 264198014140 active site 264198014141 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 264198014142 active site 264198014143 catalytic site [active] 264198014144 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 264198014145 active site 264198014146 catalytic site [active] 264198014147 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 264198014148 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198014149 NAD(P) binding site [chemical binding]; other site 264198014150 active site 264198014151 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198014152 trimer interface [polypeptide binding]; other site 264198014153 eyelet of channel; other site 264198014154 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 264198014155 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198014156 Predicted esterase [General function prediction only]; Region: COG0400 264198014157 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198014158 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 264198014159 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 264198014160 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 264198014161 Walker A/P-loop; other site 264198014162 ATP binding site [chemical binding]; other site 264198014163 Q-loop/lid; other site 264198014164 ABC transporter signature motif; other site 264198014165 Walker B; other site 264198014166 D-loop; other site 264198014167 H-loop/switch region; other site 264198014168 NMT1-like family; Region: NMT1_2; cl15260 264198014169 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 264198014170 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 264198014171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198014172 dimer interface [polypeptide binding]; other site 264198014173 conserved gate region; other site 264198014174 putative PBP binding loops; other site 264198014175 ABC-ATPase subunit interface; other site 264198014176 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 264198014177 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264198014178 Coenzyme A binding pocket [chemical binding]; other site 264198014179 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 264198014180 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198014181 active site 264198014182 Protein of unknown function (DUF1045); Region: DUF1045; cl15435 264198014183 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 264198014184 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198014185 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 264198014186 active site 264198014187 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 264198014188 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198014189 DNA-binding site [nucleotide binding]; DNA binding site 264198014190 UTRA domain; Region: UTRA; cl01230 264198014191 Phosphonate metabolism protein PhnG; Region: PhnG; cl01454 264198014192 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; cl01455 264198014193 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; cl01456 264198014194 Phosphonate metabolism protein PhnJ; Region: PhnJ; cl01457 264198014195 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 264198014196 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 264198014197 Walker A/P-loop; other site 264198014198 ATP binding site [chemical binding]; other site 264198014199 Q-loop/lid; other site 264198014200 ABC transporter signature motif; other site 264198014201 Walker B; other site 264198014202 D-loop; other site 264198014203 H-loop/switch region; other site 264198014204 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 264198014205 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 264198014206 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198014207 Walker A/P-loop; other site 264198014208 ATP binding site [chemical binding]; other site 264198014209 Q-loop/lid; other site 264198014210 ABC transporter signature motif; other site 264198014211 Walker B; other site 264198014212 D-loop; other site 264198014213 H-loop/switch region; other site 264198014214 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 264198014215 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198014216 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 264198014217 active site 264198014218 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198014219 active site 264198014220 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 264198014221 active site 264198014222 metal binding site [ion binding]; metal-binding site 264198014223 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 264198014224 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198014225 Walker A/P-loop; other site 264198014226 ATP binding site [chemical binding]; other site 264198014227 Q-loop/lid; other site 264198014228 ABC transporter signature motif; other site 264198014229 Walker B; other site 264198014230 D-loop; other site 264198014231 H-loop/switch region; other site 264198014232 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 264198014233 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198014234 DNA-binding site [nucleotide binding]; DNA binding site 264198014235 UTRA domain; Region: UTRA; cl01230 264198014236 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 264198014237 Protein of unknown function (DUF3079); Region: DUF3079; pfam11278 264198014238 TolB amino-terminal domain; Region: TolB_N; cl00639 264198014239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 264198014240 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198014241 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 264198014242 tetramerization interface [polypeptide binding]; other site 264198014243 NAD(P) binding site [chemical binding]; other site 264198014244 catalytic residues [active] 264198014245 Flagellar transcriptional activator (FlhC); Region: FlhC; cl05036 264198014246 Flagellar transcriptional activator (FlhD); Region: FlhD; cl05012 264198014247 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 264198014248 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198014249 ligand binding site [chemical binding]; other site 264198014250 flexible hinge region; other site 264198014251 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 264198014252 putative switch regulator; other site 264198014253 non-specific DNA interactions [nucleotide binding]; other site 264198014254 DNA binding site [nucleotide binding] 264198014255 sequence specific DNA binding site [nucleotide binding]; other site 264198014256 putative cAMP binding site [chemical binding]; other site 264198014257 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 264198014258 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 264198014259 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198014260 NMT1-like family; Region: NMT1_2; cl15260 264198014261 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198014262 Helix-turn-helix domains; Region: HTH; cl00088 264198014263 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198014264 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198014265 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 264198014266 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264198014267 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 264198014268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198014269 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 264198014270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198014271 putative substrate translocation pore; other site 264198014272 YabG peptidase U57; Region: Peptidase_U57; cl05250 264198014273 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 264198014274 BON domain; Region: BON; cl02771 264198014275 Protein of unknown function (DUF421); Region: DUF421; cl00990 264198014276 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 264198014277 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 264198014278 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 264198014279 active site 264198014280 homodimer interface [polypeptide binding]; other site 264198014281 catalytic site [active] 264198014282 acceptor binding site [chemical binding]; other site 264198014283 trehalose synthase; Region: treS_nterm; TIGR02456 264198014284 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 264198014285 active site 264198014286 catalytic site [active] 264198014287 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 264198014288 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 264198014289 glycogen branching enzyme; Provisional; Region: PRK05402 264198014290 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 264198014291 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 264198014292 active site 264198014293 catalytic site [active] 264198014294 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 264198014295 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 264198014296 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 264198014297 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 264198014298 active site 264198014299 catalytic site [active] 264198014300 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 264198014301 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 264198014302 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 264198014303 homodimer interface [polypeptide binding]; other site 264198014304 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 264198014305 active site pocket [active] 264198014306 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 264198014307 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 264198014308 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 264198014309 catalytic site [active] 264198014310 active site 264198014311 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 264198014312 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 264198014313 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 264198014314 active site 264198014315 catalytic site [active] 264198014316 BON domain; Region: BON; cl02771 264198014317 BON domain; Region: BON; cl02771 264198014318 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 264198014319 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 264198014320 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 264198014321 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 264198014322 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 264198014323 excinuclease ABC, A subunit; Region: uvra; TIGR00630 264198014324 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198014325 Walker A/P-loop; other site 264198014326 ATP binding site [chemical binding]; other site 264198014327 Q-loop/lid; other site 264198014328 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 264198014329 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 264198014330 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 264198014331 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 264198014332 dimerization interface [polypeptide binding]; other site 264198014333 active site 264198014334 Helix-turn-helix domains; Region: HTH; cl00088 264198014335 AsnC family; Region: AsnC_trans_reg; pfam01037 264198014336 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 264198014337 Helix-turn-helix domains; Region: HTH; cl00088 264198014338 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 264198014339 putative dimerization interface [polypeptide binding]; other site 264198014340 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 264198014341 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 264198014342 THF binding site; other site 264198014343 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 264198014344 substrate binding site [chemical binding]; other site 264198014345 THF binding site; other site 264198014346 zinc-binding site [ion binding]; other site 264198014347 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 264198014348 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264198014349 N-terminal plug; other site 264198014350 ligand-binding site [chemical binding]; other site 264198014351 Uncharacterized conserved protein [Function unknown]; Region: COG5361 264198014352 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 264198014353 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 264198014354 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 264198014355 nudix motif; other site 264198014356 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264198014357 Putative zinc-finger; Region: zf-HC2; cl15806 264198014358 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 264198014359 RNA polymerase sigma factor; Provisional; Region: PRK12533 264198014360 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264198014361 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264198014362 DNA binding residues [nucleotide binding] 264198014363 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264198014364 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 264198014365 active site 264198014366 metal binding site [ion binding]; metal-binding site 264198014367 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 264198014368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198014369 S-adenosylmethionine binding site [chemical binding]; other site 264198014370 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198014371 metal binding site [ion binding]; metal-binding site 264198014372 active site 264198014373 I-site; other site 264198014374 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198014375 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198014376 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198014377 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198014378 active site 264198014379 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 264198014380 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198014381 tetrameric interface [polypeptide binding]; other site 264198014382 NAD binding site [chemical binding]; other site 264198014383 catalytic residues [active] 264198014384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198014385 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 264198014386 enoyl-CoA hydratase; Provisional; Region: PRK09076 264198014387 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198014388 substrate binding site [chemical binding]; other site 264198014389 oxyanion hole (OAH) forming residues; other site 264198014390 trimer interface [polypeptide binding]; other site 264198014391 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 264198014392 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198014393 substrate binding site [chemical binding]; other site 264198014394 oxyanion hole (OAH) forming residues; other site 264198014395 trimer interface [polypeptide binding]; other site 264198014396 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 264198014397 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 264198014398 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 264198014399 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 264198014400 putative NAD(P) binding site [chemical binding]; other site 264198014401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198014402 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 264198014403 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198014404 Helix-turn-helix domains; Region: HTH; cl00088 264198014405 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198014406 DNA-binding site [nucleotide binding]; DNA binding site 264198014407 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198014408 aminotransferase; Validated; Region: PRK08175 264198014409 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198014410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198014411 homodimer interface [polypeptide binding]; other site 264198014412 catalytic residue [active] 264198014413 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 264198014414 putative active site [active] 264198014415 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 264198014416 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 264198014417 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 264198014418 FAD binding pocket [chemical binding]; other site 264198014419 FAD binding motif [chemical binding]; other site 264198014420 phosphate binding motif [ion binding]; other site 264198014421 NAD binding pocket [chemical binding]; other site 264198014422 Helix-turn-helix domains; Region: HTH; cl00088 264198014423 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264198014424 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 264198014425 FAD binding domain; Region: FAD_binding_4; pfam01565 264198014426 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 264198014427 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 264198014428 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198014429 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 264198014430 tetramerization interface [polypeptide binding]; other site 264198014431 NAD(P) binding site [chemical binding]; other site 264198014432 catalytic residues [active] 264198014433 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 264198014434 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 264198014435 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 264198014436 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198014437 NMT1-like family; Region: NMT1_2; cl15260 264198014438 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 264198014439 Helix-turn-helix domains; Region: HTH; cl00088 264198014440 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198014441 dimerization interface [polypeptide binding]; other site 264198014442 NeuB family; Region: NeuB; cl00496 264198014443 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 264198014444 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 264198014445 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 264198014446 homodimer interface [polypeptide binding]; other site 264198014447 substrate-cofactor binding pocket; other site 264198014448 catalytic residue [active] 264198014449 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 264198014450 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 264198014451 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 264198014452 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 264198014453 Sulfatase; Region: Sulfatase; cl10460 264198014454 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 264198014455 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 264198014456 Phosphoesterase family; Region: Phosphoesterase; cl15450 264198014457 Domain of unknown function (DUF756); Region: DUF756; pfam05506 264198014458 Domain of unknown function (DUF756); Region: DUF756; pfam05506 264198014459 Helix-turn-helix domains; Region: HTH; cl00088 264198014460 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 264198014461 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264198014462 dimerization interface [polypeptide binding]; other site 264198014463 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_7; cd03862 264198014464 putative active site [active] 264198014465 Zn binding site [ion binding]; other site 264198014466 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264198014467 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198014468 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198014469 Helix-turn-helix domains; Region: HTH; cl00088 264198014470 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198014471 Helix-turn-helix domains; Region: HTH; cl00088 264198014472 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 264198014473 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 264198014474 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198014475 Helix-turn-helix domains; Region: HTH; cl00088 264198014476 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198014477 dimerization interface [polypeptide binding]; other site 264198014478 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 264198014479 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 264198014480 metal binding site [ion binding]; metal-binding site 264198014481 putative dimer interface [polypeptide binding]; other site 264198014482 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198014483 NMT1-like family; Region: NMT1_2; cl15260 264198014484 putative transporter; Provisional; Region: PRK10504 264198014485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198014486 putative substrate translocation pore; other site 264198014487 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198014488 Helix-turn-helix domains; Region: HTH; cl00088 264198014489 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198014490 dimerization interface [polypeptide binding]; other site 264198014491 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 264198014492 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 264198014493 dimerization interface [polypeptide binding]; other site 264198014494 putative active cleft [active] 264198014495 acyl-CoA synthetase; Validated; Region: PRK08162 264198014496 AMP-binding enzyme; Region: AMP-binding; cl15778 264198014497 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198014498 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264198014499 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198014500 ligand binding site [chemical binding]; other site 264198014501 flexible hinge region; other site 264198014502 Helix-turn-helix domains; Region: HTH; cl00088 264198014503 EamA-like transporter family; Region: EamA; cl01037 264198014504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198014505 putative substrate translocation pore; other site 264198014506 Protein of unknown function (DUF2501); Region: DUF2501; cl08197 264198014507 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 264198014508 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198014509 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 264198014510 active site 264198014511 FMN binding site [chemical binding]; other site 264198014512 substrate binding site [chemical binding]; other site 264198014513 homotetramer interface [polypeptide binding]; other site 264198014514 catalytic residue [active] 264198014515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198014516 putative substrate translocation pore; other site 264198014517 Helix-turn-helix domains; Region: HTH; cl00088 264198014518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198014519 putative substrate translocation pore; other site 264198014520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198014521 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 264198014522 classical (c) SDRs; Region: SDR_c; cd05233 264198014523 NAD(P) binding site [chemical binding]; other site 264198014524 active site 264198014525 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198014526 Helix-turn-helix domains; Region: HTH; cl00088 264198014527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198014528 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198014529 putative substrate translocation pore; other site 264198014530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198014531 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 264198014532 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 264198014533 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 264198014534 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 264198014535 generic binding surface I; other site 264198014536 generic binding surface II; other site 264198014537 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 264198014538 putative active site [active] 264198014539 putative catalytic site [active] 264198014540 putative Mg binding site IVb [ion binding]; other site 264198014541 putative phosphate binding site [ion binding]; other site 264198014542 putative DNA binding site [nucleotide binding]; other site 264198014543 putative Mg binding site IVa [ion binding]; other site 264198014544 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 264198014545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198014546 putative substrate translocation pore; other site 264198014547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198014548 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 264198014549 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 264198014550 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264198014551 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 264198014552 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264198014553 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198014554 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198014555 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 264198014556 transcriptional regulator; Provisional; Region: PRK10632 264198014557 Helix-turn-helix domains; Region: HTH; cl00088 264198014558 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 264198014559 putative effector binding pocket; other site 264198014560 putative dimerization interface [polypeptide binding]; other site 264198014561 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 264198014562 E-class dimer interface [polypeptide binding]; other site 264198014563 P-class dimer interface [polypeptide binding]; other site 264198014564 active site 264198014565 Cu2+ binding site [ion binding]; other site 264198014566 Zn2+ binding site [ion binding]; other site 264198014567 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 264198014568 Helix-turn-helix domains; Region: HTH; cl00088 264198014569 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 264198014570 substrate binding pocket [chemical binding]; other site 264198014571 dimerization interface [polypeptide binding]; other site 264198014572 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 264198014573 iron-sulfur cluster [ion binding]; other site 264198014574 [2Fe-2S] cluster binding site [ion binding]; other site 264198014575 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 264198014576 alpha subunit interface [polypeptide binding]; other site 264198014577 active site 264198014578 substrate binding site [chemical binding]; other site 264198014579 Fe binding site [ion binding]; other site 264198014580 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 264198014581 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 264198014582 FMN-binding pocket [chemical binding]; other site 264198014583 flavin binding motif; other site 264198014584 phosphate binding motif [ion binding]; other site 264198014585 beta-alpha-beta structure motif; other site 264198014586 NAD binding pocket [chemical binding]; other site 264198014587 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198014588 catalytic loop [active] 264198014589 iron binding site [ion binding]; other site 264198014590 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264198014591 GAF domain; Region: GAF_2; pfam13185 264198014592 GAF domain; Region: GAF; cl15785 264198014593 PAS fold; Region: PAS_4; pfam08448 264198014594 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 264198014595 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198014596 metal binding site [ion binding]; metal-binding site 264198014597 active site 264198014598 I-site; other site 264198014599 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264198014600 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264198014601 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 264198014602 HSP70 interaction site [polypeptide binding]; other site 264198014603 serine racemase; Region: PLN02970 264198014604 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 264198014605 tetramer interface [polypeptide binding]; other site 264198014606 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198014607 catalytic residue [active] 264198014608 Phasin protein; Region: Phasin_2; cl11491 264198014609 multidrug resistance protein MdtN; Provisional; Region: PRK10476 264198014610 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198014611 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198014612 Fusaric acid resistance protein family; Region: FUSC; pfam04632 264198014613 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 264198014614 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 264198014615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198014616 NMT1-like family; Region: NMT1_2; cl15260 264198014617 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 264198014618 Cytochrome c; Region: Cytochrom_C; cl11414 264198014619 Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; cl01820 264198014620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198014621 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 264198014622 Helix-turn-helix domains; Region: HTH; cl00088 264198014623 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198014624 dimerization interface [polypeptide binding]; other site 264198014625 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 264198014626 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198014627 dimer interface [polypeptide binding]; other site 264198014628 phosphorylation site [posttranslational modification] 264198014629 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198014630 ATP binding site [chemical binding]; other site 264198014631 Mg2+ binding site [ion binding]; other site 264198014632 G-X-G motif; other site 264198014633 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 264198014634 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 264198014635 metal binding site [ion binding]; metal-binding site 264198014636 dimer interface [polypeptide binding]; other site 264198014637 BON domain; Region: BON; cl02771 264198014638 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 264198014639 BON domain; Region: BON; cl02771 264198014640 BON domain; Region: BON; cl02771 264198014641 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 264198014642 AMP-binding enzyme; Region: AMP-binding; cl15778 264198014643 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198014644 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 264198014645 active site 264198014646 DNA binding site [nucleotide binding] 264198014647 Int/Topo IB signature motif; other site 264198014648 catalytic residues [active] 264198014649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4318 264198014650 Putative ParB-like nuclease; Region: ParBc_2; pfam08857 264198014651 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 264198014652 BON domain; Region: BON; cl02771 264198014653 short chain dehydrogenase; Provisional; Region: PRK06701 264198014654 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 264198014655 NAD binding site [chemical binding]; other site 264198014656 metal binding site [ion binding]; metal-binding site 264198014657 active site 264198014658 Putative ParB-like nuclease; Region: ParBc_2; pfam08857 264198014659 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 264198014660 BON domain; Region: BON; cl02771 264198014661 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 264198014662 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 264198014663 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 264198014664 putative active site [active] 264198014665 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 264198014666 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 264198014667 active site 264198014668 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 264198014669 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 264198014670 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 264198014671 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 264198014672 putative active site [active] 264198014673 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 264198014674 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264198014675 active site 264198014676 motif I; other site 264198014677 motif II; other site 264198014678 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198014679 classical (c) SDRs; Region: SDR_c; cd05233 264198014680 NAD(P) binding site [chemical binding]; other site 264198014681 active site 264198014682 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 264198014683 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 264198014684 putative ADP-binding pocket [chemical binding]; other site 264198014685 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 264198014686 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 264198014687 NAD binding site [chemical binding]; other site 264198014688 putative substrate binding site 2 [chemical binding]; other site 264198014689 putative substrate binding site 1 [chemical binding]; other site 264198014690 active site 264198014691 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 264198014692 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 264198014693 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 264198014694 Probable Catalytic site; other site 264198014695 metal-binding site 264198014696 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 264198014697 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 264198014698 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198014699 Walker A/P-loop; other site 264198014700 ATP binding site [chemical binding]; other site 264198014701 Q-loop/lid; other site 264198014702 ABC transporter signature motif; other site 264198014703 Walker B; other site 264198014704 D-loop; other site 264198014705 H-loop/switch region; other site 264198014706 sensory histidine kinase CreC; Provisional; Region: PRK11100 264198014707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198014708 Response regulator receiver domain; Region: Response_reg; pfam00072 264198014709 active site 264198014710 phosphorylation site [posttranslational modification] 264198014711 intermolecular recognition site; other site 264198014712 dimerization interface [polypeptide binding]; other site 264198014713 FOG: CBS domain [General function prediction only]; Region: COG0517 264198014714 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 264198014715 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 264198014716 Fe-S cluster binding site [ion binding]; other site 264198014717 active site 264198014718 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667 264198014719 nudix motif; other site 264198014720 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 264198014721 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 264198014722 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 264198014723 octamer interface [polypeptide binding]; other site 264198014724 active site 264198014725 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 264198014726 Helix-turn-helix domains; Region: HTH; cl00088 264198014727 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 264198014728 dimerizarion interface [polypeptide binding]; other site 264198014729 CrgA pocket; other site 264198014730 substrate binding pocket [chemical binding]; other site 264198014731 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 264198014732 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 264198014733 dimer interface [polypeptide binding]; other site 264198014734 active site 264198014735 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 264198014736 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 264198014737 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 264198014738 putative alpha subunit interface [polypeptide binding]; other site 264198014739 putative active site [active] 264198014740 putative substrate binding site [chemical binding]; other site 264198014741 Fe binding site [ion binding]; other site 264198014742 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 264198014743 inter-subunit interface; other site 264198014744 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 264198014745 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198014746 catalytic loop [active] 264198014747 iron binding site [ion binding]; other site 264198014748 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 264198014749 FAD binding pocket [chemical binding]; other site 264198014750 FAD binding motif [chemical binding]; other site 264198014751 phosphate binding motif [ion binding]; other site 264198014752 beta-alpha-beta structure motif; other site 264198014753 NAD binding pocket [chemical binding]; other site 264198014754 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 264198014755 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198014756 putative NAD(P) binding site [chemical binding]; other site 264198014757 active site 264198014758 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 264198014759 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 264198014760 dimanganese center [ion binding]; other site 264198014761 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 264198014762 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 264198014763 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 264198014764 Helix-turn-helix domains; Region: HTH; cl00088 264198014765 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 264198014766 putative dimerization interface [polypeptide binding]; other site 264198014767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198014768 NMT1-like family; Region: NMT1_2; cl15260 264198014769 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 264198014770 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198014771 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 264198014772 FAD binding domain; Region: FAD_binding_4; pfam01565 264198014773 Berberine and berberine like; Region: BBE; pfam08031 264198014774 Cupin domain; Region: Cupin_2; cl09118 264198014775 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198014776 Helix-turn-helix domains; Region: HTH; cl00088 264198014777 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198014778 dimerization interface [polypeptide binding]; other site 264198014779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198014780 NMT1-like family; Region: NMT1_2; cl15260 264198014781 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198014782 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198014783 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 264198014784 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 264198014785 tetratricopeptide repeat protein; Provisional; Region: PRK11788 264198014786 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264198014787 binding surface 264198014788 TPR repeat; Region: TPR_11; pfam13414 264198014789 TPR motif; other site 264198014790 TPR repeat; Region: TPR_11; pfam13414 264198014791 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 264198014792 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 264198014793 putative homodimer interface [polypeptide binding]; other site 264198014794 putative DNA binding site [nucleotide binding]; other site 264198014795 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 264198014796 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 264198014797 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 264198014798 active site 264198014799 DNA binding site [nucleotide binding] 264198014800 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 264198014801 DNA binding site [nucleotide binding] 264198014802 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 264198014803 nucleotide binding site [chemical binding]; other site 264198014804 Gram-negative bacterial tonB protein; Region: TonB; cl10048 264198014805 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 264198014806 heme-binding residues [chemical binding]; other site 264198014807 The MopB_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding (MopB) proteins. This CD is of the PHLH region homologous to the catalytic molybdopterin-binding subunit of MopB homologs; Region: MopB_PHLH; cd02764 264198014808 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 264198014809 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 264198014810 Polysulphide reductase, NrfD; Region: NrfD; cl01295 264198014811 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 264198014812 Cytochrome c; Region: Cytochrom_C; cl11414 264198014813 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 264198014814 Cu(I) binding site [ion binding]; other site 264198014815 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 264198014816 Cytochrome c; Region: Cytochrom_C; cl11414 264198014817 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 264198014818 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 264198014819 D-pathway; other site 264198014820 Low-spin heme binding site [chemical binding]; other site 264198014821 Putative water exit pathway; other site 264198014822 Binuclear center (active site) [active] 264198014823 K-pathway; other site 264198014824 Putative proton exit pathway; other site 264198014825 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 264198014826 Subunit I/III interface [polypeptide binding]; other site 264198014827 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 264198014828 short chain dehydrogenase; Provisional; Region: PRK07109 264198014829 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 264198014830 putative NAD(P) binding site [chemical binding]; other site 264198014831 active site 264198014832 thiamine pyrophosphate protein; Provisional; Region: PRK08273 264198014833 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 264198014834 PYR/PP interface [polypeptide binding]; other site 264198014835 dimer interface [polypeptide binding]; other site 264198014836 tetramer interface [polypeptide binding]; other site 264198014837 TPP binding site [chemical binding]; other site 264198014838 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 264198014839 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 264198014840 TPP-binding site [chemical binding]; other site 264198014841 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 264198014842 metal binding site [ion binding]; metal-binding site 264198014843 substrate binding pocket [chemical binding]; other site 264198014844 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 264198014845 FAD binding domain; Region: FAD_binding_4; pfam01565 264198014846 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 264198014847 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 264198014848 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 264198014849 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198014850 Helix-turn-helix domains; Region: HTH; cl00088 264198014851 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 264198014852 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 264198014853 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 264198014854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198014855 putative substrate translocation pore; other site 264198014856 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 264198014857 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 264198014858 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 264198014859 catalytic triad [active] 264198014860 dimer interface [polypeptide binding]; other site 264198014861 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 264198014862 hypothetical protein; Provisional; Region: PRK06156 264198014863 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 264198014864 active site 264198014865 metal binding site [ion binding]; metal-binding site 264198014866 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198014867 ligand binding site [chemical binding]; other site 264198014868 flexible hinge region; other site 264198014869 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 264198014870 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198014871 hypothetical protein; Provisional; Region: PRK11239 264198014872 Protein of unknown function, DUF480; Region: DUF480; cl01209 264198014873 flagellar capping protein; Reviewed; Region: fliD; PRK08032 264198014874 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 264198014875 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 264198014876 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 264198014877 active site 264198014878 nucleophile elbow; other site 264198014879 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198014880 NMT1-like family; Region: NMT1_2; cl15260 264198014881 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 264198014882 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 264198014883 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264198014884 ATP-grasp domain; Region: ATP-grasp_4; cl03087 264198014885 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 264198014886 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264198014887 carboxyltransferase (CT) interaction site; other site 264198014888 biotinylation site [posttranslational modification]; other site 264198014889 enoyl-CoA hydratase; Provisional; Region: PRK05995 264198014890 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198014891 substrate binding site [chemical binding]; other site 264198014892 oxyanion hole (OAH) forming residues; other site 264198014893 trimer interface [polypeptide binding]; other site 264198014894 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198014895 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198014896 active site 264198014897 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 264198014898 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 264198014899 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 264198014900 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198014901 Helix-turn-helix domains; Region: HTH; cl00088 264198014902 FixH; Region: FixH; cl01254 264198014903 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 264198014904 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198014905 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198014906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198014907 active site 264198014908 phosphorylation site [posttranslational modification] 264198014909 intermolecular recognition site; other site 264198014910 dimerization interface [polypeptide binding]; other site 264198014911 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198014912 DNA binding residues [nucleotide binding] 264198014913 dimerization interface [polypeptide binding]; other site 264198014914 PAS domain S-box; Region: sensory_box; TIGR00229 264198014915 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 264198014916 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 264198014917 PAS fold; Region: PAS_3; pfam08447 264198014918 putative active site [active] 264198014919 heme pocket [chemical binding]; other site 264198014920 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198014921 dimer interface [polypeptide binding]; other site 264198014922 phosphorylation site [posttranslational modification] 264198014923 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198014924 ATP binding site [chemical binding]; other site 264198014925 Mg2+ binding site [ion binding]; other site 264198014926 G-X-G motif; other site 264198014927 Response regulator receiver domain; Region: Response_reg; pfam00072 264198014928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198014929 active site 264198014930 phosphorylation site [posttranslational modification] 264198014931 intermolecular recognition site; other site 264198014932 dimerization interface [polypeptide binding]; other site 264198014933 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 264198014934 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 264198014935 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198014936 dimer interface [polypeptide binding]; other site 264198014937 phosphorylation site [posttranslational modification] 264198014938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198014939 ATP binding site [chemical binding]; other site 264198014940 Mg2+ binding site [ion binding]; other site 264198014941 G-X-G motif; other site 264198014942 Response regulator receiver domain; Region: Response_reg; pfam00072 264198014943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198014944 active site 264198014945 phosphorylation site [posttranslational modification] 264198014946 intermolecular recognition site; other site 264198014947 dimerization interface [polypeptide binding]; other site 264198014948 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 264198014949 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 264198014950 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 264198014951 tetramer interface [polypeptide binding]; other site 264198014952 active site 264198014953 Mg2+/Mn2+ binding site [ion binding]; other site 264198014954 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 264198014955 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 264198014956 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 264198014957 metal ion-dependent adhesion site (MIDAS); other site 264198014958 MoxR-like ATPases [General function prediction only]; Region: COG0714 264198014959 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198014960 Walker A motif; other site 264198014961 ATP binding site [chemical binding]; other site 264198014962 Walker B motif; other site 264198014963 arginine finger; other site 264198014964 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 264198014965 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 264198014966 metal ion-dependent adhesion site (MIDAS); other site 264198014967 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 264198014968 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 264198014969 TPP-binding site [chemical binding]; other site 264198014970 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 264198014971 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 264198014972 active site 264198014973 SUMO-1 interface [polypeptide binding]; other site 264198014974 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 264198014975 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 264198014976 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 264198014977 conserved cys residue [active] 264198014978 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 264198014979 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198014980 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323 264198014981 gating phenylalanine in ion channel; other site 264198014982 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264198014983 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 264198014984 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198014985 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198014986 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 264198014987 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198014988 putative substrate translocation pore; other site 264198014989 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 264198014990 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 264198014991 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 264198014992 PYR/PP interface [polypeptide binding]; other site 264198014993 dimer interface [polypeptide binding]; other site 264198014994 TPP binding site [chemical binding]; other site 264198014995 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 264198014996 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 264198014997 TPP-binding site [chemical binding]; other site 264198014998 dimer interface [polypeptide binding]; other site 264198014999 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198015000 trimer interface [polypeptide binding]; other site 264198015001 eyelet of channel; other site 264198015002 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 264198015003 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 264198015004 Na binding site [ion binding]; other site 264198015005 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 264198015006 LysR family transcriptional regulator; Provisional; Region: PRK14997 264198015007 Helix-turn-helix domains; Region: HTH; cl00088 264198015008 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198015009 putative effector binding pocket; other site 264198015010 dimerization interface [polypeptide binding]; other site 264198015011 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 264198015012 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264198015013 P-loop; other site 264198015014 Magnesium ion binding site [ion binding]; other site 264198015015 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264198015016 Magnesium ion binding site [ion binding]; other site 264198015017 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198015018 Helix-turn-helix domains; Region: HTH; cl00088 264198015019 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198015020 NMT1-like family; Region: NMT1_2; cl15260 264198015021 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 264198015022 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 264198015023 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 264198015024 active site 264198015025 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 264198015026 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 264198015027 conserved cys residue [active] 264198015028 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 264198015029 Helix-turn-helix domains; Region: HTH; cl00088 264198015030 AsnC family; Region: AsnC_trans_reg; pfam01037 264198015031 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 264198015032 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 264198015033 dimer interface [polypeptide binding]; other site 264198015034 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 264198015035 active site 264198015036 Fe binding site [ion binding]; other site 264198015037 aromatic amino acid transporter; Provisional; Region: PRK10238 264198015038 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 264198015039 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198015040 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198015041 homodimer interface [polypeptide binding]; other site 264198015042 catalytic residue [active] 264198015043 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198015044 classical (c) SDRs; Region: SDR_c; cd05233 264198015045 NAD(P) binding site [chemical binding]; other site 264198015046 active site 264198015047 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 264198015048 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 264198015049 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 264198015050 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 264198015051 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 264198015052 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 264198015053 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 264198015054 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 264198015055 MltA-interacting protein MipA; Region: MipA; cl01504 264198015056 Protein of unknown function (DUF3175); Region: DUF3175; pfam11373 264198015057 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 264198015058 active site 264198015059 intersubunit interface [polypeptide binding]; other site 264198015060 catalytic residue [active] 264198015061 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 264198015062 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 264198015063 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 264198015064 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 264198015065 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198015066 Helix-turn-helix domains; Region: HTH; cl00088 264198015067 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198015068 Helix-turn-helix domains; Region: HTH; cl00088 264198015069 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198015070 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198015071 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198015072 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198015073 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 264198015074 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198015075 active site 264198015076 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198015077 NMT1-like family; Region: NMT1_2; cl15260 264198015078 Cupin domain; Region: Cupin_2; cl09118 264198015079 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 264198015080 putative uracil binding site [chemical binding]; other site 264198015081 putative active site [active] 264198015082 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 264198015083 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 264198015084 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 264198015085 generic binding surface II; other site 264198015086 generic binding surface I; other site 264198015087 DNA Polymerase Y-family; Region: PolY_like; cd03468 264198015088 active site 264198015089 DNA binding site [nucleotide binding] 264198015090 Cell division inhibitor SulA; Region: SulA; cl01880 264198015091 enoyl-CoA hydratase; Provisional; Region: PRK06688 264198015092 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198015093 substrate binding site [chemical binding]; other site 264198015094 oxyanion hole (OAH) forming residues; other site 264198015095 trimer interface [polypeptide binding]; other site 264198015096 Helix-turn-helix domains; Region: HTH; cl00088 264198015097 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264198015098 Transcriptional regulators [Transcription]; Region: PurR; COG1609 264198015099 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 264198015100 DNA binding site [nucleotide binding] 264198015101 domain linker motif; other site 264198015102 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287 264198015103 putative dimerization interface [polypeptide binding]; other site 264198015104 putative ligand binding site [chemical binding]; other site 264198015105 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 264198015106 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198015107 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 264198015108 active site 264198015109 xanthine permease; Region: pbuX; TIGR03173 264198015110 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 264198015111 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 264198015112 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 264198015113 putative active site [active] 264198015114 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 264198015115 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264198015116 catalytic residue [active] 264198015117 allantoate amidohydrolase; Reviewed; Region: PRK12893 264198015118 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 264198015119 active site 264198015120 metal binding site [ion binding]; metal-binding site 264198015121 dimer interface [polypeptide binding]; other site 264198015122 N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases); Region: DCase; cd07569 264198015123 Predicted amidohydrolase [General function prediction only]; Region: COG0388 264198015124 tetramer interface [polypeptide binding]; other site 264198015125 active site 264198015126 catalytic triad [active] 264198015127 dimer interface [polypeptide binding]; other site 264198015128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198015129 D-galactonate transporter; Region: 2A0114; TIGR00893 264198015130 putative substrate translocation pore; other site 264198015131 peptidase; Reviewed; Region: PRK13004 264198015132 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 264198015133 putative metal binding site [ion binding]; other site 264198015134 putative dimer interface [polypeptide binding]; other site 264198015135 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 264198015136 active site 264198015137 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 264198015138 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198015139 ATP binding site [chemical binding]; other site 264198015140 Mg2+ binding site [ion binding]; other site 264198015141 G-X-G motif; other site 264198015142 Response regulator receiver domain; Region: Response_reg; pfam00072 264198015143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198015144 active site 264198015145 phosphorylation site [posttranslational modification] 264198015146 intermolecular recognition site; other site 264198015147 dimerization interface [polypeptide binding]; other site 264198015148 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 264198015149 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198015150 dimer interface [polypeptide binding]; other site 264198015151 phosphorylation site [posttranslational modification] 264198015152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198015153 ATP binding site [chemical binding]; other site 264198015154 Mg2+ binding site [ion binding]; other site 264198015155 G-X-G motif; other site 264198015156 Response regulator receiver domain; Region: Response_reg; pfam00072 264198015157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198015158 active site 264198015159 phosphorylation site [posttranslational modification] 264198015160 intermolecular recognition site; other site 264198015161 dimerization interface [polypeptide binding]; other site 264198015162 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 264198015163 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198015164 Helix-turn-helix domains; Region: HTH; cl00088 264198015165 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 264198015166 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 264198015167 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198015168 NMT1-like family; Region: NMT1_2; cl15260 264198015169 putative amidase; Provisional; Region: PRK06169 264198015170 Amidase; Region: Amidase; cl11426 264198015171 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 264198015172 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 264198015173 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264198015174 ATP binding site [chemical binding]; other site 264198015175 putative Mg++ binding site [ion binding]; other site 264198015176 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264198015177 nucleotide binding region [chemical binding]; other site 264198015178 ATP-binding site [chemical binding]; other site 264198015179 Oxygenase domain of the 2OGFeDO superfamily; Region: Tet_JBP; pfam12851 264198015180 enoyl-CoA hydratase; Provisional; Region: PRK05981 264198015181 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198015182 substrate binding site [chemical binding]; other site 264198015183 oxyanion hole (OAH) forming residues; other site 264198015184 trimer interface [polypeptide binding]; other site 264198015185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198015186 NMT1-like family; Region: NMT1_2; cl15260 264198015187 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198015188 NMT1-like family; Region: NMT1_2; cl15260 264198015189 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198015190 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198015191 enoyl-CoA hydratase; Provisional; Region: PRK09245 264198015192 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198015193 substrate binding site [chemical binding]; other site 264198015194 oxyanion hole (OAH) forming residues; other site 264198015195 trimer interface [polypeptide binding]; other site 264198015196 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 264198015197 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 264198015198 NAD binding site [chemical binding]; other site 264198015199 homodimer interface [polypeptide binding]; other site 264198015200 homotetramer interface [polypeptide binding]; other site 264198015201 active site 264198015202 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198015203 Helix-turn-helix domains; Region: HTH; cl00088 264198015204 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 264198015205 dimerization interface [polypeptide binding]; other site 264198015206 substrate binding pocket [chemical binding]; other site 264198015207 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 264198015208 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198015209 CoA-ligase; Region: Ligase_CoA; cl02894 264198015210 ATP-grasp domain; Region: ATP-grasp_4; cl03087 264198015211 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198015212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198015213 NAD(P) binding site [chemical binding]; other site 264198015214 active site 264198015215 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 264198015216 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 264198015217 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198015218 active site 264198015219 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 264198015220 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198015221 active site 264198015222 enoyl-CoA hydratase; Provisional; Region: PRK06688 264198015223 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198015224 substrate binding site [chemical binding]; other site 264198015225 oxyanion hole (OAH) forming residues; other site 264198015226 trimer interface [polypeptide binding]; other site 264198015227 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 264198015228 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 264198015229 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264198015230 dimer interface [polypeptide binding]; other site 264198015231 active site 264198015232 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198015233 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198015234 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198015235 active site 264198015236 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198015237 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198015238 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 264198015239 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 264198015240 active site 264198015241 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 264198015242 DUF35 OB-fold domain; Region: DUF35; pfam01796 264198015243 benzoate transport; Region: 2A0115; TIGR00895 264198015244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198015245 putative substrate translocation pore; other site 264198015246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198015247 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 264198015248 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 264198015249 Sulfatase; Region: Sulfatase; cl10460 264198015250 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 264198015251 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 264198015252 dimer interface [polypeptide binding]; other site 264198015253 active site 264198015254 metal binding site [ion binding]; metal-binding site 264198015255 Cupin domain; Region: Cupin_2; cl09118 264198015256 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198015257 short chain dehydrogenase; Validated; Region: PRK07069 264198015258 NAD(P) binding site [chemical binding]; other site 264198015259 active site 264198015260 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198015261 Helix-turn-helix domain; Region: HTH_18; pfam12833 264198015262 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198015263 MFS transport protein AraJ; Provisional; Region: PRK10091 264198015264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198015265 putative substrate translocation pore; other site 264198015266 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 264198015267 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 264198015268 Subunit I/III interface [polypeptide binding]; other site 264198015269 Subunit III/IV interface [polypeptide binding]; other site 264198015270 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 264198015271 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 264198015272 D-pathway; other site 264198015273 Putative ubiquinol binding site [chemical binding]; other site 264198015274 Low-spin heme (heme b) binding site [chemical binding]; other site 264198015275 Putative water exit pathway; other site 264198015276 Binuclear center (heme o3/CuB) [ion binding]; other site 264198015277 K-pathway; other site 264198015278 Putative proton exit pathway; other site 264198015279 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 264198015280 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 264198015281 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 264198015282 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 264198015283 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198015284 DNA-binding site [nucleotide binding]; DNA binding site 264198015285 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264198015286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198015287 homodimer interface [polypeptide binding]; other site 264198015288 catalytic residue [active] 264198015289 Protein of unknown function (DUF445); Region: DUF445; pfam04286 264198015290 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 264198015291 DNA polymerase II; Reviewed; Region: PRK05762 264198015292 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 264198015293 active site 264198015294 catalytic site [active] 264198015295 substrate binding site [chemical binding]; other site 264198015296 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 264198015297 active site 264198015298 metal-binding site 264198015299 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 264198015300 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 264198015301 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 264198015302 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 264198015303 SLBB domain; Region: SLBB; pfam10531 264198015304 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 264198015305 FAD binding domain; Region: FAD_binding_2; pfam00890 264198015306 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198015307 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 264198015308 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 264198015309 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 264198015310 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 264198015311 BON domain; Region: BON; cl02771 264198015312 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 264198015313 Double zinc ribbon; Region: DZR; pfam12773 264198015314 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 264198015315 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 264198015316 cyclase homology domain; Region: CHD; cd07302 264198015317 nucleotidyl binding site; other site 264198015318 metal binding site [ion binding]; metal-binding site 264198015319 dimer interface [polypeptide binding]; other site 264198015320 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198015321 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198015322 Helix-turn-helix domains; Region: HTH; cl00088 264198015323 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 264198015324 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198015325 CoA-ligase; Region: Ligase_CoA; cl02894 264198015326 ATP-grasp domain; Region: ATP-grasp_4; cl03087 264198015327 enoyl-CoA hydratase; Provisional; Region: PRK06688 264198015328 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198015329 substrate binding site [chemical binding]; other site 264198015330 oxyanion hole (OAH) forming residues; other site 264198015331 trimer interface [polypeptide binding]; other site 264198015332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198015333 NMT1-like family; Region: NMT1_2; cl15260 264198015334 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 264198015335 Predicted permease; Region: DUF318; pfam03773 264198015336 Predicted permeases [General function prediction only]; Region: COG0701 264198015337 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264198015338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198015339 active site 264198015340 phosphorylation site [posttranslational modification] 264198015341 intermolecular recognition site; other site 264198015342 dimerization interface [polypeptide binding]; other site 264198015343 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198015344 dimer interface [polypeptide binding]; other site 264198015345 phosphorylation site [posttranslational modification] 264198015346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198015347 ATP binding site [chemical binding]; other site 264198015348 Mg2+ binding site [ion binding]; other site 264198015349 G-X-G motif; other site 264198015350 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 264198015351 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198015352 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198015353 Helix-turn-helix domains; Region: HTH; cl00088 264198015354 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264198015355 dimerization interface [polypeptide binding]; other site 264198015356 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 264198015357 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 264198015358 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 264198015359 NMT1-like family; Region: NMT1_2; cl15260 264198015360 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 264198015361 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 264198015362 cardiolipin synthase 2; Provisional; Region: PRK11263 264198015363 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 264198015364 putative active site [active] 264198015365 catalytic site [active] 264198015366 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 264198015367 putative active site [active] 264198015368 catalytic site [active] 264198015369 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198015370 NMT1-like family; Region: NMT1_2; cl15260 264198015371 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198015372 NMT1-like family; Region: NMT1_2; cl15260 264198015373 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 264198015374 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 264198015375 active site 264198015376 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 264198015377 Strictosidine synthase; Region: Str_synth; pfam03088 264198015378 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198015379 NMT1-like family; Region: NMT1_2; cl15260 264198015380 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 264198015381 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198015382 hypothetical protein; Validated; Region: PRK06201 264198015383 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 264198015384 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198015385 Helix-turn-helix domains; Region: HTH; cl00088 264198015386 Isochorismatase family; Region: Isochorismatase; pfam00857 264198015387 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 264198015388 catalytic triad [active] 264198015389 conserved cis-peptide bond; other site 264198015390 amino-acid N-acetyltransferase; Region: PLN02825 264198015391 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264198015392 Coenzyme A binding pocket [chemical binding]; other site 264198015393 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198015394 D-loop; other site 264198015395 H-loop/switch region; other site 264198015396 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 264198015397 Walker A/P-loop; other site 264198015398 ATP binding site [chemical binding]; other site 264198015399 Q-loop/lid; other site 264198015400 aromatic amino acid exporter; Provisional; Region: PRK11689 264198015401 Uncharacterized protein family (UPF0254); Region: UPF0254; cl01641 264198015402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198015403 NMT1-like family; Region: NMT1_2; cl15260 264198015404 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 264198015405 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198015406 Helix-turn-helix domains; Region: HTH; cl00088 264198015407 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198015408 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198015409 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198015410 active site 264198015411 Transcriptional regulators [Transcription]; Region: FadR; COG2186 264198015412 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198015413 DNA-binding site [nucleotide binding]; DNA binding site 264198015414 FCD domain; Region: FCD; cl11656 264198015415 Helix-turn-helix domains; Region: HTH; cl00088 264198015416 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 264198015417 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264198015418 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 264198015419 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198015420 Helix-turn-helix domains; Region: HTH; cl00088 264198015421 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 264198015422 NAD(P) binding site [chemical binding]; other site 264198015423 catalytic residues [active] 264198015424 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 264198015425 dimer interface [polypeptide binding]; other site 264198015426 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 264198015427 Helix-turn-helix domains; Region: HTH; cl00088 264198015428 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 264198015429 putative dimerization interface [polypeptide binding]; other site 264198015430 putative substrate binding pocket [chemical binding]; other site 264198015431 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 264198015432 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198015433 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198015434 NMT1-like family; Region: NMT1_2; cl15260 264198015435 Transcriptional regulators [Transcription]; Region: PurR; COG1609 264198015436 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 264198015437 DNA binding site [nucleotide binding] 264198015438 domain linker motif; other site 264198015439 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 264198015440 putative dimerization interface [polypeptide binding]; other site 264198015441 putative ligand binding site [chemical binding]; other site 264198015442 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 264198015443 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 264198015444 active site pocket [active] 264198015445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198015446 NMT1-like family; Region: NMT1_2; cl15260 264198015447 Protein of unknown function (DUF3422); Region: DUF3422; cl02073 264198015448 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 264198015449 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264198015450 N-terminal plug; other site 264198015451 ligand-binding site [chemical binding]; other site 264198015452 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 264198015453 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 264198015454 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 264198015455 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198015456 catalytic loop [active] 264198015457 iron binding site [ion binding]; other site 264198015458 4Fe-4S binding domain; Region: Fer4; cl02805 264198015459 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 264198015460 [4Fe-4S] binding site [ion binding]; other site 264198015461 molybdopterin cofactor binding site; other site 264198015462 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 264198015463 molybdopterin cofactor binding site; other site 264198015464 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 264198015465 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082 264198015466 putative dimer interface [polypeptide binding]; other site 264198015467 [2Fe-2S] cluster binding site [ion binding]; other site 264198015468 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 264198015469 SLBB domain; Region: SLBB; pfam10531 264198015470 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 264198015471 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 264198015472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198015473 putative substrate translocation pore; other site 264198015474 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198015475 Helix-turn-helix domains; Region: HTH; cl00088 264198015476 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 264198015477 putative dimerization interface [polypeptide binding]; other site 264198015478 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 264198015479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198015480 putative substrate translocation pore; other site 264198015481 Helix-turn-helix domains; Region: HTH; cl00088 264198015482 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 264198015483 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 264198015484 putative dimerization interface [polypeptide binding]; other site 264198015485 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 264198015486 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264198015487 N-terminal plug; other site 264198015488 ligand-binding site [chemical binding]; other site 264198015489 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 264198015490 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 264198015491 Esterase/lipase [General function prediction only]; Region: COG1647 264198015492 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198015493 PAS domain; Region: PAS_9; pfam13426 264198015494 putative active site [active] 264198015495 heme pocket [chemical binding]; other site 264198015496 formyl-coenzyme A transferase; Provisional; Region: PRK05398 264198015497 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198015498 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 264198015499 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 264198015500 PYR/PP interface [polypeptide binding]; other site 264198015501 dimer interface [polypeptide binding]; other site 264198015502 TPP binding site [chemical binding]; other site 264198015503 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 264198015504 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 264198015505 TPP-binding site; other site 264198015506 dimer interface [polypeptide binding]; other site 264198015507 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 264198015508 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 264198015509 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 264198015510 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 264198015511 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 264198015512 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198015513 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 264198015514 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 264198015515 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 264198015516 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 264198015517 formyl-coenzyme A transferase; Provisional; Region: PRK05398 264198015518 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198015519 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264198015520 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198015521 DNA-binding site [nucleotide binding]; DNA binding site 264198015522 FCD domain; Region: FCD; cl11656 264198015523 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 264198015524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198015525 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 264198015526 Integral membrane protein TerC family; Region: TerC; cl10468 264198015527 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 264198015528 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 264198015529 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264198015530 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198015531 DNA-binding site [nucleotide binding]; DNA binding site 264198015532 FCD domain; Region: FCD; cl11656 264198015533 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 264198015534 EamA-like transporter family; Region: EamA; cl01037 264198015535 N-terminal domain of MhqB, a type I extradiol dioxygenase, and similar proteins; Region: MhqB_like_N; cd08344 264198015536 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198015537 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 264198015538 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198015539 putative active site [active] 264198015540 putative metal binding site [ion binding]; other site 264198015541 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 264198015542 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 264198015543 FAD binding domain; Region: FAD_binding_3; pfam01494 264198015544 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198015545 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198015546 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 264198015547 DNA-binding site [nucleotide binding]; DNA binding site 264198015548 FCD domain; Region: FCD; cl11656 264198015549 Isochorismatase family; Region: Isochorismatase; pfam00857 264198015550 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 264198015551 catalytic triad [active] 264198015552 dimer interface [polypeptide binding]; other site 264198015553 conserved cis-peptide bond; other site 264198015554 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 264198015555 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 264198015556 dimer interface [polypeptide binding]; other site 264198015557 TPP-binding site [chemical binding]; other site 264198015558 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 264198015559 transcriptional activator TtdR; Provisional; Region: PRK09801 264198015560 Helix-turn-helix domains; Region: HTH; cl00088 264198015561 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198015562 putative effector binding pocket; other site 264198015563 dimerization interface [polypeptide binding]; other site 264198015564 LysR family transcriptional regulator; Provisional; Region: PRK14997 264198015565 Helix-turn-helix domains; Region: HTH; cl00088 264198015566 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 264198015567 putative effector binding pocket; other site 264198015568 putative dimerization interface [polypeptide binding]; other site 264198015569 Pirin-related protein [General function prediction only]; Region: COG1741 264198015570 Cupin domain; Region: Cupin_2; cl09118 264198015571 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 264198015572 Isochorismatase family; Region: Isochorismatase; pfam00857 264198015573 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 264198015574 catalytic triad [active] 264198015575 dimer interface [polypeptide binding]; other site 264198015576 conserved cis-peptide bond; other site 264198015577 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 264198015578 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 264198015579 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 264198015580 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 264198015581 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 264198015582 YCII-related domain; Region: YCII; cl00999 264198015583 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 264198015584 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 264198015585 active site 264198015586 dimer interface [polypeptide binding]; other site 264198015587 metal binding site [ion binding]; metal-binding site 264198015588 Predicted esterase [General function prediction only]; Region: COG0400 264198015589 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198015590 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 264198015591 Zn binding site [ion binding]; other site 264198015592 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 264198015593 Zn binding site [ion binding]; other site 264198015594 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 264198015595 active site 264198015596 oxalacetate binding site [chemical binding]; other site 264198015597 citrylCoA binding site [chemical binding]; other site 264198015598 coenzyme A binding site [chemical binding]; other site 264198015599 catalytic triad [active] 264198015600 acyl-CoA synthetase; Validated; Region: PRK06188 264198015601 AMP-binding enzyme; Region: AMP-binding; cl15778 264198015602 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198015603 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 264198015604 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198015605 DNA-binding site [nucleotide binding]; DNA binding site 264198015606 UTRA domain; Region: UTRA; cl01230 264198015607 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 264198015608 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 264198015609 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 264198015610 thymidine phosphorylase; Provisional; Region: PRK04350 264198015611 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 264198015612 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 264198015613 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 264198015614 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198015615 Ligand Binding Site [chemical binding]; other site 264198015616 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198015617 Ligand Binding Site [chemical binding]; other site 264198015618 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198015619 Ligand Binding Site [chemical binding]; other site 264198015620 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 264198015621 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 264198015622 putative NAD(P) binding site [chemical binding]; other site 264198015623 putative substrate binding site [chemical binding]; other site 264198015624 catalytic Zn binding site [ion binding]; other site 264198015625 structural Zn binding site [ion binding]; other site 264198015626 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198015627 active site 264198015628 I-site; other site 264198015629 metal binding site [ion binding]; metal-binding site 264198015630 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 264198015631 Sulfatase; Region: Sulfatase; cl10460 264198015632 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198015633 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198015634 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 264198015635 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 264198015636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198015637 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198015638 putative substrate translocation pore; other site 264198015639 pyruvate carboxylase; Reviewed; Region: PRK12999 264198015640 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264198015641 ATP-grasp domain; Region: ATP-grasp_4; cl03087 264198015642 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 264198015643 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 264198015644 active site 264198015645 catalytic residues [active] 264198015646 metal binding site [ion binding]; metal-binding site 264198015647 homodimer binding site [polypeptide binding]; other site 264198015648 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264198015649 carboxyltransferase (CT) interaction site; other site 264198015650 biotinylation site [posttranslational modification]; other site 264198015651 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198015652 Helix-turn-helix domains; Region: HTH; cl00088 264198015653 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 264198015654 substrate binding pocket [chemical binding]; other site 264198015655 dimerization interface [polypeptide binding]; other site 264198015656 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 264198015657 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 264198015658 iron-sulfur cluster [ion binding]; other site 264198015659 [2Fe-2S] cluster binding site [ion binding]; other site 264198015660 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 264198015661 putative alpha subunit interface [polypeptide binding]; other site 264198015662 putative active site [active] 264198015663 putative substrate binding site [chemical binding]; other site 264198015664 Fe binding site [ion binding]; other site 264198015665 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 264198015666 inter-subunit interface; other site 264198015667 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 264198015668 [2Fe-2S] cluster binding site [ion binding]; other site 264198015669 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 264198015670 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 264198015671 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198015672 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 264198015673 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 264198015674 putative catalytic residue [active] 264198015675 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198015676 Helix-turn-helix domains; Region: HTH; cl00088 264198015677 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 264198015678 classical (c) SDR, subgroup 10; Region: SDR_c10; cd05373 264198015679 putative NAD(P) binding site [chemical binding]; other site 264198015680 active site 264198015681 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 264198015682 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 264198015683 HSP70 interaction site [polypeptide binding]; other site 264198015684 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 264198015685 Zn binding sites [ion binding]; other site 264198015686 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 264198015687 dimer interface [polypeptide binding]; other site 264198015688 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 264198015689 Isochorismatase family; Region: Isochorismatase; pfam00857 264198015690 catalytic triad [active] 264198015691 dimer interface [polypeptide binding]; other site 264198015692 conserved cis-peptide bond; other site 264198015693 transcriptional regulator; Provisional; Region: PRK10632 264198015694 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 264198015695 putative effector binding pocket; other site 264198015696 putative dimerization interface [polypeptide binding]; other site 264198015697 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 264198015698 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 264198015699 putative C-terminal domain interface [polypeptide binding]; other site 264198015700 putative GSH binding site (G-site) [chemical binding]; other site 264198015701 putative dimer interface [polypeptide binding]; other site 264198015702 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 264198015703 putative N-terminal domain interface [polypeptide binding]; other site 264198015704 putative dimer interface [polypeptide binding]; other site 264198015705 putative substrate binding pocket (H-site) [chemical binding]; other site 264198015706 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 264198015707 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 264198015708 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198015709 Helix-turn-helix domains; Region: HTH; cl00088 264198015710 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198015711 dimerization interface [polypeptide binding]; other site 264198015712 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 264198015713 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 264198015714 putative NAD(P) binding site [chemical binding]; other site 264198015715 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198015716 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 264198015717 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 264198015718 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 264198015719 DNA binding site [nucleotide binding] 264198015720 active site 264198015721 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 264198015722 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 264198015723 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 264198015724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198015725 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 264198015726 putative acyltransferase; Provisional; Region: PRK05790 264198015727 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264198015728 dimer interface [polypeptide binding]; other site 264198015729 active site 264198015730 OsmC-like protein; Region: OsmC; cl00767 264198015731 putative cation:proton antiport protein; Provisional; Region: PRK10669 264198015732 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 264198015733 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198015734 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 264198015735 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 264198015736 dimer interface [polypeptide binding]; other site 264198015737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198015738 catalytic residue [active] 264198015739 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198015740 Ligand Binding Site [chemical binding]; other site 264198015741 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198015742 Ligand Binding Site [chemical binding]; other site 264198015743 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 264198015744 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198015745 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 264198015746 L-serine binding site [chemical binding]; other site 264198015747 ACT domain interface; other site 264198015748 choline dehydrogenase; Validated; Region: PRK02106 264198015749 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198015750 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 264198015751 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 264198015752 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198015753 NAD binding site [chemical binding]; other site 264198015754 catalytic residues [active] 264198015755 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 264198015756 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 264198015757 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198015758 NMT1-like family; Region: NMT1_2; cl15260 264198015759 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198015760 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198015761 active site 264198015762 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 264198015763 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198015764 NAD(P) binding site [chemical binding]; other site 264198015765 active site 264198015766 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 264198015767 active site 264198015768 catalytic site [active] 264198015769 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 264198015770 active site 264198015771 catalytic site [active] 264198015772 lipid-transfer protein; Provisional; Region: PRK08256 264198015773 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 264198015774 active site 264198015775 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 264198015776 AMP-binding enzyme; Region: AMP-binding; cl15778 264198015777 AMP-binding enzyme; Region: AMP-binding; cl15778 264198015778 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 264198015779 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198015780 DNA binding residues [nucleotide binding] 264198015781 dimerization interface [polypeptide binding]; other site 264198015782 Periplasmic nitrate reductase protein NapE; Region: NapE; cl01848 264198015783 NapD protein; Region: NapD; cl01163 264198015784 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 264198015785 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 264198015786 [4Fe-4S] binding site [ion binding]; other site 264198015787 molybdopterin cofactor binding site; other site 264198015788 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 264198015789 molybdopterin cofactor binding site; other site 264198015790 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153 264198015791 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 264198015792 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 264198015793 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198015794 Walker A/P-loop; other site 264198015795 ATP binding site [chemical binding]; other site 264198015796 Q-loop/lid; other site 264198015797 ABC transporter signature motif; other site 264198015798 Walker B; other site 264198015799 D-loop; other site 264198015800 H-loop/switch region; other site 264198015801 CcmB protein; Region: CcmB; cl01016 264198015802 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 264198015803 CcmE; Region: CcmE; cl00994 264198015804 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 264198015805 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 264198015806 catalytic residues [active] 264198015807 central insert; other site 264198015808 Cytochrome C biogenesis protein; Region: CcmH; cl01179 264198015809 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 264198015810 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 264198015811 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 264198015812 Helix-turn-helix domains; Region: HTH; cl00088 264198015813 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 264198015814 dimerization interface [polypeptide binding]; other site 264198015815 substrate binding pocket [chemical binding]; other site 264198015816 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198015817 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198015818 NAD(P) binding site [chemical binding]; other site 264198015819 active site 264198015820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198015821 D-galactonate transporter; Region: 2A0114; TIGR00893 264198015822 putative substrate translocation pore; other site 264198015823 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 264198015824 TPP-binding site [chemical binding]; other site 264198015825 dimer interface [polypeptide binding]; other site 264198015826 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 264198015827 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 264198015828 PYR/PP interface [polypeptide binding]; other site 264198015829 dimer interface [polypeptide binding]; other site 264198015830 TPP binding site [chemical binding]; other site 264198015831 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 264198015832 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 264198015833 CoenzymeA binding site [chemical binding]; other site 264198015834 subunit interaction site [polypeptide binding]; other site 264198015835 PHB binding site; other site 264198015836 enoyl-CoA hydratase; Provisional; Region: PRK06127 264198015837 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198015838 substrate binding site [chemical binding]; other site 264198015839 oxyanion hole (OAH) forming residues; other site 264198015840 trimer interface [polypeptide binding]; other site 264198015841 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 264198015842 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 264198015843 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 264198015844 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 3-O-Methylgallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of 3-O-Methylgallate; Region: 3MGA_Dioxygenase; cd07366 264198015845 putative active site [active] 264198015846 putative Fe(II) binding site [ion binding]; other site 264198015847 putative dimer interface [polypeptide binding]; other site 264198015848 putative tetramer interface [polypeptide binding]; other site 264198015849 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198015850 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198015851 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 264198015852 DUF35 OB-fold domain; Region: DUF35; pfam01796 264198015853 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 264198015854 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 264198015855 active site 264198015856 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198015857 NMT1-like family; Region: NMT1_2; cl15260 264198015858 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 264198015859 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198015860 active site 264198015861 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 264198015862 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198015863 active site 264198015864 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 264198015865 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198015866 CoA-ligase; Region: Ligase_CoA; cl02894 264198015867 ATP-grasp domain; Region: ATP-grasp_4; cl03087 264198015868 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264198015869 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198015870 DNA-binding site [nucleotide binding]; DNA binding site 264198015871 FCD domain; Region: FCD; cl11656 264198015872 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 264198015873 homotrimer interaction site [polypeptide binding]; other site 264198015874 putative active site [active] 264198015875 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198015876 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 264198015877 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 264198015878 alpha subunit interface [polypeptide binding]; other site 264198015879 active site 264198015880 substrate binding site [chemical binding]; other site 264198015881 Fe binding site [ion binding]; other site 264198015882 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198015883 NMT1-like family; Region: NMT1_2; cl15260 264198015884 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 264198015885 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 264198015886 FMN-binding pocket [chemical binding]; other site 264198015887 flavin binding motif; other site 264198015888 phosphate binding motif [ion binding]; other site 264198015889 beta-alpha-beta structure motif; other site 264198015890 NAD binding pocket [chemical binding]; other site 264198015891 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198015892 catalytic loop [active] 264198015893 iron binding site [ion binding]; other site 264198015894 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 264198015895 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198015896 substrate binding site [chemical binding]; other site 264198015897 oxyanion hole (OAH) forming residues; other site 264198015898 trimer interface [polypeptide binding]; other site 264198015899 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 264198015900 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198015901 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 264198015902 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 264198015903 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198015904 trimer interface [polypeptide binding]; other site 264198015905 eyelet of channel; other site 264198015906 Transcriptional regulators [Transcription]; Region: FadR; COG2186 264198015907 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198015908 DNA-binding site [nucleotide binding]; DNA binding site 264198015909 FCD domain; Region: FCD; cl11656 264198015910 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 264198015911 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 264198015912 NAD binding site [chemical binding]; other site 264198015913 homodimer interface [polypeptide binding]; other site 264198015914 active site 264198015915 putative substrate binding site [chemical binding]; other site 264198015916 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 264198015917 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 264198015918 substrate-cofactor binding pocket; other site 264198015919 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198015920 catalytic residue [active] 264198015921 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 264198015922 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264198015923 sequence-specific DNA binding site [nucleotide binding]; other site 264198015924 salt bridge; other site 264198015925 Cupin domain; Region: Cupin_2; cl09118 264198015926 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 264198015927 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 264198015928 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 264198015929 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 264198015930 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 264198015931 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 264198015932 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 264198015933 dimerization interface [polypeptide binding]; other site 264198015934 ligand binding site [chemical binding]; other site 264198015935 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 264198015936 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 264198015937 conserved cys residue [active] 264198015938 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198015939 dimer interface [polypeptide binding]; other site 264198015940 conserved gate region; other site 264198015941 putative PBP binding loops; other site 264198015942 ABC-ATPase subunit interface; other site 264198015943 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 264198015944 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 264198015945 Walker A/P-loop; other site 264198015946 ATP binding site [chemical binding]; other site 264198015947 Q-loop/lid; other site 264198015948 ABC transporter signature motif; other site 264198015949 Walker B; other site 264198015950 D-loop; other site 264198015951 H-loop/switch region; other site 264198015952 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 264198015953 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 264198015954 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 264198015955 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 264198015956 putative active site [active] 264198015957 putative substrate binding site [chemical binding]; other site 264198015958 putative cosubstrate binding site; other site 264198015959 catalytic site [active] 264198015960 NMT1-like family; Region: NMT1_2; cl15260 264198015961 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 264198015962 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 264198015963 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 264198015964 FAD binding pocket [chemical binding]; other site 264198015965 FAD binding motif [chemical binding]; other site 264198015966 phosphate binding motif [ion binding]; other site 264198015967 beta-alpha-beta structure motif; other site 264198015968 NAD binding pocket [chemical binding]; other site 264198015969 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198015970 catalytic loop [active] 264198015971 iron binding site [ion binding]; other site 264198015972 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 264198015973 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 264198015974 [2Fe-2S] cluster binding site [ion binding]; other site 264198015975 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 264198015976 putative alpha subunit interface [polypeptide binding]; other site 264198015977 putative active site [active] 264198015978 putative substrate binding site [chemical binding]; other site 264198015979 Fe binding site [ion binding]; other site 264198015980 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 264198015981 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 264198015982 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 264198015983 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 264198015984 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 264198015985 Cysteine-rich domain; Region: CCG; pfam02754 264198015986 Cysteine-rich domain; Region: CCG; pfam02754 264198015987 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 264198015988 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 264198015989 putative active site [active] 264198015990 putative FMN binding site [chemical binding]; other site 264198015991 putative substrate binding site [chemical binding]; other site 264198015992 putative catalytic residue [active] 264198015993 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198015994 Heme NO binding; Region: HNOB; cl15268 264198015995 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 264198015996 active site 264198015997 dimer interface [polypeptide binding]; other site 264198015998 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 264198015999 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 264198016000 dimer interface [polypeptide binding]; other site 264198016001 active site 264198016002 glycine-pyridoxal phosphate binding site [chemical binding]; other site 264198016003 folate binding site [chemical binding]; other site 264198016004 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 264198016005 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 264198016006 conserved cys residue [active] 264198016007 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 264198016008 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 264198016009 NAD binding site [chemical binding]; other site 264198016010 catalytic Zn binding site [ion binding]; other site 264198016011 structural Zn binding site [ion binding]; other site 264198016012 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198016013 trimer interface [polypeptide binding]; other site 264198016014 eyelet of channel; other site 264198016015 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 264198016016 active site 264198016017 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 264198016018 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 264198016019 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 264198016020 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 264198016021 Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767 264198016022 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 264198016023 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198016024 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 264198016025 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 264198016026 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 264198016027 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 264198016028 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 264198016029 conserved cys residue [active] 264198016030 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198016031 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 264198016032 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 264198016033 substrate binding site [chemical binding]; other site 264198016034 catalytic Zn binding site [ion binding]; other site 264198016035 NAD binding site [chemical binding]; other site 264198016036 structural Zn binding site [ion binding]; other site 264198016037 dimer interface [polypeptide binding]; other site 264198016038 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 264198016039 Double zinc ribbon; Region: DZR; pfam12773 264198016040 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 264198016041 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 264198016042 cyclase homology domain; Region: CHD; cd07302 264198016043 nucleotidyl binding site; other site 264198016044 metal binding site [ion binding]; metal-binding site 264198016045 dimer interface [polypeptide binding]; other site 264198016046 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198016047 Flavin Reductases; Region: FlaRed; cl00801 264198016048 Helix-turn-helix domains; Region: HTH; cl00088 264198016049 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 264198016050 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 264198016051 putative dimerization interface [polypeptide binding]; other site 264198016052 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 264198016053 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 264198016054 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198016055 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 264198016056 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198016057 DNA-binding site [nucleotide binding]; DNA binding site 264198016058 UTRA domain; Region: UTRA; cl01230 264198016059 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 264198016060 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 264198016061 tetramer interface [polypeptide binding]; other site 264198016062 active site 264198016063 Mg2+/Mn2+ binding site [ion binding]; other site 264198016064 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 264198016065 substrate binding site [chemical binding]; other site 264198016066 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 264198016067 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 264198016068 substrate binding site [chemical binding]; other site 264198016069 ligand binding site [chemical binding]; other site 264198016070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198016071 NMT1-like family; Region: NMT1_2; cl15260 264198016072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198016073 putative substrate translocation pore; other site 264198016074 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198016075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198016076 putative substrate translocation pore; other site 264198016077 Helix-turn-helix domains; Region: HTH; cl00088 264198016078 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 264198016079 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198016080 dimerization interface [polypeptide binding]; other site 264198016081 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 264198016082 Isochorismatase family; Region: Isochorismatase; pfam00857 264198016083 catalytic triad [active] 264198016084 dimer interface [polypeptide binding]; other site 264198016085 conserved cis-peptide bond; other site 264198016086 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 264198016087 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 264198016088 active site 264198016089 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 264198016090 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 264198016091 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 264198016092 cyclase homology domain; Region: CHD; cd07302 264198016093 nucleotidyl binding site; other site 264198016094 metal binding site [ion binding]; metal-binding site 264198016095 dimer interface [polypeptide binding]; other site 264198016096 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 264198016097 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198016098 classical (c) SDRs; Region: SDR_c; cd05233 264198016099 NAD(P) binding site [chemical binding]; other site 264198016100 active site 264198016101 threonine and homoserine efflux system; Provisional; Region: PRK10532 264198016102 NMT1-like family; Region: NMT1_2; cl15260 264198016103 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 264198016104 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 264198016105 Helix-turn-helix domains; Region: HTH; cl00088 264198016106 nitrate transmembrane transporter; Provisional; Region: PLN00028 264198016107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198016108 nitrite reductase subunit NirD; Provisional; Region: PRK14989 264198016109 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198016110 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 264198016111 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 264198016112 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 264198016113 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 264198016114 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 264198016115 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 264198016116 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 264198016117 [4Fe-4S] binding site [ion binding]; other site 264198016118 molybdopterin cofactor binding site; other site 264198016119 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 264198016120 molybdopterin cofactor binding site; other site 264198016121 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 264198016122 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 264198016123 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198016124 metal binding site [ion binding]; metal-binding site 264198016125 active site 264198016126 I-site; other site 264198016127 putative transporter; Provisional; Region: PRK10504 264198016128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198016129 putative substrate translocation pore; other site 264198016130 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264198016131 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 264198016132 N-terminal plug; other site 264198016133 ligand-binding site [chemical binding]; other site 264198016134 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 264198016135 feruloyl-CoA synthase; Reviewed; Region: PRK08180 264198016136 AMP-binding enzyme; Region: AMP-binding; cl15778 264198016137 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198016138 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 264198016139 NAD(P) binding site [chemical binding]; other site 264198016140 catalytic residues [active] 264198016141 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 264198016142 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198016143 substrate binding site [chemical binding]; other site 264198016144 oxyanion hole (OAH) forming residues; other site 264198016145 trimer interface [polypeptide binding]; other site 264198016146 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198016147 trimer interface [polypeptide binding]; other site 264198016148 eyelet of channel; other site 264198016149 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 264198016150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198016151 putative substrate translocation pore; other site 264198016152 Tannase and feruloyl esterase; Region: Tannase; pfam07519 264198016153 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264198016154 Helix-turn-helix domains; Region: HTH; cl00088 264198016155 Transglycosylase; Region: Transgly; cl07896 264198016156 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 264198016157 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 264198016158 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198016159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 264198016160 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 264198016161 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 264198016162 EamA-like transporter family; Region: EamA; cl01037 264198016163 Cupin domain; Region: Cupin_2; cl09118 264198016164 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198016165 allophanate hydrolase; Provisional; Region: PRK08186 264198016166 Amidase; Region: Amidase; cl11426 264198016167 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 264198016168 urea carboxylase; Region: urea_carbox; TIGR02712 264198016169 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264198016170 ATP-grasp domain; Region: ATP-grasp_4; cl03087 264198016171 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 264198016172 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 264198016173 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 264198016174 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264198016175 carboxyltransferase (CT) interaction site; other site 264198016176 biotinylation site [posttranslational modification]; other site 264198016177 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 264198016178 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 264198016179 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 264198016180 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 264198016181 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 264198016182 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 264198016183 Walker A/P-loop; other site 264198016184 ATP binding site [chemical binding]; other site 264198016185 Q-loop/lid; other site 264198016186 ABC transporter signature motif; other site 264198016187 Walker B; other site 264198016188 D-loop; other site 264198016189 H-loop/switch region; other site 264198016190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198016191 dimer interface [polypeptide binding]; other site 264198016192 conserved gate region; other site 264198016193 putative PBP binding loops; other site 264198016194 ABC-ATPase subunit interface; other site 264198016195 NMT1-like family; Region: NMT1_2; cl15260 264198016196 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 264198016197 metabolite-proton symporter; Region: 2A0106; TIGR00883 264198016198 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 264198016199 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 264198016200 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 264198016201 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 264198016202 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 264198016203 D-pathway; other site 264198016204 Putative ubiquinol binding site [chemical binding]; other site 264198016205 Low-spin heme (heme b) binding site [chemical binding]; other site 264198016206 Putative water exit pathway; other site 264198016207 Binuclear center (heme o3/CuB) [ion binding]; other site 264198016208 K-pathway; other site 264198016209 Putative proton exit pathway; other site 264198016210 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 264198016211 Subunit I/III interface [polypeptide binding]; other site 264198016212 Subunit III/IV interface [polypeptide binding]; other site 264198016213 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 264198016214 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 264198016215 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 264198016216 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264198016217 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 264198016218 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 264198016219 putative NADP binding site [chemical binding]; other site 264198016220 putative substrate binding site [chemical binding]; other site 264198016221 active site 264198016222 LytB protein; Region: LYTB; cl00507 264198016223 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 264198016224 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 264198016225 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264198016226 FeS/SAM binding site; other site 264198016227 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 264198016228 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 264198016229 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 264198016230 ligand binding site; other site 264198016231 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 264198016232 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 264198016233 B12 binding site [chemical binding]; other site 264198016234 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264198016235 FeS/SAM binding site; other site 264198016236 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 264198016237 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 264198016238 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 264198016239 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 264198016240 VacJ like lipoprotein; Region: VacJ; cl01073 264198016241 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 264198016242 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 264198016243 threonine dehydratase; Reviewed; Region: PRK09224 264198016244 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 264198016245 tetramer interface [polypeptide binding]; other site 264198016246 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198016247 catalytic residue [active] 264198016248 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 264198016249 putative Ile/Val binding site [chemical binding]; other site 264198016250 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 264198016251 putative Ile/Val binding site [chemical binding]; other site 264198016252 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 264198016253 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 264198016254 catalytic residues [active] 264198016255 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 264198016256 DNA-binding interface [nucleotide binding]; DNA binding site 264198016257 CheB methylesterase; Region: CheB_methylest; pfam01339 264198016258 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 264198016259 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 264198016260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 264198016261 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 264198016262 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 264198016263 PAS domain; Region: PAS_10; pfam13596 264198016264 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198016265 putative active site [active] 264198016266 heme pocket [chemical binding]; other site 264198016267 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 264198016268 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198016269 putative active site [active] 264198016270 heme pocket [chemical binding]; other site 264198016271 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198016272 dimer interface [polypeptide binding]; other site 264198016273 phosphorylation site [posttranslational modification] 264198016274 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198016275 ATP binding site [chemical binding]; other site 264198016276 Mg2+ binding site [ion binding]; other site 264198016277 G-X-G motif; other site 264198016278 Response regulator receiver domain; Region: Response_reg; pfam00072 264198016279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198016280 active site 264198016281 phosphorylation site [posttranslational modification] 264198016282 intermolecular recognition site; other site 264198016283 dimerization interface [polypeptide binding]; other site 264198016284 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 264198016285 Erythromycin esterase; Region: Erythro_esteras; pfam05139 264198016286 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 264198016287 Domain of unknown function (DUF305); Region: DUF305; cl15795 264198016288 Phasin protein; Region: Phasin_2; cl11491 264198016289 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198016290 Helix-turn-helix domains; Region: HTH; cl00088 264198016291 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 264198016292 putative dimerization interface [polypeptide binding]; other site 264198016293 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 264198016294 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 264198016295 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 264198016296 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 264198016297 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 264198016298 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 264198016299 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; cl07913 264198016300 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 264198016301 Acyl transferase domain; Region: Acyl_transf_1; cl08282 264198016302 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 264198016303 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264198016304 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 264198016305 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198016306 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 264198016307 Helix-turn-helix domains; Region: HTH; cl00088 264198016308 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198016309 Methyltransferase domain; Region: Methyltransf_31; pfam13847 264198016310 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198016311 S-adenosylmethionine binding site [chemical binding]; other site 264198016312 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264198016313 active site 264198016314 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 264198016315 CoenzymeA binding site [chemical binding]; other site 264198016316 subunit interaction site [polypeptide binding]; other site 264198016317 PHB binding site; other site 264198016318 CHASE2 domain; Region: CHASE2; cl01732 264198016319 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 264198016320 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198016321 dimer interface [polypeptide binding]; other site 264198016322 phosphorylation site [posttranslational modification] 264198016323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198016324 ATP binding site [chemical binding]; other site 264198016325 Mg2+ binding site [ion binding]; other site 264198016326 G-X-G motif; other site 264198016327 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 264198016328 FecR protein; Region: FecR; pfam04773 264198016329 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264198016330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198016331 active site 264198016332 phosphorylation site [posttranslational modification] 264198016333 intermolecular recognition site; other site 264198016334 dimerization interface [polypeptide binding]; other site 264198016335 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198016336 DNA binding site [nucleotide binding] 264198016337 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 264198016338 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u2; cd10926 264198016339 putative active site [active] 264198016340 Predicted acyltransferase [General function prediction only]; Region: COG4801 264198016341 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 264198016342 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 264198016343 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 264198016344 DXD motif; other site 264198016345 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 264198016346 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 264198016347 active site 264198016348 homodimer interface [polypeptide binding]; other site 264198016349 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 264198016350 DNA-binding site [nucleotide binding]; DNA binding site 264198016351 RNA-binding motif; other site 264198016352 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 264198016353 active site lid residues [active] 264198016354 substrate binding pocket [chemical binding]; other site 264198016355 catalytic residues [active] 264198016356 substrate-Mg2+ binding site; other site 264198016357 aspartate-rich region 1; other site 264198016358 aspartate-rich region 2; other site 264198016359 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 264198016360 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 264198016361 Active site cavity [active] 264198016362 catalytic acid [active] 264198016363 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 264198016364 putative chaperone; Provisional; Region: PRK11678 264198016365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198016366 NMT1-like family; Region: NMT1_2; cl15260 264198016367 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198016368 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198016369 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 264198016370 active site 264198016371 citrylCoA binding site [chemical binding]; other site 264198016372 oxalacetate binding site [chemical binding]; other site 264198016373 coenzyme A binding site [chemical binding]; other site 264198016374 catalytic triad [active] 264198016375 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198016376 metal binding site [ion binding]; metal-binding site 264198016377 active site 264198016378 I-site; other site 264198016379 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198016380 Helix-turn-helix domains; Region: HTH; cl00088 264198016381 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198016382 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 264198016383 Helix-turn-helix domains; Region: HTH; cl00088 264198016384 Methyltransferase domain; Region: Methyltransf_31; pfam13847 264198016385 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198016386 S-adenosylmethionine binding site [chemical binding]; other site 264198016387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 264198016388 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 264198016389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198016390 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 264198016391 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 264198016392 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 264198016393 homodimer interface [polypeptide binding]; other site 264198016394 substrate-cofactor binding pocket; other site 264198016395 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198016396 catalytic residue [active] 264198016397 NMT1-like family; Region: NMT1_2; cl15260 264198016398 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 264198016399 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 264198016400 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 264198016401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 264198016402 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 264198016403 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 264198016404 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 264198016405 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 264198016406 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198016407 dimer interface [polypeptide binding]; other site 264198016408 phosphorylation site [posttranslational modification] 264198016409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198016410 ATP binding site [chemical binding]; other site 264198016411 Mg2+ binding site [ion binding]; other site 264198016412 G-X-G motif; other site 264198016413 Response regulator receiver domain; Region: Response_reg; pfam00072 264198016414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198016415 active site 264198016416 phosphorylation site [posttranslational modification] 264198016417 intermolecular recognition site; other site 264198016418 dimerization interface [polypeptide binding]; other site 264198016419 PAS domain S-box; Region: sensory_box; TIGR00229 264198016420 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198016421 putative active site [active] 264198016422 heme pocket [chemical binding]; other site 264198016423 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198016424 dimer interface [polypeptide binding]; other site 264198016425 phosphorylation site [posttranslational modification] 264198016426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198016427 ATP binding site [chemical binding]; other site 264198016428 Mg2+ binding site [ion binding]; other site 264198016429 G-X-G motif; other site 264198016430 Response regulator receiver domain; Region: Response_reg; pfam00072 264198016431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198016432 active site 264198016433 phosphorylation site [posttranslational modification] 264198016434 intermolecular recognition site; other site 264198016435 dimerization interface [polypeptide binding]; other site 264198016436 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 264198016437 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 264198016438 tetramer interface [polypeptide binding]; other site 264198016439 TPP-binding site [chemical binding]; other site 264198016440 heterodimer interface [polypeptide binding]; other site 264198016441 phosphorylation loop region [posttranslational modification] 264198016442 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 264198016443 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 264198016444 alpha subunit interface [polypeptide binding]; other site 264198016445 TPP binding site [chemical binding]; other site 264198016446 heterodimer interface [polypeptide binding]; other site 264198016447 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 264198016448 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 264198016449 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 264198016450 E3 interaction surface; other site 264198016451 lipoyl attachment site [posttranslational modification]; other site 264198016452 e3 binding domain; Region: E3_binding; pfam02817 264198016453 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 264198016454 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 264198016455 putative active site [active] 264198016456 catalytic site [active] 264198016457 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 264198016458 putative active site [active] 264198016459 catalytic site [active] 264198016460 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 264198016461 Sulfate transporter family; Region: Sulfate_transp; cl15842 264198016462 Sulfate transporter family; Region: Sulfate_transp; cl15842 264198016463 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 264198016464 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198016465 Ligand Binding Site [chemical binding]; other site 264198016466 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 264198016467 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 264198016468 dimer interface [polypeptide binding]; other site 264198016469 decamer (pentamer of dimers) interface [polypeptide binding]; other site 264198016470 catalytic triad [active] 264198016471 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 264198016472 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 264198016473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198016474 active site 264198016475 phosphorylation site [posttranslational modification] 264198016476 intermolecular recognition site; other site 264198016477 dimerization interface [polypeptide binding]; other site 264198016478 Ubiquitin-like proteins; Region: UBQ; cl00155 264198016479 charged pocket; other site 264198016480 hydrophobic patch; other site 264198016481 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 264198016482 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 264198016483 Sulfate transporter family; Region: Sulfate_transp; cl15842 264198016484 H-NS histone family; Region: Histone_HNS; pfam00816 264198016485 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 264198016486 Helix-turn-helix domains; Region: HTH; cl00088 264198016487 transcriptional activator TtdR; Provisional; Region: PRK09801 264198016488 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198016489 putative effector binding pocket; other site 264198016490 dimerization interface [polypeptide binding]; other site 264198016491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198016492 MFS transport protein AraJ; Provisional; Region: PRK10091 264198016493 putative substrate translocation pore; other site 264198016494 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264198016495 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 264198016496 active site 264198016497 nucleotide binding site [chemical binding]; other site 264198016498 HIGH motif; other site 264198016499 KMSKS motif; other site 264198016500 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198016501 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 264198016502 LicD family; Region: LicD; cl01378 264198016503 long tail fiber, proximal subunit; Provisional; Region: 34; PHA02584 264198016504 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 264198016505 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 264198016506 NnrS protein; Region: NnrS; cl01258 264198016507 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 264198016508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198016509 putative substrate translocation pore; other site 264198016510 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 264198016511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198016512 putative substrate translocation pore; other site 264198016513 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 264198016514 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 264198016515 [4Fe-4S] binding site [ion binding]; other site 264198016516 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 264198016517 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 264198016518 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 264198016519 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 264198016520 molybdopterin cofactor binding site; other site 264198016521 nitrate reductase, beta subunit; Region: narH; TIGR01660 264198016522 4Fe-4S binding domain; Region: Fer4; cl02805 264198016523 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 264198016524 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 264198016525 PPIC-type PPIASE domain; Region: Rotamase; cl08278 264198016526 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 264198016527 active site clefts [active] 264198016528 zinc binding site [ion binding]; other site 264198016529 dimer interface [polypeptide binding]; other site 264198016530 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 264198016531 Walker A motif; other site 264198016532 DGC domain; Region: DGC; cl01742 264198016533 Cytochrome c; Region: Cytochrom_C; cl11414 264198016534 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 264198016535 Cytochrome c; Region: Cytochrom_C; cl11414 264198016536 Cytochrome c; Region: Cytochrom_C; cl11414 264198016537 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 264198016538 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 264198016539 structural tetrad; other site 264198016540 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 264198016541 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264198016542 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264198016543 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264198016544 Helix-turn-helix domains; Region: HTH; cl00088 264198016545 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 264198016546 heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051 264198016547 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264198016548 FeS/SAM binding site; other site 264198016549 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 264198016550 Cytochrome c; Region: Cytochrom_C; cl11414 264198016551 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 264198016552 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 264198016553 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 264198016554 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 264198016555 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198016556 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 264198016557 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198016558 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198016559 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 264198016560 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 264198016561 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 264198016562 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 264198016563 tetramer interface [polypeptide binding]; other site 264198016564 active site 264198016565 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 264198016566 heterodimer interface [polypeptide binding]; other site 264198016567 active site 264198016568 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 264198016569 multimer interface [polypeptide binding]; other site 264198016570 heterodimer interface [polypeptide binding]; other site 264198016571 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 264198016572 active site 264198016573 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 264198016574 Helix-turn-helix domains; Region: HTH; cl00088 264198016575 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198016576 dimerization interface [polypeptide binding]; other site 264198016577 benzoate transport; Region: 2A0115; TIGR00895 264198016578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198016579 putative substrate translocation pore; other site 264198016580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198016581 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 264198016582 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 264198016583 dimer interface [polypeptide binding]; other site 264198016584 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 264198016585 active site 264198016586 Fe binding site [ion binding]; other site 264198016587 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 264198016588 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 264198016589 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 264198016590 NAD(P) binding site [chemical binding]; other site 264198016591 shikimate binding site; other site 264198016592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198016593 D-galactonate transporter; Region: 2A0114; TIGR00893 264198016594 putative substrate translocation pore; other site 264198016595 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198016596 trimer interface [polypeptide binding]; other site 264198016597 eyelet of channel; other site 264198016598 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 264198016599 active site 264198016600 trimer interface [polypeptide binding]; other site 264198016601 dimer interface [polypeptide binding]; other site 264198016602 transcriptional activator TtdR; Provisional; Region: PRK09801 264198016603 Helix-turn-helix domains; Region: HTH; cl00088 264198016604 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198016605 dimerization interface [polypeptide binding]; other site 264198016606 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 264198016607 Helix-turn-helix domains; Region: HTH; cl00088 264198016608 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198016609 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 264198016610 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 264198016611 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 264198016612 dimer interface [polypeptide binding]; other site 264198016613 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 264198016614 active site 264198016615 Fe binding site [ion binding]; other site 264198016616 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 264198016617 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 264198016618 AMP-binding enzyme; Region: AMP-binding; cl15778 264198016619 AMP-binding enzyme; Region: AMP-binding; cl15778 264198016620 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 264198016621 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 264198016622 DNA binding residues [nucleotide binding] 264198016623 Response regulator receiver domain; Region: Response_reg; pfam00072 264198016624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198016625 active site 264198016626 phosphorylation site [posttranslational modification] 264198016627 intermolecular recognition site; other site 264198016628 dimerization interface [polypeptide binding]; other site 264198016629 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198016630 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 264198016631 putative active site [active] 264198016632 heme pocket [chemical binding]; other site 264198016633 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198016634 dimer interface [polypeptide binding]; other site 264198016635 phosphorylation site [posttranslational modification] 264198016636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198016637 ATP binding site [chemical binding]; other site 264198016638 Mg2+ binding site [ion binding]; other site 264198016639 G-X-G motif; other site 264198016640 Response regulator receiver domain; Region: Response_reg; pfam00072 264198016641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198016642 active site 264198016643 phosphorylation site [posttranslational modification] 264198016644 intermolecular recognition site; other site 264198016645 dimerization interface [polypeptide binding]; other site 264198016646 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 264198016647 putative binding surface; other site 264198016648 active site 264198016649 Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 1st repeat which does not contain the putative...; Region: 4RHOD_Repeat_1; cd01532 264198016650 active site residue [active] 264198016651 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 264198016652 active site residue [active] 264198016653 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 264198016654 active site residue [active] 264198016655 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 264198016656 active site residue [active] 264198016657 Cysteine dioxygenase type I; Region: CDO_I; cl15835 264198016658 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198016659 active site 264198016660 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 264198016661 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 264198016662 dimer interface [polypeptide binding]; other site 264198016663 active site 264198016664 non-prolyl cis peptide bond; other site 264198016665 insertion regions; other site 264198016666 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198016667 Helix-turn-helix domain; Region: HTH_18; pfam12833 264198016668 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198016669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198016670 NMT1-like family; Region: NMT1_2; cl15260 264198016671 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 264198016672 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198016673 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198016674 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198016675 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 264198016676 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 264198016677 NAD(P) binding site [chemical binding]; other site 264198016678 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 264198016679 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 264198016680 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 264198016681 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 264198016682 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 264198016683 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 264198016684 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 264198016685 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 264198016686 GAF domain; Region: GAF; cl15785 264198016687 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198016688 Walker A motif; other site 264198016689 ATP binding site [chemical binding]; other site 264198016690 Walker B motif; other site 264198016691 arginine finger; other site 264198016692 Helix-turn-helix domains; Region: HTH; cl00088 264198016693 SCP-2 sterol transfer family; Region: SCP2; cl01225 264198016694 Peptidase family U32; Region: Peptidase_U32; cl03113 264198016695 Peptidase family U32; Region: Peptidase_U32; cl03113 264198016696 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 264198016697 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 264198016698 FMN binding site [chemical binding]; other site 264198016699 substrate binding site [chemical binding]; other site 264198016700 putative catalytic residue [active] 264198016701 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264198016702 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198016703 ligand binding site [chemical binding]; other site 264198016704 flexible hinge region; other site 264198016705 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 264198016706 putative switch regulator; other site 264198016707 non-specific DNA interactions [nucleotide binding]; other site 264198016708 DNA binding site [nucleotide binding] 264198016709 sequence specific DNA binding site [nucleotide binding]; other site 264198016710 putative cAMP binding site [chemical binding]; other site 264198016711 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 264198016712 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 264198016713 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 264198016714 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264198016715 dimerization interface [polypeptide binding]; other site 264198016716 GAF domain; Region: GAF; cl15785 264198016717 Histidine kinase; Region: HisKA_3; pfam07730 264198016718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 264198016719 transcriptional regulator NarL; Provisional; Region: PRK10651 264198016720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198016721 active site 264198016722 phosphorylation site [posttranslational modification] 264198016723 intermolecular recognition site; other site 264198016724 dimerization interface [polypeptide binding]; other site 264198016725 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198016726 DNA binding residues [nucleotide binding] 264198016727 dimerization interface [polypeptide binding]; other site 264198016728 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 264198016729 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198016730 Protein of unknown function (DUF3182); Region: DUF3182; pfam11379 264198016731 Low affinity iron permease; Region: Iron_permease; cl12096 264198016732 BON domain; Region: BON; cl02771 264198016733 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 264198016734 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 264198016735 dimer interface [polypeptide binding]; other site 264198016736 phosphorylation site [posttranslational modification] 264198016737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 264198016738 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 264198016739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198016740 active site 264198016741 phosphorylation site [posttranslational modification] 264198016742 intermolecular recognition site; other site 264198016743 dimerization interface [polypeptide binding]; other site 264198016744 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198016745 Walker A motif; other site 264198016746 ATP binding site [chemical binding]; other site 264198016747 Walker B motif; other site 264198016748 arginine finger; other site 264198016749 Helix-turn-helix domains; Region: HTH; cl00088 264198016750 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 264198016751 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198016752 Walker A motif; other site 264198016753 ATP binding site [chemical binding]; other site 264198016754 Walker B motif; other site 264198016755 arginine finger; other site 264198016756 Helix-turn-helix domains; Region: HTH; cl00088 264198016757 short chain dehydrogenase; Provisional; Region: PRK07109 264198016758 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 264198016759 putative NAD(P) binding site [chemical binding]; other site 264198016760 active site 264198016761 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 264198016762 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 264198016763 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 264198016764 active site 264198016765 DNA binding site [nucleotide binding] 264198016766 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 264198016767 DNA binding site [nucleotide binding] 264198016768 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 264198016769 nucleotide binding site [chemical binding]; other site 264198016770 Response regulator receiver domain; Region: Response_reg; pfam00072 264198016771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198016772 active site 264198016773 phosphorylation site [posttranslational modification] 264198016774 intermolecular recognition site; other site 264198016775 dimerization interface [polypeptide binding]; other site 264198016776 PAS domain; Region: PAS_9; pfam13426 264198016777 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 264198016778 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198016779 dimer interface [polypeptide binding]; other site 264198016780 phosphorylation site [posttranslational modification] 264198016781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198016782 ATP binding site [chemical binding]; other site 264198016783 Mg2+ binding site [ion binding]; other site 264198016784 G-X-G motif; other site 264198016785 Response regulator receiver domain; Region: Response_reg; pfam00072 264198016786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198016787 active site 264198016788 phosphorylation site [posttranslational modification] 264198016789 intermolecular recognition site; other site 264198016790 dimerization interface [polypeptide binding]; other site 264198016791 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 264198016792 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 264198016793 putative DNA binding site [nucleotide binding]; other site 264198016794 putative homodimer interface [polypeptide binding]; other site 264198016795 BON domain; Region: BON; cl02771 264198016796 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 264198016797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198016798 putative substrate translocation pore; other site 264198016799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198016800 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264198016801 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198016802 dimer interface [polypeptide binding]; other site 264198016803 putative CheW interface [polypeptide binding]; other site 264198016804 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 264198016805 flagellin; Validated; Region: PRK06819 264198016806 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 264198016807 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 264198016808 FlaG protein; Region: FlaG; cl00591 264198016809 flagellar capping protein; Reviewed; Region: fliD; PRK08032 264198016810 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 264198016811 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 264198016812 Flagellar protein FliS; Region: FliS; cl00654 264198016813 Flagellar protein FliT; Region: FliT; cl05125 264198016814 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 264198016815 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 264198016816 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 264198016817 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 264198016818 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 264198016819 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 264198016820 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 264198016821 FliG C-terminal domain; Region: FliG_C; pfam01706 264198016822 flagellar assembly protein H; Validated; Region: fliH; PRK05687 264198016823 Flagellar assembly protein FliH; Region: FliH; pfam02108 264198016824 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 264198016825 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 264198016826 Walker A motif/ATP binding site; other site 264198016827 Walker B motif; other site 264198016828 flagellar biosynthesis chaperone; Validated; Region: fliJ; cl09161 264198016829 Flagellar FliJ protein; Region: FliJ; pfam02050 264198016830 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 264198016831 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 264198016832 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 264198016833 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 264198016834 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 264198016835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 264198016836 High potential iron-sulfur protein; Region: HIPIP; pfam01355 264198016837 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198016838 dimer interface [polypeptide binding]; other site 264198016839 putative CheW interface [polypeptide binding]; other site 264198016840 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 264198016841 Uncharacterized conserved protein [Function unknown]; Region: COG1739 264198016842 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 264198016843 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 264198016844 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198016845 catalytic loop [active] 264198016846 iron binding site [ion binding]; other site 264198016847 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198016848 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 264198016849 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 264198016850 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 264198016851 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 264198016852 active site 264198016853 catalytic tetrad [active] 264198016854 Helix-turn-helix domains; Region: HTH; cl00088 264198016855 transcriptional regulator; Provisional; Region: PRK10632 264198016856 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 264198016857 putative effector binding pocket; other site 264198016858 dimerization interface [polypeptide binding]; other site 264198016859 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 264198016860 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 264198016861 Peptidase M30; Region: Peptidase_M30; pfam10460 264198016862 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198016863 Helix-turn-helix domains; Region: HTH; cl00088 264198016864 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198016865 dimerization interface [polypeptide binding]; other site 264198016866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198016867 D-galactonate transporter; Region: 2A0114; TIGR00893 264198016868 putative substrate translocation pore; other site 264198016869 Creatinine amidohydrolase; Region: Creatininase; cl00618 264198016870 OsmC-like protein; Region: OsmC; cl00767 264198016871 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 264198016872 homotrimer interaction site [polypeptide binding]; other site 264198016873 putative active site [active] 264198016874 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198016875 classical (c) SDRs; Region: SDR_c; cd05233 264198016876 NAD(P) binding site [chemical binding]; other site 264198016877 active site 264198016878 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198016879 Helix-turn-helix domains; Region: HTH; cl00088 264198016880 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198016881 dimerization interface [polypeptide binding]; other site 264198016882 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 264198016883 FMN binding site [chemical binding]; other site 264198016884 substrate binding site [chemical binding]; other site 264198016885 putative catalytic residue [active] 264198016886 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 264198016887 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 264198016888 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 264198016889 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264198016890 non-specific DNA binding site [nucleotide binding]; other site 264198016891 salt bridge; other site 264198016892 sequence-specific DNA binding site [nucleotide binding]; other site 264198016893 Cupin domain; Region: Cupin_2; cl09118 264198016894 aminopeptidase N; Provisional; Region: pepN; PRK14015 264198016895 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 264198016896 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 264198016897 DNA-binding site [nucleotide binding]; DNA binding site 264198016898 RNA-binding motif; other site 264198016899 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 264198016900 Cache domain; Region: Cache_1; pfam02743 264198016901 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264198016902 dimerization interface [polypeptide binding]; other site 264198016903 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264198016904 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198016905 dimer interface [polypeptide binding]; other site 264198016906 putative CheW interface [polypeptide binding]; other site 264198016907 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198016908 trimer interface [polypeptide binding]; other site 264198016909 eyelet of channel; other site 264198016910 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 264198016911 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264198016912 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198016913 DNA-binding site [nucleotide binding]; DNA binding site 264198016914 FCD domain; Region: FCD; cl11656 264198016915 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 264198016916 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 264198016917 homodimer interface [polypeptide binding]; other site 264198016918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198016919 catalytic residue [active] 264198016920 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198016921 D-galactonate transporter; Region: 2A0114; TIGR00893 264198016922 putative substrate translocation pore; other site 264198016923 amidase; Provisional; Region: PRK08137 264198016924 Amidase; Region: Amidase; cl11426 264198016925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198016926 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198016927 putative substrate translocation pore; other site 264198016928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198016929 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 264198016930 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 264198016931 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198016932 NMT1-like family; Region: NMT1_2; cl15260 264198016933 tricarballylate utilization protein B; Provisional; Region: PRK15033 264198016934 tricarballylate dehydrogenase; Validated; Region: PRK08274 264198016935 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 264198016936 Helix-turn-helix domains; Region: HTH; cl00088 264198016937 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 264198016938 putative dimerization interface [polypeptide binding]; other site 264198016939 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 264198016940 putative dimer interface [polypeptide binding]; other site 264198016941 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 264198016942 putative dimer interface [polypeptide binding]; other site 264198016943 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 264198016944 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 264198016945 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 264198016946 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198016947 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198016948 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264198016949 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198016950 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 264198016951 classical (c) SDRs; Region: SDR_c; cd05233 264198016952 NAD(P) binding site [chemical binding]; other site 264198016953 active site 264198016954 Uncharacterized conserved protein [Function unknown]; Region: COG5361 264198016955 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 264198016956 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 264198016957 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 264198016958 Uncharacterized conserved protein [Function unknown]; Region: COG5361 264198016959 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 264198016960 ApbE family; Region: ApbE; cl00643 264198016961 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 264198016962 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 264198016963 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 264198016964 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like2; cd06201 264198016965 FAD binding pocket [chemical binding]; other site 264198016966 FAD binding motif [chemical binding]; other site 264198016967 catalytic residues [active] 264198016968 NAD binding pocket [chemical binding]; other site 264198016969 phosphate binding motif [ion binding]; other site 264198016970 beta-alpha-beta structure motif; other site 264198016971 FlgD Ig-like domain; Region: FlgD_ig; cl15790 264198016972 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 264198016973 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 264198016974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198016975 active site 264198016976 phosphorylation site [posttranslational modification] 264198016977 intermolecular recognition site; other site 264198016978 dimerization interface [polypeptide binding]; other site 264198016979 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198016980 DNA binding site [nucleotide binding] 264198016981 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264198016982 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198016983 dimer interface [polypeptide binding]; other site 264198016984 phosphorylation site [posttranslational modification] 264198016985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198016986 ATP binding site [chemical binding]; other site 264198016987 Mg2+ binding site [ion binding]; other site 264198016988 G-X-G motif; other site 264198016989 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 264198016990 Cation efflux family; Region: Cation_efflux; cl00316 264198016991 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264198016992 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198016993 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198016994 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264198016995 FtsX-like permease family; Region: FtsX; cl15850 264198016996 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 264198016997 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 264198016998 Walker A/P-loop; other site 264198016999 ATP binding site [chemical binding]; other site 264198017000 Q-loop/lid; other site 264198017001 ABC transporter signature motif; other site 264198017002 Walker B; other site 264198017003 D-loop; other site 264198017004 H-loop/switch region; other site 264198017005 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264198017006 Ligand Binding Site [chemical binding]; other site 264198017007 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 264198017008 benzoate transport; Region: 2A0115; TIGR00895 264198017009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198017010 putative substrate translocation pore; other site 264198017011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198017012 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 264198017013 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 264198017014 GDP-binding site [chemical binding]; other site 264198017015 ACT binding site; other site 264198017016 IMP binding site; other site 264198017017 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 264198017018 homotrimer interaction site [polypeptide binding]; other site 264198017019 putative active site [active] 264198017020 Cupin domain; Region: Cupin_2; cl09118 264198017021 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 264198017022 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198017023 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 264198017024 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198017025 substrate binding pocket [chemical binding]; other site 264198017026 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 264198017027 DNA-binding site [nucleotide binding]; DNA binding site 264198017028 RNA-binding motif; other site 264198017029 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 264198017030 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 264198017031 rRNA binding site [nucleotide binding]; other site 264198017032 predicted 30S ribosome binding site; other site 264198017033 CheB methylesterase; Region: CheB_methylest; pfam01339 264198017034 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 264198017035 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 264198017036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 264198017037 PAS domain; Region: PAS_10; pfam13596 264198017038 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 264198017039 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 264198017040 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 264198017041 ring oligomerisation interface [polypeptide binding]; other site 264198017042 ATP/Mg binding site [chemical binding]; other site 264198017043 stacking interactions; other site 264198017044 hinge regions; other site 264198017045 FtsH Extracellular; Region: FtsH_ext; pfam06480 264198017046 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 264198017047 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198017048 Walker A motif; other site 264198017049 ATP binding site [chemical binding]; other site 264198017050 Walker B motif; other site 264198017051 arginine finger; other site 264198017052 Peptidase family M41; Region: Peptidase_M41; pfam01434 264198017053 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 264198017054 Erythromycin esterase; Region: Erythro_esteras; pfam05139 264198017055 Helix-turn-helix domains; Region: HTH; cl00088 264198017056 LysR family transcriptional regulator; Provisional; Region: PRK14997 264198017057 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198017058 putative effector binding pocket; other site 264198017059 dimerization interface [polypeptide binding]; other site 264198017060 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 264198017061 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 264198017062 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 264198017063 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 264198017064 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 264198017065 NAD binding site [chemical binding]; other site 264198017066 catalytic Zn binding site [ion binding]; other site 264198017067 substrate binding site [chemical binding]; other site 264198017068 structural Zn binding site [ion binding]; other site 264198017069 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 264198017070 PLD-like domain; Region: PLDc_2; pfam13091 264198017071 putative active site [active] 264198017072 catalytic site [active] 264198017073 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 264198017074 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 264198017075 putative active site [active] 264198017076 catalytic site [active] 264198017077 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 264198017078 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198017079 CoA-ligase; Region: Ligase_CoA; cl02894 264198017080 ATP-grasp domain; Region: ATP-grasp_4; cl03087 264198017081 NMT1-like family; Region: NMT1_2; cl15260 264198017082 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198017083 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198017084 NAD(P) binding site [chemical binding]; other site 264198017085 active site 264198017086 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198017087 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198017088 active site 264198017089 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 264198017090 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198017091 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198017092 Haemolysin-III related; Region: HlyIII; cl03831 264198017093 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 264198017094 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 264198017095 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 264198017096 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 264198017097 FAD binding pocket [chemical binding]; other site 264198017098 FAD binding motif [chemical binding]; other site 264198017099 catalytic residues [active] 264198017100 NAD binding pocket [chemical binding]; other site 264198017101 phosphate binding motif [ion binding]; other site 264198017102 beta-alpha-beta structure motif; other site 264198017103 ApbE family; Region: ApbE; cl00643 264198017104 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 264198017105 FlgD Ig-like domain; Region: FlgD_ig; cl15790 264198017106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 264198017107 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 264198017108 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198017109 trimer interface [polypeptide binding]; other site 264198017110 eyelet of channel; other site 264198017111 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 264198017112 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 264198017113 metal binding site [ion binding]; metal-binding site 264198017114 putative dimer interface [polypeptide binding]; other site 264198017115 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 264198017116 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198017117 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198017118 Helix-turn-helix domains; Region: HTH; cl00088 264198017119 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 264198017120 putative dimerization interface [polypeptide binding]; other site 264198017121 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 264198017122 YCII-related domain; Region: YCII; cl00999 264198017123 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 264198017124 DctM-like transporters; Region: DctM; pfam06808 264198017125 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 264198017126 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 264198017127 trimer interface [polypeptide binding]; other site 264198017128 putative Zn binding site [ion binding]; other site 264198017129 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 264198017130 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 264198017131 Chromate transporter; Region: Chromate_transp; pfam02417 264198017132 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 264198017133 Chromate transporter; Region: Chromate_transp; pfam02417 264198017134 Cache domain; Region: Cache_2; cl07034 264198017135 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264198017136 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198017137 dimer interface [polypeptide binding]; other site 264198017138 putative CheW interface [polypeptide binding]; other site 264198017139 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 264198017140 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 264198017141 Transglycosylase; Region: Transgly; cl07896 264198017142 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 264198017143 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 264198017144 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 264198017145 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 264198017146 active site 264198017147 catalytic tetrad [active] 264198017148 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 264198017149 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198017150 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 264198017151 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 264198017152 DXD motif; other site 264198017153 PilZ domain; Region: PilZ; cl01260 264198017154 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264198017155 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 264198017156 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 264198017157 putative active site [active] 264198017158 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 264198017159 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 264198017160 Ligand Binding Site [chemical binding]; other site 264198017161 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198017162 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198017163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198017164 NMT1-like family; Region: NMT1_2; cl15260 264198017165 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198017166 enoyl-CoA hydratase; Provisional; Region: PRK06688 264198017167 substrate binding site [chemical binding]; other site 264198017168 oxyanion hole (OAH) forming residues; other site 264198017169 trimer interface [polypeptide binding]; other site 264198017170 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198017171 Helix-turn-helix domains; Region: HTH; cl00088 264198017172 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 264198017173 putative dimerization interface [polypeptide binding]; other site 264198017174 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 264198017175 dimer interface [polypeptide binding]; other site 264198017176 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198017177 SlyX; Region: SlyX; cl01090 264198017178 Protein of unknown function (DUF1439); Region: DUF1439; cl06345 264198017179 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 264198017180 Helix-turn-helix domains; Region: HTH; cl00088 264198017181 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264198017182 dimerization interface [polypeptide binding]; other site 264198017183 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198017184 NMT1-like family; Region: NMT1_2; cl15260 264198017185 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 264198017186 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 264198017187 active site 264198017188 putative substrate binding pocket [chemical binding]; other site 264198017189 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198017190 NAD-dependent deacetylase; Provisional; Region: PRK05333 264198017191 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 264198017192 NAD+ binding site [chemical binding]; other site 264198017193 substrate binding site [chemical binding]; other site 264198017194 Zn binding site [ion binding]; other site 264198017195 Oxidoreductase-like protein, N-terminal; Region: Oxidored-like; pfam09791 264198017196 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 264198017197 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 264198017198 active site 264198017199 nucleophile elbow; other site 264198017200 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 264198017201 Surface antigen; Region: Bac_surface_Ag; cl03097 264198017202 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 264198017203 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 264198017204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198017205 Walker A motif; other site 264198017206 ATP binding site [chemical binding]; other site 264198017207 Walker B motif; other site 264198017208 arginine finger; other site 264198017209 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198017210 Walker A motif; other site 264198017211 ATP binding site [chemical binding]; other site 264198017212 Walker B motif; other site 264198017213 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 264198017214 Protein of unknown function (DUF796); Region: DUF796; cl01226 264198017215 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 264198017216 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264198017217 ligand binding site [chemical binding]; other site 264198017218 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 264198017219 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 264198017220 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 264198017221 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 264198017222 Protein of unknown function (DUF877); Region: DUF877; pfam05943 264198017223 Protein of unknown function (DUF770); Region: DUF770; cl01402 264198017224 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 264198017225 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 264198017226 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 264198017227 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 264198017228 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 264198017229 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198017230 ADP-dependent glucokinase; Provisional; Region: PRK14039 264198017231 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 264198017232 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 264198017233 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 264198017234 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 264198017235 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 264198017236 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 264198017237 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 264198017238 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 264198017239 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 264198017240 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198017241 Helix-turn-helix domains; Region: HTH; cl00088 264198017242 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198017243 NMT1-like family; Region: NMT1_2; cl15260 264198017244 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 264198017245 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 264198017246 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 264198017247 FMN-binding pocket [chemical binding]; other site 264198017248 flavin binding motif; other site 264198017249 phosphate binding motif [ion binding]; other site 264198017250 beta-alpha-beta structure motif; other site 264198017251 NAD binding pocket [chemical binding]; other site 264198017252 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198017253 catalytic loop [active] 264198017254 iron binding site [ion binding]; other site 264198017255 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198017256 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 264198017257 NAD(P) binding site [chemical binding]; other site 264198017258 catalytic residues [active] 264198017259 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198017260 Helix-turn-helix domains; Region: HTH; cl00088 264198017261 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198017262 dimerization interface [polypeptide binding]; other site 264198017263 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 264198017264 DUF35 OB-fold domain; Region: DUF35; pfam01796 264198017265 lipid-transfer protein; Provisional; Region: PRK07855 264198017266 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 264198017267 active site 264198017268 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 264198017269 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264198017270 substrate binding site [chemical binding]; other site 264198017271 oxyanion hole (OAH) forming residues; other site 264198017272 trimer interface [polypeptide binding]; other site 264198017273 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 264198017274 AMP-binding enzyme; Region: AMP-binding; cl15778 264198017275 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198017276 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198017277 active site 264198017278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198017279 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 264198017280 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 264198017281 putative active site [active] 264198017282 putative substrate binding site [chemical binding]; other site 264198017283 ATP binding site [chemical binding]; other site 264198017284 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198017285 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198017286 active site 264198017287 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198017288 classical (c) SDRs; Region: SDR_c; cd05233 264198017289 NAD(P) binding site [chemical binding]; other site 264198017290 active site 264198017291 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 264198017292 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 264198017293 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 264198017294 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 264198017295 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 264198017296 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198017297 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 264198017298 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 264198017299 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 264198017300 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 264198017301 NAD(P) binding site [chemical binding]; other site 264198017302 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 264198017303 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 264198017304 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 264198017305 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 264198017306 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198017307 DNA-binding site [nucleotide binding]; DNA binding site 264198017308 UTRA domain; Region: UTRA; cl01230 264198017309 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 264198017310 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13029 264198017311 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 264198017312 dimer interface [polypeptide binding]; other site 264198017313 PYR/PP interface [polypeptide binding]; other site 264198017314 TPP binding site [chemical binding]; other site 264198017315 substrate binding site [chemical binding]; other site 264198017316 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 264198017317 TPP-binding site [chemical binding]; other site 264198017318 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 264198017319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198017320 NMT1-like family; Region: NMT1_2; cl15260 264198017321 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198017322 NMT1-like family; Region: NMT1_2; cl15260 264198017323 metabolite-proton symporter; Region: 2A0106; TIGR00883 264198017324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198017325 putative substrate translocation pore; other site 264198017326 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198017327 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198017328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198017329 NMT1-like family; Region: NMT1_2; cl15260 264198017330 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198017331 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 264198017332 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 264198017333 active site 264198017334 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 264198017335 AMP-binding enzyme; Region: AMP-binding; cl15778 264198017336 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198017337 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198017338 Helix-turn-helix domains; Region: HTH; cl00088 264198017339 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198017340 dimerization interface [polypeptide binding]; other site 264198017341 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 264198017342 Helix-turn-helix domains; Region: HTH; cl00088 264198017343 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198017344 Flagellar regulator YcgR; Region: YcgR; pfam07317 264198017345 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 264198017346 PilZ domain; Region: PilZ; cl01260 264198017347 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 264198017348 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 264198017349 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 264198017350 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 264198017351 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 264198017352 DNA binding site [nucleotide binding] 264198017353 active site 264198017354 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 264198017355 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 264198017356 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198017357 AlkA N-terminal domain; Region: AlkA_N; cl05528 264198017358 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 264198017359 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 264198017360 minor groove reading motif; other site 264198017361 helix-hairpin-helix signature motif; other site 264198017362 substrate binding pocket [chemical binding]; other site 264198017363 active site 264198017364 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 264198017365 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 264198017366 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 264198017367 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 264198017368 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 264198017369 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198017370 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198017371 active site 264198017372 OPT oligopeptide transporter protein; Region: OPT; cl14607 264198017373 OPT oligopeptide transporter protein; Region: OPT; cl14607 264198017374 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 264198017375 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198017376 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198017377 Helix-turn-helix domains; Region: HTH; cl00088 264198017378 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264198017379 hypothetical protein; Provisional; Region: PRK11770 264198017380 Domain of unknown function (DUF307); Region: DUF307; pfam03733 264198017381 Domain of unknown function (DUF307); Region: DUF307; pfam03733 264198017382 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264198017383 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 264198017384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198017385 ATP binding site [chemical binding]; other site 264198017386 Mg2+ binding site [ion binding]; other site 264198017387 G-X-G motif; other site 264198017388 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 264198017389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198017390 active site 264198017391 phosphorylation site [posttranslational modification] 264198017392 intermolecular recognition site; other site 264198017393 dimerization interface [polypeptide binding]; other site 264198017394 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264198017395 DNA binding site [nucleotide binding] 264198017396 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 264198017397 glucokinase, proteobacterial type; Region: glk; TIGR00749 264198017398 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 264198017399 putative active site [active] 264198017400 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 264198017401 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 264198017402 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 264198017403 Dehydratase family; Region: ILVD_EDD; cl00340 264198017404 6-phosphogluconate dehydratase; Region: edd; TIGR01196 264198017405 mechanosensitive channel MscS; Provisional; Region: PRK10334 264198017406 Conserved TM helix; Region: TM_helix; pfam05552 264198017407 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264198017408 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 264198017409 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198017410 H+ Antiporter protein; Region: 2A0121; TIGR00900 264198017411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198017412 putative substrate translocation pore; other site 264198017413 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 264198017414 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 264198017415 G1 box; other site 264198017416 putative GEF interaction site [polypeptide binding]; other site 264198017417 GTP/Mg2+ binding site [chemical binding]; other site 264198017418 Switch I region; other site 264198017419 G2 box; other site 264198017420 G3 box; other site 264198017421 Switch II region; other site 264198017422 G4 box; other site 264198017423 G5 box; other site 264198017424 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 264198017425 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 264198017426 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 264198017427 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198017428 Walker A motif; other site 264198017429 ATP binding site [chemical binding]; other site 264198017430 Walker B motif; other site 264198017431 arginine finger; other site 264198017432 Helix-turn-helix domains; Region: HTH; cl00088 264198017433 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 264198017434 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 264198017435 DNA-binding site [nucleotide binding]; DNA binding site 264198017436 RNA-binding motif; other site 264198017437 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 264198017438 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 264198017439 DNA-binding site [nucleotide binding]; DNA binding site 264198017440 RNA-binding motif; other site 264198017441 ParA-like protein; Provisional; Region: PHA02518 264198017442 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 264198017443 P-loop; other site 264198017444 Magnesium ion binding site [ion binding]; other site 264198017445 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 264198017446 ParB-like nuclease domain; Region: ParBc; cl02129 264198017447 Phage integrase protein; Region: DUF3701; pfam12482 264198017448 PAS fold; Region: PAS_4; pfam08448 264198017449 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198017450 putative active site [active] 264198017451 heme pocket [chemical binding]; other site 264198017452 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198017453 dimer interface [polypeptide binding]; other site 264198017454 phosphorylation site [posttranslational modification] 264198017455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198017456 ATP binding site [chemical binding]; other site 264198017457 Mg2+ binding site [ion binding]; other site 264198017458 G-X-G motif; other site 264198017459 Response regulator receiver domain; Region: Response_reg; pfam00072 264198017460 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198017461 active site 264198017462 phosphorylation site [posttranslational modification] 264198017463 intermolecular recognition site; other site 264198017464 dimerization interface [polypeptide binding]; other site 264198017465 MatE; Region: MatE; cl10513 264198017466 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 264198017467 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 264198017468 Probable Catalytic site; other site 264198017469 metal-binding site 264198017470 Benzoate membrane transport protein; Region: BenE; pfam03594 264198017471 benzoate transporter; Region: benE; TIGR00843 264198017472 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198017473 DNA binding residues [nucleotide binding] 264198017474 dimerization interface [polypeptide binding]; other site 264198017475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 264198017476 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 264198017477 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 264198017478 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264198017479 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198017480 ligand binding site [chemical binding]; other site 264198017481 flexible hinge region; other site 264198017482 Helix-turn-helix domains; Region: HTH; cl00088 264198017483 non-specific DNA interactions [nucleotide binding]; other site 264198017484 DNA binding site [nucleotide binding] 264198017485 sequence specific DNA binding site [nucleotide binding]; other site 264198017486 putative cAMP binding site [chemical binding]; other site 264198017487 tyrosine kinase; Provisional; Region: PRK11519 264198017488 Chain length determinant protein; Region: Wzz; cl15801 264198017489 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198017490 Phosphopantetheine attachment site; Region: PP-binding; cl09936 264198017491 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198017492 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198017493 Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670 264198017494 dimer interface [polypeptide binding]; other site 264198017495 motif 1; other site 264198017496 active site 264198017497 motif 2; other site 264198017498 motif 3; other site 264198017499 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 264198017500 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 264198017501 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 264198017502 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 264198017503 Bacterial sugar transferase; Region: Bac_transf; cl00939 264198017504 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 264198017505 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 264198017506 putative trimer interface [polypeptide binding]; other site 264198017507 putative CoA binding site [chemical binding]; other site 264198017508 tyrosine kinase; Provisional; Region: PRK11519 264198017509 Chain length determinant protein; Region: Wzz; cl15801 264198017510 Chain length determinant protein; Region: Wzz; cl15801 264198017511 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 264198017512 Nucleotide binding site [chemical binding]; other site 264198017513 DTAP/Switch II; other site 264198017514 Switch I; other site 264198017515 Low molecular weight phosphatase family; Region: LMWPc; cd00115 264198017516 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 264198017517 active site 264198017518 polysaccharide export protein Wza; Provisional; Region: PRK15078 264198017519 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 264198017520 SLBB domain; Region: SLBB; pfam10531 264198017521 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 264198017522 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 264198017523 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264198017524 putative ADP-binding pocket [chemical binding]; other site 264198017525 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 264198017526 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 264198017527 active site 264198017528 dimer interface [polypeptide binding]; other site 264198017529 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 264198017530 Ligand Binding Site [chemical binding]; other site 264198017531 Molecular Tunnel; other site 264198017532 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 264198017533 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 264198017534 NAD binding site [chemical binding]; other site 264198017535 substrate binding site [chemical binding]; other site 264198017536 homodimer interface [polypeptide binding]; other site 264198017537 active site 264198017538 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 264198017539 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 264198017540 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198017541 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 264198017542 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 264198017543 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 264198017544 NAD(P) binding site [chemical binding]; other site 264198017545 homodimer interface [polypeptide binding]; other site 264198017546 substrate binding site [chemical binding]; other site 264198017547 active site 264198017548 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 264198017549 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 264198017550 inhibitor-cofactor binding pocket; inhibition site 264198017551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198017552 catalytic residue [active] 264198017553 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 264198017554 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 264198017555 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 264198017556 active site 264198017557 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198017558 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198017559 DNA binding residues [nucleotide binding] 264198017560 dimerization interface [polypeptide binding]; other site 264198017561 putative cyanate transporter; Provisional; Region: cynX; PRK09705 264198017562 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 264198017563 nucleoside/Zn binding site; other site 264198017564 dimer interface [polypeptide binding]; other site 264198017565 catalytic motif [active] 264198017566 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198017567 Helix-turn-helix domains; Region: HTH; cl00088 264198017568 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198017569 dimerization interface [polypeptide binding]; other site 264198017570 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 264198017571 active site 264198017572 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 264198017573 substrate binding site [chemical binding]; other site 264198017574 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 264198017575 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 264198017576 substrate binding site [chemical binding]; other site 264198017577 ligand binding site [chemical binding]; other site 264198017578 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198017579 NMT1-like family; Region: NMT1_2; cl15260 264198017580 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 264198017581 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198017582 DNA-binding site [nucleotide binding]; DNA binding site 264198017583 UTRA domain; Region: UTRA; cl01230 264198017584 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39G; cd02423 264198017585 putative active site [active] 264198017586 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 264198017587 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 264198017588 putative ligand binding site [chemical binding]; other site 264198017589 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 264198017590 Helix-turn-helix domains; Region: HTH; cl00088 264198017591 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 264198017592 putative dimerization interface [polypeptide binding]; other site 264198017593 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 264198017594 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198017595 NMT1-like family; Region: NMT1_2; cl15260 264198017596 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 264198017597 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264198017598 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 264198017599 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 264198017600 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 264198017601 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 264198017602 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 264198017603 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 264198017604 Response regulator receiver domain; Region: Response_reg; pfam00072 264198017605 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 264198017606 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 264198017607 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 264198017608 ATP binding site [chemical binding]; other site 264198017609 Walker A motif; other site 264198017610 hexamer interface [polypeptide binding]; other site 264198017611 Walker B motif; other site 264198017612 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 264198017613 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 264198017614 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264198017615 TPR motif; other site 264198017616 TPR repeat; Region: TPR_11; pfam13414 264198017617 binding surface 264198017618 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 264198017619 Predicted membrane protein [Function unknown]; Region: COG4655 264198017620 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 264198017621 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 264198017622 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198017623 Walker A motif; other site 264198017624 ATP binding site [chemical binding]; other site 264198017625 Walker B motif; other site 264198017626 arginine finger; other site 264198017627 Helix-turn-helix domains; Region: HTH; cl00088 264198017628 Cytochrome c; Region: Cytochrom_C; cl11414 264198017629 Cytochrome c; Region: Cytochrom_C; cl11414 264198017630 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 264198017631 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 264198017632 Trp docking motif [polypeptide binding]; other site 264198017633 active site 264198017634 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 264198017635 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 264198017636 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 264198017637 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 264198017638 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 264198017639 structural tetrad; other site 264198017640 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 264198017641 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 264198017642 N-terminal plug; other site 264198017643 ligand-binding site [chemical binding]; other site 264198017644 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 264198017645 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198017646 Predicted acetyltransferase [General function prediction only]; Region: COG3153 264198017647 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264198017648 Coenzyme A binding pocket [chemical binding]; other site 264198017649 AMP nucleosidase; Provisional; Region: PRK08292 264198017650 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 264198017651 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 264198017652 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 264198017653 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 264198017654 ferrous iron transporter FeoB; Region: feoB; TIGR00437 264198017655 G1 box; other site 264198017656 GTP/Mg2+ binding site [chemical binding]; other site 264198017657 Switch I region; other site 264198017658 G2 box; other site 264198017659 G3 box; other site 264198017660 Switch II region; other site 264198017661 G4 box; other site 264198017662 G5 box; other site 264198017663 Nucleoside recognition; Region: Gate; cl00486 264198017664 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 264198017665 Nucleoside recognition; Region: Gate; cl00486 264198017666 FeoA domain; Region: FeoA; cl00838 264198017667 Helix-turn-helix domains; Region: HTH; cl00088 264198017668 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 264198017669 active site 264198017670 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 264198017671 dimer interface [polypeptide binding]; other site 264198017672 non-prolyl cis peptide bond; other site 264198017673 insertion regions; other site 264198017674 Flavin Reductases; Region: FlaRed; cl00801 264198017675 Putative cyclase; Region: Cyclase; cl00814 264198017676 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198017677 trimer interface [polypeptide binding]; other site 264198017678 eyelet of channel; other site 264198017679 Helix-turn-helix domains; Region: HTH; cl00088 264198017680 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 264198017681 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_2; cd08448 264198017682 putative dimerization interface [polypeptide binding]; other site 264198017683 putative substrate binding pocket [chemical binding]; other site 264198017684 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198017685 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198017686 active site 264198017687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198017688 NMT1-like family; Region: NMT1_2; cl15260 264198017689 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 264198017690 CoA-transferase family III; Region: CoA_transf_3; pfam02515 264198017691 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198017692 NMT1-like family; Region: NMT1_2; cl15260 264198017693 methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463 264198017694 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 264198017695 Cysteine dioxygenase type I; Region: CDO_I; cl15835 264198017696 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198017697 Helix-turn-helix domains; Region: HTH; cl00088 264198017698 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 264198017699 putative dimerization interface [polypeptide binding]; other site 264198017700 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198017701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198017702 NAD(P) binding site [chemical binding]; other site 264198017703 active site 264198017704 L-lactate permease; Region: Lactate_perm; cl00701 264198017705 glycolate transporter; Provisional; Region: PRK09695 264198017706 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 264198017707 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 264198017708 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 264198017709 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 264198017710 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 264198017711 Cysteine-rich domain; Region: CCG; pfam02754 264198017712 Cysteine-rich domain; Region: CCG; pfam02754 264198017713 Transcriptional regulators [Transcription]; Region: FadR; COG2186 264198017714 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198017715 DNA-binding site [nucleotide binding]; DNA binding site 264198017716 FCD domain; Region: FCD; cl11656 264198017717 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 264198017718 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198017719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198017720 active site 264198017721 phosphorylation site [posttranslational modification] 264198017722 intermolecular recognition site; other site 264198017723 dimerization interface [polypeptide binding]; other site 264198017724 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198017725 DNA binding residues [nucleotide binding] 264198017726 dimerization interface [polypeptide binding]; other site 264198017727 MASE1; Region: MASE1; pfam05231 264198017728 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 264198017729 Histidine kinase; Region: HisKA_3; pfam07730 264198017730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198017731 ATP binding site [chemical binding]; other site 264198017732 Mg2+ binding site [ion binding]; other site 264198017733 G-X-G motif; other site 264198017734 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 264198017735 trimer interface [polypeptide binding]; other site 264198017736 putative Zn binding site [ion binding]; other site 264198017737 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 264198017738 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198017739 Helix-turn-helix domains; Region: HTH; cl00088 264198017740 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198017741 dimerization interface [polypeptide binding]; other site 264198017742 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 264198017743 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198017744 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198017745 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 264198017746 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 264198017747 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198017748 NAD(P) binding site [chemical binding]; other site 264198017749 active site 264198017750 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198017751 classical (c) SDRs; Region: SDR_c; cd05233 264198017752 NAD(P) binding site [chemical binding]; other site 264198017753 active site 264198017754 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 264198017755 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 264198017756 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 264198017757 Uncharacterized conserved protein [Function unknown]; Region: COG5361 264198017758 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 264198017759 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 264198017760 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264198017761 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 264198017762 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 264198017763 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198017764 metal binding site [ion binding]; metal-binding site 264198017765 active site 264198017766 I-site; other site 264198017767 benzoate transport; Region: 2A0115; TIGR00895 264198017768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198017769 putative substrate translocation pore; other site 264198017770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198017771 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 264198017772 proline aminopeptidase P II; Provisional; Region: PRK10879 264198017773 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 264198017774 active site 264198017775 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 264198017776 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 264198017777 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 264198017778 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 264198017779 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 264198017780 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198017781 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198017782 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198017783 DNA binding residues [nucleotide binding] 264198017784 dimerization interface [polypeptide binding]; other site 264198017785 Avidin family; Region: Avidin; pfam01382 264198017786 Helix-turn-helix domains; Region: HTH; cl00088 264198017787 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198017788 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264198017789 benzoate transport; Region: 2A0115; TIGR00895 264198017790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198017791 putative substrate translocation pore; other site 264198017792 hypothetical protein; Provisional; Region: PRK06847 264198017793 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198017794 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198017795 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 264198017796 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 264198017797 AMP-binding enzyme; Region: AMP-binding; cl15778 264198017798 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198017799 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 264198017800 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198017801 Zn binding site [ion binding]; other site 264198017802 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198017803 Helix-turn-helix domains; Region: HTH; cl00088 264198017804 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 264198017805 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 264198017806 putative active site [active] 264198017807 putative metal binding site [ion binding]; other site 264198017808 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 264198017809 PhoD-like phosphatase; Region: PhoD; pfam09423 264198017810 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 264198017811 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 264198017812 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 264198017813 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 264198017814 putative deacylase active site [active] 264198017815 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198017816 Helix-turn-helix domains; Region: HTH; cl00088 264198017817 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198017818 putative effector binding pocket; other site 264198017819 dimerization interface [polypeptide binding]; other site 264198017820 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 264198017821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198017822 putative substrate translocation pore; other site 264198017823 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 264198017824 Helix-turn-helix domains; Region: HTH; cl00088 264198017825 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198017826 dimerization interface [polypeptide binding]; other site 264198017827 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198017828 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 264198017829 NAD binding site [chemical binding]; other site 264198017830 catalytic residues [active] 264198017831 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 264198017832 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 264198017833 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 264198017834 homotrimer interaction site [polypeptide binding]; other site 264198017835 putative active site [active] 264198017836 Cupin domain; Region: Cupin_2; cl09118 264198017837 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198017838 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198017839 Helix-turn-helix domains; Region: HTH; cl00088 264198017840 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 264198017841 putative dimerization interface [polypeptide binding]; other site 264198017842 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 264198017843 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198017844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198017845 NMT1-like family; Region: NMT1_2; cl15260 264198017846 hypothetical protein; Provisional; Region: PRK08204 264198017847 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198017848 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198017849 active site 264198017850 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 264198017851 homotrimer interaction site [polypeptide binding]; other site 264198017852 putative active site [active] 264198017853 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198017854 trimer interface [polypeptide binding]; other site 264198017855 eyelet of channel; other site 264198017856 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 264198017857 Helix-turn-helix domains; Region: HTH; cl00088 264198017858 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264198017859 dimerization interface [polypeptide binding]; other site 264198017860 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198017861 NMT1-like family; Region: NMT1_2; cl15260 264198017862 Uncharacterized conserved protein [Function unknown]; Region: COG5476 264198017863 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 264198017864 MlrC C-terminus; Region: MlrC_C; pfam07171 264198017865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198017866 NMT1-like family; Region: NMT1_2; cl15260 264198017867 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 264198017868 fumarate hydratase; Reviewed; Region: fumC; PRK00485 264198017869 Class II fumarases; Region: Fumarase_classII; cd01362 264198017870 active site 264198017871 tetramer interface [polypeptide binding]; other site 264198017872 Helix-turn-helix domains; Region: HTH; cl00088 264198017873 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 264198017874 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264198017875 dimerization interface [polypeptide binding]; other site 264198017876 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 264198017877 dimerization interface [polypeptide binding]; other site 264198017878 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264198017879 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 264198017880 PAS fold; Region: PAS_4; pfam08448 264198017881 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198017882 metal binding site [ion binding]; metal-binding site 264198017883 active site 264198017884 I-site; other site 264198017885 CHASE domain; Region: CHASE; cl01369 264198017886 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 264198017887 PAS domain; Region: PAS_9; pfam13426 264198017888 PAS domain S-box; Region: sensory_box; TIGR00229 264198017889 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198017890 putative active site [active] 264198017891 heme pocket [chemical binding]; other site 264198017892 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198017893 metal binding site [ion binding]; metal-binding site 264198017894 active site 264198017895 I-site; other site 264198017896 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264198017897 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 264198017898 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198017899 Walker A/P-loop; other site 264198017900 ATP binding site [chemical binding]; other site 264198017901 Q-loop/lid; other site 264198017902 ABC transporter signature motif; other site 264198017903 Walker B; other site 264198017904 D-loop; other site 264198017905 H-loop/switch region; other site 264198017906 TOBE domain; Region: TOBE_2; cl01440 264198017907 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 264198017908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198017909 dimer interface [polypeptide binding]; other site 264198017910 conserved gate region; other site 264198017911 ABC-ATPase subunit interface; other site 264198017912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198017913 dimer interface [polypeptide binding]; other site 264198017914 conserved gate region; other site 264198017915 putative PBP binding loops; other site 264198017916 ABC-ATPase subunit interface; other site 264198017917 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198017918 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 264198017919 Helix-turn-helix domains; Region: HTH; cl00088 264198017920 EamA-like transporter family; Region: EamA; cl01037 264198017921 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 264198017922 EamA-like transporter family; Region: EamA; cl01037 264198017923 ferric uptake regulator; Provisional; Region: fur; PRK09462 264198017924 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 264198017925 metal binding site 2 [ion binding]; metal-binding site 264198017926 putative DNA binding helix; other site 264198017927 metal binding site 1 [ion binding]; metal-binding site 264198017928 dimer interface [polypeptide binding]; other site 264198017929 structural Zn2+ binding site [ion binding]; other site 264198017930 Cupin domain; Region: Cupin_2; cl09118 264198017931 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 264198017932 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264198017933 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 264198017934 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198017935 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 264198017936 Helix-turn-helix domains; Region: HTH; cl00088 264198017937 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198017938 dimerization interface [polypeptide binding]; other site 264198017939 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 264198017940 elongation factor G; Reviewed; Region: PRK00007 264198017941 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 264198017942 G1 box; other site 264198017943 putative GEF interaction site [polypeptide binding]; other site 264198017944 GTP/Mg2+ binding site [chemical binding]; other site 264198017945 Switch I region; other site 264198017946 G2 box; other site 264198017947 G3 box; other site 264198017948 Switch II region; other site 264198017949 G4 box; other site 264198017950 G5 box; other site 264198017951 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 264198017952 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 264198017953 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 264198017954 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198017955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198017956 active site 264198017957 phosphorylation site [posttranslational modification] 264198017958 intermolecular recognition site; other site 264198017959 dimerization interface [polypeptide binding]; other site 264198017960 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198017961 DNA binding residues [nucleotide binding] 264198017962 dimerization interface [polypeptide binding]; other site 264198017963 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 264198017964 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 264198017965 active site residue [active] 264198017966 Protein of unknown function (DUF1177); Region: DUF1177; pfam06675 264198017967 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198017968 trimer interface [polypeptide binding]; other site 264198017969 eyelet of channel; other site 264198017970 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 264198017971 active site pocket [active] 264198017972 oxyanion hole [active] 264198017973 catalytic triad [active] 264198017974 active site nucleophile [active] 264198017975 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 264198017976 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264198017977 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264198017978 catalytic residue [active] 264198017979 OPT oligopeptide transporter protein; Region: OPT; cl14607 264198017980 OPT oligopeptide transporter protein; Region: OPT; cl14607 264198017981 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198017982 Helix-turn-helix domains; Region: HTH; cl00088 264198017983 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198017984 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 264198017985 active site 264198017986 nucleophile elbow; other site 264198017987 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198017988 Helix-turn-helix domains; Region: HTH; cl00088 264198017989 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198017990 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 264198017991 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 264198017992 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 264198017993 Cache domain; Region: Cache_2; cl07034 264198017994 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 264198017995 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264198017996 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198017997 dimer interface [polypeptide binding]; other site 264198017998 putative CheW interface [polypeptide binding]; other site 264198017999 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 264198018000 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198018001 Walker A motif; other site 264198018002 ATP binding site [chemical binding]; other site 264198018003 Walker B motif; other site 264198018004 arginine finger; other site 264198018005 Helix-turn-helix domains; Region: HTH; cl00088 264198018006 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 264198018007 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 264198018008 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 264198018009 tetramer interface [polypeptide binding]; other site 264198018010 TPP-binding site [chemical binding]; other site 264198018011 heterodimer interface [polypeptide binding]; other site 264198018012 phosphorylation loop region [posttranslational modification] 264198018013 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 264198018014 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 264198018015 alpha subunit interface [polypeptide binding]; other site 264198018016 TPP binding site [chemical binding]; other site 264198018017 heterodimer interface [polypeptide binding]; other site 264198018018 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 264198018019 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 264198018020 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 264198018021 E3 interaction surface; other site 264198018022 lipoyl attachment site [posttranslational modification]; other site 264198018023 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264198018024 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 264198018025 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 264198018026 OsmC-like protein; Region: OsmC; cl00767 264198018027 O-methyltransferase; Region: Methyltransf_2; pfam00891 264198018028 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 264198018029 GIY-YIG motif/motif A; other site 264198018030 putative active site [active] 264198018031 putative metal binding site [ion binding]; other site 264198018032 OsmC-like protein; Region: OsmC; cl00767 264198018033 Transcriptional regulators [Transcription]; Region: MarR; COG1846 264198018034 Helix-turn-helix domains; Region: HTH; cl00088 264198018035 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 264198018036 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 264198018037 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 264198018038 protein binding site [polypeptide binding]; other site 264198018039 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 264198018040 protein binding site [polypeptide binding]; other site 264198018041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198018042 putative substrate translocation pore; other site 264198018043 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 264198018044 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198018045 Helix-turn-helix domains; Region: HTH; cl00088 264198018046 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 264198018047 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 264198018048 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 264198018049 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 264198018050 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 264198018051 MoxR-like ATPases [General function prediction only]; Region: COG0714 264198018052 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198018053 Walker A motif; other site 264198018054 ATP binding site [chemical binding]; other site 264198018055 Walker B motif; other site 264198018056 arginine finger; other site 264198018057 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 264198018058 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 264198018059 Helix-turn-helix domains; Region: HTH; cl00088 264198018060 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198018061 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 264198018062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198018063 putative substrate translocation pore; other site 264198018064 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198018065 Helix-turn-helix domains; Region: HTH; cl00088 264198018066 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198018067 putative effector binding pocket; other site 264198018068 dimerization interface [polypeptide binding]; other site 264198018069 YGGT family; Region: YGGT; cl00508 264198018070 YGGT family; Region: YGGT; cl00508 264198018071 Helix-turn-helix domains; Region: HTH; cl00088 264198018072 acyl-CoA synthetase; Validated; Region: PRK08316 264198018073 AMP-binding enzyme; Region: AMP-binding; cl15778 264198018074 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198018075 Dienelactone hydrolase family; Region: DLH; pfam01738 264198018076 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 264198018077 PLD-like domain; Region: PLDc_2; pfam13091 264198018078 putative active site [active] 264198018079 catalytic site [active] 264198018080 Dodecin; Region: Dodecin; cl01328 264198018081 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 264198018082 FIST N domain; Region: FIST; cl10701 264198018083 FIST C domain; Region: FIST_C; pfam10442 264198018084 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 264198018085 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 264198018086 active site 264198018087 metal binding site [ion binding]; metal-binding site 264198018088 DNA binding site [nucleotide binding] 264198018089 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 264198018090 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 264198018091 AAA domain; Region: AAA_23; pfam13476 264198018092 Walker A/P-loop; other site 264198018093 ATP binding site [chemical binding]; other site 264198018094 Q-loop/lid; other site 264198018095 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198018096 ABC transporter signature motif; other site 264198018097 Walker B; other site 264198018098 D-loop; other site 264198018099 H-loop/switch region; other site 264198018100 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 264198018101 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 264198018102 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 264198018103 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 264198018104 dimer interface [polypeptide binding]; other site 264198018105 active site 264198018106 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 264198018107 classical (c) SDRs; Region: SDR_c; cd05233 264198018108 NAD(P) binding site [chemical binding]; other site 264198018109 active site 264198018110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198018111 NMT1-like family; Region: NMT1_2; cl15260 264198018112 Helix-turn-helix domains; Region: HTH; cl00088 264198018113 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 264198018114 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 264198018115 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 264198018116 FMN binding site [chemical binding]; other site 264198018117 substrate binding site [chemical binding]; other site 264198018118 putative catalytic residue [active] 264198018119 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 264198018120 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 264198018121 Int/Topo IB signature motif; other site 264198018122 DNA binding site [nucleotide binding] 264198018123 active site 264198018124 UDP-glucose 4-epimerase; Region: PLN02240 264198018125 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 264198018126 NAD binding site [chemical binding]; other site 264198018127 homodimer interface [polypeptide binding]; other site 264198018128 active site 264198018129 substrate binding site [chemical binding]; other site 264198018130 H-NS histone family; Region: Histone_HNS; pfam00816 264198018131 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 264198018132 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264198018133 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 264198018134 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264198018135 dimerization interface [polypeptide binding]; other site 264198018136 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198018137 dimer interface [polypeptide binding]; other site 264198018138 putative CheW interface [polypeptide binding]; other site 264198018139 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198018140 metal binding site [ion binding]; metal-binding site 264198018141 active site 264198018142 I-site; other site 264198018143 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 264198018144 Response regulator receiver domain; Region: Response_reg; pfam00072 264198018145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198018146 active site 264198018147 phosphorylation site [posttranslational modification] 264198018148 intermolecular recognition site; other site 264198018149 dimerization interface [polypeptide binding]; other site 264198018150 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 264198018151 putative CheA interaction surface; other site 264198018152 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198018153 PAS fold; Region: PAS_3; pfam08447 264198018154 putative active site [active] 264198018155 heme pocket [chemical binding]; other site 264198018156 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264198018157 dimerization interface [polypeptide binding]; other site 264198018158 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264198018159 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198018160 dimer interface [polypeptide binding]; other site 264198018161 putative CheW interface [polypeptide binding]; other site 264198018162 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 264198018163 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264198018164 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198018165 dimer interface [polypeptide binding]; other site 264198018166 putative CheW interface [polypeptide binding]; other site 264198018167 Protein of unknown function (DUF4088); Region: DUF4088; pfam13317 264198018168 Flagellar transcriptional activator (FlhD); Region: FlhD; cl05012 264198018169 Flagellar transcriptional activator (FlhC); Region: FlhC; cl05036 264198018170 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 264198018171 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 264198018172 flagellar motor protein MotB; Validated; Region: motB; PRK09041 264198018173 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 264198018174 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264198018175 ligand binding site [chemical binding]; other site 264198018176 chemotaxis protein CheA; Provisional; Region: PRK10547 264198018177 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 264198018178 CheY binding; Region: CheY-binding; pfam09078 264198018179 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 264198018180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198018181 ATP binding site [chemical binding]; other site 264198018182 Mg2+ binding site [ion binding]; other site 264198018183 G-X-G motif; other site 264198018184 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 264198018185 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 264198018186 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 264198018187 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 264198018188 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198018189 S-adenosylmethionine binding site [chemical binding]; other site 264198018190 CheD chemotactic sensory transduction; Region: CheD; cl00810 264198018191 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 264198018192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198018193 active site 264198018194 phosphorylation site [posttranslational modification] 264198018195 intermolecular recognition site; other site 264198018196 dimerization interface [polypeptide binding]; other site 264198018197 CheB methylesterase; Region: CheB_methylest; pfam01339 264198018198 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 264198018199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198018200 active site 264198018201 phosphorylation site [posttranslational modification] 264198018202 intermolecular recognition site; other site 264198018203 dimerization interface [polypeptide binding]; other site 264198018204 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 264198018205 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 264198018206 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 264198018207 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 264198018208 FHIPEP family; Region: FHIPEP; pfam00771 264198018209 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723 264198018210 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198018211 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198018212 Walker A/P-loop; other site 264198018213 ATP binding site [chemical binding]; other site 264198018214 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 264198018215 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198018216 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 264198018217 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264198018218 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 264198018219 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264198018220 DNA binding residues [nucleotide binding] 264198018221 Flagellar protein FlhE; Region: FlhE; pfam06366 264198018222 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 264198018223 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198018224 FlgN protein; Region: FlgN; cl09176 264198018225 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 264198018226 SAF-like; Region: SAF_2; pfam13144 264198018227 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 264198018228 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 264198018229 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 264198018230 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 264198018231 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 264198018232 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 264198018233 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 264198018234 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 264198018235 FlgD Ig-like domain; Region: FlgD_ig; cl15790 264198018236 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 264198018237 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 264198018238 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 264198018239 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 264198018240 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 264198018241 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 264198018242 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 264198018243 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694 264198018244 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 264198018245 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 264198018246 Flagellar L-ring protein; Region: FlgH; cl00905 264198018247 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 264198018248 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 264198018249 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12712 264198018250 Rod binding protein; Region: Rod-binding; cl01626 264198018251 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 264198018252 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945 264198018253 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 264198018254 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 264198018255 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 264198018256 urocanate hydratase; Provisional; Region: PRK05414 264198018257 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 264198018258 active sites [active] 264198018259 tetramer interface [polypeptide binding]; other site 264198018260 putative proline-specific permease; Provisional; Region: proY; PRK10580 264198018261 Spore germination protein; Region: Spore_permease; cl15802 264198018262 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 264198018263 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264198018264 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198018265 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198018266 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198018267 Helix-turn-helix domains; Region: HTH; cl00088 264198018268 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 264198018269 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264198018270 Helix-turn-helix domains; Region: HTH; cl00088 264198018271 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 264198018272 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 264198018273 Na binding site [ion binding]; other site 264198018274 Protein of unknown function, DUF485; Region: DUF485; cl01231 264198018275 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198018276 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 264198018277 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198018278 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 264198018279 dimer interface [polypeptide binding]; other site 264198018280 putative metal binding site [ion binding]; other site 264198018281 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198018282 Helix-turn-helix domains; Region: HTH; cl00088 264198018283 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198018284 putative effector binding pocket; other site 264198018285 dimerization interface [polypeptide binding]; other site 264198018286 Fumarase C-terminus; Region: Fumerase_C; cl00795 264198018287 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 264198018288 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 264198018289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198018290 putative substrate translocation pore; other site 264198018291 Helix-turn-helix domains; Region: HTH; cl00088 264198018292 transcriptional activator TtdR; Provisional; Region: PRK09801 264198018293 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 264198018294 putative effector binding pocket; other site 264198018295 putative dimerization interface [polypeptide binding]; other site 264198018296 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264198018297 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 264198018298 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198018299 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 264198018300 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 264198018301 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 264198018302 FAD binding domain; Region: FAD_binding_4; pfam01565 264198018303 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 264198018304 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264198018305 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198018306 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 264198018307 tetramerization interface [polypeptide binding]; other site 264198018308 NAD(P) binding site [chemical binding]; other site 264198018309 catalytic residues [active] 264198018310 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 264198018311 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 264198018312 Helix-turn-helix domains; Region: HTH; cl00088 264198018313 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 264198018314 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264198018315 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 264198018316 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264198018317 inhibitor-cofactor binding pocket; inhibition site 264198018318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264198018319 catalytic residue [active] 264198018320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198018321 metabolite-proton symporter; Region: 2A0106; TIGR00883 264198018322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198018323 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 264198018324 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 264198018325 dimerization interface [polypeptide binding]; other site 264198018326 ligand binding site [chemical binding]; other site 264198018327 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 264198018328 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198018329 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 264198018330 cytosine deaminase; Validated; Region: PRK07572 264198018331 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198018332 Amidohydrolase; Region: Amidohydro_4; pfam13147 264198018333 active site 264198018334 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 264198018335 EamA-like transporter family; Region: EamA; cl01037 264198018336 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198018337 DNA-binding site [nucleotide binding]; DNA binding site 264198018338 FCD domain; Region: FCD; cl11656 264198018339 Activator of aromatic catabolism; Region: XylR_N; pfam06505 264198018340 Heme NO binding; Region: HNOB; cl15268 264198018341 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 264198018342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198018343 Walker A motif; other site 264198018344 ATP binding site [chemical binding]; other site 264198018345 Walker B motif; other site 264198018346 arginine finger; other site 264198018347 Helix-turn-helix domains; Region: HTH; cl00088 264198018348 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 264198018349 Activator of aromatic catabolism; Region: XylR_N; pfam06505 264198018350 Heme NO binding; Region: HNOB; cl15268 264198018351 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 264198018352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264198018353 Walker A motif; other site 264198018354 ATP binding site [chemical binding]; other site 264198018355 Walker B motif; other site 264198018356 Helix-turn-helix domains; Region: HTH; cl00088 264198018357 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 264198018358 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198018359 catalytic loop [active] 264198018360 iron binding site [ion binding]; other site 264198018361 Toluene-4-monoxygenase electron transfer component of Pseudomonas mendocina hydroxylates toluene and forms p-cresol as part of a three component toluene-4-monoxygenase system. Electron transfer is from NADH to an NADH:ferredoxin oxidoreductase (TmoF in P; Region: T4MO_e_transfer_like; cd06190 264198018362 FAD binding pocket [chemical binding]; other site 264198018363 FAD binding motif [chemical binding]; other site 264198018364 phosphate binding motif [ion binding]; other site 264198018365 beta-alpha-beta structure motif; other site 264198018366 NAD binding pocket [chemical binding]; other site 264198018367 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 264198018368 dimerization interface [polypeptide binding]; other site 264198018369 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 264198018370 Toluene-4-monooxygenase effector protein complex (T4mo), Rieske ferredoxin subunit; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. T4mo is a four-protein complex that catalyzes the NADH- and O2-dependent...; Region: Rieske_T4moC; cd03474 264198018371 [2Fe-2S] cluster binding site [ion binding]; other site 264198018372 Toluene-4-monooxygenase system protein B (TmoB); Region: TmoB; pfam06234 264198018373 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 264198018374 dinuclear metal binding motif [ion binding]; other site 264198018375 Phenol hydroxylase subunit; Region: Phenol_hyd_sub; pfam06099 264198018376 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 264198018377 dinuclear metal binding motif [ion binding]; other site 264198018378 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 264198018379 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 264198018380 dimerization interface [polypeptide binding]; other site 264198018381 putative path to active site cavity [active] 264198018382 diiron center [ion binding]; other site 264198018383 Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663 264198018384 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 264198018385 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198018386 catalytic loop [active] 264198018387 iron binding site [ion binding]; other site 264198018388 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 264198018389 FAD binding pocket [chemical binding]; other site 264198018390 conserved FAD binding motif [chemical binding]; other site 264198018391 phosphate binding motif [ion binding]; other site 264198018392 beta-alpha-beta structure motif; other site 264198018393 NAD binding pocket [chemical binding]; other site 264198018394 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198018395 catalytic loop [active] 264198018396 iron binding site [ion binding]; other site 264198018397 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 264198018398 N-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_N; cd07265 264198018399 tetramer interface [polypeptide binding]; other site 264198018400 C-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_C; cd07243 264198018401 tetramer interface [polypeptide binding]; other site 264198018402 active site 264198018403 Fe binding site [ion binding]; other site 264198018404 Domain of unknown function (DUF336); Region: DUF336; cl01249 264198018405 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198018406 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 264198018407 NAD binding site [chemical binding]; other site 264198018408 catalytic residues [active] 264198018409 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 264198018410 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 264198018411 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 264198018412 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 264198018413 active site 1 [active] 264198018414 dimer interface [polypeptide binding]; other site 264198018415 hexamer interface [polypeptide binding]; other site 264198018416 active site 2 [active] 264198018417 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 264198018418 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 264198018419 Helix-turn-helix domains; Region: HTH; cl00088 264198018420 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 264198018421 dimerization interface [polypeptide binding]; other site 264198018422 substrate binding pocket [chemical binding]; other site 264198018423 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 264198018424 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 264198018425 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 264198018426 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 264198018427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264198018428 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 264198018429 dimerization domain swap beta strand [polypeptide binding]; other site 264198018430 regulatory protein interface [polypeptide binding]; other site 264198018431 active site 264198018432 regulatory phosphorylation site [posttranslational modification]; other site 264198018433 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 264198018434 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 264198018435 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 264198018436 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 264198018437 Na binding site [ion binding]; other site 264198018438 Arginase family; Region: Arginase; cl00306 264198018439 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198018440 Helix-turn-helix domains; Region: HTH; cl00088 264198018441 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264198018442 dimerization interface [polypeptide binding]; other site 264198018443 Cupin domain; Region: Cupin_2; cl09118 264198018444 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 264198018445 SEC-C motif; Region: SEC-C; pfam02810 264198018446 Helix-turn-helix domains; Region: HTH; cl00088 264198018447 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198018448 trimer interface [polypeptide binding]; other site 264198018449 eyelet of channel; other site 264198018450 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 264198018451 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 264198018452 homotrimer interaction site [polypeptide binding]; other site 264198018453 putative active site [active] 264198018454 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 264198018455 benzoate transport; Region: 2A0115; TIGR00895 264198018456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198018457 putative substrate translocation pore; other site 264198018458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198018459 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 264198018460 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 264198018461 molybdopterin cofactor binding site [chemical binding]; other site 264198018462 substrate binding site [chemical binding]; other site 264198018463 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 264198018464 molybdopterin cofactor binding site; other site 264198018465 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 264198018466 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 264198018467 putative active site [active] 264198018468 putative substrate binding site [chemical binding]; other site 264198018469 ATP binding site [chemical binding]; other site 264198018470 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 264198018471 classical (c) SDRs; Region: SDR_c; cd05233 264198018472 NAD(P) binding site [chemical binding]; other site 264198018473 active site 264198018474 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 264198018475 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 264198018476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198018477 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 264198018478 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 264198018479 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 264198018480 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 264198018481 putative hydrophobic ligand binding site [chemical binding]; other site 264198018482 HTH-like domain; Region: HTH_21; pfam13276 264198018483 Integrase core domain; Region: rve; cl01316 264198018484 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 264198018485 putative acyl-acceptor binding pocket; other site 264198018486 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 264198018487 Protein required for attachment to host cells; Region: Host_attach; cl02398 264198018488 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 264198018489 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 264198018490 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 264198018491 NMT1-like family; Region: NMT1_2; cl15260 264198018492 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 264198018493 rRNA binding site [nucleotide binding]; other site 264198018494 predicted 30S ribosome binding site; other site 264198018495 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 264198018496 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 264198018497 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 264198018498 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198018499 Helix-turn-helix domains; Region: HTH; cl00088 264198018500 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198018501 dimerization interface [polypeptide binding]; other site 264198018502 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 264198018503 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 264198018504 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 264198018505 Na binding site [ion binding]; other site 264198018506 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 264198018507 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 264198018508 active site 264198018509 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 264198018510 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198018511 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 264198018512 Na+/H+ antiporter family; Region: Na_H_antiporter; cl15356 264198018513 ornithine cyclodeaminase; Validated; Region: PRK06141 264198018514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198018515 The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759 264198018516 putative [Fe4-S4] binding site [ion binding]; other site 264198018517 putative molybdopterin cofactor binding site [chemical binding]; other site 264198018518 The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759 264198018519 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 264198018520 putative molybdopterin cofactor binding site; other site 264198018521 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 264198018522 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 264198018523 FAD binding pocket [chemical binding]; other site 264198018524 FAD binding motif [chemical binding]; other site 264198018525 phosphate binding motif [ion binding]; other site 264198018526 beta-alpha-beta structure motif; other site 264198018527 NAD binding pocket [chemical binding]; other site 264198018528 Heme binding pocket [chemical binding]; other site 264198018529 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198018530 catalytic loop [active] 264198018531 iron binding site [ion binding]; other site 264198018532 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198018533 Helix-turn-helix domains; Region: HTH; cl00088 264198018534 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 264198018535 putative substrate binding pocket [chemical binding]; other site 264198018536 dimerization interface [polypeptide binding]; other site 264198018537 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 264198018538 Helix-turn-helix domains; Region: HTH; cl00088 264198018539 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 264198018540 putative dimerization interface [polypeptide binding]; other site 264198018541 choline-sulfatase; Region: chol_sulfatase; TIGR03417 264198018542 Sulfatase; Region: Sulfatase; cl10460 264198018543 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 264198018544 FAD binding domain; Region: FAD_binding_4; pfam01565 264198018545 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198018546 NMT1-like family; Region: NMT1_2; cl15260 264198018547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198018548 metabolite-proton symporter; Region: 2A0106; TIGR00883 264198018549 putative substrate translocation pore; other site 264198018550 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264198018551 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198018552 DNA-binding site [nucleotide binding]; DNA binding site 264198018553 FCD domain; Region: FCD; cl11656 264198018554 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198018555 trimer interface [polypeptide binding]; other site 264198018556 eyelet of channel; other site 264198018557 Flavin Reductases; Region: FlaRed; cl00801 264198018558 Dienelactone hydrolase family; Region: DLH; pfam01738 264198018559 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 264198018560 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 264198018561 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 264198018562 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 3-O-Methylgallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of 3-O-Methylgallate; Region: 3MGA_Dioxygenase; cd07366 264198018563 putative active site [active] 264198018564 putative Fe(II) binding site [ion binding]; other site 264198018565 putative dimer interface [polypeptide binding]; other site 264198018566 putative tetramer interface [polypeptide binding]; other site 264198018567 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198018568 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 264198018569 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 264198018570 FMN-binding pocket [chemical binding]; other site 264198018571 flavin binding motif; other site 264198018572 phosphate binding motif [ion binding]; other site 264198018573 beta-alpha-beta structure motif; other site 264198018574 NAD binding pocket [chemical binding]; other site 264198018575 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198018576 catalytic loop [active] 264198018577 iron binding site [ion binding]; other site 264198018578 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 264198018579 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl01922 264198018580 Asp-box motif; other site 264198018581 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264198018582 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264198018583 active site 264198018584 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 264198018585 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 264198018586 alpha subunit interface [polypeptide binding]; other site 264198018587 active site 264198018588 substrate binding site [chemical binding]; other site 264198018589 Fe binding site [ion binding]; other site 264198018590 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 264198018591 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198018592 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 264198018593 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 264198018594 NAD(P) binding site [chemical binding]; other site 264198018595 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 264198018596 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264198018597 active site 264198018598 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264198018599 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198018600 DNA-binding site [nucleotide binding]; DNA binding site 264198018601 FCD domain; Region: FCD; cl11656 264198018602 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198018603 trimer interface [polypeptide binding]; other site 264198018604 eyelet of channel; other site 264198018605 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 264198018606 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 264198018607 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 264198018608 iron-sulfur cluster [ion binding]; other site 264198018609 [2Fe-2S] cluster binding site [ion binding]; other site 264198018610 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 264198018611 alpha subunit interface [polypeptide binding]; other site 264198018612 active site 264198018613 substrate binding site [chemical binding]; other site 264198018614 Fe binding site [ion binding]; other site 264198018615 hypothetical protein; Validated; Region: PRK07121 264198018616 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198018617 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264198018618 putative substrate translocation pore; other site 264198018619 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 264198018620 Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can...; Region: MLE_like; cd03315 264198018621 active site 264198018622 H+ Antiporter protein; Region: 2A0121; TIGR00900 264198018623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198018624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198018625 Transcriptional regulators [Transcription]; Region: GntR; COG1802 264198018626 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198018627 DNA-binding site [nucleotide binding]; DNA binding site 264198018628 NMT1-like family; Region: NMT1_2; cl15260 264198018629 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 264198018630 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 264198018631 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 264198018632 Walker A/P-loop; other site 264198018633 ATP binding site [chemical binding]; other site 264198018634 Q-loop/lid; other site 264198018635 ABC transporter signature motif; other site 264198018636 Walker B; other site 264198018637 D-loop; other site 264198018638 H-loop/switch region; other site 264198018639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198018640 dimer interface [polypeptide binding]; other site 264198018641 conserved gate region; other site 264198018642 putative PBP binding loops; other site 264198018643 ABC-ATPase subunit interface; other site 264198018644 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 264198018645 Cupin domain; Region: Cupin_2; cl09118 264198018646 Cupin domain; Region: Cupin_2; cl09118 264198018647 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 264198018648 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 264198018649 maleylacetoacetate isomerase; Region: maiA; TIGR01262 264198018650 C-terminal domain interface [polypeptide binding]; other site 264198018651 GSH binding site (G-site) [chemical binding]; other site 264198018652 putative dimer interface [polypeptide binding]; other site 264198018653 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 264198018654 dimer interface [polypeptide binding]; other site 264198018655 N-terminal domain interface [polypeptide binding]; other site 264198018656 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 264198018657 salicylate hydroxylase; Provisional; Region: PRK08163 264198018658 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198018659 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 264198018660 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 264198018661 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264198018662 C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343 264198018663 active site 264198018664 metal binding site [ion binding]; metal-binding site 264198018665 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 264198018666 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198018667 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198018668 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198018669 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 264198018670 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 264198018671 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 264198018672 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198018673 Helix-turn-helix domains; Region: HTH; cl00088 264198018674 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198018675 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 264198018676 Helix-turn-helix domains; Region: HTH; cl00088 264198018677 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198018678 dimerization interface [polypeptide binding]; other site 264198018679 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 264198018680 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 264198018681 metal binding site [ion binding]; metal-binding site 264198018682 putative dimer interface [polypeptide binding]; other site 264198018683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198018684 metabolite-proton symporter; Region: 2A0106; TIGR00883 264198018685 putative substrate translocation pore; other site 264198018686 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 264198018687 amino acid transporter; Region: 2A0306; TIGR00909 264198018688 Spore germination protein; Region: Spore_permease; cl15802 264198018689 Spore germination protein; Region: Spore_permease; cl15802 264198018690 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 264198018691 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 264198018692 NAD binding site [chemical binding]; other site 264198018693 Phe binding site; other site 264198018694 Bacterial transcriptional activator domain; Region: BTAD; smart01043 264198018695 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 264198018696 cyclase homology domain; Region: CHD; cd07302 264198018697 dimer interface [polypeptide binding]; other site 264198018698 nucleotidyl binding site; other site 264198018699 metal binding site [ion binding]; metal-binding site 264198018700 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198018701 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 264198018702 Helix-turn-helix domains; Region: HTH; cl00088 264198018703 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 264198018704 Transcriptional regulator [Transcription]; Region: IclR; COG1414 264198018705 Helix-turn-helix domains; Region: HTH; cl00088 264198018706 Bacterial transcriptional regulator; Region: IclR; pfam01614 264198018707 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 264198018708 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 264198018709 active site 264198018710 catalytic residues [active] 264198018711 metal binding site [ion binding]; metal-binding site 264198018712 DmpG-like communication domain; Region: DmpG_comm; pfam07836 264198018713 acetaldehyde dehydrogenase; Validated; Region: PRK08300 264198018714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198018715 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 264198018716 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264198018717 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 264198018718 DEAD_2; Region: DEAD_2; pfam06733 264198018719 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198018720 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 264198018721 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198018722 tetrameric interface [polypeptide binding]; other site 264198018723 NAD binding site [chemical binding]; other site 264198018724 catalytic residues [active] 264198018725 Helix-turn-helix domains; Region: HTH; cl00088 264198018726 transcriptional activator TtdR; Provisional; Region: PRK09801 264198018727 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 264198018728 putative effector binding pocket; other site 264198018729 dimerization interface [polypeptide binding]; other site 264198018730 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 264198018731 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 264198018732 FMN-binding pocket [chemical binding]; other site 264198018733 flavin binding motif; other site 264198018734 phosphate binding motif [ion binding]; other site 264198018735 beta-alpha-beta structure motif; other site 264198018736 NAD binding pocket [chemical binding]; other site 264198018737 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 264198018738 catalytic loop [active] 264198018739 iron binding site [ion binding]; other site 264198018740 Amino acid permease; Region: AA_permease_2; pfam13520 264198018741 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 264198018742 choline dehydrogenase; Validated; Region: PRK02106 264198018743 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198018744 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 264198018745 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 264198018746 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198018747 tetramerization interface [polypeptide binding]; other site 264198018748 NAD(P) binding site [chemical binding]; other site 264198018749 catalytic residues [active] 264198018750 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 264198018751 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 264198018752 [2Fe-2S] cluster binding site [ion binding]; other site 264198018753 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 264198018754 putative alpha subunit interface [polypeptide binding]; other site 264198018755 putative active site [active] 264198018756 putative substrate binding site [chemical binding]; other site 264198018757 Fe binding site [ion binding]; other site 264198018758 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 264198018759 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264198018760 non-specific DNA binding site [nucleotide binding]; other site 264198018761 salt bridge; other site 264198018762 sequence-specific DNA binding site [nucleotide binding]; other site 264198018763 putative diguanylate cyclase; Provisional; Region: PRK09776 264198018764 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 264198018765 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198018766 PAS fold; Region: PAS_3; pfam08447 264198018767 putative active site [active] 264198018768 heme pocket [chemical binding]; other site 264198018769 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 264198018770 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264198018771 ligand binding site [chemical binding]; other site 264198018772 flexible hinge region; other site 264198018773 Helix-turn-helix domains; Region: HTH; cl00088 264198018774 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264198018775 Helix-turn-helix domains; Region: HTH; cl00088 264198018776 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 264198018777 putative substrate binding pocket [chemical binding]; other site 264198018778 dimerization interface [polypeptide binding]; other site 264198018779 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 264198018780 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 264198018781 dimer interface [polypeptide binding]; other site 264198018782 PYR/PP interface [polypeptide binding]; other site 264198018783 TPP binding site [chemical binding]; other site 264198018784 substrate binding site [chemical binding]; other site 264198018785 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 264198018786 TPP-binding site [chemical binding]; other site 264198018787 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 264198018788 DoxX; Region: DoxX; cl00976 264198018789 polyphosphate kinase; Provisional; Region: PRK05443 264198018790 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 264198018791 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 264198018792 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 264198018793 putative active site [active] 264198018794 catalytic site [active] 264198018795 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 264198018796 putative domain interface [polypeptide binding]; other site 264198018797 putative active site [active] 264198018798 catalytic site [active] 264198018799 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264198018800 PAS domain; Region: PAS_9; pfam13426 264198018801 putative active site [active] 264198018802 heme pocket [chemical binding]; other site 264198018803 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 264198018804 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264198018805 dimer interface [polypeptide binding]; other site 264198018806 phosphorylation site [posttranslational modification] 264198018807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264198018808 ATP binding site [chemical binding]; other site 264198018809 Mg2+ binding site [ion binding]; other site 264198018810 G-X-G motif; other site 264198018811 Response regulator receiver domain; Region: Response_reg; pfam00072 264198018812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198018813 active site 264198018814 phosphorylation site [posttranslational modification] 264198018815 intermolecular recognition site; other site 264198018816 dimerization interface [polypeptide binding]; other site 264198018817 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264198018818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264198018819 active site 264198018820 phosphorylation site [posttranslational modification] 264198018821 intermolecular recognition site; other site 264198018822 dimerization interface [polypeptide binding]; other site 264198018823 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264198018824 DNA binding residues [nucleotide binding] 264198018825 dimerization interface [polypeptide binding]; other site 264198018826 Haemagglutinin; Region: HIM; pfam05662 264198018827 YadA-like C-terminal region; Region: YadA; pfam03895 264198018828 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 264198018829 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 264198018830 ligand binding site [chemical binding]; other site 264198018831 Transcriptional regulators [Transcription]; Region: PurR; COG1609 264198018832 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 264198018833 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 264198018834 dimerization interface [polypeptide binding]; other site 264198018835 ligand binding site [chemical binding]; other site 264198018836 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 264198018837 NMT1-like family; Region: NMT1_2; cl15260 264198018838 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 264198018839 trimer interface [polypeptide binding]; other site 264198018840 eyelet of channel; other site 264198018841 Cupin domain; Region: Cupin_2; cl09118 264198018842 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 264198018843 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 264198018844 NAD(P) binding site [chemical binding]; other site 264198018845 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 264198018846 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 264198018847 classical (c) SDRs; Region: SDR_c; cd05233 264198018848 NAD(P) binding site [chemical binding]; other site 264198018849 active site 264198018850 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 264198018851 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 264198018852 active site 264198018853 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 264198018854 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 264198018855 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 264198018856 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 264198018857 Walker A/P-loop; other site 264198018858 ATP binding site [chemical binding]; other site 264198018859 Q-loop/lid; other site 264198018860 ABC transporter signature motif; other site 264198018861 Walker B; other site 264198018862 D-loop; other site 264198018863 H-loop/switch region; other site 264198018864 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264198018865 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 264198018866 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264198018867 FtsX-like permease family; Region: FtsX; cl15850 264198018868 benzoate transport; Region: 2A0115; TIGR00895 264198018869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198018870 putative substrate translocation pore; other site 264198018871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264198018872 salicylate hydroxylase; Provisional; Region: PRK08163 264198018873 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198018874 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 264198018875 maleylacetoacetate isomerase; Region: maiA; TIGR01262 264198018876 C-terminal domain interface [polypeptide binding]; other site 264198018877 GSH binding site (G-site) [chemical binding]; other site 264198018878 putative dimer interface [polypeptide binding]; other site 264198018879 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 264198018880 dimer interface [polypeptide binding]; other site 264198018881 N-terminal domain interface [polypeptide binding]; other site 264198018882 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 264198018883 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 264198018884 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 264198018885 Cupin domain; Region: Cupin_2; cl09118 264198018886 Cupin domain; Region: Cupin_2; cl09118 264198018887 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 264198018888 Helix-turn-helix domains; Region: HTH; cl00088 264198018889 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198018890 dimerization interface [polypeptide binding]; other site 264198018891 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 264198018892 homotrimer interaction site [polypeptide binding]; other site 264198018893 putative active site [active] 264198018894 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 264198018895 I-site; other site 264198018896 active site 264198018897 metal binding site [ion binding]; metal-binding site 264198018898 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264198018899 dimerization interface [polypeptide binding]; other site 264198018900 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 264198018901 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 264198018902 dimer interface [polypeptide binding]; other site 264198018903 putative CheW interface [polypeptide binding]; other site 264198018904 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 264198018905 hypothetical protein; Reviewed; Region: PRK09588 264198018906 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198018907 FAD dependent oxidoreductase; Region: DAO; pfam01266 264198018908 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 264198018909 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264198018910 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264198018911 catalytic residue [active] 264198018912 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 264198018913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198018914 dimer interface [polypeptide binding]; other site 264198018915 conserved gate region; other site 264198018916 putative PBP binding loops; other site 264198018917 ABC-ATPase subunit interface; other site 264198018918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264198018919 dimer interface [polypeptide binding]; other site 264198018920 conserved gate region; other site 264198018921 putative PBP binding loops; other site 264198018922 ABC-ATPase subunit interface; other site 264198018923 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 264198018924 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264198018925 Walker A/P-loop; other site 264198018926 ATP binding site [chemical binding]; other site 264198018927 Q-loop/lid; other site 264198018928 ABC transporter signature motif; other site 264198018929 Walker B; other site 264198018930 D-loop; other site 264198018931 H-loop/switch region; other site 264198018932 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 264198018933 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264198018934 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264198018935 DNA-binding site [nucleotide binding]; DNA binding site 264198018936 FCD domain; Region: FCD; cl11656 264198018937 Sulfatase; Region: Sulfatase; cl10460 264198018938 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 264198018939 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264198018940 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 264198018941 NAD(P) binding site [chemical binding]; other site 264198018942 catalytic residues [active] 264198018943 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 264198018944 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 264198018945 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198018946 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264198018947 NAD(P) binding pocket [chemical binding]; other site 264198018948 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 264198018949 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 264198018950 FliP family; Region: FliP; cl00593 264198018951 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 264198018952 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 264198018953 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 264198018954 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 264198018955 Flagellar basal body-associated protein FliL; Region: FliL; cl00681