-- dump date 20120504_160152 -- class Genbank::CDS -- table cds_note -- id note NP_443803.1 y4cK; NGR234_46 NP_443802.1 y4cJ; NGR234_45 NP_443801.1 y4cI; NGR234_44 NP_443800.1 y4cH; NGR234_43 NP_443799.1 y4cG; NGR234_42 NP_443798.1 y4cF; NGR234_41 NP_443797.1 y4cE; NGR234_40 NP_443796.1 y4cD; NGR234_39 NP_443795.1 y4cC; NGR234_38 NP_443794.1 y4cB; NGR234_37 NP_443793.1 y4cA; NGR234_36 NP_443792.1 y4bO; NGR234_35 NP_443791.1 y4bN; NGR234_34 NP_444068.1 y4bM; NGR234_33 NP_443789.1 y4bL; NGR234_32 NP_443788.1 y4bK; NGR234_31 NP_443787.1 y4bJ; NGR234_30 NP_443786.1 y4bI; NGR234_29 NP_443785.1 y4bH; NGR234_28 NP_443784.1 y4bG; NGR234_27 NP_443783.1 y4bF; NGR234_26 NP_443782.1 y4bD; NGR234_24 NP_443781.1 y4bC; NGR234_23 NP_443780.1 y4bB; NGR234_22 NP_444021.1 y4bA; NGR234_21 NP_443778.1 y4aS; NGR234_19 NP_443777.1 y4aR; NGR234_18 NP_443776.1 y4aQ; NGR234_17 NP_443775.1 mucR; NGR234_16 NP_443774.1 y4aO; NGR234_15 NP_443773.1 y4aN; NGR234_14 NP_443771.1 nodD1; NGR234_12 NP_443770.1 y4aK; NGR234_11 NP_443769.1 noeJ; NGR234_10 NP_443767.1 nodZ; NGR234_8 NP_443766.1 noeL; NGR234_7 NP_443765.1 y4aF; NGR234_6 NP_443764.1 y4aD; NGR234_4 NP_443763.1 y4aC; NGR234_3 NP_443762.1 similar to phytoene dehydrogenase; y4aB; NGR234_2 NP_443761.1 y4aA; NGR234_1 NP_444176.1 syrM2; NGR234_483 NP_444175.1 y4zD; NGR234_480 NP_444174.1 y4zC; NGR234_479 NP_444173.1 y4zB; NGR234_477 NP_444171.1 y4yS; NGR234_475 NP_444170.1 y4yR; NGR234_474 NP_444169.1 y4yQ; NGR234_473 YP_003097668.1 nopC; YP_052972.1; NGR234_471 NP_444168.1 y4yP; NGR234_470 NP_444167.1 y4yO; NGR234_469 NP_444166.1 y4yN; NGR234_468 NP_444165.1 y4yM; NGR234_467 NP_444164.1 part of a set of proteins involved in the infection of eukaryotic cells; in plant pathogens involved in the hypersensitivity response NP_444163.1 y4yK; NGR234_465 NP_444162.1 y4yJ; NGR234_464 NP_444161.1 y4yI; NGR234_463 NP_444160.1 nolV; NGR234_462 NP_444159.1 nolU; NGR234_461 NP_444158.1 nolT; NGR234_460 NP_444157.1 nolB; NGR234_459 NP_444156.1 nolW; NGR234_458 NP_444155.1 nolX; NGR234_457 NP_444154.1 y4yB; NGR234_456 NP_444153.1 y4yA; NGR234_455 NP_444152.1 y4xP; NGR234_454 NP_444151.1 y4xO; NGR234_453 NP_444150.1 y4xN; NGR234_452 NP_444149.1 y4xM; NGR234_451 NP_444148.1 y4xL; NGR234_450 NP_444147.1 similar to pilus assembly protein; y4xK; NGR234_449 NP_444146.1 y4xJ; NGR234_448 NP_444145.1 y4xI; NGR234_447 NP_444144.1 nodD2; NGR234_446 NP_444143.1 similar to tryptophan halogenase; y4xG; NGR234_445 NP_444142.1 similar to SyrA; y4xQ; NGR234_444 NP_444141.1 y4xF; NGR234_443 NP_444140.1 y4xE; NGR234_442 NP_444139.1 similar to y4vQ; y4xD; NGR234_441 NP_444114.1 nifK2; NGR234_440 NP_444137.1 nifD2; NGR234_439 NP_444136.1 nitrogenase iron protein; nitrogenase component 2; with component 1, an molybdenum-iron protein, catalyzes the fixation of nitrogen to ammonia; nitrogen reductase provides electrons to the nitrogenase complex; in R. etli there are three essentially identical copies of nifH which are actively expressed during symbiosis NP_444135.1 y4wP; NGR234_437 NP_444134.1 y4wO; NGR234_436 NP_444133.1 y4wM; NGR234_434 NP_444132.1 nifS; NGR234_433 NP_444131.1 associates with NifD and may protect the nitrogenase Fe-Mo protein from oxidative damage NP_444130.1 y4wJ; NGR234_431 NP_444129.1 y4wI; NGR234_430 NP_444128.1 similar to VirK of Agrobacterium tumefaciens; y4wH; NGR234_429 NP_444127.1 y4wG; NGR234_428 NP_444126.1 y4wF; NGR234_427 NP_444125.1 y4wE; NGR234_426 NP_444124.1 y4wD; NGR234_425 NP_444123.1 similar to y4aM; y4wC; NGR234_424 NP_444122.1 y4wB; NGR234_423 NP_444121.1 y4wA; NGR234_422 NP_444120.1 fdxB; NGR234_421 NP_444119.1 similar to N-terminus of NifH; y4vR; NGR234_420 NP_444118.1 similar to y4xD; y4vQ; NGR234_419 NP_444117.1 nifX; NGR234_418 NP_444116.1 functions with NifE to assemble FeMo cofactor; functions in assembly of nitrogenase MoFe NP_444115.1 functions with NifN to assemble FeMo cofactor; functions in assembly of nitrogenase MoFe NP_444138.1 nifK1; NGR234_415 NP_444113.1 nifD1; NGR234_414 NP_444112.1 nitrogenase iron protein; nitrogenase component 2; with component 1, an molybdenum-iron protein, catalyzes the fixation of nitrogen to ammonia; nitrogen reductase provides electrons to the nitrogenase complex; in R. etli there are three essentially identical copies of nifH which are actively expressed during symbiosis NP_444111.1 y4vJ; NGR234_412 NP_444110.1 y4vI; NGR234_411 NP_444109.1 y4vH; NGR234_410 NP_444108.1 y4vG; NGR234_409 NP_444107.1 involved in the transport of C4-dicarboxylates across the membrane NP_444106.1 nifQ; NGR234_407 NP_444105.1 y4vD; NGR234_406 NP_444104.1 y4vC; NGR234_405 NP_444103.1 fixA; NGR234_403 NP_444102.1 fixB; NGR234_402 NP_444101.1 fixC; NGR234_401 NP_444099.1 nifA; NGR234_399 NP_444097.1 fdxN; NGR234_397 NP_444096.1 nifZ; NGR234_396 NP_444095.1 fixU; NGR234_395 NP_444094.1 y4uI; NGR234_393 NP_444093.1 y4uH; NGR234_392 NP_444092.1 y4uG; NGR234_391 NP_444091.1 y4uF; NGR234_389 NP_444090.1 y4uE; NGR234_388 NP_444089.1 y4uD; NGR234_387 NP_444088.1 y4uC; NGR234_384 NP_444087.1 y4uB; NGR234_383 NP_444086.1 y4uA; NGR234_382 NP_444085.1 y4tS; NGR234_381 NP_444084.1 y4tR; NGR234_380 NP_444083.1 y4tQ; NGR234_379 NP_444082.1 y4tP; NGR234_378 NP_444081.1 y4tO; NGR234_377 NP_444080.1 y4tN; NGR234_376 NP_444079.1 y4tM; NGR234_375 NP_444078.1 y4tL; NGR234_374 NP_444077.1 cyclodeaminase NP_444076.1 catalyzes the formation of 2-oxobutanoate from L-threonine; involved in ectoine utilization NP_444075.1 y4tI; NGR234_371 NP_444074.1 y4tH; NGR234_370 NP_444073.1 y4tG; NGR234_369 NP_444072.1 y4tF; NGR234_368 NP_444071.1 y4tE; NGR234_367 NP_444070.1 y4tD; NGR234_366 NP_443939.1 y4tB; NGR234_364 NP_443790.1 y4tA; NGR234_363 NP_444066.1 y4sN; NGR234_359 NP_444065.1 y4sM; NGR234_358 NP_444064.1 y4sL; NGR234_357 NP_444063.1 y4sK; NGR234_356 NP_444062.1 gabD; NGR234_355 NP_444061.1 y4sI; NGR234_354 NP_444060.1 y4sH; NGR234_350 NP_444059.1 y4sG; NGR234_349 NP_444058.1 y4sE; NGR234_347 NP_444057.1 y4sD; NGR234_346 NP_444020.1 y4sC; NGR234_345 NP_444055.1 y4sB; NGR234_344 NP_444054.1 y4sA; NGR234_343 NP_444053.1 similar to y4qD; y4rO; NGR234_341 NP_444052.1 y4rN; NGR234_340 NP_444051.1 y4rM; NGR234_339 NP_444050.1 y4rL; NGR234_338 NP_444048.1 y4rJ; NGR234_336 NP_444046.1 y4rH; NGR234_331 NP_444045.1 y4rG; NGR234_330 NP_444044.1 y4rF; NGR234_329 NP_444043.1 y4rE; NGR234_328 NP_444042.1 y4rD; NGR234_327 NP_444041.1 y4rC; NGR234_326 NP_444040.1 y4rB; NGR234_325 NP_444039.1 y4rA; NGR234_324 NP_444038.1 y4qK; NGR234_322 NP_444037.1 y4qJ; NGR234_321 NP_444036.1 y4qI; NGR234_319 NP_444035.1 y4qH; NGR234_318 NP_444034.1 catalyzes the reversible formation of diaminobutyrate and 2-oxoglutarate from glutamate and L-aspartic beta-semialdehyde NP_444033.1 similar to y4sO; y4qF; NGR234_316 NP_444032.1 y4qE; NGR234_314 NP_444031.1 similar to N-terminus of y4rO; y4qD; NGR234_313 NP_444030.1 similar to y4oA; y4qC; NGR234_312 NP_444029.1 y4qB; NGR234_311 NP_444028.1 y4pO; NGR234_308 NP_444027.1 syrM1; NGR234_306 NP_444026.1 y4pM; NGR234_304 NP_444025.1 y4pL; NGR234_303 NP_444024.1 y4pK; NGR234_301 NP_444023.1 y4pJ; NGR234_300 NP_444022.1 y4pI; NGR234_299 NP_443779.1 y4pH; NGR234_298 NP_444056.1 y4pG; NGR234_296 NP_444019.1 y4pF; NGR234_295 NP_444018.1 y4pE; NGR234_294 NP_444017.1 y4pD; NGR234_293 NP_444016.1 otsA; NGR234_290 NP_444015.1 otsB; NGR234_289 NP_444014.1 y4pA; NGR234_288 NP_444013.1 y4oX; NGR234_287 NP_444012.1 y4oW; NGR234_286 NP_444011.1 y4oV; NGR234_285 NP_444010.1 y4oU; NGR234_284 NP_444009.1 y4oT; NGR234_283 NP_444008.1 y4oS; NGR234_282 NP_444007.1 y4oR; NGR234_281 NP_444006.1 y4oQ; NGR234_280 NP_444005.1 y4oP; NGR234_279 NP_444004.1 similar to NGRIS-4 family; y4oN; NGR234_277 NP_444003.1 similar to NGRIS-4 family; y4oM; NGR234_276 NP_444002.1 similar to NGRIS-4 family; y4oL; NGR234_275 NP_444001.1 y4oE; NGR234_268 NP_444000.1 y4oD; NGR234_267 NP_443999.1 y4oC; NGR234_266 NP_443998.1 y4oB; NGR234_265 NP_443997.1 similar to y4qC; y4oA; NGR234_264 NP_443996.1 y4nM; NGR234_263 NP_443995.1 y4nL; NGR234_262 NP_443994.1 y4nK; NGR234_261 NP_443993.1 y4nJ; NGR234_260 NP_443992.1 y4nI; NGR234_259 NP_443991.1 y4nH; NGR234_258 NP_443990.1 y4nG; NGR234_257 NP_443989.1 y4nF; NGR234_255 NP_443911.1 y4nE; NGR234_253 NP_443910.1 y4nD; NGR234_252 NP_443986.1 nodS; NGR234_251 NP_443985.1 nodU; NGR234_250 NP_443984.1 y4nA; NGR234_249 NP_443983.1 y4mQ; NGR234_248 NP_443982.1 y4mP; NGR234_247 NP_443981.1 y4mO; NGR234_246 NP_443980.1 y4mN; NGR234_245 NP_443979.1 y4mM; NGR234_244 NP_443978.1 y4mL; NGR234_243 NP_443977.1 y4mK; NGR234_242 NP_443976.1 y4mJ; NGR234_241 NP_443975.1 y4mI; NGR234_240 NP_443974.1 y4mH; NGR234_239 NP_443973.1 y4mG; NGR234_238 NP_443972.1 y4mF; NGR234_237 NP_443971.1 y4mE; NGR234_236 NP_443970.1 y4mD; NGR234_235 NP_443969.1 y4mC; NGR234_234 NP_443968.1 y4mB; NGR234_233 NP_443967.1 y4mA; NGR234_231 NP_443966.1 y4lS; NGR234_230 NP_443965.1 y4lR; NGR234_229 NP_443964.1 y4lO; NGR234_226 NP_443963.1 y4lN; NGR234_225 NP_443962.1 y4lL; NGR234_223 NP_443961.1 y4lK; NGR234_222 NP_443960.1 y4lJ; NGR234_220 NP_443959.1 y4lI; NGR234_219 NP_443958.1 y4lH; NGR234_218 NP_443957.1 y4lG; NGR234_217 NP_443956.1 y4lF; NGR234_216 NP_443955.1 y4lD; NGR234_213 NP_443954.1 y4lC; NGR234_212 NP_443953.1 y4lB; NGR234_211 NP_443952.1 y4lA; NGR234_210 NP_443951.1 y4kV; NGR234_209 NP_443950.1 y4kU; NGR234_208 NP_443949.1 y4kT; NGR234_207 NP_443948.1 y4kS; NGR234_206 NP_443947.1 y4kR; NGR234_205 NP_443946.1 y4kQ; NGR234_203 NP_443945.1 similar to StbE; possibly involved in symbiotic plasmid stability; y4kP; NGR234_202 NP_443944.1 y4kO; NGR234_201 NP_443943.1 y4kN; NGR234_200 NP_443942.1 y4kM; NGR234_199 NP_443941.1 y4kL; NGR234_198 NP_443940.1 y4kK; NGR234_197 NP_444069.1 y4kJ; NGR234_196 NP_443938.1 y4kI; NGR234_195 NP_443937.1 y4kH; NGR234_194 NP_443936.1 y4kG; NGR234_193 NP_443935.1 y4kF; NGR234_192 NP_443934.1 y4kE; NGR234_191 NP_443933.1 y4kD; NGR234_190 NP_443932.1 y4kB; NGR234_188 NP_443931.1 y4kA; NGR234_187 NP_443930.1 y4jT; NGR234_186 NP_443929.1 y4jS; NGR234_185 NP_443928.1 y4jR; NGR234_184 NP_443927.1 y4jQ; NGR234_183 NP_443925.1 y4jO; NGR234_181 NP_443924.1 y4jN; NGR234_180 NP_443922.1 y4jL; NGR234_178 NP_443921.1 y4jK; NGR234_177 NP_443920.1 y4jJ; NGR234_176 NP_443919.1 y4jI; NGR234_175 NP_443918.1 y4jH; NGR234_174 NP_443917.1 y4jG; NGR234_173 NP_443916.1 y4jF; NGR234_172 NP_443915.1 y4jE; NGR234_171 NP_443914.1 y4jD; NGR234_170 NP_443913.1 y4jC; NGR234_169 NP_443912.1 y4jB; NGR234_168 NP_443988.1 y4jA; NGR234_167 NP_443987.1 y4iQ; NGR234_166 NP_443907.1 y4iN; NGR234_163 NP_443906.1 y4iM; NGR234_162 NP_443905.1 y4iL; NGR234_161 NP_443904.1 y4iK; NGR234_160 NP_443903.1 y4iJ; NGR234_159 NP_443902.1 y4iI; NGR234_158 NP_443901.1 y4iH; NGR234_157 NP_443899.1 y4iF; NGR234_155 NP_443897.1 y4iD; NGR234_153 NP_443896.1 y4iC; NGR234_152 NP_443895.1 y4iR; NGR234_151 NP_443894.1 y4hR; NGR234_147 NP_443893.1 y4hQ; NGR234_146 NP_443892.1 y4hP; NGR234_145 NP_443891.1 y4hO; NGR234_144 NP_443890.1 y4hN; NGR234_143 NP_443889.1 y4hM; NGR234_142 NP_443888.1 y4hL; NGR234_141 NP_443887.1 y4hK; NGR234_140 NP_443886.1 similar to N-terminus of coproporphyrinogen III dehydrogenase; y4hJ; NGR234_139 NP_443885.1 catalyzes the transfer of a fatty acyl group onto Nod factor, beta-(1,4)-N-acetylglucosamine oligosaccharide NP_443884.1 nodB; NGR234_137 NP_443883.1 nodC; NGR234_136 NP_443882.1 ATP-binding subunit; with NodJ is involved in the export of lipo-chitin oligosaccharide; involved in nodulation induction NP_443879.1 noeI; NGR234_132 NP_443878.1 noeE; NGR234_131 NP_443876.1 y4gN; NGR234_129 NP_443875.1 y4gM; NGR234_128 NP_443874.1 y4gL; NGR234_127 NP_443873.1 fixF; NGR234_126 NP_443872.1 y4gJ; NGR234_125 NP_443871.1 y4gI; NGR234_124 NP_443870.1 y4gH; NGR234_123 NP_443869.1 y4gG; NGR234_122 NP_443868.1 y4gF; NGR234_121 NP_443867.1 y4gE; NGR234_120 NP_443865.1 y4gC; NGR234_118 NP_443864.1 y4gB; NGR234_117 NP_443863.1 y4gA; NGR234_116 NP_443862.1 y4fR; NGR234_115 NP_443861.1 y4fQ; NGR234_114 NP_443860.1 y4fP; NGR234_113 NP_443859.1 y4fO; NGR234_112 NP_443858.1 y4fN; NGR234_111 NP_443857.1 y4fM; NGR234_110 NP_443856.1 y4fL; NGR234_109 NP_443855.1 y4fK; NGR234_108 NP_443854.1 y4fJ; NGR234_107 NP_443853.1 y4fH; NGR234_105 NP_443852.1 y4fG; NGR234_104 NP_443851.1 y4fF; NGR234_103 NP_443850.1 y4fE; NGR234_102 NP_443849.1 y4fD; NGR234_101 NP_443847.1 y4fB; NGR234_99 NP_443846.1 y4fA; NGR234_98 NP_443845.1 y4eO; NGR234_97 NP_443844.1 y4eN; NGR234_96 NP_443843.1 y4eL; NGR234_93 NP_443842.1 y4eK; NGR234_92 NP_443841.1 y4eI; NGR234_90 NP_443840.1 nolL; NGR234_89 NP_443838.1 y4eE; NGR234_84 NP_443837.1 y4eD; NGR234_83 NP_443836.1 y4eC; NGR234_82 NP_443835.1 y4eB; NGR234_80 NP_443834.1 y4eA; NGR234_79 NP_443833.1 y4dX; NGR234_78 NP_443832.1 y4dW; NGR234_77 NP_443831.1 VirD4 family NP_443830.1 traD; NGR234_74 NP_443829.1 traC; NGR234_73 NP_443828.1 conjugal transfer system TraA; oriT nicking enzyme NP_443827.1 traF; NGR234_71 NP_443826.1 traB; NGR234_70 NP_443825.1 y4dP; NGR234_69 NP_443823.1 y4dN; NGR234_67 NP_443822.1 y4dM; NGR234_66 NP_443821.1 y4dL; NGR234_65 NP_443819.1 y4dJ; NGR234_62 NP_443818.1 traM; NGR234_61 NP_443817.1 traR; NGR234_60 NP_443816.1 trbI; NGR234_59 NP_443815.1 trbH; NGR234_58 NP_443814.1 trbG; NGR234_57 NP_443813.1 trbF; NGR234_56 NP_443812.1 trbL; NGR234_55 NP_443811.1 trbK; NGR234_54 NP_443810.1 trbJ; NGR234_53 NP_443809.1 trbEb; NGR234_52 NP_443808.1 trbEa; NGR234_51 NP_443807.1 trbD; NGR234_50 NP_443806.1 trbC; NGR234_49 NP_443805.1 VirB11 family protein; ATPase NP_443804.1 traI; NGR234_47 YP_002822240.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport YP_002822247.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_002822253.1 similar to carboxyvinyl-carboxyphosphonate phosphorylmutase YP_002822254.1 related to major facilitator superfamily YP_002822260.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities YP_002822263.1 similar to transmembrane protein YP_002822269.1 similar to ion transport 2 domain protein YP_002822290.1 Thioredoxin-dependent peroxide reductase; TPx-Eg YP_002822302.1 Heat shock protein 70 YP_002822305.1 cytochrome c554 YP_002822328.1 permease YP_002822329.1 permease YP_002822339.1 IclR family YP_002822346.1 periplasmic sensory protein associated with the TorRS two-component regulatory system YP_002822377.1 y4pL-like YP_002822380.1 ATP-hydrolyzing YP_002822391.1 Nitrogen assimilationcontrol protein YP_002822392.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_002822403.1 similar to lipase/esterase; lipQ protein YP_002822404.1 similar to alpha/beta hydrolase superfamily YP_002822406.1 similar to ABC transporter substrate-binding protein YP_002822409.1 N-carbamoylsarcosineamidohydrolase; CSHASE YP_002822410.1 similar to ammonia monooxygenase YP_002822420.1 polyprenylp-hydroxybenzoate decarboxylase YP_002822422.1 COdehydrogenase subunit L; CO-DH L YP_002822442.1 IMPase; Inositol-1-phosphatase; I-1-Pase YP_002822481.1 3-hydroxyacyl-CoA dehydrogenase type II; Type II HADH; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; Scully protein YP_002822485.1 Lactase YP_002822488.1 LBP YP_002822493.1 Melibiase YP_002822503.1 catalyzes the formation of malonyl-CoA from malonate and CoA YP_002822508.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate YP_002822509.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate YP_002822511.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine YP_002822525.1 Transaminase A; AspAT YP_002822534.1 ATP-binding cassette; transporter nucleotide-binding domai YP_002822542.1 acceptor YP_002822543.1 pyrroloquinoline quinonesynthesis protein A YP_002822544.1 possibly involved in transport of pyrroloquinoline quinone transport YP_002822545.1 Required in the synthesis of PPQ, but its exact function is unknown YP_002822546.1 Pyrroloquinoline quinonebiosynthesis protein D YP_002822547.1 Pyrroloquinoline quinonebiosynthesis protein E YP_002822554.1 3-hydroxybutyrate; depolymerase Lpq YP_002822563.1 S-methylmethionine-dependent; MHT YP_002822564.1 CGS; O-succinylhomoserine (Thiol)-lyase YP_002822608.1 catalyzes the hydrolysis of allophanate YP_002822626.1 HPr-like protei YP_002822629.1 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase YP_002822634.1 dioxygenase domain YP_002822635.1 XR; Dicarbonyl/L-xylulosereductase YP_002822638.1 2,5-DDOL dehydrogenase YP_002822650.1 3-ketoacyl-acyl carrier protein reductase YP_002822657.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_002822660.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm YP_002822679.1 catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine YP_002822700.1 equivalent to the dddD gene YP_002822705.1 FabF, beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP. YP_002822725.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; the rhizobia and the high GC gram-positive bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the S. meliloti protein in this cluster is associated with a groES gene and is required for regulation of the early genes involved in nodular formation YP_002822726.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_002822752.1 BDH; 3-hydroxybutyrate dehydrogenase; 3-HBDH YP_002822771.1 alpha/beta hydrolase superfamily YP_002822780.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress YP_002822781.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress YP_002822782.1 IAH; Indole-3-acetamidehydrolase YP_002822784.1 TRXR YP_002822792.1 Protein Cpn10 2; groES protein 2 YP_002822793.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; the rhizobia and the high GC gram-positive bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the S. meliloti protein in this cluster is associated with a groES gene and is required for regulation of the early genes involved in nodular formation YP_002822802.1 HHEDaldolase YP_002822803.1 OHEDhydratase YP_002822811.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_002822813.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis YP_002822840.1 HAD superfamily YP_002822846.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_002822849.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine YP_002822852.1 catalase-peroxidase YP_002822853.1 peroxidase/catalase YP_002822855.1 octopine oxidase subunit A YP_002822857.1 octopine oxidase subunit B YP_002822858.1 deaminating YP_002822861.1 OCD 2 YP_002822866.1 TDH; D-malate dehydrogenase [decarboxylating] YP_002822873.1 HAD superfamily YP_002822897.1 catalyzes the formation of 2-oxobutanoate from L-threonine; involved in ectoine utilization YP_002822898.1 cyclodeaminase YP_002822900.1 L-allo-TA; L-allo-threonineacetaldehyde-lyase YP_002822911.1 HK YP_002822912.1 aspartase YP_002822914.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine YP_002822917.1 catalyzes the oxidative deamination of D-amino acids YP_002822920.1 rieske iron-sulfur protein; RISP YP_002822934.1 similar to FAD-dependent monooxygenases YP_002822965.1 FBP aldolase YP_002822976.1 FdVI YP_002822985.1 catalyzes the conversion of citrate to isocitrate YP_002822986.1 catalyzes the formation of 2,5-dioxopentanoate from 5-dehydro-4-deoxy-D-glucarate YP_002823004.1 similar to transposase YP_002823018.1 N-terminus conserved YP_002823037.1 C-terminal truncated YP_002823041.1 DUF305 YP_002823061.1 CzcA family YP_002823063.1 C-terminus truncated YP_002823064.1 N-terminus truncated YP_002823072.1 C-terminus missing YP_002823076.1 FabF, beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP. YP_002823121.1 with partial similarity to protease YP_002823134.1 y4pL-like YP_002823149.1 rkp3_015 YP_002823150.1 rkp3_014 YP_002823151.1 rkp3_013 YP_002823152.1 rkp3_012 YP_002823162.1 rkp3_001a, N-terminal truncated capsule polysaccharide biosynthesis YP_002823163.1 rkp3_001b YP_002823176.1 similar to transmembrane protein YP_002823193.1 similar to plasmid stabilization protein YP_002823194.1 similar to plasmid stabilization protein YP_002823205.1 y4pL-like YP_002823206.1 similar to transposase YP_002823207.1 similar to transposase YP_002823222.1 similar to y4bF of pNGR234a YP_002823223.1 similar to Yle-like protein of A. tumefaciens YP_002823258.1 VirD4 family YP_002823262.1 similar to AttC YP_002823268.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; catalytic YP_002823269.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_002823272.1 or CreC YP_002823273.1 AONS; 8-amino-7-ketopelargonate synthase; 7-keto-8-amino-pelargonic acid synthetase; 7-KAP synthetase; L-alanine--pimelyl CoA ligase YP_002823278.1 similar to agaE protein, conversion of agropinic acid to mannopinic acid YP_002823287.1 similar to CpaE YP_002823294.1 similar to Flp/PilA component YP_002823304.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose YP_002823306.1 KAT2 YP_002823307.1 catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA; in mycobacteria LigC has weak intrinsic nick joining activities and is not essential for growth YP_002823325.1 SAM-MTas YP_002823350.1 E2 YP_002823356.1 similar to Lysine exporter family protein LYSE/YGGA YP_002823358.1 Rbt operon repressor YP_002823365.1 L-fuculose-1-phosphatealdolase YP_002823367.1 similar to mitochondrial precursor; 3-methylcrotonyl-CoA carboxylase 2; MCCase betasubunit; 3-methylcrotonyl-CoA:carbon dioxide ligase beta subunit YP_002823370.1 catalyzes the formation of acetoacetate and acetyl-CoA from 3-hydroxy-3-methylglutaryl-CoA YP_002823371.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_002823393.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP YP_002823394.1 in Rhizobium meliloti this protein is involved in the synthesis of nodulation factors that are active on the roots of alfalfa; catalyzes formation of activated sulfate intermediate; converts ATP and sulfate to diphosphate and adenylylsulfate and then ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; the activated intermediate is transferred to the nodulation factors by NodH; may interact with NodP and NodQ; similar to the CysD and CysN proteins from EScherichia coli involved in cysteine biosynthesis YP_002823398.1 undetermined role; similar to CarB protein but much smaller YP_002823401.1 WbpT YP_002823420.1 heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1; heparansulfate 3-O-sulfotransferase 3B1; h3-OST-3B YP_002823439.1 oligopeptide-binding protein YP_002823451.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_002823452.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_002823455.1 OmpR family YP_002823457.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) YP_002823464.1 catalyzes the formation of protocatechuate from 4-hydroxybenzoate YP_002823471.1 urate oxidase YP_002823478.1 Catalyzes the deamination of guanine YP_002823491.1 phosphodeoxyriboaldolase; deoxyriboaldolase; DERA; CGI-26 YP_002823500.1 dimethylargininase; dimethylarginine dimethylaminohydrolase YP_002823501.1 Enables the enzymatic reduction of mercuric ions to elemental mercury YP_002823523.1 similar to translation initiation inhibitors YP_002823528.1 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism YP_002823530.1 catalyzes the degradation of histidine to urocanate and ammmonia YP_002823531.1 catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway YP_002823537.1 similar to phosphonate ABC transporter substrate-binding protein YP_002823539.1 similar to mitochondrial precursor; GCD YP_002823545.1 dTDP-4-keto-6-deoxyglucose 3,5-epimerase; dTDP-L-rhamnose synthetase YP_002823547.1 CDP-glucosepyrophosphorylase YP_002823553.1 catalyzes the formation of 5-aminovulinate from (S)-4-amino-5-oxopentanoate YP_002823554.1 similar to transposase YP_002823565.1 molecular chaperone YP_002823566.1 3-hydroxyalkanoate synthetas YP_002823567.1 catalyzes the formation of acetyl phosphate from acetyl-CoA and phosphate; can also act with other short-chain acyl-CoAs YP_002823568.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_002823569.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_002823571.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate YP_002823573.1 LPS YP_002823577.1 class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis YP_002823597.1 PMM /PGM YP_002823627.1 HHEDaldolase YP_002823632.1 ATP binding protein YP_002823634.1 3-ketoacyl-acyl carrier protein reductase YP_002823637.1 similar to mitochondrial precursor; CHD; CDH YP_002823643.1 Transcriptional regulator that represses the manganese transporter MntH when manganese is present YP_002823658.1 sulfate-transporting ATPase 1 YP_002823661.1 GDH YP_002823667.1 catalyzes the reaction of formaldehyde with glutathione to form S-hydroxymethylglutathione YP_002823668.1 glutathione-dependent formaldehyde dehydrogenase; FDH; FALDH YP_002823675.1 BraE-2 YP_002823742.1 endo-1,4-beta-glucanase; cellulase YP_002823750.1 The second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione YP_002823755.1 membrane component of a sugar ABC transporter system YP_002823773.1 succinoglycanbiosynthesis protein ExsH YP_002823787.1 chloride peroxidase; CPO-L; chloroperoxidase L YP_002823792.1 chloride peroxidase; CPO-P; chloroperoxidase P YP_002823804.1 N-acetyl-beta-glucosaminidase; beta-N-acetylhexosaminidase YP_002823811.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_002823836.1 membrane-spanning dIIa subunit YP_002823837.1 NADH-binding dIlb subunit YP_002823843.1 LS-BP; L-BP YP_002823851.1 glutathione-dependent formaldehyde dehydrogenase; FDH; FALDH YP_002823866.1 NADP+ / Methenyltetrahydrofolat YP_002823879.1 y4pL-like YP_002823911.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine YP_002823919.1 Catalyzes the deamination of cytosine to uracil and ammonia YP_002823920.1 4-(phosphohydroxy)-L-threonine dehydrogenase 2 YP_002823942.1 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity YP_002823943.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_002823949.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane YP_002823961.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_002823970.1 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate YP_002823974.1 Pectinase; PGL YP_002824014.1 Methyl-accepting chemotaxis protein YP_002824016.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription YP_002824021.1 ExsB YP_002824026.1 Galactowaldenase YP_002824036.1 succinoglycanbiosynthesis protein ExoK YP_002824044.1 antioxidant protein 2; 1-cysperoxiredoxin; 1-cys PRX; acidic calcium-independent phospholipaseA2; aiPLA2; non-selenium glutathione peroxidase; nSGPx; Thiol-specific antioxidant protein YP_002824069.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_002824088.1 catalyzes the formation of L-proline from L-ornithine YP_002824089.1 similar to an amidinotransferase YP_002824101.1 Methyl-accepting chemotaxis protein YP_002824115.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell YP_002824116.1 cell division inhibitor MinD YP_002824117.1 blocks the formation of polar Z-ring septums YP_002824118.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_002824126.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate YP_002824136.1 16 kDa heat shock protein YP_002824137.1 E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_002824138.1 E2; Dihydrolipoamideacetyltransferase component of pyruvate dehydrogenase complex YP_002824151.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_002824152.1 OCD 2 YP_002824155.1 SGAT YP_002824171.1 acetoin dehydrogenase E2 component; Dihydrolipoamide acetyltransferase component of acetoin cleavingsystem YP_002824172.1 acetoin:DCPIP oxidoreductase-beta; AO:DCPIP OR; TPP-dependent acetoin dehydrogenase E1 subunit beta YP_002824173.1 acetoin:DCPIP oxidoreductase-alpha; AO:DCPIP OR YP_002824174.1 SEH; epoxide hydratase; cytosolic epoxide hydrolase; cEH YP_002824175.1 R-HPCDH; aliphatic epoxide carboxylation component III YP_002824180.1 similar to AcrR, transcriptional regulator, COG1309 YP_002824188.1 acetoin dehydrogenase E2 component; Dihydrolipoamide acetyltransferase component of acetoin cleavingsystem YP_002824189.1 acetoin:DCPIP oxidoreductase-beta; AO:DCPIP OR; TPP-dependent acetoin dehydrogenase E1 beta-subunit YP_002824190.1 acetoin:DCPIP oxidoreductase-alpha; AO:DCPIP OR YP_002824200.1 ALDDH YP_002824207.1 similar to a homoserine kinase type II protein kinase fold, COG2334 YP_002824212.1 HMSD YP_002824213.1 metapyrocatechase YP_002824215.1 catechol pathway YP_002824216.1 OHEDhydratase YP_002824217.1 HHEDaldolase YP_002824238.1 catalyzes the formation of glyoxylate from (S)-ureidoglycolate YP_002824242.1 catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate YP_002824245.1 involved in the transport of C4-dicarboxylates across the membrane YP_002824263.1 4 TMs inner membrane subunit YP_002824264.1 12 TMs inner membrane subunit YP_002824266.1 similar to NagD, sugar phosphatases of the HAD superfamily COG0647 YP_002824267.1 glutamate--ammonia ligase II; GSII YP_002824270.1 C-alpha-formyglycine-generating enzyme 2 YP_002824281.1 similar to RbsB, ABC-type sugar transport system, periplasmic component COG1879 YP_002824285.1 catalyzes the formation of 3-hydroxy-2-methylpropanoate from 3-hydroxy-2-methylpropanoyl-CoA YP_002824288.1 PpcB YP_002824291.1 MDM; functions in conversion of succinate to propionate YP_002824304.1 ABC superfamily, atp_bind/ C-P lyase component YP_002824307.1 in some organisms the DhaK and DhaL subunits are encoded by separate genes; in others they are fused; functions along with DhaM to phosphorylate dihydroxyacetone YP_002824312.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) YP_002824318.1 Catalyzes the cycloisomerization of cis,cis-muconate YP_002824341.1 catalyzes the thiolytic cleavage of beta-ketoadipyl-CoA to succinate and acetyl-CoA YP_002824347.1 catalyzes the hydrolysis of acylphosphate YP_002824348.1 member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription YP_002824354.1 GlnH YP_002824376.1 urea/amide YP_002824385.1 involved in the transport of C4-dicarboxylates across the membrane YP_002824389.1 GntR family YP_002824399.1 Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization YP_002824414.1 SMP-30; Regucalcin; RC YP_002824425.1 catalyzes the formation of 5-dehydro-D-gluconate from D-gluconate YP_002824449.1 amino acid YP_002824466.1 substrate-binding protein YP_002824467.1 permease YP_002824468.1 permease YP_002824469.1 ATP-binding protein YP_002824470.1 ATP-binding protein YP_002824487.1 similar to NodW YP_002824496.1 part of a set of proteins involved in the infection of eukaryotic cells; in plant pathogens involved in the hypersensitivity response YP_002824500.1 L-asparagine transport protein YP_002824516.1 catalyzes the release of the N-terminal amino acid from a tripeptide YP_002824523.1 cyclodeaminase YP_002824524.1 catalyzes the formation of 2-oxobutanoate from L-threonine; involved in ectoine utilization YP_002824544.1 TMAmethyltransferase 2 YP_002824552.1 glutathione-dependent formaldehyde dehydrogenase; FDH; FALDH YP_002824556.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_002824558.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_002824561.1 similar to activator of Hsp90 ATPase 1 family protein YP_002824564.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_002824565.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine YP_002824567.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_002824568.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons YP_002824569.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor YP_002824574.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen YP_002824579.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_002824584.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_002824587.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate YP_002824588.1 This protein performs the mismatch recognition step during the DNA repair process YP_002824589.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein YP_002824592.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002824598.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_002824603.1 Transfers the fatty acyl group on membrane lipoproteins YP_002824605.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_002824606.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_002824614.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_002824615.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth YP_002824616.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_002824618.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_002824625.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway YP_002824631.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_002824637.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_002824639.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_002824640.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates YP_002824641.1 in Escherichia coli transcription of this gene is enhanced by polyamines YP_002824654.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichia coli this protein self regulates transcription via a DNA-binding domain at the N-terminus but the protein from Pseudomonas does not have this domain YP_002824670.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_002824671.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_002824673.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_002824674.1 activates fatty acids by binding to coenzyme A YP_002824689.1 restriction endonuclease; the EcoKI enzyme recognizes 5'-AACN(6)GTGC-3'; subunit R is required for both nuclease and ATPase activities YP_002824702.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_002824706.1 DapATase; functions in arginine biosynthetic pathway; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine YP_002824707.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation YP_002824708.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers YP_002824709.1 protein associated with Co2+ and Mg2+ efflux YP_002824711.1 catalyzes the conversion of O-succinylhomoserine and sulfide to homocysteine; second step in methionine biosynthesis YP_002824712.1 Catalyzes the deamination of dCTP to form dUTP YP_002824721.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_002824730.1 partial similarity methyltransferase YP_002824734.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_002824739.1 homopentamer; channel that opens in response to pressure or hypoosmotic shock YP_002824740.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_002824754.1 part of the preprotein secretory system; forms a complex with protein YajC; SecDFyajC stimulates the proton motive force-driven protein translocation, seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_002824765.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate YP_002824774.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_002824776.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_002824779.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_002824780.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_002824792.1 similar to transglycosylase-associated protein YP_002824808.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins YP_002824810.1 catalyzes the conversion of glutamine residues to glutamate on methyl-accepting chemotaxis receptors YP_002824812.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod YP_002824816.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export YP_002824817.1 One of three proteins involved in switching the direction of the flagellar rotation YP_002824820.1 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_002824822.1 FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod; Bradyrhizobium have one thick flagellum and several thin flagella; the protein in this cluster is associated with the thin flagella YP_002824823.1 involved in type III protein export during flagellum assembly YP_002824825.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Bradyrhizobium have one thick flagellum and several thin flagella; the proteins in this cluster are associated with the thin flagella YP_002824826.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod YP_002824827.1 forms a junction between the M-ring and FlgB during flagella biosynthesis; Bradyrhizobium has one thick flagellum and several thin flagella; the protein in this cluster is associated with the thin flagella YP_002824828.1 makes up the distal portion of the flagellar basal body rod; Bradyrhizobium has one thick flagellum and several thin flagella; the Bradyrhizobium protein in this cluster is associated with the thick flagella YP_002824829.1 required for the assembly of the flagellar basal body P-ring; Bradyrhizobium japonicum has two types of flagella, a single thick flagella and a few thin flagella; the protein in this cluster is associated with the thin flagella YP_002824830.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum YP_002824832.1 part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod YP_002824834.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus YP_002824840.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_002824841.1 a periplasmic protein that interacts with and stabilizes MotB; in Rhizobium, interactions between MotB and MotC at the periplasmic surface of the motor control the energy flux or the energy coupling that drives flagellar rotation YP_002824845.1 the hook connects flagellar basal body to the flagellar filament YP_002824846.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook YP_002824847.1 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Bradyrhizobium has one thick flagellum and several thin flagella; the Bradyrhizobium protein in this cluster is associated with the thin flagella YP_002824848.1 acts as an activator or flagellin translation and may be required for filament secretion or assembly; Bradyrhizobium has one thick flagellum and several thin flagella; the protein in this cluster is associated with the thin flagella YP_002824849.1 post-transcriptional repressor of flagellum biosynthesis; promotes degradation of fljK mRNA: Bradyrhizobium has one thick flagellum and several thin flagella; the protein in this cluster is associated with the thin flagella YP_002824850.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; Bradyrhizobium has one thick flagellum and several thin flagella; the protein in this cluster is associated with the thin flagella YP_002824851.1 FliQ, with proteins FliP and FliR, forms the core of the central channel in the flagella export apparatus; Bradyrhizobium have one thick flagellum and several thin flagella; the protein in this cluster is associated with the thick flagellum YP_002824852.1 membrane protein involved in the flagellar export apparatus YP_002824853.1 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus YP_002824859.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_002824867.1 similar to glutathione-dependent formaldehyde-activating protein YP_002824868.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate YP_002824870.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_002824874.1 methyl-accepting chemotaxis protein YP_002824877.1 with partial similarity to isocitrate lyase YP_002824884.1 AcsA; in Sinorhizobium meliloti this enzyme is required for acetoacetate activation; similar to acetyl-CoA synthase YP_002824887.1 similar to phasin 2 YP_002824889.1 similar to DddC YP_002824895.1 rhizobial iron regulator; in Sinorhizobium meliloti mutations in this gene affect the expression of a number of iron-responsive operons YP_002824904.1 in Caulobacter crescentus, CC3477 is differentially expressed in minimal salts media with glucose as compared to complex media YP_002824920.1 activates RNA polymerase to cleave back-tracked RNA during elongational pausing YP_002824926.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_002824935.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_002824950.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_002824951.1 May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine YP_002824952.1 short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ YP_002824957.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth YP_002824958.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_002824963.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family; some organisms carry two different copies of this enzyme YP_002824974.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A YP_002824976.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate YP_002824978.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_002824982.1 catalyzes the formation of 3-methyl-2-oxobutanoate from 2,3,-dihydroxy-3-methylbutanoate YP_002824984.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism YP_002824996.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_002824997.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_002824998.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B' is part of the membrane proton channel. YP_002824999.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. YP_002825001.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_002825005.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_002825012.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_002825016.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_002825023.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_002825028.1 UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin YP_002825040.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_002825044.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_002825047.1 catalyzes the bidirectional exonucleolytic cleavage of DNA YP_002825063.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate YP_002825066.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_002825069.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_002825074.1 converts protoheme IX and farnesyl diphosphate to heme O YP_002825076.1 involved in the insertion of copper into subunit I of cytochrome C oxidase YP_002825082.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_002825083.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine YP_002825084.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids YP_002825092.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_002825101.1 Adenine-specificmethyltransferase SmeIP; M.SmeI; M.CcrMI YP_002825110.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_002825142.1 COdehydrogenase subunit S; CO-DH S YP_002825143.1 COdehydrogenase subunit M; CO-DH M YP_002825150.1 crotonase YP_002825151.1 3-ketoacyl-acyl carrier protein reductase YP_002825153.1 similar to DddB YP_002825156.1 ATP-AMP transphosphorylase YP_002825162.1 beta-IPM dehydrogenase; IMDH; 3-IPM-DH YP_002825163.1 ORFX YP_002825175.1 permease YP_002825176.1 phosphoribuloseisomerase YP_002825177.1 catalyzes the phosphorylation of ribulose to ribulose 5-phosphate YP_002825187.1 3-ketoacyl-acyl carrier protein reductase YP_002825192.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_002825204.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate YP_002825207.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_002825208.1 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity YP_002825209.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm YP_002825217.1 gentiobiase; cellobiase; beta-D-glucoside glucohydrolase YP_002825240.1 may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ YP_002825241.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP YP_002825242.1 PAPSreductase, thioredoxin dependent; PAdoPS reductase; 3-phosphoadenylylsulfate reductase; PAPS sulfotransferase YP_002825245.1 catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine YP_002825246.1 catalyzes the formation of betaine from betaine aldehyde YP_002825248.1 HTH-type; bet1; Repressor involved in choline regulation of the bet genes YP_002825267.1 catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate YP_002825279.1 cytochrome c556 YP_002825283.1 carbenicillinase YP_002825296.1 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved with K+ YP_002825297.1 subunit B of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in the case of S. meliloti it was proved to be involved specifically with K+ transport YP_002825298.1 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_002825299.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone; in S. meliloti it is known to be involved specifically with K+ transport YP_002825300.1 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport YP_002825301.1 subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport YP_002825302.1 subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport YP_002825326.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane YP_002825332.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme YP_002825349.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile YP_002825356.1 catalyzes the formation of histidinol phosphate and 2-oxoglutarate from glutamate and imidazole acetol-phosphate YP_002825364.1 DHDPS YP_002825365.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_002825371.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_002825373.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_002825374.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_002825381.1 UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH YP_002825382.1 UDP-glucuronic acidepimerase YP_002825387.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA YP_002825393.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate YP_002825394.1 catalyzes the formation of oxaloacetate from L-aspartate YP_002825395.1 Quinolinate phosphoribosyltransferase[decarboxylating]; QAPRTase YP_002825400.1 glycine cleavage YP_002825406.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_002825416.1 catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine YP_002825417.1 phosphatidylserine synthase YP_002825419.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_002825421.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_002825426.1 unwinds double stranded DNA YP_002825427.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_002825429.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_002825430.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_002825434.1 catalyzes the formation of 3-hydroxyacyl-ACP from 3-keto-acyl-ACP; in the rhizobia this protein interacts with NodF to allow for the synthesis of highly polyunsaturated fatty acids necessary for nodulation YP_002825435.1 carries the fatty acid chain in fatty acid biosynthesis YP_002825436.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_002825440.1 Essential for recycling GMP and indirectly, cGMP YP_002825441.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_002825442.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) YP_002825447.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_002825448.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB YP_002825456.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_002825463.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_002825472.1 lysine--tRNA ligase 2; LysRS 2 YP_002825474.1 similar to y4rI of pNGR234a YP_002825475.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate YP_002825476.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_002825479.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate YP_002825483.1 ATP pyrophosphate-lyase 2; adenylylcyclase 2 YP_002825487.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_002825488.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; the rhizobia have multiple copies of the groEL gene which are active under different environmental conditions; the S. meliloti protein in this cluster is not associated with a groES gene YP_002825491.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_002825494.1 R-transferase; Arginyltransferase YP_002825496.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_002825500.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_002825503.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_002825507.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_002825508.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_002825510.1 pyrophosphate-energized proton pump; pyrophosphate-energized inorganic pyrophosphatase; H+-PPase; can cleave pyrophosphate to two phosphates; can generate a proton motive force and drive pyrophosphate synthesis when PMF is sufficient YP_002825514.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_002825515.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_002825516.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_002825524.1 polyprenylp-hydroxybenzoate decarboxylase YP_002825532.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_002825538.1 Cu-NIR YP_002825541.1 blue copper protein YP_002825545.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC YP_002825561.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis YP_002825562.1 catalyzes the formation of putrescine from agmatine YP_002825564.1 forms a direct contact with the tRNA during translation YP_002825565.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_002825567.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_002825570.1 catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol YP_002825576.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_002825577.1 binds and unfolds substrates as part of the ClpXP protease YP_002825587.1 Catalyzes the transfer of electrons from NADH to quinone YP_002825588.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen YP_002825589.1 Catalyzes the transfer of electrons from NADH to quinone YP_002825590.1 Catalyzes the transfer of electrons from NADH to quinone YP_002825592.1 Catalyzes the transfer of electrons from NADH to quinone YP_002825593.1 part of NADH-ubiquinone oxidoreductase complex I; shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase YP_002825595.1 Catalyzes the transfer of electrons from NADH to quinone YP_002825596.1 Catalyzes the transfer of electrons from NADH to quinone YP_002825597.1 Catalyzes the transfer of electrons from NADH to quinone YP_002825598.1 Catalyzes the transfer of electrons from NADH to quinone YP_002825599.1 Catalyzes the transfer of electrons from NADH to quinone YP_002825600.1 Catalyzes the transfer of electrons from NADH to ubiquinone YP_002825601.1 Catalyzes the transfer of electrons from NADH to quinone YP_002825602.1 Catalyzes the transfer of electrons from NADH to quinone YP_002825605.1 glyoxalase I YP_002825607.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_002825612.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase YP_002825614.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_002825618.1 CheY-like protein YP_002825619.1 involved in swarmer-to-stalked cell differentiation in Caulobacter crescentus; catalyzes the condensation of two GTP molecules to form the secondary messenger cyclic di-GMP (c-di-GMP); upon phosphorylation of domain D1 the protein dimerizes; presumably this allows the two GTP-bound GGDEF (diguanylate cyclase) domains to catalyze the condensation reaction; allosterically inhibited by c-di-GMP YP_002825625.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_002825627.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX YP_002825628.1 Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides YP_002825629.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_002825633.1 catalyzes the opening and hydrolysis of the beta-lactam ring of beta-lactam antibiotics such as penicillins and cephalosporins YP_002825634.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain YP_002825635.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_002825639.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_002825643.1 Provides the input to the respiratory chain from the NAD-linked dehydrogenases of the citric acid cycle. The complex couples the oxidation of NADH and the reduction of ubiquinone, to the generation of a proton gradient which is then used for ATP synthesis YP_002825645.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys YP_002825646.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_002825647.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_002825648.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis YP_002825655.1 catalyzes the release of newly synthesized polypeptide chains at the stop codons UAA and UGA YP_002825657.1 catalyzes the phosphorylation of NAD to NADP YP_002825672.1 terminase large subunit YP_002825699.1 adenine-specificmethyltransferase EcaI; M.EcaI YP_002825706.1 ACPphosphodiesterase YP_002825709.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_002825711.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_002825712.1 Modulates Rho-dependent transcription termination YP_002825713.1 binds directly to 23S ribosomal RNA YP_002825714.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_002825716.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_002825717.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_002825718.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_002825719.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_002825721.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_002825722.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_002825723.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_002825724.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_002825725.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_002825726.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_002825727.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_002825728.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_002825729.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_002825730.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_002825731.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_002825732.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_002825733.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_002825734.1 one of the stabilizing components for the large ribosomal subunit YP_002825735.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_002825736.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_002825737.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_002825738.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_002825739.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_002825740.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_002825741.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_002825742.1 binds 5S rRNA along with protein L5 and L25 YP_002825743.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_002825744.1 late assembly protein YP_002825745.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_002825746.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_002825747.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_002825748.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_002825749.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_002825750.1 is a component of the macrolide binding site in the peptidyl transferase center YP_002825751.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme YP_002825752.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ YP_002825763.1 glutathione-dependent formaldehyde dehydrogenase; FDH; FALDH YP_002825767.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein YP_002825772.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_002825790.1 PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers YP_002825791.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_002825795.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_002825799.1 similar to protein MTH152 YP_002825805.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_002825810.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_002825811.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_002825813.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis YP_002825814.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_002825817.1 catalyzes the oxidative decarboxylation of pyruvate with concomitant acetylation of a lipoic acid-containing dihydrolipoamide acetyltransferase within the complex. The E1 component of the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase(E2) and lipoamide dehydrogenase YP_002825819.1 E2; dihydrolipoamideacetyltransferase component of pyruvate dehydrogenase complex YP_002825822.1 E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_002825824.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_002825828.1 bifunctional enzyme involved in formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate and 2-C-methyl-D-erythritol 2,4-cyclodiphosphate and CMP from 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; binds divalent cations YP_002825831.1 sensor glnL; nitrogen regulator I, NRI YP_002825834.1 catalyzes the transamination of D-amino acids and their alpha-keto acids YP_002825835.1 Stimulates the elongation of poly(A) tails YP_002825837.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era YP_002825851.1 catalyzes the formation of L-homocysteine from cystathionine YP_002825858.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA YP_002825867.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_002825868.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_002825869.1 Catalyzes the phosphorylation of UMP to UDP YP_002825870.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_002825871.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate YP_002825875.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis YP_002825876.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_002825877.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis YP_002825879.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM YP_002825880.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH YP_002825890.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_002825897.1 dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate YP_002825898.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_002825904.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes YP_002825905.1 mediates the export of protein precursors bearing twin-arginine signal peptides YP_002825907.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002825908.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate YP_002825909.1 catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins YP_002825913.1 YajC YP_002825914.1 part of the preprotein secretory system; forms a complex with protein YajC; SecDFyajC stimulates the proton motive force-driven protein translocation, seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_002825924.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_002825926.1 catalyzes the conversion of NADPH to NADH YP_002825928.1 AacA4 YP_002825929.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase YP_002825930.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_002825932.1 poly(3-hydroxybutyrate) polymerase; PHB polymerase; PHB synthase; poly(3-hydroxyalkanoate) polymerase; PHA polymerase; PHA synthase; polyhydroxyalkanoic acid synthase YP_002825934.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine YP_002825946.1 PCMT YP_002825957.1 Catalyzes the first step in the glyoxalate cycle, which converts lipids to carbohydrates YP_002825968.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine YP_002825978.1 permease protein YP_002825979.1 substrate-binding protein YP_002825983.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis YP_002825984.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water YP_002825985.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate YP_002825989.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_002825990.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_002825993.1 catalyzes branch migration in Holliday junction intermediates YP_002825999.1 glutamine synthetase I; glutamate--ammonia ligase I; GSI YP_002826002.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively YP_002826004.1 stationary phase protein that binds TrpR repressor YP_002826005.1 similar to y4rI of pNGR234a YP_002826012.1 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic YP_002826014.1 periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate YP_002826022.1 CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis YP_002826025.1 SMR superfamily YP_002826029.1 Represses a number of genes involved in the response to DNA damage YP_002826038.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_002826057.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_002826058.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling YP_002826062.1 with SufCD activates cysteine desulfurase SufS YP_002826068.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine YP_002826069.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor YP_002826076.1 Catalyzes the rate-limiting step in dNTP synthesis YP_002826078.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_002826079.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA YP_002826081.1 negatively supercoils closed circular double-stranded DNA YP_002826094.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_002826100.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_002826103.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_002826104.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_002826111.1 2,5-DDOL dehydrogenase YP_002826115.1 similar to y4bF of pNGR234a YP_002826123.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_002826125.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_002826126.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_002826137.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_002826138.1 With PurL and PurQ catalyzes the conversion of formylglycinamide ribonucleotide, ATP, and glutamine to formylglycinamidine ribonucleotide, ADP, and glutamate in the fourth step of the purine biosynthetic pathway YP_002826139.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_002826144.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_002826152.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs YP_002826153.1 catalyzes the formation of glutamate from glutamine YP_002826154.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_002826159.1 converts L-glutamate to D-glutamate, a component of peptidoglycan YP_002826161.1 Converts isocitrate to alpha ketoglutarate YP_002826164.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002826165.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_002826187.1 GST B1-1 YP_002826197.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis YP_002826206.1 NAD-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; does not decarboxylate oxaloacetate YP_002826212.1 NH(3)-dependent; catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_002826217.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense YP_002826219.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway YP_002826220.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate YP_002826222.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_002826228.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z YP_002826229.1 methyl-accepting chemotaxis protein YP_002826231.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis YP_002826233.1 cysteine-richprotein D; PBP 4; penicillin-binding protein 4 YP_002826246.1 similar to exoI YP_002826249.1 DAGK; diglyceride kinase; DGK YP_002826251.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole YP_002826267.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_002826284.1 1,4-beta-D-xylan xylohydrolase; xylan 1,4-beta-xylosidase YP_002826288.1 identical to y4hQ of pNGR234a YP_002826289.1 identical to y4hP of pNGR234a YP_002826290.1 identical to y4hO of pNGR234a YP_002826291.1 identical to y4hN of pNGR234a YP_002826306.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate YP_002826308.1 E1-E2 type cation ATPase FixI YP_002826315.1 CcoO; FixO YP_002826316.1 CcoN; FixN YP_002826320.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA YP_002826322.1 FabF, beta-Ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP. YP_002826323.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_002826325.1 Involved in the biosynthetic pathways of fatty acids, phospholipids, lipopolysaccharides, and oligosaccharides YP_002826329.1 CobD; CbiD in Salmonella; converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group YP_002826331.1 responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid YP_002826335.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide YP_002826336.1 with CobST catalyzes the formation of cobyrinic acid a,c-diamide from hydrogenobyrinic acid a,c-diamide in an ATP-dependent manner; involved in porphyrin and chlorophyll metabolism; vitamin B12 metabolism YP_002826338.1 catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP YP_002826340.1 ATP pyrophosphate-lyase 1; adenylylcyclase 1 YP_002826341.1 catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation YP_002826346.1 catalyzes the formation of methionine from L-homocysteine and S-adenosyl-L-methionine YP_002826363.1 catalyzes the transfer of the N5-methyl group from (6S)-methyl tetrahydrofolate to the cobalt center of a corrinoid iron-sulfur protein YP_002826402.1 similar to glycosyl transferase YP_002826421.1 terminase large subunit YP_002826433.1 similar to chromosomal replication initiator protein DnaA YP_002826446.1 catalyzes the reaction of formaldehyde with glutathione to form S-hydroxymethylglutathione YP_002826464.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_002826467.1 PGPase; PGP YP_002826492.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_002826509.1 involved in the de novo synthesis of pyridoxine (Vitamin B6) YP_002826525.1 anti-sigma factor YP_002826532.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit YP_002826537.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_002826548.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichia coli this protein self regulates transcription via a DNA-binding domain at the N-terminus but the protein from Pseudomonas does not have this domain YP_002826563.1 glutathione-dependent formaldehyde dehydrogenase; FDH; FALDH YP_002826565.1 catalyzes the reaction of formaldehyde with glutathione to form S-hydroxymethylglutathione YP_002826584.1 braE-2 YP_002826603.1 SCO1/SenC/PrrC-like YP_002826604.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype YP_002826610.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_002826611.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_002826613.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB YP_002826616.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis YP_002826617.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_002826620.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_002826621.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_002826622.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_002826623.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_002826625.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_002826626.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_002826628.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_002826632.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_002826637.1 catalyzes the formation of fructose 1,6-bisphosphate from fructose 6-phosphate and diphosphate YP_002826648.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_002826668.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_002826672.1 Converts (S)-3-hydroxyacyl-CoA to 3-oxyacyl-CoA; may also act as a thioesterase YP_002826675.1 catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA YP_002826687.1 catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation YP_002826701.1 catalyzes the formation of methanethiol and 2-ocobutanoate from L-methionine YP_002826724.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen YP_002826728.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone; in S. meliloti it is known to be involved specifically with K+ transport YP_002826730.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone YP_002826746.1 MFS superfamily YP_002826757.1 y4pL-like YP_002826772.1 similar to bp26 antigen of Brucella YP_002826779.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria YP_002826781.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism YP_002826782.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine YP_002826784.1 synthesizes RNA primers at the replication forks YP_002826786.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_002826788.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_002826801.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate YP_002826804.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_002826809.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_002826831.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_002826834.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_002826836.1 similar to hemolysin-type calcium-binding repeat YP_002826838.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA YP_002826839.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_002826859.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_002826861.1 NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis YP_002826863.1 trpE(G); catalyzes the formation of anthranilate from chorismate and glutamine; contains both component I and II YP_002826868.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate YP_002826875.1 catalyzes the formation of thymidine 5'-phosphate from thymidine YP_002826881.1 catalyze the conversion of beta amino acids to the corresponding beta keto acid with pyruvate as the amine acceptor YP_002826885.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_002826889.1 in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope YP_002826891.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mnin Bacillus subtilis the protein in this cluster is considered non-essential YP_002826904.1 Catalyzes the deamination of guanine YP_002826907.1 catalyzes the formation of glyoxylate from (S)-ureidoglycolate YP_002826921.1 catalyzes the formation of 3-methyl-2-oxobutanoate from 2,3,-dihydroxy-3-methylbutanoate YP_002826958.1 quarternaryammonium determinant E YP_002826970.1 with HmuTU is involved in the transport of hemin YP_002826974.1 Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription YP_002826976.1 in Caulobacter crescentus, CC3477 is differentially expressed in minimal salts media with glucose as compared to complex media YP_002826980.1 Converts D-sorbitol to L-sorbose YP_002826986.1 function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain YP_002826987.1 catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines YP_002826993.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide YP_002826994.1 catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position YP_002827005.1 involved in the assembly of the urease metallocenter; possible nickel donor YP_002827007.1 thioredoxin reductase YP_002827010.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits YP_002827013.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) is involved with urease activity, optimum growth, resistance to low-pH killing in-vitro and persistence in-vivo, while the other operon does not seem to be active YP_002827015.1 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter YP_002827020.1 FabF, beta-Ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_002827021.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate YP_002827022.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium YP_002827023.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine YP_002827079.1 Zn containing; adh-3 YP_002827090.1 CcoO; FixO YP_002827091.1 CcoN; FixN YP_002827119.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_002827123.1 catalyzes the ring cleavage reaction in phenylacetate degradation and the formation of 3-hydroxyacyl-CoA from crotonyl-CoA YP_002827128.1 with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA; involved in phenylacetate degradation YP_002827129.1 with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA YP_002827132.1 SGAT YP_002827134.1 catalyzes the formation of malyl-CoA from malate and CoA YP_002827135.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle YP_002827149.1 catalyzes the formation of 3-methyl-2-oxobutanoate from 2,3,-dihydroxy-3-methylbutanoate YP_002827151.1 catalyzes the formation of 3-methyl-2-oxobutanoate from 2,3,-dihydroxy-3-methylbutanoate YP_002827160.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_002827162.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation. YP_002827164.1 Involved in ubiquinone biosynthesis YP_002827168.1 COMF YP_002827169.1 similar to BioC YP_002827173.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate YP_002827175.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_002827186.1 this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu YP_002827192.1 beta-ETF; electrontransfer flavoprotein small subunit; ETFSS YP_002827194.1 converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA YP_002827195.1 cytochrome c biogenesisprotein TlpA YP_002827196.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_002827209.1 dual function enzyme catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate and the formation of tyrosine from arogenate YP_002827210.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_002827216.1 required for 70S ribosome assembly YP_002827224.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_002827225.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_002827227.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_002827228.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein YP_002827241.1 catalyzes the deimination of N-formimino-L-glutamate to ammonia and N-formyl-L-glutamate YP_002827255.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_002827267.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters YP_002827269.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_002827271.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_002827272.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate YP_002827275.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_002827280.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA YP_002827291.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_002827292.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_002827293.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_002827305.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_002827308.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_002827316.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_002827319.1 proposed role in polysaccahride synthesis YP_002827324.1 catalyzes the formation of thiamine monophosphate from 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate and 4-methyl-5-(2-phosphono-oxyethyl)-thiazole YP_002827330.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_002827331.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif YP_002827334.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_002827342.1 catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine YP_002827349.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_002827351.1 catalyzes the degradation of arginine to citruline and ammonia YP_002827367.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate YP_002827379.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_002827392.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain YP_002827393.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate YP_002827394.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose YP_002827395.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate YP_002827403.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_002827421.1 LYSE/YGGA YP_002827430.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate YP_002827444.1 catalyzes the interconversion of D-xylose to D-xylulose YP_002827454.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_002827455.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_002827462.1 catalyzes the ATP-dependent formation of a phosphodiester at the site of a single strand break in duplex DNA YP_002827464.1 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved with K+ YP_002827465.1 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_002827466.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone YP_002827468.1 subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport YP_002827473.1 CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production, one aerobic (ex. P. denitrificans), the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6 YP_002827474.1 catalyzes the formation of precorrin-4 from precorrin-3B and S-adenosyl-L-methionine YP_002827475.1 catalyzes the formation of precorrin-3 from precorrin-2 YP_002827476.1 catalyzes the interconversion of precorrin-8X and hydrogenobyrinate YP_002827478.1 catalyzes the formation of precorrin 6x from precorrin 5 YP_002827479.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_002827481.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE YP_002827488.1 E3 component of the branched-chain alpha-keto acid dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_002827490.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine YP_002827494.1 An oxygenase that acts to open the ring of homogentisate formingmaleylacetoacetate as part of the catabolism of L-tyrosine and L-phenylalanine YP_002827503.1 HlyD family YP_002827504.1 similar to cellulose biosynthesis protein YP_002827512.1 BADH YP_002827521.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate YP_002827539.1 ROK family protein yajF YP_002827542.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity YP_002827556.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_002827558.1 catalyzes the formation of 5-aminolevulinate from succinyl-CoA and glycine YP_002827575.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth YP_002827578.1 catalyzes the oxidation of formate to carbon dioxide and hydrogen using NAD or NADP as the acceptor YP_002827582.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane YP_002827589.1 ferric uptake regulator YP_002827595.1 similar to y4rI of pNGR234a YP_002827598.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_002827599.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_002827600.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_002827601.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_002827602.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_002827604.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity YP_002827605.1 similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity YP_002827607.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_002827610.1 Catalyzes the oxidation of dihydrolipoamide to lipoamide YP_002827613.1 LYSE/YGGA YP_002827614.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA YP_002827615.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_002827616.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle YP_002827618.1 Catalyzes the reversible oxidation of malate to oxaloacetate YP_002827622.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase YP_002827623.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_002827628.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_002827637.1 Amt family YP_002827644.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_002827648.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis YP_002827657.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_002827658.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_002827659.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_002827660.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria YP_002827662.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_002827666.1 hydrolyzes diadenosine polyphosphate YP_002827683.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia YP_002827688.1 catalyzes the hydrolysis of pyrophosphate to phosphate YP_002827692.1 Catalyzes the transfer of the ammonia group from glutamine to a new carbon-nitrogen group YP_002827696.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane YP_002827697.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_002827698.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_002827699.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_002827700.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity YP_002827703.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_002827707.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_002827708.1 Essential for efficient processing of 16S rRNA YP_002827709.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_002827710.1 catalyzes the interconversion of chorismate to prephenate YP_002827714.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_002827717.1 Involved in cell division; probably involved in intracellular septation YP_002827723.1 ATP-binding protein; required for proper cytochrome c maturation YP_002827724.1 Catalyzes the conversion of citrate to isocitrate YP_002827734.1 4-alpha-hydroxytetrahydrobiopterin dehydratase activity; catalyzes the formation of (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7, 8-dihydro-6H-pterin from (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7, 8-tetrahydro-4a-hydroxypterin; functions in recycling tetrahydrobiopterin (BH4) in phenylalanine hydroxylase reaction YP_002827738.1 LYSE/YGGA YP_002827745.1 part of the thiamine and TPP transport system tbpA-thiPQ YP_002827746.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine YP_002827750.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma-32 is responsible for the expression of heat shock promoters; there are paralogs in Rhizobium and Sinorhizobium; the proteins in this cluster act as secondary heat shock sigma factors; the Rhizobium sigma-32 factor may also be involved in exopolysaccharide production YP_002827756.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis YP_002827759.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan YP_002827761.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_002827762.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_002827769.1 biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate YP_002827771.1 responsible for transport of beta-1,2-glucans from the cytoplasm to periplasm; inner membrane ABC transporter permease component; Cgt; ChvA; NdvA YP_002827781.1 catalyzes the formation of pyruvate and beta-alanine from L-alanine and 3-oxopropanoate YP_002827795.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_002827801.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_002827805.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_002827808.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal YP_002827811.1 involved in de novo purine biosynthesis YP_002827814.1 putative metalloprotease YP_002827816.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA YP_002827818.1 N-acetyldiaminobutyrate dehydratase; catalyzes the formation of the osmoprotectant ecotoine from gamma-N-acetyl-alpha,gamma-diaminobutyric acid YP_002827822.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_002827824.1 required for the assembly and function of the DNAX complex which are required for the assembly of the beta subunit onto primed DNA YP_002827827.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_002827828.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_002827829.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_002827830.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_002827832.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_002827834.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_002827835.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_002827836.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_002827837.1 3'-5' exonuclease of DNA polymerase III YP_002827838.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA YP_002827844.1 negatively supercoils closed circular double-stranded DNA YP_002827860.1 catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis YP_002827861.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_002827862.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_002827863.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits YP_002827871.1 catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine YP_002827877.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP YP_002827881.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis YP_002827882.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis YP_002827883.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_002827884.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_002827885.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_002827887.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis YP_002827888.1 heat shock protein involved in degradation of misfolded proteins YP_002827890.1 heat shock protein involved in degradation of misfolded proteins YP_002827894.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA YP_002827903.1 catalyzes the formation of L-proline from L-ornithine YP_002827915.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_002827930.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis YP_002827931.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation YP_002827932.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate YP_002827934.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_002827936.1 catalyzes the formation of inosine from adenosine YP_002827937.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose YP_002827940.1 PilQ YP_002827960.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm YP_002827961.1 catalyzes the formation of methylglyoxal from glycerone phosphate YP_002827962.1 catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate YP_002827965.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_002827966.1 catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate YP_002827976.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase YP_002827977.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_002827983.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_002827984.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_002827992.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_002828007.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway YP_002828015.1 putative role in sulfur assimilation YP_002828018.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress YP_002828025.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_002828027.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS YP_002828028.1 catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis YP_002828034.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA YP_002828036.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_002828041.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_002828042.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_002828044.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_002828045.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_002828046.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_002828048.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_002828051.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_002828052.1 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_002828053.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP YP_002828058.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_002828060.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_002828061.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_002828080.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_002828089.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_002828094.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits YP_002828100.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_002828101.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_002828102.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_002828110.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_002828111.1 quinone YP_002828121.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_002828126.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_002828127.1 Enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine YP_002828140.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_002828144.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase YP_002828149.1 binds the polymerase to DNA and acts as a sliding clamp YP_002828157.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione YP_002828160.1 LYSE/YGGA YP_002828165.1 catalyzes the formation of dUMP from dUTP YP_002828181.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine YP_002828187.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone YP_002828188.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_002828189.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_002828190.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase