-- dump date   	20120504_160304
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
101510000001	Fic family protein [Function unknown]; Region: COG3177
101510000002	classical (c) SDRs; Region: SDR_c; cd05233
101510000003	NAD(P) binding site [chemical binding]; other site
101510000004	active site
101510000005	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
101510000006	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
101510000007	Transposase, Mutator family; Region: Transposase_mut; pfam00872
101510000008	Transposase, Mutator family; Region: Transposase_mut; pfam00872
101510000009	MULE transposase domain; Region: MULE; pfam10551
101510000010	Integrase core domain; Region: rve; cl01316
101510000011	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
101510000012	cell division control protein 6; Reviewed; Region: cdc6; PRK00411
101510000013	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
101510000014	catalytic residues [active]
101510000015	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
101510000016	Transposase; Region: DDE_Tnp_ISL3; pfam01610
101510000017	Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043
101510000018	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
101510000019	FAD binding pocket [chemical binding]; other site
101510000020	conserved FAD binding motif [chemical binding]; other site
101510000021	phosphate binding motif [ion binding]; other site
101510000022	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
101510000023	active site
101510000024	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
101510000025	DNA binding site [nucleotide binding]
101510000026	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
101510000027	DNA binding site [nucleotide binding]
101510000028	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
101510000029	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
101510000030	Ligand Binding Site [chemical binding]; other site
101510000031	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
101510000032	Ligand Binding Site [chemical binding]; other site
101510000033	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
101510000034	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
101510000035	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
101510000036	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
101510000037	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
101510000038	Ligand Binding Site [chemical binding]; other site
101510000039	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
101510000040	Ligand Binding Site [chemical binding]; other site
101510000041	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
101510000042	FMN binding site [chemical binding]; other site
101510000043	dimer interface [polypeptide binding]; other site
101510000044	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
101510000045	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
101510000046	Ligand Binding Site [chemical binding]; other site
101510000047	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
101510000048	Ligand Binding Site [chemical binding]; other site
101510000049	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
101510000050	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
101510000051	Walker A/P-loop; other site
101510000052	ATP binding site [chemical binding]; other site
101510000053	Q-loop/lid; other site
101510000054	ABC transporter signature motif; other site
101510000055	Walker B; other site
101510000056	D-loop; other site
101510000057	H-loop/switch region; other site
101510000058	hypothetical protein; Provisional; Region: PRK07877
101510000059	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
101510000060	dimer interface [polypeptide binding]; other site
101510000061	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
101510000062	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518
101510000063	nickel binding site [ion binding]; other site
101510000064	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
101510000065	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419
101510000066	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
101510000067	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
101510000068	FAD binding pocket [chemical binding]; other site
101510000069	FAD binding motif [chemical binding]; other site
101510000070	phosphate binding motif [ion binding]; other site
101510000071	beta-alpha-beta structure motif; other site
101510000072	NAD binding pocket [chemical binding]; other site
101510000073	Iron coordination center [ion binding]; other site
101510000074	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
101510000075	anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055
101510000076	Domain of unknown function (DUF1876); Region: DUF1876; pfam08962
101510000077	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
101510000078	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
101510000079	Glutaminase; Region: Glutaminase; cl00907
101510000080	Predicted membrane protein (DUF2078); Region: DUF2078; cl01373
101510000081	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
101510000082	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
101510000083	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
101510000084	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
101510000085	Ligand Binding Site [chemical binding]; other site
101510000086	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
101510000087	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
101510000088	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
101510000089	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
101510000090	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
101510000091	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
101510000092	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
101510000093	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
101510000094	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510000095	active site
101510000096	phosphorylation site [posttranslational modification]
101510000097	intermolecular recognition site; other site
101510000098	dimerization interface [polypeptide binding]; other site
101510000099	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510000100	DNA binding residues [nucleotide binding]
101510000101	dimerization interface [polypeptide binding]; other site
101510000102	GAF domain; Region: GAF; cl00853
101510000103	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
101510000104	GAF domain; Region: GAF; cl00853
101510000105	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
101510000106	Histidine kinase; Region: HisKA_3; pfam07730
101510000107	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510000108	ATP binding site [chemical binding]; other site
101510000109	Mg2+ binding site [ion binding]; other site
101510000110	G-X-G motif; other site
101510000111	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
101510000112	Ligand Binding Site [chemical binding]; other site
101510000113	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
101510000114	Ligand Binding Site [chemical binding]; other site
101510000115	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
101510000116	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
101510000117	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
101510000118	Coenzyme A binding pocket [chemical binding]; other site
101510000119	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691
101510000120	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510000121	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
101510000122	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
101510000123	putative substrate binding site [chemical binding]; other site
101510000124	putative ATP binding site [chemical binding]; other site
101510000125	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
101510000126	active site
101510000127	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
101510000128	active site
101510000129	FOG: CBS domain [General function prediction only]; Region: COG0517
101510000130	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
101510000131	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
101510000132	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
101510000133	Ligand Binding Site [chemical binding]; other site
101510000134	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510000135	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
101510000136	Domain of unknown function (DUF4389); Region: DUF4389; pfam14333
101510000137	Domain of unknown function (DUF4389); Region: DUF4389; pfam14333
101510000138	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510000139	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
101510000140	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510000141	active site
101510000142	phosphorylation site [posttranslational modification]
101510000143	intermolecular recognition site; other site
101510000144	dimerization interface [polypeptide binding]; other site
101510000145	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
101510000146	DNA binding site [nucleotide binding]
101510000147	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
101510000148	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510000149	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
101510000150	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510000151	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
101510000152	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000153	peptide synthase; Validated; Region: PRK05691
101510000154	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510000155	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
101510000156	dimerization interface [polypeptide binding]; other site
101510000157	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
101510000158	dimer interface [polypeptide binding]; other site
101510000159	phosphorylation site [posttranslational modification]
101510000160	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510000161	ATP binding site [chemical binding]; other site
101510000162	Mg2+ binding site [ion binding]; other site
101510000163	G-X-G motif; other site
101510000164	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
101510000165	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510000166	active site
101510000167	phosphorylation site [posttranslational modification]
101510000168	intermolecular recognition site; other site
101510000169	dimerization interface [polypeptide binding]; other site
101510000170	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
101510000171	DNA binding site [nucleotide binding]
101510000172	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
101510000173	active site
101510000174	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
101510000175	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614
101510000176	putative transposase OrfB; Reviewed; Region: PHA02517
101510000177	Integrase core domain; Region: rve; cl01316
101510000178	Helix-turn-helix domains; Region: HTH; cl00088
101510000179	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614
101510000180	NAD(P) binding site [chemical binding]; other site
101510000181	Domain of unknown function (DUF385); Region: DUF385; cl04387
101510000182	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
101510000183	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510000184	enoyl-CoA hydratase; Provisional; Region: PRK07511
101510000185	substrate binding site [chemical binding]; other site
101510000186	oxyanion hole (OAH) forming residues; other site
101510000187	trimer interface [polypeptide binding]; other site
101510000188	Domain of unknown function DUF20; Region: UPF0118; cl00465
101510000189	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
101510000190	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
101510000191	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
101510000192	anti sigma factor interaction site; other site
101510000193	regulatory phosphorylation site [posttranslational modification]; other site
101510000194	Glycosyltransferase family 20; Region: Glyco_transf_20; pfam00982
101510000195	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
101510000196	active site
101510000197	homotetramer interface [polypeptide binding]; other site
101510000198	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
101510000199	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
101510000200	putative ADP-binding pocket [chemical binding]; other site
101510000201	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
101510000202	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
101510000203	GAF domain; Region: GAF; cl00853
101510000204	ANTAR domain; Region: ANTAR; cl04297
101510000205	Predicted membrane protein [Function unknown]; Region: COG4129
101510000206	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122
101510000207	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
101510000208	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
101510000209	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
101510000210	DNA binding residues [nucleotide binding]
101510000211	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
101510000212	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
101510000213	DNA-binding site [nucleotide binding]; DNA binding site
101510000214	RNA-binding motif; other site
101510000215	Ferritin-like domain; Region: Ferritin; pfam00210
101510000216	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
101510000217	dimerization interface [polypeptide binding]; other site
101510000218	DPS ferroxidase diiron center [ion binding]; other site
101510000219	ion pore; other site
101510000220	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
101510000221	Protein of unknown function (DUF1469); Region: DUF1469; cl12095
101510000222	DinB superfamily; Region: DinB_2; cl00986
101510000223	Cutinase; Region: Cutinase; cl15711
101510000224	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
101510000225	ANTAR domain; Region: ANTAR; cl04297
101510000226	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
101510000227	anti sigma factor interaction site; other site
101510000228	regulatory phosphorylation site [posttranslational modification]; other site
101510000229	YCII-related domain; Region: YCII; cl00999
101510000230	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
101510000231	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
101510000232	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358
101510000233	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
101510000234	multiple promoter invertase; Provisional; Region: mpi; PRK13413
101510000235	catalytic residues [active]
101510000236	catalytic nucleophile [active]
101510000237	Presynaptic Site I dimer interface [polypeptide binding]; other site
101510000238	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
101510000239	Synaptic Flat tetramer interface [polypeptide binding]; other site
101510000240	Synaptic Site I dimer interface [polypeptide binding]; other site
101510000241	DNA binding site [nucleotide binding]
101510000242	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
101510000243	DNA-binding interface [nucleotide binding]; DNA binding site
101510000244	LGFP repeat; Region: LGFP; pfam08310
101510000245	LGFP repeat; Region: LGFP; pfam08310
101510000246	LGFP repeat; Region: LGFP; pfam08310
101510000247	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
101510000248	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
101510000249	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
101510000250	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510000251	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
101510000252	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
101510000253	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
101510000254	motif II; other site
101510000255	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
101510000256	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510000257	Protein of unknown function (DUF4235); Region: DUF4235; pfam14019
101510000258	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
101510000259	PhoU domain; Region: PhoU; pfam01895
101510000260	PhoU domain; Region: PhoU; pfam01895
101510000261	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510000262	S-adenosylmethionine binding site [chemical binding]; other site
101510000263	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
101510000264	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510000265	active site
101510000266	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
101510000267	active site
101510000268	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
101510000269	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
101510000270	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510000271	catalytic loop [active]
101510000272	iron binding site [ion binding]; other site
101510000273	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
101510000274	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
101510000275	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390
101510000276	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
101510000277	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
101510000278	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
101510000279	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
101510000280	DUF35 OB-fold domain; Region: DUF35; pfam01796
101510000281	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510000282	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510000283	DNA binding residues [nucleotide binding]
101510000284	dimerization interface [polypeptide binding]; other site
101510000285	oxidoreductase; Provisional; Region: PRK12743
101510000286	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510000287	NAD(P) binding site [chemical binding]; other site
101510000288	Secretory lipase; Region: LIP; pfam03583
101510000289	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
101510000290	peptide synthase; Provisional; Region: PRK12467
101510000291	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000292	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510000293	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000294	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510000295	peptide synthase; Provisional; Region: PRK12316
101510000296	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000297	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510000298	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
101510000299	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000300	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510000301	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000302	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510000303	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
101510000304	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000305	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510000306	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
101510000307	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000308	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510000309	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
101510000310	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
101510000311	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000312	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510000313	peptide synthase; Provisional; Region: PRK12467
101510000314	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000315	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510000316	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000317	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510000318	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
101510000319	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000320	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510000321	peptide synthase; Provisional; Region: PRK12467
101510000322	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000323	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510000324	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000325	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510000326	peptide synthase; Provisional; Region: PRK12467
101510000327	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000328	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510000329	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000330	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510000331	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
101510000332	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000333	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510000334	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
101510000335	Ligand binding site; other site
101510000336	Putative Catalytic site; other site
101510000337	DXD motif; other site
101510000338	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
101510000339	putative active site [active]
101510000340	catalytic triad [active]
101510000341	putative dimer interface [polypeptide binding]; other site
101510000342	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
101510000343	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
101510000344	active site
101510000345	FxsA cytoplasmic membrane protein; Region: FxsA; cl01148
101510000346	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
101510000347	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510000348	active site
101510000349	phosphorylation site [posttranslational modification]
101510000350	intermolecular recognition site; other site
101510000351	dimerization interface [polypeptide binding]; other site
101510000352	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510000353	DNA binding residues [nucleotide binding]
101510000354	dimerization interface [polypeptide binding]; other site
101510000355	FOG: CBS domain [General function prediction only]; Region: COG0517
101510000356	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
101510000357	lysine-ketoglutarate reductase/saccharopine dehydrogenase; Region: PLN02819
101510000358	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
101510000359	putative active site [active]
101510000360	PAS fold; Region: PAS_3; pfam08447
101510000361	heme pocket [chemical binding]; other site
101510000362	ANTAR domain; Region: ANTAR; cl04297
101510000363	Helix-turn-helix domains; Region: HTH; cl00088
101510000364	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
101510000365	Amino acid permease; Region: AA_permease; cl00524
101510000366	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
101510000367	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
101510000368	active site
101510000369	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
101510000370	Histidine kinase; Region: HisKA_3; pfam07730
101510000371	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
101510000372	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
101510000373	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
101510000374	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
101510000375	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
101510000376	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
101510000377	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
101510000378	ANTAR domain; Region: ANTAR; cl04297
101510000379	Protein of unknown function (DUF418); Region: DUF418; cl12135
101510000380	Protein of unknown function (DUF418); Region: DUF418; cl12135
101510000381	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
101510000382	Helix-turn-helix domains; Region: HTH; cl00088
101510000383	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
101510000384	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
101510000385	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
101510000386	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
101510000387	precorrin-3B synthase; Region: CobG; TIGR02435
101510000388	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
101510000389	Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913
101510000390	Precorrin-8X methylmutase; Region: CbiC; pfam02570
101510000391	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
101510000392	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
101510000393	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
101510000394	Transcriptional regulator [Transcription]; Region: LysR; COG0583
101510000395	Helix-turn-helix domains; Region: HTH; cl00088
101510000396	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
101510000397	dimerization interface [polypeptide binding]; other site
101510000398	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
101510000399	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
101510000400	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510000401	NAD(P) binding site [chemical binding]; other site
101510000402	active site
101510000403	Predicted transcriptional regulator [Transcription]; Region: COG1959
101510000404	Helix-turn-helix domains; Region: HTH; cl00088
101510000405	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
101510000406	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
101510000407	DNA binding residues [nucleotide binding]
101510000408	dimer interface [polypeptide binding]; other site
101510000409	[2Fe-2S] cluster binding site [ion binding]; other site
101510000410	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510000411	putative substrate translocation pore; other site
101510000412	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
101510000413	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
101510000414	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510000415	DNA binding residues [nucleotide binding]
101510000416	dimerization interface [polypeptide binding]; other site
101510000417	acyl-CoA synthetase; Validated; Region: PRK08162
101510000418	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000419	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000420	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000421	Chorismate mutase type II; Region: CM_2; cl00693
101510000422	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
101510000423	DoxX; Region: DoxX; cl00976
101510000424	probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621
101510000425	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510000426	RNA polymerase factor sigma-70; Validated; Region: PRK08241
101510000427	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
101510000428	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
101510000429	DNA binding residues [nucleotide binding]
101510000430	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510000431	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
101510000432	Strictosidine synthase; Region: Str_synth; pfam03088
101510000433	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
101510000434	Cupin domain; Region: Cupin_2; cl09118
101510000435	Cupin domain; Region: Cupin_2; cl09118
101510000436	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
101510000437	putative hydrophobic ligand binding site [chemical binding]; other site
101510000438	Gas vesicle protein; Region: Gas_vesicle; cl02954
101510000439	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
101510000440	Gas vesicle protein G; Region: GvpG; pfam05120
101510000441	Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800
101510000442	Gas vesicle protein; Region: Gas_vesicle; cl02954
101510000443	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
101510000444	Gas vesicle protein K; Region: GvpK; pfam05121
101510000445	CsbD-like; Region: CsbD; cl01888
101510000446	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
101510000447	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
101510000448	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
101510000449	classical (c) SDRs; Region: SDR_c; cd05233
101510000450	NAD(P) binding site [chemical binding]; other site
101510000451	active site
101510000452	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510000453	S-adenosylmethionine binding site [chemical binding]; other site
101510000454	putative oxidoreductase; Provisional; Region: PRK11579
101510000455	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510000456	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
101510000457	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
101510000458	First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt1; cd04772
101510000459	DNA binding residues [nucleotide binding]
101510000460	putative dimer interface [polypeptide binding]; other site
101510000461	Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt2; cd04773
101510000462	DNA binding residues [nucleotide binding]
101510000463	putative dimer interface [polypeptide binding]; other site
101510000464	magnesium protoporphyrin O-methyltransferase; Region: BchM-ChlM; TIGR02021
101510000465	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510000466	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510000467	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
101510000468	putative ligand binding site [chemical binding]; other site
101510000469	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
101510000470	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
101510000471	substrate binding pocket [chemical binding]; other site
101510000472	membrane-bound complex binding site; other site
101510000473	hinge residues; other site
101510000474	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
101510000475	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
101510000476	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
101510000477	peptide synthase; Validated; Region: PRK05691
101510000478	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000479	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510000480	peptide synthase; Provisional; Region: PRK12467
101510000481	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000482	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000483	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510000484	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000485	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510000486	peptide synthase; Provisional; Region: PRK12467
101510000487	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
101510000488	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000489	peptide synthase; Provisional; Region: PRK12467
101510000490	peptide synthase; Provisional; Region: PRK12467
101510000491	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000492	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000493	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510000494	peptide synthase; Validated; Region: PRK05691
101510000495	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
101510000496	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000497	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
101510000498	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510000499	peptide synthase; Provisional; Region: PRK12467
101510000500	L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443
101510000501	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000502	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
101510000503	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510000504	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
101510000505	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
101510000506	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000507	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510000508	classical (c) SDRs; Region: SDR_c; cd05233
101510000509	NAD(P) binding site [chemical binding]; other site
101510000510	active site
101510000511	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
101510000512	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883
101510000513	nucleophilic elbow; other site
101510000514	catalytic triad; other site
101510000515	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
101510000516	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
101510000517	active site
101510000518	DNA binding site [nucleotide binding]
101510000519	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
101510000520	DNA binding site [nucleotide binding]
101510000521	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
101510000522	nudix motif; other site
101510000523	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
101510000524	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
101510000525	active site
101510000526	catalytic tetrad [active]
101510000527	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
101510000528	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
101510000529	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510000530	oxidoreductase; Provisional; Region: PRK06128
101510000531	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510000532	NAD(P) binding site [chemical binding]; other site
101510000533	active site
101510000534	Clp protease ATP binding subunit; Region: clpC; CHL00095
101510000535	Clp amino terminal domain; Region: Clp_N; pfam02861
101510000536	Helix-turn-helix domains; Region: HTH; cl00088
101510000537	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529
101510000538	Predicted integral membrane protein [Function unknown]; Region: COG5522; cl02331
101510000539	rod shape-determining protein MreB; Provisional; Region: PRK13930
101510000540	Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528
101510000541	ATP binding site [chemical binding]; other site
101510000542	profilin binding site; other site
101510000543	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
101510000544	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
101510000545	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
101510000546	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
101510000547	Domain of unknown function (DUF1931); Region: DUF1931; pfam09123
101510000548	Amino acid permease; Region: AA_permease; cl00524
101510000549	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
101510000550	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
101510000551	FAD binding domain; Region: FAD_binding_4; pfam01565
101510000552	Berberine and berberine like; Region: BBE; pfam08031
101510000553	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
101510000554	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
101510000555	Protein of unknown function (DUF1688); Region: DUF1688; pfam07958
101510000556	hypothetical protein; Validated; Region: PRK07198
101510000557	GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471
101510000558	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
101510000559	dimerization interface [polypeptide binding]; other site
101510000560	active site
101510000561	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088
101510000562	HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008
101510000563	Helix-turn-helix domains; Region: HTH; cl00088
101510000564	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
101510000565	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
101510000566	Helix-turn-helix domains; Region: HTH; cl00088
101510000567	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
101510000568	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
101510000569	OsmC-like protein; Region: OsmC; cl00767
101510000570	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
101510000571	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
101510000572	active site
101510000573	non-prolyl cis peptide bond; other site
101510000574	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
101510000575	substrate binding pocket [chemical binding]; other site
101510000576	membrane-bound complex binding site; other site
101510000577	hinge residues; other site
101510000578	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
101510000579	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
101510000580	Walker A/P-loop; other site
101510000581	ATP binding site [chemical binding]; other site
101510000582	Q-loop/lid; other site
101510000583	ABC transporter signature motif; other site
101510000584	Walker B; other site
101510000585	D-loop; other site
101510000586	H-loop/switch region; other site
101510000587	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510000588	dimer interface [polypeptide binding]; other site
101510000589	conserved gate region; other site
101510000590	putative PBP binding loops; other site
101510000591	ABC-ATPase subunit interface; other site
101510000592	Transcriptional regulators [Transcription]; Region: GntR; COG1802
101510000593	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510000594	DNA-binding site [nucleotide binding]; DNA binding site
101510000595	FCD domain; Region: FCD; cl11656
101510000596	Protein of unknown function (DUF3105); Region: DUF3105; pfam11303
101510000597	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
101510000598	active site
101510000599	DsrE/DsrF-like family; Region: DrsE; cl00672
101510000600	Protein of unknown function (DUF867); Region: DUF867; cl01713
101510000601	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
101510000602	active site
101510000603	ATP binding site [chemical binding]; other site
101510000604	substrate binding site [chemical binding]; other site
101510000605	activation loop (A-loop); other site
101510000606	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
101510000607	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
101510000608	putative active site [active]
101510000609	putative metal binding site [ion binding]; other site
101510000610	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510000611	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510000612	active site
101510000613	ATP binding site [chemical binding]; other site
101510000614	substrate binding site [chemical binding]; other site
101510000615	activation loop (A-loop); other site
101510000616	Kelch motif; Region: Kelch_1; cl02701
101510000617	kelch-like protein; Provisional; Region: PHA03098
101510000618	Kelch motif; Region: Kelch_1; cl02701
101510000619	Kelch motif; Region: Kelch_1; cl02701
101510000620	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3055
101510000621	Kelch motif; Region: Kelch_1; cl02701
101510000622	Kelch motif; Region: Kelch_1; cl02701
101510000623	Kelch motif; Region: Kelch_1; cl02701
101510000624	Kelch motif; Region: Kelch_1; cl02701
101510000625	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
101510000626	I-site; other site
101510000627	active site
101510000628	metal binding site [ion binding]; metal-binding site
101510000629	TOBE domain; Region: TOBE_2; cl01440
101510000630	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
101510000631	Histidine kinase; Region: HisKA_3; pfam07730
101510000632	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510000633	ATP binding site [chemical binding]; other site
101510000634	Mg2+ binding site [ion binding]; other site
101510000635	G-X-G motif; other site
101510000636	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
101510000637	putative catalytic site [active]
101510000638	putative metal binding site [ion binding]; other site
101510000639	putative phosphate binding site [ion binding]; other site
101510000640	Uncharacterized conserved protein [Function unknown]; Region: COG5276
101510000641	Domain of unknown function (DUF305); Region: DUF305; pfam03713
101510000642	Domain of unknown function (DUF305); Region: DUF305; pfam03713
101510000643	gluconate 5-dehydrogenase; Provisional; Region: PRK06124
101510000644	classical (c) SDRs; Region: SDR_c; cd05233
101510000645	NAD(P) binding site [chemical binding]; other site
101510000646	active site
101510000647	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
101510000648	active site
101510000649	metal binding site [ion binding]; metal-binding site
101510000650	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510000651	Helicase associated domain; Region: HA; pfam03457
101510000652	Helicase associated domain; Region: HA; pfam03457
101510000653	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
101510000654	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
101510000655	conserved cys residue [active]
101510000656	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510000657	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510000658	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
101510000659	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
101510000660	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510000661	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510000662	putative substrate translocation pore; other site
101510000663	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
101510000664	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510000665	DNA-binding site [nucleotide binding]; DNA binding site
101510000666	UTRA domain; Region: UTRA; cl01230
101510000667	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510000668	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510000669	active site
101510000670	CoA-transferase family III; Region: CoA_transf_3; pfam02515
101510000671	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
101510000672	CoA-transferase family III; Region: CoA_transf_3; pfam02515
101510000673	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
101510000674	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
101510000675	putative active site [active]
101510000676	putative catalytic site [active]
101510000677	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510000678	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
101510000679	NAD(P) binding site [chemical binding]; other site
101510000680	catalytic residues [active]
101510000681	catalytic residues [active]
101510000682	Helix-turn-helix domains; Region: HTH; cl00088
101510000683	putative transposase OrfB; Reviewed; Region: PHA02517
101510000684	Integrase core domain; Region: rve; cl01316
101510000685	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510000686	oxyanion hole (OAH) forming residues; other site
101510000687	trimer interface [polypeptide binding]; other site
101510000688	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
101510000689	Integrase core domain; Region: rve; cl01316
101510000690	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
101510000691	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
101510000692	tetramer interface [polypeptide binding]; other site
101510000693	active site
101510000694	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
101510000695	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510000696	Helix-turn-helix domains; Region: HTH; cl00088
101510000697	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510000698	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510000699	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
101510000700	CoenzymeA binding site [chemical binding]; other site
101510000701	subunit interaction site [polypeptide binding]; other site
101510000702	PHB binding site; other site
101510000703	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510000704	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
101510000705	tartrate dehydrogenase; Provisional; Region: PRK08194
101510000706	Helix-turn-helix domains; Region: HTH; cl00088
101510000707	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510000708	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
101510000709	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614
101510000710	NAD(P) binding site [chemical binding]; other site
101510000711	Transcriptional regulators [Transcription]; Region: MarR; COG1846
101510000712	Helix-turn-helix domains; Region: HTH; cl00088
101510000713	Chlorite dismutase; Region: Chlor_dismutase; cl01280
101510000714	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
101510000715	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
101510000716	active site residue [active]
101510000717	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
101510000718	active site residue [active]
101510000719	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
101510000720	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
101510000721	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
101510000722	ANTAR domain; Region: ANTAR; cl04297
101510000723	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
101510000724	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
101510000725	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
101510000726	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
101510000727	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
101510000728	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510000729	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
101510000730	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
101510000731	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
101510000732	NAD(P) binding site [chemical binding]; other site
101510000733	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510000734	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
101510000735	tetrameric interface [polypeptide binding]; other site
101510000736	NAD binding site [chemical binding]; other site
101510000737	catalytic residues [active]
101510000738	Domain of unknown function (DUF1338); Region: DUF1338; cl02226
101510000739	Domain of unknown function (DUF1338); Region: DUF1338; cl02226
101510000740	Transcriptional regulator [Transcription]; Region: LysR; COG0583
101510000741	Helix-turn-helix domains; Region: HTH; cl00088
101510000742	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
101510000743	dimerization interface [polypeptide binding]; other site
101510000744	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
101510000745	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
101510000746	Amino acid permease; Region: AA_permease; cl00524
101510000747	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
101510000748	FAD binding domain; Region: FAD_binding_4; pfam01565
101510000749	sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168
101510000750	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510000751	DNA-binding site [nucleotide binding]; DNA binding site
101510000752	FCD domain; Region: FCD; cl11656
101510000753	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
101510000754	Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123
101510000755	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510000756	Glutamate binding site [chemical binding]; other site
101510000757	NAD binding site [chemical binding]; other site
101510000758	catalytic residues [active]
101510000759	Proline dehydrogenase; Region: Pro_dh; cl03282
101510000760	Protein of unknown function (DUF421); Region: DUF421; cl00990
101510000761	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
101510000762	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
101510000763	active site
101510000764	metal binding site [ion binding]; metal-binding site
101510000765	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
101510000766	DinB superfamily; Region: DinB_2; cl00986
101510000767	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
101510000768	coenzyme A binding site [chemical binding]; other site
101510000769	citrylCoA binding site [chemical binding]; other site
101510000770	oxalacetate binding site [chemical binding]; other site
101510000771	catalytic triad [active]
101510000772	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
101510000773	Cupin domain; Region: Cupin_2; cl09118
101510000774	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510000775	Haem-containing dehydratase; Region: Dehydratase_hem; pfam13816
101510000776	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
101510000777	indole acetimide hydrolase; Validated; Region: PRK07488
101510000778	nitrile hydratase, alpha subunit; Region: nitrile_alph; TIGR01323
101510000779	NHLP leader peptide domain; Region: TOMM_pelo; cl15464
101510000780	Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211
101510000781	nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486
101510000782	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
101510000783	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510000784	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
101510000785	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510000786	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510000787	enoyl-CoA hydratase; Provisional; Region: PRK08260
101510000788	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510000789	substrate binding site [chemical binding]; other site
101510000790	oxyanion hole (OAH) forming residues; other site
101510000791	trimer interface [polypeptide binding]; other site
101510000792	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
101510000793	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000794	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510000795	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
101510000796	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
101510000797	FMN-binding pocket [chemical binding]; other site
101510000798	flavin binding motif; other site
101510000799	phosphate binding motif [ion binding]; other site
101510000800	beta-alpha-beta structure motif; other site
101510000801	NAD binding pocket [chemical binding]; other site
101510000802	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510000803	catalytic loop [active]
101510000804	iron binding site [ion binding]; other site
101510000805	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
101510000806	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510000807	NAD(P) binding site [chemical binding]; other site
101510000808	active site
101510000809	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510000810	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510000811	Helix-turn-helix domains; Region: HTH; cl00088
101510000812	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
101510000813	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
101510000814	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510000815	NAD binding site [chemical binding]; other site
101510000816	catalytic residues [active]
101510000817	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
101510000818	classical (c) SDRs; Region: SDR_c; cd05233
101510000819	NAD(P) binding site [chemical binding]; other site
101510000820	active site
101510000821	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
101510000822	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
101510000823	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
101510000824	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
101510000825	[2Fe-2S] cluster binding site [ion binding]; other site
101510000826	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887
101510000827	putative alpha subunit interface [polypeptide binding]; other site
101510000828	putative active site [active]
101510000829	putative substrate binding site [chemical binding]; other site
101510000830	Fe binding site [ion binding]; other site
101510000831	Cytochrome P450; Region: p450; cl12078
101510000832	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
101510000833	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
101510000834	classical (c) SDRs; Region: SDR_c; cd05233
101510000835	NAD(P) binding site [chemical binding]; other site
101510000836	active site
101510000837	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
101510000838	benzoate transport; Region: 2A0115; TIGR00895
101510000839	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510000840	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
101510000841	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
101510000842	[2Fe-2S] cluster binding site [ion binding]; other site
101510000843	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887
101510000844	putative alpha subunit interface [polypeptide binding]; other site
101510000845	putative active site [active]
101510000846	putative substrate binding site [chemical binding]; other site
101510000847	Fe binding site [ion binding]; other site
101510000848	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
101510000849	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510000850	NAD binding site [chemical binding]; other site
101510000851	catalytic residues [active]
101510000852	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510000853	Helix-turn-helix domains; Region: HTH; cl00088
101510000854	Flavin Reductases; Region: FlaRed; cl00801
101510000855	Lipocalin-like domain; Region: Lipocalin_5; pfam13924
101510000856	lipid-transfer protein; Provisional; Region: PRK07855
101510000857	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
101510000858	active site
101510000859	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
101510000860	DUF35 OB-fold domain; Region: DUF35; pfam01796
101510000861	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
101510000862	classical (c) SDRs; Region: SDR_c; cd05233
101510000863	NAD(P) binding site [chemical binding]; other site
101510000864	active site
101510000865	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510000866	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
101510000867	Cytochrome P450; Region: p450; cl12078
101510000868	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
101510000869	CoA-transferase family III; Region: CoA_transf_3; pfam02515
101510000870	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
101510000871	CoA-transferase family III; Region: CoA_transf_3; pfam02515
101510000872	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
101510000873	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510000874	NAD binding site [chemical binding]; other site
101510000875	catalytic residues [active]
101510000876	lipid-transfer protein; Provisional; Region: PRK07855
101510000877	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
101510000878	active site
101510000879	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
101510000880	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
101510000881	DUF35 OB-fold domain; Region: DUF35; pfam01796
101510000882	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
101510000883	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
101510000884	active site
101510000885	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
101510000886	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
101510000887	enoyl-CoA hydratase; Provisional; Region: PRK05864
101510000888	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510000889	substrate binding site [chemical binding]; other site
101510000890	oxyanion hole (OAH) forming residues; other site
101510000891	trimer interface [polypeptide binding]; other site
101510000892	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394
101510000893	secoisolariciresinol dehydrogenase (secoisolariciresinol-DH)-like, classical (c) SDRs; Region: secoisolariciresinol-DH_like_SDR_c; cd05326
101510000894	NAD binding site [chemical binding]; other site
101510000895	homodimer interface [polypeptide binding]; other site
101510000896	substrate binding site [chemical binding]; other site
101510000897	active site
101510000898	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510000899	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510000900	putative substrate translocation pore; other site
101510000901	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510000902	NAD(P) binding site [chemical binding]; other site
101510000903	active site
101510000904	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
101510000905	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000906	ferredoxin-NADP+ reductase; Region: PLN02852
101510000907	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
101510000908	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510000909	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
101510000910	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
101510000911	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
101510000912	[2Fe-2S] cluster binding site [ion binding]; other site
101510000913	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887
101510000914	putative alpha subunit interface [polypeptide binding]; other site
101510000915	putative active site [active]
101510000916	putative substrate binding site [chemical binding]; other site
101510000917	Fe binding site [ion binding]; other site
101510000918	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510000919	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510000920	active site
101510000921	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
101510000922	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
101510000923	molybdopterin cofactor binding site; other site
101510000924	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
101510000925	molybdopterin cofactor binding site; other site
101510000926	Ferredoxin [Energy production and conversion]; Region: COG1146
101510000927	4Fe-4S binding domain; Region: Fer4; cl02805
101510000928	ferredoxin-NADP+ reductase; Region: PLN02852
101510000929	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
101510000930	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
101510000931	molybdopterin cofactor binding site; other site
101510000932	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
101510000933	molybdopterin cofactor binding site; other site
101510000934	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
101510000935	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
101510000936	molybdopterin cofactor binding site; other site
101510000937	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
101510000938	molybdopterin cofactor binding site; other site
101510000939	benzoate transport; Region: 2A0115; TIGR00895
101510000940	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510000941	putative substrate translocation pore; other site
101510000942	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
101510000943	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000944	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
101510000945	CoA-transferase family III; Region: CoA_transf_3; pfam02515
101510000946	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
101510000947	CoenzymeA binding site [chemical binding]; other site
101510000948	subunit interaction site [polypeptide binding]; other site
101510000949	PHB binding site; other site
101510000950	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
101510000951	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510000952	substrate binding site [chemical binding]; other site
101510000953	oxyanion hole (OAH) forming residues; other site
101510000954	trimer interface [polypeptide binding]; other site
101510000955	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
101510000956	[2Fe-2S] cluster binding site [ion binding]; other site
101510000957	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887
101510000958	putative alpha subunit interface [polypeptide binding]; other site
101510000959	putative active site [active]
101510000960	putative substrate binding site [chemical binding]; other site
101510000961	Fe binding site [ion binding]; other site
101510000962	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510000963	Helix-turn-helix domains; Region: HTH; cl00088
101510000964	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510000965	Helix-turn-helix domains; Region: HTH; cl00088
101510000966	Cytochrome P450; Region: p450; cl12078
101510000967	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
101510000968	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510000969	classical (c) SDRs; Region: SDR_c; cd05233
101510000970	NAD(P) binding site [chemical binding]; other site
101510000971	ferredoxin-NADP+ reductase; Region: PLN02852
101510000972	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
101510000973	Helix-turn-helix domains; Region: HTH; cl00088
101510000974	Helix-turn-helix domains; Region: HTH; cl00088
101510000975	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
101510000976	Helix-turn-helix domains; Region: HTH; cl00088
101510000977	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510000978	putative substrate translocation pore; other site
101510000979	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
101510000980	M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673
101510000981	amidohydrolase; Region: amidohydrolases; TIGR01891
101510000982	putative metal binding site [ion binding]; other site
101510000983	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
101510000984	amidohydrolase; Region: amidohydrolases; TIGR01891
101510000985	metal binding site [ion binding]; metal-binding site
101510000986	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
101510000987	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510000988	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510000989	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
101510000990	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
101510000991	putative NAD(P) binding site [chemical binding]; other site
101510000992	ANTAR domain; Region: ANTAR; cl04297
101510000993	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
101510000994	Helix-turn-helix domains; Region: HTH; cl00088
101510000995	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
101510000996	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
101510000997	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
101510000998	tetramer interface [polypeptide binding]; other site
101510000999	heme binding pocket [chemical binding]; other site
101510001000	NADPH binding site [chemical binding]; other site
101510001001	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
101510001002	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510001003	Walker A motif; other site
101510001004	ATP binding site [chemical binding]; other site
101510001005	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
101510001006	Helix-turn-helix domains; Region: HTH; cl00088
101510001007	Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057
101510001008	dimerization interface [polypeptide binding]; other site
101510001009	putative path to active site cavity [active]
101510001010	diiron center [ion binding]; other site
101510001011	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
101510001012	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510001013	catalytic loop [active]
101510001014	iron binding site [ion binding]; other site
101510001015	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. These flavoprotein monooxygenases use molecular oxygen as a substrate and require reduced FAD. One atom of oxygen is...; Region: monooxygenase_like; cd06212
101510001016	FAD binding pocket [chemical binding]; other site
101510001017	FAD binding motif [chemical binding]; other site
101510001018	phosphate binding motif [ion binding]; other site
101510001019	beta-alpha-beta structure motif; other site
101510001020	NAD binding pocket [chemical binding]; other site
101510001021	Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058
101510001022	dimerization interface [polypeptide binding]; other site
101510001023	MmoB/DmpM family; Region: MmoB_DmpM; pfam02406
101510001024	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
101510001025	active site
101510001026	Domain of unknown function DUF59; Region: DUF59; cl00941
101510001027	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
101510001028	D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284
101510001029	NAD binding site [chemical binding]; other site
101510001030	substrate binding site [chemical binding]; other site
101510001031	catalytic Zn binding site [ion binding]; other site
101510001032	structural Zn binding site [ion binding]; other site
101510001033	chaperonin GroEL; Reviewed; Region: groEL; PRK12850
101510001034	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
101510001035	ring oligomerisation interface [polypeptide binding]; other site
101510001036	ATP/Mg binding site [chemical binding]; other site
101510001037	stacking interactions; other site
101510001038	hinge regions; other site
101510001039	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
101510001040	FAD binding domain; Region: FAD_binding_4; pfam01565
101510001041	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
101510001042	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
101510001043	Helix-turn-helix domains; Region: HTH; cl00088
101510001044	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
101510001045	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510001046	NAD(P) binding site [chemical binding]; other site
101510001047	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
101510001048	active site
101510001049	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
101510001050	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510001051	S-adenosylmethionine binding site [chemical binding]; other site
101510001052	YCII-related domain; Region: YCII; cl00999
101510001053	MULE transposase domain; Region: MULE; pfam10551
101510001054	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
101510001055	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510001056	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
101510001057	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510001058	DNA binding site [nucleotide binding]
101510001059	Int/Topo IB signature motif; other site
101510001060	active site
101510001061	Transposase, Mutator family; Region: Transposase_mut; pfam00872
101510001062	Transposase, Mutator family; Region: Transposase_mut; pfam00872
101510001063	Protein of unknown function (DUF3445); Region: DUF3445; pfam11927
101510001064	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
101510001065	FMN-binding pocket [chemical binding]; other site
101510001066	flavin binding motif; other site
101510001067	phosphate binding motif [ion binding]; other site
101510001068	beta-alpha-beta structure motif; other site
101510001069	NAD binding pocket [chemical binding]; other site
101510001070	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510001071	catalytic loop [active]
101510001072	iron binding site [ion binding]; other site
101510001073	Cupin domain; Region: Cupin_2; cl09118
101510001074	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
101510001075	MOSC domain; Region: MOSC; pfam03473
101510001076	3-alpha domain; Region: 3-alpha; pfam03475
101510001077	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
101510001078	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
101510001079	FAD binding pocket [chemical binding]; other site
101510001080	FAD binding motif [chemical binding]; other site
101510001081	phosphate binding motif [ion binding]; other site
101510001082	beta-alpha-beta structure motif; other site
101510001083	NAD binding pocket [chemical binding]; other site
101510001084	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510001085	catalytic loop [active]
101510001086	iron binding site [ion binding]; other site
101510001087	MmoB/DmpM family; Region: MmoB_DmpM; pfam02406
101510001088	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
101510001089	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510001090	Zn binding site [ion binding]; other site
101510001091	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
101510001092	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
101510001093	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
101510001094	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668
101510001095	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
101510001096	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
101510001097	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510001098	salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255
101510001099	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510001100	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510001101	Helix-turn-helix domains; Region: HTH; cl00088
101510001102	Domain of unknown function (DUF385); Region: DUF385; cl04387
101510001103	ChaB; Region: ChaB; cl01887
101510001104	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
101510001105	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510001106	DNA binding residues [nucleotide binding]
101510001107	Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane]; Region: GutQ; COG0794
101510001108	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
101510001109	tetramer interface [polypeptide binding]; other site
101510001110	active site
101510001111	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
101510001112	active site
101510001113	magnesium binding site [ion binding]; other site
101510001114	dimer interface [polypeptide binding]; other site
101510001115	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
101510001116	Malic enzyme, N-terminal domain; Region: malic; pfam00390
101510001117	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
101510001118	putative NAD(P) binding site [chemical binding]; other site
101510001119	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510001120	Protein of unknown function (DUF1696); Region: DUF1696; pfam08000
101510001121	Protein of unknown function (DUF732); Region: DUF732; pfam05305
101510001122	Integrase core domain; Region: rve; cl01316
101510001123	Helix-turn-helix domains; Region: HTH; cl00088
101510001124	LCCL domain; Region: LCCL; cl02694
101510001125	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510001126	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510001127	active site
101510001128	ATP binding site [chemical binding]; other site
101510001129	substrate binding site [chemical binding]; other site
101510001130	activation loop (A-loop); other site
101510001131	NHL repeat; Region: NHL; pfam01436
101510001132	NHL repeat; Region: NHL; pfam01436
101510001133	NHL repeat; Region: NHL; pfam01436
101510001134	NHL repeat; Region: NHL; pfam01436
101510001135	Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719
101510001136	Protein of unknown function (DUF732); Region: DUF732; pfam05305
101510001137	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
101510001138	Helix-turn-helix domains; Region: HTH; cl00088
101510001139	DNA binding site [nucleotide binding]
101510001140	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
101510001141	phosphopeptide binding site; other site
101510001142	serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184
101510001143	Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015
101510001144	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
101510001145	GAF domain; Region: GAF; cl00853
101510001146	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
101510001147	metal binding site [ion binding]; metal-binding site
101510001148	active site
101510001149	I-site; other site
101510001150	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
101510001151	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510001152	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510001153	NAD(P) binding site [chemical binding]; other site
101510001154	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
101510001155	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
101510001156	active site
101510001157	catalytic residues [active]
101510001158	metal binding site [ion binding]; metal-binding site
101510001159	DmpG-like communication domain; Region: DmpG_comm; pfam07836
101510001160	acetaldehyde dehydrogenase; Validated; Region: PRK08300
101510001161	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510001162	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
101510001163	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
101510001164	Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365
101510001165	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
101510001166	putative active site [active]
101510001167	Fe(II) binding site [ion binding]; other site
101510001168	putative dimer interface [polypeptide binding]; other site
101510001169	putative tetramer interface [polypeptide binding]; other site
101510001170	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510001171	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510001172	FAD binding domain; Region: FAD_binding_3; pfam01494
101510001173	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
101510001174	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510001175	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510001176	putative substrate translocation pore; other site
101510001177	Transcriptional regulators [Transcription]; Region: GntR; COG1802
101510001178	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510001179	DNA-binding site [nucleotide binding]; DNA binding site
101510001180	FCD domain; Region: FCD; cl11656
101510001181	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
101510001182	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510001183	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
101510001184	Isochorismatase family; Region: Isochorismatase; pfam00857
101510001185	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
101510001186	catalytic triad [active]
101510001187	conserved cis-peptide bond; other site
101510001188	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
101510001189	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614
101510001190	NAD(P) binding site [chemical binding]; other site
101510001191	Transcription factor WhiB; Region: Whib; pfam02467
101510001192	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
101510001193	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
101510001194	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510001195	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
101510001196	putative FMN binding site [chemical binding]; other site
101510001197	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510001198	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510001199	active site
101510001200	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
101510001201	Flavin Reductases; Region: FlaRed; cl00801
101510001202	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
101510001203	The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6,  and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348
101510001204	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510001205	putative active site [active]
101510001206	putative metal binding site [ion binding]; other site
101510001207	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
101510001208	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
101510001209	FAD binding domain; Region: FAD_binding_3; pfam01494
101510001210	hypothetical protein; Provisional; Region: PRK08244
101510001211	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510001212	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
101510001213	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
101510001214	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510001215	Transcriptional regulators [Transcription]; Region: GntR; COG1802
101510001216	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510001217	DNA-binding site [nucleotide binding]; DNA binding site
101510001218	FCD domain; Region: FCD; cl11656
101510001219	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
101510001220	Helix-turn-helix domains; Region: HTH; cl00088
101510001221	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
101510001222	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
101510001223	TPP-binding site [chemical binding]; other site
101510001224	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
101510001225	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
101510001226	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
101510001227	E3 interaction surface; other site
101510001228	lipoyl attachment site [posttranslational modification]; other site
101510001229	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
101510001230	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
101510001231	Transcription factor WhiB; Region: Whib; pfam02467
101510001232	Epoxide hydrolase N terminus; Region: EHN; pfam06441
101510001233	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510001234	active site
101510001235	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
101510001236	catalytic core [active]
101510001237	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
101510001238	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
101510001239	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
101510001240	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
101510001241	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510001242	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490
101510001243	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
101510001244	Cupin domain; Region: Cupin_2; cl09118
101510001245	Helix-turn-helix domains; Region: HTH; cl00088
101510001246	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
101510001247	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
101510001248	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510001249	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
101510001250	dimer interface [polypeptide binding]; other site
101510001251	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510001252	Major Facilitator Superfamily; Region: MFS_1; pfam07690
101510001253	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510001254	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510001255	Helix-turn-helix domains; Region: HTH; cl00088
101510001256	Cupin domain; Region: Cupin_2; cl09118
101510001257	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
101510001258	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
101510001259	active site
101510001260	catalytic tetrad [active]
101510001261	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
101510001262	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510001263	putative substrate translocation pore; other site
101510001264	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
101510001265	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
101510001266	catalytic Zn binding site [ion binding]; other site
101510001267	NAD(P) binding site [chemical binding]; other site
101510001268	structural Zn binding site [ion binding]; other site
101510001269	Helix-turn-helix domains; Region: HTH; cl00088
101510001270	hypothetical protein; Provisional; Region: PRK11171
101510001271	Cupin domain; Region: Cupin_2; cl09118
101510001272	Cupin domain; Region: Cupin_2; cl09118
101510001273	Helix-turn-helix domains; Region: HTH; cl00088
101510001274	LexA repressor; Validated; Region: PRK00215
101510001275	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
101510001276	Catalytic site [active]
101510001277	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
101510001278	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
101510001279	NAD(P) binding site [chemical binding]; other site
101510001280	Transcriptional regulator [Transcription]; Region: LysR; COG0583
101510001281	Helix-turn-helix domains; Region: HTH; cl00088
101510001282	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
101510001283	putative dimerization interface [polypeptide binding]; other site
101510001284	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510001285	hypothetical protein; Provisional; Region: PRK06185
101510001286	Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428
101510001287	Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696
101510001288	YCII-related domain; Region: YCII; cl00999
101510001289	Protein of unknown function (DUF419); Region: DUF419; cl15265
101510001290	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
101510001291	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
101510001292	putative NAD(P) binding site [chemical binding]; other site
101510001293	DoxX; Region: DoxX; cl00976
101510001294	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
101510001295	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
101510001296	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
101510001297	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510001298	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
101510001299	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510001300	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
101510001301	NAD(P) binding site [chemical binding]; other site
101510001302	catalytic residues [active]
101510001303	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
101510001304	DNA-binding site [nucleotide binding]; DNA binding site
101510001305	RNA-binding motif; other site
101510001306	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510001307	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510001308	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
101510001309	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
101510001310	active site
101510001311	catalytic tetrad [active]
101510001312	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
101510001313	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
101510001314	active site
101510001315	dimer interface [polypeptide binding]; other site
101510001316	non-prolyl cis peptide bond; other site
101510001317	insertion regions; other site
101510001318	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
101510001319	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
101510001320	Coenzyme A binding pocket [chemical binding]; other site
101510001321	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
101510001322	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
101510001323	dimer interface [polypeptide binding]; other site
101510001324	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510001325	catalytic residue [active]
101510001326	Transcription factor WhiB; Region: Whib; pfam02467
101510001327	Transcriptional regulators [Transcription]; Region: GntR; COG1802
101510001328	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510001329	DNA-binding site [nucleotide binding]; DNA binding site
101510001330	FCD domain; Region: FCD; cl11656
101510001331	cytosine deaminase; Provisional; Region: PRK05985
101510001332	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
101510001333	active site
101510001334	Amino acid permease; Region: AA_permease; cl00524
101510001335	cytosine deaminase; Provisional; Region: PRK05985
101510001336	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
101510001337	active site
101510001338	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
101510001339	RNA polymerase sigma factor SigL; Provisional; Region: PRK09645
101510001340	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
101510001341	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
101510001342	DNA binding residues [nucleotide binding]
101510001343	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
101510001344	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
101510001345	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
101510001346	putative heme binding pocket [chemical binding]; other site
101510001347	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
101510001348	Leucine carboxyl methyltransferase; Region: LCM; cl01306
101510001349	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
101510001350	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510001351	YCII-related domain; Region: YCII; cl00999
101510001352	Uncharacterized conserved protein [Function unknown]; Region: COG4832
101510001353	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368
101510001354	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368
101510001355	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
101510001356	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
101510001357	dimer interface [polypeptide binding]; other site
101510001358	active site
101510001359	catalytic residue [active]
101510001360	Clp protease ATP binding subunit; Region: clpC; CHL00095
101510001361	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
101510001362	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510001363	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
101510001364	Predicted membrane protein [Function unknown]; Region: COG1289
101510001365	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
101510001366	non-specific DNA binding site [nucleotide binding]; other site
101510001367	salt bridge; other site
101510001368	sequence-specific DNA binding site [nucleotide binding]; other site
101510001369	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510001370	Cutinase; Region: Cutinase; cl15711
101510001371	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
101510001372	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
101510001373	2-enoyl thioester reductase-like; Region: ETR_like; cd05282
101510001374	NADP binding site [chemical binding]; other site
101510001375	dimer interface [polypeptide binding]; other site
101510001376	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
101510001377	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510001378	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
101510001379	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
101510001380	metal binding site [ion binding]; metal-binding site
101510001381	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
101510001382	active site
101510001383	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
101510001384	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
101510001385	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
101510001386	protein binding site [polypeptide binding]; other site
101510001387	Ion channel; Region: Ion_trans_2; cl11596
101510001388	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
101510001389	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510001390	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
101510001391	Amino acid permease; Region: AA_permease; cl00524
101510001392	YCII-related domain; Region: YCII; cl00999
101510001393	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
101510001394	iron-sulfur cluster [ion binding]; other site
101510001395	[2Fe-2S] cluster binding site [ion binding]; other site
101510001396	HicB family; Region: HicB; pfam05534
101510001397	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
101510001398	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
101510001399	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510001400	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
101510001401	NAD(P) binding site [chemical binding]; other site
101510001402	catalytic residues [active]
101510001403	Cupin domain; Region: Cupin_2; cl09118
101510001404	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
101510001405	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
101510001406	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
101510001407	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
101510001408	Ligand Binding Site [chemical binding]; other site
101510001409	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
101510001410	Citrate transporter; Region: CitMHS; pfam03600
101510001411	Transcriptional regulators [Transcription]; Region: GntR; COG1802
101510001412	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510001413	DNA-binding site [nucleotide binding]; DNA binding site
101510001414	FCD domain; Region: FCD; cl11656
101510001415	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
101510001416	Integrase core domain; Region: rve; cl01316
101510001417	transposase/IS protein; Provisional; Region: PRK09183
101510001418	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
101510001419	Walker A motif; other site
101510001420	ATP binding site [chemical binding]; other site
101510001421	Walker B motif; other site
101510001422	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510001423	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
101510001424	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510001425	DNA binding site [nucleotide binding]
101510001426	Int/Topo IB signature motif; other site
101510001427	active site
101510001428	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510001429	putative transposase OrfB; Reviewed; Region: PHA02517
101510001430	Integrase core domain; Region: rve; cl01316
101510001431	Helix-turn-helix domains; Region: HTH; cl00088
101510001432	PAS fold; Region: PAS_3; pfam08447
101510001433	ANTAR domain; Region: ANTAR; cl04297
101510001434	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
101510001435	Gas vesicle protein; Region: Gas_vesicle; cl02954
101510001436	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
101510001437	putative hydrophobic ligand binding site [chemical binding]; other site
101510001438	PAS domain S-box; Region: sensory_box; TIGR00229
101510001439	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
101510001440	metal binding site [ion binding]; metal-binding site
101510001441	active site
101510001442	I-site; other site
101510001443	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
101510001444	Gas vesicle protein; Region: Gas_vesicle; cl02954
101510001445	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
101510001446	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510001447	active site
101510001448	ATP binding site [chemical binding]; other site
101510001449	substrate binding site [chemical binding]; other site
101510001450	activation loop (A-loop); other site
101510001451	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
101510001452	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
101510001453	hydrophobic ligand binding site; other site
101510001454	CHAD domain; Region: CHAD; cl10506
101510001455	Gas vesicle protein; Region: Gas_vesicle; cl02954
101510001456	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
101510001457	sensory histidine kinase AtoS; Provisional; Region: PRK11360
101510001458	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
101510001459	putative hydrophobic ligand binding site [chemical binding]; other site
101510001460	Gas vesicle protein; Region: Gas_vesicle; cl02954
101510001461	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
101510001462	Gas vesicle protein G; Region: GvpG; pfam05120
101510001463	Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800
101510001464	Gas vesicle protein; Region: Gas_vesicle; cl02954
101510001465	Gas vesicle protein; Region: Gas_vesicle; cl02954
101510001466	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510001467	Helix-turn-helix domains; Region: HTH; cl00088
101510001468	2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030
101510001469	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
101510001470	dimer interface [polypeptide binding]; other site
101510001471	PYR/PP interface [polypeptide binding]; other site
101510001472	TPP binding site [chemical binding]; other site
101510001473	substrate binding site [chemical binding]; other site
101510001474	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
101510001475	TPP-binding site; other site
101510001476	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
101510001477	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
101510001478	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
101510001479	substrate binding site [chemical binding]; other site
101510001480	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
101510001481	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
101510001482	substrate binding site [chemical binding]; other site
101510001483	ligand binding site [chemical binding]; other site
101510001484	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
101510001485	Helix-turn-helix domains; Region: HTH; cl00088
101510001486	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
101510001487	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
101510001488	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
101510001489	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
101510001490	putative di-iron ligands [ion binding]; other site
101510001491	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
101510001492	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
101510001493	FAD binding pocket [chemical binding]; other site
101510001494	FAD binding motif [chemical binding]; other site
101510001495	phosphate binding motif [ion binding]; other site
101510001496	beta-alpha-beta structure motif; other site
101510001497	NAD(p) ribose binding residues [chemical binding]; other site
101510001498	NAD binding pocket [chemical binding]; other site
101510001499	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
101510001500	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510001501	catalytic loop [active]
101510001502	iron binding site [ion binding]; other site
101510001503	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
101510001504	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510001505	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510001506	DNA binding residues [nucleotide binding]
101510001507	dimerization interface [polypeptide binding]; other site
101510001508	C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716
101510001509	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510001510	S-adenosylmethionine binding site [chemical binding]; other site
101510001511	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
101510001512	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510001513	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510001514	NAD(P) binding pocket [chemical binding]; other site
101510001515	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
101510001516	catalytic residues [active]
101510001517	catalytic nucleophile [active]
101510001518	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353
101510001519	putative dimer interface [polypeptide binding]; other site
101510001520	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510001521	putative transposase OrfB; Reviewed; Region: PHA02517
101510001522	Integrase core domain; Region: rve; cl01316
101510001523	putative transposase OrfB; Reviewed; Region: PHA02517
101510001524	Integrase core domain; Region: rve; cl01316
101510001525	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
101510001526	hydrophobic ligand binding site; other site
101510001527	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
101510001528	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
101510001529	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088
101510001530	Transposase; Region: DEDD_Tnp_IS110; pfam01548
101510001531	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
101510001532	Domain of unknown function (DUF385); Region: DUF385; cl04387
101510001533	poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839
101510001534	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
101510001535	poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240
101510001536	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510001537	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510001538	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510001539	active site
101510001540	ATP binding site [chemical binding]; other site
101510001541	substrate binding site [chemical binding]; other site
101510001542	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
101510001543	substrate binding site [chemical binding]; other site
101510001544	activation loop (A-loop); other site
101510001545	activation loop (A-loop); other site
101510001546	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510001547	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
101510001548	TPR motif; other site
101510001549	binding surface
101510001550	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510001551	DNA binding residues [nucleotide binding]
101510001552	dimerization interface [polypeptide binding]; other site
101510001553	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510001554	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510001555	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
101510001556	active site
101510001557	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
101510001558	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
101510001559	active site 2 [active]
101510001560	active site 1 [active]
101510001561	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
101510001562	active site 2 [active]
101510001563	active site 1 [active]
101510001564	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
101510001565	CoA-transferase family III; Region: CoA_transf_3; pfam02515
101510001566	Cupin domain; Region: Cupin_2; cl09118
101510001567	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510001568	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510001569	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510001570	Helix-turn-helix domains; Region: HTH; cl00088
101510001571	ATP-grasp domain; Region: ATP-grasp_4; cl03087
101510001572	Uncharacterised protein family (UPF0158); Region: UPF0158; pfam03682
101510001573	Transcriptional regulator [Transcription]; Region: LysR; COG0583
101510001574	Helix-turn-helix domains; Region: HTH; cl00088
101510001575	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
101510001576	putative dimerization interface [polypeptide binding]; other site
101510001577	Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158
101510001578	PrpF protein; Region: PrpF; pfam04303
101510001579	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
101510001580	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
101510001581	Helix-turn-helix domains; Region: HTH; cl00088
101510001582	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
101510001583	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
101510001584	putative dimerization interface [polypeptide binding]; other site
101510001585	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
101510001586	CoA-transferase family III; Region: CoA_transf_3; pfam02515
101510001587	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
101510001588	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510001589	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
101510001590	Cupin domain; Region: Cupin_2; cl09118
101510001591	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
101510001592	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
101510001593	putative NAD(P) binding site [chemical binding]; other site
101510001594	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
101510001595	DinB superfamily; Region: DinB_2; cl00986
101510001596	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
101510001597	Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516
101510001598	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
101510001599	CGNR zinc finger; Region: zf-CGNR; pfam11706
101510001600	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510001601	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510001602	DNA binding residues [nucleotide binding]
101510001603	dimerization interface [polypeptide binding]; other site
101510001604	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
101510001605	DinB superfamily; Region: DinB_2; cl00986
101510001606	benzoate transport; Region: 2A0115; TIGR00895
101510001607	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
101510001608	dimer interface [polypeptide binding]; other site
101510001609	FMN binding site [chemical binding]; other site
101510001610	NADPH bind site [chemical binding]; other site
101510001611	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
101510001612	classical (c) SDRs; Region: SDR_c; cd05233
101510001613	NAD(P) binding site [chemical binding]; other site
101510001614	active site
101510001615	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
101510001616	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
101510001617	putative active site [active]
101510001618	putative NTP binding site [chemical binding]; other site
101510001619	putative nucleic acid binding site [nucleotide binding]; other site
101510001620	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
101510001621	homotrimer interaction site [polypeptide binding]; other site
101510001622	putative active site [active]
101510001623	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
101510001624	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
101510001625	Walker A/P-loop; other site
101510001626	ATP binding site [chemical binding]; other site
101510001627	Q-loop/lid; other site
101510001628	ABC transporter signature motif; other site
101510001629	Walker B; other site
101510001630	D-loop; other site
101510001631	H-loop/switch region; other site
101510001632	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
101510001633	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510001634	dimer interface [polypeptide binding]; other site
101510001635	conserved gate region; other site
101510001636	putative PBP binding loops; other site
101510001637	ABC-ATPase subunit interface; other site
101510001638	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
101510001639	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
101510001640	phosphate binding site [ion binding]; other site
101510001641	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
101510001642	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
101510001643	Transcriptional regulator [Transcription]; Region: LysR; COG0583
101510001644	Helix-turn-helix domains; Region: HTH; cl00088
101510001645	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
101510001646	dimerization interface [polypeptide binding]; other site
101510001647	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
101510001648	Nitronate monooxygenase; Region: NMO; pfam03060
101510001649	FMN binding site [chemical binding]; other site
101510001650	substrate binding site [chemical binding]; other site
101510001651	putative catalytic residue [active]
101510001652	Transcriptional regulator [Transcription]; Region: LysR; COG0583
101510001653	Helix-turn-helix domains; Region: HTH; cl00088
101510001654	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
101510001655	dimerization interface [polypeptide binding]; other site
101510001656	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
101510001657	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510001658	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510001659	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510001660	putative substrate translocation pore; other site
101510001661	Nitronate monooxygenase; Region: NMO; pfam03060
101510001662	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
101510001663	FMN binding site [chemical binding]; other site
101510001664	substrate binding site [chemical binding]; other site
101510001665	putative catalytic residue [active]
101510001666	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
101510001667	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
101510001668	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
101510001669	PYR/PP interface [polypeptide binding]; other site
101510001670	dimer interface [polypeptide binding]; other site
101510001671	TPP binding site [chemical binding]; other site
101510001672	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
101510001673	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
101510001674	TPP-binding site [chemical binding]; other site
101510001675	dimer interface [polypeptide binding]; other site
101510001676	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510001677	Helix-turn-helix domains; Region: HTH; cl00088
101510001678	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510001679	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
101510001680	putative ligand binding site [chemical binding]; other site
101510001681	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
101510001682	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
101510001683	Walker A/P-loop; other site
101510001684	ATP binding site [chemical binding]; other site
101510001685	Q-loop/lid; other site
101510001686	ABC transporter signature motif; other site
101510001687	Walker B; other site
101510001688	D-loop; other site
101510001689	H-loop/switch region; other site
101510001690	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
101510001691	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
101510001692	TM-ABC transporter signature motif; other site
101510001693	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510001694	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
101510001695	tetramerization interface [polypeptide binding]; other site
101510001696	NAD(P) binding site [chemical binding]; other site
101510001697	catalytic residues [active]
101510001698	progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948
101510001699	NAD(P) binding site [chemical binding]; other site
101510001700	active site
101510001701	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510001702	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
101510001703	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510001704	Cupin domain; Region: Cupin_2; cl09118
101510001705	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
101510001706	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922
101510001707	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
101510001708	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
101510001709	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
101510001710	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510001711	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
101510001712	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510001713	NAD(P) binding site [chemical binding]; other site
101510001714	active site
101510001715	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
101510001716	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
101510001717	Ligand binding site; other site
101510001718	Putative Catalytic site; other site
101510001719	DXD motif; other site
101510001720	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
101510001721	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
101510001722	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
101510001723	active site
101510001724	5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739
101510001725	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
101510001726	active site
101510001727	metal binding site 1 [ion binding]; metal-binding site
101510001728	putative 5' ssDNA interaction site; other site
101510001729	metal binding site 3; metal-binding site
101510001730	metal binding site 2 [ion binding]; metal-binding site
101510001731	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
101510001732	putative DNA binding site [nucleotide binding]; other site
101510001733	putative metal binding site [ion binding]; other site
101510001734	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
101510001735	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
101510001736	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
101510001737	ATP binding site [chemical binding]; other site
101510001738	putative Mg++ binding site [ion binding]; other site
101510001739	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
101510001740	nucleotide binding region [chemical binding]; other site
101510001741	ATP-binding site [chemical binding]; other site
101510001742	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
101510001743	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
101510001744	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
101510001745	2-dehydropantoate 2-reductase; Provisional; Region: PRK08229
101510001746	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510001747	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
101510001748	Predicted transcriptional regulator [Transcription]; Region: COG2378
101510001749	Predicted transcriptional regulator [Transcription]; Region: COG2378
101510001750	Pup-ligase protein; Region: Pup_ligase; cl15463
101510001751	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
101510001752	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
101510001753	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
101510001754	proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691
101510001755	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
101510001756	active site
101510001757	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
101510001758	active site
101510001759	Pup-like protein; Region: Pup; cl05289
101510001760	Pup-ligase protein; Region: Pup_ligase; cl15463
101510001761	Domain of unknown function (DUF385); Region: DUF385; cl04387
101510001762	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
101510001763	nudix motif; other site
101510001764	proteasome ATPase; Region: pup_AAA; TIGR03689
101510001765	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
101510001766	Walker A motif; other site
101510001767	ATP binding site [chemical binding]; other site
101510001768	Walker B motif; other site
101510001769	arginine finger; other site
101510001770	Filamin/ABP280 repeat; Region: Filamin; cl02665
101510001771	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
101510001772	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510001773	S-adenosylmethionine binding site [chemical binding]; other site
101510001774	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
101510001775	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
101510001776	active site 2 [active]
101510001777	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
101510001778	ATP phosphoribosyltransferase; Region: HisG; cl15266
101510001779	HisG, C-terminal domain; Region: HisG_C; cl06867
101510001780	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
101510001781	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
101510001782	PSRA_1: Pseudouridine synthase, a subgroup of the RluA family. This group is comprised of bacterial proteins assigned to the RluA family of pseudouridine synthases. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PSRA_1; cd02558
101510001783	probable active site [active]
101510001784	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
101510001785	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
101510001786	active site residue [active]
101510001787	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
101510001788	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
101510001789	motif II; other site
101510001790	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
101510001791	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
101510001792	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
101510001793	substrate binding pocket [chemical binding]; other site
101510001794	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
101510001795	B12 binding site [chemical binding]; other site
101510001796	cobalt ligand [ion binding]; other site
101510001797	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
101510001798	PAC2 family; Region: PAC2; cl00847
101510001799	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510001800	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
101510001801	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510001802	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
101510001803	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
101510001804	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
101510001805	iron-sulfur cluster [ion binding]; other site
101510001806	[2Fe-2S] cluster binding site [ion binding]; other site
101510001807	OpgC protein; Region: OpgC_C; cl00792
101510001808	Protein of unknown function (DUF3224); Region: DUF3224; pfam11528
101510001809	Helix-turn-helix domain; Region: HTH_18; pfam12833
101510001810	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
101510001811	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
101510001812	non-specific DNA binding site [nucleotide binding]; other site
101510001813	salt bridge; other site
101510001814	sequence-specific DNA binding site [nucleotide binding]; other site
101510001815	Cupin domain; Region: Cupin_2; cl09118
101510001816	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510001817	S-adenosylmethionine binding site [chemical binding]; other site
101510001818	Protein of unknown function (DUF2397); Region: DUF2397; pfam09660
101510001819	TIGR02677 family protein; Region: TIGR02677
101510001820	Protein of unknown function (DUF2398); Region: DUF2398; cl09875
101510001821	TIGR02680 family protein; Region: TIGR02680
101510001822	Transposase domain (DUF772); Region: DUF772; cl12084
101510001823	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
101510001824	cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447
101510001825	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
101510001826	active site
101510001827	HIGH motif; other site
101510001828	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
101510001829	active site
101510001830	KMSKS motif; other site
101510001831	Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955
101510001832	putative tRNA binding surface [nucleotide binding]; other site
101510001833	Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119
101510001834	Protein of unknown function (DUF3090); Region: DUF3090; cl12832
101510001835	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
101510001836	catalytic core [active]
101510001837	Bacitracin resistance protein BacA; Region: BacA; cl00858
101510001838	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
101510001839	active site
101510001840	catalytic tetrad [active]
101510001841	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
101510001842	heme binding pocket [chemical binding]; other site
101510001843	heme ligand [chemical binding]; other site
101510001844	ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558
101510001845	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
101510001846	intersubunit interface [polypeptide binding]; other site
101510001847	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
101510001848	dimer interface [polypeptide binding]; other site
101510001849	putative PBP binding regions; other site
101510001850	ABC-ATPase subunit  interface; other site
101510001851	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
101510001852	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
101510001853	Walker A/P-loop; other site
101510001854	ATP binding site [chemical binding]; other site
101510001855	Q-loop/lid; other site
101510001856	ABC transporter signature motif; other site
101510001857	Walker B; other site
101510001858	D-loop; other site
101510001859	H-loop/switch region; other site
101510001860	Glycyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: GRS1; COG0423
101510001861	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
101510001862	quinone interaction residues [chemical binding]; other site
101510001863	Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167
101510001864	active site
101510001865	catalytic residues [active]
101510001866	FMN binding site [chemical binding]; other site
101510001867	substrate binding site [chemical binding]; other site
101510001868	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
101510001869	substrate binding site [chemical binding]; other site
101510001870	hypothetical protein; Provisional; Region: PRK07906
101510001871	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
101510001872	putative metal binding site [ion binding]; other site
101510001873	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510001874	NAD(P) binding site [chemical binding]; other site
101510001875	short chain dehydrogenase; Provisional; Region: PRK12828
101510001876	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510001877	active site
101510001878	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
101510001879	Ligand Binding Site [chemical binding]; other site
101510001880	Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861
101510001881	Uncharacterized conserved protein [Function unknown]; Region: COG3268
101510001882	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
101510001883	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
101510001884	active site
101510001885	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
101510001886	metal ion-dependent adhesion site (MIDAS); other site
101510001887	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
101510001888	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
101510001889	putative active site [active]
101510001890	putative metal binding site [ion binding]; other site
101510001891	glycine dehydrogenase; Provisional; Region: PRK05367
101510001892	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
101510001893	tetramer interface [polypeptide binding]; other site
101510001894	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510001895	catalytic residue [active]
101510001896	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
101510001897	tetramer interface [polypeptide binding]; other site
101510001898	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510001899	catalytic residue [active]
101510001900	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
101510001901	DNA binding residues [nucleotide binding]
101510001902	putative dimer interface [polypeptide binding]; other site
101510001903	Uncharacterised ACR, COG1259; Region: DUF151; cl00553
101510001904	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
101510001905	DNA binding residues [nucleotide binding]
101510001906	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
101510001907	phosphopeptide binding site; other site
101510001908	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
101510001909	lipoyl attachment site [posttranslational modification]; other site
101510001910	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
101510001911	Protein of unknown function (DUF1290); Region: DUF1290; cl01587
101510001912	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
101510001913	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
101510001914	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
101510001915	Strictosidine synthase; Region: Str_synth; pfam03088
101510001916	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
101510001917	putative active site [active]
101510001918	putative CoA binding site [chemical binding]; other site
101510001919	nudix motif; other site
101510001920	metal binding site [ion binding]; metal-binding site
101510001921	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510001922	acyl-CoA synthetase; Validated; Region: PRK06188
101510001923	Uncharacterized conserved protein [Function unknown]; Region: COG3268
101510001924	classical (c) SDRs; Region: SDR_c; cd05233
101510001925	NAD(P) binding site [chemical binding]; other site
101510001926	active site
101510001927	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510001928	Helix-turn-helix domains; Region: HTH; cl00088
101510001929	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865
101510001930	putative hydrophobic ligand binding site [chemical binding]; other site
101510001931	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
101510001932	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510001933	putative substrate translocation pore; other site
101510001934	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
101510001935	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
101510001936	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
101510001937	GTP-binding protein Der; Reviewed; Region: PRK03003
101510001938	EngA1 subfamily.  This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains.  Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA1; cd01894
101510001939	G1 box; other site
101510001940	GTP/Mg2+ binding site [chemical binding]; other site
101510001941	Switch I region; other site
101510001942	G2 box; other site
101510001943	Switch II region; other site
101510001944	G3 box; other site
101510001945	G4 box; other site
101510001946	G5 box; other site
101510001947	EngA2 subfamily.  This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains.  Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA2; cd01895
101510001948	G1 box; other site
101510001949	GTP/Mg2+ binding site [chemical binding]; other site
101510001950	Switch I region; other site
101510001951	G2 box; other site
101510001952	G3 box; other site
101510001953	Switch II region; other site
101510001954	G4 box; other site
101510001955	G5 box; other site
101510001956	cytidylate kinase; Provisional; Region: cmk; PRK00023
101510001957	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
101510001958	CMP-binding site; other site
101510001959	The sites determining sugar specificity; other site
101510001960	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
101510001961	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
101510001962	RNA binding surface [nucleotide binding]; other site
101510001963	Pseudouridine synthases  are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870
101510001964	active site
101510001965	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
101510001966	ScpA/B protein; Region: ScpA_ScpB; cl00598
101510001967	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
101510001968	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
101510001969	P-loop; other site
101510001970	Magnesium ion binding site [ion binding]; other site
101510001971	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
101510001972	Magnesium ion binding site [ion binding]; other site
101510001973	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
101510001974	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510001975	DNA binding site [nucleotide binding]
101510001976	Int/Topo IB signature motif; other site
101510001977	active site
101510001978	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
101510001979	dimer interface [polypeptide binding]; other site
101510001980	active site
101510001981	ADP-ribose binding site [chemical binding]; other site
101510001982	nudix motif; other site
101510001983	metal binding site [ion binding]; metal-binding site
101510001984	CTP synthetase; Validated; Region: pyrG; PRK05380
101510001985	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
101510001986	Catalytic site [active]
101510001987	active site
101510001988	UTP binding site [chemical binding]; other site
101510001989	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
101510001990	active site
101510001991	putative oxyanion hole; other site
101510001992	catalytic triad [active]
101510001993	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
101510001994	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
101510001995	Thiamin pyrophosphokinase, catalytic domain; Region: TPK_catalytic; cl09135
101510001996	Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555
101510001997	DNA repair protein RecN; Region: recN; TIGR00634
101510001998	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
101510001999	Walker A/P-loop; other site
101510002000	ATP binding site [chemical binding]; other site
101510002001	Q-loop/lid; other site
101510002002	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
101510002003	ABC transporter signature motif; other site
101510002004	Walker B; other site
101510002005	D-loop; other site
101510002006	H-loop/switch region; other site
101510002007	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
101510002008	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
101510002009	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510002010	S-adenosylmethionine binding site [chemical binding]; other site
101510002011	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
101510002012	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
101510002013	motif II; other site
101510002014	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
101510002015	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
101510002016	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
101510002017	active site
101510002018	HIGH motif; other site
101510002019	dimer interface [polypeptide binding]; other site
101510002020	KMSKS motif; other site
101510002021	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
101510002022	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
101510002023	active site
101510002024	DNA binding site [nucleotide binding]
101510002025	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
101510002026	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
101510002027	Walker A/P-loop; other site
101510002028	ATP binding site [chemical binding]; other site
101510002029	Q-loop/lid; other site
101510002030	ABC transporter signature motif; other site
101510002031	Walker B; other site
101510002032	D-loop; other site
101510002033	H-loop/switch region; other site
101510002034	ABC-2 type transporter; Region: ABC2_membrane; cl11417
101510002035	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510002036	Helix-turn-helix domains; Region: HTH; cl00088
101510002037	Trm112p-like protein; Region: Trm112p; cl01066
101510002038	acyl-CoA synthetase; Validated; Region: PRK07868
101510002039	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510002040	argininosuccinate lyase; Provisional; Region: PRK00855
101510002041	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
101510002042	active sites [active]
101510002043	tetramer interface [polypeptide binding]; other site
101510002044	Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137
101510002045	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
101510002046	ANP binding site [chemical binding]; other site
101510002047	Substrate Binding Site II [chemical binding]; other site
101510002048	Substrate Binding Site I [chemical binding]; other site
101510002049	arginine repressor; Region: argR_whole; TIGR01529
101510002050	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
101510002051	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
101510002052	ornithine carbamoyltransferase; Provisional; Region: PRK00779
101510002053	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
101510002054	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510002055	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
101510002056	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
101510002057	inhibitor-cofactor binding pocket; inhibition site
101510002058	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510002059	catalytic residue [active]
101510002060	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
101510002061	feedback inhibition sensing region; other site
101510002062	homohexameric interface [polypeptide binding]; other site
101510002063	nucleotide binding site [chemical binding]; other site
101510002064	N-acetyl-L-glutamate binding site [chemical binding]; other site
101510002065	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
101510002066	heterotetramer interface [polypeptide binding]; other site
101510002067	active site pocket [active]
101510002068	cleavage site
101510002069	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
101510002070	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510002071	Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774
101510002072	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
101510002073	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
101510002074	putative tRNA-binding site [nucleotide binding]; other site
101510002075	B3/4 domain; Region: B3_4; cl11458
101510002076	tRNA synthetase B5 domain; Region: B5; cl08394
101510002077	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
101510002078	dimer interface [polypeptide binding]; other site
101510002079	motif 1; other site
101510002080	motif 3; other site
101510002081	motif 2; other site
101510002082	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
101510002083	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
101510002084	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
101510002085	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
101510002086	dimer interface [polypeptide binding]; other site
101510002087	motif 1; other site
101510002088	active site
101510002089	motif 2; other site
101510002090	motif 3; other site
101510002091	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
101510002092	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
101510002093	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
101510002094	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
101510002095	23S rRNA binding site [nucleotide binding]; other site
101510002096	L21 binding site [polypeptide binding]; other site
101510002097	L13 binding site [polypeptide binding]; other site
101510002098	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
101510002099	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
101510002100	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
101510002101	Protein of unknown function (DUF419); Region: DUF419; cl15265
101510002102	Predicted transcriptional regulator [Transcription]; Region: COG2378
101510002103	Helix-turn-helix domains; Region: HTH; cl00088
101510002104	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510002105	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510002106	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
101510002107	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
101510002108	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
101510002109	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
101510002110	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510002111	DoxX; Region: DoxX; cl00976
101510002112	DoxX; Region: DoxX; cl00976
101510002113	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
101510002114	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510002115	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510002116	Protein of unknown function (DUF732); Region: DUF732; pfam05305
101510002117	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
101510002118	excinuclease ABC subunit B; Provisional; Region: PRK05298
101510002119	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510002120	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
101510002121	nucleotide binding region [chemical binding]; other site
101510002122	ATP-binding site [chemical binding]; other site
101510002123	Ultra-violet resistance protein B; Region: UvrB; pfam12344
101510002124	UvrB/uvrC motif; Region: UVR; pfam02151
101510002125	Protein of unknown function (DUF402); Region: DUF402; cl00979
101510002126	dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333
101510002127	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
101510002128	CoA-binding site [chemical binding]; other site
101510002129	ATP-binding [chemical binding]; other site
101510002130	Uncharacterised protein family (UPF0157); Region: UPF0157; cl00987
101510002131	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
101510002132	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
101510002133	RNA binding site [nucleotide binding]; other site
101510002134	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
101510002135	RNA binding site [nucleotide binding]; other site
101510002136	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
101510002137	RNA binding site [nucleotide binding]; other site
101510002138	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
101510002139	RNA binding site [nucleotide binding]; other site
101510002140	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510002141	S-adenosylmethionine binding site [chemical binding]; other site
101510002142	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
101510002143	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
101510002144	Walker A/P-loop; other site
101510002145	ATP binding site [chemical binding]; other site
101510002146	Q-loop/lid; other site
101510002147	ABC transporter signature motif; other site
101510002148	Walker B; other site
101510002149	D-loop; other site
101510002150	H-loop/switch region; other site
101510002151	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
101510002152	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510002153	dimer interface [polypeptide binding]; other site
101510002154	conserved gate region; other site
101510002155	putative PBP binding loops; other site
101510002156	ABC-ATPase subunit interface; other site
101510002157	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
101510002158	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
101510002159	substrate binding pocket [chemical binding]; other site
101510002160	membrane-bound complex binding site; other site
101510002161	hinge residues; other site
101510002162	tartrate dehydrogenase; Provisional; Region: PRK08194
101510002163	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
101510002164	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
101510002165	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
101510002166	EamA-like transporter family; Region: EamA; cl01037
101510002167	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
101510002168	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
101510002169	conserved cys residue [active]
101510002170	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510002171	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
101510002172	catalytic residues [active]
101510002173	DNA polymerase I; Region: pola; TIGR00593
101510002174	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
101510002175	active site
101510002176	metal binding site 1 [ion binding]; metal-binding site
101510002177	putative 5' ssDNA interaction site; other site
101510002178	metal binding site 3; metal-binding site
101510002179	metal binding site 2 [ion binding]; metal-binding site
101510002180	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
101510002181	putative DNA binding site [nucleotide binding]; other site
101510002182	putative metal binding site [ion binding]; other site
101510002183	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
101510002184	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
101510002185	active site
101510002186	DNA binding site [nucleotide binding]
101510002187	catalytic site [active]
101510002188	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
101510002189	TM-ABC transporter signature motif; other site
101510002190	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
101510002191	TM-ABC transporter signature motif; other site
101510002192	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
101510002193	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
101510002194	Walker A/P-loop; other site
101510002195	ATP binding site [chemical binding]; other site
101510002196	Q-loop/lid; other site
101510002197	ABC transporter signature motif; other site
101510002198	Walker B; other site
101510002199	D-loop; other site
101510002200	H-loop/switch region; other site
101510002201	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
101510002202	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
101510002203	Walker A/P-loop; other site
101510002204	ATP binding site [chemical binding]; other site
101510002205	Q-loop/lid; other site
101510002206	ABC transporter signature motif; other site
101510002207	Walker B; other site
101510002208	D-loop; other site
101510002209	H-loop/switch region; other site
101510002210	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
101510002211	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
101510002212	Helix-turn-helix domains; Region: HTH; cl00088
101510002213	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
101510002214	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
101510002215	NADP binding site [chemical binding]; other site
101510002216	active site
101510002217	steroid binding site; other site
101510002218	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
101510002219	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510002220	active site
101510002221	phosphorylation site [posttranslational modification]
101510002222	intermolecular recognition site; other site
101510002223	dimerization interface [polypeptide binding]; other site
101510002224	ANTAR domain; Region: ANTAR; cl04297
101510002225	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
101510002226	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
101510002227	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
101510002228	putative hydrophobic ligand binding site [chemical binding]; other site
101510002229	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
101510002230	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
101510002231	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
101510002232	Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome.  The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223
101510002233	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
101510002234	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
101510002235	active site
101510002236	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
101510002237	catalytic triad [active]
101510002238	dimer interface [polypeptide binding]; other site
101510002239	pyruvate kinase; Provisional; Region: PRK06247
101510002240	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
101510002241	domain interfaces; other site
101510002242	active site
101510002243	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
101510002244	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510002245	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
101510002246	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
101510002247	active site
101510002248	dimer interface [polypeptide binding]; other site
101510002249	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
101510002250	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
101510002251	active site
101510002252	FMN binding site [chemical binding]; other site
101510002253	substrate binding site [chemical binding]; other site
101510002254	3Fe-4S cluster binding site [ion binding]; other site
101510002255	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
101510002256	domain interface; other site
101510002257	TM2 domain; Region: TM2; cl00984
101510002258	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
101510002259	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
101510002260	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
101510002261	substrate binding site [chemical binding]; other site
101510002262	active site
101510002263	catalytic residues [active]
101510002264	heterodimer interface [polypeptide binding]; other site
101510002265	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
101510002266	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
101510002267	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510002268	catalytic residue [active]
101510002269	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
101510002270	active site
101510002271	ribulose/triose binding site [chemical binding]; other site
101510002272	phosphate binding site [ion binding]; other site
101510002273	substrate (anthranilate) binding pocket [chemical binding]; other site
101510002274	product (indole) binding pocket [chemical binding]; other site
101510002275	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl09759
101510002276	anthranilate synthase component I; Provisional; Region: PRK13571
101510002277	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
101510002278	chorismate binding enzyme; Region: Chorismate_bind; cl10555
101510002279	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
101510002280	catalytic triad [active]
101510002281	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
101510002282	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
101510002283	putative active site [active]
101510002284	metal binding site [ion binding]; metal-binding site
101510002285	Helix-turn-helix domains; Region: HTH; cl00088
101510002286	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
101510002287	active site 1 [active]
101510002288	dimer interface [polypeptide binding]; other site
101510002289	hexamer interface [polypeptide binding]; other site
101510002290	active site 2 [active]
101510002291	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
101510002292	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
101510002293	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
101510002294	substrate binding site [chemical binding]; other site
101510002295	glutamase interaction surface [polypeptide binding]; other site
101510002296	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
101510002297	active site
101510002298	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106
101510002299	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
101510002300	catalytic residues [active]
101510002301	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
101510002302	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
101510002303	putative active site [active]
101510002304	oxyanion strand; other site
101510002305	catalytic triad [active]
101510002306	Major Facilitator Superfamily; Region: MFS_1; pfam07690
101510002307	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
101510002308	putative active site pocket [active]
101510002309	4-fold oligomerization interface [polypeptide binding]; other site
101510002310	metal binding residues [ion binding]; metal-binding site
101510002311	3-fold/trimer interface [polypeptide binding]; other site
101510002312	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
101510002313	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
101510002314	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510002315	homodimer interface [polypeptide binding]; other site
101510002316	catalytic residue [active]
101510002317	Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815
101510002318	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
101510002319	NAD binding site [chemical binding]; other site
101510002320	dimerization interface [polypeptide binding]; other site
101510002321	product binding site; other site
101510002322	substrate binding site [chemical binding]; other site
101510002323	zinc binding site [ion binding]; other site
101510002324	catalytic residues [active]
101510002325	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; cl09206
101510002326	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510002327	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510002328	active site
101510002329	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
101510002330	LysE type translocator; Region: LysE; cl00565
101510002331	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896
101510002332	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
101510002333	dimerization interface [polypeptide binding]; other site
101510002334	active site
101510002335	L-aspartate oxidase; Provisional; Region: PRK07804
101510002336	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510002337	domain; Region: Succ_DH_flav_C; pfam02910
101510002338	Quinolinate synthetase A protein; Region: NadA; cl00420
101510002339	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
101510002340	nudix motif; other site
101510002341	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
101510002342	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510002343	Helix-turn-helix domains; Region: HTH; cl00088
101510002344	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
101510002345	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510002346	NAD(P) binding site [chemical binding]; other site
101510002347	active site
101510002348	Protein of unknown function (DUF2567); Region: DUF2567; pfam10821
101510002349	biotin synthase; Validated; Region: PRK06256
101510002350	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
101510002351	FeS/SAM binding site; other site
101510002352	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
101510002353	tetracycline repressor protein TetR; Provisional; Region: PRK13756
101510002354	Helix-turn-helix domains; Region: HTH; cl00088
101510002355	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
101510002356	Secretory lipase; Region: LIP; pfam03583
101510002357	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510002358	DNA-binding site [nucleotide binding]; DNA binding site
101510002359	FCD domain; Region: FCD; cl11656
101510002360	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
101510002361	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386
101510002362	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
101510002363	catalytic loop [active]
101510002364	iron binding site [ion binding]; other site
101510002365	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803
101510002366	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510002367	domain; Region: Succ_DH_flav_C; pfam02910
101510002368	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
101510002369	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510002370	active site
101510002371	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510002372	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
101510002373	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
101510002374	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
101510002375	catalytic residue [active]
101510002376	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
101510002377	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
101510002378	inhibitor-cofactor binding pocket; inhibition site
101510002379	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510002380	catalytic residue [active]
101510002381	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
101510002382	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
101510002383	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
101510002384	active site
101510002385	catalytic site [active]
101510002386	malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401
101510002387	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
101510002388	active site
101510002389	catalytic site [active]
101510002390	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
101510002391	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
101510002392	putative NAD(P) binding site [chemical binding]; other site
101510002393	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510002394	Helix-turn-helix domains; Region: HTH; cl00088
101510002395	Domain of unknown function (DUF1918); Region: DUF1918; pfam08940
101510002396	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
101510002397	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
101510002398	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
101510002399	catalytic site [active]
101510002400	active site
101510002401	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
101510002402	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
101510002403	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510002404	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510002405	Helix-turn-helix domains; Region: HTH; cl00088
101510002406	threonine dehydratase; Validated; Region: PRK08639
101510002407	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
101510002408	tetramer interface [polypeptide binding]; other site
101510002409	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510002410	catalytic residue [active]
101510002411	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
101510002412	pyruvate dehydrogenase; Provisional; Region: PRK06546
101510002413	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
101510002414	PYR/PP interface [polypeptide binding]; other site
101510002415	tetramer interface [polypeptide binding]; other site
101510002416	dimer interface [polypeptide binding]; other site
101510002417	TPP binding site [chemical binding]; other site
101510002418	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
101510002419	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
101510002420	TPP-binding site [chemical binding]; other site
101510002421	Domain of unknown function (DUF385); Region: DUF385; cl04387
101510002422	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
101510002423	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
101510002424	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
101510002425	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
101510002426	generic binding surface II; other site
101510002427	generic binding surface I; other site
101510002428	Predicted permeases [General function prediction only]; Region: RarD; COG2962
101510002429	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
101510002430	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
101510002431	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
101510002432	active site
101510002433	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
101510002434	lipoprotein signal peptidase; Provisional; Region: PRK14787
101510002435	PknH-like extracellular domain; Region: PknH_C; pfam14032
101510002436	DNA polymerase IV; Provisional; Region: PRK03348
101510002437	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
101510002438	active site
101510002439	DNA binding site [nucleotide binding]
101510002440	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
101510002441	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
101510002442	HIGH motif; other site
101510002443	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
101510002444	active site
101510002445	KMSKS motif; other site
101510002446	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
101510002447	tRNA binding surface [nucleotide binding]; other site
101510002448	anticodon binding site; other site
101510002449	DivIVA domain; Region: DivI1A_domain; TIGR03544
101510002450	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
101510002451	Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975
101510002452	YGGT family; Region: YGGT; cl00508
101510002453	Protein of unknown function (DUF552); Region: DUF552; cl00775
101510002454	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
101510002455	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
101510002456	catalytic residue [active]
101510002457	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
101510002458	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
101510002459	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
101510002460	nucleotide binding site [chemical binding]; other site
101510002461	SulA interaction site; other site
101510002462	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
101510002463	Cell division protein FtsQ; Region: FtsQ; pfam03799
101510002464	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
101510002465	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
101510002466	Mur ligase middle domain; Region: Mur_ligase_M; cl15713
101510002467	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
101510002468	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
101510002469	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
101510002470	active site
101510002471	homodimer interface [polypeptide binding]; other site
101510002472	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
101510002473	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369
101510002474	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510002475	Mur ligase middle domain; Region: Mur_ligase_M; cl15713
101510002476	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
101510002477	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
101510002478	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
101510002479	Mg++ binding site [ion binding]; other site
101510002480	putative catalytic motif [active]
101510002481	putative substrate binding site [chemical binding]; other site
101510002482	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
101510002483	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
101510002484	Mur ligase middle domain; Region: Mur_ligase_M; cl15713
101510002485	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
101510002486	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
101510002487	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
101510002488	Mur ligase middle domain; Region: Mur_ligase_M; cl15713
101510002489	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
101510002490	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
101510002491	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
101510002492	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
101510002493	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
101510002494	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510002495	cell division protein MraZ; Reviewed; Region: PRK00326
101510002496	MraZ protein; Region: MraZ; pfam02381
101510002497	MraZ protein; Region: MraZ; pfam02381
101510002498	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
101510002499	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
101510002500	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510002501	Protein of unknown function (DUF422); Region: DUF422; cl00991
101510002502	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
101510002503	active site
101510002504	Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219
101510002505	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
101510002506	FAD binding site [chemical binding]; other site
101510002507	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
101510002508	substrate binding pocket [chemical binding]; other site
101510002509	chain length determination region; other site
101510002510	substrate-Mg2+ binding site; other site
101510002511	catalytic residues [active]
101510002512	aspartate-rich region 1; other site
101510002513	active site lid residues [active]
101510002514	aspartate-rich region 2; other site
101510002515	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510002516	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
101510002517	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
101510002518	active site lid residues [active]
101510002519	substrate binding pocket [chemical binding]; other site
101510002520	catalytic residues [active]
101510002521	substrate-Mg2+ binding site; other site
101510002522	aspartate-rich region 1; other site
101510002523	aspartate-rich region 2; other site
101510002524	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510002525	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510002526	active site
101510002527	ATP binding site [chemical binding]; other site
101510002528	substrate binding site [chemical binding]; other site
101510002529	activation loop (A-loop); other site
101510002530	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
101510002531	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
101510002532	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
101510002533	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
101510002534	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
101510002535	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
101510002536	Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230
101510002537	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
101510002538	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
101510002539	putative acyl-acceptor binding pocket; other site
101510002540	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
101510002541	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
101510002542	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
101510002543	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
101510002544	DTAP/Switch II; other site
101510002545	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
101510002546	putative hydrophobic ligand binding site [chemical binding]; other site
101510002547	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510002548	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
101510002549	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510002550	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
101510002551	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
101510002552	NlpC/P60 family; Region: NLPC_P60; cl11438
101510002553	NlpC/P60 family; Region: NLPC_P60; cl11438
101510002554	hypothetical protein; Validated; Region: PRK07883
101510002555	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
101510002556	active site
101510002557	substrate binding site [chemical binding]; other site
101510002558	catalytic site [active]
101510002559	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
101510002560	GIY-YIG motif/motif A; other site
101510002561	active site
101510002562	catalytic site [active]
101510002563	putative DNA binding site [nucleotide binding]; other site
101510002564	metal binding site [ion binding]; metal-binding site
101510002565	Helix-turn-helix domains; Region: HTH; cl00088
101510002566	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
101510002567	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
101510002568	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
101510002569	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
101510002570	Subunit I/III interface [polypeptide binding]; other site
101510002571	Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857
101510002572	Cytochrome c; Region: Cytochrom_C; cl11414
101510002573	Cytochrome c; Region: Cytochrom_C; cl11414
101510002574	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
101510002575	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
101510002576	iron-sulfur cluster [ion binding]; other site
101510002577	[2Fe-2S] cluster binding site [ion binding]; other site
101510002578	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
101510002579	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
101510002580	heme bH binding site [chemical binding]; other site
101510002581	intrachain domain interface; other site
101510002582	heme bL binding site [chemical binding]; other site
101510002583	interchain domain interface [polypeptide binding]; other site
101510002584	Qo binding site; other site
101510002585	EamA-like transporter family; Region: EamA; cl01037
101510002586	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510002587	Helix-turn-helix domains; Region: HTH; cl00088
101510002588	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
101510002589	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
101510002590	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
101510002591	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
101510002592	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
101510002593	dimer interface [polypeptide binding]; other site
101510002594	active site
101510002595	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
101510002596	Ligand Binding Site [chemical binding]; other site
101510002597	Molecular Tunnel; other site
101510002598	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
101510002599	substrate binding site [chemical binding]; other site
101510002600	ATP binding site [chemical binding]; other site
101510002601	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
101510002602	Glycerate kinase family; Region: Gly_kinase; cl00841
101510002603	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
101510002604	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
101510002605	homotrimer interface [polypeptide binding]; other site
101510002606	Walker A motif; other site
101510002607	GTP binding site [chemical binding]; other site
101510002608	Walker B motif; other site
101510002609	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
101510002610	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
101510002611	putative dimer interface [polypeptide binding]; other site
101510002612	active site pocket [active]
101510002613	putative cataytic base [active]
101510002614	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
101510002615	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
101510002616	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
101510002617	homodimer interface [polypeptide binding]; other site
101510002618	substrate-cofactor binding pocket; other site
101510002619	catalytic residue [active]
101510002620	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
101510002621	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
101510002622	multifunctional aminopeptidase A; Provisional; Region: PRK00913
101510002623	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
101510002624	interface (dimer of trimers) [polypeptide binding]; other site
101510002625	Substrate-binding/catalytic site; other site
101510002626	Zn-binding sites [ion binding]; other site
101510002627	2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927
101510002628	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
101510002629	E3 interaction surface; other site
101510002630	lipoyl attachment site [posttranslational modification]; other site
101510002631	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
101510002632	E3 interaction surface; other site
101510002633	lipoyl attachment site [posttranslational modification]; other site
101510002634	e3 binding domain; Region: E3_binding; pfam02817
101510002635	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
101510002636	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
101510002637	TIGR01777 family protein; Region: yfcH
101510002638	putative NAD(P) binding site [chemical binding]; other site
101510002639	putative active site [active]
101510002640	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
101510002641	lipoyl synthase; Provisional; Region: PRK05481
101510002642	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
101510002643	FeS/SAM binding site; other site
101510002644	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
101510002645	RDD family; Region: RDD; cl00746
101510002646	glutamine synthetase, type I; Region: GlnA; TIGR00653
101510002647	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
101510002648	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
101510002649	A new structural DNA glycosylase; Region: AlkD_like; cd06561
101510002650	active site
101510002651	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
101510002652	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510002653	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
101510002654	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
101510002655	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
101510002656	OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment.  ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295
101510002657	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
101510002658	Walker A/P-loop; other site
101510002659	ATP binding site [chemical binding]; other site
101510002660	Q-loop/lid; other site
101510002661	ABC transporter signature motif; other site
101510002662	Walker B; other site
101510002663	D-loop; other site
101510002664	H-loop/switch region; other site
101510002665	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510002666	dimer interface [polypeptide binding]; other site
101510002667	conserved gate region; other site
101510002668	putative PBP binding loops; other site
101510002669	ABC-ATPase subunit interface; other site
101510002670	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
101510002671	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
101510002672	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
101510002673	putative catalytic site [active]
101510002674	putative metal binding site [ion binding]; other site
101510002675	putative phosphate binding site [ion binding]; other site
101510002676	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
101510002677	putative catalytic site [active]
101510002678	putative phosphate binding site [ion binding]; other site
101510002679	putative metal binding site [ion binding]; other site
101510002680	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
101510002681	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
101510002682	metal binding triad; other site
101510002683	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
101510002684	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
101510002685	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
101510002686	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
101510002687	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
101510002688	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
101510002689	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
101510002690	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510002691	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
101510002692	oligomerization interface [polypeptide binding]; other site
101510002693	active site
101510002694	metal binding site [ion binding]; metal-binding site
101510002695	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
101510002696	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510002697	RNB domain; Region: RNB; pfam00773
101510002698	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
101510002699	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
101510002700	active site
101510002701	catalytic site [active]
101510002702	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
101510002703	active site 2 [active]
101510002704	active site 1 [active]
101510002705	LysE type translocator; Region: LysE; cl00565
101510002706	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510002707	Protein of unknown function (DUF1697); Region: DUF1697; cl01557
101510002708	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
101510002709	transmembrane helices; other site
101510002710	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
101510002711	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
101510002712	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
101510002713	RNA/DNA hybrid binding site [nucleotide binding]; other site
101510002714	active site
101510002715	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
101510002716	catalytic core [active]
101510002717	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
101510002718	Putative zinc ribbon domain; Region: DUF164; pfam02591
101510002719	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
101510002720	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
101510002721	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
101510002722	hypothetical protein; Provisional; Region: PRK07908
101510002723	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
101510002724	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510002725	homodimer interface [polypeptide binding]; other site
101510002726	catalytic residue [active]
101510002727	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
101510002728	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
101510002729	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
101510002730	motif II; other site
101510002731	Low molecular weight phosphatase family; Region: LMWPc; cd00115
101510002732	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
101510002733	active site
101510002734	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
101510002735	CobD/Cbib protein; Region: CobD_Cbib; cl00561
101510002736	Predicted transcriptional regulators [Transcription]; Region: COG1510
101510002737	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
101510002738	dimer interface [polypeptide binding]; other site
101510002739	catalytic triad [active]
101510002740	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
101510002741	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
101510002742	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
101510002743	dimer interface [polypeptide binding]; other site
101510002744	TPP-binding site [chemical binding]; other site
101510002745	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
101510002746	Acyl transferase domain; Region: Acyl_transf_1; cl08282
101510002747	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
101510002748	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510002749	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
101510002750	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
101510002751	dimer interface [polypeptide binding]; other site
101510002752	active site
101510002753	Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039
101510002754	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780
101510002755	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780
101510002756	Protein of unknown function (DUF3145); Region: DUF3145; pfam11343
101510002757	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
101510002758	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
101510002759	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
101510002760	NAD binding site [chemical binding]; other site
101510002761	catalytic Zn binding site [ion binding]; other site
101510002762	substrate binding site [chemical binding]; other site
101510002763	structural Zn binding site [ion binding]; other site
101510002764	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510002765	Adenosine specific kinase; Region: Adenosine_kin; cl00796
101510002766	Domain of unknown function DUF20; Region: UPF0118; cl00465
101510002767	DNA primase; Validated; Region: dnaG; PRK05667
101510002768	CHC2 zinc finger; Region: zf-CHC2; cl15369
101510002769	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
101510002770	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
101510002771	active site
101510002772	metal binding site [ion binding]; metal-binding site
101510002773	interdomain interaction site; other site
101510002774	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
101510002775	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879
101510002776	Secretory lipase; Region: LIP; pfam03583
101510002777	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
101510002778	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
101510002779	putative active site [active]
101510002780	Domain of unknown function (DUF477); Region: DUF477; cl01535
101510002781	glycyl-tRNA synthetase; Provisional; Region: PRK04173
101510002782	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
101510002783	motif 1; other site
101510002784	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774
101510002785	active site
101510002786	motif 2; other site
101510002787	motif 3; other site
101510002788	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
101510002789	anticodon binding site; other site
101510002790	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
101510002791	dimerization interface [polypeptide binding]; other site
101510002792	putative DNA binding site [nucleotide binding]; other site
101510002793	putative Zn2+ binding site [ion binding]; other site
101510002794	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
101510002795	metal binding site 2 [ion binding]; metal-binding site
101510002796	putative DNA binding helix; other site
101510002797	metal binding site 1 [ion binding]; metal-binding site
101510002798	dimer interface [polypeptide binding]; other site
101510002799	structural Zn2+ binding site [ion binding]; other site
101510002800	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
101510002801	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
101510002802	catalytic residue [active]
101510002803	putative FPP diphosphate  binding site; other site
101510002804	putative FPP binding hydrophobic cleft; other site
101510002805	dimer interface [polypeptide binding]; other site
101510002806	putative IPP diphosphate binding site; other site
101510002807	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
101510002808	Recombination protein O N terminal; Region: RecO_N; pfam11967
101510002809	Recombination protein O C terminal; Region: RecO_C; pfam02565
101510002810	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510002811	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510002812	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
101510002813	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
101510002814	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510002815	active site
101510002816	phosphorylation site [posttranslational modification]
101510002817	intermolecular recognition site; other site
101510002818	dimerization interface [polypeptide binding]; other site
101510002819	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
101510002820	DNA binding site [nucleotide binding]
101510002821	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
101510002822	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
101510002823	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
101510002824	Ligand Binding Site [chemical binding]; other site
101510002825	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
101510002826	dimer interface [polypeptide binding]; other site
101510002827	phosphorylation site [posttranslational modification]
101510002828	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510002829	ATP binding site [chemical binding]; other site
101510002830	Mg2+ binding site [ion binding]; other site
101510002831	G-X-G motif; other site
101510002832	K+-transporting ATPase, c chain; Region: KdpC; cl00944
101510002833	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
101510002834	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
101510002835	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
101510002836	Potassium-transporting ATPase A subunit; Region: KdpA; cl00903
101510002837	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
101510002838	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
101510002839	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510002840	DNA-binding site [nucleotide binding]; DNA binding site
101510002841	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
101510002842	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510002843	homodimer interface [polypeptide binding]; other site
101510002844	catalytic residue [active]
101510002845	amidase; Provisional; Region: PRK06061
101510002846	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
101510002847	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510002848	Helix-turn-helix domains; Region: HTH; cl00088
101510002849	GTPase Era; Reviewed; Region: era; PRK00089
101510002850	Era subfamily.  Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria.  It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit, possibly...; Region: Era; cd04163
101510002851	G1 box; other site
101510002852	GTP/Mg2+ binding site [chemical binding]; other site
101510002853	Switch I region; other site
101510002854	G2 box; other site
101510002855	Switch II region; other site
101510002856	G3 box; other site
101510002857	G4 box; other site
101510002858	G5 box; other site
101510002859	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
101510002860	Domain of unknown function DUF21; Region: DUF21; pfam01595
101510002861	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
101510002862	Transporter associated domain; Region: CorC_HlyC; cl08393
101510002863	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
101510002864	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
101510002865	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
101510002866	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510002867	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
101510002868	metal binding site [ion binding]; metal-binding site
101510002869	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
101510002870	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510002871	RNA methyltransferase; Region: Methyltrans_RNA; cl00611
101510002872	RNA methyltransferase, RsmE family; Region: TIGR00046
101510002873	chaperone protein DnaJ; Provisional; Region: PRK14278
101510002874	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
101510002875	HSP70 interaction site [polypeptide binding]; other site
101510002876	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
101510002877	Zn binding sites [ion binding]; other site
101510002878	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
101510002879	dimer interface [polypeptide binding]; other site
101510002880	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
101510002881	HrcA protein C terminal domain; Region: HrcA; pfam01628
101510002882	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270
101510002883	coproporphyrinogen III oxidase; Validated; Region: PRK05628
101510002884	HemN C-terminal region; Region: HemN_C; pfam06969
101510002885	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
101510002886	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
101510002887	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
101510002888	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
101510002889	Active Sites [active]
101510002890	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
101510002891	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
101510002892	Active Sites [active]
101510002893	sulfate adenylyltransferase, large subunit; Region: CysN; TIGR02034
101510002894	CysN_ATPS subfamily.  CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes.  ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate.  CysD, which...; Region: CysN_ATPS; cd04166
101510002895	CysD dimerization site [polypeptide binding]; other site
101510002896	G1 box; other site
101510002897	putative GEF interaction site [polypeptide binding]; other site
101510002898	GTP/Mg2+ binding site [chemical binding]; other site
101510002899	Switch I region; other site
101510002900	G2 box; other site
101510002901	G3 box; other site
101510002902	Switch II region; other site
101510002903	G4 box; other site
101510002904	G5 box; other site
101510002905	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
101510002906	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
101510002907	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
101510002908	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
101510002909	putative active site [active]
101510002910	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
101510002911	putative active site [active]
101510002912	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
101510002913	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
101510002914	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510002915	homodimer interface [polypeptide binding]; other site
101510002916	catalytic residue [active]
101510002917	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
101510002918	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
101510002919	active site
101510002920	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
101510002921	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
101510002922	PYR/PP interface [polypeptide binding]; other site
101510002923	dimer interface [polypeptide binding]; other site
101510002924	TPP binding site [chemical binding]; other site
101510002925	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
101510002926	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
101510002927	TPP-binding site [chemical binding]; other site
101510002928	Putative zinc-finger; Region: zf-HC2; cl15806
101510002929	RNA polymerase sigma factor SigL; Provisional; Region: PRK09645
101510002930	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
101510002931	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
101510002932	DNA binding residues [nucleotide binding]
101510002933	Protein of unknown function (DUF419); Region: DUF419; cl15265
101510002934	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
101510002935	Ligand Binding Site [chemical binding]; other site
101510002936	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
101510002937	Ligand Binding Site [chemical binding]; other site
101510002938	Stf0 sulphotransferase; Region: Sulphotransf; cl01835
101510002939	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
101510002940	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
101510002941	Active Sites [active]
101510002942	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
101510002943	CysN_ATPS subfamily.  CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes.  ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate.  CysD, which...; Region: CysN_ATPS; cd04166
101510002944	CysD dimerization site [polypeptide binding]; other site
101510002945	G1 box; other site
101510002946	putative GEF interaction site [polypeptide binding]; other site
101510002947	GTP/Mg2+ binding site [chemical binding]; other site
101510002948	Switch I region; other site
101510002949	G2 box; other site
101510002950	G3 box; other site
101510002951	Switch II region; other site
101510002952	G4 box; other site
101510002953	G5 box; other site
101510002954	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
101510002955	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
101510002956	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027
101510002957	ligand-binding site [chemical binding]; other site
101510002958	Mur ligase middle domain; Region: Mur_ligase_M; cl15713
101510002959	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
101510002960	Sulfatase; Region: Sulfatase; cl10460
101510002961	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
101510002962	Part of the ABC transporter complex cysAWTP involved in sulfate import.  Responsible for energy coupling to the transport system.  The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296
101510002963	Walker A/P-loop; other site
101510002964	ATP binding site [chemical binding]; other site
101510002965	Q-loop/lid; other site
101510002966	ABC transporter signature motif; other site
101510002967	Walker B; other site
101510002968	D-loop; other site
101510002969	H-loop/switch region; other site
101510002970	TOBE domain; Region: TOBE_2; cl01440
101510002971	sulfate transport protein; Provisional; Region: cysT; CHL00187
101510002972	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510002973	dimer interface [polypeptide binding]; other site
101510002974	conserved gate region; other site
101510002975	putative PBP binding loops; other site
101510002976	ABC-ATPase subunit interface; other site
101510002977	sulfate transport protein; Provisional; Region: cysT; CHL00187
101510002978	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510002979	dimer interface [polypeptide binding]; other site
101510002980	conserved gate region; other site
101510002981	putative PBP binding loops; other site
101510002982	ABC-ATPase subunit interface; other site
101510002983	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
101510002984	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
101510002985	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
101510002986	Nitronate monooxygenase; Region: NMO; pfam03060
101510002987	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
101510002988	FMN binding site [chemical binding]; other site
101510002989	substrate binding site [chemical binding]; other site
101510002990	putative catalytic residue [active]
101510002991	GTP-binding protein LepA; Provisional; Region: PRK05433
101510002992	LepA subfamily.  LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome.  LepA is ubiquitous in bacteria and...; Region: LepA; cd01890
101510002993	G1 box; other site
101510002994	putative GEF interaction site [polypeptide binding]; other site
101510002995	GTP/Mg2+ binding site [chemical binding]; other site
101510002996	Switch I region; other site
101510002997	G2 box; other site
101510002998	G3 box; other site
101510002999	Switch II region; other site
101510003000	G4 box; other site
101510003001	G5 box; other site
101510003002	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
101510003003	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
101510003004	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
101510003005	PemK-like protein; Region: PemK; cl00995
101510003006	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
101510003007	active site
101510003008	catalytic triad [active]
101510003009	oxyanion hole [active]
101510003010	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
101510003011	amphipathic channel; other site
101510003012	Asn-Pro-Ala signature motifs; other site
101510003013	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
101510003014	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
101510003015	Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980
101510003016	Uncharacterized conserved protein [Function unknown]; Region: COG2308
101510003017	Domain of unknown function (DUF404); Region: DUF404; pfam04169
101510003018	Domain of unknown function (DUF407); Region: DUF407; pfam04174
101510003019	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
101510003020	hypothetical protein; Reviewed; Region: PRK07914
101510003021	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
101510003022	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
101510003023	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
101510003024	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510003025	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
101510003026	substrate binding pocket [chemical binding]; other site
101510003027	catalytic triad [active]
101510003028	ANTAR domain; Region: ANTAR; cl04297
101510003029	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
101510003030	F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557
101510003031	Competence protein; Region: Competence; cl00471
101510003032	SLBB domain; Region: SLBB; pfam10531
101510003033	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
101510003034	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
101510003035	Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577
101510003036	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
101510003037	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
101510003038	Domain of unknown function DUF143; Region: DUF143; cl00519
101510003039	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
101510003040	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
101510003041	active site
101510003042	(T/H)XGH motif; other site
101510003043	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
101510003044	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
101510003045	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
101510003046	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
101510003047	Walker A motif; other site
101510003048	ATP binding site [chemical binding]; other site
101510003049	Walker B motif; other site
101510003050	arginine finger; other site
101510003051	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
101510003052	putative catalytic cysteine [active]
101510003053	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
101510003054	active site
101510003055	FMN binding site [chemical binding]; other site
101510003056	substrate binding site [chemical binding]; other site
101510003057	homotetramer interface [polypeptide binding]; other site
101510003058	catalytic residue [active]
101510003059	proline/glycine betaine transporter; Provisional; Region: PRK10642
101510003060	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510003061	putative substrate translocation pore; other site
101510003062	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
101510003063	substrate binding site [chemical binding]; other site
101510003064	ATP binding site [chemical binding]; other site
101510003065	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
101510003066	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
101510003067	ATP binding site [chemical binding]; other site
101510003068	putative Mg++ binding site [ion binding]; other site
101510003069	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
101510003070	nucleotide binding region [chemical binding]; other site
101510003071	ATP-binding site [chemical binding]; other site
101510003072	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
101510003073	Coenzyme A binding pocket [chemical binding]; other site
101510003074	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
101510003075	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
101510003076	inhibitor-cofactor binding pocket; inhibition site
101510003077	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510003078	catalytic residue [active]
101510003079	Cupin domain; Region: Cupin_2; cl09118
101510003080	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510003081	SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409
101510003082	NAD+ binding site [chemical binding]; other site
101510003083	substrate binding site [chemical binding]; other site
101510003084	Zn binding site [ion binding]; other site
101510003085	gamma-glutamyl kinase; Provisional; Region: PRK05429
101510003086	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
101510003087	nucleotide binding site [chemical binding]; other site
101510003088	homotetrameric interface [polypeptide binding]; other site
101510003089	putative phosphate binding site [ion binding]; other site
101510003090	putative allosteric binding site; other site
101510003091	PUA domain; Region: PUA; cl00607
101510003092	GTPase CgtA; Reviewed; Region: obgE; PRK12296
101510003093	GTP1/OBG; Region: GTP1_OBG; pfam01018
101510003094	Obg subfamily.  The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation.  Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898
101510003095	G1 box; other site
101510003096	GTP/Mg2+ binding site [chemical binding]; other site
101510003097	Switch I region; other site
101510003098	G2 box; other site
101510003099	G3 box; other site
101510003100	Switch II region; other site
101510003101	G4 box; other site
101510003102	G5 box; other site
101510003103	Domain of unknown function (DUF1967); Region: DUF1967; cl07779
101510003104	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
101510003105	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
101510003106	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
101510003107	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
101510003108	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
101510003109	homodimer interface [polypeptide binding]; other site
101510003110	oligonucleotide binding site [chemical binding]; other site
101510003111	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
101510003112	active site
101510003113	multimer interface [polypeptide binding]; other site
101510003114	Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
101510003115	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
101510003116	Mur ligase middle domain; Region: Mur_ligase_M; cl15713
101510003117	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
101510003118	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
101510003119	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
101510003120	HIGH motif; other site
101510003121	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
101510003122	active site
101510003123	KMSKS motif; other site
101510003124	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
101510003125	tRNA binding surface [nucleotide binding]; other site
101510003126	anticodon binding site; other site
101510003127	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
101510003128	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
101510003129	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
101510003130	Sodium:solute symporter family; Region: SSF; cl00456
101510003131	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
101510003132	homotrimer interaction site [polypeptide binding]; other site
101510003133	putative active site [active]
101510003134	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510003135	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898
101510003136	putative hydrophobic ligand binding site [chemical binding]; other site
101510003137	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
101510003138	active site
101510003139	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
101510003140	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510003141	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
101510003142	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
101510003143	siderophore binding site; other site
101510003144	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
101510003145	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
101510003146	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
101510003147	Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464
101510003148	multimer interface [polypeptide binding]; other site
101510003149	heterodimer interface [polypeptide binding]; other site
101510003150	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
101510003151	active site
101510003152	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
101510003153	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
101510003154	heterodimer interface [polypeptide binding]; other site
101510003155	active site
101510003156	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
101510003157	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
101510003158	tetramer interface [polypeptide binding]; other site
101510003159	active site
101510003160	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
101510003161	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
101510003162	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
101510003163	Helix-turn-helix domains; Region: HTH; cl00088
101510003164	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510003165	acetyl-CoA acetyltransferase; Provisional; Region: PRK06205
101510003166	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
101510003167	dimer interface [polypeptide binding]; other site
101510003168	active site
101510003169	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
101510003170	active site
101510003171	metal binding site [ion binding]; metal-binding site
101510003172	homotetramer interface [polypeptide binding]; other site
101510003173	shikimate 5-dehydrogenase; Reviewed; Region: PRK12549
101510003174	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
101510003175	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
101510003176	shikimate binding site; other site
101510003177	NAD(P) binding site [chemical binding]; other site
101510003178	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
101510003179	Helix-turn-helix domains; Region: HTH; cl00088
101510003180	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510003181	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510003182	putative substrate translocation pore; other site
101510003183	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
101510003184	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
101510003185	Walker A/P-loop; other site
101510003186	ATP binding site [chemical binding]; other site
101510003187	Q-loop/lid; other site
101510003188	ABC transporter signature motif; other site
101510003189	Walker B; other site
101510003190	D-loop; other site
101510003191	H-loop/switch region; other site
101510003192	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
101510003193	TM-ABC transporter signature motif; other site
101510003194	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
101510003195	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
101510003196	putative ligand binding site [chemical binding]; other site
101510003197	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510003198	putative transporter; Provisional; Region: PRK10504
101510003199	putative substrate translocation pore; other site
101510003200	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
101510003201	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510003202	DNA-binding site [nucleotide binding]; DNA binding site
101510003203	UTRA domain; Region: UTRA; cl01230
101510003204	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
101510003205	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
101510003206	substrate binding site [chemical binding]; other site
101510003207	ATP binding site [chemical binding]; other site
101510003208	KduI/IolB family; Region: KduI; cl01508
101510003209	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
101510003210	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
101510003211	PYR/PP interface [polypeptide binding]; other site
101510003212	dimer interface [polypeptide binding]; other site
101510003213	TPP binding site [chemical binding]; other site
101510003214	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
101510003215	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
101510003216	TPP-binding site; other site
101510003217	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
101510003218	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510003219	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
101510003220	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
101510003221	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
101510003222	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510003223	tetrameric interface [polypeptide binding]; other site
101510003224	NAD binding site [chemical binding]; other site
101510003225	catalytic residues [active]
101510003226	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
101510003227	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510003228	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
101510003229	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
101510003230	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
101510003231	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510003232	putative substrate translocation pore; other site
101510003233	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510003234	Transcriptional regulators [Transcription]; Region: PurR; COG1609
101510003235	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
101510003236	DNA binding site [nucleotide binding]
101510003237	domain linker motif; other site
101510003238	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
101510003239	dimerization interface [polypeptide binding]; other site
101510003240	ligand binding site [chemical binding]; other site
101510003241	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
101510003242	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184
101510003243	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
101510003244	DNA binding site [nucleotide binding]
101510003245	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
101510003246	putative ligand binding site [chemical binding]; other site
101510003247	Peptidase family M23; Region: Peptidase_M23; pfam01551
101510003248	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
101510003249	AP (apurinic/apyrimidinic) site pocket; other site
101510003250	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
101510003251	DNA interaction; other site
101510003252	Metal-binding active site; metal-binding site
101510003253	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
101510003254	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
101510003255	active site
101510003256	Fe binding site [ion binding]; other site
101510003257	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
101510003258	trimer interface [polypeptide binding]; other site
101510003259	active site
101510003260	dimer interface [polypeptide binding]; other site
101510003261	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
101510003262	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
101510003263	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
101510003264	Walker A motif; other site
101510003265	ATP binding site [chemical binding]; other site
101510003266	Walker B motif; other site
101510003267	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
101510003268	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
101510003269	oligomer interface [polypeptide binding]; other site
101510003270	active site residues [active]
101510003271	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
101510003272	oligomer interface [polypeptide binding]; other site
101510003273	active site residues [active]
101510003274	trigger factor; Provisional; Region: tig; PRK01490
101510003275	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
101510003276	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
101510003277	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
101510003278	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
101510003279	putative DNA binding site [nucleotide binding]; other site
101510003280	catalytic residue [active]
101510003281	putative H2TH interface [polypeptide binding]; other site
101510003282	putative catalytic residues [active]
101510003283	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
101510003284	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
101510003285	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
101510003286	Peptidase family M48; Region: Peptidase_M48; cl12018
101510003287	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
101510003288	catalytic residues [active]
101510003289	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
101510003290	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510003291	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
101510003292	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
101510003293	Zn binding site [ion binding]; other site
101510003294	Domain of unknown function (DUF3358); Region: DUF3358; pfam11838
101510003295	DNA polymerase IV; Validated; Region: PRK03858
101510003296	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
101510003297	active site
101510003298	DNA binding site [nucleotide binding]
101510003299	Helix-turn-helix domain; Region: HTH_18; pfam12833
101510003300	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510003301	Domain of unknown function (DUF477); Region: DUF477; cl01535
101510003302	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
101510003303	active site
101510003304	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
101510003305	apolar tunnel; other site
101510003306	heme binding site [chemical binding]; other site
101510003307	dimerization interface [polypeptide binding]; other site
101510003308	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
101510003309	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
101510003310	active site
101510003311	catalytic site [active]
101510003312	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
101510003313	active site
101510003314	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
101510003315	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
101510003316	active site
101510003317	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
101510003318	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510003319	Walker A/P-loop; other site
101510003320	ATP binding site [chemical binding]; other site
101510003321	Q-loop/lid; other site
101510003322	ABC transporter signature motif; other site
101510003323	Walker B; other site
101510003324	D-loop; other site
101510003325	H-loop/switch region; other site
101510003326	ABC transporter; Region: ABC_tran_2; pfam12848
101510003327	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
101510003328	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
101510003329	dimer interface [polypeptide binding]; other site
101510003330	ssDNA binding site [nucleotide binding]; other site
101510003331	tetramer (dimer of dimers) interface [polypeptide binding]; other site
101510003332	Copper resistance protein D; Region: CopD; cl00563
101510003333	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173
101510003334	Transposase; Region: DEDD_Tnp_IS110; pfam01548
101510003335	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
101510003336	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
101510003337	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510003338	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510003339	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
101510003340	CoenzymeA binding site [chemical binding]; other site
101510003341	subunit interaction site [polypeptide binding]; other site
101510003342	PHB binding site; other site
101510003343	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
101510003344	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510003345	NAD(P) binding site [chemical binding]; other site
101510003346	active site
101510003347	Helix-turn-helix domains; Region: HTH; cl00088
101510003348	glutamate dehydrogenase; Provisional; Region: PRK09414
101510003349	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
101510003350	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
101510003351	NAD(P) binding site [chemical binding]; other site
101510003352	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
101510003353	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
101510003354	putative di-iron ligands [ion binding]; other site
101510003355	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
101510003356	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
101510003357	FAD binding pocket [chemical binding]; other site
101510003358	FAD binding motif [chemical binding]; other site
101510003359	phosphate binding motif [ion binding]; other site
101510003360	beta-alpha-beta structure motif; other site
101510003361	NAD binding pocket [chemical binding]; other site
101510003362	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
101510003363	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
101510003364	Helix-turn-helix domains; Region: HTH; cl00088
101510003365	short chain dehydrogenase; Validated; Region: PRK05855
101510003366	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510003367	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
101510003368	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510003369	putative substrate translocation pore; other site
101510003370	Helix-turn-helix domains; Region: HTH; cl00088
101510003371	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
101510003372	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
101510003373	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
101510003374	active site
101510003375	FMN binding site [chemical binding]; other site
101510003376	2,4-decadienoyl-CoA binding site; other site
101510003377	catalytic residue [active]
101510003378	4Fe-4S cluster binding site [ion binding]; other site
101510003379	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
101510003380	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510003381	NAD(P) binding site [chemical binding]; other site
101510003382	active site
101510003383	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
101510003384	PhoQ Sensor; Region: PhoQ_Sensor; pfam08918
101510003385	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
101510003386	putative active site [active]
101510003387	putative substrate binding site [chemical binding]; other site
101510003388	catalytic site [active]
101510003389	dimer interface [polypeptide binding]; other site
101510003390	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
101510003391	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
101510003392	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
101510003393	catalytic triad [active]
101510003394	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510003395	Helix-turn-helix domains; Region: HTH; cl00088
101510003396	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
101510003397	Acyl transferase domain; Region: Acyl_transf_1; cl08282
101510003398	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
101510003399	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
101510003400	phosphate binding site [ion binding]; other site
101510003401	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
101510003402	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
101510003403	active site 2 [active]
101510003404	active site 1 [active]
101510003405	Acyl transferase domain; Region: Acyl_transf_1; cl08282
101510003406	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
101510003407	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
101510003408	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
101510003409	ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
101510003410	putative NAD(P) binding site [chemical binding]; other site
101510003411	active site
101510003412	'elongating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP) thioesters as...; Region: elong_cond_enzymes; cd00828
101510003413	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
101510003414	active site
101510003415	Glucitol operon activator protein (GutM); Region: GutM; cl01890
101510003416	Domain of unknown function (DUF3817); Region: DUF3817; cl14844
101510003417	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
101510003418	active site
101510003419	dimerization interface [polypeptide binding]; other site
101510003420	ribonuclease PH; Reviewed; Region: rph; PRK00173
101510003421	3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
101510003422	3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725
101510003423	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510003424	Rhomboid family; Region: Rhomboid; cl11446
101510003425	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
101510003426	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
101510003427	dimer interface [polypeptide binding]; other site
101510003428	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510003429	catalytic residue [active]
101510003430	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
101510003431	MoaE interaction surface [polypeptide binding]; other site
101510003432	MoeB interaction surface [polypeptide binding]; other site
101510003433	thiocarboxylated glycine; other site
101510003434	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
101510003435	MPN+ (JAMM) motif; other site
101510003436	Zinc-binding site [ion binding]; other site
101510003437	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
101510003438	putative active site pocket [active]
101510003439	cleavage site
101510003440	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
101510003441	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
101510003442	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
101510003443	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
101510003444	active site
101510003445	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
101510003446	Isochorismatase family; Region: Isochorismatase; pfam00857
101510003447	catalytic triad [active]
101510003448	metal binding site [ion binding]; metal-binding site
101510003449	conserved cis-peptide bond; other site
101510003450	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
101510003451	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510003452	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510003453	putative Mg++ binding site [ion binding]; other site
101510003454	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510003455	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
101510003456	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
101510003457	Walker A/P-loop; other site
101510003458	ATP binding site [chemical binding]; other site
101510003459	Q-loop/lid; other site
101510003460	ABC transporter signature motif; other site
101510003461	Walker B; other site
101510003462	D-loop; other site
101510003463	H-loop/switch region; other site
101510003464	ABC-2 type transporter; Region: ABC2_membrane; cl11417
101510003465	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
101510003466	putative homodimer interface [polypeptide binding]; other site
101510003467	putative active site pocket [active]
101510003468	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
101510003469	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
101510003470	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
101510003471	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
101510003472	active site
101510003473	homodimer interface [polypeptide binding]; other site
101510003474	catalytic site [active]
101510003475	acceptor binding site [chemical binding]; other site
101510003476	glycogen branching enzyme; Provisional; Region: PRK05402
101510003477	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
101510003478	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
101510003479	active site
101510003480	catalytic site [active]
101510003481	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
101510003482	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988
101510003483	D-galactonate transporter; Region: 2A0114; TIGR00893
101510003484	D-galactonate transporter; Region: 2A0114; TIGR00893
101510003485	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
101510003486	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
101510003487	Domain of unknown function (DUF3817); Region: DUF3817; cl14844
101510003488	putative acyltransferase; Provisional; Region: PRK05790
101510003489	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
101510003490	dimer interface [polypeptide binding]; other site
101510003491	active site
101510003492	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
101510003493	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510003494	dimer interface [polypeptide binding]; other site
101510003495	substrate binding site [chemical binding]; other site
101510003496	metal binding site [ion binding]; metal-binding site
101510003497	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
101510003498	Protein of unknown function DUF91; Region: DUF91; cl00709
101510003499	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
101510003500	dimerization interface [polypeptide binding]; other site
101510003501	cyclase homology domain; Region: CHD; cd07302
101510003502	nucleotidyl binding site; other site
101510003503	metal binding site [ion binding]; metal-binding site
101510003504	dimer interface [polypeptide binding]; other site
101510003505	Helix-turn-helix domains; Region: HTH; cl00088
101510003506	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
101510003507	SWIM zinc finger; Region: SWIM; cl15408
101510003508	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; cl09957
101510003509	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
101510003510	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
101510003511	3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356
101510003512	hinge; other site
101510003513	active site
101510003514	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
101510003515	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
101510003516	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
101510003517	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
101510003518	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
101510003519	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
101510003520	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
101510003521	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
101510003522	alpha subunit interaction interface [polypeptide binding]; other site
101510003523	Walker A motif; other site
101510003524	ATP binding site [chemical binding]; other site
101510003525	Walker B motif; other site
101510003526	inhibitor binding site; inhibition site
101510003527	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
101510003528	NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; cl00365
101510003529	F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422
101510003530	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
101510003531	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
101510003532	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
101510003533	beta subunit interaction interface [polypeptide binding]; other site
101510003534	Walker A motif; other site
101510003535	ATP binding site [chemical binding]; other site
101510003536	Walker B motif; other site
101510003537	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
101510003538	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl15360
101510003539	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
101510003540	Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975
101510003541	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
101510003542	ATP synthase subunit C; Region: ATP-synt_C; cl00466
101510003543	ATP synthase A chain; Region: ATP-synt_A; cl00413
101510003544	Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571
101510003545	Mg++ binding site [ion binding]; other site
101510003546	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
101510003547	putative catalytic motif [active]
101510003548	substrate binding site [chemical binding]; other site
101510003549	yrdC domain; Region: Sua5_yciO_yrdC; cl00305
101510003550	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
101510003551	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510003552	S-adenosylmethionine binding site [chemical binding]; other site
101510003553	peptide chain release factor 1; Validated; Region: prfA; PRK00591
101510003554	RF-1 domain; Region: RF-1; cl02875
101510003555	RF-1 domain; Region: RF-1; cl02875
101510003556	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
101510003557	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
101510003558	transcription termination factor Rho; Provisional; Region: PRK12608
101510003559	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
101510003560	RNA binding site [nucleotide binding]; other site
101510003561	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
101510003562	multimer interface [polypeptide binding]; other site
101510003563	Walker A motif; other site
101510003564	ATP binding site [chemical binding]; other site
101510003565	Walker B motif; other site
101510003566	homoserine kinase; Provisional; Region: PRK01212
101510003567	threonine synthase; Reviewed; Region: PRK06721
101510003568	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
101510003569	homodimer interface [polypeptide binding]; other site
101510003570	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510003571	catalytic residue [active]
101510003572	homoserine dehydrogenase; Provisional; Region: PRK06349
101510003573	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510003574	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
101510003575	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
101510003576	diaminopimelate decarboxylase; Region: lysA; TIGR01048
101510003577	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
101510003578	active site
101510003579	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
101510003580	substrate binding site [chemical binding]; other site
101510003581	catalytic residues [active]
101510003582	dimer interface [polypeptide binding]; other site
101510003583	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
101510003584	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104
101510003585	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
101510003586	active site
101510003587	HIGH motif; other site
101510003588	KMSK motif region; other site
101510003589	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
101510003590	tRNA binding surface [nucleotide binding]; other site
101510003591	anticodon binding site; other site
101510003592	Protein of unknown function (DUF3105); Region: DUF3105; pfam11303
101510003593	Domain of unknown function (DUF305); Region: DUF305; pfam03713
101510003594	Domain of unknown function (DUF305); Region: DUF305; pfam03713
101510003595	putative phosphoketolase; Provisional; Region: PRK05261
101510003596	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
101510003597	TPP-binding site [chemical binding]; other site
101510003598	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
101510003599	XFP C-terminal domain; Region: XFP_C; pfam09363
101510003600	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
101510003601	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
101510003602	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510003603	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510003604	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314
101510003605	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510003606	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
101510003607	RhlG and related beta-ketoacyl reductases, classical (c) SDRs; Region: RhlG_SDR_c; cd08942
101510003608	NADP binding site [chemical binding]; other site
101510003609	active site
101510003610	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
101510003611	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
101510003612	NAD(P) binding site [chemical binding]; other site
101510003613	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510003614	active site
101510003615	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510003616	active site
101510003617	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510003618	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510003619	NAD(P) binding site [chemical binding]; other site
101510003620	active site
101510003621	Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173
101510003622	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
101510003623	putative active site [active]
101510003624	putative substrate binding site [chemical binding]; other site
101510003625	ATP binding site [chemical binding]; other site
101510003626	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
101510003627	classical (c) SDRs; Region: SDR_c; cd05233
101510003628	NAD(P) binding site [chemical binding]; other site
101510003629	active site
101510003630	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510003631	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510003632	active site
101510003633	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510003634	enoyl-CoA hydratase; Provisional; Region: PRK06210
101510003635	substrate binding site [chemical binding]; other site
101510003636	oxyanion hole (OAH) forming residues; other site
101510003637	trimer interface [polypeptide binding]; other site
101510003638	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
101510003639	classical (c) SDRs; Region: SDR_c; cd05233
101510003640	NAD(P) binding site [chemical binding]; other site
101510003641	active site
101510003642	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
101510003643	putative active site [active]
101510003644	putative catalytic site [active]
101510003645	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
101510003646	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510003647	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
101510003648	Prostaglandin dehydrogenases; Region: PGDH; cd05288
101510003649	NAD(P) binding site [chemical binding]; other site
101510003650	substrate binding site [chemical binding]; other site
101510003651	dimer interface [polypeptide binding]; other site
101510003652	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
101510003653	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
101510003654	NAD(P) binding site [chemical binding]; other site
101510003655	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510003656	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510003657	putative substrate translocation pore; other site
101510003658	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510003659	Helix-turn-helix domains; Region: HTH; cl00088
101510003660	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510003661	Helix-turn-helix domains; Region: HTH; cl00088
101510003662	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
101510003663	active site
101510003664	substrate binding pocket [chemical binding]; other site
101510003665	homodimer interaction site [polypeptide binding]; other site
101510003666	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
101510003667	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510003668	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638
101510003669	active site
101510003670	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
101510003671	CysN_ATPS subfamily.  CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes.  ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate.  CysD, which...; Region: CysN_ATPS; cd04166
101510003672	CysD dimerization site [polypeptide binding]; other site
101510003673	G1 box; other site
101510003674	putative GEF interaction site [polypeptide binding]; other site
101510003675	GTP/Mg2+ binding site [chemical binding]; other site
101510003676	Switch I region; other site
101510003677	G2 box; other site
101510003678	G3 box; other site
101510003679	Switch II region; other site
101510003680	G4 box; other site
101510003681	G5 box; other site
101510003682	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
101510003683	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
101510003684	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027
101510003685	ligand-binding site [chemical binding]; other site
101510003686	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
101510003687	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
101510003688	Active Sites [active]
101510003689	Helix-turn-helix domains; Region: HTH; cl00088
101510003690	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
101510003691	classical (c) SDRs; Region: SDR_c; cd05233
101510003692	NAD(P) binding site [chemical binding]; other site
101510003693	active site
101510003694	Sulfotransferase family; Region: Sulfotransfer_3; cl14559
101510003695	Low molecular weight phosphatase family; Region: LMWPc; cl00105
101510003696	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
101510003697	active site
101510003698	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
101510003699	oligomer interface [polypeptide binding]; other site
101510003700	active site residues [active]
101510003701	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
101510003702	oligomer interface [polypeptide binding]; other site
101510003703	active site residues [active]
101510003704	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
101510003705	non-specific DNA binding site [nucleotide binding]; other site
101510003706	salt bridge; other site
101510003707	sequence-specific DNA binding site [nucleotide binding]; other site
101510003708	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510003709	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510003710	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
101510003711	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
101510003712	active site
101510003713	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
101510003714	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510003715	Helix-turn-helix domains; Region: HTH; cl00088
101510003716	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
101510003717	putative hydrophobic ligand binding site [chemical binding]; other site
101510003718	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
101510003719	putative DNA binding site [nucleotide binding]; other site
101510003720	dimerization interface [polypeptide binding]; other site
101510003721	putative Zn2+ binding site [ion binding]; other site
101510003722	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
101510003723	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510003724	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510003725	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510003726	putative substrate translocation pore; other site
101510003727	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510003728	putative substrate translocation pore; other site
101510003729	Transcriptional regulators [Transcription]; Region: MarR; COG1846
101510003730	Helix-turn-helix domains; Region: HTH; cl00088
101510003731	enoyl-CoA hydratase; Provisional; Region: PRK05862
101510003732	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510003733	substrate binding site [chemical binding]; other site
101510003734	oxyanion hole (OAH) forming residues; other site
101510003735	trimer interface [polypeptide binding]; other site
101510003736	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510003737	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
101510003738	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
101510003739	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510003740	substrate binding site [chemical binding]; other site
101510003741	oxyanion hole (OAH) forming residues; other site
101510003742	trimer interface [polypeptide binding]; other site
101510003743	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510003744	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
101510003745	substrate binding pocket [chemical binding]; other site
101510003746	FAD binding site [chemical binding]; other site
101510003747	catalytic base [active]
101510003748	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
101510003749	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510003750	tetrameric interface [polypeptide binding]; other site
101510003751	NAD binding site [chemical binding]; other site
101510003752	catalytic residues [active]
101510003753	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
101510003754	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
101510003755	active site
101510003756	CutC family; Region: CutC; cl01218
101510003757	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
101510003758	active site
101510003759	trimer interface [polypeptide binding]; other site
101510003760	allosteric site; other site
101510003761	active site lid [active]
101510003762	hexamer (dimer of trimers) interface [polypeptide binding]; other site
101510003763	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
101510003764	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
101510003765	active site
101510003766	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
101510003767	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
101510003768	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
101510003769	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
101510003770	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
101510003771	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
101510003772	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
101510003773	active site turn [active]
101510003774	phosphorylation site [posttranslational modification]
101510003775	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
101510003776	HPr interaction site; other site
101510003777	glycerol kinase (GK) interaction site [polypeptide binding]; other site
101510003778	active site
101510003779	phosphorylation site [posttranslational modification]
101510003780	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
101510003781	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510003782	DNA-binding site [nucleotide binding]; DNA binding site
101510003783	UTRA domain; Region: UTRA; cl01230
101510003784	Domain of unknown function (DUF1990); Region: DUF1990; cl01969
101510003785	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
101510003786	FAD binding domain; Region: FAD_binding_4; pfam01565
101510003787	Berberine and berberine like; Region: BBE; pfam08031
101510003788	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
101510003789	Helix-turn-helix domains; Region: HTH; cl00088
101510003790	TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903
101510003791	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
101510003792	binding surface
101510003793	TPR motif; other site
101510003794	SWIM zinc finger; Region: SWIM; cl15408
101510003795	SNF2 Helicase protein; Region: DUF3670; pfam12419
101510003796	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
101510003797	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
101510003798	ATP binding site [chemical binding]; other site
101510003799	putative Mg++ binding site [ion binding]; other site
101510003800	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
101510003801	nucleotide binding region [chemical binding]; other site
101510003802	ATP-binding site [chemical binding]; other site
101510003803	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
101510003804	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
101510003805	putative NAD(P) binding site [chemical binding]; other site
101510003806	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
101510003807	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
101510003808	Moco binding site; other site
101510003809	metal coordination site [ion binding]; other site
101510003810	dimerization interface [polypeptide binding]; other site
101510003811	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
101510003812	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
101510003813	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
101510003814	shikimate binding site; other site
101510003815	NAD(P) binding site [chemical binding]; other site
101510003816	OHCU decarboxylase; Region: OHCU_decarbox; cl01251
101510003817	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
101510003818	active site
101510003819	homotetramer interface [polypeptide binding]; other site
101510003820	urate oxidase; Region: urate_oxi; TIGR03383
101510003821	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
101510003822	active site
101510003823	Permease family; Region: Xan_ur_permease; cl00967
101510003824	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
101510003825	Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908
101510003826	putative ADP-ribose binding site [chemical binding]; other site
101510003827	putative active site [active]
101510003828	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
101510003829	Permease family; Region: Xan_ur_permease; cl00967
101510003830	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
101510003831	active site
101510003832	Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173
101510003833	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
101510003834	putative active site [active]
101510003835	putative substrate binding site [chemical binding]; other site
101510003836	ATP binding site [chemical binding]; other site
101510003837	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
101510003838	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
101510003839	TPP-binding site [chemical binding]; other site
101510003840	tetramer interface [polypeptide binding]; other site
101510003841	heterodimer interface [polypeptide binding]; other site
101510003842	phosphorylation loop region [posttranslational modification]
101510003843	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
101510003844	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
101510003845	alpha subunit interface [polypeptide binding]; other site
101510003846	TPP binding site [chemical binding]; other site
101510003847	heterodimer interface [polypeptide binding]; other site
101510003848	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
101510003849	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
101510003850	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
101510003851	E3 interaction surface; other site
101510003852	lipoyl attachment site [posttranslational modification]; other site
101510003853	e3 binding domain; Region: E3_binding; pfam02817
101510003854	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
101510003855	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510003856	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
101510003857	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
101510003858	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
101510003859	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
101510003860	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
101510003861	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
101510003862	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
101510003863	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
101510003864	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
101510003865	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
101510003866	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510003867	Protein of unknown function, DUF488; Region: DUF488; cl01246
101510003868	acyl-CoA synthetase; Provisional; Region: PRK13391
101510003869	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510003870	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
101510003871	DinB superfamily; Region: DinB_2; cl00986
101510003872	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129
101510003873	catalytic triad [active]
101510003874	active site nucleophile [active]
101510003875	FAD binding domain; Region: FAD_binding_4; pfam01565
101510003876	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
101510003877	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
101510003878	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
101510003879	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
101510003880	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
101510003881	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510003882	H+ Antiporter protein; Region: 2A0121; TIGR00900
101510003883	putative substrate translocation pore; other site
101510003884	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
101510003885	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510003886	substrate binding pocket [chemical binding]; other site
101510003887	catalytic triad [active]
101510003888	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
101510003889	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
101510003890	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243
101510003891	NMT1/THI5 like; Region: NMT1; pfam09084
101510003892	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510003893	dimer interface [polypeptide binding]; other site
101510003894	conserved gate region; other site
101510003895	putative PBP binding loops; other site
101510003896	ABC-ATPase subunit interface; other site
101510003897	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
101510003898	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
101510003899	Walker A/P-loop; other site
101510003900	ATP binding site [chemical binding]; other site
101510003901	Q-loop/lid; other site
101510003902	ABC transporter signature motif; other site
101510003903	Walker B; other site
101510003904	D-loop; other site
101510003905	H-loop/switch region; other site
101510003906	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
101510003907	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
101510003908	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
101510003909	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510003910	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
101510003911	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
101510003912	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
101510003913	domain; Region: Succ_DH_flav_C; pfam02910
101510003914	EspG family; Region: ESX-1_EspG; pfam14011
101510003915	Integrase core domain; Region: rve; cl01316
101510003916	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
101510003917	oxalacetate binding site [chemical binding]; other site
101510003918	citrylCoA binding site [chemical binding]; other site
101510003919	coenzyme A binding site [chemical binding]; other site
101510003920	catalytic triad [active]
101510003921	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
101510003922	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
101510003923	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
101510003924	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510003925	S-adenosylmethionine binding site [chemical binding]; other site
101510003926	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
101510003927	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
101510003928	NAD(P) binding site [chemical binding]; other site
101510003929	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
101510003930	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510003931	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510003932	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510003933	putative substrate translocation pore; other site
101510003934	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
101510003935	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510003936	NAD(P) binding site [chemical binding]; other site
101510003937	active site
101510003938	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510003939	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510003940	active site
101510003941	putative acyltransferase; Provisional; Region: PRK05790
101510003942	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
101510003943	dimer interface [polypeptide binding]; other site
101510003944	active site
101510003945	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510003946	Helix-turn-helix domains; Region: HTH; cl00088
101510003947	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510003948	Helix-turn-helix domains; Region: HTH; cl00088
101510003949	Helix-turn-helix domains; Region: HTH; cl00088
101510003950	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510003951	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
101510003952	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208
101510003953	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
101510003954	NAD binding site [chemical binding]; other site
101510003955	Phe binding site; other site
101510003956	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
101510003957	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
101510003958	dimer interface [polypeptide binding]; other site
101510003959	PYR/PP interface [polypeptide binding]; other site
101510003960	TPP binding site [chemical binding]; other site
101510003961	substrate binding site [chemical binding]; other site
101510003962	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
101510003963	TPP-binding site [chemical binding]; other site
101510003964	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
101510003965	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
101510003966	Helix-turn-helix domains; Region: HTH; cl00088
101510003967	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208
101510003968	active site
101510003969	homopentamer interface [polypeptide binding]; other site
101510003970	dimer interface [polypeptide binding]; other site
101510003971	Restriction endonuclease; Region: Mrr_cat; cl00747
101510003972	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
101510003973	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
101510003974	putative NAD(P) binding site [chemical binding]; other site
101510003975	catalytic Zn binding site [ion binding]; other site
101510003976	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
101510003977	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
101510003978	Sodium:solute symporter family; Region: SSF; cl00456
101510003979	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510003980	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
101510003981	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
101510003982	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
101510003983	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
101510003984	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510003985	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510003986	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
101510003987	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
101510003988	FAD binding domain; Region: FAD_binding_4; pfam01565
101510003989	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
101510003990	Domain of unknown function (DUF427); Region: DUF427; cl00998
101510003991	Domain of unknown function (DUF427); Region: DUF427; cl00998
101510003992	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510003993	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
101510003994	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
101510003995	Probable transposase; Region: OrfB_IS605; pfam01385
101510003996	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
101510003997	ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180
101510003998	Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901
101510003999	active site
101510004000	DNA binding site [nucleotide binding]
101510004001	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
101510004002	DNA binding site [nucleotide binding]
101510004003	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
101510004004	putative dimer interface [polypeptide binding]; other site
101510004005	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510004006	short chain dehydrogenase; Provisional; Region: PRK06123
101510004007	classical (c) SDRs; Region: SDR_c; cd05233
101510004008	NAD(P) binding site [chemical binding]; other site
101510004009	active site
101510004010	Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763
101510004011	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
101510004012	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
101510004013	ATP binding site [chemical binding]; other site
101510004014	putative Mg++ binding site [ion binding]; other site
101510004015	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
101510004016	nucleotide binding region [chemical binding]; other site
101510004017	ATP-binding site [chemical binding]; other site
101510004018	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
101510004019	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
101510004020	Flavin Reductases; Region: FlaRed; cl00801
101510004021	Protein of unknown function (DUF3184); Region: DUF3184; pfam11380
101510004022	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
101510004023	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
101510004024	DNA binding residues [nucleotide binding]
101510004025	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
101510004026	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
101510004027	active site
101510004028	metal binding site [ion binding]; metal-binding site
101510004029	hexamer interface [polypeptide binding]; other site
101510004030	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
101510004031	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
101510004032	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
101510004033	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
101510004034	TM2 domain; Region: TM2; cl00984
101510004035	Transposase domain (DUF772); Region: DUF772; cl15789
101510004036	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
101510004037	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
101510004038	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
101510004039	Transposase, Mutator family; Region: Transposase_mut; pfam00872
101510004040	cell division protein ZipA; Provisional; Region: PRK03427
101510004041	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
101510004042	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
101510004043	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
101510004044	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
101510004045	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
101510004046	DNA binding residues [nucleotide binding]
101510004047	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
101510004048	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
101510004049	Magnesium ion binding site [ion binding]; other site
101510004050	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
101510004051	ATP binding site [chemical binding]; other site
101510004052	putative Mg++ binding site [ion binding]; other site
101510004053	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
101510004054	nucleotide binding region [chemical binding]; other site
101510004055	DNA helicase, putative; Region: TIGR00376
101510004056	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510004057	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
101510004058	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
101510004059	putative active site [active]
101510004060	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
101510004061	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
101510004062	putative metal binding site [ion binding]; other site
101510004063	Protein of unknown function DUF262; Region: DUF262; cl14890
101510004064	Domain of unknown function (DUF1994); Region: DUF1994; cl09179
101510004065	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719
101510004066	GIY-YIG motif/motif A; other site
101510004067	active site
101510004068	catalytic site [active]
101510004069	metal binding site [ion binding]; metal-binding site
101510004070	Tubulin like; Region: Tubulin_2; pfam13809
101510004071	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
101510004072	Nuclease-related domain; Region: NERD; pfam08378
101510004073	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972
101510004074	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510004075	Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110
101510004076	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
101510004077	putative metal binding site [ion binding]; other site
101510004078	Uncharacterised protein family UPF0047; Region: UPF0047; cl00439
101510004079	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
101510004080	Helix-turn-helix domains; Region: HTH; cl00088
101510004081	CarD-like/TRCF domain; Region: CarD_TRCF; cl00588
101510004082	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510004083	DNA polymerase IV; Validated; Region: PRK03352
101510004084	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
101510004085	active site
101510004086	DNA binding site [nucleotide binding]
101510004087	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
101510004088	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
101510004089	active site
101510004090	ATP binding site [chemical binding]; other site
101510004091	substrate binding site [chemical binding]; other site
101510004092	activation loop (A-loop); other site
101510004093	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510004094	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
101510004095	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
101510004096	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
101510004097	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
101510004098	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
101510004099	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
101510004100	putative hydrophobic ligand binding site [chemical binding]; other site
101510004101	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510004102	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510004103	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
101510004104	active site
101510004105	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
101510004106	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
101510004107	putative active site [active]
101510004108	putative catalytic site [active]
101510004109	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
101510004110	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
101510004111	putative di-iron ligands [ion binding]; other site
101510004112	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
101510004113	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
101510004114	Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775
101510004115	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
101510004116	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
101510004117	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
101510004118	NAD(P) binding site [chemical binding]; other site
101510004119	catalytic residues [active]
101510004120	choline dehydrogenase; Validated; Region: PRK02106
101510004121	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
101510004122	NlpC/P60 family; Region: NLPC_P60; cl11438
101510004123	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510004124	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510004125	NMT1/THI5 like; Region: NMT1; pfam09084
101510004126	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
101510004127	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
101510004128	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
101510004129	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
101510004130	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
101510004131	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510004132	Helix-turn-helix domains; Region: HTH; cl00088
101510004133	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510004134	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
101510004135	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
101510004136	active site
101510004137	non-prolyl cis peptide bond; other site
101510004138	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510004139	active site
101510004140	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510004141	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
101510004142	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510004143	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
101510004144	MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport.  Other members of this system include the MetP permease and  the MetQ substrate binding protein.  ABC...; Region: ABC_MetN_methionine_transporter; cd03258
101510004145	Walker A/P-loop; other site
101510004146	ATP binding site [chemical binding]; other site
101510004147	Q-loop/lid; other site
101510004148	ABC transporter signature motif; other site
101510004149	Walker B; other site
101510004150	D-loop; other site
101510004151	H-loop/switch region; other site
101510004152	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510004153	dimer interface [polypeptide binding]; other site
101510004154	conserved gate region; other site
101510004155	ABC-ATPase subunit interface; other site
101510004156	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
101510004157	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
101510004158	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
101510004159	active site
101510004160	non-prolyl cis peptide bond; other site
101510004161	Helix-turn-helix domains; Region: HTH; cl00088
101510004162	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
101510004163	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
101510004164	putative NAD(P) binding site [chemical binding]; other site
101510004165	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510004166	S-adenosylmethionine binding site [chemical binding]; other site
101510004167	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
101510004168	non-specific DNA binding site [nucleotide binding]; other site
101510004169	salt bridge; other site
101510004170	sequence-specific DNA binding site [nucleotide binding]; other site
101510004171	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
101510004172	active site
101510004173	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
101510004174	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
101510004175	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
101510004176	Flavin Reductases; Region: FlaRed; cl00801
101510004177	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
101510004178	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
101510004179	MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport.  Other members of this system include the MetP permease and  the MetQ substrate binding protein.  ABC...; Region: ABC_MetN_methionine_transporter; cd03258
101510004180	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
101510004181	Walker A/P-loop; other site
101510004182	ATP binding site [chemical binding]; other site
101510004183	Q-loop/lid; other site
101510004184	ABC transporter signature motif; other site
101510004185	Walker B; other site
101510004186	D-loop; other site
101510004187	H-loop/switch region; other site
101510004188	NIL domain; Region: NIL; cl09633
101510004189	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
101510004190	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
101510004191	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
101510004192	Walker A/P-loop; other site
101510004193	ATP binding site [chemical binding]; other site
101510004194	Q-loop/lid; other site
101510004195	ABC transporter signature motif; other site
101510004196	Walker B; other site
101510004197	D-loop; other site
101510004198	H-loop/switch region; other site
101510004199	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
101510004200	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
101510004201	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
101510004202	Walker A/P-loop; other site
101510004203	ATP binding site [chemical binding]; other site
101510004204	Q-loop/lid; other site
101510004205	ABC transporter signature motif; other site
101510004206	Walker B; other site
101510004207	D-loop; other site
101510004208	H-loop/switch region; other site
101510004209	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
101510004210	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
101510004211	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510004212	dimer interface [polypeptide binding]; other site
101510004213	conserved gate region; other site
101510004214	putative PBP binding loops; other site
101510004215	ABC-ATPase subunit interface; other site
101510004216	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
101510004217	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510004218	dimer interface [polypeptide binding]; other site
101510004219	conserved gate region; other site
101510004220	putative PBP binding loops; other site
101510004221	ABC-ATPase subunit interface; other site
101510004222	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_9; cd08496
101510004223	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
101510004224	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
101510004225	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
101510004226	active site
101510004227	non-prolyl cis peptide bond; other site
101510004228	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510004229	DNA-binding site [nucleotide binding]; DNA binding site
101510004230	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
101510004231	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
101510004232	catalytic residue [active]
101510004233	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510004234	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
101510004235	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510004236	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
101510004237	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
101510004238	homodimer interface [polypeptide binding]; other site
101510004239	substrate-cofactor binding pocket; other site
101510004240	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510004241	catalytic residue [active]
101510004242	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
101510004243	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
101510004244	active site
101510004245	dimer interface [polypeptide binding]; other site
101510004246	non-prolyl cis peptide bond; other site
101510004247	insertion regions; other site
101510004248	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
101510004249	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510004250	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510004251	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510004252	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510004253	NAD(P) binding site [chemical binding]; other site
101510004254	active site
101510004255	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
101510004256	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510004257	NAD binding site [chemical binding]; other site
101510004258	catalytic residues [active]
101510004259	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
101510004260	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
101510004261	tellurite resistance protein terB; Region: terB; cd07176
101510004262	putative metal binding site [ion binding]; other site
101510004263	Sodium:solute symporter family; Region: SSF; cl00456
101510004264	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
101510004265	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510004266	active site
101510004267	metal binding site [ion binding]; metal-binding site
101510004268	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
101510004269	amidohydrolase; Region: amidohydrolases; TIGR01891
101510004270	metal binding site [ion binding]; metal-binding site
101510004271	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
101510004272	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
101510004273	homotrimer interaction site [polypeptide binding]; other site
101510004274	putative active site [active]
101510004275	4-hydroxyphenylacetate 3-hydroxylase N terminal; Region: HpaB_N; pfam11794
101510004276	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
101510004277	Flavin Reductases; Region: FlaRed; cl00801
101510004278	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
101510004279	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
101510004280	Transcriptional regulator [Transcription]; Region: LysR; COG0583
101510004281	Helix-turn-helix domains; Region: HTH; cl00088
101510004282	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
101510004283	putative substrate binding pocket [chemical binding]; other site
101510004284	dimerization interface [polypeptide binding]; other site
101510004285	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
101510004286	Amino acid permease; Region: AA_permease; cl00524
101510004287	Trimethylamine dehydrogenase (TMADH) and histamine dehydrogenase (HD) FMN-binding domain.  TMADH is an iron-sulfur flavoprotein that catalyzes the oxidative demethylation of trimethylamine to form dimethylamine and formaldehyde. The protein forms a...; Region: TMADH_HD_FMN; cd02929
101510004288	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
101510004289	FMN binding site [chemical binding]; other site
101510004290	active site
101510004291	homodimer interface [polypeptide binding]; other site
101510004292	putative catalytic residue [active]
101510004293	4Fe-4S cluster binding site [ion binding]; other site
101510004294	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510004295	Cupin domain; Region: Cupin_2; cl09118
101510004296	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510004297	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
101510004298	NAD(P) binding site [chemical binding]; other site
101510004299	catalytic residues [active]
101510004300	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
101510004301	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
101510004302	flavanone-3-hydroxylase; Provisional; Region: PLN03176
101510004303	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206
101510004304	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
101510004305	Domain of unknown function (DUF385); Region: DUF385; cl04387
101510004306	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
101510004307	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
101510004308	active site
101510004309	dimer interface [polypeptide binding]; other site
101510004310	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
101510004311	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
101510004312	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
101510004313	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
101510004314	active site
101510004315	FMN binding site [chemical binding]; other site
101510004316	substrate binding site [chemical binding]; other site
101510004317	3Fe-4S cluster binding site [ion binding]; other site
101510004318	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
101510004319	domain interface; other site
101510004320	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
101510004321	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
101510004322	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
101510004323	FAD binding pocket [chemical binding]; other site
101510004324	FAD binding motif [chemical binding]; other site
101510004325	catalytic residues [active]
101510004326	NAD binding pocket [chemical binding]; other site
101510004327	phosphate binding motif [ion binding]; other site
101510004328	beta-alpha-beta structure motif; other site
101510004329	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
101510004330	PaaX-like protein; Region: PaaX; pfam07848
101510004331	phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277
101510004332	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
101510004333	kynureninase; Region: kynureninase; TIGR01814
101510004334	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
101510004335	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
101510004336	catalytic residue [active]
101510004337	Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994
101510004338	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
101510004339	NADP binding site [chemical binding]; other site
101510004340	active site
101510004341	regulatory binding site [polypeptide binding]; other site
101510004342	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
101510004343	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
101510004344	choline dehydrogenase; Validated; Region: PRK02106
101510004345	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
101510004346	Amino acid permease; Region: AA_permease; cl00524
101510004347	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
101510004348	Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
101510004349	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510004350	tetramerization interface [polypeptide binding]; other site
101510004351	NAD(P) binding site [chemical binding]; other site
101510004352	catalytic residues [active]
101510004353	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
101510004354	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
101510004355	[2Fe-2S] cluster binding site [ion binding]; other site
101510004356	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
101510004357	hydrophobic ligand binding site; other site
101510004358	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510004359	Helix-turn-helix domains; Region: HTH; cl00088
101510004360	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510004361	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
101510004362	[2Fe-2S] cluster binding site [ion binding]; other site
101510004363	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
101510004364	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510004365	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510004366	Helix-turn-helix domains; Region: HTH; cl00088
101510004367	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510004368	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
101510004369	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510004370	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
101510004371	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
101510004372	Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350
101510004373	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189
101510004374	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
101510004375	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
101510004376	homodimer interface [polypeptide binding]; other site
101510004377	NADP binding site [chemical binding]; other site
101510004378	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
101510004379	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
101510004380	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
101510004381	putative active site [active]
101510004382	putative substrate binding site [chemical binding]; other site
101510004383	putative cosubstrate binding site; other site
101510004384	catalytic site [active]
101510004385	Transcriptional regulators [Transcription]; Region: GntR; COG1802
101510004386	Helix-turn-helix domains; Region: HTH; cl00088
101510004387	FCD domain; Region: FCD; cl11656
101510004388	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
101510004389	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
101510004390	dimer interface [polypeptide binding]; other site
101510004391	glycine-pyridoxal phosphate binding site [chemical binding]; other site
101510004392	active site
101510004393	folate binding site [chemical binding]; other site
101510004394	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510004395	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
101510004396	Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767
101510004397	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
101510004398	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
101510004399	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
101510004400	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
101510004401	dihydropteroate synthase; Region: DHPS; TIGR01496
101510004402	substrate binding pocket [chemical binding]; other site
101510004403	dimer interface [polypeptide binding]; other site
101510004404	inhibitor binding site; inhibition site
101510004405	Aminotransferase class IV; Region: Aminotran_4; pfam01063
101510004406	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224
101510004407	substrate-cofactor binding pocket; other site
101510004408	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
101510004409	lipoyl attachment site [posttranslational modification]; other site
101510004410	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
101510004411	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
101510004412	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
101510004413	DNA polymerase III subunit epsilon; Provisional; Region: PRK06063
101510004414	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
101510004415	active site
101510004416	substrate binding site [chemical binding]; other site
101510004417	catalytic site [active]
101510004418	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038
101510004419	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
101510004420	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
101510004421	putative metal binding site [ion binding]; other site
101510004422	Excalibur calcium-binding domain; Region: Excalibur; cl05460
101510004423	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
101510004424	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
101510004425	Predicted membrane protein [Function unknown]; Region: COG4270
101510004426	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
101510004427	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510004428	Putative ATPase (DUF699); Region: DUF699; pfam05127
101510004429	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
101510004430	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510004431	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
101510004432	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510004433	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510004434	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
101510004435	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl15476
101510004436	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
101510004437	GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440
101510004438	GIY-YIG motif/motif A; other site
101510004439	putative active site [active]
101510004440	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
101510004441	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
101510004442	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
101510004443	dihydroxyacetone kinase; Provisional; Region: PRK14479
101510004444	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
101510004445	DAK2 domain; Region: Dak2; cl03685
101510004446	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
101510004447	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510004448	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510004449	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510004450	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510004451	putative substrate translocation pore; other site
101510004452	Transcriptional regulator [Transcription]; Region: LysR; COG0583
101510004453	Helix-turn-helix domains; Region: HTH; cl00088
101510004454	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
101510004455	putative substrate binding pocket [chemical binding]; other site
101510004456	dimerization interface [polypeptide binding]; other site
101510004457	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
101510004458	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510004459	putative succinate dehydrogenase; Reviewed; Region: PRK12842
101510004460	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
101510004461	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510004462	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
101510004463	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
101510004464	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
101510004465	active site
101510004466	catalytic tetrad [active]
101510004467	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
101510004468	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
101510004469	active site
101510004470	FMN binding site [chemical binding]; other site
101510004471	substrate binding site [chemical binding]; other site
101510004472	putative catalytic residue [active]
101510004473	shikimate 5-dehydrogenase; Reviewed; Region: PRK12549
101510004474	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
101510004475	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
101510004476	shikimate binding site; other site
101510004477	NAD(P) binding site [chemical binding]; other site
101510004478	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510004479	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510004480	putative substrate translocation pore; other site
101510004481	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
101510004482	Helix-turn-helix domains; Region: HTH; cl00088
101510004483	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
101510004484	dimerization interface [polypeptide binding]; other site
101510004485	substrate binding pocket [chemical binding]; other site
101510004486	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510004487	classical (c) SDRs; Region: SDR_c; cd05233
101510004488	NAD(P) binding site [chemical binding]; other site
101510004489	active site
101510004490	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl01383
101510004491	chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465
101510004492	active site
101510004493	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
101510004494	Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177
101510004495	active site
101510004496	dimer interface [polypeptide binding]; other site
101510004497	metal binding site [ion binding]; metal-binding site
101510004498	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
101510004499	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
101510004500	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510004501	Helix-turn-helix domains; Region: HTH; cl00088
101510004502	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510004503	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510004504	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510004505	benzoate transport; Region: 2A0115; TIGR00895
101510004506	putative substrate translocation pore; other site
101510004507	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510004508	mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583
101510004509	DinB superfamily; Region: DinB_2; cl00986
101510004510	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
101510004511	Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435
101510004512	Cupin domain; Region: Cupin_2; cl09118
101510004513	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510004514	Helix-turn-helix domains; Region: HTH; cl00088
101510004515	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510004516	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510004517	putative substrate translocation pore; other site
101510004518	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510004519	salicylate hydroxylase; Provisional; Region: PRK08163
101510004520	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
101510004521	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
101510004522	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
101510004523	active site
101510004524	FMN binding site [chemical binding]; other site
101510004525	substrate binding site [chemical binding]; other site
101510004526	3Fe-4S cluster binding site [ion binding]; other site
101510004527	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510004528	Helix-turn-helix domains; Region: HTH; cl00088
101510004529	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
101510004530	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
101510004531	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
101510004532	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510004533	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510004534	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510004535	active site
101510004536	putative acyltransferase; Provisional; Region: PRK05790
101510004537	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
101510004538	dimer interface [polypeptide binding]; other site
101510004539	active site
101510004540	choline dehydrogenase; Validated; Region: PRK02106
101510004541	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510004542	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
101510004543	Amino acid permease; Region: AA_permease; cl00524
101510004544	Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
101510004545	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510004546	tetramerization interface [polypeptide binding]; other site
101510004547	NAD(P) binding site [chemical binding]; other site
101510004548	catalytic residues [active]
101510004549	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
101510004550	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
101510004551	active site
101510004552	catalytic tetrad [active]
101510004553	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
101510004554	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510004555	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510004556	NAD(P) binding site [chemical binding]; other site
101510004557	active site
101510004558	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510004559	classical (c) SDRs; Region: SDR_c; cd05233
101510004560	NAD(P) binding site [chemical binding]; other site
101510004561	active site
101510004562	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
101510004563	classical (c) SDRs; Region: SDR_c; cd05233
101510004564	NAD(P) binding site [chemical binding]; other site
101510004565	active site
101510004566	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
101510004567	DinB superfamily; Region: DinB_2; cl00986
101510004568	Protein of unknown function (DUF2927); Region: DUF2927; pfam11150
101510004569	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
101510004570	active site
101510004571	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
101510004572	HipA N-terminal domain; Region: couple_hipA; TIGR03071
101510004573	HipA-like N-terminal domain; Region: HipA_N; pfam07805
101510004574	HipA-like C-terminal domain; Region: HipA_C; pfam07804
101510004575	endonuclease IV; Provisional; Region: PRK01060
101510004576	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
101510004577	AP (apurinic/apyrimidinic) site pocket; other site
101510004578	DNA interaction; other site
101510004579	Metal-binding active site; metal-binding site
101510004580	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
101510004581	Permease family; Region: Xan_ur_permease; cl00967
101510004582	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
101510004583	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
101510004584	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
101510004585	substrate binding pocket [chemical binding]; other site
101510004586	membrane-bound complex binding site; other site
101510004587	hinge residues; other site
101510004588	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
101510004589	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510004590	dimer interface [polypeptide binding]; other site
101510004591	conserved gate region; other site
101510004592	putative PBP binding loops; other site
101510004593	ABC-ATPase subunit interface; other site
101510004594	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
101510004595	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
101510004596	Walker A/P-loop; other site
101510004597	ATP binding site [chemical binding]; other site
101510004598	Q-loop/lid; other site
101510004599	ABC transporter signature motif; other site
101510004600	Walker B; other site
101510004601	D-loop; other site
101510004602	H-loop/switch region; other site
101510004603	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
101510004604	Secretory lipase; Region: LIP; pfam03583
101510004605	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
101510004606	active site
101510004607	nucleophile elbow; other site
101510004608	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
101510004609	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510004610	Helix-turn-helix domains; Region: HTH; cl00088
101510004611	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
101510004612	Coenzyme A binding pocket [chemical binding]; other site
101510004613	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
101510004614	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
101510004615	putative hydrophobic ligand binding site [chemical binding]; other site
101510004616	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
101510004617	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
101510004618	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
101510004619	metal ion-dependent adhesion site (MIDAS); other site
101510004620	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
101510004621	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
101510004622	active site
101510004623	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
101510004624	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510004625	active site
101510004626	Protein of unknown function (DUF322); Region: DUF322; cl00574
101510004627	Protein of unknown function (DUF322); Region: DUF322; cl00574
101510004628	Protein of unknown function (DUF322); Region: DUF322; cl00574
101510004629	YCII-related domain; Region: YCII; cl00999
101510004630	elongation factor Tu; Reviewed; Region: PRK00049
101510004631	EF-Tu subfamily.  This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts.  It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884
101510004632	G1 box; other site
101510004633	GEF interaction site [polypeptide binding]; other site
101510004634	GTP/Mg2+ binding site [chemical binding]; other site
101510004635	Switch I region; other site
101510004636	G2 box; other site
101510004637	G3 box; other site
101510004638	Switch II region; other site
101510004639	G4 box; other site
101510004640	G5 box; other site
101510004641	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
101510004642	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
101510004643	Antibiotic Binding Site [chemical binding]; other site
101510004644	elongation factor G; Reviewed; Region: PRK00007
101510004645	Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase).  The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA.  This is an example of molecular mimicry; a protein domain evolved so...; Region: EF-G; cd01886
101510004646	G1 box; other site
101510004647	putative GEF interaction site [polypeptide binding]; other site
101510004648	GTP/Mg2+ binding site [chemical binding]; other site
101510004649	Switch I region; other site
101510004650	G2 box; other site
101510004651	G3 box; other site
101510004652	Switch II region; other site
101510004653	G4 box; other site
101510004654	G5 box; other site
101510004655	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
101510004656	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
101510004657	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
101510004658	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
101510004659	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
101510004660	S17 interaction site [polypeptide binding]; other site
101510004661	S8 interaction site; other site
101510004662	16S rRNA interaction site [nucleotide binding]; other site
101510004663	streptomycin interaction site [chemical binding]; other site
101510004664	23S rRNA interaction site [nucleotide binding]; other site
101510004665	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
101510004666	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
101510004667	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
101510004668	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510004669	Helix-turn-helix domains; Region: HTH; cl00088
101510004670	enoyl-CoA hydratase; Provisional; Region: PRK07827
101510004671	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510004672	substrate binding site [chemical binding]; other site
101510004673	oxyanion hole (OAH) forming residues; other site
101510004674	trimer interface [polypeptide binding]; other site
101510004675	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510004676	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
101510004677	active site
101510004678	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
101510004679	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
101510004680	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
101510004681	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
101510004682	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
101510004683	carboxyltransferase (CT) interaction site; other site
101510004684	biotinylation site [posttranslational modification]; other site
101510004685	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
101510004686	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780
101510004687	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510004688	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510004689	active site
101510004690	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
101510004691	TIGR03084 family protein; Region: TIGR03084
101510004692	DinB superfamily; Region: DinB_2; cl00986
101510004693	Wyosine base formation; Region: Wyosine_form; pfam08608
101510004694	short chain dehydrogenase; Provisional; Region: PRK05866
101510004695	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510004696	NAD(P) binding site [chemical binding]; other site
101510004697	active site
101510004698	enoyl-CoA hydratase; Provisional; Region: PRK09245
101510004699	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510004700	substrate binding site [chemical binding]; other site
101510004701	oxyanion hole (OAH) forming residues; other site
101510004702	trimer interface [polypeptide binding]; other site
101510004703	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
101510004704	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
101510004705	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
101510004706	Zn binding site [ion binding]; other site
101510004707	Domain of unknown function (DUF3358); Region: DUF3358; pfam11838
101510004708	hypothetical protein; Provisional; Region: PRK08244
101510004709	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510004710	Helix-turn-helix domains; Region: HTH; cl00088
101510004711	cyclase homology domain; Region: CHD; cd07302
101510004712	nucleotidyl binding site; other site
101510004713	metal binding site [ion binding]; metal-binding site
101510004714	dimer interface [polypeptide binding]; other site
101510004715	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510004716	Helix-turn-helix domains; Region: HTH; cl00088
101510004717	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
101510004718	CoenzymeA binding site [chemical binding]; other site
101510004719	subunit interaction site [polypeptide binding]; other site
101510004720	PHB binding site; other site
101510004721	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
101510004722	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
101510004723	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
101510004724	catalytic residue [active]
101510004725	Pirin-related protein [General function prediction only]; Region: COG1741
101510004726	Cupin domain; Region: Cupin_2; cl09118
101510004727	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
101510004728	Helix-turn-helix domains; Region: HTH; cl00088
101510004729	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
101510004730	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510004731	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
101510004732	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510004733	putative substrate translocation pore; other site
101510004734	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510004735	Transcriptional regulators [Transcription]; Region: MarR; COG1846
101510004736	Helix-turn-helix domains; Region: HTH; cl00088
101510004737	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
101510004738	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
101510004739	NAD(P) binding site [chemical binding]; other site
101510004740	Ferredoxin [Energy production and conversion]; Region: COG1146
101510004741	Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143
101510004742	4Fe-4S binding domain; Region: Fer4; cl02805
101510004743	ferredoxin-NADP+ reductase; Region: PLN02852
101510004744	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
101510004745	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
101510004746	active site
101510004747	Helix-turn-helix domains; Region: HTH; cl00088
101510004748	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
101510004749	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
101510004750	active site
101510004751	catalytic tetrad [active]
101510004752	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
101510004753	catalytic core [active]
101510004754	Helix-turn-helix domains; Region: HTH; cl00088
101510004755	Peptidase family M23; Region: Peptidase_M23; pfam01551
101510004756	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
101510004757	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
101510004758	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
101510004759	DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597
101510004760	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
101510004761	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
101510004762	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
101510004763	G-loop; other site
101510004764	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
101510004765	DNA binding site [nucleotide binding]
101510004766	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
101510004767	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
101510004768	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
101510004769	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
101510004770	RPB1 interaction site [polypeptide binding]; other site
101510004771	RPB10 interaction site [polypeptide binding]; other site
101510004772	RPB11 interaction site [polypeptide binding]; other site
101510004773	RPB3 interaction site [polypeptide binding]; other site
101510004774	RPB12 interaction site [polypeptide binding]; other site
101510004775	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
101510004776	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
101510004777	mce related protein; Region: MCE; cl15431
101510004778	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
101510004779	mce related protein; Region: MCE; cl15431
101510004780	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
101510004781	mce related protein; Region: MCE; cl15431
101510004782	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
101510004783	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
101510004784	mce related protein; Region: MCE; cl15431
101510004785	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
101510004786	mce related protein; Region: MCE; cl15431
101510004787	mce related protein; Region: MCE; cl15431
101510004788	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
101510004789	Domain of unknown function DUF140; Region: DUF140; cl00510
101510004790	Domain of unknown function DUF140; Region: DUF140; cl00510
101510004791	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
101510004792	ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261
101510004793	Walker A/P-loop; other site
101510004794	ATP binding site [chemical binding]; other site
101510004795	Q-loop/lid; other site
101510004796	ABC transporter signature motif; other site
101510004797	Walker B; other site
101510004798	D-loop; other site
101510004799	H-loop/switch region; other site
101510004800	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
101510004801	core dimer interface [polypeptide binding]; other site
101510004802	peripheral dimer interface [polypeptide binding]; other site
101510004803	L10 interface [polypeptide binding]; other site
101510004804	L11 interface [polypeptide binding]; other site
101510004805	putative EF-Tu interaction site [polypeptide binding]; other site
101510004806	putative EF-G interaction site [polypeptide binding]; other site
101510004807	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
101510004808	23S rRNA interface [nucleotide binding]; other site
101510004809	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
101510004810	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
101510004811	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510004812	putative substrate translocation pore; other site
101510004813	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
101510004814	mRNA/rRNA interface [nucleotide binding]; other site
101510004815	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
101510004816	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
101510004817	23S rRNA interface [nucleotide binding]; other site
101510004818	L7/L12 interface [polypeptide binding]; other site
101510004819	putative thiostrepton binding site; other site
101510004820	L25 interface [polypeptide binding]; other site
101510004821	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
101510004822	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
101510004823	putative homodimer interface [polypeptide binding]; other site
101510004824	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
101510004825	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
101510004826	active site
101510004827	catalytic site [active]
101510004828	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
101510004829	active site
101510004830	catalytic site [active]
101510004831	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
101510004832	Protein of unknown function (DUF520); Region: DUF520; cl00723
101510004833	Peptidase family M48; Region: Peptidase_M48; cl12018
101510004834	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
101510004835	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
101510004836	substrate binding pocket [chemical binding]; other site
101510004837	chain length determination region; other site
101510004838	substrate-Mg2+ binding site; other site
101510004839	catalytic residues [active]
101510004840	aspartate-rich region 1; other site
101510004841	active site lid residues [active]
101510004842	aspartate-rich region 2; other site
101510004843	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
101510004844	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
101510004845	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510004846	S-adenosylmethionine binding site [chemical binding]; other site
101510004847	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510004848	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
101510004849	NAD(P) binding site [chemical binding]; other site
101510004850	catalytic residues [active]
101510004851	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
101510004852	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
101510004853	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
101510004854	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
101510004855	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
101510004856	dimer interface [polypeptide binding]; other site
101510004857	tetramer interface [polypeptide binding]; other site
101510004858	PYR/PP interface [polypeptide binding]; other site
101510004859	TPP binding site [chemical binding]; other site
101510004860	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
101510004861	TPP-binding site; other site
101510004862	Flavin Reductases; Region: FlaRed; cl00801
101510004863	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
101510004864	FAD binding pocket [chemical binding]; other site
101510004865	FAD binding motif [chemical binding]; other site
101510004866	phosphate binding motif [ion binding]; other site
101510004867	NAD binding pocket [chemical binding]; other site
101510004868	O-succinylbenzoate synthase; Provisional; Region: PRK02901
101510004869	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
101510004870	active site
101510004871	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
101510004872	CoenzymeA binding site [chemical binding]; other site
101510004873	subunit interaction site [polypeptide binding]; other site
101510004874	PHB binding site; other site
101510004875	naphthoate synthase; Validated; Region: PRK08321
101510004876	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510004877	substrate binding site [chemical binding]; other site
101510004878	oxyanion hole (OAH) forming residues; other site
101510004879	trimer interface [polypeptide binding]; other site
101510004880	Sulfatase; Region: Sulfatase; cl10460
101510004881	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510004882	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
101510004883	active site
101510004884	Phosphate transporter family; Region: PHO4; cl00396
101510004885	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
101510004886	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
101510004887	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510004888	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
101510004889	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510004890	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
101510004891	Walker A/P-loop; other site
101510004892	ATP binding site [chemical binding]; other site
101510004893	Q-loop/lid; other site
101510004894	ABC transporter signature motif; other site
101510004895	Walker B; other site
101510004896	D-loop; other site
101510004897	H-loop/switch region; other site
101510004898	ABC-2 type transporter; Region: ABC2_membrane; cl11417
101510004899	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
101510004900	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151
101510004901	homotrimer interaction site [polypeptide binding]; other site
101510004902	putative active site [active]
101510004903	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
101510004904	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510004905	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510004906	Amino acid permease; Region: AA_permease; cl00524
101510004907	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510004908	Helix-turn-helix domains; Region: HTH; cl00088
101510004909	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510004910	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510004911	UbiA prenyltransferase family; Region: UbiA; cl00337
101510004912	Membrane protein of unknown function; Region: DUF360; cl00850
101510004913	Clp amino terminal domain; Region: Clp_N; pfam02861
101510004914	Clp amino terminal domain; Region: Clp_N; pfam02861
101510004915	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
101510004916	putative acyl-acceptor binding pocket; other site
101510004917	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
101510004918	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
101510004919	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
101510004920	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
101510004921	catalytic residue [active]
101510004922	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
101510004923	DNA binding residues [nucleotide binding]
101510004924	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
101510004925	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
101510004926	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
101510004927	ResB-like family; Region: ResB; pfam05140
101510004928	LysE type translocator; Region: LysE; cl00565
101510004929	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
101510004930	catalytic residues [active]
101510004931	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
101510004932	catalytic core [active]
101510004933	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
101510004934	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
101510004935	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
101510004936	inhibitor-cofactor binding pocket; inhibition site
101510004937	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510004938	catalytic residue [active]
101510004939	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
101510004940	dimer interface [polypeptide binding]; other site
101510004941	substrate binding site [chemical binding]; other site
101510004942	metal binding site [ion binding]; metal-binding site
101510004943	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510004944	classical (c) SDRs; Region: SDR_c; cd05233
101510004945	NAD(P) binding site [chemical binding]; other site
101510004946	active site
101510004947	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
101510004948	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
101510004949	dimer interface [polypeptide binding]; other site
101510004950	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
101510004951	active site
101510004952	Fe binding site [ion binding]; other site
101510004953	Helix-turn-helix domains; Region: HTH; cl00088
101510004954	Helix-turn-helix domains; Region: HTH; cl00088
101510004955	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510004956	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
101510004957	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510004958	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510004959	active site
101510004960	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
101510004961	dimer interface [polypeptide binding]; other site
101510004962	active site
101510004963	Schiff base residues; other site
101510004964	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
101510004965	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
101510004966	active site
101510004967	Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602
101510004968	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
101510004969	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189
101510004970	domain interfaces; other site
101510004971	active site
101510004972	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
101510004973	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
101510004974	tRNA; other site
101510004975	putative tRNA binding site [nucleotide binding]; other site
101510004976	putative NADP binding site [chemical binding]; other site
101510004977	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
101510004978	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
101510004979	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
101510004980	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510004981	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
101510004982	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
101510004983	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
101510004984	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
101510004985	putative acyl-acceptor binding pocket; other site
101510004986	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
101510004987	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
101510004988	putative NAD(P) binding site [chemical binding]; other site
101510004989	active site
101510004990	putative substrate binding site [chemical binding]; other site
101510004991	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
101510004992	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
101510004993	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510004994	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
101510004995	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
101510004996	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
101510004997	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
101510004998	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
101510004999	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
101510005000	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510005001	active site
101510005002	phosphorylation site [posttranslational modification]
101510005003	intermolecular recognition site; other site
101510005004	dimerization interface [polypeptide binding]; other site
101510005005	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
101510005006	DNA binding site [nucleotide binding]
101510005007	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
101510005008	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
101510005009	dimer interface [polypeptide binding]; other site
101510005010	phosphorylation site [posttranslational modification]
101510005011	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510005012	ATP binding site [chemical binding]; other site
101510005013	Mg2+ binding site [ion binding]; other site
101510005014	G-X-G motif; other site
101510005015	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
101510005016	catalytic core [active]
101510005017	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
101510005018	4-coumarate--CoA ligase; Region: PLN02246
101510005019	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510005020	Protein of unknown function (DUF2596); Region: DUF2596; pfam10770
101510005021	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
101510005022	UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449
101510005023	putative ADP-binding pocket [chemical binding]; other site
101510005024	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510005025	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
101510005026	tocopherol cyclase; Region: PLN02818
101510005027	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
101510005028	catalytic triad [active]
101510005029	conserved cis-peptide bond; other site
101510005030	Protein of unknown function (DUF742); Region: DUF742; pfam05331
101510005031	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
101510005032	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
101510005033	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
101510005034	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510005035	putative substrate translocation pore; other site
101510005036	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
101510005037	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
101510005038	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510005039	NAD(P) binding site [chemical binding]; other site
101510005040	active site
101510005041	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
101510005042	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
101510005043	FAD binding domain; Region: FAD_binding_4; pfam01565
101510005044	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
101510005045	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
101510005046	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
101510005047	TROVE domain; Region: TROVE; pfam05731
101510005048	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425
101510005049	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
101510005050	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
101510005051	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
101510005052	intersubunit interface [polypeptide binding]; other site
101510005053	active site
101510005054	catalytic residue [active]
101510005055	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510005056	S-adenosylmethionine binding site [chemical binding]; other site
101510005057	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
101510005058	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
101510005059	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
101510005060	putative active site [active]
101510005061	putative substrate binding site [chemical binding]; other site
101510005062	putative cosubstrate binding site; other site
101510005063	catalytic site [active]
101510005064	Transcriptional regulators [Transcription]; Region: FadR; COG2186
101510005065	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510005066	DNA-binding site [nucleotide binding]; DNA binding site
101510005067	FCD domain; Region: FCD; cl11656
101510005068	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
101510005069	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510005070	D-galactonate transporter; Region: 2A0114; TIGR00893
101510005071	putative substrate translocation pore; other site
101510005072	Predicted amidohydrolase [General function prediction only]; Region: COG0388
101510005073	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
101510005074	putative active site [active]
101510005075	catalytic triad [active]
101510005076	putative dimer interface [polypeptide binding]; other site
101510005077	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510005078	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510005079	homoserine O-acetyltransferase; Provisional; Region: metX; cl15472
101510005080	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510005081	mercuric resistence transcriptional repressor protein MerD; Region: MerD; TIGR02054
101510005082	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778
101510005083	DNA binding residues [nucleotide binding]
101510005084	putative dimer interface [polypeptide binding]; other site
101510005085	Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
101510005086	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
101510005087	non-specific DNA binding site [nucleotide binding]; other site
101510005088	salt bridge; other site
101510005089	sequence-specific DNA binding site [nucleotide binding]; other site
101510005090	Predicted membrane protein [Function unknown]; Region: COG2733
101510005091	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510005092	Helix-turn-helix domains; Region: HTH; cl00088
101510005093	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
101510005094	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510005095	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
101510005096	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
101510005097	UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449
101510005098	putative ADP-binding pocket [chemical binding]; other site
101510005099	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
101510005100	anti sigma factor interaction site; other site
101510005101	regulatory phosphorylation site [posttranslational modification]; other site
101510005102	ANTAR domain; Region: ANTAR; cl04297
101510005103	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
101510005104	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122
101510005105	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
101510005106	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
101510005107	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
101510005108	DNA binding residues [nucleotide binding]
101510005109	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
101510005110	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
101510005111	putative NAD(P) binding site [chemical binding]; other site
101510005112	putative substrate binding site [chemical binding]; other site
101510005113	catalytic Zn binding site [ion binding]; other site
101510005114	structural Zn binding site [ion binding]; other site
101510005115	dimer interface [polypeptide binding]; other site
101510005116	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
101510005117	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
101510005118	THF binding site; other site
101510005119	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
101510005120	substrate binding site [chemical binding]; other site
101510005121	THF binding site; other site
101510005122	zinc-binding site [ion binding]; other site
101510005123	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
101510005124	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510005125	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
101510005126	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
101510005127	tetramer interface [polypeptide binding]; other site
101510005128	active site
101510005129	Mg2+/Mn2+ binding site [ion binding]; other site
101510005130	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
101510005131	Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023
101510005132	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
101510005133	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
101510005134	non-specific DNA binding site [nucleotide binding]; other site
101510005135	salt bridge; other site
101510005136	sequence-specific DNA binding site [nucleotide binding]; other site
101510005137	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
101510005138	Domain of unknown function (DUF955); Region: DUF955; cl01076
101510005139	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
101510005140	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
101510005141	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
101510005142	putative ligand binding site [chemical binding]; other site
101510005143	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
101510005144	TM-ABC transporter signature motif; other site
101510005145	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
101510005146	TM-ABC transporter signature motif; other site
101510005147	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
101510005148	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
101510005149	Walker A/P-loop; other site
101510005150	ATP binding site [chemical binding]; other site
101510005151	Q-loop/lid; other site
101510005152	ABC transporter signature motif; other site
101510005153	Walker B; other site
101510005154	D-loop; other site
101510005155	H-loop/switch region; other site
101510005156	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
101510005157	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
101510005158	Walker A/P-loop; other site
101510005159	ATP binding site [chemical binding]; other site
101510005160	Q-loop/lid; other site
101510005161	ABC transporter signature motif; other site
101510005162	Walker B; other site
101510005163	D-loop; other site
101510005164	H-loop/switch region; other site
101510005165	Transcriptional regulators [Transcription]; Region: GntR; COG1802
101510005166	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510005167	DNA-binding site [nucleotide binding]; DNA binding site
101510005168	FCD domain; Region: FCD; cl11656
101510005169	classical (c) SDRs; Region: SDR_c; cd05233
101510005170	NAD(P) binding site [chemical binding]; other site
101510005171	active site
101510005172	Uncharacterized conserved protein [Function unknown]; Region: COG2128
101510005173	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
101510005174	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
101510005175	urea carboxylase; Region: urea_carbox; TIGR02712
101510005176	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
101510005177	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
101510005178	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
101510005179	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
101510005180	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
101510005181	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
101510005182	carboxyltransferase (CT) interaction site; other site
101510005183	biotinylation site [posttranslational modification]; other site
101510005184	allophanate hydrolase; Provisional; Region: PRK08186
101510005185	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
101510005186	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
101510005187	NmrA-like family; Region: NmrA; pfam05368
101510005188	NADP binding site [chemical binding]; other site
101510005189	Helix-turn-helix domains; Region: HTH; cl00088
101510005190	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818
101510005191	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510005192	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510005193	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
101510005194	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
101510005195	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510005196	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
101510005197	Predicted esterase [General function prediction only]; Region: COG0627
101510005198	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510005199	PspC domain; Region: PspC; cl00864
101510005200	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
101510005201	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
101510005202	ring oligomerisation interface [polypeptide binding]; other site
101510005203	ATP/Mg binding site [chemical binding]; other site
101510005204	stacking interactions; other site
101510005205	hinge regions; other site
101510005206	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
101510005207	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
101510005208	active site
101510005209	motif I; other site
101510005210	motif II; other site
101510005211	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
101510005212	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
101510005213	Ligand Binding Site [chemical binding]; other site
101510005214	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
101510005215	Ligand Binding Site [chemical binding]; other site
101510005216	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822
101510005217	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
101510005218	putative NAD(P) binding site [chemical binding]; other site
101510005219	putative substrate binding site [chemical binding]; other site
101510005220	catalytic Zn binding site [ion binding]; other site
101510005221	structural Zn binding site [ion binding]; other site
101510005222	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
101510005223	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
101510005224	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510005225	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510005226	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
101510005227	active sites [active]
101510005228	tetramer interface [polypeptide binding]; other site
101510005229	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
101510005230	hydrophobic ligand binding site; other site
101510005231	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
101510005232	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl02940
101510005233	beta-clamp/clamp loader binding surface; other site
101510005234	beta-clamp/translesion DNA polymerase binding surface; other site
101510005235	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
101510005236	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
101510005237	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
101510005238	Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073
101510005239	Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359
101510005240	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
101510005241	Walker A motif; other site
101510005242	ATP binding site [chemical binding]; other site
101510005243	Walker B motif; other site
101510005244	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
101510005245	arginine finger; other site
101510005246	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
101510005247	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
101510005248	Walker A motif; other site
101510005249	ATP binding site [chemical binding]; other site
101510005250	Walker B motif; other site
101510005251	arginine finger; other site
101510005252	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
101510005253	tetramer interface [polypeptide binding]; other site
101510005254	active site
101510005255	Mg2+/Mn2+ binding site [ion binding]; other site
101510005256	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
101510005257	nudix motif; other site
101510005258	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644
101510005259	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
101510005260	Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676
101510005261	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
101510005262	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665
101510005263	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
101510005264	Na+/H+ ion antiporter subunit; Region: MNHE; cl00807
101510005265	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
101510005266	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583
101510005267	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
101510005268	active site
101510005269	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
101510005270	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
101510005271	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
101510005272	E-class dimer interface [polypeptide binding]; other site
101510005273	P-class dimer interface [polypeptide binding]; other site
101510005274	active site
101510005275	Cu2+ binding site [ion binding]; other site
101510005276	Zn2+ binding site [ion binding]; other site
101510005277	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
101510005278	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
101510005279	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
101510005280	active site
101510005281	catalytic residues [active]
101510005282	metal binding site [ion binding]; metal-binding site
101510005283	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
101510005284	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
101510005285	putative phosphate binding site [ion binding]; other site
101510005286	putative catalytic site [active]
101510005287	active site
101510005288	metal binding site A [ion binding]; metal-binding site
101510005289	DNA binding site [nucleotide binding]
101510005290	putative AP binding site [nucleotide binding]; other site
101510005291	putative metal binding site B [ion binding]; other site
101510005292	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
101510005293	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
101510005294	ThiC family; Region: ThiC; cl08031
101510005295	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
101510005296	dimer interface [polypeptide binding]; other site
101510005297	substrate binding site [chemical binding]; other site
101510005298	ATP binding site [chemical binding]; other site
101510005299	cyclase homology domain; Region: CHD; cd07302
101510005300	nucleotidyl binding site; other site
101510005301	metal binding site [ion binding]; metal-binding site
101510005302	dimer interface [polypeptide binding]; other site
101510005303	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
101510005304	PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH.  Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816
101510005305	PA/protease or protease-like domain interface [polypeptide binding]; other site
101510005306	M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876
101510005307	active site
101510005308	metal binding site [ion binding]; metal-binding site
101510005309	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
101510005310	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
101510005311	The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance.  Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis.  The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268
101510005312	Walker A/P-loop; other site
101510005313	ATP binding site [chemical binding]; other site
101510005314	Q-loop/lid; other site
101510005315	ABC transporter signature motif; other site
101510005316	Walker B; other site
101510005317	D-loop; other site
101510005318	H-loop/switch region; other site
101510005319	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
101510005320	ThiS interaction site; other site
101510005321	putative active site [active]
101510005322	tetramer interface [polypeptide binding]; other site
101510005323	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
101510005324	thiS-thiF/thiG interaction site; other site
101510005325	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
101510005326	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510005327	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
101510005328	thiamine phosphate binding site [chemical binding]; other site
101510005329	active site
101510005330	pyrophosphate binding site [ion binding]; other site
101510005331	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
101510005332	nudix motif; other site
101510005333	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
101510005334	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
101510005335	substrate binding pocket [chemical binding]; other site
101510005336	membrane-bound complex binding site; other site
101510005337	hinge residues; other site
101510005338	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510005339	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510005340	active site
101510005341	ATP binding site [chemical binding]; other site
101510005342	substrate binding site [chemical binding]; other site
101510005343	activation loop (A-loop); other site
101510005344	Acetokinase family; Region: Acetate_kinase; cl01029
101510005345	phosphate acetyltransferase; Reviewed; Region: PRK05632
101510005346	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510005347	DRTGG domain; Region: DRTGG; cl12147
101510005348	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
101510005349	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
101510005350	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
101510005351	trimer interface [polypeptide binding]; other site
101510005352	active site
101510005353	substrate binding site [chemical binding]; other site
101510005354	CoA binding site [chemical binding]; other site
101510005355	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
101510005356	glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554
101510005357	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510005358	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
101510005359	Domain of unknown function DUF; Region: DUF202; cl09954
101510005360	Predicted esterase [General function prediction only]; Region: COG0627
101510005361	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510005362	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
101510005363	peptide synthase; Provisional; Region: PRK12316
101510005364	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510005365	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510005366	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
101510005367	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
101510005368	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510005369	peptide synthase; Provisional; Region: PRK12467
101510005370	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510005371	peptide synthase; Provisional; Region: PRK12467
101510005372	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510005373	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510005374	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
101510005375	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510005376	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
101510005377	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
101510005378	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
101510005379	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
101510005380	active site
101510005381	peptide synthase; Provisional; Region: PRK12467
101510005382	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510005383	peptide synthase; Provisional; Region: PRK12467
101510005384	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
101510005385	peptide synthase; Provisional; Region: PRK12467
101510005386	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510005387	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510005388	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510005389	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510005390	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510005391	peptide synthase; Provisional; Region: PRK12467
101510005392	peptide synthase; Provisional; Region: PRK12316
101510005393	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510005394	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510005395	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
101510005396	FkbH-like domain; Region: FkbH; TIGR01686
101510005397	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
101510005398	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
101510005399	Coenzyme A binding pocket [chemical binding]; other site
101510005400	hypothetical protein; Validated; Region: PRK06840
101510005401	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
101510005402	active site
101510005403	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510005404	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
101510005405	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
101510005406	active site
101510005407	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
101510005408	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510005409	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510005410	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
101510005411	Protein of unknown function (DUF1684); Region: DUF1684; cl01327
101510005412	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
101510005413	active site
101510005414	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
101510005415	non-prolyl cis peptide bond; other site
101510005416	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510005417	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
101510005418	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
101510005419	Walker A/P-loop; other site
101510005420	ATP binding site [chemical binding]; other site
101510005421	Q-loop/lid; other site
101510005422	ABC transporter signature motif; other site
101510005423	Walker B; other site
101510005424	D-loop; other site
101510005425	H-loop/switch region; other site
101510005426	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
101510005427	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
101510005428	Walker A/P-loop; other site
101510005429	ATP binding site [chemical binding]; other site
101510005430	Q-loop/lid; other site
101510005431	ABC transporter signature motif; other site
101510005432	Walker B; other site
101510005433	D-loop; other site
101510005434	H-loop/switch region; other site
101510005435	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
101510005436	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
101510005437	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510005438	putative PBP binding loops; other site
101510005439	dimer interface [polypeptide binding]; other site
101510005440	ABC-ATPase subunit interface; other site
101510005441	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
101510005442	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510005443	dimer interface [polypeptide binding]; other site
101510005444	conserved gate region; other site
101510005445	putative PBP binding loops; other site
101510005446	ABC-ATPase subunit interface; other site
101510005447	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
101510005448	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
101510005449	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
101510005450	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
101510005451	active site
101510005452	non-prolyl cis peptide bond; other site
101510005453	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510005454	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
101510005455	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510005456	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
101510005457	Coenzyme A binding pocket [chemical binding]; other site
101510005458	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
101510005459	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
101510005460	substrate binding pocket [chemical binding]; other site
101510005461	membrane-bound complex binding site; other site
101510005462	hinge residues; other site
101510005463	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
101510005464	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
101510005465	Walker A/P-loop; other site
101510005466	ATP binding site [chemical binding]; other site
101510005467	Q-loop/lid; other site
101510005468	ABC transporter signature motif; other site
101510005469	Walker B; other site
101510005470	D-loop; other site
101510005471	H-loop/switch region; other site
101510005472	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
101510005473	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510005474	dimer interface [polypeptide binding]; other site
101510005475	conserved gate region; other site
101510005476	putative PBP binding loops; other site
101510005477	ABC-ATPase subunit interface; other site
101510005478	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
101510005479	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
101510005480	UMP phosphatase; Provisional; Region: PRK10444
101510005481	active site
101510005482	motif I; other site
101510005483	motif II; other site
101510005484	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
101510005485	active site
101510005486	motif I; other site
101510005487	motif II; other site
101510005488	Alpha/beta hydrolase of unknown function (DUF1023); Region: DUF1023; pfam06259
101510005489	O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810
101510005490	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
101510005491	homodimer interface [polypeptide binding]; other site
101510005492	substrate-cofactor binding pocket; other site
101510005493	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510005494	catalytic residue [active]
101510005495	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
101510005496	active site residue [active]
101510005497	ferredoxin-NADP+ reductase; Region: PLN02852
101510005498	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510005499	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510005500	Helix-turn-helix domains; Region: HTH; cl00088
101510005501	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
101510005502	active site
101510005503	Protein of unknown function (DUF456); Region: DUF456; cl01069
101510005504	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
101510005505	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
101510005506	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
101510005507	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
101510005508	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973
101510005509	putative DNA binding site [nucleotide binding]; other site
101510005510	catalytic residue [active]
101510005511	putative H2TH interface [polypeptide binding]; other site
101510005512	putative catalytic residues [active]
101510005513	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
101510005514	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
101510005515	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
101510005516	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
101510005517	dimerization interface [polypeptide binding]; other site
101510005518	active site
101510005519	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
101510005520	folate binding site [chemical binding]; other site
101510005521	NADP+ binding site [chemical binding]; other site
101510005522	Cupin domain; Region: Cupin_2; cl09118
101510005523	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319
101510005524	gating phenylalanine in ion channel; other site
101510005525	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
101510005526	GAF domain; Region: GAF; cl00853
101510005527	GAF domain; Region: GAF; cl00853
101510005528	Histidine kinase; Region: HisKA_3; pfam07730
101510005529	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
101510005530	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
101510005531	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510005532	active site
101510005533	phosphorylation site [posttranslational modification]
101510005534	intermolecular recognition site; other site
101510005535	dimerization interface [polypeptide binding]; other site
101510005536	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510005537	DNA binding residues [nucleotide binding]
101510005538	dimerization interface [polypeptide binding]; other site
101510005539	hypothetical protein; Provisional; Region: PRK14851
101510005540	Fatty acid desaturase; Region: FA_desaturase_2; pfam03405
101510005541	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
101510005542	homodimer interface [polypeptide binding]; other site
101510005543	putative substrate binding pocket [chemical binding]; other site
101510005544	diiron center [ion binding]; other site
101510005545	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
101510005546	Ligand Binding Site [chemical binding]; other site
101510005547	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
101510005548	Ligand Binding Site [chemical binding]; other site
101510005549	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
101510005550	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
101510005551	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
101510005552	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
101510005553	Ligand Binding Site [chemical binding]; other site
101510005554	Rrf2 family protein; Region: rrf2_super; TIGR00738
101510005555	Helix-turn-helix domains; Region: HTH; cl00088
101510005556	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
101510005557	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
101510005558	heme-binding site [chemical binding]; other site
101510005559	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
101510005560	FAD binding pocket [chemical binding]; other site
101510005561	FAD binding motif [chemical binding]; other site
101510005562	phosphate binding motif [ion binding]; other site
101510005563	beta-alpha-beta structure motif; other site
101510005564	NAD binding pocket [chemical binding]; other site
101510005565	Heme binding  pocket [chemical binding]; other site
101510005566	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
101510005567	Peptidase family M23; Region: Peptidase_M23; pfam01551
101510005568	Amino acid permease; Region: AA_permease; cl00524
101510005569	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
101510005570	Dienelactone hydrolase family; Region: DLH; pfam01738
101510005571	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510005572	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
101510005573	active site
101510005574	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
101510005575	RNA/DNA hybrid binding site [nucleotide binding]; other site
101510005576	active site
101510005577	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
101510005578	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
101510005579	minor groove reading motif; other site
101510005580	helix-hairpin-helix signature motif; other site
101510005581	active site
101510005582	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397
101510005583	cobalt transport protein CbiN; Validated; Region: PRK06287
101510005584	Cobalt transport protein; Region: CbiQ; cl00463
101510005585	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
101510005586	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
101510005587	Walker A/P-loop; other site
101510005588	ATP binding site [chemical binding]; other site
101510005589	Q-loop/lid; other site
101510005590	ABC transporter signature motif; other site
101510005591	Walker B; other site
101510005592	D-loop; other site
101510005593	H-loop/switch region; other site
101510005594	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
101510005595	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510005596	S-adenosylmethionine binding site [chemical binding]; other site
101510005597	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
101510005598	CoA-transferase family III; Region: CoA_transf_3; pfam02515
101510005599	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
101510005600	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510005601	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510005602	enoyl-CoA hydratase; Provisional; Region: PRK08252
101510005603	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510005604	substrate binding site [chemical binding]; other site
101510005605	oxyanion hole (OAH) forming residues; other site
101510005606	trimer interface [polypeptide binding]; other site
101510005607	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
101510005608	Helix-turn-helix domains; Region: HTH; cl00088
101510005609	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
101510005610	dimerization interface [polypeptide binding]; other site
101510005611	Transcriptional regulator [Transcription]; Region: LysR; COG0583
101510005612	Helix-turn-helix domains; Region: HTH; cl00088
101510005613	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
101510005614	dimerization interface [polypeptide binding]; other site
101510005615	enoyl-CoA hydratase; Provisional; Region: PRK06688
101510005616	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510005617	substrate binding site [chemical binding]; other site
101510005618	oxyanion hole (OAH) forming residues; other site
101510005619	trimer interface [polypeptide binding]; other site
101510005620	Stress responsive A/B Barrel Domain; Region: Dabb; cl06768
101510005621	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
101510005622	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510005623	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510005624	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
101510005625	NAD(P) binding site [chemical binding]; other site
101510005626	active site
101510005627	acetyl-CoA acetyltransferase; Provisional; Region: PRK06504
101510005628	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
101510005629	dimer interface [polypeptide binding]; other site
101510005630	active site
101510005631	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510005632	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510005633	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510005634	active site
101510005635	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
101510005636	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510005637	S-adenosylmethionine binding site [chemical binding]; other site
101510005638	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
101510005639	sensory histidine kinase CreC; Provisional; Region: PRK11100
101510005640	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
101510005641	dimer interface [polypeptide binding]; other site
101510005642	phosphorylation site [posttranslational modification]
101510005643	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510005644	ATP binding site [chemical binding]; other site
101510005645	Mg2+ binding site [ion binding]; other site
101510005646	G-X-G motif; other site
101510005647	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
101510005648	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510005649	active site
101510005650	phosphorylation site [posttranslational modification]
101510005651	intermolecular recognition site; other site
101510005652	dimerization interface [polypeptide binding]; other site
101510005653	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
101510005654	DNA binding site [nucleotide binding]
101510005655	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
101510005656	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510005657	putative substrate translocation pore; other site
101510005658	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
101510005659	CoA-transferase family III; Region: CoA_transf_3; pfam02515
101510005660	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510005661	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510005662	active site
101510005663	Transcriptional regulators [Transcription]; Region: PurR; COG1609
101510005664	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
101510005665	DNA binding site [nucleotide binding]
101510005666	domain linker motif; other site
101510005667	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_7; cd06285
101510005668	putative dimerization interface [polypeptide binding]; other site
101510005669	putative ligand binding site [chemical binding]; other site
101510005670	acyl-CoA synthetase; Validated; Region: PRK08316
101510005671	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510005672	enoyl-CoA hydratase; Validated; Region: PRK08139
101510005673	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510005674	substrate binding site [chemical binding]; other site
101510005675	oxyanion hole (OAH) forming residues; other site
101510005676	trimer interface [polypeptide binding]; other site
101510005677	fumarylacetoacetase; Region: PLN02856
101510005678	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
101510005679	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
101510005680	Cupin domain; Region: Cupin_2; cl09118
101510005681	Transcriptional regulators [Transcription]; Region: MarR; COG1846
101510005682	Helix-turn-helix domains; Region: HTH; cl00088
101510005683	spermidine synthase; Provisional; Region: PRK03612
101510005684	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510005685	S-adenosylmethionine binding site [chemical binding]; other site
101510005686	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
101510005687	Domain of unknown function (DUF4247); Region: DUF4247; pfam14042
101510005688	Protein of unknown function DUF2617; Region: DUF2617; pfam10936
101510005689	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
101510005690	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
101510005691	Isochorismatase family; Region: Isochorismatase; pfam00857
101510005692	catalytic triad [active]
101510005693	conserved cis-peptide bond; other site
101510005694	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
101510005695	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510005696	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
101510005697	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510005698	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510005699	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
101510005700	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
101510005701	siderophore binding site; other site
101510005702	enterobactin exporter EntS; Provisional; Region: PRK10489
101510005703	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510005704	putative substrate translocation pore; other site
101510005705	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510005706	Protein of unknown function (DUF3533); Region: DUF3533; pfam12051
101510005707	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
101510005708	bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975
101510005709	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444
101510005710	active site
101510005711	DNA binding site [nucleotide binding]
101510005712	catalytic site [active]
101510005713	Transport protein; Region: actII; TIGR00833
101510005714	Transport protein; Region: actII; TIGR00833
101510005715	AlkA N-terminal domain; Region: AlkA_N; cl05528
101510005716	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
101510005717	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
101510005718	minor groove reading motif; other site
101510005719	helix-hairpin-helix signature motif; other site
101510005720	substrate binding pocket [chemical binding]; other site
101510005721	active site
101510005722	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206
101510005723	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206
101510005724	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
101510005725	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
101510005726	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
101510005727	DNA binding site [nucleotide binding]
101510005728	active site
101510005729	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
101510005730	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358
101510005731	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
101510005732	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
101510005733	DNA binding site [nucleotide binding]
101510005734	active site
101510005735	short chain dehydrogenase; Provisional; Region: PRK08251
101510005736	classical (c) SDRs; Region: SDR_c; cd05233
101510005737	NAD(P) binding site [chemical binding]; other site
101510005738	active site
101510005739	Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173
101510005740	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
101510005741	putative active site [active]
101510005742	putative substrate binding site [chemical binding]; other site
101510005743	ATP binding site [chemical binding]; other site
101510005744	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510005745	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
101510005746	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
101510005747	active site
101510005748	Helix-turn-helix domains; Region: HTH; cl00088
101510005749	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
101510005750	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
101510005751	hydrophobic ligand binding site; other site
101510005752	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
101510005753	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
101510005754	NAD(P) binding site [chemical binding]; other site
101510005755	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510005756	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510005757	NAD(P) binding site [chemical binding]; other site
101510005758	active site
101510005759	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510005760	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510005761	active site
101510005762	classical (c) SDRs; Region: SDR_c; cd05233
101510005763	NAD(P) binding site [chemical binding]; other site
101510005764	active site
101510005765	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510005766	Helix-turn-helix domains; Region: HTH; cl00088
101510005767	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
101510005768	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510005769	NAD(P) binding site [chemical binding]; other site
101510005770	active site
101510005771	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510005772	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510005773	active site
101510005774	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510005775	Helix-turn-helix domains; Region: HTH; cl00088
101510005776	Domain of unknown function (DUF1973); Region: DUF1973; pfam09315
101510005777	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
101510005778	active site
101510005779	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
101510005780	EspG family; Region: ESX-1_EspG; pfam14011
101510005781	Domain of unknown function (DUF309); Region: DUF309; cl00667
101510005782	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
101510005783	Cytochrome P450; Region: p450; cl12078
101510005784	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
101510005785	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
101510005786	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
101510005787	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510005788	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
101510005789	Helix-turn-helix domains; Region: HTH; cl00088
101510005790	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510005791	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
101510005792	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
101510005793	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
101510005794	Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265
101510005795	ATP-binding site [chemical binding]; other site
101510005796	Gluconate-6-phosphate binding site [chemical binding]; other site
101510005797	gluconate transporter; Region: gntP; TIGR00791
101510005798	GntP family permease; Region: GntP_permease; cl15264
101510005799	Transcriptional regulators [Transcription]; Region: FadR; COG2186
101510005800	FCD domain; Region: FCD; cl11656
101510005801	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
101510005802	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510005803	putative substrate translocation pore; other site
101510005804	Helix-turn-helix domains; Region: HTH; cl00088
101510005805	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
101510005806	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
101510005807	Entner-Doudoroff aldolase; Region: eda; TIGR01182
101510005808	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
101510005809	active site
101510005810	intersubunit interface [polypeptide binding]; other site
101510005811	catalytic residue [active]
101510005812	Dehydratase family; Region: ILVD_EDD; cl00340
101510005813	6-phosphogluconate dehydratase; Region: edd; TIGR01196
101510005814	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
101510005815	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
101510005816	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
101510005817	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
101510005818	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
101510005819	Muconolactone delta-isomerase; Region: MIase; cl01992
101510005820	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
101510005821	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
101510005822	octamer interface [polypeptide binding]; other site
101510005823	active site
101510005824	catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438
101510005825	chlorocatechol 1,2-dioxygenases (1,2-CCDs) (type II enzymes) are homodimeric intradiol dioxygenases that degrade chlorocatechols via the addition of molecular oxygen and the subsequent cleavage between two adjacent hydroxyl groups. This reaction is part...; Region: 1,2-CCD; cd03462
101510005826	dimer interface [polypeptide binding]; other site
101510005827	active site
101510005828	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
101510005829	Helix-turn-helix domains; Region: HTH; cl00088
101510005830	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510005831	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl01383
101510005832	active site
101510005833	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
101510005834	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
101510005835	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
101510005836	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
101510005837	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
101510005838	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
101510005839	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
101510005840	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510005841	Flavin Reductases; Region: FlaRed; cl00801
101510005842	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310
101510005843	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
101510005844	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
101510005845	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510005846	Cytochrome P450; Region: p450; cl12078
101510005847	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
101510005848	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510005849	catalytic loop [active]
101510005850	iron binding site [ion binding]; other site
101510005851	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
101510005852	FAD binding pocket [chemical binding]; other site
101510005853	FAD binding motif [chemical binding]; other site
101510005854	phosphate binding motif [ion binding]; other site
101510005855	beta-alpha-beta structure motif; other site
101510005856	NAD binding pocket [chemical binding]; other site
101510005857	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
101510005858	Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542
101510005859	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
101510005860	putative alpha subunit interface [polypeptide binding]; other site
101510005861	putative active site [active]
101510005862	putative substrate binding site [chemical binding]; other site
101510005863	Fe binding site [ion binding]; other site
101510005864	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
101510005865	inter-subunit interface; other site
101510005866	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
101510005867	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510005868	catalytic loop [active]
101510005869	iron binding site [ion binding]; other site
101510005870	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
101510005871	FAD binding pocket [chemical binding]; other site
101510005872	FAD binding motif [chemical binding]; other site
101510005873	phosphate binding motif [ion binding]; other site
101510005874	beta-alpha-beta structure motif; other site
101510005875	NAD binding pocket [chemical binding]; other site
101510005876	FCD domain; Region: FCD; cl11656
101510005877	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937
101510005878	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510005879	putative NAD(P) binding site [chemical binding]; other site
101510005880	active site
101510005881	benzoate transport; Region: 2A0115; TIGR00895
101510005882	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510005883	putative substrate translocation pore; other site
101510005884	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510005885	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
101510005886	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
101510005887	TPP-binding site [chemical binding]; other site
101510005888	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
101510005889	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
101510005890	dimer interface [polypeptide binding]; other site
101510005891	PYR/PP interface [polypeptide binding]; other site
101510005892	TPP binding site [chemical binding]; other site
101510005893	substrate binding site [chemical binding]; other site
101510005894	Predicted ATPase [General function prediction only]; Region: COG3899
101510005895	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
101510005896	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510005897	DNA binding residues [nucleotide binding]
101510005898	dimerization interface [polypeptide binding]; other site
101510005899	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510005900	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
101510005901	active site
101510005902	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439
101510005903	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510005904	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
101510005905	peptide synthase; Provisional; Region: PRK12316
101510005906	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510005907	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510005908	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
101510005909	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510005910	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510005911	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510005912	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510005913	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
101510005914	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510005915	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510005916	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
101510005917	aconitate hydratase; Validated; Region: PRK07229
101510005918	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
101510005919	substrate binding site [chemical binding]; other site
101510005920	ligand binding site [chemical binding]; other site
101510005921	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
101510005922	substrate binding site [chemical binding]; other site
101510005923	Mitochondrial ribosomal death-associated protein 3; Region: DAP3; pfam10236
101510005924	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
101510005925	RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648
101510005926	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
101510005927	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
101510005928	DNA binding residues [nucleotide binding]
101510005929	VPS10 domain; Region: VPS10; smart00602
101510005930	Ubiquitin-like proteins; Region: UBQ; cl00155
101510005931	charged pocket; other site
101510005932	hydrophobic patch; other site
101510005933	Putative cyclase; Region: Cyclase; cl00814
101510005934	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510005935	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510005936	active site
101510005937	ATP binding site [chemical binding]; other site
101510005938	substrate binding site [chemical binding]; other site
101510005939	activation loop (A-loop); other site
101510005940	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
101510005941	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510005942	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
101510005943	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
101510005944	Encapsulating protein for peroxidase; Region: Linocin_M18; cl12047
101510005945	CGNR zinc finger; Region: zf-CGNR; pfam11706
101510005946	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
101510005947	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510005948	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
101510005949	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510005950	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
101510005951	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
101510005952	active site
101510005953	dimer interface [polypeptide binding]; other site
101510005954	non-prolyl cis peptide bond; other site
101510005955	insertion regions; other site
101510005956	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510005957	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510005958	putative substrate translocation pore; other site
101510005959	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510005960	Helix-turn-helix domains; Region: HTH; cl00088
101510005961	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510005962	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
101510005963	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
101510005964	active site
101510005965	dimer interface [polypeptide binding]; other site
101510005966	non-prolyl cis peptide bond; other site
101510005967	insertion regions; other site
101510005968	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
101510005969	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510005970	active site
101510005971	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
101510005972	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510005973	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510005974	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510005975	putative substrate translocation pore; other site
101510005976	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
101510005977	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
101510005978	dimerization interface [polypeptide binding]; other site
101510005979	putative DNA binding site [nucleotide binding]; other site
101510005980	putative Zn2+ binding site [ion binding]; other site
101510005981	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
101510005982	diiron binding motif [ion binding]; other site
101510005983	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
101510005984	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
101510005985	putative active site [active]
101510005986	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
101510005987	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510005988	Helix-turn-helix domains; Region: HTH; cl00088
101510005989	Fusaric acid resistance protein-like; Region: FUSC_2; cl15844
101510005990	Helix-turn-helix domains; Region: HTH; cl00088
101510005991	progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948
101510005992	NAD(P) binding site [chemical binding]; other site
101510005993	active site
101510005994	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
101510005995	dimerization interface [polypeptide binding]; other site
101510005996	putative DNA binding site [nucleotide binding]; other site
101510005997	putative Zn2+ binding site [ion binding]; other site
101510005998	Protein of unknown function DUF72; Region: DUF72; cl00777
101510005999	GYD domain; Region: GYD; cl01743
101510006000	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510006001	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
101510006002	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691
101510006003	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
101510006004	putative metal binding site [ion binding]; other site
101510006005	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
101510006006	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
101510006007	putative metal binding site [ion binding]; other site
101510006008	Tellurium resistance protein; Region: Tellurium_res; pfam10138
101510006009	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
101510006010	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
101510006011	putative metal binding site [ion binding]; other site
101510006012	Protein of unknown function (DUF2983); Region: DUF2983; pfam11202
101510006013	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
101510006014	Protein of unknown function (DUF3706); Region: DUF3706; pfam12500
101510006015	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
101510006016	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
101510006017	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
101510006018	putative metal binding site [ion binding]; other site
101510006019	Integral membrane protein TerC family; Region: TerC; cl10468
101510006020	Protein of unknown function DUF124; Region: DUF124; cl00884
101510006021	Protein of unknown function DUF124; Region: DUF124; cl00884
101510006022	Protein of unknown function DUF124; Region: DUF124; cl00884
101510006023	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
101510006024	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510006025	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
101510006026	homotrimer interaction site [polypeptide binding]; other site
101510006027	putative active site [active]
101510006028	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510006029	Helix-turn-helix domains; Region: HTH; cl00088
101510006030	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510006031	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
101510006032	substrate binding site [chemical binding]; other site
101510006033	ATP binding site [chemical binding]; other site
101510006034	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
101510006035	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818
101510006036	dimer interface [polypeptide binding]; other site
101510006037	active site
101510006038	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
101510006039	substrate binding site [chemical binding]; other site
101510006040	catalytic residue [active]
101510006041	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
101510006042	active site
101510006043	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
101510006044	putative substrate binding pocket [chemical binding]; other site
101510006045	active site
101510006046	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
101510006047	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
101510006048	Entner-Doudoroff aldolase; Region: eda; TIGR01182
101510006049	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
101510006050	active site
101510006051	intersubunit interface [polypeptide binding]; other site
101510006052	catalytic residue [active]
101510006053	gluconate transporter; Region: gntP; TIGR00791
101510006054	GntP family permease; Region: GntP_permease; cl15264
101510006055	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510006056	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
101510006057	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
101510006058	N-acetyltransferase; Region: Acetyltransf_2; cl00949
101510006059	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
101510006060	Helix-turn-helix domains; Region: HTH; cl00088
101510006061	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510006062	shikimate 5-dehydrogenase; Reviewed; Region: PRK12549
101510006063	shikimate transporter; Provisional; Region: PRK09952
101510006064	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510006065	putative substrate translocation pore; other site
101510006066	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
101510006067	Amino acid permease; Region: AA_permease; cl00524
101510006068	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
101510006069	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510006070	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
101510006071	Phosphoesterase family; Region: Phosphoesterase; cl15450
101510006072	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
101510006073	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
101510006074	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
101510006075	classical (c) SDRs; Region: SDR_c; cd05233
101510006076	NAD(P) binding site [chemical binding]; other site
101510006077	active site
101510006078	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510006079	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
101510006080	classical (c) SDRs; Region: SDR_c; cd05233
101510006081	NAD(P) binding site [chemical binding]; other site
101510006082	active site
101510006083	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
101510006084	classical (c) SDRs; Region: SDR_c; cd05233
101510006085	NAD(P) binding site [chemical binding]; other site
101510006086	active site
101510006087	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835
101510006088	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510006089	Flavin Reductases; Region: FlaRed; cl00801
101510006090	Helix-turn-helix domains; Region: HTH; cl00088
101510006091	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
101510006092	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510006093	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510006094	Helix-turn-helix domains; Region: HTH; cl00088
101510006095	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510006096	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
101510006097	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
101510006098	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
101510006099	active site
101510006100	Fe binding site [ion binding]; other site
101510006101	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510006102	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510006103	active site
101510006104	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
101510006105	The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH).  The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531
101510006106	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
101510006107	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
101510006108	peptide synthase; Provisional; Region: PRK12467
101510006109	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510006110	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510006111	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
101510006112	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510006113	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510006114	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
101510006115	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
101510006116	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
101510006117	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
101510006118	NAD binding site [chemical binding]; other site
101510006119	catalytic Zn binding site [ion binding]; other site
101510006120	substrate binding site [chemical binding]; other site
101510006121	structural Zn binding site [ion binding]; other site
101510006122	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
101510006123	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510006124	NAD(P) binding site [chemical binding]; other site
101510006125	catalytic residues [active]
101510006126	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
101510006127	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
101510006128	Helix-turn-helix domains; Region: HTH; cl00088
101510006129	Secretory lipase; Region: LIP; pfam03583
101510006130	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510006131	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510006132	putative substrate translocation pore; other site
101510006133	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
101510006134	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
101510006135	metal binding site [ion binding]; metal-binding site
101510006136	dimer interface [polypeptide binding]; other site
101510006137	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
101510006138	Helix-turn-helix domains; Region: HTH; cl00088
101510006139	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
101510006140	Helix-turn-helix domains; Region: HTH; cl00088
101510006141	Helix-turn-helix domains; Region: HTH; cl00088
101510006142	DinB superfamily; Region: DinB_2; cl00986
101510006143	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510006144	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
101510006145	ANTAR domain; Region: ANTAR; cl04297
101510006146	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
101510006147	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
101510006148	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510006149	Cytochrome P450; Region: p450; cl12078
101510006150	Domain of unknown function DUF222; Region: DUF222; pfam02720
101510006151	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
101510006152	active site
101510006153	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510006154	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
101510006155	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510006156	Flavin Reductases; Region: FlaRed; cl00801
101510006157	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310
101510006158	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
101510006159	catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438
101510006160	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl01383
101510006161	active site
101510006162	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510006163	acetyl-CoA acetyltransferase; Provisional; Region: PRK06205
101510006164	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
101510006165	dimer interface [polypeptide binding]; other site
101510006166	active site
101510006167	acyl-CoA synthetase; Validated; Region: PRK06164
101510006168	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510006169	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510006170	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510006171	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510006172	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510006173	active site
101510006174	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510006175	Helix-turn-helix domains; Region: HTH; cl00088
101510006176	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
101510006177	Protein of unknown function, DUF485; Region: DUF485; cl01231
101510006178	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
101510006179	Sodium:solute symporter family; Region: SSF; cl00456
101510006180	Protein of unknown function (DUF1348); Region: DUF1348; pfam07080
101510006181	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510006182	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510006183	Helix-turn-helix domains; Region: HTH; cl00088
101510006184	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
101510006185	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
101510006186	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
101510006187	motif II; other site
101510006188	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
101510006189	Queuine tRNA-ribosyltransferase; Region: TGT; cl00409
101510006190	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691
101510006191	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
101510006192	Fatty acid desaturase; Region: FA_desaturase; pfam00487
101510006193	Di-iron ligands [ion binding]; other site
101510006194	Rubredoxin [Energy production and conversion]; Region: COG1773
101510006195	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
101510006196	iron binding site [ion binding]; other site
101510006197	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
101510006198	Rubredoxin; Region: Rubredoxin; pfam00301
101510006199	iron binding site [ion binding]; other site
101510006200	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
101510006201	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510006202	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510006203	Helix-turn-helix domains; Region: HTH; cl00088
101510006204	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
101510006205	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510006206	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510006207	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510006208	Helix-turn-helix domains; Region: HTH; cl00088
101510006209	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510006210	OpgC protein; Region: OpgC_C; cl00792
101510006211	benzoate transport; Region: 2A0115; TIGR00895
101510006212	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
101510006213	dimer interface [polypeptide binding]; other site
101510006214	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510006215	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
101510006216	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
101510006217	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235
101510006218	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
101510006219	ABC-ATPase subunit  interface; other site
101510006220	dimer interface [polypeptide binding]; other site
101510006221	putative PBP binding regions; other site
101510006222	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
101510006223	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
101510006224	intersubunit interface [polypeptide binding]; other site
101510006225	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
101510006226	Protein of unknown function (DUF419); Region: DUF419; cl15265
101510006227	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
101510006228	putative hydrophobic ligand binding site [chemical binding]; other site
101510006229	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510006230	TIGR01777 family protein; Region: yfcH
101510006231	NAD(P) binding site [chemical binding]; other site
101510006232	active site
101510006233	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
101510006234	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
101510006235	putative NAD(P) binding site [chemical binding]; other site
101510006236	putative active site [active]
101510006237	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
101510006238	Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150
101510006239	Fasciclin domain; Region: Fasciclin; cl02663
101510006240	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
101510006241	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
101510006242	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510006243	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
101510006244	Uncharacterized conserved protein [Function unknown]; Region: COG3496
101510006245	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
101510006246	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510006247	S-adenosylmethionine binding site [chemical binding]; other site
101510006248	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
101510006249	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510006250	S-adenosylmethionine binding site [chemical binding]; other site
101510006251	Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763
101510006252	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
101510006253	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
101510006254	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
101510006255	DNA binding residues [nucleotide binding]
101510006256	Anti-sigma-K factor rskA; Region: RskA; cl15366
101510006257	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
101510006258	active site
101510006259	pyruvate kinase; Provisional; Region: PRK06247
101510006260	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
101510006261	domain interfaces; other site
101510006262	active site
101510006263	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
101510006264	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
101510006265	dimer interface [polypeptide binding]; other site
101510006266	TPP-binding site [chemical binding]; other site
101510006267	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
101510006268	Sodium:solute symporter family; Region: SSF; cl00456
101510006269	Probable transposase; Region: OrfB_IS605; pfam01385
101510006270	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
101510006271	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
101510006272	Malic enzyme, N-terminal domain; Region: malic; pfam00390
101510006273	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
101510006274	putative NAD(P) binding site [chemical binding]; other site
101510006275	allantoicase; Provisional; Region: PRK13257
101510006276	Allantoicase repeat; Region: Allantoicase; pfam03561
101510006277	Allantoicase repeat; Region: Allantoicase; pfam03561
101510006278	Glycerate kinase family; Region: Gly_kinase; cl00841
101510006279	glyoxylate carboligase; Provisional; Region: PRK11269
101510006280	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
101510006281	PYR/PP interface [polypeptide binding]; other site
101510006282	dimer interface [polypeptide binding]; other site
101510006283	TPP binding site [chemical binding]; other site
101510006284	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
101510006285	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
101510006286	TPP-binding site [chemical binding]; other site
101510006287	2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505
101510006288	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510006289	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
101510006290	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
101510006291	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
101510006292	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
101510006293	Helix-turn-helix domains; Region: HTH; cl00088
101510006294	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510006295	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510006296	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510006297	active site
101510006298	ATP binding site [chemical binding]; other site
101510006299	substrate binding site [chemical binding]; other site
101510006300	activation loop (A-loop); other site
101510006301	Clp amino terminal domain; Region: Clp_N; pfam02861
101510006302	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510006303	DNA binding residues [nucleotide binding]
101510006304	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
101510006305	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
101510006306	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
101510006307	putative molybdopterin cofactor binding site [chemical binding]; other site
101510006308	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
101510006309	putative molybdopterin cofactor binding site; other site
101510006310	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510006311	mycothiol-dependent formaldehyde dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
101510006312	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
101510006313	NAD binding site [chemical binding]; other site
101510006314	catalytic Zn binding site [ion binding]; other site
101510006315	substrate binding site [chemical binding]; other site
101510006316	structural Zn binding site [ion binding]; other site
101510006317	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
101510006318	active sites [active]
101510006319	tetramer interface [polypeptide binding]; other site
101510006320	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
101510006321	OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment.  ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295
101510006322	Walker A/P-loop; other site
101510006323	ATP binding site [chemical binding]; other site
101510006324	Q-loop/lid; other site
101510006325	ABC transporter signature motif; other site
101510006326	Walker B; other site
101510006327	D-loop; other site
101510006328	H-loop/switch region; other site
101510006329	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510006330	dimer interface [polypeptide binding]; other site
101510006331	conserved gate region; other site
101510006332	ABC-ATPase subunit interface; other site
101510006333	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
101510006334	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
101510006335	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
101510006336	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
101510006337	nucleoside/Zn binding site; other site
101510006338	dimer interface [polypeptide binding]; other site
101510006339	catalytic motif [active]
101510006340	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
101510006341	Sulfatase; Region: Sulfatase; cl10460
101510006342	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
101510006343	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510006344	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
101510006345	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510006346	DNA-binding site [nucleotide binding]; DNA binding site
101510006347	FCD domain; Region: FCD; cl11656
101510006348	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
101510006349	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
101510006350	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510006351	NAD(P) binding site [chemical binding]; other site
101510006352	active site
101510006353	Uncharacterized conserved protein [Function unknown]; Region: COG3595
101510006354	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510006355	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
101510006356	Walker A/P-loop; other site
101510006357	ATP binding site [chemical binding]; other site
101510006358	Q-loop/lid; other site
101510006359	ABC transporter signature motif; other site
101510006360	Walker B; other site
101510006361	D-loop; other site
101510006362	H-loop/switch region; other site
101510006363	ABC-2 type transporter; Region: ABC2_membrane; cl11417
101510006364	Cytochrome P450; Region: p450; cl12078
101510006365	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510006366	Protein of unknown function (DUF1749); Region: DUF1749; pfam08538
101510006367	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
101510006368	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
101510006369	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510006370	tyramine oxidase; Provisional; Region: tynA; PRK11504
101510006371	Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727
101510006372	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
101510006373	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
101510006374	Amino acid permease; Region: AA_permease; cl00524
101510006375	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
101510006376	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510006377	NAD(P) binding site [chemical binding]; other site
101510006378	catalytic residues [active]
101510006379	Amino acid permease; Region: AA_permease; cl00524
101510006380	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510006381	Helix-turn-helix domains; Region: HTH; cl00088
101510006382	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510006383	short chain dehydrogenase; Provisional; Region: PRK07825
101510006384	classical (c) SDRs; Region: SDR_c; cd05233
101510006385	NAD(P) binding site [chemical binding]; other site
101510006386	active site
101510006387	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
101510006388	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
101510006389	active site
101510006390	non-prolyl cis peptide bond; other site
101510006391	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
101510006392	active site
101510006393	catalytic triad [active]
101510006394	oxyanion hole [active]
101510006395	Transcription factor WhiB; Region: Whib; pfam02467
101510006396	Helix-turn-helix domains; Region: HTH; cl00088
101510006397	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
101510006398	active site
101510006399	catalytic residues [active]
101510006400	metal binding site [ion binding]; metal-binding site
101510006401	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
101510006402	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510006403	active site
101510006404	phosphorylation site [posttranslational modification]
101510006405	intermolecular recognition site; other site
101510006406	dimerization interface [polypeptide binding]; other site
101510006407	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510006408	DNA binding residues [nucleotide binding]
101510006409	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510006410	Response regulator receiver domain; Region: Response_reg; pfam00072
101510006411	active site
101510006412	phosphorylation site [posttranslational modification]
101510006413	intermolecular recognition site; other site
101510006414	dimerization interface [polypeptide binding]; other site
101510006415	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
101510006416	Histidine kinase; Region: HisKA_3; pfam07730
101510006417	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
101510006418	Helix-turn-helix domains; Region: HTH; cl00088
101510006419	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510006420	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510006421	active site
101510006422	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510006423	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
101510006424	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510006425	classical (c) SDRs; Region: SDR_c; cd05233
101510006426	NAD(P) binding site [chemical binding]; other site
101510006427	active site
101510006428	dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396
101510006429	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510006430	substrate binding site [chemical binding]; other site
101510006431	oxyanion hole (OAH) forming residues; other site
101510006432	trimer interface [polypeptide binding]; other site
101510006433	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510006434	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510006435	active site
101510006436	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510006437	Helix-turn-helix domains; Region: HTH; cl00088
101510006438	DinB superfamily; Region: DinB_2; cl00986
101510006439	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
101510006440	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510006441	Helix-turn-helix domains; Region: HTH; cl00088
101510006442	Domain of unknown function (DUF385); Region: DUF385; cl04387
101510006443	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510006444	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691
101510006445	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
101510006446	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
101510006447	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510006448	NAD binding site [chemical binding]; other site
101510006449	catalytic residues [active]
101510006450	Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
101510006451	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
101510006452	catalytic Zn binding site [ion binding]; other site
101510006453	NAD binding site [chemical binding]; other site
101510006454	structural Zn binding site [ion binding]; other site
101510006455	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
101510006456	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
101510006457	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
101510006458	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510006459	Cytochrome P450; Region: p450; cl12078
101510006460	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
101510006461	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
101510006462	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
101510006463	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510006464	putative oxidoreductase; Provisional; Region: PRK08275
101510006465	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
101510006466	active site
101510006467	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
101510006468	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
101510006469	DUF35 OB-fold domain; Region: DUF35; pfam01796
101510006470	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510006471	Helix-turn-helix domains; Region: HTH; cl00088
101510006472	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510006473	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
101510006474	SCP-2 sterol transfer family; Region: SCP2; cl01225
101510006475	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
101510006476	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510006477	NAD binding site [chemical binding]; other site
101510006478	catalytic residues [active]
101510006479	Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
101510006480	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
101510006481	catalytic Zn binding site [ion binding]; other site
101510006482	NAD binding site [chemical binding]; other site
101510006483	structural Zn binding site [ion binding]; other site
101510006484	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510006485	Secretory lipase; Region: LIP; pfam03583
101510006486	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
101510006487	classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944
101510006488	homodimer interface [polypeptide binding]; other site
101510006489	putative NAD(P) binding site [chemical binding]; other site
101510006490	active site
101510006491	enoyl-CoA hydratase; Provisional; Region: PRK09245
101510006492	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510006493	substrate binding site [chemical binding]; other site
101510006494	oxyanion hole (OAH) forming residues; other site
101510006495	trimer interface [polypeptide binding]; other site
101510006496	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
101510006497	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510006498	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510006499	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
101510006500	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
101510006501	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510006502	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
101510006503	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510006504	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510006505	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
101510006506	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510006507	DNA binding residues [nucleotide binding]
101510006508	dimerization interface [polypeptide binding]; other site
101510006509	Excalibur calcium-binding domain; Region: Excalibur; cl05460
101510006510	Old yellow enzyme (OYE)-related FMN binding domain, group 5.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747
101510006511	putative active site [active]
101510006512	putative FMN binding site [chemical binding]; other site
101510006513	putative substrate binding site [chemical binding]; other site
101510006514	putative catalytic residue [active]
101510006515	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510006516	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510006517	putative substrate translocation pore; other site
101510006518	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510006519	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
101510006520	tetramerization interface [polypeptide binding]; other site
101510006521	NAD(P) binding site [chemical binding]; other site
101510006522	catalytic residues [active]
101510006523	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
101510006524	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614
101510006525	NAD(P) binding site [chemical binding]; other site
101510006526	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510006527	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510006528	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
101510006529	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
101510006530	FMN binding site [chemical binding]; other site
101510006531	substrate binding site [chemical binding]; other site
101510006532	putative catalytic residue [active]
101510006533	enoyl-CoA hydratase; Provisional; Region: PRK08260
101510006534	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510006535	substrate binding site [chemical binding]; other site
101510006536	oxyanion hole (OAH) forming residues; other site
101510006537	trimer interface [polypeptide binding]; other site
101510006538	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510006539	Helix-turn-helix domains; Region: HTH; cl00088
101510006540	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510006541	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510006542	Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173
101510006543	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
101510006544	putative active site [active]
101510006545	putative substrate binding site [chemical binding]; other site
101510006546	ATP binding site [chemical binding]; other site
101510006547	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
101510006548	classical (c) SDRs; Region: SDR_c; cd05233
101510006549	NAD(P) binding site [chemical binding]; other site
101510006550	active site
101510006551	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510006552	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510006553	active site
101510006554	enoyl-CoA hydratase; Provisional; Region: PRK06210
101510006555	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510006556	substrate binding site [chemical binding]; other site
101510006557	oxyanion hole (OAH) forming residues; other site
101510006558	trimer interface [polypeptide binding]; other site
101510006559	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
101510006560	classical (c) SDRs; Region: SDR_c; cd05233
101510006561	NAD(P) binding site [chemical binding]; other site
101510006562	active site
101510006563	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
101510006564	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510006565	DNA-binding site [nucleotide binding]; DNA binding site
101510006566	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510006567	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510006568	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510006569	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
101510006570	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510006571	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510006572	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510006573	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
101510006574	enoyl-CoA hydratase; Provisional; Region: PRK08260
101510006575	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510006576	substrate binding site [chemical binding]; other site
101510006577	oxyanion hole (OAH) forming residues; other site
101510006578	trimer interface [polypeptide binding]; other site
101510006579	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
101510006580	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510006581	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510006582	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
101510006583	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510006584	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510006585	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510006586	Helix-turn-helix domains; Region: HTH; cl00088
101510006587	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510006588	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510006589	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510006590	active site
101510006591	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510006592	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510006593	active site
101510006594	ATP binding site [chemical binding]; other site
101510006595	substrate binding site [chemical binding]; other site
101510006596	activation loop (A-loop); other site
101510006597	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510006598	TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903
101510006599	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510006600	DNA binding residues [nucleotide binding]
101510006601	dimerization interface [polypeptide binding]; other site
101510006602	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510006603	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
101510006604	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
101510006605	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
101510006606	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
101510006607	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510006608	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
101510006609	Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173
101510006610	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
101510006611	putative active site [active]
101510006612	putative substrate binding site [chemical binding]; other site
101510006613	ATP binding site [chemical binding]; other site
101510006614	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
101510006615	putative active site [active]
101510006616	putative catalytic site [active]
101510006617	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510006618	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510006619	NAD(P) binding site [chemical binding]; other site
101510006620	active site
101510006621	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
101510006622	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
101510006623	motif II; other site
101510006624	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
101510006625	classical (c) SDRs; Region: SDR_c; cd05233
101510006626	NAD(P) binding site [chemical binding]; other site
101510006627	active site
101510006628	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
101510006629	active site
101510006630	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
101510006631	active site
101510006632	metal binding site [ion binding]; metal-binding site
101510006633	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510006634	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510006635	DNA binding residues [nucleotide binding]
101510006636	dimerization interface [polypeptide binding]; other site
101510006637	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
101510006638	Prostaglandin dehydrogenases; Region: PGDH; cd05288
101510006639	NAD(P) binding site [chemical binding]; other site
101510006640	substrate binding site [chemical binding]; other site
101510006641	dimer interface [polypeptide binding]; other site
101510006642	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510006643	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510006644	Helix-turn-helix domains; Region: HTH; cl00088
101510006645	acetyl-CoA acetyltransferase; Provisional; Region: PRK07851
101510006646	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
101510006647	dimer interface [polypeptide binding]; other site
101510006648	active site
101510006649	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510006650	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510006651	NAD(P) binding site [chemical binding]; other site
101510006652	active site
101510006653	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
101510006654	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
101510006655	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510006656	active site
101510006657	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
101510006658	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
101510006659	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510006660	NAD(P) binding site [chemical binding]; other site
101510006661	active site
101510006662	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
101510006663	putative active site [active]
101510006664	putative catalytic site [active]
101510006665	Sodium:solute symporter family; Region: SSF; cl00456
101510006666	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
101510006667	active site
101510006668	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
101510006669	N-acetyl-D-glucosamine binding site [chemical binding]; other site
101510006670	catalytic residue [active]
101510006671	NlpC/P60 family; Region: NLPC_P60; cl11438
101510006672	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
101510006673	ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261
101510006674	Walker A/P-loop; other site
101510006675	ATP binding site [chemical binding]; other site
101510006676	Q-loop/lid; other site
101510006677	ABC transporter signature motif; other site
101510006678	Walker B; other site
101510006679	D-loop; other site
101510006680	H-loop/switch region; other site
101510006681	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
101510006682	mce related protein; Region: MCE; cl15431
101510006683	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
101510006684	mce related protein; Region: MCE; cl15431
101510006685	mce related protein; Region: MCE; cl15431
101510006686	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
101510006687	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
101510006688	mce related protein; Region: MCE; cl15431
101510006689	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
101510006690	mce related protein; Region: MCE; cl15431
101510006691	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
101510006692	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
101510006693	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
101510006694	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510006695	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510006696	active site
101510006697	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510006698	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
101510006699	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
101510006700	Transposase; Region: DEDD_Tnp_IS110; pfam01548
101510006701	Integrase core domain; Region: rve; cl01316
101510006702	Helix-turn-helix domains; Region: HTH; cl00088
101510006703	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
101510006704	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
101510006705	Transposase; Region: DDE_Tnp_ISL3; pfam01610
101510006706	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
101510006707	Clp protease ATP binding subunit; Region: clpC; CHL00095
101510006708	Clp amino terminal domain; Region: Clp_N; pfam02861
101510006709	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
101510006710	homoserine O-acetyltransferase; Provisional; Region: metX; cl15472
101510006711	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510006712	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
101510006713	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510006714	DNA binding residues [nucleotide binding]
101510006715	dimerization interface [polypeptide binding]; other site
101510006716	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
101510006717	Integrase core domain; Region: rve; cl01316
101510006718	Cytochrome P450; Region: p450; cl12078
101510006719	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510006720	Helix-turn-helix domains; Region: HTH; cl00088
101510006721	acyl-CoA synthetase; Validated; Region: PRK06178
101510006722	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510006723	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
101510006724	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
101510006725	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
101510006726	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
101510006727	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
101510006728	carboxyltransferase (CT) interaction site; other site
101510006729	biotinylation site [posttranslational modification]; other site
101510006730	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
101510006731	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780
101510006732	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
101510006733	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
101510006734	NADP binding site [chemical binding]; other site
101510006735	dimer interface [polypeptide binding]; other site
101510006736	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
101510006737	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
101510006738	putative NAD(P) binding site [chemical binding]; other site
101510006739	catalytic Zn binding site [ion binding]; other site
101510006740	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
101510006741	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
101510006742	substrate binding site [chemical binding]; other site
101510006743	ATP binding site [chemical binding]; other site
101510006744	Entner-Doudoroff aldolase; Region: eda; TIGR01182
101510006745	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
101510006746	active site
101510006747	intersubunit interface [polypeptide binding]; other site
101510006748	catalytic residue [active]
101510006749	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510006750	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510006751	putative substrate translocation pore; other site
101510006752	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
101510006753	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
101510006754	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
101510006755	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
101510006756	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
101510006757	metal binding site [ion binding]; metal-binding site
101510006758	substrate binding pocket [chemical binding]; other site
101510006759	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
101510006760	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510006761	Transcriptional regulators [Transcription]; Region: PurR; COG1609
101510006762	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
101510006763	DNA binding site [nucleotide binding]
101510006764	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
101510006765	ligand binding site [chemical binding]; other site
101510006766	dimerization interface [polypeptide binding]; other site
101510006767	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
101510006768	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510006769	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510006770	Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575
101510006771	active site
101510006772	dimer interface [polypeptide binding]; other site
101510006773	Transcriptional regulator [Transcription]; Region: LysR; COG0583
101510006774	Helix-turn-helix domains; Region: HTH; cl00088
101510006775	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
101510006776	substrate binding pocket [chemical binding]; other site
101510006777	dimerization interface [polypeptide binding]; other site
101510006778	benzoylformate decarboxylase; Reviewed; Region: PRK07092
101510006779	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
101510006780	PYR/PP interface [polypeptide binding]; other site
101510006781	dimer interface [polypeptide binding]; other site
101510006782	TPP binding site [chemical binding]; other site
101510006783	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
101510006784	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
101510006785	TPP-binding site [chemical binding]; other site
101510006786	dimer interface [polypeptide binding]; other site
101510006787	benzoate transport; Region: 2A0115; TIGR00895
101510006788	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510006789	putative substrate translocation pore; other site
101510006790	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510006791	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510006792	NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152
101510006793	NAD(P) binding site [chemical binding]; other site
101510006794	catalytic residues [active]
101510006795	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
101510006796	apolar tunnel; other site
101510006797	heme binding site [chemical binding]; other site
101510006798	dimerization interface [polypeptide binding]; other site
101510006799	Helix-turn-helix domains; Region: HTH; cl00088
101510006800	Major Facilitator Superfamily; Region: MFS_1; pfam07690
101510006801	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510006802	putative substrate translocation pore; other site
101510006803	Helix-turn-helix domains; Region: HTH; cl00088
101510006804	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
101510006805	FAD binding domain; Region: FAD_binding_4; pfam01565
101510006806	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
101510006807	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510006808	Walker A/P-loop; other site
101510006809	ATP binding site [chemical binding]; other site
101510006810	Q-loop/lid; other site
101510006811	ABC transporter signature motif; other site
101510006812	Walker B; other site
101510006813	D-loop; other site
101510006814	H-loop/switch region; other site
101510006815	TOBE domain; Region: TOBE_2; cl01440
101510006816	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
101510006817	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510006818	dimer interface [polypeptide binding]; other site
101510006819	conserved gate region; other site
101510006820	putative PBP binding loops; other site
101510006821	ABC-ATPase subunit interface; other site
101510006822	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510006823	dimer interface [polypeptide binding]; other site
101510006824	conserved gate region; other site
101510006825	putative PBP binding loops; other site
101510006826	ABC-ATPase subunit interface; other site
101510006827	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
101510006828	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
101510006829	Helix-turn-helix domains; Region: HTH; cl00088
101510006830	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
101510006831	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
101510006832	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
101510006833	inhibitor binding site; inhibition site
101510006834	catalytic Zn binding site [ion binding]; other site
101510006835	structural Zn binding site [ion binding]; other site
101510006836	NADP binding site [chemical binding]; other site
101510006837	tetramer interface [polypeptide binding]; other site
101510006838	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
101510006839	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
101510006840	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
101510006841	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
101510006842	putative substrate binding site [chemical binding]; other site
101510006843	putative ATP binding site [chemical binding]; other site
101510006844	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
101510006845	N- and C-terminal domain interface [polypeptide binding]; other site
101510006846	D-xylulose kinase; Region: XylB; TIGR01312
101510006847	active site
101510006848	MgATP binding site [chemical binding]; other site
101510006849	catalytic site [active]
101510006850	metal binding site [ion binding]; metal-binding site
101510006851	carbohydrate binding site [chemical binding]; other site
101510006852	Prostaglandin dehydrogenases; Region: PGDH; cd05288
101510006853	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
101510006854	NAD(P) binding site [chemical binding]; other site
101510006855	substrate binding site [chemical binding]; other site
101510006856	dimer interface [polypeptide binding]; other site
101510006857	Protein of unknown function (DUF1304); Region: DUF1304; cl01533
101510006858	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510006859	Helix-turn-helix domains; Region: HTH; cl00088
101510006860	allantoate amidohydrolase; Reviewed; Region: PRK09290
101510006861	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
101510006862	active site
101510006863	metal binding site [ion binding]; metal-binding site
101510006864	dimer interface [polypeptide binding]; other site
101510006865	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
101510006866	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
101510006867	active site
101510006868	FMN binding site [chemical binding]; other site
101510006869	substrate binding site [chemical binding]; other site
101510006870	3Fe-4S cluster binding site [ion binding]; other site
101510006871	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
101510006872	domain_subunit interface; other site
101510006873	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
101510006874	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
101510006875	putative active site [active]
101510006876	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
101510006877	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
101510006878	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
101510006879	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
101510006880	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510006881	Cupin domain; Region: Cupin_2; cl09118
101510006882	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
101510006883	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
101510006884	FMN-binding pocket [chemical binding]; other site
101510006885	flavin binding motif; other site
101510006886	phosphate binding motif [ion binding]; other site
101510006887	beta-alpha-beta structure motif; other site
101510006888	NAD binding pocket [chemical binding]; other site
101510006889	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510006890	catalytic loop [active]
101510006891	iron binding site [ion binding]; other site
101510006892	Protein of unknown function (DUF3445); Region: DUF3445; pfam11927
101510006893	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
101510006894	Helix-turn-helix domains; Region: HTH; cl00088
101510006895	HutD; Region: HutD; cl01532
101510006896	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
101510006897	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
101510006898	non-specific DNA binding site [nucleotide binding]; other site
101510006899	salt bridge; other site
101510006900	sequence-specific DNA binding site [nucleotide binding]; other site
101510006901	anthranilate synthase component I; Provisional; Region: PRK13573
101510006902	Cupin domain; Region: Cupin_2; cl09118
101510006903	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
101510006904	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510006905	NAD(P) binding site [chemical binding]; other site
101510006906	catalytic residues [active]
101510006907	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
101510006908	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
101510006909	NAD binding site [chemical binding]; other site
101510006910	catalytic Zn binding site [ion binding]; other site
101510006911	substrate binding site [chemical binding]; other site
101510006912	structural Zn binding site [ion binding]; other site
101510006913	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
101510006914	Helix-turn-helix domains; Region: HTH; cl00088
101510006915	tyramine oxidase; Provisional; Region: tynA; PRK11504
101510006916	Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727
101510006917	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
101510006918	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
101510006919	Amino acid permease; Region: AA_permease; cl00524
101510006920	Amino acid permease; Region: AA_permease; cl00524
101510006921	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
101510006922	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
101510006923	active site
101510006924	hypothetical protein; Provisional; Region: PRK13560
101510006925	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
101510006926	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
101510006927	putative active site [active]
101510006928	heme pocket [chemical binding]; other site
101510006929	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
101510006930	dimer interface [polypeptide binding]; other site
101510006931	phosphorylation site [posttranslational modification]
101510006932	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510006933	ATP binding site [chemical binding]; other site
101510006934	Mg2+ binding site [ion binding]; other site
101510006935	G-X-G motif; other site
101510006936	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510006937	active site
101510006938	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510006939	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
101510006940	[2Fe-2S] cluster binding site [ion binding]; other site
101510006941	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
101510006942	putative alpha subunit interface [polypeptide binding]; other site
101510006943	putative active site [active]
101510006944	putative substrate binding site [chemical binding]; other site
101510006945	Fe binding site [ion binding]; other site
101510006946	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510006947	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510006948	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510006949	NAD(P) binding site [chemical binding]; other site
101510006950	active site
101510006951	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
101510006952	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
101510006953	FMN-binding pocket [chemical binding]; other site
101510006954	flavin binding motif; other site
101510006955	phosphate binding motif [ion binding]; other site
101510006956	beta-alpha-beta structure motif; other site
101510006957	NAD binding pocket [chemical binding]; other site
101510006958	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510006959	catalytic loop [active]
101510006960	iron binding site [ion binding]; other site
101510006961	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
101510006962	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510006963	active site
101510006964	phosphorylation site [posttranslational modification]
101510006965	intermolecular recognition site; other site
101510006966	dimerization interface [polypeptide binding]; other site
101510006967	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510006968	DNA binding residues [nucleotide binding]
101510006969	dimerization interface [polypeptide binding]; other site
101510006970	Flavin Reductases; Region: FlaRed; cl00801
101510006971	Sodium:solute symporter family; Region: SSF; cl00456
101510006972	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
101510006973	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
101510006974	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
101510006975	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
101510006976	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
101510006977	Cupin domain; Region: Cupin_2; cl09118
101510006978	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510006979	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510006980	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
101510006981	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
101510006982	FAD binding pocket [chemical binding]; other site
101510006983	FAD binding motif [chemical binding]; other site
101510006984	phosphate binding motif [ion binding]; other site
101510006985	beta-alpha-beta structure motif; other site
101510006986	NAD(p) ribose binding residues [chemical binding]; other site
101510006987	NAD binding pocket [chemical binding]; other site
101510006988	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
101510006989	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510006990	catalytic loop [active]
101510006991	iron binding site [ion binding]; other site
101510006992	Domain of unknown function DUF59; Region: DUF59; cl00941
101510006993	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
101510006994	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346
101510006995	Phenylacetic acid degradation B; Region: PaaB; cl01371
101510006996	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346
101510006997	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
101510006998	enoyl-CoA hydratase; Provisional; Region: PRK08140
101510006999	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510007000	substrate binding site [chemical binding]; other site
101510007001	oxyanion hole (OAH) forming residues; other site
101510007002	trimer interface [polypeptide binding]; other site
101510007003	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
101510007004	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510007005	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
101510007006	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
101510007007	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510007008	substrate binding site [chemical binding]; other site
101510007009	oxyanion hole (OAH) forming residues; other site
101510007010	trimer interface [polypeptide binding]; other site
101510007011	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
101510007012	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
101510007013	dimer interface [polypeptide binding]; other site
101510007014	active site
101510007015	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
101510007016	N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
101510007017	substrate binding site [chemical binding]; other site
101510007018	dimer interface [polypeptide binding]; other site
101510007019	NADP binding site [chemical binding]; other site
101510007020	catalytic residues [active]
101510007021	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
101510007022	active site 2 [active]
101510007023	active site 1 [active]
101510007024	EthD protein; Region: EthD; cl06234
101510007025	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
101510007026	CoenzymeA binding site [chemical binding]; other site
101510007027	subunit interaction site [polypeptide binding]; other site
101510007028	PHB binding site; other site
101510007029	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510007030	DNA helicase, putative; Region: TIGR00376
101510007031	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
101510007032	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
101510007033	putative active site [active]
101510007034	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
101510007035	putative FMN binding site [chemical binding]; other site
101510007036	Helix-turn-helix domains; Region: HTH; cl00088
101510007037	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
101510007038	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510007039	DNA-binding site [nucleotide binding]; DNA binding site
101510007040	UTRA domain; Region: UTRA; cl01230
101510007041	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510007042	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510007043	active site
101510007044	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
101510007045	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
101510007046	putative active site [active]
101510007047	putative catalytic site [active]
101510007048	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
101510007049	active site 2 [active]
101510007050	active site 1 [active]
101510007051	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
101510007052	CoA-transferase family III; Region: CoA_transf_3; pfam02515
101510007053	Transcriptional regulators [Transcription]; Region: PurR; COG1609
101510007054	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
101510007055	DNA binding site [nucleotide binding]
101510007056	domain linker motif; other site
101510007057	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_7; cd06285
101510007058	putative dimerization interface [polypeptide binding]; other site
101510007059	putative ligand binding site [chemical binding]; other site
101510007060	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
101510007061	inhibitor site; inhibition site
101510007062	active site
101510007063	dimer interface [polypeptide binding]; other site
101510007064	catalytic residue [active]
101510007065	Natural resistance-associated macrophage protein; Region: Nramp; cl00836
101510007066	YCII-related domain; Region: YCII; cl00999
101510007067	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510007068	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
101510007069	CGNR zinc finger; Region: zf-CGNR; pfam11706
101510007070	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
101510007071	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
101510007072	active site
101510007073	non-prolyl cis peptide bond; other site
101510007074	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
101510007075	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510007076	active site
101510007077	aromatic amino acid exporter; Provisional; Region: PRK11689
101510007078	EamA-like transporter family; Region: EamA; cl01037
101510007079	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
101510007080	active site
101510007081	cosubstrate binding site; other site
101510007082	substrate binding site [chemical binding]; other site
101510007083	catalytic site [active]
101510007084	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
101510007085	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510007086	putative substrate translocation pore; other site
101510007087	Transcriptional regulators [Transcription]; Region: GntR; COG1802
101510007088	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510007089	DNA-binding site [nucleotide binding]; DNA binding site
101510007090	FCD domain; Region: FCD; cl11656
101510007091	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
101510007092	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510007093	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
101510007094	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
101510007095	inhibitor site; inhibition site
101510007096	active site
101510007097	dimer interface [polypeptide binding]; other site
101510007098	catalytic residue [active]
101510007099	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
101510007100	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510007101	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
101510007102	tetrameric interface [polypeptide binding]; other site
101510007103	NAD binding site [chemical binding]; other site
101510007104	catalytic residues [active]
101510007105	substrate binding site [chemical binding]; other site
101510007106	Transcription factor WhiB; Region: Whib; pfam02467
101510007107	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
101510007108	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
101510007109	P-loop; other site
101510007110	Magnesium ion binding site [ion binding]; other site
101510007111	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510007112	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
101510007113	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
101510007114	dimer interface [polypeptide binding]; other site
101510007115	NADP binding site [chemical binding]; other site
101510007116	catalytic residues [active]
101510007117	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
101510007118	tetramer (dimer of dimers) interface [polypeptide binding]; other site
101510007119	active site
101510007120	dimer interface [polypeptide binding]; other site
101510007121	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
101510007122	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
101510007123	D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
101510007124	N- and C-terminal domain interface [polypeptide binding]; other site
101510007125	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
101510007126	active site
101510007127	catalytic site [active]
101510007128	metal binding site [ion binding]; metal-binding site
101510007129	xylulose binding site [chemical binding]; other site
101510007130	putative ATP binding site [chemical binding]; other site
101510007131	homodimer interface [polypeptide binding]; other site
101510007132	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510007133	NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078
101510007134	NAD(P) binding site [chemical binding]; other site
101510007135	catalytic residues [active]
101510007136	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
101510007137	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510007138	Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970
101510007139	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
101510007140	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510007141	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
101510007142	NAD(P) binding site [chemical binding]; other site
101510007143	active site
101510007144	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
101510007145	TM-ABC transporter signature motif; other site
101510007146	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
101510007147	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
101510007148	Walker A/P-loop; other site
101510007149	ATP binding site [chemical binding]; other site
101510007150	Q-loop/lid; other site
101510007151	ABC transporter signature motif; other site
101510007152	Walker B; other site
101510007153	D-loop; other site
101510007154	H-loop/switch region; other site
101510007155	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
101510007156	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
101510007157	ligand binding site [chemical binding]; other site
101510007158	Transcriptional regulators [Transcription]; Region: FadR; COG2186
101510007159	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510007160	DNA-binding site [nucleotide binding]; DNA binding site
101510007161	FCD domain; Region: FCD; cl11656
101510007162	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
101510007163	hydrophobic ligand binding site; other site
101510007164	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510007165	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
101510007166	NAD(P) binding site [chemical binding]; other site
101510007167	active site
101510007168	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510007169	FAD binding domain; Region: FAD_binding_2; pfam00890
101510007170	YCII-related domain; Region: YCII; cl00999
101510007171	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510007172	Helix-turn-helix domains; Region: HTH; cl00088
101510007173	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510007174	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510007175	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510007176	putative substrate translocation pore; other site
101510007177	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510007178	Helix-turn-helix domains; Region: HTH; cl00088
101510007179	short chain dehydrogenase; Provisional; Region: PRK05872
101510007180	classical (c) SDRs; Region: SDR_c; cd05233
101510007181	NAD(P) binding site [chemical binding]; other site
101510007182	active site
101510007183	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
101510007184	Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918
101510007185	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
101510007186	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510007187	ATP binding site [chemical binding]; other site
101510007188	Mg2+ binding site [ion binding]; other site
101510007189	G-X-G motif; other site
101510007190	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510007191	active site
101510007192	phosphorylation site [posttranslational modification]
101510007193	intermolecular recognition site; other site
101510007194	benzoate transport; Region: 2A0115; TIGR00895
101510007195	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510007196	putative substrate translocation pore; other site
101510007197	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
101510007198	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
101510007199	metal binding site [ion binding]; metal-binding site
101510007200	putative dimer interface [polypeptide binding]; other site
101510007201	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510007202	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
101510007203	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510007204	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
101510007205	lipoyl synthase; Provisional; Region: PRK05481
101510007206	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
101510007207	FeS/SAM binding site; other site
101510007208	glycine dehydrogenase; Provisional; Region: PRK05367
101510007209	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
101510007210	tetramer interface [polypeptide binding]; other site
101510007211	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510007212	catalytic residue [active]
101510007213	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
101510007214	tetramer interface [polypeptide binding]; other site
101510007215	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510007216	catalytic residue [active]
101510007217	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
101510007218	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
101510007219	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
101510007220	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
101510007221	lipoyl attachment site [posttranslational modification]; other site
101510007222	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
101510007223	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
101510007224	dimer interface [polypeptide binding]; other site
101510007225	glycine-pyridoxal phosphate binding site [chemical binding]; other site
101510007226	active site
101510007227	folate binding site [chemical binding]; other site
101510007228	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
101510007229	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
101510007230	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
101510007231	Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039
101510007232	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780
101510007233	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780
101510007234	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780
101510007235	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
101510007236	CoA-transferase family III; Region: CoA_transf_3; pfam02515
101510007237	Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158
101510007238	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
101510007239	Transcriptional regulators [Transcription]; Region: FadR; COG2186
101510007240	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510007241	DNA-binding site [nucleotide binding]; DNA binding site
101510007242	FCD domain; Region: FCD; cl11656
101510007243	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
101510007244	CoA-transferase family III; Region: CoA_transf_3; pfam02515
101510007245	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510007246	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510007247	active site
101510007248	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510007249	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510007250	putative substrate translocation pore; other site
101510007251	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
101510007252	Helix-turn-helix domains; Region: HTH; cl00088
101510007253	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
101510007254	dimerization interface [polypeptide binding]; other site
101510007255	substrate binding pocket [chemical binding]; other site
101510007256	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
101510007257	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
101510007258	Aspartase; Region: Aspartase; cd01357
101510007259	active sites [active]
101510007260	tetramer interface [polypeptide binding]; other site
101510007261	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
101510007262	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510007263	DNA-binding site [nucleotide binding]; DNA binding site
101510007264	FCD domain; Region: FCD; cl11656
101510007265	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
101510007266	Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915
101510007267	Cytochrome P450; Region: p450; cl12078
101510007268	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
101510007269	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
101510007270	FMN-binding pocket [chemical binding]; other site
101510007271	flavin binding motif; other site
101510007272	phosphate binding motif [ion binding]; other site
101510007273	beta-alpha-beta structure motif; other site
101510007274	NAD binding pocket [chemical binding]; other site
101510007275	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510007276	catalytic loop [active]
101510007277	iron binding site [ion binding]; other site
101510007278	tetracycline repressor protein TetR; Provisional; Region: PRK13756
101510007279	Helix-turn-helix domains; Region: HTH; cl00088
101510007280	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
101510007281	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
101510007282	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
101510007283	putative NAD(P) binding site [chemical binding]; other site
101510007284	Helix-turn-helix domains; Region: HTH; cl00088
101510007285	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510007286	ABC-2 type transporter; Region: ABC2_membrane; cl11417
101510007287	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
101510007288	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
101510007289	Walker A/P-loop; other site
101510007290	ATP binding site [chemical binding]; other site
101510007291	Q-loop/lid; other site
101510007292	ABC transporter signature motif; other site
101510007293	Walker B; other site
101510007294	D-loop; other site
101510007295	H-loop/switch region; other site
101510007296	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510007297	Helix-turn-helix domains; Region: HTH; cl00088
101510007298	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825
101510007299	putative hydrophobic ligand binding site [chemical binding]; other site
101510007300	Glutaminase; Region: Glutaminase; cl00907
101510007301	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
101510007302	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
101510007303	argininosuccinate lyase; Provisional; Region: PRK02186
101510007304	Major Facilitator Superfamily; Region: MFS_1; pfam07690
101510007305	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
101510007306	homodimer interface [polypeptide binding]; other site
101510007307	substrate-cofactor binding pocket; other site
101510007308	Aminotransferase class IV; Region: Aminotran_4; pfam01063
101510007309	catalytic residue [active]
101510007310	FemAB family; Region: FemAB; cl11444
101510007311	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
101510007312	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
101510007313	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
101510007314	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
101510007315	active site
101510007316	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
101510007317	KamA family protein; Region: TIGR00238; cl15377
101510007318	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
101510007319	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
101510007320	Protein of unknown function (DUF3705); Region: DUF3705; pfam12492
101510007321	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
101510007322	CoenzymeA binding site [chemical binding]; other site
101510007323	subunit interaction site [polypeptide binding]; other site
101510007324	PHB binding site; other site
101510007325	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
101510007326	amidase; Provisional; Region: PRK07486
101510007327	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
101510007328	FAD binding domain; Region: FAD_binding_4; pfam01565
101510007329	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
101510007330	benzoylformate decarboxylase; Reviewed; Region: PRK07092
101510007331	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
101510007332	PYR/PP interface [polypeptide binding]; other site
101510007333	dimer interface [polypeptide binding]; other site
101510007334	TPP binding site [chemical binding]; other site
101510007335	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
101510007336	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
101510007337	TPP-binding site [chemical binding]; other site
101510007338	dimer interface [polypeptide binding]; other site
101510007339	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510007340	NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152
101510007341	NAD(P) binding site [chemical binding]; other site
101510007342	catalytic residues [active]
101510007343	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
101510007344	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510007345	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
101510007346	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
101510007347	active site
101510007348	substrate binding site [chemical binding]; other site
101510007349	FMN binding site [chemical binding]; other site
101510007350	putative catalytic residues [active]
101510007351	benzoate transport; Region: 2A0115; TIGR00895
101510007352	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510007353	putative substrate translocation pore; other site
101510007354	Transcriptional regulator [Transcription]; Region: LysR; COG0583
101510007355	Helix-turn-helix domains; Region: HTH; cl00088
101510007356	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
101510007357	substrate binding pocket [chemical binding]; other site
101510007358	dimerization interface [polypeptide binding]; other site
101510007359	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
101510007360	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510007361	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
101510007362	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
101510007363	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
101510007364	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510007365	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
101510007366	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510007367	Helix-turn-helix domains; Region: HTH; cl00088
101510007368	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510007369	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510007370	Helix-turn-helix domains; Region: HTH; cl00088
101510007371	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510007372	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
101510007373	Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177
101510007374	active site
101510007375	dimer interface [polypeptide binding]; other site
101510007376	metal binding site [ion binding]; metal-binding site
101510007377	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl01383
101510007378	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
101510007379	active site
101510007380	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
101510007381	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510007382	putative substrate translocation pore; other site
101510007383	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510007384	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
101510007385	Ligand Binding Site [chemical binding]; other site
101510007386	RNB domain; Region: RNB; pfam00773
101510007387	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
101510007388	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510007389	DNA binding site [nucleotide binding]
101510007390	Int/Topo IB signature motif; other site
101510007391	active site
101510007392	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
101510007393	DNA binding site [nucleotide binding]
101510007394	Int/Topo IB signature motif; other site
101510007395	active site
101510007396	catalytic residues [active]
101510007397	lipid-transfer protein; Provisional; Region: PRK08256
101510007398	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
101510007399	active site
101510007400	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
101510007401	active site
101510007402	catalytic site [active]
101510007403	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
101510007404	active site 2 [active]
101510007405	active site 1 [active]
101510007406	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
101510007407	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510007408	NAD(P) binding site [chemical binding]; other site
101510007409	active site
101510007410	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510007411	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
101510007412	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510007413	Helix-turn-helix domains; Region: HTH; cl00088
101510007414	Helix-turn-helix domains; Region: HTH; cl00088
101510007415	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
101510007416	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
101510007417	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
101510007418	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
101510007419	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
101510007420	Amino acid permease; Region: AA_permease; cl00524
101510007421	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
101510007422	putative active site [active]
101510007423	catalytic triad [active]
101510007424	putative dimer interface [polypeptide binding]; other site
101510007425	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
101510007426	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510007427	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510007428	DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534
101510007429	DNA-binding site [nucleotide binding]; DNA binding site
101510007430	FCD domain; Region: FCD; cl11656
101510007431	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510007432	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510007433	putative substrate translocation pore; other site
101510007434	Protein of unknown function (DUF2848); Region: DUF2848; pfam11010
101510007435	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510007436	active site
101510007437	ATP binding site [chemical binding]; other site
101510007438	substrate binding site [chemical binding]; other site
101510007439	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
101510007440	substrate binding site [chemical binding]; other site
101510007441	activation loop (A-loop); other site
101510007442	activation loop (A-loop); other site
101510007443	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510007444	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
101510007445	TPR motif; other site
101510007446	binding surface
101510007447	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510007448	DNA binding residues [nucleotide binding]
101510007449	dimerization interface [polypeptide binding]; other site
101510007450	Transcriptional regulators [Transcription]; Region: MarR; COG1846
101510007451	Helix-turn-helix domains; Region: HTH; cl00088
101510007452	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510007453	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510007454	acetyl-CoA acetyltransferase; Provisional; Region: PRK06205
101510007455	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
101510007456	dimer interface [polypeptide binding]; other site
101510007457	active site
101510007458	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
101510007459	putative active site [active]
101510007460	putative catalytic site [active]
101510007461	acetyl-CoA acetyltransferase; Provisional; Region: PRK06205
101510007462	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
101510007463	dimer interface [polypeptide binding]; other site
101510007464	active site
101510007465	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510007466	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510007467	active site
101510007468	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510007469	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510007470	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510007471	active site
101510007472	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510007473	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510007474	NAD(P) binding site [chemical binding]; other site
101510007475	active site
101510007476	Transcriptional regulator [Transcription]; Region: LysR; COG0583
101510007477	Helix-turn-helix domains; Region: HTH; cl00088
101510007478	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
101510007479	dimerization interface [polypeptide binding]; other site
101510007480	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
101510007481	Helix-turn-helix domains; Region: HTH; cl00088
101510007482	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
101510007483	dimerization interface [polypeptide binding]; other site
101510007484	Transcriptional regulators [Transcription]; Region: GntR; COG1802
101510007485	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510007486	DNA-binding site [nucleotide binding]; DNA binding site
101510007487	FCD domain; Region: FCD; cl11656
101510007488	Helix-turn-helix domains; Region: HTH; cl00088
101510007489	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
101510007490	Amino acid permease; Region: AA_permease; cl00524
101510007491	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
101510007492	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
101510007493	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
101510007494	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
101510007495	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
101510007496	putative molybdopterin cofactor binding site [chemical binding]; other site
101510007497	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
101510007498	putative molybdopterin cofactor binding site; other site
101510007499	hypothetical protein; Provisional; Region: PRK06184
101510007500	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510007501	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
101510007502	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
101510007503	dimer interface [polypeptide binding]; other site
101510007504	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
101510007505	active site
101510007506	Fe binding site [ion binding]; other site
101510007507	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
101510007508	Helix-turn-helix domains; Region: HTH; cl00088
101510007509	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
101510007510	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510007511	NAD(P) binding pocket [chemical binding]; other site
101510007512	Amino acid permease; Region: AA_permease; cl00524
101510007513	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
101510007514	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
101510007515	active site
101510007516	FMN binding site [chemical binding]; other site
101510007517	substrate binding site [chemical binding]; other site
101510007518	putative catalytic residue [active]
101510007519	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826
101510007520	putative hydrophobic ligand binding site [chemical binding]; other site
101510007521	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
101510007522	putative DNA binding site [nucleotide binding]; other site
101510007523	putative Zn2+ binding site [ion binding]; other site
101510007524	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510007525	Helix-turn-helix domains; Region: HTH; cl00088
101510007526	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510007527	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510007528	putative substrate translocation pore; other site
101510007529	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
101510007530	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510007531	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
101510007532	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
101510007533	trimer interface [polypeptide binding]; other site
101510007534	active site
101510007535	dimer interface [polypeptide binding]; other site
101510007536	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
101510007537	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
101510007538	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510007539	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510007540	active site
101510007541	ATP binding site [chemical binding]; other site
101510007542	substrate binding site [chemical binding]; other site
101510007543	activation loop (A-loop); other site
101510007544	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510007545	Helix-turn-helix domains; Region: HTH; cl00088
101510007546	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
101510007547	DinB superfamily; Region: DinB_2; cl00986
101510007548	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510007549	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510007550	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510007551	active site
101510007552	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510007553	Helix-turn-helix domains; Region: HTH; cl00088
101510007554	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
101510007555	Stress responsive A/B Barrel Domain; Region: Dabb; cl06768
101510007556	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
101510007557	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
101510007558	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510007559	NAD binding site [chemical binding]; other site
101510007560	catalytic residues [active]
101510007561	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
101510007562	CoA-transferase family III; Region: CoA_transf_3; pfam02515
101510007563	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
101510007564	enoyl-CoA hydratase; Provisional; Region: PRK09245
101510007565	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510007566	substrate binding site [chemical binding]; other site
101510007567	oxyanion hole (OAH) forming residues; other site
101510007568	trimer interface [polypeptide binding]; other site
101510007569	Uncharacterized conserved protein [Function unknown]; Region: COG3391
101510007570	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
101510007571	Chromate resistance exported protein; Region: Chrome_Resist; cl01744
101510007572	Chromate transporter; Region: Chromate_transp; pfam02417
101510007573	Chromate transporter; Region: Chromate_transp; pfam02417
101510007574	Cytochrome P450; Region: p450; cl12078
101510007575	3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141
101510007576	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510007577	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
101510007578	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510007579	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
101510007580	NAD(P) binding site [chemical binding]; other site
101510007581	catalytic residues [active]
101510007582	short chain dehydrogenase; Provisional; Region: PRK07825
101510007583	classical (c) SDRs; Region: SDR_c; cd05233
101510007584	NAD(P) binding site [chemical binding]; other site
101510007585	active site
101510007586	Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
101510007587	formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
101510007588	NAD binding site [chemical binding]; other site
101510007589	catalytic Zn binding site [ion binding]; other site
101510007590	structural Zn binding site [ion binding]; other site
101510007591	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
101510007592	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
101510007593	DNA binding residues [nucleotide binding]
101510007594	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614
101510007595	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510007596	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
101510007597	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
101510007598	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
101510007599	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
101510007600	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
101510007601	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510007602	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510007603	active site
101510007604	short chain dehydrogenase; Provisional; Region: PRK08251
101510007605	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510007606	NAD(P) binding site [chemical binding]; other site
101510007607	active site
101510007608	Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173
101510007609	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
101510007610	putative active site [active]
101510007611	putative substrate binding site [chemical binding]; other site
101510007612	ATP binding site [chemical binding]; other site
101510007613	Helix-turn-helix domains; Region: HTH; cl00088
101510007614	Uncharacterized conserved protein [Function unknown]; Region: COG3268
101510007615	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510007616	NAD(P) binding site [chemical binding]; other site
101510007617	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
101510007618	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
101510007619	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510007620	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
101510007621	substrate binding pocket [chemical binding]; other site
101510007622	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510007623	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
101510007624	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
101510007625	NAD(P) binding site [chemical binding]; other site
101510007626	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101
101510007627	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510007628	NAD(P) binding site [chemical binding]; other site
101510007629	catalytic residues [active]
101510007630	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
101510007631	WHG domain; Region: WHG; pfam13305
101510007632	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
101510007633	putative active site [active]
101510007634	putative FMN binding site [chemical binding]; other site
101510007635	putative substrate binding site [chemical binding]; other site
101510007636	putative catalytic residue [active]
101510007637	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
101510007638	potential catalytic triad [active]
101510007639	conserved cys residue [active]
101510007640	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510007641	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510007642	putative substrate translocation pore; other site
101510007643	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
101510007644	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
101510007645	catalytic residues [active]
101510007646	catalytic nucleophile [active]
101510007647	Presynaptic Site I dimer interface [polypeptide binding]; other site
101510007648	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
101510007649	Synaptic Flat tetramer interface [polypeptide binding]; other site
101510007650	Synaptic Site I dimer interface [polypeptide binding]; other site
101510007651	DNA binding site [nucleotide binding]
101510007652	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
101510007653	DNA-binding interface [nucleotide binding]; DNA binding site
101510007654	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
101510007655	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
101510007656	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
101510007657	catalytic residues [active]
101510007658	catalytic nucleophile [active]
101510007659	Presynaptic Site I dimer interface [polypeptide binding]; other site
101510007660	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
101510007661	Synaptic Flat tetramer interface [polypeptide binding]; other site
101510007662	Synaptic Site I dimer interface [polypeptide binding]; other site
101510007663	DNA binding site [nucleotide binding]
101510007664	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
101510007665	DNA-binding interface [nucleotide binding]; DNA binding site
101510007666	Fic/DOC family; Region: Fic; cl00960
101510007667	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
101510007668	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088
101510007669	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
101510007670	DNA binding site [nucleotide binding]
101510007671	Int/Topo IB signature motif; other site
101510007672	active site
101510007673	catalytic residues [active]
101510007674	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
101510007675	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
101510007676	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
101510007677	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
101510007678	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
101510007679	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
101510007680	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
101510007681	Walker A/P-loop; other site
101510007682	ATP binding site [chemical binding]; other site
101510007683	Q-loop/lid; other site
101510007684	ABC transporter signature motif; other site
101510007685	Walker B; other site
101510007686	D-loop; other site
101510007687	H-loop/switch region; other site
101510007688	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
101510007689	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
101510007690	Walker A/P-loop; other site
101510007691	ATP binding site [chemical binding]; other site
101510007692	Q-loop/lid; other site
101510007693	ABC transporter signature motif; other site
101510007694	Walker B; other site
101510007695	D-loop; other site
101510007696	H-loop/switch region; other site
101510007697	MspA; Region: MspA; pfam09203
101510007698	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
101510007699	NodB motif; other site
101510007700	active site
101510007701	catalytic site [active]
101510007702	metal binding site [ion binding]; metal-binding site
101510007703	Predicted esterase [General function prediction only]; Region: COG0627
101510007704	hypothetical protein; Provisional; Region: PRK13685
101510007705	Aerotolerance regulator N-terminal; Region: BatA; cl06567
101510007706	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
101510007707	metal ion-dependent adhesion site (MIDAS); other site
101510007708	Interferon-induced transmembrane protein; Region: CD225; pfam04505
101510007709	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
101510007710	active site
101510007711	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
101510007712	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
101510007713	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
101510007714	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
101510007715	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
101510007716	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
101510007717	active site
101510007718	catalytic triad [active]
101510007719	oxyanion hole [active]
101510007720	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
101510007721	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
101510007722	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510007723	ATP binding site [chemical binding]; other site
101510007724	Mg2+ binding site [ion binding]; other site
101510007725	G-X-G motif; other site
101510007726	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
101510007727	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510007728	active site
101510007729	phosphorylation site [posttranslational modification]
101510007730	intermolecular recognition site; other site
101510007731	dimerization interface [polypeptide binding]; other site
101510007732	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
101510007733	DNA binding site [nucleotide binding]
101510007734	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
101510007735	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510007736	Walker A/P-loop; other site
101510007737	ATP binding site [chemical binding]; other site
101510007738	Q-loop/lid; other site
101510007739	ABC transporter signature motif; other site
101510007740	Walker B; other site
101510007741	D-loop; other site
101510007742	H-loop/switch region; other site
101510007743	TOBE domain; Region: TOBE_2; cl01440
101510007744	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
101510007745	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
101510007746	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510007747	dimer interface [polypeptide binding]; other site
101510007748	conserved gate region; other site
101510007749	putative PBP binding loops; other site
101510007750	ABC-ATPase subunit interface; other site
101510007751	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
101510007752	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
101510007753	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
101510007754	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
101510007755	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
101510007756	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
101510007757	putative active site; other site
101510007758	putative metal binding residues [ion binding]; other site
101510007759	signature motif; other site
101510007760	putative triphosphate binding site [ion binding]; other site
101510007761	CHAD domain; Region: CHAD; cl10506
101510007762	Bacitracin resistance protein BacA; Region: BacA; cl00858
101510007763	MspA; Region: MspA; pfam09203
101510007764	multiple promoter invertase; Provisional; Region: mpi; PRK13413
101510007765	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
101510007766	catalytic residues [active]
101510007767	catalytic nucleophile [active]
101510007768	Presynaptic Site I dimer interface [polypeptide binding]; other site
101510007769	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
101510007770	Synaptic Flat tetramer interface [polypeptide binding]; other site
101510007771	Synaptic Site I dimer interface [polypeptide binding]; other site
101510007772	DNA binding site [nucleotide binding]
101510007773	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
101510007774	DNA-binding interface [nucleotide binding]; DNA binding site
101510007775	Transposase [DNA replication, recombination, and repair]; Region: COG5421
101510007776	Protein of unknown function DUF262; Region: DUF262; cl14890
101510007777	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
101510007778	multiple promoter invertase; Provisional; Region: mpi; PRK13413
101510007779	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
101510007780	catalytic residues [active]
101510007781	catalytic nucleophile [active]
101510007782	Presynaptic Site I dimer interface [polypeptide binding]; other site
101510007783	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
101510007784	Synaptic Flat tetramer interface [polypeptide binding]; other site
101510007785	Synaptic Site I dimer interface [polypeptide binding]; other site
101510007786	DNA binding site [nucleotide binding]
101510007787	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
101510007788	DNA-binding interface [nucleotide binding]; DNA binding site
101510007789	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
101510007790	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
101510007791	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208
101510007792	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
101510007793	NAD binding site [chemical binding]; other site
101510007794	Phe binding site; other site
101510007795	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
101510007796	Amino acid permease; Region: AA_permease; cl00524
101510007797	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
101510007798	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
101510007799	dimer interface [polypeptide binding]; other site
101510007800	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
101510007801	active site
101510007802	Fe binding site [ion binding]; other site
101510007803	NMD3 family; Region: NMD3; pfam04981
101510007804	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510007805	Int/Topo IB signature motif; other site
101510007806	active site
101510007807	DNA binding site [nucleotide binding]
101510007808	Helix-turn-helix domains; Region: HTH; cl00088
101510007809	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
101510007810	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510007811	DNA binding site [nucleotide binding]
101510007812	Int/Topo IB signature motif; other site
101510007813	active site
101510007814	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
101510007815	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
101510007816	catalytic residues [active]
101510007817	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510007818	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510007819	active site
101510007820	ATP binding site [chemical binding]; other site
101510007821	substrate binding site [chemical binding]; other site
101510007822	activation loop (A-loop); other site
101510007823	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691
101510007824	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
101510007825	phosphopeptide binding site; other site
101510007826	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
101510007827	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510007828	dimerization interface [polypeptide binding]; other site
101510007829	DNA binding residues [nucleotide binding]
101510007830	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
101510007831	multiple promoter invertase; Provisional; Region: mpi; PRK13413
101510007832	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
101510007833	catalytic residues [active]
101510007834	catalytic nucleophile [active]
101510007835	Presynaptic Site I dimer interface [polypeptide binding]; other site
101510007836	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
101510007837	Synaptic Flat tetramer interface [polypeptide binding]; other site
101510007838	Synaptic Site I dimer interface [polypeptide binding]; other site
101510007839	DNA binding site [nucleotide binding]
101510007840	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
101510007841	DNA-binding interface [nucleotide binding]; DNA binding site
101510007842	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510007843	Phage integrase family; Region: Phage_integrase; pfam00589
101510007844	DNA binding site [nucleotide binding]
101510007845	Int/Topo IB signature motif; other site
101510007846	active site
101510007847	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
101510007848	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
101510007849	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510007850	DNA binding site [nucleotide binding]
101510007851	Int/Topo IB signature motif; other site
101510007852	active site
101510007853	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
101510007854	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510007855	DNA binding site [nucleotide binding]
101510007856	Int/Topo IB signature motif; other site
101510007857	active site
101510007858	Phage integrase family; Region: Phage_integrase; pfam00589
101510007859	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
101510007860	active site
101510007861	FMN binding site [chemical binding]; other site
101510007862	substrate binding site [chemical binding]; other site
101510007863	putative catalytic residue [active]
101510007864	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510007865	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
101510007866	active site
101510007867	catalytic site [active]
101510007868	Zn binding site [ion binding]; other site
101510007869	tetramer interface [polypeptide binding]; other site
101510007870	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
101510007871	active site
101510007872	homodimer interface [polypeptide binding]; other site
101510007873	homotetramer interface [polypeptide binding]; other site
101510007874	Transcriptional regulators [Transcription]; Region: PurR; COG1609
101510007875	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
101510007876	DNA binding site [nucleotide binding]
101510007877	domain linker motif; other site
101510007878	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_7; cd06285
101510007879	putative dimerization interface [polypeptide binding]; other site
101510007880	putative ligand binding site [chemical binding]; other site
101510007881	putative amidase; Provisional; Region: PRK06169
101510007882	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
101510007883	Putative cyclase; Region: Cyclase; cl00814
101510007884	classical (c) SDRs; Region: SDR_c; cd05233
101510007885	NAD(P) binding site [chemical binding]; other site
101510007886	active site
101510007887	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510007888	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510007889	NAD(P) binding site [chemical binding]; other site
101510007890	active site
101510007891	benzoate transport; Region: 2A0115; TIGR00895
101510007892	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510007893	putative substrate translocation pore; other site
101510007894	Transcription factor WhiB; Region: Whib; pfam02467
101510007895	Helix-turn-helix domains; Region: HTH; cl00088
101510007896	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510007897	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510007898	pyruvate kinase; Provisional; Region: PRK06247
101510007899	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
101510007900	domain interfaces; other site
101510007901	active site
101510007902	glyoxylate carboligase; Provisional; Region: PRK11269
101510007903	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
101510007904	PYR/PP interface [polypeptide binding]; other site
101510007905	dimer interface [polypeptide binding]; other site
101510007906	TPP binding site [chemical binding]; other site
101510007907	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
101510007908	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
101510007909	TPP-binding site [chemical binding]; other site
101510007910	2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505
101510007911	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510007912	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
101510007913	FAD binding domain; Region: FAD_binding_4; pfam01565
101510007914	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
101510007915	L-lactate permease; Region: Lactate_perm; cl00701
101510007916	Glycerate kinase family; Region: Gly_kinase; cl00841
101510007917	Transcription factor WhiB; Region: Whib; pfam02467
101510007918	Transcriptional regulators [Transcription]; Region: GntR; COG1802
101510007919	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510007920	DNA-binding site [nucleotide binding]; DNA binding site
101510007921	FCD domain; Region: FCD; cl11656
101510007922	Transposase, Mutator family; Region: Transposase_mut; pfam00872
101510007923	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510007924	DNA-binding site [nucleotide binding]; DNA binding site
101510007925	FCD domain; Region: FCD; cl11656
101510007926	glycolate transporter; Provisional; Region: PRK09695
101510007927	L-lactate permease; Region: Lactate_perm; cl00701
101510007928	FAD binding domain; Region: FAD_binding_4; pfam01565
101510007929	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
101510007930	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510007931	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510007932	DNA binding residues [nucleotide binding]
101510007933	dimerization interface [polypeptide binding]; other site
101510007934	Transposase, Mutator family; Region: Transposase_mut; pfam00872
101510007935	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510007936	Helix-turn-helix domains; Region: HTH; cl00088
101510007937	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510007938	enoyl-CoA hydratase; Provisional; Region: PRK06495
101510007939	substrate binding site [chemical binding]; other site
101510007940	oxyanion hole (OAH) forming residues; other site
101510007941	trimer interface [polypeptide binding]; other site
101510007942	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510007943	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510007944	active site
101510007945	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510007946	active site
101510007947	cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295
101510007948	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510007949	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
101510007950	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
101510007951	Integrase core domain; Region: rve; cl01316
101510007952	Transcription factor WhiB; Region: Whib; pfam02467
101510007953	Uncharacterized conserved protein [Function unknown]; Region: COG3391
101510007954	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
101510007955	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
101510007956	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
101510007957	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
101510007958	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
101510007959	structural tetrad; other site
101510007960	Predicted ATPase [General function prediction only]; Region: COG3899
101510007961	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
101510007962	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510007963	DNA binding residues [nucleotide binding]
101510007964	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
101510007965	DNA binding residues [nucleotide binding]
101510007966	Transcription factor WhiB; Region: Whib; pfam02467
101510007967	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
101510007968	Protein of unknown function (DUF419); Region: DUF419; cl15265
101510007969	MMPL family; Region: MMPL; pfam03176
101510007970	Transport protein; Region: actII; TIGR00833
101510007971	Helix-turn-helix domains; Region: HTH; cl00088
101510007972	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
101510007973	binding surface
101510007974	TPR motif; other site
101510007975	peroxiredoxin; Region: AhpC; TIGR03137
101510007976	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
101510007977	dimer interface [polypeptide binding]; other site
101510007978	decamer (pentamer of dimers) interface [polypeptide binding]; other site
101510007979	catalytic triad [active]
101510007980	peroxidatic and resolving cysteines [active]
101510007981	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
101510007982	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
101510007983	catalytic residue [active]
101510007984	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
101510007985	catalytic residues [active]
101510007986	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510007987	CHAT domain; Region: CHAT; cl02083
101510007988	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510007989	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
101510007990	dimer interface [polypeptide binding]; other site
101510007991	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510007992	Helix-turn-helix domains; Region: HTH; cl00088
101510007993	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
101510007994	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
101510007995	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
101510007996	NAD binding site [chemical binding]; other site
101510007997	catalytic Zn binding site [ion binding]; other site
101510007998	structural Zn binding site [ion binding]; other site
101510007999	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
101510008000	FAD binding domain; Region: FAD_binding_4; pfam01565
101510008001	Helix-turn-helix domains; Region: HTH; cl00088
101510008002	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510008003	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
101510008004	NAD(P) binding site [chemical binding]; other site
101510008005	catalytic residues [active]
101510008006	Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
101510008007	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
101510008008	catalytic Zn binding site [ion binding]; other site
101510008009	NAD binding site [chemical binding]; other site
101510008010	structural Zn binding site [ion binding]; other site
101510008011	Helix-turn-helix domain; Region: HTH_18; pfam12833
101510008012	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510008013	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
101510008014	aspartate aminotransferase; Provisional; Region: PRK05764
101510008015	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
101510008016	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510008017	homodimer interface [polypeptide binding]; other site
101510008018	catalytic residue [active]
101510008019	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
101510008020	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
101510008021	putative NAD(P) binding site [chemical binding]; other site
101510008022	catalytic Zn binding site [ion binding]; other site
101510008023	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510008024	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510008025	NAD(P) binding site [chemical binding]; other site
101510008026	active site
101510008027	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510008028	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510008029	putative substrate translocation pore; other site
101510008030	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
101510008031	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
101510008032	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
101510008033	LamB/YcsF family; Region: LamB_YcsF; cl00664
101510008034	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
101510008035	Helix-turn-helix domains; Region: HTH; cl00088
101510008036	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
101510008037	putative dimerization interface [polypeptide binding]; other site
101510008038	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510008039	gluconate 5-dehydrogenase; Provisional; Region: PRK06124
101510008040	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
101510008041	NADP binding site [chemical binding]; other site
101510008042	homodimer interface [polypeptide binding]; other site
101510008043	active site
101510008044	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
101510008045	ATP-binding site [chemical binding]; other site
101510008046	Gluconate-6-phosphate binding site [chemical binding]; other site
101510008047	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
101510008048	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
101510008049	tetramer interface [polypeptide binding]; other site
101510008050	TPP-binding site [chemical binding]; other site
101510008051	heterodimer interface [polypeptide binding]; other site
101510008052	phosphorylation loop region [posttranslational modification]
101510008053	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
101510008054	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
101510008055	PYR/PP interface [polypeptide binding]; other site
101510008056	dimer interface [polypeptide binding]; other site
101510008057	TPP binding site [chemical binding]; other site
101510008058	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
101510008059	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510008060	sarcosine oxidase, monomeric form; Region: soxA_mon; TIGR01377
101510008061	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
101510008062	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
101510008063	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
101510008064	putative active site [active]
101510008065	catalytic residue [active]
101510008066	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
101510008067	TPP-binding site [chemical binding]; other site
101510008068	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
101510008069	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
101510008070	Sulfatase; Region: Sulfatase; cl10460
101510008071	choline-sulfatase; Region: chol_sulfatase; TIGR03417
101510008072	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
101510008073	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
101510008074	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
101510008075	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
101510008076	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510008077	dimer interface [polypeptide binding]; other site
101510008078	conserved gate region; other site
101510008079	putative PBP binding loops; other site
101510008080	ABC-ATPase subunit interface; other site
101510008081	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
101510008082	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
101510008083	Walker A/P-loop; other site
101510008084	ATP binding site [chemical binding]; other site
101510008085	Q-loop/lid; other site
101510008086	ABC transporter signature motif; other site
101510008087	Walker B; other site
101510008088	D-loop; other site
101510008089	H-loop/switch region; other site
101510008090	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
101510008091	Walker A/P-loop; other site
101510008092	ATP binding site [chemical binding]; other site
101510008093	Q-loop/lid; other site
101510008094	ABC transporter signature motif; other site
101510008095	Walker B; other site
101510008096	D-loop; other site
101510008097	H-loop/switch region; other site
101510008098	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
101510008099	Predicted membrane protein [Function unknown]; Region: COG4129
101510008100	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510008101	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
101510008102	active site
101510008103	metal binding site [ion binding]; metal-binding site
101510008104	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
101510008105	active site
101510008106	NTP binding site [chemical binding]; other site
101510008107	metal binding triad [ion binding]; metal-binding site
101510008108	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
101510008109	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510008110	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
101510008111	Probable transposase; Region: OrfB_IS605; pfam01385
101510008112	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
101510008113	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
101510008114	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510008115	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510008116	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
101510008117	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
101510008118	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
101510008119	E3 interaction surface; other site
101510008120	lipoyl attachment site [posttranslational modification]; other site
101510008121	e3 binding domain; Region: E3_binding; pfam02817
101510008122	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
101510008123	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
101510008124	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
101510008125	alpha subunit interface [polypeptide binding]; other site
101510008126	TPP binding site [chemical binding]; other site
101510008127	heterodimer interface [polypeptide binding]; other site
101510008128	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
101510008129	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
101510008130	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
101510008131	tetramer interface [polypeptide binding]; other site
101510008132	TPP-binding site [chemical binding]; other site
101510008133	heterodimer interface [polypeptide binding]; other site
101510008134	phosphorylation loop region [posttranslational modification]
101510008135	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
101510008136	Helix-turn-helix domains; Region: HTH; cl00088
101510008137	Helix-turn-helix domains; Region: HTH; cl00088
101510008138	Protein of unknown function DUF124; Region: DUF124; cl00884
101510008139	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
101510008140	Domain of unknown function DUF21; Region: DUF21; pfam01595
101510008141	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
101510008142	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
101510008143	Domain of unknown function DUF21; Region: DUF21; pfam01595
101510008144	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
101510008145	Transporter associated domain; Region: CorC_HlyC; cl08393
101510008146	DsrE/DsrF-like family; Region: DrsE; cl00672
101510008147	radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043
101510008148	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
101510008149	FeS/SAM binding site; other site
101510008150	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
101510008151	AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192
101510008152	AIR synthase-related protein, MSMEG_0567 C-terminal family; Region: MSMEG_0567_Cter; TIGR04050
101510008153	dimerization interface [polypeptide binding]; other site
101510008154	putative ATP binding site [chemical binding]; other site
101510008155	Predicted amidohydrolase [General function prediction only]; Region: COG0388
101510008156	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
101510008157	active site
101510008158	catalytic triad [active]
101510008159	dimer interface [polypeptide binding]; other site
101510008160	MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042
101510008161	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
101510008162	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
101510008163	Predicted amidohydrolase [General function prediction only]; Region: COG0388
101510008164	active site
101510008165	catalytic triad [active]
101510008166	dimer interface [polypeptide binding]; other site
101510008167	glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047
101510008168	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
101510008169	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
101510008170	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
101510008171	putative DNA binding site [nucleotide binding]; other site
101510008172	putative Zn2+ binding site [ion binding]; other site
101510008173	Helix-turn-helix domains; Region: HTH; cl00088
101510008174	AzlC protein; Region: AzlC; cl00570
101510008175	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
101510008176	glycogen branching enzyme; Provisional; Region: PRK14705
101510008177	tetracycline repressor protein TetR; Provisional; Region: PRK13756
101510008178	Helix-turn-helix domains; Region: HTH; cl00088
101510008179	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
101510008180	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
101510008181	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
101510008182	putative di-iron ligands [ion binding]; other site
101510008183	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
101510008184	Transcription factor WhiB; Region: Whib; pfam02467
101510008185	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510008186	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510008187	active site
101510008188	Transcriptional regulator [Transcription]; Region: LysR; COG0583
101510008189	Helix-turn-helix domains; Region: HTH; cl00088
101510008190	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
101510008191	putative dimerization interface [polypeptide binding]; other site
101510008192	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
101510008193	homoserine O-acetyltransferase; Provisional; Region: metX; cl15472
101510008194	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
101510008195	CoA-transferase family III; Region: CoA_transf_3; pfam02515
101510008196	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
101510008197	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
101510008198	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
101510008199	dimer interface [polypeptide binding]; other site
101510008200	phosphorylation site [posttranslational modification]
101510008201	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510008202	ATP binding site [chemical binding]; other site
101510008203	Mg2+ binding site [ion binding]; other site
101510008204	G-X-G motif; other site
101510008205	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
101510008206	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510008207	active site
101510008208	phosphorylation site [posttranslational modification]
101510008209	intermolecular recognition site; other site
101510008210	dimerization interface [polypeptide binding]; other site
101510008211	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
101510008212	DNA binding site [nucleotide binding]
101510008213	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
101510008214	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510008215	putative substrate translocation pore; other site
101510008216	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
101510008217	PYR/PP interface [polypeptide binding]; other site
101510008218	dimer interface [polypeptide binding]; other site
101510008219	TPP binding site [chemical binding]; other site
101510008220	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
101510008221	sulfopyruvate decarboxylase, beta subunit; Region: sulfopy_beta; TIGR03846
101510008222	TPP-binding site [chemical binding]; other site
101510008223	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
101510008224	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
101510008225	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
101510008226	NAD(P) binding site [chemical binding]; other site
101510008227	catalytic residues [active]
101510008228	Barstar_SaI14_like contains sequences that are similar to SaI14, an RNAase inhibitor, which are members of the Barstar family. Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds...; Region: Barstar_SaI14_like; cd05143
101510008229	putative RNAase interaction site [polypeptide binding]; other site
101510008230	Transcription factor WhiB; Region: Whib; pfam02467
101510008231	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
101510008232	putative active site; other site
101510008233	putative metal binding residues [ion binding]; other site
101510008234	signature motif; other site
101510008235	putative triphosphate binding site [ion binding]; other site
101510008236	CHAD domain; Region: CHAD; cl10506
101510008237	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
101510008238	catalytic core [active]
101510008239	Amino acid permease; Region: AA_permease; cl00524
101510008240	Amino acid permease; Region: AA_permease; cl00524
101510008241	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
101510008242	dimerization interface [polypeptide binding]; other site
101510008243	putative DNA binding site [nucleotide binding]; other site
101510008244	putative Zn2+ binding site [ion binding]; other site
101510008245	Membrane transport protein; Region: Mem_trans; cl09117
101510008246	Low molecular weight phosphatase family; Region: LMWPc; cd00115
101510008247	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
101510008248	active site
101510008249	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510008250	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510008251	active site
101510008252	ATP binding site [chemical binding]; other site
101510008253	substrate binding site [chemical binding]; other site
101510008254	activation loop (A-loop); other site
101510008255	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
101510008256	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510008257	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510008258	DNA binding residues [nucleotide binding]
101510008259	dimerization interface [polypeptide binding]; other site
101510008260	Epoxide hydrolase N terminus; Region: EHN; pfam06441
101510008261	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
101510008262	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
101510008263	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510008264	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510008265	active site
101510008266	ATP binding site [chemical binding]; other site
101510008267	substrate binding site [chemical binding]; other site
101510008268	activation loop (A-loop); other site
101510008269	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510008270	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510008271	DNA binding residues [nucleotide binding]
101510008272	dimerization interface [polypeptide binding]; other site
101510008273	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
101510008274	Isochorismatase family; Region: Isochorismatase; pfam00857
101510008275	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
101510008276	catalytic triad [active]
101510008277	conserved cis-peptide bond; other site
101510008278	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
101510008279	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
101510008280	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
101510008281	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510008282	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510008283	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
101510008284	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
101510008285	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
101510008286	E3 interaction surface; other site
101510008287	lipoyl attachment site [posttranslational modification]; other site
101510008288	e3 binding domain; Region: E3_binding; pfam02817
101510008289	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
101510008290	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
101510008291	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
101510008292	alpha subunit interface [polypeptide binding]; other site
101510008293	TPP binding site [chemical binding]; other site
101510008294	heterodimer interface [polypeptide binding]; other site
101510008295	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
101510008296	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
101510008297	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
101510008298	TPP-binding site [chemical binding]; other site
101510008299	tetramer interface [polypeptide binding]; other site
101510008300	heterodimer interface [polypeptide binding]; other site
101510008301	phosphorylation loop region [posttranslational modification]
101510008302	Helix-turn-helix domains; Region: HTH; cl00088
101510008303	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
101510008304	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510008305	putative substrate translocation pore; other site
101510008306	Helix-turn-helix domains; Region: HTH; cl00088
101510008307	Predicted acyl esterases [General function prediction only]; Region: COG2936
101510008308	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
101510008309	Putative cyclase; Region: Cyclase; cl00814
101510008310	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
101510008311	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
101510008312	FAD binding domain; Region: FAD_binding_4; pfam01565
101510008313	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
101510008314	GAF domain; Region: GAF; cl00853
101510008315	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
101510008316	Helix-turn-helix domains; Region: HTH; cl00088
101510008317	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510008318	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510008319	active site
101510008320	putative acyltransferase; Provisional; Region: PRK05790
101510008321	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
101510008322	dimer interface [polypeptide binding]; other site
101510008323	active site
101510008324	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
101510008325	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
101510008326	NAD binding site [chemical binding]; other site
101510008327	homotetramer interface [polypeptide binding]; other site
101510008328	homodimer interface [polypeptide binding]; other site
101510008329	active site
101510008330	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
101510008331	tetracycline repressor protein TetR; Provisional; Region: PRK13756
101510008332	Helix-turn-helix domains; Region: HTH; cl00088
101510008333	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
101510008334	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
101510008335	PAS fold; Region: PAS_3; pfam08447
101510008336	putative active site [active]
101510008337	heme pocket [chemical binding]; other site
101510008338	ANTAR domain; Region: ANTAR; cl04297
101510008339	Lsr2; Region: Lsr2; pfam11774
101510008340	Gas vesicle protein; Region: Gas_vesicle; cl02954
101510008341	Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800
101510008342	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
101510008343	Gas vesicle protein; Region: Gas_vesicle; cl02954
101510008344	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
101510008345	putative hydrophobic ligand binding site [chemical binding]; other site
101510008346	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
101510008347	sensory histidine kinase AtoS; Provisional; Region: PRK11360
101510008348	ANTAR domain; Region: ANTAR; cl04297
101510008349	Domain of unknown function (DUF4383); Region: DUF4383; pfam14325
101510008350	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
101510008351	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
101510008352	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
101510008353	heme binding pocket [chemical binding]; other site
101510008354	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
101510008355	domain interactions; other site
101510008356	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
101510008357	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
101510008358	putative di-iron ligands [ion binding]; other site
101510008359	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
101510008360	oxidoreductase; Provisional; Region: PRK06196
101510008361	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
101510008362	putative NAD(P) binding site [chemical binding]; other site
101510008363	active site
101510008364	Domain of unknown function DUF222; Region: DUF222; pfam02720
101510008365	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
101510008366	active site
101510008367	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
101510008368	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267
101510008369	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
101510008370	replicative DNA helicase; Region: DnaB; TIGR00665
101510008371	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
101510008372	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
101510008373	Walker A motif; other site
101510008374	ATP binding site [chemical binding]; other site
101510008375	Walker B motif; other site
101510008376	DNA binding loops [nucleotide binding]
101510008377	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
101510008378	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
101510008379	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
101510008380	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
101510008381	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
101510008382	dimer interface [polypeptide binding]; other site
101510008383	ssDNA binding site [nucleotide binding]; other site
101510008384	tetramer (dimer of dimers) interface [polypeptide binding]; other site
101510008385	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
101510008386	Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
101510008387	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
101510008388	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
101510008389	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510008390	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
101510008391	substrate binding pocket [chemical binding]; other site
101510008392	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
101510008393	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510008394	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
101510008395	TPR motif; other site
101510008396	binding surface
101510008397	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510008398	DNA binding residues [nucleotide binding]
101510008399	dimerization interface [polypeptide binding]; other site
101510008400	Interferon-induced transmembrane protein; Region: CD225; pfam04505
101510008401	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
101510008402	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
101510008403	Transglycosylase; Region: Transgly; cl07896
101510008404	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
101510008405	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
101510008406	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
101510008407	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
101510008408	Helix-turn-helix domains; Region: HTH; cl00088
101510008409	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
101510008410	Transglycosylase; Region: Transgly; cl07896
101510008411	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
101510008412	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
101510008413	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
101510008414	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510008415	dimer interface [polypeptide binding]; other site
101510008416	conserved gate region; other site
101510008417	putative PBP binding loops; other site
101510008418	ABC-ATPase subunit interface; other site
101510008419	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
101510008420	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510008421	dimer interface [polypeptide binding]; other site
101510008422	conserved gate region; other site
101510008423	putative PBP binding loops; other site
101510008424	ABC-ATPase subunit interface; other site
101510008425	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
101510008426	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
101510008427	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
101510008428	Walker A/P-loop; other site
101510008429	ATP binding site [chemical binding]; other site
101510008430	Q-loop/lid; other site
101510008431	ABC transporter signature motif; other site
101510008432	Walker B; other site
101510008433	D-loop; other site
101510008434	H-loop/switch region; other site
101510008435	TOBE domain; Region: TOBE_2; cl01440
101510008436	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
101510008437	putative dimer interface [polypeptide binding]; other site
101510008438	putative [2Fe-2S] cluster binding site [ion binding]; other site
101510008439	iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411
101510008440	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
101510008441	siderophore binding site; other site
101510008442	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
101510008443	Domain of unknown function (DUF385); Region: DUF385; cl04387
101510008444	probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856
101510008445	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510008446	acetyl-CoA acetyltransferase; Provisional; Region: PRK07851
101510008447	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
101510008448	dimer interface [polypeptide binding]; other site
101510008449	active site
101510008450	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
101510008451	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510008452	Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077
101510008453	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
101510008454	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510008455	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510008456	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
101510008457	EamA-like transporter family; Region: EamA; cl01037
101510008458	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
101510008459	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510008460	active site
101510008461	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510008462	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
101510008463	Helix-turn-helix domains; Region: HTH; cl00088
101510008464	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
101510008465	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
101510008466	substrate binding pocket [chemical binding]; other site
101510008467	membrane-bound complex binding site; other site
101510008468	hinge residues; other site
101510008469	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
101510008470	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510008471	dimer interface [polypeptide binding]; other site
101510008472	conserved gate region; other site
101510008473	putative PBP binding loops; other site
101510008474	ABC-ATPase subunit interface; other site
101510008475	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
101510008476	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
101510008477	Walker A/P-loop; other site
101510008478	ATP binding site [chemical binding]; other site
101510008479	Q-loop/lid; other site
101510008480	ABC transporter signature motif; other site
101510008481	Walker B; other site
101510008482	D-loop; other site
101510008483	H-loop/switch region; other site
101510008484	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
101510008485	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
101510008486	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
101510008487	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
101510008488	LamB/YcsF family; Region: LamB_YcsF; cl00664
101510008489	Protein of unknown function (DUF1445); Region: DUF1445; cl01790
101510008490	benzoate transport; Region: 2A0115; TIGR00895
101510008491	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510008492	putative substrate translocation pore; other site
101510008493	Transcriptional regulators [Transcription]; Region: GntR; COG1802
101510008494	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510008495	DNA-binding site [nucleotide binding]; DNA binding site
101510008496	FCD domain; Region: FCD; cl11656
101510008497	Transcriptional regulators [Transcription]; Region: FadR; COG2186
101510008498	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510008499	DNA-binding site [nucleotide binding]; DNA binding site
101510008500	FCD domain; Region: FCD; cl11656
101510008501	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
101510008502	Cysteine-rich domain; Region: CCG; pfam02754
101510008503	Cysteine-rich domain; Region: CCG; pfam02754
101510008504	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
101510008505	Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674
101510008506	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
101510008507	Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674
101510008508	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510008509	hypothetical protein; Provisional; Region: PRK07945
101510008510	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
101510008511	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
101510008512	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510008513	NAD(P) binding site [chemical binding]; other site
101510008514	active site
101510008515	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
101510008516	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
101510008517	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
101510008518	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668
101510008519	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
101510008520	putative hydrophobic ligand binding site [chemical binding]; other site
101510008521	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
101510008522	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
101510008523	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
101510008524	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
101510008525	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
101510008526	catalytic loop [active]
101510008527	iron binding site [ion binding]; other site
101510008528	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
101510008529	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
101510008530	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390
101510008531	Permease family; Region: Xan_ur_permease; cl00967
101510008532	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
101510008533	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
101510008534	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
101510008535	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
101510008536	CoA-transferase family III; Region: CoA_transf_3; pfam02515
101510008537	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
101510008538	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
101510008539	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510008540	Major Facilitator Superfamily; Region: MFS_1; pfam07690
101510008541	putative substrate translocation pore; other site
101510008542	prolyl-tRNA synthetase; Provisional; Region: PRK08661
101510008543	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_arch_euk; cd00778
101510008544	dimer interface [polypeptide binding]; other site
101510008545	motif 1; other site
101510008546	active site
101510008547	motif 2; other site
101510008548	motif 3; other site
101510008549	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
101510008550	anticodon binding site; other site
101510008551	zinc-binding site [ion binding]; other site
101510008552	Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829
101510008553	active site
101510008554	putative catalytic site [active]
101510008555	Protein of unknown function (DUF3494); Region: DUF3494; pfam11999
101510008556	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
101510008557	DNA binding residues [nucleotide binding]
101510008558	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
101510008559	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
101510008560	DinB superfamily; Region: DinB_2; cl00986
101510008561	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510008562	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510008563	Helix-turn-helix domains; Region: HTH; cl00088
101510008564	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
101510008565	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
101510008566	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
101510008567	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358
101510008568	Uncharacterized conserved protein [Function unknown]; Region: COG2128
101510008569	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
101510008570	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
101510008571	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
101510008572	Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788
101510008573	DNA binding residues [nucleotide binding]
101510008574	putative dimer interface [polypeptide binding]; other site
101510008575	Gas vesicle protein; Region: Gas_vesicle; cl02954
101510008576	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
101510008577	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
101510008578	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
101510008579	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510008580	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
101510008581	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
101510008582	homodimer interface [polypeptide binding]; other site
101510008583	active site
101510008584	TDP-binding site; other site
101510008585	acceptor substrate-binding pocket; other site
101510008586	Protein of unknown function (DUF1345); Region: DUF1345; cl01753
101510008587	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599
101510008588	active site
101510008589	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
101510008590	Arginase family; Region: Arginase; cl00306
101510008591	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
101510008592	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
101510008593	non-specific DNA binding site [nucleotide binding]; other site
101510008594	salt bridge; other site
101510008595	sequence-specific DNA binding site [nucleotide binding]; other site
101510008596	Cupin domain; Region: Cupin_2; cl09118
101510008597	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
101510008598	Amino acid permease; Region: AA_permease; cl00524
101510008599	Predicted amidohydrolase [General function prediction only]; Region: COG0388
101510008600	Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576
101510008601	putative active site [active]
101510008602	catalytic triad [active]
101510008603	putative dimer interface [polypeptide binding]; other site
101510008604	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510008605	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
101510008606	Transposase domain (DUF772); Region: DUF772; cl12084
101510008607	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
101510008608	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
101510008609	Leucine carboxyl methyltransferase; Region: LCM; cl01306
101510008610	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
101510008611	metal-binding site [ion binding]
101510008612	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
101510008613	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
101510008614	metal-binding site [ion binding]
101510008615	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
101510008616	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
101510008617	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
101510008618	putative homotetramer interface [polypeptide binding]; other site
101510008619	putative homodimer interface [polypeptide binding]; other site
101510008620	putative allosteric switch controlling residues; other site
101510008621	putative metal binding site [ion binding]; other site
101510008622	putative homodimer-homodimer interface [polypeptide binding]; other site
101510008623	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
101510008624	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
101510008625	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
101510008626	motif II; other site
101510008627	FAD-dependent oxidoreductase; Provisional; Region: PRK08132
101510008628	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510008629	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510008630	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
101510008631	Transcriptional regulator [Transcription]; Region: LysR; COG0583
101510008632	Helix-turn-helix domains; Region: HTH; cl00088
101510008633	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
101510008634	putative dimerization interface [polypeptide binding]; other site
101510008635	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
101510008636	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
101510008637	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
101510008638	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
101510008639	hypothetical protein; Provisional; Region: PRK06541
101510008640	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
101510008641	inhibitor-cofactor binding pocket; inhibition site
101510008642	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510008643	catalytic residue [active]
101510008644	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
101510008645	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
101510008646	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510008647	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
101510008648	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510008649	DNA-binding site [nucleotide binding]; DNA binding site
101510008650	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
101510008651	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510008652	homodimer interface [polypeptide binding]; other site
101510008653	catalytic residue [active]
101510008654	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
101510008655	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
101510008656	Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
101510008657	formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
101510008658	NAD binding site [chemical binding]; other site
101510008659	catalytic Zn binding site [ion binding]; other site
101510008660	structural Zn binding site [ion binding]; other site
101510008661	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
101510008662	proposed catalytic triad [active]
101510008663	conserved cys residue [active]
101510008664	Domain of unknown function (DUF336); Region: DUF336; cl01249
101510008665	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
101510008666	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
101510008667	succinate CoA transferases; Region: YgfH_subfam; TIGR03458
101510008668	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364
101510008669	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
101510008670	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
101510008671	PAS fold; Region: PAS_3; pfam08447
101510008672	putative active site [active]
101510008673	heme pocket [chemical binding]; other site
101510008674	ANTAR domain; Region: ANTAR; cl04297
101510008675	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
101510008676	DNA binding residues [nucleotide binding]
101510008677	putative dimer interface [polypeptide binding]; other site
101510008678	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
101510008679	putative dimer interface [polypeptide binding]; other site
101510008680	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
101510008681	HSP70 interaction site [polypeptide binding]; other site
101510008682	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
101510008683	nitrate reductase [NADPH]; Region: PLN02252
101510008684	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200
101510008685	GAF domain; Region: GAF; cl00853
101510008686	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
101510008687	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
101510008688	active site
101510008689	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
101510008690	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
101510008691	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
101510008692	anti sigma factor interaction site; other site
101510008693	regulatory phosphorylation site [posttranslational modification]; other site
101510008694	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
101510008695	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
101510008696	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
101510008697	active site
101510008698	Sodium:solute symporter family; Region: SSF; cl00456
101510008699	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
101510008700	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
101510008701	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
101510008702	sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525
101510008703	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
101510008704	PYR/PP interface [polypeptide binding]; other site
101510008705	dimer interface [polypeptide binding]; other site
101510008706	TPP binding site [chemical binding]; other site
101510008707	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
101510008708	Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of proteins similar to Alcaligenes defragrans sulfoacetaldehyde acetyltransferase (Xsc). Xsc plays a key role in the degradation of taurine, catalyzing the...; Region: TPP_Xsc_like; cd02013
101510008709	TPP-binding site; other site
101510008710	Helix-turn-helix domains; Region: HTH; cl00088
101510008711	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510008712	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
101510008713	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
101510008714	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
101510008715	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
101510008716	metal ion-dependent adhesion site (MIDAS); other site
101510008717	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
101510008718	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
101510008719	motif II; other site
101510008720	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
101510008721	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
101510008722	active site
101510008723	multimer interface [polypeptide binding]; other site
101510008724	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
101510008725	Amino acid permease; Region: AA_permease; cl00524
101510008726	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
101510008727	Amino acid permease; Region: AA_permease; cl00524
101510008728	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
101510008729	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
101510008730	substrate binding pocket [chemical binding]; other site
101510008731	membrane-bound complex binding site; other site
101510008732	hinge residues; other site
101510008733	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510008734	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510008735	active site
101510008736	ATP binding site [chemical binding]; other site
101510008737	substrate binding site [chemical binding]; other site
101510008738	activation loop (A-loop); other site
101510008739	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
101510008740	ThiS interaction site; other site
101510008741	putative active site [active]
101510008742	tetramer interface [polypeptide binding]; other site
101510008743	hypothetical protein; Provisional; Region: PRK07945
101510008744	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
101510008745	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
101510008746	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
101510008747	Helix-turn-helix domains; Region: HTH; cl00088
101510008748	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
101510008749	dimerization interface [polypeptide binding]; other site
101510008750	LysE type translocator; Region: LysE; cl00565
101510008751	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
101510008752	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
101510008753	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510008754	NAD(P) binding site [chemical binding]; other site
101510008755	active site
101510008756	mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583
101510008757	DinB superfamily; Region: DinB_2; cl00986
101510008758	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510008759	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510008760	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
101510008761	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510008762	DNA-binding site [nucleotide binding]; DNA binding site
101510008763	UTRA domain; Region: UTRA; cl01230
101510008764	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
101510008765	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
101510008766	motif II; other site
101510008767	FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed
101510008768	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510008769	CAAX amino terminal protease self- immunity; Region: Abi; cl00558
101510008770	ketosteroid isomerase: Many biological reactions proceed by enzymatic cleavage of a C-H bond adjacent to carbonyl or a carboxyl group, leading to an enol or a enolate intermediate that is subsequently re-protonated at the same or an adjacent carbon; Region: ketosteroid_isomerase; cd00781
101510008771	dimer interface [polypeptide binding]; other site
101510008772	active site/substrate binding site [active]
101510008773	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
101510008774	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510008775	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510008776	enoyl-CoA hydratase; Provisional; Region: PRK08138
101510008777	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510008778	substrate binding site [chemical binding]; other site
101510008779	oxyanion hole (OAH) forming residues; other site
101510008780	trimer interface [polypeptide binding]; other site
101510008781	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510008782	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
101510008783	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
101510008784	active site
101510008785	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
101510008786	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510008787	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510008788	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510008789	NAD(P) binding site [chemical binding]; other site
101510008790	active site
101510008791	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
101510008792	Helix-turn-helix domains; Region: HTH; cl00088
101510008793	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
101510008794	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
101510008795	HIGH motif; other site
101510008796	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
101510008797	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
101510008798	active site
101510008799	KMSKS motif; other site
101510008800	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
101510008801	tRNA binding surface [nucleotide binding]; other site
101510008802	anticodon binding site; other site
101510008803	SdpI/YhfL protein family; Region: SdpI; pfam13630
101510008804	Protein of unknown function (DUF1648); Region: DUF1648; cl01712
101510008805	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510008806	DNA-binding site [nucleotide binding]; DNA binding site
101510008807	FCD domain; Region: FCD; cl11656
101510008808	Membrane transport protein; Region: Mem_trans; cl09117
101510008809	Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136
101510008810	Protein of unknown function DUF82; Region: DUF82; pfam01927
101510008811	Uncharacterized ACR, COG1678; Region: DUF179; cl00731
101510008812	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
101510008813	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510008814	NAD(P) binding site [chemical binding]; other site
101510008815	active site
101510008816	H+ Antiporter protein; Region: 2A0121; TIGR00900
101510008817	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
101510008818	CoenzymeA binding site [chemical binding]; other site
101510008819	subunit interaction site [polypeptide binding]; other site
101510008820	PHB binding site; other site
101510008821	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
101510008822	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
101510008823	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510008824	Walker A/P-loop; other site
101510008825	ATP binding site [chemical binding]; other site
101510008826	Q-loop/lid; other site
101510008827	ABC transporter signature motif; other site
101510008828	Walker B; other site
101510008829	D-loop; other site
101510008830	H-loop/switch region; other site
101510008831	TOBE domain; Region: TOBE_2; cl01440
101510008832	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
101510008833	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510008834	putative PBP binding loops; other site
101510008835	ABC-ATPase subunit interface; other site
101510008836	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
101510008837	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
101510008838	DNA binding residues [nucleotide binding]
101510008839	TOBE domain; Region: TOBE_2; cl01440
101510008840	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
101510008841	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
101510008842	[4Fe-4S] binding site [ion binding]; other site
101510008843	molybdopterin cofactor binding site; other site
101510008844	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
101510008845	molybdopterin cofactor binding site; other site
101510008846	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
101510008847	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
101510008848	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
101510008849	FAD binding pocket [chemical binding]; other site
101510008850	FAD binding motif [chemical binding]; other site
101510008851	catalytic residues [active]
101510008852	NAD binding pocket [chemical binding]; other site
101510008853	phosphate binding motif [ion binding]; other site
101510008854	beta-alpha-beta structure motif; other site
101510008855	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
101510008856	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
101510008857	active site
101510008858	NTP binding site [chemical binding]; other site
101510008859	metal binding triad [ion binding]; metal-binding site
101510008860	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
101510008861	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
101510008862	Zn2+ binding site [ion binding]; other site
101510008863	Mg2+ binding site [ion binding]; other site
101510008864	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
101510008865	active site
101510008866	Ap6A binding site [chemical binding]; other site
101510008867	nudix motif; other site
101510008868	metal binding site [ion binding]; metal-binding site
101510008869	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
101510008870	RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643
101510008871	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
101510008872	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
101510008873	DNA binding residues [nucleotide binding]
101510008874	Helix-turn-helix domains; Region: HTH; cl00088
101510008875	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
101510008876	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510008877	NAD(P) binding site [chemical binding]; other site
101510008878	active site
101510008879	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
101510008880	active site
101510008881	FMN binding site [chemical binding]; other site
101510008882	substrate binding site [chemical binding]; other site
101510008883	putative catalytic residue [active]
101510008884	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
101510008885	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510008886	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
101510008887	catalytic residues [active]
101510008888	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
101510008889	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
101510008890	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
101510008891	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
101510008892	active site
101510008893	metal binding site [ion binding]; metal-binding site
101510008894	ParB-like partition proteins; Region: parB_part; TIGR00180
101510008895	ParB-like nuclease domain; Region: ParBc; cl02129
101510008896	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
101510008897	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
101510008898	P-loop; other site
101510008899	Magnesium ion binding site [ion binding]; other site
101510008900	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
101510008901	Magnesium ion binding site [ion binding]; other site
101510008902	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
101510008903	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510008904	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510008905	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
101510008906	G-X-X-G motif; other site
101510008907	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
101510008908	RxxxH motif; other site
101510008909	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
101510008910	Domain of unknown function DUF37; Region: DUF37; cl00506
101510008911	Ribonuclease P; Region: Ribonuclease_P; cl00457
101510008912	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
101510008913	chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086
101510008914	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
101510008915	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
101510008916	Walker A motif; other site
101510008917	ATP binding site [chemical binding]; other site
101510008918	Walker B motif; other site
101510008919	arginine finger; other site
101510008920	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
101510008921	DnaA box-binding interface [nucleotide binding]; other site
101510008922	DNA polymerase III subunit beta; Validated; Region: PRK07761
101510008923	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
101510008924	putative DNA binding surface [nucleotide binding]; other site
101510008925	dimer interface [polypeptide binding]; other site
101510008926	beta-clamp/clamp loader binding surface; other site
101510008927	beta-clamp/translesion DNA polymerase binding surface; other site
101510008928	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510008929	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490
101510008930	Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195
101510008931	RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage.  When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242
101510008932	Walker A/P-loop; other site
101510008933	ATP binding site [chemical binding]; other site
101510008934	Q-loop/lid; other site
101510008935	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510008936	ABC transporter signature motif; other site
101510008937	Walker B; other site
101510008938	D-loop; other site
101510008939	H-loop/switch region; other site
101510008940	Protein of unknown function (DUF721); Region: DUF721; cl02324
101510008941	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
101510008942	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
101510008943	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
101510008944	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
101510008945	FMN-binding pocket [chemical binding]; other site
101510008946	flavin binding motif; other site
101510008947	phosphate binding motif [ion binding]; other site
101510008948	beta-alpha-beta structure motif; other site
101510008949	NAD binding pocket [chemical binding]; other site
101510008950	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510008951	catalytic loop [active]
101510008952	iron binding site [ion binding]; other site
101510008953	short chain dehydrogenase; Validated; Region: PRK05855
101510008954	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
101510008955	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
101510008956	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
101510008957	anchoring element; other site
101510008958	dimer interface [polypeptide binding]; other site
101510008959	ATP binding site [chemical binding]; other site
101510008960	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
101510008961	active site
101510008962	putative metal-binding site [ion binding]; other site
101510008963	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
101510008964	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
101510008965	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510008966	ATP binding site [chemical binding]; other site
101510008967	Mg2+ binding site [ion binding]; other site
101510008968	G-X-G motif; other site
101510008969	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
101510008970	Protein of unknown function (DUF742); Region: DUF742; pfam05331
101510008971	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras; Region: Ras_like_GTPase; cd00882
101510008972	Switch I region; other site
101510008973	G3 box; other site
101510008974	Switch II region; other site
101510008975	GTP/Mg2+ binding site [chemical binding]; other site
101510008976	G4 box; other site
101510008977	G5 box; other site
101510008978	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
101510008979	DNA gyrase subunit A; Validated; Region: PRK05560
101510008980	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
101510008981	CAP-like domain; other site
101510008982	active site
101510008983	primary dimer interface [polypeptide binding]; other site
101510008984	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
101510008985	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
101510008986	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
101510008987	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
101510008988	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
101510008989	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
101510008990	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
101510008991	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
101510008992	FAD binding pocket [chemical binding]; other site
101510008993	FAD binding motif [chemical binding]; other site
101510008994	phosphate binding motif [ion binding]; other site
101510008995	NAD binding pocket [chemical binding]; other site
101510008996	Chorismate mutase type II; Region: CM_2; cl00693
101510008997	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
101510008998	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
101510008999	conserved cys residue [active]
101510009000	Predicted membrane protein (DUF2319); Region: DUF2319; cl15412
101510009001	peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791
101510009002	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
101510009003	active site
101510009004	Rhomboid family; Region: Rhomboid; cl11446
101510009005	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
101510009006	Uncharacterised protein family (UPF0233); Region: UPF0233; cl11506
101510009007	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
101510009008	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
101510009009	Glutamine amidotransferase class-I; Region: GATase; pfam00117
101510009010	glutamine binding [chemical binding]; other site
101510009011	catalytic triad [active]
101510009012	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
101510009013	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510009014	active site
101510009015	ATP binding site [chemical binding]; other site
101510009016	substrate binding site [chemical binding]; other site
101510009017	activation loop (A-loop); other site
101510009018	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
101510009019	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
101510009020	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
101510009021	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
101510009022	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
101510009023	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510009024	active site
101510009025	ATP binding site [chemical binding]; other site
101510009026	substrate binding site [chemical binding]; other site
101510009027	activation loop (A-loop); other site
101510009028	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
101510009029	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
101510009030	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
101510009031	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
101510009032	active site
101510009033	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
101510009034	phosphopeptide binding site; other site
101510009035	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
101510009036	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
101510009037	phosphopeptide binding site; other site
101510009038	RDD family; Region: RDD; cl00746
101510009039	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
101510009040	Mitomycin C resistance protein (MRD); Region: MRD; cd07235
101510009041	dimer interface [polypeptide binding]; other site
101510009042	ligand binding site [chemical binding]; other site
101510009043	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510009044	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
101510009045	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510009046	hypothetical protein; Provisional; Region: PRK07538
101510009047	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
101510009048	Helix-turn-helix domains; Region: HTH; cl00088
101510009049	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
101510009050	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
101510009051	active site
101510009052	dimer interface [polypeptide binding]; other site
101510009053	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
101510009054	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
101510009055	active site
101510009056	FMN binding site [chemical binding]; other site
101510009057	substrate binding site [chemical binding]; other site
101510009058	3Fe-4S cluster binding site [ion binding]; other site
101510009059	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
101510009060	domain interface; other site
101510009061	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
101510009062	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510009063	Cutinase; Region: Cutinase; cl15711
101510009064	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
101510009065	active site
101510009066	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
101510009067	hydrophobic ligand binding site; other site
101510009068	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510009069	NAD(P) binding site [chemical binding]; other site
101510009070	active site
101510009071	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
101510009072	classical (c) SDRs; Region: SDR_c; cd05233
101510009073	NAD(P) binding site [chemical binding]; other site
101510009074	active site
101510009075	DNA binding domains of BfiI, EcoRII and plant B3 proteins; Region: BfiI_C_EcoRII_N_B3; cl15242
101510009076	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
101510009077	Dienelactone hydrolase family; Region: DLH; pfam01738
101510009078	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
101510009079	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
101510009080	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
101510009081	catalytic core [active]
101510009082	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510009083	Protein of unknown function (DUF998); Region: DUF998; pfam06197
101510009084	lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983
101510009085	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
101510009086	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
101510009087	dimer interface [polypeptide binding]; other site
101510009088	putative anticodon binding site; other site
101510009089	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
101510009090	motif 1; other site
101510009091	dimer interface [polypeptide binding]; other site
101510009092	active site
101510009093	motif 2; other site
101510009094	motif 3; other site
101510009095	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
101510009096	RNA binding surface [nucleotide binding]; other site
101510009097	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
101510009098	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
101510009099	active site
101510009100	metal binding site [ion binding]; metal-binding site
101510009101	dimer interface [polypeptide binding]; other site
101510009102	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
101510009103	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
101510009104	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510009105	NAD(P) binding site [chemical binding]; other site
101510009106	active site
101510009107	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510009108	Helix-turn-helix domains; Region: HTH; cl00088
101510009109	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
101510009110	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510009111	Helix-turn-helix domains; Region: HTH; cl00088
101510009112	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
101510009113	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
101510009114	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
101510009115	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
101510009116	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
101510009117	carboxyltransferase (CT) interaction site; other site
101510009118	biotinylation site [posttranslational modification]; other site
101510009119	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
101510009120	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780
101510009121	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780
101510009122	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
101510009123	DNA binding residues [nucleotide binding]
101510009124	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
101510009125	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
101510009126	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510009127	Major Facilitator Superfamily; Region: MFS_1; pfam07690
101510009128	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510009129	putative substrate translocation pore; other site
101510009130	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
101510009131	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
101510009132	conserved cys residue [active]
101510009133	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510009134	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510009135	Membrane protein of unknown function; Region: DUF360; cl00850
101510009136	Sulfatase; Region: Sulfatase; cl10460
101510009137	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
101510009138	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
101510009139	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
101510009140	Permease family; Region: Xan_ur_permease; cl00967
101510009141	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
101510009142	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
101510009143	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
101510009144	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
101510009145	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
101510009146	motif II; other site
101510009147	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
101510009148	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510009149	active site
101510009150	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
101510009151	Short C-terminal domain; Region: SHOCT; cl01373
101510009152	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
101510009153	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
101510009154	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088
101510009155	Domain of unknown function DUF20; Region: UPF0118; cl00465
101510009156	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
101510009157	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
101510009158	Uncharacterized conserved protein [Function unknown]; Region: COG5361
101510009159	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510009160	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
101510009161	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510009162	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
101510009163	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
101510009164	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
101510009165	Predicted membrane protein (DUF2319); Region: DUF2319; cl15412
101510009166	poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240
101510009167	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
101510009168	putative active site [active]
101510009169	putative catalytic site [active]
101510009170	poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839
101510009171	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
101510009172	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
101510009173	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510009174	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
101510009175	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
101510009176	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510009177	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510009178	putative substrate translocation pore; other site
101510009179	Uncharacterized conserved protein [Function unknown]; Region: COG3246
101510009180	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
101510009181	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
101510009182	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
101510009183	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
101510009184	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
101510009185	NADP binding site [chemical binding]; other site
101510009186	dimer interface [polypeptide binding]; other site
101510009187	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
101510009188	Helix-turn-helix domains; Region: HTH; cl00088
101510009189	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
101510009190	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510009191	Siderophore biosynthesis protein domain; Region: AlcB; cl11000
101510009192	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
101510009193	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
101510009194	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510009195	putative substrate translocation pore; other site
101510009196	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510009197	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
101510009198	dimer interface [polypeptide binding]; other site
101510009199	NADP binding site [chemical binding]; other site
101510009200	catalytic residues [active]
101510009201	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
101510009202	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
101510009203	catalytic residue [active]
101510009204	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
101510009205	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
101510009206	active site
101510009207	tetramer interface [polypeptide binding]; other site
101510009208	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
101510009209	Helix-turn-helix domains; Region: HTH; cl00088
101510009210	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447
101510009211	putative dimerization interface [polypeptide binding]; other site
101510009212	putative substrate binding pocket [chemical binding]; other site
101510009213	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
101510009214	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510009215	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
101510009216	DinB superfamily; Region: DinB_2; cl00986
101510009217	putative acetyltransferase YhhY; Provisional; Region: PRK10140
101510009218	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
101510009219	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
101510009220	Coenzyme A binding pocket [chemical binding]; other site
101510009221	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
101510009222	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510009223	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510009224	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
101510009225	Walker A/P-loop; other site
101510009226	ATP binding site [chemical binding]; other site
101510009227	Q-loop/lid; other site
101510009228	ABC transporter signature motif; other site
101510009229	Walker B; other site
101510009230	D-loop; other site
101510009231	H-loop/switch region; other site
101510009232	ABC-2 type transporter; Region: ABC2_membrane; cl11417
101510009233	RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637
101510009234	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
101510009235	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358
101510009236	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
101510009237	dimerization interface [polypeptide binding]; other site
101510009238	putative DNA binding site [nucleotide binding]; other site
101510009239	putative Zn2+ binding site [ion binding]; other site
101510009240	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
101510009241	putative hydrophobic ligand binding site [chemical binding]; other site
101510009242	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
101510009243	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510009244	Carboxylesterase family; Region: COesterase; pfam00135
101510009245	substrate binding pocket [chemical binding]; other site
101510009246	catalytic triad [active]
101510009247	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
101510009248	classical (c) SDRs; Region: SDR_c; cd05233
101510009249	NAD(P) binding site [chemical binding]; other site
101510009250	active site
101510009251	Cupin domain; Region: Cupin_2; cl09118
101510009252	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
101510009253	Helix-turn-helix domains; Region: HTH; cl00088
101510009254	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
101510009255	dimerization interface [polypeptide binding]; other site
101510009256	substrate binding pocket [chemical binding]; other site
101510009257	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
101510009258	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
101510009259	substrate binding pocket [chemical binding]; other site
101510009260	membrane-bound complex binding site; other site
101510009261	hinge residues; other site
101510009262	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
101510009263	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510009264	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
101510009265	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510009266	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
101510009267	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
101510009268	active site
101510009269	Cytochrome P450; Region: p450; cl12078
101510009270	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
101510009271	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510009272	S-adenosylmethionine binding site [chemical binding]; other site
101510009273	Domain of unknown function (DUF385); Region: DUF385; cl04387
101510009274	Anti-sigma-K factor rskA; Region: RskA; cl15366
101510009275	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
101510009276	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
101510009277	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
101510009278	DNA binding residues [nucleotide binding]
101510009279	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
101510009280	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510009281	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510009282	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
101510009283	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510009284	Walker A/P-loop; other site
101510009285	ATP binding site [chemical binding]; other site
101510009286	Q-loop/lid; other site
101510009287	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
101510009288	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510009289	Walker A/P-loop; other site
101510009290	ATP binding site [chemical binding]; other site
101510009291	Q-loop/lid; other site
101510009292	ABC transporter signature motif; other site
101510009293	Walker B; other site
101510009294	D-loop; other site
101510009295	H-loop/switch region; other site
101510009296	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
101510009297	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510009298	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
101510009299	active site
101510009300	metal binding site [ion binding]; metal-binding site
101510009301	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
101510009302	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358
101510009303	YCII-related domain; Region: YCII; cl00999
101510009304	Transcription factor WhiB; Region: Whib; pfam02467
101510009305	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510009306	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510009307	NAD(P) binding site [chemical binding]; other site
101510009308	active site
101510009309	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510009310	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510009311	putative substrate translocation pore; other site
101510009312	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
101510009313	TPP-binding site [chemical binding]; other site
101510009314	dimer interface [polypeptide binding]; other site
101510009315	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
101510009316	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
101510009317	PYR/PP interface [polypeptide binding]; other site
101510009318	dimer interface [polypeptide binding]; other site
101510009319	TPP binding site [chemical binding]; other site
101510009320	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
101510009321	Transcriptional regulators [Transcription]; Region: GntR; COG1802
101510009322	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510009323	DNA-binding site [nucleotide binding]; DNA binding site
101510009324	FCD domain; Region: FCD; cl11656
101510009325	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
101510009326	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
101510009327	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
101510009328	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
101510009329	Probable transposase; Region: OrfB_IS605; pfam01385
101510009330	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
101510009331	Sodium:solute symporter family; Region: SSF; cl00456
101510009332	Transcriptional regulators [Transcription]; Region: PurR; COG1609
101510009333	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
101510009334	DNA binding site [nucleotide binding]
101510009335	domain linker motif; other site
101510009336	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
101510009337	ligand binding site [chemical binding]; other site
101510009338	dimerization interface [polypeptide binding]; other site
101510009339	Flavin Reductases; Region: FlaRed; cl00801
101510009340	Cupin domain; Region: Cupin_2; cl09118
101510009341	Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368
101510009342	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510009343	active site
101510009344	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
101510009345	Protein of unknown function (DUF2848); Region: DUF2848; pfam11010
101510009346	Predicted amidohydrolase [General function prediction only]; Region: COG0388
101510009347	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
101510009348	putative active site [active]
101510009349	catalytic triad [active]
101510009350	putative dimer interface [polypeptide binding]; other site
101510009351	Transcriptional regulators [Transcription]; Region: GntR; COG1802
101510009352	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510009353	DNA-binding site [nucleotide binding]; DNA binding site
101510009354	FCD domain; Region: FCD; cl11656
101510009355	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510009356	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510009357	putative substrate translocation pore; other site
101510009358	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
101510009359	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
101510009360	active site
101510009361	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
101510009362	Amino acid permease; Region: AA_permease; cl00524
101510009363	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510009364	Helix-turn-helix domains; Region: HTH; cl00088
101510009365	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
101510009366	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510009367	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
101510009368	N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013
101510009369	tetramer interface [polypeptide binding]; other site
101510009370	catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211
101510009371	C-terminal, catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_C_like; cd09014
101510009372	tetramer interface [polypeptide binding]; other site
101510009373	active site
101510009374	metal binding site [ion binding]; metal-binding site
101510009375	acetaldehyde dehydrogenase; Validated; Region: PRK08300
101510009376	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510009377	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
101510009378	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
101510009379	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
101510009380	active site
101510009381	catalytic residues [active]
101510009382	metal binding site [ion binding]; metal-binding site
101510009383	DmpG-like communication domain; Region: DmpG_comm; pfam07836
101510009384	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510009385	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
101510009386	NAD binding site [chemical binding]; other site
101510009387	catalytic residues [active]
101510009388	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510009389	NAD(P) binding site [chemical binding]; other site
101510009390	active site
101510009391	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
101510009392	active site 1 [active]
101510009393	dimer interface [polypeptide binding]; other site
101510009394	hexamer interface [polypeptide binding]; other site
101510009395	active site 2 [active]
101510009396	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
101510009397	active site 1 [active]
101510009398	dimer interface [polypeptide binding]; other site
101510009399	hexamer interface [polypeptide binding]; other site
101510009400	active site 2 [active]
101510009401	Flavin Reductases; Region: FlaRed; cl00801
101510009402	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310
101510009403	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
101510009404	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
101510009405	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510009406	EthD protein; Region: EthD; cl06234
101510009407	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
101510009408	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510009409	catalytic loop [active]
101510009410	iron binding site [ion binding]; other site
101510009411	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
101510009412	FAD binding pocket [chemical binding]; other site
101510009413	FAD binding motif [chemical binding]; other site
101510009414	phosphate binding motif [ion binding]; other site
101510009415	beta-alpha-beta structure motif; other site
101510009416	NAD binding pocket [chemical binding]; other site
101510009417	Cytochrome P450; Region: p450; cl12078
101510009418	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
101510009419	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510009420	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510009421	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510009422	active site
101510009423	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
101510009424	active site 1 [active]
101510009425	dimer interface [polypeptide binding]; other site
101510009426	hexamer interface [polypeptide binding]; other site
101510009427	active site 2 [active]
101510009428	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
101510009429	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
101510009430	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510009431	Helix-turn-helix domains; Region: HTH; cl00088
101510009432	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510009433	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
101510009434	putative metal binding site [ion binding]; other site
101510009435	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510009436	active site
101510009437	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
101510009438	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510009439	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
101510009440	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510009441	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
101510009442	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
101510009443	Ligand Binding Site [chemical binding]; other site
101510009444	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
101510009445	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510009446	putative substrate translocation pore; other site
101510009447	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510009448	Helix-turn-helix domains; Region: HTH; cl00088
101510009449	enoyl-CoA hydratase; Provisional; Region: PRK06213
101510009450	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510009451	substrate binding site [chemical binding]; other site
101510009452	oxyanion hole (OAH) forming residues; other site
101510009453	trimer interface [polypeptide binding]; other site
101510009454	putative acyltransferase; Provisional; Region: PRK05790
101510009455	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
101510009456	dimer interface [polypeptide binding]; other site
101510009457	active site
101510009458	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
101510009459	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
101510009460	Helix-turn-helix domains; Region: HTH; cl00088
101510009461	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510009462	YceI-like domain; Region: YceI; cl01001
101510009463	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
101510009464	Helix-turn-helix domains; Region: HTH; cl00088
101510009465	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
101510009466	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510009467	Zn binding site [ion binding]; other site
101510009468	Cupin domain; Region: Cupin_2; cl09118
101510009469	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
101510009470	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
101510009471	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510009472	Helix-turn-helix domains; Region: HTH; cl00088
101510009473	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510009474	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
101510009475	substrate binding pocket [chemical binding]; other site
101510009476	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510009477	Cupin domain; Region: Cupin_2; cl09118
101510009478	Cupin domain; Region: Cupin_2; cl09118
101510009479	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510009480	DNA-binding site [nucleotide binding]; DNA binding site
101510009481	FCD domain; Region: FCD; cl11656
101510009482	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510009483	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
101510009484	hypothetical protein; Provisional; Region: PRK06126
101510009485	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510009486	Protein of unknown function (DUF3500); Region: DUF3500; pfam12006
101510009487	Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to  the...; Region: intradiol_dioxygenase_like; cd03457
101510009488	putative active site [active]
101510009489	Transcriptional regulator [Transcription]; Region: LysR; COG0583
101510009490	Helix-turn-helix domains; Region: HTH; cl00088
101510009491	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
101510009492	putative dimerization interface [polypeptide binding]; other site
101510009493	EamA-like transporter family; Region: EamA; cl01037
101510009494	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
101510009495	metal binding site [ion binding]; metal-binding site
101510009496	active site
101510009497	I-site; other site
101510009498	Predicted amidohydrolase [General function prediction only]; Region: COG0388
101510009499	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
101510009500	active site
101510009501	catalytic triad [active]
101510009502	dimer interface [polypeptide binding]; other site
101510009503	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
101510009504	Amino acid permease; Region: AA_permease; cl00524
101510009505	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
101510009506	Helix-turn-helix domains; Region: HTH; cl00088
101510009507	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
101510009508	FMN binding site [chemical binding]; other site
101510009509	active site
101510009510	substrate binding site [chemical binding]; other site
101510009511	catalytic residue [active]
101510009512	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
101510009513	Ligand Binding Site [chemical binding]; other site
101510009514	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
101510009515	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510009516	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
101510009517	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_12; cd08491
101510009518	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
101510009519	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510009520	dimer interface [polypeptide binding]; other site
101510009521	conserved gate region; other site
101510009522	putative PBP binding loops; other site
101510009523	ABC-ATPase subunit interface; other site
101510009524	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
101510009525	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510009526	dimer interface [polypeptide binding]; other site
101510009527	conserved gate region; other site
101510009528	putative PBP binding loops; other site
101510009529	ABC-ATPase subunit interface; other site
101510009530	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
101510009531	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
101510009532	Walker A/P-loop; other site
101510009533	ATP binding site [chemical binding]; other site
101510009534	Q-loop/lid; other site
101510009535	ABC transporter signature motif; other site
101510009536	Walker B; other site
101510009537	D-loop; other site
101510009538	H-loop/switch region; other site
101510009539	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
101510009540	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
101510009541	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
101510009542	Walker A/P-loop; other site
101510009543	ATP binding site [chemical binding]; other site
101510009544	Q-loop/lid; other site
101510009545	ABC transporter signature motif; other site
101510009546	Walker B; other site
101510009547	D-loop; other site
101510009548	H-loop/switch region; other site
101510009549	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
101510009550	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
101510009551	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
101510009552	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
101510009553	active site
101510009554	tetramer interface [polypeptide binding]; other site
101510009555	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510009556	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
101510009557	5-methylcytosine-specific restriction enzyme subunit McrB; Provisional; Region: PRK11331
101510009558	Walker A motif; other site
101510009559	ATP binding site [chemical binding]; other site
101510009560	Low affinity iron permease; Region: Iron_permease; cl12096
101510009561	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510009562	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101
101510009563	NAD(P) binding site [chemical binding]; other site
101510009564	catalytic residues [active]
101510009565	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
101510009566	hydrophobic ligand binding site; other site
101510009567	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510009568	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786
101510009569	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510009570	enoyl-CoA hydratase; Provisional; Region: PRK06688
101510009571	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510009572	substrate binding site [chemical binding]; other site
101510009573	oxyanion hole (OAH) forming residues; other site
101510009574	trimer interface [polypeptide binding]; other site
101510009575	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
101510009576	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
101510009577	NAD(P) binding site [chemical binding]; other site
101510009578	enoyl-CoA hydratase; Provisional; Region: PRK08252
101510009579	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510009580	substrate binding site [chemical binding]; other site
101510009581	oxyanion hole (OAH) forming residues; other site
101510009582	trimer interface [polypeptide binding]; other site
101510009583	acetyl-CoA acetyltransferase; Provisional; Region: PRK06504
101510009584	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
101510009585	dimer interface [polypeptide binding]; other site
101510009586	active site
101510009587	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
101510009588	NAD binding site [chemical binding]; other site
101510009589	homotetramer interface [polypeptide binding]; other site
101510009590	homodimer interface [polypeptide binding]; other site
101510009591	active site
101510009592	Helix-turn-helix domains; Region: HTH; cl00088
101510009593	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510009594	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510009595	active site
101510009596	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
101510009597	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
101510009598	FMN binding site [chemical binding]; other site
101510009599	substrate binding site [chemical binding]; other site
101510009600	putative catalytic residue [active]
101510009601	enoyl-CoA hydratase; Provisional; Region: PRK08260
101510009602	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510009603	substrate binding site [chemical binding]; other site
101510009604	oxyanion hole (OAH) forming residues; other site
101510009605	trimer interface [polypeptide binding]; other site
101510009606	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510009607	Helix-turn-helix domains; Region: HTH; cl00088
101510009608	Protein of unknown function (DUF1696); Region: DUF1696; pfam08000
101510009609	Major Facilitator Superfamily; Region: MFS_1; pfam07690
101510009610	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510009611	putative substrate translocation pore; other site
101510009612	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
101510009613	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510009614	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510009615	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510009616	putative substrate translocation pore; other site
101510009617	Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173
101510009618	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
101510009619	putative active site [active]
101510009620	putative substrate binding site [chemical binding]; other site
101510009621	ATP binding site [chemical binding]; other site
101510009622	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510009623	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510009624	active site
101510009625	acyl-CoA synthetase; Validated; Region: PRK08316
101510009626	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510009627	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510009628	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510009629	putative substrate translocation pore; other site
101510009630	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510009631	cyclase homology domain; Region: CHD; cd07302
101510009632	nucleotidyl binding site; other site
101510009633	metal binding site [ion binding]; metal-binding site
101510009634	dimer interface [polypeptide binding]; other site
101510009635	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
101510009636	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510009637	active site
101510009638	phosphorylation site [posttranslational modification]
101510009639	intermolecular recognition site; other site
101510009640	dimerization interface [polypeptide binding]; other site
101510009641	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510009642	DNA binding residues [nucleotide binding]
101510009643	dimerization interface [polypeptide binding]; other site
101510009644	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
101510009645	Histidine kinase; Region: HisKA_3; pfam07730
101510009646	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510009647	ATP binding site [chemical binding]; other site
101510009648	Mg2+ binding site [ion binding]; other site
101510009649	G-X-G motif; other site
101510009650	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
101510009651	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
101510009652	Walker A/P-loop; other site
101510009653	ATP binding site [chemical binding]; other site
101510009654	Q-loop/lid; other site
101510009655	ABC transporter signature motif; other site
101510009656	Walker B; other site
101510009657	D-loop; other site
101510009658	H-loop/switch region; other site
101510009659	benzoate transport; Region: 2A0115; TIGR00895
101510009660	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510009661	putative substrate translocation pore; other site
101510009662	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510009663	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510009664	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
101510009665	NAD(P) binding site [chemical binding]; other site
101510009666	catalytic residues [active]
101510009667	3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295
101510009668	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
101510009669	active site
101510009670	metal binding site [ion binding]; metal-binding site
101510009671	C-terminal, catalytic, domain of BphC5 (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacterium Rhodococcus rhodochrous K37 and similar proteins; Region: BphC5-RK37_C_like; cd07239
101510009672	putative active site [active]
101510009673	Mn binding site [ion binding]; other site
101510009674	putative oligomer interface [polypeptide binding]; other site
101510009675	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
101510009676	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510009677	Cupin domain; Region: Cupin_2; cl09118
101510009678	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
101510009679	classical (c) SDRs; Region: SDR_c; cd05233
101510009680	NAD(P) binding site [chemical binding]; other site
101510009681	active site
101510009682	short chain dehydrogenase; Provisional; Region: PRK07062
101510009683	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
101510009684	putative NAD(P) binding site [chemical binding]; other site
101510009685	putative active site [active]
101510009686	hypothetical protein; Provisional; Region: PRK07064
101510009687	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
101510009688	PYR/PP interface [polypeptide binding]; other site
101510009689	dimer interface [polypeptide binding]; other site
101510009690	TPP binding site [chemical binding]; other site
101510009691	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
101510009692	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
101510009693	TPP-binding site [chemical binding]; other site
101510009694	salicylate hydroxylase; Provisional; Region: PRK06475
101510009695	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510009696	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510009697	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
101510009698	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
101510009699	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
101510009700	FMN-binding pocket [chemical binding]; other site
101510009701	flavin binding motif; other site
101510009702	phosphate binding motif [ion binding]; other site
101510009703	beta-alpha-beta structure motif; other site
101510009704	NAD binding pocket [chemical binding]; other site
101510009705	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510009706	catalytic loop [active]
101510009707	iron binding site [ion binding]; other site
101510009708	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
101510009709	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
101510009710	iron-sulfur cluster [ion binding]; other site
101510009711	[2Fe-2S] cluster binding site [ion binding]; other site
101510009712	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
101510009713	hydrophobic ligand binding site; other site
101510009714	Helix-turn-helix domains; Region: HTH; cl00088
101510009715	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
101510009716	homotrimer interaction site [polypeptide binding]; other site
101510009717	putative active site [active]
101510009718	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
101510009719	Fe-S cluster binding site [ion binding]; other site
101510009720	active site
101510009721	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
101510009722	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
101510009723	putative NAD(P) binding site [chemical binding]; other site
101510009724	Transposase domain (DUF772); Region: DUF772; cl12084
101510009725	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
101510009726	Copper resistance protein D; Region: CopD; cl00563
101510009727	Copper resistance protein CopC; Region: CopC; cl01012
101510009728	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
101510009729	RecB family nuclease, putative, TM0106 family; Region: TIGR03491
101510009730	Protein of unknown function (DUF1275); Region: DUF1275; cl01453
101510009731	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510009732	S-adenosylmethionine binding site [chemical binding]; other site
101510009733	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510009734	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510009735	NAD(P) binding site [chemical binding]; other site
101510009736	active site
101510009737	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; cl09957
101510009738	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
101510009739	ligand binding site [chemical binding]; other site
101510009740	flexible hinge region; other site
101510009741	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510009742	ATP binding site [chemical binding]; other site
101510009743	Mg2+ binding site [ion binding]; other site
101510009744	G-X-G motif; other site
101510009745	Response regulator receiver domain; Region: Response_reg; pfam00072
101510009746	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510009747	active site
101510009748	phosphorylation site [posttranslational modification]
101510009749	intermolecular recognition site; other site
101510009750	dimerization interface [polypeptide binding]; other site
101510009751	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
101510009752	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510009753	Predicted membrane protein [Function unknown]; Region: COG2119
101510009754	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
101510009755	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
101510009756	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
101510009757	amidase; Provisional; Region: PRK07869
101510009758	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
101510009759	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
101510009760	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
101510009761	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
101510009762	OpgC protein; Region: OpgC_C; cl00792
101510009763	Acyltransferase family; Region: Acyl_transf_3; pfam01757
101510009764	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
101510009765	Domain of unknown function (DUF1772); Region: DUF1772; cl12097
101510009766	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510009767	NAD(P) binding site [chemical binding]; other site
101510009768	active site
101510009769	Cupin domain; Region: Cupin_2; cl09118
101510009770	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
101510009771	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510009772	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510009773	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
101510009774	homotrimer interaction site [polypeptide binding]; other site
101510009775	putative active site [active]
101510009776	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
101510009777	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510009778	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
101510009779	tandem repeat interface [polypeptide binding]; other site
101510009780	oligomer interface [polypeptide binding]; other site
101510009781	active site residues [active]
101510009782	Domain of unknown function (DUF4328); Region: DUF4328; pfam14219
101510009783	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
101510009784	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
101510009785	active site
101510009786	catalytic site [active]
101510009787	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
101510009788	Ferritin-like domain; Region: Ferritin; pfam00210
101510009789	ferroxidase diiron center [ion binding]; other site
101510009790	Secretory lipase; Region: LIP; pfam03583
101510009791	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
101510009792	Ferritin-like domain; Region: Ferritin; pfam00210
101510009793	ferroxidase diiron center [ion binding]; other site
101510009794	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
101510009795	CAAX amino terminal protease self- immunity; Region: Abi; cl00558
101510009796	prephenate dehydratase; Provisional; Region: PRK11898
101510009797	Prephenate dehydratase; Region: PDT; pfam00800
101510009798	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
101510009799	putative L-Phe binding site [chemical binding]; other site
101510009800	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
101510009801	catalytic core [active]
101510009802	Protein of unknown function (DUF1222); Region: DUF1222; pfam06762
101510009803	EspG family; Region: ESX-1_EspG; pfam14011
101510009804	PPE family; Region: PPE; pfam00823
101510009805	Possibl zinc metallo-peptidase; Region: DUF1025; cl01577
101510009806	Septum formation; Region: Septum_form; pfam13845
101510009807	Septum formation; Region: Septum_form; pfam13845
101510009808	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
101510009809	seryl-tRNA synthetase; Provisional; Region: PRK05431
101510009810	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
101510009811	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770
101510009812	dimer interface [polypeptide binding]; other site
101510009813	active site
101510009814	motif 1; other site
101510009815	motif 2; other site
101510009816	motif 3; other site
101510009817	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
101510009818	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
101510009819	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
101510009820	heme binding site [chemical binding]; other site
101510009821	ferroxidase pore; other site
101510009822	ferroxidase diiron center [ion binding]; other site
101510009823	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510009824	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
101510009825	iron-sulfur cluster [ion binding]; other site
101510009826	[2Fe-2S] cluster binding site [ion binding]; other site
101510009827	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
101510009828	putative acyl-acceptor binding pocket; other site
101510009829	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
101510009830	putative acyl-acceptor binding pocket; other site
101510009831	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
101510009832	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
101510009833	active site
101510009834	motif I; other site
101510009835	motif II; other site
101510009836	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
101510009837	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
101510009838	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
101510009839	amidase catalytic site [active]
101510009840	Zn binding residues [ion binding]; other site
101510009841	substrate binding site [chemical binding]; other site
101510009842	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
101510009843	LGFP repeat; Region: LGFP; pfam08310
101510009844	Stage II sporulation protein; Region: SpoIID; pfam08486
101510009845	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
101510009846	LGFP repeat; Region: LGFP; pfam08310
101510009847	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
101510009848	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
101510009849	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510009850	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510009851	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
101510009852	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
101510009853	UbiA prenyltransferase family; Region: UbiA; cl00337
101510009854	Predicted esterase [General function prediction only]; Region: COG0627
101510009855	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510009856	Predicted esterase [General function prediction only]; Region: COG0627
101510009857	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510009858	Predicted esterase [General function prediction only]; Region: COG0627
101510009859	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510009860	LGFP repeat; Region: LGFP; pfam08310
101510009861	LGFP repeat; Region: LGFP; pfam08310
101510009862	LGFP repeat; Region: LGFP; pfam08310
101510009863	Cutinase; Region: Cutinase; cl15711
101510009864	probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621
101510009865	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510009866	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
101510009867	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510009868	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510009869	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
101510009870	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
101510009871	active site
101510009872	Acyl transferase domain; Region: Acyl_transf_1; cl08282
101510009873	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510009874	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
101510009875	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
101510009876	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780
101510009877	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
101510009878	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
101510009879	Transposase domain (DUF772); Region: DUF772; cl12084
101510009880	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
101510009881	Helix-turn-helix domains; Region: HTH; cl00088
101510009882	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
101510009883	active site
101510009884	MspA; Region: MspA; pfam09203
101510009885	Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250
101510009886	Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249
101510009887	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
101510009888	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510009889	NAD(P) binding site [chemical binding]; other site
101510009890	active site
101510009891	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
101510009892	FAD binding domain; Region: FAD_binding_4; pfam01565
101510009893	D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370
101510009894	GtrA-like protein; Region: GtrA; cl00971
101510009895	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510009896	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
101510009897	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
101510009898	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
101510009899	protein binding site [polypeptide binding]; other site
101510009900	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
101510009901	Transcriptional regulators [Transcription]; Region: PurR; COG1609
101510009902	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
101510009903	DNA binding site [nucleotide binding]
101510009904	domain linker motif; other site
101510009905	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
101510009906	dimerization interface [polypeptide binding]; other site
101510009907	ligand binding site [chemical binding]; other site
101510009908	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
101510009909	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
101510009910	Walker A/P-loop; other site
101510009911	ATP binding site [chemical binding]; other site
101510009912	Q-loop/lid; other site
101510009913	ABC transporter signature motif; other site
101510009914	Walker B; other site
101510009915	D-loop; other site
101510009916	H-loop/switch region; other site
101510009917	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
101510009918	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
101510009919	TM-ABC transporter signature motif; other site
101510009920	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
101510009921	TM-ABC transporter signature motif; other site
101510009922	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
101510009923	ligand binding site [chemical binding]; other site
101510009924	Domain of unknown function (DUF718); Region: DUF718; cl01281
101510009925	L-rhamnose isomerase (RhaA); Region: RhaA; cl09945
101510009926	L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629
101510009927	L-arabinose isomerase [Carbohydrate transport and metabolism]; Region: AraA; COG2160
101510009928	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578
101510009929	hexamer (dimer of trimers) interface [polypeptide binding]; other site
101510009930	trimer interface [polypeptide binding]; other site
101510009931	substrate binding site [chemical binding]; other site
101510009932	Mn binding site [ion binding]; other site
101510009933	short chain dehydrogenase; Validated; Region: PRK08324
101510009934	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
101510009935	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510009936	NAD(P) binding site [chemical binding]; other site
101510009937	active site
101510009938	L-rhamnulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
101510009939	N- and C-terminal domain interface [polypeptide binding]; other site
101510009940	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
101510009941	active site
101510009942	catalytic site [active]
101510009943	metal binding site [ion binding]; metal-binding site
101510009944	ATP binding site [chemical binding]; other site
101510009945	carbohydrate binding site [chemical binding]; other site
101510009946	enoyl-CoA hydratase; Provisional; Region: PRK05864
101510009947	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510009948	substrate binding site [chemical binding]; other site
101510009949	oxyanion hole (OAH) forming residues; other site
101510009950	trimer interface [polypeptide binding]; other site
101510009951	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
101510009952	hydrophobic ligand binding site; other site
101510009953	Cupin domain; Region: Cupin_2; cl09118
101510009954	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
101510009955	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
101510009956	substrate binding site; other site
101510009957	tetramer interface; other site
101510009958	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
101510009959	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
101510009960	NAD binding site [chemical binding]; other site
101510009961	substrate binding site [chemical binding]; other site
101510009962	homodimer interface [polypeptide binding]; other site
101510009963	active site
101510009964	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510009965	S-adenosylmethionine binding site [chemical binding]; other site
101510009966	Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219
101510009967	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
101510009968	putative trimer interface [polypeptide binding]; other site
101510009969	putative CoA binding site [chemical binding]; other site
101510009970	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
101510009971	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
101510009972	inhibitor-cofactor binding pocket; inhibition site
101510009973	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510009974	catalytic residue [active]
101510009975	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
101510009976	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510009977	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
101510009978	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
101510009979	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
101510009980	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
101510009981	non-specific DNA binding site [nucleotide binding]; other site
101510009982	salt bridge; other site
101510009983	sequence-specific DNA binding site [nucleotide binding]; other site
101510009984	Cupin domain; Region: Cupin_2; cl09118
101510009985	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
101510009986	active site
101510009987	catalytic triad [active]
101510009988	oxyanion hole [active]
101510009989	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
101510009990	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
101510009991	active site
101510009992	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
101510009993	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
101510009994	active site
101510009995	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364
101510009996	Macrocin-O-methyltransferase (TylF); Region: TylF; pfam05711
101510009997	GTPase RsgA; Reviewed; Region: PRK01889
101510009998	YjeQ/EngC.  YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs...; Region: YjeQ_engC; cd01854
101510009999	GTPase/OB domain interface [polypeptide binding]; other site
101510010000	GTPase/Zn-binding domain interface [polypeptide binding]; other site
101510010001	GTP/Mg2+ binding site [chemical binding]; other site
101510010002	G4 box; other site
101510010003	G5 box; other site
101510010004	G1 box; other site
101510010005	Switch I region; other site
101510010006	G2 box; other site
101510010007	G3 box; other site
101510010008	Switch II region; other site
101510010009	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
101510010010	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
101510010011	active site
101510010012	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
101510010013	ABC_KpsT_Wzt   The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export.  Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220
101510010014	Walker A/P-loop; other site
101510010015	ATP binding site [chemical binding]; other site
101510010016	Q-loop/lid; other site
101510010017	ABC transporter signature motif; other site
101510010018	Walker B; other site
101510010019	D-loop; other site
101510010020	H-loop/switch region; other site
101510010021	ABC-2 type transporter; Region: ABC2_membrane; cl11417
101510010022	Protein of unknown function (DUF2587); Region: DUF2587; pfam10759
101510010023	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
101510010024	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
101510010025	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
101510010026	catalytic residue [active]
101510010027	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
101510010028	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
101510010029	NAD(P) binding site [chemical binding]; other site
101510010030	Transcriptional regulators [Transcription]; Region: MarR; COG1846
101510010031	Helix-turn-helix domains; Region: HTH; cl00088
101510010032	TfoX N-terminal domain; Region: TfoX_N; cl01167
101510010033	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
101510010034	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510010035	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
101510010036	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510010037	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
101510010038	putative hydrophobic ligand binding site [chemical binding]; other site
101510010039	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
101510010040	DinB superfamily; Region: DinB_2; cl00986
101510010041	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
101510010042	dimerization interface [polypeptide binding]; other site
101510010043	putative DNA binding site [nucleotide binding]; other site
101510010044	putative Zn2+ binding site [ion binding]; other site
101510010045	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
101510010046	DinB superfamily; Region: DinB_2; cl00986
101510010047	MDMPI C-terminal domain; Region: MDMPI_C; pfam07398
101510010048	Predicted esterase [General function prediction only]; Region: COG0627
101510010049	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
101510010050	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
101510010051	putative active site [active]
101510010052	putative metal binding site [ion binding]; other site
101510010053	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
101510010054	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
101510010055	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
101510010056	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510010057	homodimer interface [polypeptide binding]; other site
101510010058	catalytic residue [active]
101510010059	Dienelactone hydrolase family; Region: DLH; pfam01738
101510010060	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
101510010061	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510010062	putative metal binding site [ion binding]; other site
101510010063	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
101510010064	dimerization interface [polypeptide binding]; other site
101510010065	putative DNA binding site [nucleotide binding]; other site
101510010066	putative Zn2+ binding site [ion binding]; other site
101510010067	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510010068	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
101510010069	Helix-turn-helix domains; Region: HTH; cl00088
101510010070	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436
101510010071	putative dimerization interface [polypeptide binding]; other site
101510010072	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
101510010073	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
101510010074	NADP binding site [chemical binding]; other site
101510010075	homodimer interface [polypeptide binding]; other site
101510010076	active site
101510010077	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
101510010078	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510010079	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510010080	putative substrate translocation pore; other site
101510010081	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510010082	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
101510010083	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
101510010084	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
101510010085	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510010086	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
101510010087	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510010088	NmrA-like family; Region: NmrA; pfam05368
101510010089	NAD(P) binding site [chemical binding]; other site
101510010090	active site
101510010091	Domain of unknown function (DUF385); Region: DUF385; cl04387
101510010092	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
101510010093	additional DNA contacts [nucleotide binding]; other site
101510010094	mismatch recognition site; other site
101510010095	active site
101510010096	zinc binding site [ion binding]; other site
101510010097	DNA intercalation site [nucleotide binding]; other site
101510010098	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
101510010099	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510010100	cofactor binding site; other site
101510010101	DNA binding site [nucleotide binding]
101510010102	substrate interaction site [chemical binding]; other site
101510010103	Protein of unknown function (DUF1089); Region: DUF1089; cl01425
101510010104	prephenate dehydrogenase; Validated; Region: PRK06545
101510010105	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510010106	putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
101510010107	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
101510010108	nucleoside/Zn binding site; other site
101510010109	dimer interface [polypeptide binding]; other site
101510010110	catalytic motif [active]
101510010111	CsbD-like; Region: CsbD; cl01888
101510010112	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510010113	classical (c) SDRs; Region: SDR_c; cd05233
101510010114	NAD(P) binding site [chemical binding]; other site
101510010115	active site
101510010116	YceI-like domain; Region: YceI; cl01001
101510010117	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
101510010118	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510010119	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
101510010120	active site
101510010121	metal binding site [ion binding]; metal-binding site
101510010122	Predicted transcriptional regulator [Transcription]; Region: COG1959
101510010123	Helix-turn-helix domains; Region: HTH; cl00088
101510010124	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510010125	Helix-turn-helix domains; Region: HTH; cl00088
101510010126	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510010127	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
101510010128	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
101510010129	FMN-binding pocket [chemical binding]; other site
101510010130	flavin binding motif; other site
101510010131	phosphate binding motif [ion binding]; other site
101510010132	beta-alpha-beta structure motif; other site
101510010133	NAD binding pocket [chemical binding]; other site
101510010134	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510010135	catalytic loop [active]
101510010136	iron binding site [ion binding]; other site
101510010137	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
101510010138	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
101510010139	iron-sulfur cluster [ion binding]; other site
101510010140	[2Fe-2S] cluster binding site [ion binding]; other site
101510010141	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
101510010142	hydrophobic ligand binding site; other site
101510010143	hypothetical protein; Provisional; Region: PRK08317
101510010144	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510010145	S-adenosylmethionine binding site [chemical binding]; other site
101510010146	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
101510010147	Helix-turn-helix domains; Region: HTH; cl00088
101510010148	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
101510010149	Protein export membrane protein; Region: SecD_SecF; cl14618
101510010150	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
101510010151	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
101510010152	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510010153	Walker A/P-loop; other site
101510010154	ATP binding site [chemical binding]; other site
101510010155	Q-loop/lid; other site
101510010156	ABC transporter signature motif; other site
101510010157	Walker B; other site
101510010158	D-loop; other site
101510010159	H-loop/switch region; other site
101510010160	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
101510010161	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
101510010162	Glucan exporter ATP-binding protein.  In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor.  This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254
101510010163	Walker A/P-loop; other site
101510010164	ATP binding site [chemical binding]; other site
101510010165	Q-loop/lid; other site
101510010166	ABC transporter signature motif; other site
101510010167	Walker B; other site
101510010168	D-loop; other site
101510010169	H-loop/switch region; other site
101510010170	Sulfatase; Region: Sulfatase; cl10460
101510010171	Queuine tRNA-ribosyltransferase; Region: TGT; cl00409
101510010172	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756
101510010173	RDD family; Region: RDD; cl00746
101510010174	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
101510010175	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
101510010176	active site
101510010177	HIGH motif; other site
101510010178	nucleotide binding site [chemical binding]; other site
101510010179	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
101510010180	active site
101510010181	KMSKS motif; other site
101510010182	Helix-turn-helix domains; Region: HTH; cl00088
101510010183	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
101510010184	folate binding site [chemical binding]; other site
101510010185	NADP+ binding site [chemical binding]; other site
101510010186	Helix-turn-helix domains; Region: HTH; cl00088
101510010187	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
101510010188	putative acyl-acceptor binding pocket; other site
101510010189	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510010190	Helix-turn-helix domains; Region: HTH; cl00088
101510010191	Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399
101510010192	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
101510010193	putative active site [active]
101510010194	putative metal binding site [ion binding]; other site
101510010195	Helix-turn-helix domain; Region: HTH_18; pfam12833
101510010196	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510010197	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
101510010198	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
101510010199	Protein of unknown function (DUF1275); Region: DUF1275; cl01453
101510010200	Predicted esterase [General function prediction only]; Region: COG0627
101510010201	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510010202	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
101510010203	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510010204	homodimer interface [polypeptide binding]; other site
101510010205	catalytic residue [active]
101510010206	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
101510010207	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
101510010208	iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957
101510010209	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
101510010210	intersubunit interface [polypeptide binding]; other site
101510010211	enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439
101510010212	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
101510010213	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510010214	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
101510010215	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
101510010216	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
101510010217	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
101510010218	Walker A motif; other site
101510010219	ATP binding site [chemical binding]; other site
101510010220	Walker B motif; other site
101510010221	arginine finger; other site
101510010222	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
101510010223	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
101510010224	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
101510010225	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
101510010226	Histidine kinase; Region: HisKA_3; pfam07730
101510010227	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510010228	ATP binding site [chemical binding]; other site
101510010229	Mg2+ binding site [ion binding]; other site
101510010230	G-X-G motif; other site
101510010231	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
101510010232	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510010233	active site
101510010234	phosphorylation site [posttranslational modification]
101510010235	intermolecular recognition site; other site
101510010236	dimerization interface [polypeptide binding]; other site
101510010237	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510010238	DNA binding residues [nucleotide binding]
101510010239	dimerization interface [polypeptide binding]; other site
101510010240	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
101510010241	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
101510010242	dimer interface [polypeptide binding]; other site
101510010243	active site
101510010244	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510010245	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
101510010246	substrate binding site [chemical binding]; other site
101510010247	oxyanion hole (OAH) forming residues; other site
101510010248	trimer interface [polypeptide binding]; other site
101510010249	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510010250	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
101510010251	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
101510010252	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
101510010253	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510010254	S-adenosylmethionine binding site [chemical binding]; other site
101510010255	FAD binding domain; Region: FAD_binding_4; pfam01565
101510010256	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
101510010257	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
101510010258	Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494
101510010259	recombination protein RecR; Reviewed; Region: recR; PRK00076
101510010260	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
101510010261	RecR protein; Region: RecR; pfam02132
101510010262	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
101510010263	putative active site [active]
101510010264	putative metal-binding site [ion binding]; other site
101510010265	tetramer interface [polypeptide binding]; other site
101510010266	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510010267	Helix-turn-helix domains; Region: HTH; cl00088
101510010268	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510010269	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
101510010270	dimerization interface [polypeptide binding]; other site
101510010271	putative DNA binding site [nucleotide binding]; other site
101510010272	putative Zn2+ binding site [ion binding]; other site
101510010273	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898
101510010274	putative hydrophobic ligand binding site [chemical binding]; other site
101510010275	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
101510010276	catalytic triad [active]
101510010277	Mur ligase middle domain; Region: Mur_ligase_M; cl15713
101510010278	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
101510010279	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
101510010280	EamA-like transporter family; Region: EamA; cl01037
101510010281	EamA-like transporter family; Region: EamA; cl01037
101510010282	Helix-turn-helix domains; Region: HTH; cl00088
101510010283	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
101510010284	Predicted membrane protein (DUF2078); Region: DUF2078; cl01373
101510010285	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
101510010286	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
101510010287	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
101510010288	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
101510010289	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
101510010290	carboxyltransferase (CT) interaction site; other site
101510010291	biotinylation site [posttranslational modification]; other site
101510010292	Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326
101510010293	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
101510010294	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
101510010295	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
101510010296	D-pathway; other site
101510010297	Putative ubiquinol binding site [chemical binding]; other site
101510010298	Low-spin heme (heme b) binding site [chemical binding]; other site
101510010299	Putative water exit pathway; other site
101510010300	Binuclear center (heme o3/CuB) [ion binding]; other site
101510010301	K-pathway; other site
101510010302	Putative proton exit pathway; other site
101510010303	2-isopropylmalate synthase; Validated; Region: PRK03739
101510010304	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
101510010305	active site
101510010306	catalytic residues [active]
101510010307	metal binding site [ion binding]; metal-binding site
101510010308	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
101510010309	Pirin-related protein [General function prediction only]; Region: COG1741
101510010310	Cupin domain; Region: Cupin_2; cl09118
101510010311	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
101510010312	Transposase; Region: DEDD_Tnp_IS110; pfam01548
101510010313	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
101510010314	Protein of unknown function (DUF732); Region: DUF732; pfam05305
101510010315	Erythronolide synthase docking; Region: Docking; pfam08990
101510010316	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
101510010317	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
101510010318	active site
101510010319	Acyl transferase domain; Region: Acyl_transf_1; cl08282
101510010320	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
101510010321	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
101510010322	putative NADP binding site [chemical binding]; other site
101510010323	active site
101510010324	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510010325	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
101510010326	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
101510010327	active site
101510010328	Acyl transferase domain; Region: Acyl_transf_1; cl08282
101510010329	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
101510010330	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
101510010331	putative NADP binding site [chemical binding]; other site
101510010332	active site
101510010333	acyl-CoA synthetase; Validated; Region: PRK06060
101510010334	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510010335	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510010336	S-adenosylmethionine binding site [chemical binding]; other site
101510010337	Helix-turn-helix domains; Region: HTH; cl00088
101510010338	Predicted transcriptional regulator [Transcription]; Region: COG2345
101510010339	Fusaric acid resistance protein-like; Region: FUSC_2; cl15844
101510010340	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
101510010341	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
101510010342	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
101510010343	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510010344	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
101510010345	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
101510010346	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
101510010347	metal binding site [ion binding]; metal-binding site
101510010348	putative dimer interface [polypeptide binding]; other site
101510010349	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
101510010350	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
101510010351	siderophore binding site; other site
101510010352	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
101510010353	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865
101510010354	putative hydrophobic ligand binding site [chemical binding]; other site
101510010355	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510010356	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
101510010357	Transposase domain (DUF772); Region: DUF772; cl12084
101510010358	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
101510010359	YCII-related domain; Region: YCII; cl00999
101510010360	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
101510010361	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
101510010362	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358
101510010363	Cation efflux family; Region: Cation_efflux; cl00316
101510010364	enoyl-CoA hydratase; Provisional; Region: PRK08272
101510010365	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510010366	substrate binding site [chemical binding]; other site
101510010367	oxyanion hole (OAH) forming residues; other site
101510010368	trimer interface [polypeptide binding]; other site
101510010369	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
101510010370	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510010371	active site
101510010372	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510010373	Helix-turn-helix domains; Region: HTH; cl00088
101510010374	enoyl-CoA hydratase; Provisional; Region: PRK08259
101510010375	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510010376	substrate binding site [chemical binding]; other site
101510010377	oxyanion hole (OAH) forming residues; other site
101510010378	trimer interface [polypeptide binding]; other site
101510010379	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
101510010380	active site
101510010381	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
101510010382	short chain dehydrogenase; Provisional; Region: PRK06197
101510010383	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510010384	NAD(P) binding site [chemical binding]; other site
101510010385	active site
101510010386	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
101510010387	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
101510010388	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
101510010389	FMN-binding pocket [chemical binding]; other site
101510010390	flavin binding motif; other site
101510010391	phosphate binding motif [ion binding]; other site
101510010392	beta-alpha-beta structure motif; other site
101510010393	NAD binding pocket [chemical binding]; other site
101510010394	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510010395	catalytic loop [active]
101510010396	iron binding site [ion binding]; other site
101510010397	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510010398	Helix-turn-helix domains; Region: HTH; cl00088
101510010399	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
101510010400	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
101510010401	Ligand binding site; other site
101510010402	Putative Catalytic site; other site
101510010403	DXD motif; other site
101510010404	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
101510010405	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510010406	NAD(P) binding site [chemical binding]; other site
101510010407	active site
101510010408	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
101510010409	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510010410	S-adenosylmethionine binding site [chemical binding]; other site
101510010411	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321
101510010412	Moco binding site; other site
101510010413	metal coordination site [ion binding]; other site
101510010414	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
101510010415	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
101510010416	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510010417	putative substrate translocation pore; other site
101510010418	Short C-terminal domain; Region: SHOCT; cl01373
101510010419	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
101510010420	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510010421	dimer interface [polypeptide binding]; other site
101510010422	conserved gate region; other site
101510010423	putative PBP binding loops; other site
101510010424	ABC-ATPase subunit interface; other site
101510010425	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510010426	dimer interface [polypeptide binding]; other site
101510010427	conserved gate region; other site
101510010428	putative PBP binding loops; other site
101510010429	ABC-ATPase subunit interface; other site
101510010430	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
101510010431	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
101510010432	active site
101510010433	catalytic site [active]
101510010434	Transcriptional regulators [Transcription]; Region: PurR; COG1609
101510010435	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
101510010436	DNA binding site [nucleotide binding]
101510010437	domain linker motif; other site
101510010438	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
101510010439	ligand binding site [chemical binding]; other site
101510010440	dimerization interface [polypeptide binding]; other site
101510010441	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
101510010442	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
101510010443	Walker A/P-loop; other site
101510010444	ATP binding site [chemical binding]; other site
101510010445	Q-loop/lid; other site
101510010446	ABC transporter signature motif; other site
101510010447	Walker B; other site
101510010448	D-loop; other site
101510010449	H-loop/switch region; other site
101510010450	TOBE domain; Region: TOBE_2; cl01440
101510010451	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
101510010452	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
101510010453	Transcription factor WhiB; Region: Whib; pfam02467
101510010454	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510010455	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510010456	active site
101510010457	ATP binding site [chemical binding]; other site
101510010458	substrate binding site [chemical binding]; other site
101510010459	activation loop (A-loop); other site
101510010460	Uncharacterized conserved protein [Function unknown]; Region: COG3391
101510010461	NHL repeat; Region: NHL; pfam01436
101510010462	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
101510010463	transcriptional regulator MalT; Provisional; Region: PRK04841
101510010464	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510010465	DNA binding residues [nucleotide binding]
101510010466	dimerization interface [polypeptide binding]; other site
101510010467	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510010468	active site
101510010469	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
101510010470	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510010471	Domain of unknown function DUF20; Region: UPF0118; cl00465
101510010472	high affinity sulphate transporter 1; Region: sulP; TIGR00815
101510010473	Permease family; Region: Xan_ur_permease; cl00967
101510010474	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
101510010475	Uncharacterized conserved protein [Function unknown]; Region: COG5361
101510010476	Protein of unknown function (DUF1254); Region: DUF1254; cl02257
101510010477	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
101510010478	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
101510010479	aspartate kinase; Reviewed; Region: PRK06635
101510010480	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
101510010481	putative nucleotide binding site [chemical binding]; other site
101510010482	putative catalytic residues [active]
101510010483	putative Mg ion binding site [ion binding]; other site
101510010484	putative aspartate binding site [chemical binding]; other site
101510010485	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
101510010486	putative allosteric regulatory site; other site
101510010487	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
101510010488	putative allosteric regulatory residue; other site
101510010489	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
101510010490	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510010491	Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774
101510010492	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
101510010493	Integrase core domain; Region: rve; cl01316
101510010494	LysE type translocator; Region: LysE; cl00565
101510010495	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
101510010496	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
101510010497	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
101510010498	active site
101510010499	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
101510010500	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
101510010501	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
101510010502	Transcriptional regulators [Transcription]; Region: FadR; COG2186
101510010503	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510010504	DNA-binding site [nucleotide binding]; DNA binding site
101510010505	FCD domain; Region: FCD; cl11656
101510010506	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
101510010507	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
101510010508	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
101510010509	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
101510010510	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
101510010511	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510010512	Helix-turn-helix domains; Region: HTH; cl00088
101510010513	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
101510010514	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510010515	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
101510010516	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510010517	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
101510010518	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
101510010519	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
101510010520	putative DNA binding site [nucleotide binding]; other site
101510010521	putative Zn2+ binding site [ion binding]; other site
101510010522	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
101510010523	metal binding site 2 [ion binding]; metal-binding site
101510010524	putative DNA binding helix; other site
101510010525	metal binding site 1 [ion binding]; metal-binding site
101510010526	dimer interface [polypeptide binding]; other site
101510010527	structural Zn2+ binding site [ion binding]; other site
101510010528	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
101510010529	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
101510010530	tetramer interface [polypeptide binding]; other site
101510010531	heme binding pocket [chemical binding]; other site
101510010532	NADPH binding site [chemical binding]; other site
101510010533	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868
101510010534	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
101510010535	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
101510010536	siderophore binding site; other site
101510010537	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
101510010538	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
101510010539	putative active site [active]
101510010540	putative metal binding site [ion binding]; other site
101510010541	GatB domain; Region: GatB_Yqey; cl11497
101510010542	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
101510010543	Transglycosylase; Region: Transgly; cl07896
101510010544	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
101510010545	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
101510010546	Transcription factor WhiB; Region: Whib; pfam02467
101510010547	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
101510010548	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
101510010549	DTAP/Switch II; other site
101510010550	Switch I; other site
101510010551	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
101510010552	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
101510010553	P loop; other site
101510010554	Nucleotide binding site [chemical binding]; other site
101510010555	DTAP/Switch II; other site
101510010556	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
101510010557	homotrimer interaction site [polypeptide binding]; other site
101510010558	putative active site [active]
101510010559	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510010560	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
101510010561	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
101510010562	ligand binding site [chemical binding]; other site
101510010563	flexible hinge region; other site
101510010564	Helix-turn-helix domains; Region: HTH; cl00088
101510010565	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812
101510010566	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
101510010567	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
101510010568	minor groove reading motif; other site
101510010569	helix-hairpin-helix signature motif; other site
101510010570	substrate binding pocket [chemical binding]; other site
101510010571	active site
101510010572	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
101510010573	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
101510010574	catalytic residues [active]
101510010575	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
101510010576	putative active site [active]
101510010577	putative CoA binding site [chemical binding]; other site
101510010578	nudix motif; other site
101510010579	metal binding site [ion binding]; metal-binding site
101510010580	Colicin V production protein; Region: Colicin_V; cl00567
101510010581	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
101510010582	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510010583	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510010584	Protein of unknown function (DUF1469); Region: DUF1469; cl12095
101510010585	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
101510010586	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510010587	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510010588	putative substrate translocation pore; other site
101510010589	cyclase homology domain; Region: CHD; cd07302
101510010590	nucleotidyl binding site; other site
101510010591	metal binding site [ion binding]; metal-binding site
101510010592	dimer interface [polypeptide binding]; other site
101510010593	acetyl-CoA synthetase; Provisional; Region: PRK00174
101510010594	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
101510010595	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510010596	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
101510010597	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
101510010598	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
101510010599	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510010600	dimer interface [polypeptide binding]; other site
101510010601	conserved gate region; other site
101510010602	putative PBP binding loops; other site
101510010603	ABC-ATPase subunit interface; other site
101510010604	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
101510010605	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510010606	dimer interface [polypeptide binding]; other site
101510010607	conserved gate region; other site
101510010608	putative PBP binding loops; other site
101510010609	ABC-ATPase subunit interface; other site
101510010610	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
101510010611	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
101510010612	Walker A/P-loop; other site
101510010613	ATP binding site [chemical binding]; other site
101510010614	Q-loop/lid; other site
101510010615	ABC transporter signature motif; other site
101510010616	Walker B; other site
101510010617	D-loop; other site
101510010618	H-loop/switch region; other site
101510010619	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
101510010620	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
101510010621	Walker A/P-loop; other site
101510010622	ATP binding site [chemical binding]; other site
101510010623	Q-loop/lid; other site
101510010624	ABC transporter signature motif; other site
101510010625	Walker B; other site
101510010626	D-loop; other site
101510010627	H-loop/switch region; other site
101510010628	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
101510010629	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
101510010630	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
101510010631	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
101510010632	helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819
101510010633	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
101510010634	Walker A motif; other site
101510010635	hexamer interface [polypeptide binding]; other site
101510010636	ATP binding site [chemical binding]; other site
101510010637	Walker B motif; other site
101510010638	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
101510010639	helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816
101510010640	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510010641	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510010642	putative substrate translocation pore; other site
101510010643	Helix-turn-helix domains; Region: HTH; cl00088
101510010644	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
101510010645	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
101510010646	dimerization interface [polypeptide binding]; other site
101510010647	substrate binding pocket [chemical binding]; other site
101510010648	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
101510010649	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
101510010650	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
101510010651	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
101510010652	ATP binding site [chemical binding]; other site
101510010653	putative Mg++ binding site [ion binding]; other site
101510010654	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
101510010655	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
101510010656	DNA-binding site [nucleotide binding]; DNA binding site
101510010657	RNA-binding motif; other site
101510010658	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
101510010659	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
101510010660	active site
101510010661	interdomain interaction site; other site
101510010662	putative metal-binding site [ion binding]; other site
101510010663	nucleotide binding site [chemical binding]; other site
101510010664	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
101510010665	domain I; other site
101510010666	phosphate binding site [ion binding]; other site
101510010667	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
101510010668	domain II; other site
101510010669	domain III; other site
101510010670	nucleotide binding site [chemical binding]; other site
101510010671	DNA binding groove [nucleotide binding]
101510010672	catalytic site [active]
101510010673	domain IV; other site
101510010674	DNA polymerase III subunit delta'; Validated; Region: PRK07940
101510010675	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510010676	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
101510010677	ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995
101510010678	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
101510010679	substrate binding pocket [chemical binding]; other site
101510010680	membrane-bound complex binding site; other site
101510010681	hinge residues; other site
101510010682	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510010683	dimer interface [polypeptide binding]; other site
101510010684	conserved gate region; other site
101510010685	putative PBP binding loops; other site
101510010686	ABC-ATPase subunit interface; other site
101510010687	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510010688	dimer interface [polypeptide binding]; other site
101510010689	conserved gate region; other site
101510010690	putative PBP binding loops; other site
101510010691	ABC-ATPase subunit interface; other site
101510010692	ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005
101510010693	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
101510010694	Walker A/P-loop; other site
101510010695	ATP binding site [chemical binding]; other site
101510010696	Q-loop/lid; other site
101510010697	ABC transporter signature motif; other site
101510010698	Walker B; other site
101510010699	D-loop; other site
101510010700	H-loop/switch region; other site
101510010701	Membrane transport protein; Region: Mem_trans; cl09117
101510010702	Transcriptional regulator [Transcription]; Region: LysR; COG0583
101510010703	Helix-turn-helix domains; Region: HTH; cl00088
101510010704	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
101510010705	dimerization interface [polypeptide binding]; other site
101510010706	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510010707	putative substrate translocation pore; other site
101510010708	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
101510010709	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
101510010710	Domain of unknown function (DUF336); Region: DUF336; cl01249
101510010711	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243
101510010712	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
101510010713	iron-sulfur cluster [ion binding]; other site
101510010714	[2Fe-2S] cluster binding site [ion binding]; other site
101510010715	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
101510010716	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510010717	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510010718	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
101510010719	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510010720	NAD(P) binding site [chemical binding]; other site
101510010721	catalytic residues [active]
101510010722	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
101510010723	[2Fe-2S] cluster binding site [ion binding]; other site
101510010724	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
101510010725	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
101510010726	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
101510010727	homotrimer interaction site [polypeptide binding]; other site
101510010728	putative active site [active]
101510010729	Transcriptional regulators [Transcription]; Region: FadR; COG2186
101510010730	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510010731	DNA-binding site [nucleotide binding]; DNA binding site
101510010732	FCD domain; Region: FCD; cl11656
101510010733	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510010734	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
101510010735	Zn binding site [ion binding]; other site
101510010736	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
101510010737	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510010738	L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443
101510010739	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510010740	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
101510010741	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
101510010742	putative trimer interface [polypeptide binding]; other site
101510010743	putative CoA binding site [chemical binding]; other site
101510010744	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
101510010745	putative trimer interface [polypeptide binding]; other site
101510010746	putative CoA binding site [chemical binding]; other site
101510010747	YCII-related domain; Region: YCII; cl00999
101510010748	YCII-related domain; Region: YCII; cl00999
101510010749	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
101510010750	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
101510010751	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358
101510010752	agmatine deiminase; Region: agmatine_aguA; TIGR03380
101510010753	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113
101510010754	Predicted amidohydrolase [General function prediction only]; Region: COG0388
101510010755	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
101510010756	active site
101510010757	catalytic triad [active]
101510010758	dimer interface [polypeptide binding]; other site
101510010759	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
101510010760	Helix-turn-helix domains; Region: HTH; cl00088
101510010761	Sodium:solute symporter family; Region: SSF; cl00456
101510010762	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
101510010763	mce related protein; Region: MCE; cl15431
101510010764	Aminotransferase class-V; Region: Aminotran_5; pfam00266
101510010765	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
101510010766	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
101510010767	catalytic residue [active]
101510010768	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
101510010769	Flavin Reductases; Region: FlaRed; cl00801
101510010770	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
101510010771	putative deacylase active site [active]
101510010772	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
101510010773	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510010774	Helix-turn-helix domains; Region: HTH; cl00088
101510010775	poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836
101510010776	enoyl-CoA hydratase; Provisional; Region: PRK06142
101510010777	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510010778	substrate binding site [chemical binding]; other site
101510010779	oxyanion hole (OAH) forming residues; other site
101510010780	trimer interface [polypeptide binding]; other site
101510010781	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510010782	putative substrate translocation pore; other site
101510010783	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510010784	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
101510010785	dimer interface [polypeptide binding]; other site
101510010786	substrate binding site [chemical binding]; other site
101510010787	metal binding sites [ion binding]; metal-binding site
101510010788	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
101510010789	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297
101510010790	Uncharacterised conserved protein (DUF2342); Region: DUF2342; cl02183
101510010791	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
101510010792	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
101510010793	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
101510010794	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510010795	active site
101510010796	ATP binding site [chemical binding]; other site
101510010797	substrate binding site [chemical binding]; other site
101510010798	activation loop (A-loop); other site
101510010799	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
101510010800	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
101510010801	FtsH Extracellular; Region: FtsH_ext; pfam06480
101510010802	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
101510010803	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
101510010804	Walker A motif; other site
101510010805	ATP binding site [chemical binding]; other site
101510010806	Walker B motif; other site
101510010807	arginine finger; other site
101510010808	Peptidase family M41; Region: Peptidase_M41; pfam01434
101510010809	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
101510010810	homodecamer interface [polypeptide binding]; other site
101510010811	GTP cyclohydrolase I; Provisional; Region: PLN03044
101510010812	active site
101510010813	putative catalytic site residues [active]
101510010814	zinc binding site [ion binding]; other site
101510010815	GTP-CH-I/GFRP interaction surface; other site
101510010816	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
101510010817	dihydropteroate synthase; Region: DHPS; TIGR01496
101510010818	substrate binding pocket [chemical binding]; other site
101510010819	dimer interface [polypeptide binding]; other site
101510010820	inhibitor binding site; inhibition site
101510010821	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
101510010822	homooctamer interface [polypeptide binding]; other site
101510010823	active site
101510010824	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
101510010825	catalytic center binding site [active]
101510010826	ATP binding site [chemical binding]; other site
101510010827	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
101510010828	Uncharacterized conserved protein [Function unknown]; Region: COG5495
101510010829	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510010830	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
101510010831	pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380
101510010832	Pantoate-beta-alanine ligase; Region: PanC; cd00560
101510010833	active site
101510010834	ATP-binding site [chemical binding]; other site
101510010835	pantoate-binding site; other site
101510010836	HXXH motif; other site
101510010837	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
101510010838	tetramerization interface [polypeptide binding]; other site
101510010839	active site
101510010840	Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130
101510010841	Cupin domain; Region: Cupin_2; cl09118
101510010842	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
101510010843	active site residue [active]
101510010844	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
101510010845	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
101510010846	dimer interface [polypeptide binding]; other site
101510010847	putative anticodon binding site; other site
101510010848	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
101510010849	motif 1; other site
101510010850	dimer interface [polypeptide binding]; other site
101510010851	active site
101510010852	motif 2; other site
101510010853	motif 3; other site
101510010854	Lsr2; Region: Lsr2; pfam11774
101510010855	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510010856	Clp protease ATP binding subunit; Region: clpC; CHL00095
101510010857	Clp amino terminal domain; Region: Clp_N; pfam02861
101510010858	Clp amino terminal domain; Region: Clp_N; pfam02861
101510010859	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
101510010860	Walker A motif; other site
101510010861	ATP binding site [chemical binding]; other site
101510010862	Walker B motif; other site
101510010863	arginine finger; other site
101510010864	UvrB/uvrC motif; Region: UVR; pfam02151
101510010865	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
101510010866	Walker A motif; other site
101510010867	ATP binding site [chemical binding]; other site
101510010868	Walker B motif; other site
101510010869	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
101510010870	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
101510010871	DinB superfamily; Region: DinB_2; cl00986
101510010872	Predicted transcriptional regulator [Transcription]; Region: COG2378
101510010873	Helix-turn-helix domains; Region: HTH; cl00088
101510010874	OsmC-like protein; Region: OsmC; cl00767
101510010875	nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486
101510010876	thiocyanate hydrolase, gamma subunit; Region: thiocyan_alph; TIGR03887
101510010877	NHLP leader peptide domain; Region: TOMM_pelo; cl15464
101510010878	NHLP leader peptide domain; Region: TOMM_pelo; cl15464
101510010879	nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486
101510010880	nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486
101510010881	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
101510010882	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
101510010883	catalytic residues [active]
101510010884	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
101510010885	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
101510010886	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510010887	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
101510010888	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
101510010889	O-methyltransferase; Region: Methyltransf_2; pfam00891
101510010890	argininosuccinate lyase; Provisional; Region: PRK02186
101510010891	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
101510010892	hypothetical protein; Provisional; Region: PRK07206
101510010893	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cd00449
101510010894	homodimer interface [polypeptide binding]; other site
101510010895	substrate-cofactor binding pocket; other site
101510010896	Aminotransferase class IV; Region: Aminotran_4; pfam01063
101510010897	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510010898	catalytic residue [active]
101510010899	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510010900	Walker A/P-loop; other site
101510010901	ATP binding site [chemical binding]; other site
101510010902	Q-loop/lid; other site
101510010903	ABC transporter signature motif; other site
101510010904	Walker B; other site
101510010905	D-loop; other site
101510010906	H-loop/switch region; other site
101510010907	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510010908	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
101510010909	Walker A/P-loop; other site
101510010910	ATP binding site [chemical binding]; other site
101510010911	Q-loop/lid; other site
101510010912	ABC transporter signature motif; other site
101510010913	Walker B; other site
101510010914	D-loop; other site
101510010915	H-loop/switch region; other site
101510010916	Cupin domain; Region: Cupin_2; cl09118
101510010917	Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994
101510010918	O-methyltransferase; Region: Methyltransf_2; pfam00891
101510010919	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
101510010920	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
101510010921	minor groove reading motif; other site
101510010922	helix-hairpin-helix signature motif; other site
101510010923	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
101510010924	active site clefts [active]
101510010925	zinc binding site [ion binding]; other site
101510010926	dimer interface [polypeptide binding]; other site
101510010927	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
101510010928	active site
101510010929	homotetramer interface [polypeptide binding]; other site
101510010930	homodimer interface [polypeptide binding]; other site
101510010931	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
101510010932	Amino acid permease; Region: AA_permease; cl00524
101510010933	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
101510010934	Aspartase; Region: Aspartase; cd01357
101510010935	active sites [active]
101510010936	tetramer interface [polypeptide binding]; other site
101510010937	Transcriptional regulators [Transcription]; Region: FadR; COG2186
101510010938	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510010939	DNA-binding site [nucleotide binding]; DNA binding site
101510010940	FCD domain; Region: FCD; cl11656
101510010941	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
101510010942	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
101510010943	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
101510010944	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
101510010945	CoenzymeA binding site [chemical binding]; other site
101510010946	subunit interaction site [polypeptide binding]; other site
101510010947	PHB binding site; other site
101510010948	Predicted ATP-dependent serine protease [Posttranslational modification, protein turnover, chaperones]; Region: Sms; COG1066
101510010949	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510010950	Walker A motif; other site
101510010951	ATP binding site [chemical binding]; other site
101510010952	Walker B motif; other site
101510010953	Protein of unknown function (DUF461); Region: DUF461; cl01071
101510010954	CarD-like/TRCF domain; Region: CarD_TRCF; cl00588
101510010955	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
101510010956	substrate binding site; other site
101510010957	dimer interface; other site
101510010958	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
101510010959	homotrimer interaction site [polypeptide binding]; other site
101510010960	zinc binding site [ion binding]; other site
101510010961	CDP-binding sites; other site
101510010962	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
101510010963	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
101510010964	active site
101510010965	HIGH motif; other site
101510010966	nucleotide binding site [chemical binding]; other site
101510010967	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
101510010968	KMSKS motif; other site
101510010969	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
101510010970	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
101510010971	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
101510010972	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
101510010973	Fatty acid desaturase; Region: FA_desaturase; pfam00487
101510010974	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
101510010975	putative di-iron ligands [ion binding]; other site
101510010976	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
101510010977	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
101510010978	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
101510010979	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510010980	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
101510010981	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
101510010982	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
101510010983	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510010984	tetrameric interface [polypeptide binding]; other site
101510010985	NAD binding site [chemical binding]; other site
101510010986	catalytic residues [active]
101510010987	hypothetical protein; Provisional; Region: PRK06062
101510010988	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
101510010989	inhibitor-cofactor binding pocket; inhibition site
101510010990	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510010991	catalytic residue [active]
101510010992	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
101510010993	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510010994	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
101510010995	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
101510010996	LamB/YcsF family; Region: LamB_YcsF; cl00664
101510010997	EspG family; Region: ESX-1_EspG; pfam14011
101510010998	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
101510010999	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
101510011000	dimer interface [polypeptide binding]; other site
101510011001	putative PBP binding regions; other site
101510011002	ABC-ATPase subunit  interface; other site
101510011003	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
101510011004	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510011005	Walker A/P-loop; other site
101510011006	ATP binding site [chemical binding]; other site
101510011007	Q-loop/lid; other site
101510011008	ABC transporter signature motif; other site
101510011009	Walker B; other site
101510011010	D-loop; other site
101510011011	H-loop/switch region; other site
101510011012	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
101510011013	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
101510011014	intersubunit interface [polypeptide binding]; other site
101510011015	Transcriptional regulators [Transcription]; Region: PurR; COG1609
101510011016	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
101510011017	DNA binding site [nucleotide binding]
101510011018	domain linker motif; other site
101510011019	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
101510011020	putative dimerization interface [polypeptide binding]; other site
101510011021	putative ligand binding site [chemical binding]; other site
101510011022	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
101510011023	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
101510011024	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
101510011025	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
101510011026	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510011027	Helix-turn-helix domains; Region: HTH; cl00088
101510011028	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510011029	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
101510011030	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510011031	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510011032	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510011033	active site
101510011034	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510011035	active site
101510011036	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510011037	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510011038	active site
101510011039	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
101510011040	active site
101510011041	catalytic site [active]
101510011042	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
101510011043	DUF35 OB-fold domain; Region: DUF35; pfam01796
101510011044	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
101510011045	active site 2 [active]
101510011046	active site 1 [active]
101510011047	lipid-transfer protein; Provisional; Region: PRK07855
101510011048	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
101510011049	active site
101510011050	poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240
101510011051	poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839
101510011052	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
101510011053	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
101510011054	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510011055	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
101510011056	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510011057	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
101510011058	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510011059	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
101510011060	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
101510011061	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510011062	DNA binding residues [nucleotide binding]
101510011063	dimerization interface [polypeptide binding]; other site
101510011064	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510011065	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
101510011066	Walker A/P-loop; other site
101510011067	ATP binding site [chemical binding]; other site
101510011068	Q-loop/lid; other site
101510011069	ABC transporter signature motif; other site
101510011070	Walker B; other site
101510011071	D-loop; other site
101510011072	H-loop/switch region; other site
101510011073	ABC-2 type transporter; Region: ABC2_membrane; cl11417
101510011074	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510011075	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
101510011076	Ligand binding site; other site
101510011077	metal-binding site
101510011078	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206
101510011079	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510011080	Transcriptional regulator [Transcription]; Region: LysR; COG0583
101510011081	Helix-turn-helix domains; Region: HTH; cl00088
101510011082	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
101510011083	dimerization interface [polypeptide binding]; other site
101510011084	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
101510011085	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510011086	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
101510011087	nudix motif; other site
101510011088	Transposase domain (DUF772); Region: DUF772; cl12084
101510011089	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
101510011090	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
101510011091	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
101510011092	xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970
101510011093	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
101510011094	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
101510011095	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
101510011096	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
101510011097	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
101510011098	active site
101510011099	putative substrate binding pocket [chemical binding]; other site
101510011100	urate oxidase; Region: urate_oxi; TIGR03383
101510011101	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
101510011102	active site
101510011103	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
101510011104	active site
101510011105	homotetramer interface [polypeptide binding]; other site
101510011106	OHCU decarboxylase; Region: OHCU_decarbox; cl01251
101510011107	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
101510011108	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
101510011109	active site
101510011110	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510011111	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510011112	flavanone-3-hydroxylase; Provisional; Region: PLN03176
101510011113	oxidase reductase; Provisional; Region: PTZ00273
101510011114	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206
101510011115	Permease family; Region: Xan_ur_permease; cl00967
101510011116	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
101510011117	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
101510011118	non-specific DNA binding site [nucleotide binding]; other site
101510011119	salt bridge; other site
101510011120	sequence-specific DNA binding site [nucleotide binding]; other site
101510011121	Cupin domain; Region: Cupin_2; cl09118
101510011122	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
101510011123	Sodium:solute symporter family; Region: SSF; cl00456
101510011124	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510011125	DNA-binding site [nucleotide binding]; DNA binding site
101510011126	FCD domain; Region: FCD; cl11656
101510011127	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
101510011128	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
101510011129	active site
101510011130	catalytic site [active]
101510011131	tetramer interface [polypeptide binding]; other site
101510011132	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
101510011133	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
101510011134	Predicted ATPase [General function prediction only]; Region: COG1485
101510011135	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
101510011136	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
101510011137	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
101510011138	catalytic residue [active]
101510011139	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
101510011140	MoxR-like ATPases [General function prediction only]; Region: COG0714
101510011141	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
101510011142	Walker A motif; other site
101510011143	ATP binding site [chemical binding]; other site
101510011144	Walker B motif; other site
101510011145	arginine finger; other site
101510011146	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
101510011147	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
101510011148	NlpC/P60 family; Region: NLPC_P60; cl11438
101510011149	enoyl-CoA hydratase; Region: PLN02864
101510011150	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
101510011151	dimer interaction site [polypeptide binding]; other site
101510011152	substrate-binding tunnel; other site
101510011153	active site
101510011154	catalytic site [active]
101510011155	substrate binding site [chemical binding]; other site
101510011156	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843
101510011157	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510011158	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
101510011159	acetaldehyde dehydrogenase; Validated; Region: PRK08300
101510011160	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510011161	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
101510011162	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
101510011163	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
101510011164	active site
101510011165	catalytic residues [active]
101510011166	metal binding site [ion binding]; metal-binding site
101510011167	DmpG-like communication domain; Region: DmpG_comm; pfam07836
101510011168	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510011169	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
101510011170	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
101510011171	The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH).  The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531
101510011172	Naphthocyclinone hydroxylase; Region: NcnH; cd01159
101510011173	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510011174	Flavin binding site [chemical binding]; other site
101510011175	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
101510011176	homoserine O-acetyltransferase; Provisional; Region: metX; cl15472
101510011177	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
101510011178	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
101510011179	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
101510011180	active site
101510011181	Fe binding site [ion binding]; other site
101510011182	Flavin Reductases; Region: FlaRed; cl00801
101510011183	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510011184	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
101510011185	tetramerization interface [polypeptide binding]; other site
101510011186	NAD(P) binding site [chemical binding]; other site
101510011187	catalytic residues [active]
101510011188	4-aminobutyrate aminotransferase; Provisional; Region: PRK08117
101510011189	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
101510011190	inhibitor-cofactor binding pocket; inhibition site
101510011191	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510011192	catalytic residue [active]
101510011193	Domain of unknown function (DUF369); Region: DUF369; cl00950
101510011194	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
101510011195	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
101510011196	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
101510011197	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194
101510011198	putative active site [active]
101510011199	metal binding site [ion binding]; metal-binding site
101510011200	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
101510011201	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510011202	tetrameric interface [polypeptide binding]; other site
101510011203	NAD binding site [chemical binding]; other site
101510011204	catalytic residues [active]
101510011205	Transcriptional regulator [Transcription]; Region: LysR; COG0583
101510011206	Helix-turn-helix domains; Region: HTH; cl00088
101510011207	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
101510011208	dimerization interface [polypeptide binding]; other site
101510011209	Transcriptional regulators [Transcription]; Region: PurR; COG1609
101510011210	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
101510011211	DNA binding site [nucleotide binding]
101510011212	domain linker motif; other site
101510011213	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
101510011214	putative dimerization interface [polypeptide binding]; other site
101510011215	putative ligand binding site [chemical binding]; other site
101510011216	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
101510011217	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510011218	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
101510011219	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
101510011220	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
101510011221	Metal-binding active site; metal-binding site
101510011222	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
101510011223	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
101510011224	PYR/PP interface [polypeptide binding]; other site
101510011225	dimer interface [polypeptide binding]; other site
101510011226	TPP binding site [chemical binding]; other site
101510011227	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
101510011228	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
101510011229	TPP-binding site [chemical binding]; other site
101510011230	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
101510011231	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510011232	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
101510011233	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
101510011234	Aspartase; Region: Aspartase; cd01357
101510011235	active sites [active]
101510011236	tetramer interface [polypeptide binding]; other site
101510011237	histidinol dehydrogenase; Region: hisD; TIGR00069
101510011238	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
101510011239	NAD binding site [chemical binding]; other site
101510011240	dimerization interface [polypeptide binding]; other site
101510011241	product binding site; other site
101510011242	substrate binding site [chemical binding]; other site
101510011243	zinc binding site [ion binding]; other site
101510011244	catalytic residues [active]
101510011245	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
101510011246	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
101510011247	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510011248	Major Facilitator Superfamily; Region: MFS_1; pfam07690
101510011249	putative substrate translocation pore; other site
101510011250	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
101510011251	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
101510011252	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
101510011253	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
101510011254	PYR/PP interface [polypeptide binding]; other site
101510011255	dimer interface [polypeptide binding]; other site
101510011256	TPP binding site [chemical binding]; other site
101510011257	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
101510011258	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
101510011259	TPP-binding site [chemical binding]; other site
101510011260	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
101510011261	Transcriptional regulators [Transcription]; Region: PurR; COG1609
101510011262	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
101510011263	DNA binding site [nucleotide binding]
101510011264	domain linker motif; other site
101510011265	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
101510011266	putative dimerization interface [polypeptide binding]; other site
101510011267	putative ligand binding site [chemical binding]; other site
101510011268	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
101510011269	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
101510011270	Proline racemase; Region: Pro_racemase; pfam05544
101510011271	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
101510011272	Domain of unknown function (DUF1937); Region: DUF1937; pfam09152
101510011273	trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455
101510011274	Sulfatase; Region: Sulfatase; cl10460
101510011275	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
101510011276	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
101510011277	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
101510011278	Domain of unknown function DUF; Region: DUF202; cl09954
101510011279	putative amidase; Provisional; Region: PRK06169
101510011280	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
101510011281	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510011282	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
101510011283	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
101510011284	Transcriptional regulators [Transcription]; Region: GntR; COG1802
101510011285	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510011286	DNA-binding site [nucleotide binding]; DNA binding site
101510011287	FCD domain; Region: FCD; cl11656
101510011288	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184
101510011289	Helix-turn-helix domains; Region: HTH; cl00088
101510011290	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
101510011291	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510011292	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
101510011293	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
101510011294	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
101510011295	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
101510011296	short chain dehydrogenase; Provisional; Region: PRK07677
101510011297	classical (c) SDRs; Region: SDR_c; cd05233
101510011298	NAD(P) binding site [chemical binding]; other site
101510011299	active site
101510011300	Cytochrome P450; Region: p450; cl12078
101510011301	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
101510011302	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
101510011303	active site
101510011304	catalytic tetrad [active]
101510011305	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
101510011306	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
101510011307	active site
101510011308	motif I; other site
101510011309	motif II; other site
101510011310	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
101510011311	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
101510011312	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
101510011313	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
101510011314	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510011315	active site
101510011316	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
101510011317	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510011318	active site
101510011319	enoyl-CoA hydratase; Provisional; Region: PRK08290
101510011320	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510011321	substrate binding site [chemical binding]; other site
101510011322	oxyanion hole (OAH) forming residues; other site
101510011323	trimer interface [polypeptide binding]; other site
101510011324	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
101510011325	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510011326	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
101510011327	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
101510011328	FAD binding site [chemical binding]; other site
101510011329	substrate binding site [chemical binding]; other site
101510011330	catalytic base [active]
101510011331	short chain dehydrogenase; Provisional; Region: PRK07831
101510011332	classical (c) SDRs; Region: SDR_c; cd05233
101510011333	NAD(P) binding site [chemical binding]; other site
101510011334	active site
101510011335	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510011336	Helix-turn-helix domains; Region: HTH; cl00088
101510011337	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
101510011338	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
101510011339	dimer interface [polypeptide binding]; other site
101510011340	active site
101510011341	putative acetyltransferase; Provisional; Region: PRK03624
101510011342	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
101510011343	Coenzyme A binding pocket [chemical binding]; other site
101510011344	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510011345	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
101510011346	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
101510011347	G1 box; other site
101510011348	Walker A motif; other site
101510011349	ATP binding site [chemical binding]; other site
101510011350	GTP/Mg2+ binding site [chemical binding]; other site
101510011351	Walker B motif; other site
101510011352	arginine finger; other site
101510011353	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; cl00418
101510011354	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
101510011355	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510011356	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
101510011357	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419
101510011358	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
101510011359	NifU-like domain; Region: NifU; cl00484
101510011360	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
101510011361	iron-sulfur cluster [ion binding]; other site
101510011362	[2Fe-2S] cluster binding site [ion binding]; other site
101510011363	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
101510011364	Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068
101510011365	nickel binding site [ion binding]; other site
101510011366	HupF/HypC family; Region: HupF_HypC; cl00394
101510011367	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510011368	NAD(P) binding site [chemical binding]; other site
101510011369	active site
101510011370	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510011371	Helix-turn-helix domains; Region: HTH; cl00088
101510011372	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
101510011373	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
101510011374	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
101510011375	Hydrogenase formation hypA family; Region: HypD; cl12072
101510011376	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409
101510011377	HupF/HypC family; Region: HupF_HypC; cl00394
101510011378	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
101510011379	dimerization interface [polypeptide binding]; other site
101510011380	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
101510011381	ATP binding site [chemical binding]; other site
101510011382	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
101510011383	dimer interface [polypeptide binding]; other site
101510011384	active site
101510011385	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
101510011386	HupF/HypC family; Region: HupF_HypC; cl00394
101510011387	Acylphosphatase; Region: Acylphosphatase; cl00551
101510011388	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
101510011389	HypF finger; Region: zf-HYPF; pfam07503
101510011390	HypF finger; Region: zf-HYPF; pfam07503
101510011391	yrdC domain; Region: Sua5_yciO_yrdC; cl00305
101510011392	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
101510011393	oligomer interface [polypeptide binding]; other site
101510011394	active site residues [active]
101510011395	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
101510011396	salt bridge; other site
101510011397	non-specific DNA binding site [nucleotide binding]; other site
101510011398	sequence-specific DNA binding site [nucleotide binding]; other site
101510011399	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510011400	Cytochrome P450; Region: p450; cl12078
101510011401	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510011402	Helix-turn-helix domains; Region: HTH; cl00088
101510011403	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
101510011404	intersubunit interface [polypeptide binding]; other site
101510011405	active site
101510011406	Zn2+ binding site [ion binding]; other site
101510011407	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
101510011408	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510011409	Helix-turn-helix domains; Region: HTH; cl00088
101510011410	Sodium:solute symporter family; Region: SSF; cl00456
101510011411	Transcriptional regulator [Transcription]; Region: LysR; COG0583
101510011412	Helix-turn-helix domains; Region: HTH; cl00088
101510011413	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
101510011414	dimerization interface [polypeptide binding]; other site
101510011415	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510011416	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
101510011417	CoA-transferase family III; Region: CoA_transf_3; pfam02515
101510011418	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510011419	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510011420	active site
101510011421	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
101510011422	DNA-binding site [nucleotide binding]; DNA binding site
101510011423	RNA-binding motif; other site
101510011424	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510011425	Arginase family; Region: Arginase; cl00306
101510011426	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
101510011427	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
101510011428	active site
101510011429	urocanate hydratase; Provisional; Region: PRK05414
101510011430	Sodium:solute symporter family; Region: SSF; cl00456
101510011431	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
101510011432	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
101510011433	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510011434	DNA-binding site [nucleotide binding]; DNA binding site
101510011435	UTRA domain; Region: UTRA; cl01230
101510011436	Helix-turn-helix domains; Region: HTH; cl00088
101510011437	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
101510011438	Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349
101510011439	Nitronate monooxygenase; Region: NMO; pfam03060
101510011440	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
101510011441	FMN binding site [chemical binding]; other site
101510011442	substrate binding site [chemical binding]; other site
101510011443	putative catalytic residue [active]
101510011444	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
101510011445	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
101510011446	enoyl-CoA hydratase; Provisional; Region: PRK07938
101510011447	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510011448	substrate binding site [chemical binding]; other site
101510011449	oxyanion hole (OAH) forming residues; other site
101510011450	trimer interface [polypeptide binding]; other site
101510011451	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510011452	classical (c) SDRs; Region: SDR_c; cd05233
101510011453	NAD(P) binding site [chemical binding]; other site
101510011454	active site
101510011455	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510011456	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792
101510011457	NAD(P) binding site [chemical binding]; other site
101510011458	active site
101510011459	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
101510011460	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510011461	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
101510011462	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
101510011463	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510011464	S-adenosylmethionine binding site [chemical binding]; other site
101510011465	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
101510011466	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
101510011467	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
101510011468	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
101510011469	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510011470	short chain dehydrogenase; Provisional; Region: PRK07774
101510011471	classical (c) SDRs; Region: SDR_c; cd05233
101510011472	NAD(P) binding site [chemical binding]; other site
101510011473	active site
101510011474	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510011475	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
101510011476	NAD binding site [chemical binding]; other site
101510011477	catalytic residues [active]
101510011478	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510011479	classical (c) SDRs; Region: SDR_c; cd05233
101510011480	NAD(P) binding site [chemical binding]; other site
101510011481	active site
101510011482	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
101510011483	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510011484	Helix-turn-helix domains; Region: HTH; cl00088
101510011485	Cytochrome P450; Region: p450; cl12078
101510011486	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
101510011487	Helix-turn-helix domains; Region: HTH; cl00088
101510011488	Cytochrome P450; Region: p450; cl12078
101510011489	classical (c) SDRs; Region: SDR_c; cd05233
101510011490	NAD(P) binding site [chemical binding]; other site
101510011491	active site
101510011492	Cytochrome P450; Region: p450; cl12078
101510011493	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
101510011494	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
101510011495	acyl-CoA synthetase; Validated; Region: PRK07798
101510011496	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510011497	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cl00148
101510011498	primary dimer interface [polypeptide binding]; other site
101510011499	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
101510011500	Coenzyme A binding pocket [chemical binding]; other site
101510011501	Domain of unknown function (DUF385); Region: DUF385; cl04387
101510011502	acetyl-CoA acetyltransferase; Provisional; Region: PRK07850
101510011503	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
101510011504	dimer interface [polypeptide binding]; other site
101510011505	active site
101510011506	Cytochrome P450; Region: p450; cl12078
101510011507	Erythromycin esterase; Region: Erythro_esteras; pfam05139
101510011508	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510011509	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510011510	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
101510011511	acetyl-CoA acetyltransferase; Provisional; Region: PRK08313
101510011512	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
101510011513	active site
101510011514	lipid-transfer protein; Provisional; Region: PRK07937
101510011515	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
101510011516	active site
101510011517	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
101510011518	DUF35 OB-fold domain; Region: DUF35; pfam01796
101510011519	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
101510011520	DUF35 OB-fold domain; Region: DUF35; pfam01796
101510011521	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
101510011522	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
101510011523	enoyl-CoA hydratase; Provisional; Region: PRK07799
101510011524	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510011525	substrate binding site [chemical binding]; other site
101510011526	oxyanion hole (OAH) forming residues; other site
101510011527	trimer interface [polypeptide binding]; other site
101510011528	acyl-CoA synthetase; Validated; Region: PRK07798
101510011529	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510011530	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510011531	Nitronate monooxygenase; Region: NMO; pfam03060
101510011532	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
101510011533	FMN binding site [chemical binding]; other site
101510011534	substrate binding site [chemical binding]; other site
101510011535	putative catalytic residue [active]
101510011536	acyl-CoA synthetase; Validated; Region: PRK07867
101510011537	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510011538	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
101510011539	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
101510011540	active site
101510011541	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510011542	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
101510011543	FAD binding site [chemical binding]; other site
101510011544	substrate binding site [chemical binding]; other site
101510011545	catalytic base [active]
101510011546	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
101510011547	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
101510011548	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792
101510011549	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510011550	NAD(P) binding site [chemical binding]; other site
101510011551	active site
101510011552	Domain of unknown function DUF140; Region: DUF140; cl00510
101510011553	Domain of unknown function DUF140; Region: DUF140; cl00510
101510011554	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
101510011555	mce related protein; Region: MCE; cl15431
101510011556	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
101510011557	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
101510011558	mce related protein; Region: MCE; cl15431
101510011559	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
101510011560	mce related protein; Region: MCE; cl15431
101510011561	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
101510011562	mce related protein; Region: MCE; cl15431
101510011563	Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120
101510011564	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
101510011565	mce related protein; Region: MCE; cl15431
101510011566	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
101510011567	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
101510011568	mce related protein; Region: MCE; cl15431
101510011569	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510011570	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
101510011571	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510011572	NAD(P) binding site [chemical binding]; other site
101510011573	active site
101510011574	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
101510011575	Glycosyltransferase family 20; Region: Glyco_transf_20; pfam00982
101510011576	active site
101510011577	homotetramer interface [polypeptide binding]; other site
101510011578	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
101510011579	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510011580	Walker A/P-loop; other site
101510011581	ATP binding site [chemical binding]; other site
101510011582	Q-loop/lid; other site
101510011583	ABC transporter signature motif; other site
101510011584	Walker B; other site
101510011585	D-loop; other site
101510011586	H-loop/switch region; other site
101510011587	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
101510011588	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510011589	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
101510011590	Walker A/P-loop; other site
101510011591	ATP binding site [chemical binding]; other site
101510011592	Q-loop/lid; other site
101510011593	ABC transporter signature motif; other site
101510011594	Walker B; other site
101510011595	D-loop; other site
101510011596	H-loop/switch region; other site
101510011597	putative formyltransferase; Provisional; Region: PRK06988
101510011598	Formyltransferase, catalytic core domain; Region: FMT_core; cd08369
101510011599	active site
101510011600	substrate binding site [chemical binding]; other site
101510011601	cosubstrate binding site; other site
101510011602	catalytic site [active]
101510011603	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
101510011604	active site
101510011605	hexamer interface [polypeptide binding]; other site
101510011606	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510011607	homoserine O-acetyltransferase; Provisional; Region: metX; cl15472
101510011608	homoserine O-acetyltransferase; Provisional; Region: metX; cl15472
101510011609	PAS fold; Region: PAS_3; pfam08447
101510011610	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
101510011611	PAS fold; Region: PAS_4; pfam08448
101510011612	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
101510011613	metal binding site [ion binding]; metal-binding site
101510011614	active site
101510011615	I-site; other site
101510011616	peptide synthase; Provisional; Region: PRK12467
101510011617	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510011618	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510011619	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
101510011620	peptide synthase; Provisional; Region: PRK12316
101510011621	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510011622	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510011623	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
101510011624	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510011625	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510011626	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510011627	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510011628	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510011629	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510011630	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
101510011631	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
101510011632	MbtH-like protein; Region: MbtH; cl01279
101510011633	Uncharacterized conserved protein [Function unknown]; Region: COG2966
101510011634	Protein of unknown function (DUF1212); Region: DUF1212; cl01118
101510011635	Protein of unknown function (DUF1212); Region: DUF1212; cl01118
101510011636	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358
101510011637	Secretory lipase; Region: LIP; pfam03583
101510011638	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510011639	Helix-turn-helix domains; Region: HTH; cl00088
101510011640	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
101510011641	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
101510011642	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
101510011643	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
101510011644	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510011645	NmrA-like family; Region: NmrA; pfam05368
101510011646	NAD(P) binding site [chemical binding]; other site
101510011647	active site
101510011648	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122
101510011649	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
101510011650	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
101510011651	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
101510011652	DNA binding residues [nucleotide binding]
101510011653	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
101510011654	DNA binding residues [nucleotide binding]
101510011655	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
101510011656	DNA binding residues [nucleotide binding]
101510011657	putative dimer interface [polypeptide binding]; other site
101510011658	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510011659	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
101510011660	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
101510011661	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
101510011662	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510011663	active site
101510011664	phosphorylation site [posttranslational modification]
101510011665	intermolecular recognition site; other site
101510011666	dimerization interface [polypeptide binding]; other site
101510011667	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
101510011668	DNA binding site [nucleotide binding]
101510011669	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
101510011670	dimerization interface [polypeptide binding]; other site
101510011671	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
101510011672	dimer interface [polypeptide binding]; other site
101510011673	phosphorylation site [posttranslational modification]
101510011674	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510011675	ATP binding site [chemical binding]; other site
101510011676	Mg2+ binding site [ion binding]; other site
101510011677	G-X-G motif; other site
101510011678	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
101510011679	nucleotide binding site/active site [active]
101510011680	HIT family signature motif; other site
101510011681	catalytic residue [active]
101510011682	DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188
101510011683	Ligand binding site; other site
101510011684	Ligand binding site; other site
101510011685	Ligand binding site; other site
101510011686	Putative Catalytic site; other site
101510011687	DXD motif; other site
101510011688	GtrA-like protein; Region: GtrA; cl00971
101510011689	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364
101510011690	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510011691	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
101510011692	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510011693	active site
101510011694	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
101510011695	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510011696	substrate binding site [chemical binding]; other site
101510011697	oxyanion hole (OAH) forming residues; other site
101510011698	trimer interface [polypeptide binding]; other site
101510011699	DUF35 OB-fold domain; Region: DUF35; pfam01796
101510011700	lipid-transfer protein; Provisional; Region: PRK08256
101510011701	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
101510011702	active site
101510011703	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510011704	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510011705	active site
101510011706	Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173
101510011707	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
101510011708	putative active site [active]
101510011709	putative substrate binding site [chemical binding]; other site
101510011710	ATP binding site [chemical binding]; other site
101510011711	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510011712	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510011713	active site
101510011714	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
101510011715	classical (c) SDRs; Region: SDR_c; cd05233
101510011716	NAD(P) binding site [chemical binding]; other site
101510011717	active site
101510011718	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
101510011719	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510011720	NAD(P) binding site [chemical binding]; other site
101510011721	active site
101510011722	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
101510011723	D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284
101510011724	NAD binding site [chemical binding]; other site
101510011725	substrate binding site [chemical binding]; other site
101510011726	catalytic Zn binding site [ion binding]; other site
101510011727	structural Zn binding site [ion binding]; other site
101510011728	AMP-binding enzyme; Region: AMP-binding; pfam00501
101510011729	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510011730	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510011731	Helix-turn-helix domains; Region: HTH; cl00088
101510011732	EthD protein; Region: EthD; cl06234
101510011733	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510011734	Prostaglandin dehydrogenases; Region: PGDH; cd05288
101510011735	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
101510011736	NAD(P) binding site [chemical binding]; other site
101510011737	substrate binding site [chemical binding]; other site
101510011738	dimer interface [polypeptide binding]; other site
101510011739	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510011740	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510011741	NAD(P) binding site [chemical binding]; other site
101510011742	active site
101510011743	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
101510011744	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510011745	dimer interface [polypeptide binding]; other site
101510011746	conserved gate region; other site
101510011747	putative PBP binding loops; other site
101510011748	ABC-ATPase subunit interface; other site
101510011749	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
101510011750	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510011751	Walker A/P-loop; other site
101510011752	ATP binding site [chemical binding]; other site
101510011753	Q-loop/lid; other site
101510011754	ABC transporter signature motif; other site
101510011755	Walker B; other site
101510011756	D-loop; other site
101510011757	H-loop/switch region; other site
101510011758	TOBE domain; Region: TOBE_2; cl01440
101510011759	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510011760	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510011761	NAD(P) binding site [chemical binding]; other site
101510011762	active site
101510011763	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
101510011764	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510011765	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510011766	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
101510011767	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
101510011768	phosphate binding site [ion binding]; other site
101510011769	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
101510011770	TM-ABC transporter signature motif; other site
101510011771	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
101510011772	TM-ABC transporter signature motif; other site
101510011773	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
101510011774	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
101510011775	Walker A/P-loop; other site
101510011776	ATP binding site [chemical binding]; other site
101510011777	Q-loop/lid; other site
101510011778	ABC transporter signature motif; other site
101510011779	Walker B; other site
101510011780	D-loop; other site
101510011781	H-loop/switch region; other site
101510011782	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
101510011783	Walker A/P-loop; other site
101510011784	ATP binding site [chemical binding]; other site
101510011785	Q-loop/lid; other site
101510011786	ABC transporter signature motif; other site
101510011787	Walker B; other site
101510011788	D-loop; other site
101510011789	H-loop/switch region; other site
101510011790	short chain dehydrogenase; Provisional; Region: PRK07774
101510011791	classical (c) SDRs; Region: SDR_c; cd05233
101510011792	NAD(P) binding site [chemical binding]; other site
101510011793	active site
101510011794	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
101510011795	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
101510011796	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510011797	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
101510011798	dimerization interface [polypeptide binding]; other site
101510011799	putative DNA binding site [nucleotide binding]; other site
101510011800	putative Zn2+ binding site [ion binding]; other site
101510011801	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
101510011802	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
101510011803	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
101510011804	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
101510011805	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
101510011806	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510011807	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
101510011808	NAD(P) binding site [chemical binding]; other site
101510011809	active site
101510011810	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510011811	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510011812	putative substrate translocation pore; other site
101510011813	Transcriptional regulator [Transcription]; Region: LysR; COG0583
101510011814	Helix-turn-helix domains; Region: HTH; cl00088
101510011815	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
101510011816	dimerization interface [polypeptide binding]; other site
101510011817	aspartate aminotransferase; Provisional; Region: PRK05764
101510011818	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
101510011819	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510011820	homodimer interface [polypeptide binding]; other site
101510011821	catalytic residue [active]
101510011822	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
101510011823	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
101510011824	Peptidase propeptide and YPEB domain; Region: PepSY; cl15480
101510011825	Peptidase propeptide and YPEB domain; Region: PepSY; cl15480
101510011826	Protein of unknown function (DUF998); Region: DUF998; pfam06197
101510011827	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
101510011828	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
101510011829	Lyase; Region: Lyase_1; pfam00206
101510011830	tetramer interface [polypeptide binding]; other site
101510011831	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
101510011832	HIT family signature motif; other site
101510011833	catalytic residue [active]
101510011834	Protein of unknown function (DUF833); Region: DUF833; cl01315
101510011835	Helix-turn-helix domains; Region: HTH; cl00088
101510011836	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
101510011837	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510011838	Walker A/P-loop; other site
101510011839	ATP binding site [chemical binding]; other site
101510011840	Q-loop/lid; other site
101510011841	ABC transporter signature motif; other site
101510011842	Walker B; other site
101510011843	D-loop; other site
101510011844	H-loop/switch region; other site
101510011845	ABC-2 type transporter; Region: ABC2_membrane; cl11417
101510011846	2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275
101510011847	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510011848	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510011849	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510011850	NAD(P) binding site [chemical binding]; other site
101510011851	active site
101510011852	isochorismate synthase DhbC; Validated; Region: PRK06923
101510011853	chorismate binding enzyme; Region: Chorismate_bind; cl10555
101510011854	Helix-turn-helix domains; Region: HTH; cl00088
101510011855	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
101510011856	Helix-turn-helix domains; Region: HTH; cl00088
101510011857	Sodium:solute symporter family; Region: SSF; cl00456
101510011858	amidase; Provisional; Region: PRK07486
101510011859	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
101510011860	pyruvate kinase; Provisional; Region: PRK06247
101510011861	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
101510011862	active site
101510011863	domain interfaces; other site
101510011864	Glycerate kinase family; Region: Gly_kinase; cl00841
101510011865	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
101510011866	tartrate dehydrogenase; Provisional; Region: PRK08194
101510011867	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
101510011868	Helix-turn-helix domains; Region: HTH; cl00088
101510011869	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
101510011870	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
101510011871	dimerization interface [polypeptide binding]; other site
101510011872	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510011873	Major Facilitator Superfamily; Region: MFS_1; pfam07690
101510011874	putative substrate translocation pore; other site
101510011875	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510011876	TIGR03442 family protein; Region: TIGR03442
101510011877	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
101510011878	putative active site [active]
101510011879	putative dimer interface [polypeptide binding]; other site
101510011880	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088
101510011881	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
101510011882	Cupin domain; Region: Cupin_2; cl09118
101510011883	glycerate dehydrogenase; Provisional; Region: PRK06932
101510011884	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510011885	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510011886	putative substrate translocation pore; other site
101510011887	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510011888	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
101510011889	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
101510011890	conserved cys residue [active]
101510011891	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510011892	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510011893	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
101510011894	conserved cys residue [active]
101510011895	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
101510011896	ATP binding site [chemical binding]; other site
101510011897	active site
101510011898	substrate binding site [chemical binding]; other site
101510011899	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
101510011900	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510011901	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
101510011902	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
101510011903	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510011904	active site
101510011905	phosphorylation site [posttranslational modification]
101510011906	intermolecular recognition site; other site
101510011907	dimerization interface [polypeptide binding]; other site
101510011908	Helix-turn-helix domains; Region: HTH; cl00088
101510011909	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
101510011910	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510011911	ATP binding site [chemical binding]; other site
101510011912	Mg2+ binding site [ion binding]; other site
101510011913	G-X-G motif; other site
101510011914	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
101510011915	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
101510011916	catalytic residues [active]
101510011917	dimer interface [polypeptide binding]; other site
101510011918	Predicted deacetylase [General function prediction only]; Region: COG3233
101510011919	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
101510011920	putative active site [active]
101510011921	putative Zn binding site [ion binding]; other site
101510011922	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510011923	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789
101510011924	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
101510011925	putative active site [active]
101510011926	catalytic triad [active]
101510011927	Transcription factor WhiB; Region: Whib; pfam02467
101510011928	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510011929	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
101510011930	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
101510011931	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510011932	Helix-turn-helix domains; Region: HTH; cl00088
101510011933	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
101510011934	glycosyltransferase, MGT family; Region: MGT; TIGR01426
101510011935	active site
101510011936	TDP-binding site; other site
101510011937	acceptor substrate-binding pocket; other site
101510011938	homodimer interface [polypeptide binding]; other site
101510011939	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
101510011940	active site
101510011941	metal binding site [ion binding]; metal-binding site
101510011942	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
101510011943	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
101510011944	active site
101510011945	metal binding site [ion binding]; metal-binding site
101510011946	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
101510011947	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
101510011948	dimerization interface [polypeptide binding]; other site
101510011949	ATP binding site [chemical binding]; other site
101510011950	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
101510011951	dimerization interface [polypeptide binding]; other site
101510011952	ATP binding site [chemical binding]; other site
101510011953	Predicted membrane protein (DUF2319); Region: DUF2319; cl15412
101510011954	CAAX amino terminal protease self- immunity; Region: Abi; cl00558
101510011955	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
101510011956	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510011957	S-adenosylmethionine binding site [chemical binding]; other site
101510011958	amidophosphoribosyltransferase; Provisional; Region: PRK07847
101510011959	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
101510011960	active site
101510011961	tetramer interface [polypeptide binding]; other site
101510011962	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
101510011963	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
101510011964	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
101510011965	dimerization interface [polypeptide binding]; other site
101510011966	putative ATP binding site [chemical binding]; other site
101510011967	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
101510011968	L-asparaginase II; Region: Asparaginase_II; cl01842
101510011969	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
101510011970	MOSC domain; Region: MOSC; pfam03473
101510011971	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
101510011972	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
101510011973	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
101510011974	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
101510011975	Aminotransferase class IV; Region: Aminotran_4; pfam01063
101510011976	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510011977	catalytic residue [active]
101510011978	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
101510011979	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
101510011980	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
101510011981	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
101510011982	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510011983	Walker A/P-loop; other site
101510011984	ATP binding site [chemical binding]; other site
101510011985	Q-loop/lid; other site
101510011986	ABC transporter signature motif; other site
101510011987	Walker B; other site
101510011988	D-loop; other site
101510011989	H-loop/switch region; other site
101510011990	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
101510011991	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510011992	Walker A/P-loop; other site
101510011993	ATP binding site [chemical binding]; other site
101510011994	Q-loop/lid; other site
101510011995	ABC transporter signature motif; other site
101510011996	Walker B; other site
101510011997	D-loop; other site
101510011998	H-loop/switch region; other site
101510011999	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
101510012000	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
101510012001	heme-binding site [chemical binding]; other site
101510012002	Cutinase; Region: Cutinase; cl15711
101510012003	Protein of unknown function (DUF1416); Region: DUF1416; pfam07210
101510012004	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
101510012005	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
101510012006	active site residue [active]
101510012007	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
101510012008	active site residue [active]
101510012009	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
101510012010	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
101510012011	catalytic residues [active]
101510012012	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
101510012013	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
101510012014	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
101510012015	DNA binding site [nucleotide binding]
101510012016	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
101510012017	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
101510012018	Coenzyme A binding pocket [chemical binding]; other site
101510012019	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
101510012020	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
101510012021	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
101510012022	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510012023	dimer interface [polypeptide binding]; other site
101510012024	conserved gate region; other site
101510012025	putative PBP binding loops; other site
101510012026	ABC-ATPase subunit interface; other site
101510012027	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510012028	dimer interface [polypeptide binding]; other site
101510012029	conserved gate region; other site
101510012030	putative PBP binding loops; other site
101510012031	ABC-ATPase subunit interface; other site
101510012032	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
101510012033	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
101510012034	Walker A/P-loop; other site
101510012035	ATP binding site [chemical binding]; other site
101510012036	Q-loop/lid; other site
101510012037	ABC transporter signature motif; other site
101510012038	Walker B; other site
101510012039	D-loop; other site
101510012040	H-loop/switch region; other site
101510012041	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
101510012042	PhoU domain; Region: PhoU; pfam01895
101510012043	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
101510012044	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
101510012045	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
101510012046	FMN binding site [chemical binding]; other site
101510012047	active site
101510012048	catalytic residues [active]
101510012049	substrate binding site [chemical binding]; other site
101510012050	Fatty acid desaturase; Region: FA_desaturase_2; pfam03405
101510012051	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
101510012052	homodimer interface [polypeptide binding]; other site
101510012053	putative substrate binding pocket [chemical binding]; other site
101510012054	diiron center [ion binding]; other site
101510012055	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
101510012056	Protein of unknown function (DUF419); Region: DUF419; cl15265
101510012057	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
101510012058	Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
101510012059	catalytic Zn binding site [ion binding]; other site
101510012060	NAD binding site [chemical binding]; other site
101510012061	structural Zn binding site [ion binding]; other site
101510012062	GXWXG protein; Region: GXWXG; pfam14231
101510012063	Domain of unknown function (DUF4334); Region: DUF4334; pfam14232
101510012064	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510012065	Helix-turn-helix domains; Region: HTH; cl00088
101510012066	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510012067	Helix-turn-helix domains; Region: HTH; cl00088
101510012068	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510012069	Helix-turn-helix domains; Region: HTH; cl00088
101510012070	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510012071	homoserine O-acetyltransferase; Provisional; Region: metX; cl15472
101510012072	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510012073	Helix-turn-helix domains; Region: HTH; cl00088
101510012074	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
101510012075	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
101510012076	Walker A/P-loop; other site
101510012077	ATP binding site [chemical binding]; other site
101510012078	Q-loop/lid; other site
101510012079	ABC transporter signature motif; other site
101510012080	Walker B; other site
101510012081	D-loop; other site
101510012082	H-loop/switch region; other site
101510012083	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
101510012084	TM-ABC transporter signature motif; other site
101510012085	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
101510012086	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
101510012087	Walker A/P-loop; other site
101510012088	ATP binding site [chemical binding]; other site
101510012089	Q-loop/lid; other site
101510012090	ABC transporter signature motif; other site
101510012091	Walker B; other site
101510012092	D-loop; other site
101510012093	H-loop/switch region; other site
101510012094	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
101510012095	TM-ABC transporter signature motif; other site
101510012096	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
101510012097	ligand binding site [chemical binding]; other site
101510012098	classical (c) SDRs; Region: SDR_c; cd05233
101510012099	NAD(P) binding site [chemical binding]; other site
101510012100	active site
101510012101	Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219
101510012102	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510012103	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510012104	NAD(P) binding site [chemical binding]; other site
101510012105	active site
101510012106	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
101510012107	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
101510012108	Ligand Binding Site [chemical binding]; other site
101510012109	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
101510012110	Ligand Binding Site [chemical binding]; other site
101510012111	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
101510012112	putative active site; other site
101510012113	putative metal binding residues [ion binding]; other site
101510012114	signature motif; other site
101510012115	putative triphosphate binding site [ion binding]; other site
101510012116	CHAD domain; Region: CHAD; cl10506
101510012117	PSRA_1: Pseudouridine synthase, a subgroup of the RluA family. This group is comprised of bacterial proteins assigned to the RluA family of pseudouridine synthases. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PSRA_1; cd02558
101510012118	probable active site [active]
101510012119	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
101510012120	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510012121	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
101510012122	short chain dehydrogenase; Provisional; Region: PRK06197
101510012123	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
101510012124	putative NAD(P) binding site [chemical binding]; other site
101510012125	active site
101510012126	OsmC-like protein; Region: OsmC; cl00767
101510012127	Transcriptional regulators [Transcription]; Region: MarR; COG1846
101510012128	Helix-turn-helix domains; Region: HTH; cl00088
101510012129	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
101510012130	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510012131	NAD(P) binding site [chemical binding]; other site
101510012132	active site
101510012133	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
101510012134	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
101510012135	active site
101510012136	non-prolyl cis peptide bond; other site
101510012137	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
101510012138	Citrate transporter; Region: CitMHS; pfam03600
101510012139	Lsr2; Region: Lsr2; pfam11774
101510012140	NlpC/P60 family; Region: NLPC_P60; cl11438
101510012141	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
101510012142	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510012143	active site
101510012144	metal binding site [ion binding]; metal-binding site
101510012145	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
101510012146	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510012147	putative substrate translocation pore; other site
101510012148	Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890
101510012149	hypothetical protein; Provisional; Region: PRK08204
101510012150	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
101510012151	active site
101510012152	Transcriptional regulator [Transcription]; Region: LysR; COG0583
101510012153	Helix-turn-helix domains; Region: HTH; cl00088
101510012154	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
101510012155	substrate binding pocket [chemical binding]; other site
101510012156	dimerization interface [polypeptide binding]; other site
101510012157	hypothetical protein; Provisional; Region: PRK08244
101510012158	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510012159	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510012160	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510012161	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
101510012162	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510012163	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
101510012164	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
101510012165	phosphopeptide binding site; other site
101510012166	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
101510012167	phosphopeptide binding site; other site
101510012168	ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR).  DR is a well-described phenomenon occurring in fungi and shares several similarities with processes...; Region: ABCG_EPDR; cd03213
101510012169	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
101510012170	Walker A/P-loop; other site
101510012171	ATP binding site [chemical binding]; other site
101510012172	Q-loop/lid; other site
101510012173	ABC transporter signature motif; other site
101510012174	Walker B; other site
101510012175	D-loop; other site
101510012176	H-loop/switch region; other site
101510012177	ABC-2 type transporter; Region: ABC2_membrane; cl11417
101510012178	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
101510012179	Uncharacterised protein family (UPF0014); Region: UPF0014; cl00424
101510012180	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510012181	hypothetical protein; Provisional; Region: PRK06184
101510012182	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
101510012183	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
101510012184	Clp amino terminal domain; Region: Clp_N; pfam02861
101510012185	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
101510012186	Walker A motif; other site
101510012187	ATP binding site [chemical binding]; other site
101510012188	Walker B motif; other site
101510012189	arginine finger; other site
101510012190	UvrB/uvrC motif; Region: UVR; pfam02151
101510012191	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
101510012192	Walker A motif; other site
101510012193	ATP binding site [chemical binding]; other site
101510012194	Walker B motif; other site
101510012195	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
101510012196	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510012197	Helix-turn-helix domains; Region: HTH; cl00088
101510012198	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510012199	Glycerate kinase family; Region: Gly_kinase; cl00841
101510012200	Glycerate kinase family; Region: Gly_kinase; cl00841
101510012201	glyoxylate reductase; Reviewed; Region: PRK13243
101510012202	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510012203	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
101510012204	active site
101510012205	catalytic residues [active]
101510012206	metal binding site [ion binding]; metal-binding site
101510012207	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
101510012208	CoA-transferase family III; Region: CoA_transf_3; pfam02515
101510012209	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
101510012210	GntP family permease; Region: GntP_permease; cl15264
101510012211	GntP family permease; Region: GntP_permease; cl15264
101510012212	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510012213	Helix-turn-helix domain; Region: HTH_18; pfam12833
101510012214	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
101510012215	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
101510012216	THF binding site; other site
101510012217	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
101510012218	substrate binding site [chemical binding]; other site
101510012219	THF binding site; other site
101510012220	zinc-binding site [ion binding]; other site
101510012221	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
101510012222	ABC transporter signature motif; other site
101510012223	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
101510012224	Walker B; other site
101510012225	D-loop; other site
101510012226	H-loop/switch region; other site
101510012227	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510012228	Walker A/P-loop; other site
101510012229	ATP binding site [chemical binding]; other site
101510012230	NeuB family; Region: NeuB; cl00496
101510012231	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
101510012232	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206
101510012233	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
101510012234	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184
101510012235	LysE type translocator; Region: LysE; cl00565
101510012236	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
101510012237	6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254
101510012238	putative NAD(P) binding site [chemical binding]; other site
101510012239	catalytic Zn binding site [ion binding]; other site
101510012240	structural Zn binding site [ion binding]; other site
101510012241	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
101510012242	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
101510012243	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
101510012244	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510012245	aminotransferase; Validated; Region: PRK07777
101510012246	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
101510012247	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510012248	homodimer interface [polypeptide binding]; other site
101510012249	catalytic residue [active]
101510012250	Uncharacterized conserved protein [Function unknown]; Region: COG2128
101510012251	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
101510012252	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
101510012253	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
101510012254	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358
101510012255	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
101510012256	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
101510012257	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
101510012258	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
101510012259	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
101510012260	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
101510012261	Walker A/P-loop; other site
101510012262	ATP binding site [chemical binding]; other site
101510012263	Q-loop/lid; other site
101510012264	ABC transporter signature motif; other site
101510012265	Walker B; other site
101510012266	D-loop; other site
101510012267	H-loop/switch region; other site
101510012268	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
101510012269	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510012270	dimer interface [polypeptide binding]; other site
101510012271	conserved gate region; other site
101510012272	putative PBP binding loops; other site
101510012273	ABC-ATPase subunit interface; other site
101510012274	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
101510012275	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
101510012276	active site
101510012277	non-prolyl cis peptide bond; other site
101510012278	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510012279	putative substrate translocation pore; other site
101510012280	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510012281	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
101510012282	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
101510012283	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
101510012284	Protein of unknown function (DUF3239); Region: DUF3239; pfam11580
101510012285	DNA repair helicase rad25; Region: rad25; TIGR00603
101510012286	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
101510012287	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
101510012288	nucleotide binding region [chemical binding]; other site
101510012289	ATP-binding site [chemical binding]; other site
101510012290	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
101510012291	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
101510012292	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510012293	dimer interface [polypeptide binding]; other site
101510012294	conserved gate region; other site
101510012295	putative PBP binding loops; other site
101510012296	ABC-ATPase subunit interface; other site
101510012297	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
101510012298	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510012299	Walker A/P-loop; other site
101510012300	ATP binding site [chemical binding]; other site
101510012301	Q-loop/lid; other site
101510012302	ABC transporter signature motif; other site
101510012303	Walker B; other site
101510012304	D-loop; other site
101510012305	H-loop/switch region; other site
101510012306	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
101510012307	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
101510012308	active site
101510012309	non-prolyl cis peptide bond; other site
101510012310	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
101510012311	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
101510012312	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510012313	Walker A/P-loop; other site
101510012314	ATP binding site [chemical binding]; other site
101510012315	Q-loop/lid; other site
101510012316	ABC transporter signature motif; other site
101510012317	Walker B; other site
101510012318	D-loop; other site
101510012319	H-loop/switch region; other site
101510012320	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
101510012321	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
101510012322	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510012323	Walker A/P-loop; other site
101510012324	ATP binding site [chemical binding]; other site
101510012325	Q-loop/lid; other site
101510012326	ABC transporter signature motif; other site
101510012327	Walker B; other site
101510012328	D-loop; other site
101510012329	H-loop/switch region; other site
101510012330	Transposase domain (DUF772); Region: DUF772; cl12084
101510012331	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
101510012332	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510012333	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
101510012334	WYL domain; Region: WYL; cl14852
101510012335	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
101510012336	hypothetical protein; Provisional; Region: PRK11770
101510012337	Domain of unknown function (DUF307); Region: DUF307; pfam03733
101510012338	Domain of unknown function (DUF307); Region: DUF307; pfam03733
101510012339	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
101510012340	DNA-binding site [nucleotide binding]; DNA binding site
101510012341	RNA-binding motif; other site
101510012342	Protein of unknown function (DUF2771); Region: DUF2771; pfam10969
101510012343	H+ Antiporter protein; Region: 2A0121; TIGR00900
101510012344	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
101510012345	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
101510012346	Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326
101510012347	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
101510012348	active site
101510012349	Protein of unknown function (DUF2530); Region: DUF2530; pfam10745
101510012350	Permease family; Region: Xan_ur_permease; cl00967
101510012351	Helix-turn-helix domains; Region: HTH; cl00088
101510012352	H+ Antiporter protein; Region: 2A0121; TIGR00900
101510012353	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510012354	putative substrate translocation pore; other site
101510012355	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
101510012356	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390
101510012357	carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416
101510012358	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
101510012359	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
101510012360	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
101510012361	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510012362	catalytic loop [active]
101510012363	iron binding site [ion binding]; other site
101510012364	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
101510012365	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
101510012366	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
101510012367	metal ion-dependent adhesion site (MIDAS); other site
101510012368	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
101510012369	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
101510012370	Walker A motif; other site
101510012371	ATP binding site [chemical binding]; other site
101510012372	Walker B motif; other site
101510012373	arginine finger; other site
101510012374	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
101510012375	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510012376	NAD(P) binding site [chemical binding]; other site
101510012377	active site
101510012378	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
101510012379	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
101510012380	Protein of unknown function (DUF2537); Region: DUF2537; pfam10801
101510012381	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
101510012382	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510012383	DNA-binding site [nucleotide binding]; DNA binding site
101510012384	FCD domain; Region: FCD; cl11656
101510012385	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
101510012386	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
101510012387	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
101510012388	Walker A/P-loop; other site
101510012389	ATP binding site [chemical binding]; other site
101510012390	Q-loop/lid; other site
101510012391	ABC transporter signature motif; other site
101510012392	Walker B; other site
101510012393	D-loop; other site
101510012394	H-loop/switch region; other site
101510012395	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
101510012396	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
101510012397	TM-ABC transporter signature motif; other site
101510012398	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
101510012399	TM-ABC transporter signature motif; other site
101510012400	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
101510012401	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510012402	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
101510012403	nucleoside/Zn binding site; other site
101510012404	dimer interface [polypeptide binding]; other site
101510012405	catalytic motif [active]
101510012406	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
101510012407	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
101510012408	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
101510012409	catalytic residue [active]
101510012410	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
101510012411	Citrate synthase; Region: Citrate_synt; pfam00285
101510012412	oxalacetate binding site [chemical binding]; other site
101510012413	citrylCoA binding site [chemical binding]; other site
101510012414	coenzyme A binding site [chemical binding]; other site
101510012415	catalytic triad [active]
101510012416	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
101510012417	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
101510012418	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
101510012419	H+ Antiporter protein; Region: 2A0121; TIGR00900
101510012420	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510012421	putative substrate translocation pore; other site
101510012422	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
101510012423	active site
101510012424	catalytic residues [active]
101510012425	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
101510012426	dimer interface [polypeptide binding]; other site
101510012427	Citrate synthase; Region: Citrate_synt; pfam00285
101510012428	active site
101510012429	citrylCoA binding site [chemical binding]; other site
101510012430	NADH binding [chemical binding]; other site
101510012431	cationic pore residues; other site
101510012432	oxalacetate/citrate binding site [chemical binding]; other site
101510012433	coenzyme A binding site [chemical binding]; other site
101510012434	catalytic triad [active]
101510012435	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
101510012436	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
101510012437	phosphorylation site [posttranslational modification]
101510012438	dimer interface [polypeptide binding]; other site
101510012439	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510012440	ATP binding site [chemical binding]; other site
101510012441	Mg2+ binding site [ion binding]; other site
101510012442	G-X-G motif; other site
101510012443	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
101510012444	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510012445	active site
101510012446	phosphorylation site [posttranslational modification]
101510012447	intermolecular recognition site; other site
101510012448	dimerization interface [polypeptide binding]; other site
101510012449	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
101510012450	DNA binding site [nucleotide binding]
101510012451	Mechanosensitive ion channel; Region: MS_channel; pfam00924
101510012452	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
101510012453	DNA photolyase; Region: DNA_photolyase; pfam00875
101510012454	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
101510012455	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
101510012456	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510012457	Helix-turn-helix domains; Region: HTH; cl00088
101510012458	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
101510012459	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
101510012460	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510012461	Predicted esterase [General function prediction only]; Region: COG0627
101510012462	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510012463	Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719
101510012464	Domain of unknown function DUF222; Region: DUF222; pfam02720
101510012465	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
101510012466	active site
101510012467	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
101510012468	dimer interface [polypeptide binding]; other site
101510012469	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
101510012470	Ligand Binding Site [chemical binding]; other site
101510012471	Molecular Tunnel; other site
101510012472	Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777
101510012473	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780
101510012474	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780
101510012475	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780
101510012476	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
101510012477	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
101510012478	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
101510012479	xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970
101510012480	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
101510012481	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
101510012482	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
101510012483	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
101510012484	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
101510012485	hydrophobic ligand binding site; other site
101510012486	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
101510012487	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
101510012488	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
101510012489	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
101510012490	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
101510012491	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510012492	Walker A/P-loop; other site
101510012493	ATP binding site [chemical binding]; other site
101510012494	Q-loop/lid; other site
101510012495	ABC transporter signature motif; other site
101510012496	Walker B; other site
101510012497	D-loop; other site
101510012498	H-loop/switch region; other site
101510012499	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
101510012500	non-specific DNA binding site [nucleotide binding]; other site
101510012501	salt bridge; other site
101510012502	sequence-specific DNA binding site [nucleotide binding]; other site
101510012503	Ferredoxin [Energy production and conversion]; Region: COG1146
101510012504	4Fe-4S binding domain; Region: Fer4; cl02805
101510012505	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
101510012506	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510012507	Walker A/P-loop; other site
101510012508	ATP binding site [chemical binding]; other site
101510012509	Q-loop/lid; other site
101510012510	ABC transporter signature motif; other site
101510012511	Walker B; other site
101510012512	D-loop; other site
101510012513	H-loop/switch region; other site
101510012514	ABC transporter; Region: ABC_tran_2; pfam12848
101510012515	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
101510012516	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
101510012517	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510012518	S-adenosylmethionine binding site [chemical binding]; other site
101510012519	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
101510012520	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
101510012521	active site
101510012522	catalytic tetrad [active]
101510012523	Cupin superfamily (DUF985); Region: Cupin_5; cl01418
101510012524	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
101510012525	Helix-turn-helix domains; Region: HTH; cl00088
101510012526	Bacterial transcriptional activator domain; Region: BTAD; smart01043
101510012527	Predicted ATPase [General function prediction only]; Region: COG3899
101510012528	Uncharacterized conserved protein [Function unknown]; Region: COG3945
101510012529	Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140
101510012530	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
101510012531	putative active site [active]
101510012532	putative active site [active]
101510012533	catalytic site [active]
101510012534	catalytic site [active]
101510012535	Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143
101510012536	phospholipase D alpha; Region: PLN02270
101510012537	putative active site [active]
101510012538	catalytic site [active]
101510012539	Secretory lipase; Region: LIP; pfam03583
101510012540	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
101510012541	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510012542	enoyl-CoA hydratase; Provisional; Region: PRK07854
101510012543	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510012544	substrate binding site [chemical binding]; other site
101510012545	oxyanion hole (OAH) forming residues; other site
101510012546	trimer interface [polypeptide binding]; other site
101510012547	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510012548	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
101510012549	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
101510012550	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
101510012551	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
101510012552	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
101510012553	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
101510012554	Secretory lipase; Region: LIP; pfam03583
101510012555	Protein of unknown function (DUF419); Region: DUF419; cl15265
101510012556	Histidine kinase; Region: His_kinase; pfam06580
101510012557	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510012558	ATP binding site [chemical binding]; other site
101510012559	Mg2+ binding site [ion binding]; other site
101510012560	G-X-G motif; other site
101510012561	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
101510012562	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510012563	active site
101510012564	phosphorylation site [posttranslational modification]
101510012565	intermolecular recognition site; other site
101510012566	dimerization interface [polypeptide binding]; other site
101510012567	LytTr DNA-binding domain; Region: LytTR; cl04498
101510012568	Sodium:solute symporter family; Region: SSF; cl00456
101510012569	Sodium:solute symporter family; Region: SSF; cl00456
101510012570	Protein of unknown function, DUF485; Region: DUF485; cl01231
101510012571	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
101510012572	Sodium:solute symporter family; Region: SSF; cl00456
101510012573	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
101510012574	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
101510012575	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
101510012576	substrate binding pocket [chemical binding]; other site
101510012577	membrane-bound complex binding site; other site
101510012578	hinge residues; other site
101510012579	ATP-dependent DNA ligase; Reviewed; Region: PRK09632
101510012580	MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863
101510012581	nucleotide binding site [chemical binding]; other site
101510012582	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
101510012583	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
101510012584	active site
101510012585	DNA binding site [nucleotide binding]
101510012586	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
101510012587	DNA binding site [nucleotide binding]
101510012588	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
101510012589	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510012590	active site
101510012591	phosphorylation site [posttranslational modification]
101510012592	intermolecular recognition site; other site
101510012593	dimerization interface [polypeptide binding]; other site
101510012594	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
101510012595	DNA binding site [nucleotide binding]
101510012596	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
101510012597	dimerization interface [polypeptide binding]; other site
101510012598	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
101510012599	dimer interface [polypeptide binding]; other site
101510012600	phosphorylation site [posttranslational modification]
101510012601	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510012602	ATP binding site [chemical binding]; other site
101510012603	Mg2+ binding site [ion binding]; other site
101510012604	G-X-G motif; other site
101510012605	Domain of unknown function (DUF4173); Region: DUF4173; pfam13777
101510012606	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
101510012607	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510012608	Walker A/P-loop; other site
101510012609	ATP binding site [chemical binding]; other site
101510012610	Q-loop/lid; other site
101510012611	ABC transporter signature motif; other site
101510012612	Walker B; other site
101510012613	D-loop; other site
101510012614	H-loop/switch region; other site
101510012615	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510012616	DNA-binding site [nucleotide binding]; DNA binding site
101510012617	FCD domain; Region: FCD; cl11656
101510012618	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
101510012619	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
101510012620	CoA-transferase family III; Region: CoA_transf_3; pfam02515
101510012621	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510012622	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510012623	active site
101510012624	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510012625	active site
101510012626	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510012627	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
101510012628	NAD(P) binding site [chemical binding]; other site
101510012629	active site
101510012630	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
101510012631	active site
101510012632	catalytic site [active]
101510012633	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
101510012634	active site 2 [active]
101510012635	active site 1 [active]
101510012636	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
101510012637	hydrophobic ligand binding site; other site
101510012638	lipid-transfer protein; Provisional; Region: PRK08256
101510012639	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
101510012640	active site
101510012641	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510012642	Helix-turn-helix domains; Region: HTH; cl00088
101510012643	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510012644	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510012645	active site
101510012646	ATP binding site [chemical binding]; other site
101510012647	substrate binding site [chemical binding]; other site
101510012648	activation loop (A-loop); other site
101510012649	Natural resistance-associated macrophage protein; Region: Nramp; cl00836
101510012650	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510012651	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510012652	active site
101510012653	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812
101510012654	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
101510012655	homodimer interface [polypeptide binding]; other site
101510012656	substrate-cofactor binding pocket; other site
101510012657	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510012658	catalytic residue [active]
101510012659	OsmC-like protein; Region: OsmC; cl00767
101510012660	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
101510012661	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510012662	DNA-binding site [nucleotide binding]; DNA binding site
101510012663	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
101510012664	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510012665	homodimer interface [polypeptide binding]; other site
101510012666	catalytic residue [active]
101510012667	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
101510012668	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
101510012669	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
101510012670	dimer interface [polypeptide binding]; other site
101510012671	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
101510012672	active site
101510012673	Fe binding site [ion binding]; other site
101510012674	Helix-turn-helix domains; Region: HTH; cl00088
101510012675	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510012676	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510012677	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
101510012678	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
101510012679	trimer interface [polypeptide binding]; other site
101510012680	putative metal binding site [ion binding]; other site
101510012681	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
101510012682	CoA-transferase family III; Region: CoA_transf_3; pfam02515
101510012683	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
101510012684	active site
101510012685	catalytic residues [active]
101510012686	metal binding site [ion binding]; metal-binding site
101510012687	Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158
101510012688	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
101510012689	Permease family; Region: Xan_ur_permease; cl00967
101510012690	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
101510012691	active site clefts [active]
101510012692	zinc binding site [ion binding]; other site
101510012693	dimer interface [polypeptide binding]; other site
101510012694	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
101510012695	Major Facilitator Superfamily; Region: MFS_1; pfam07690
101510012696	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510012697	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510012698	Helix-turn-helix domains; Region: HTH; cl00088
101510012699	cyclase homology domain; Region: CHD; cd07302
101510012700	nucleotidyl binding site; other site
101510012701	metal binding site [ion binding]; metal-binding site
101510012702	dimer interface [polypeptide binding]; other site
101510012703	Dehydratase family; Region: ILVD_EDD; cl00340
101510012704	6-phosphogluconate dehydratase; Region: edd; TIGR01196
101510012705	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
101510012706	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
101510012707	active site
101510012708	catalytic tetrad [active]
101510012709	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510012710	putative substrate translocation pore; other site
101510012711	Major Facilitator Superfamily; Region: MFS_1; pfam07690
101510012712	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
101510012713	FAD binding domain; Region: FAD_binding_4; pfam01565
101510012714	diacylglycerol kinase; Reviewed; Region: PRK11914
101510012715	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
101510012716	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
101510012717	RNA binding surface [nucleotide binding]; other site
101510012718	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510012719	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
101510012720	putative substrate translocation pore; other site
101510012721	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
101510012722	Coenzyme A binding pocket [chemical binding]; other site
101510012723	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510012724	Major Facilitator Superfamily; Region: MFS_1; pfam07690
101510012725	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510012726	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
101510012727	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510012728	S-adenosylmethionine binding site [chemical binding]; other site
101510012729	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
101510012730	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510012731	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
101510012732	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510012733	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
101510012734	FAD binding site [chemical binding]; other site
101510012735	homotetramer interface [polypeptide binding]; other site
101510012736	substrate binding pocket [chemical binding]; other site
101510012737	catalytic base [active]
101510012738	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
101510012739	Helix-turn-helix domains; Region: HTH; cl00088
101510012740	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
101510012741	peptide synthase; Provisional; Region: PRK12467
101510012742	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510012743	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510012744	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510012745	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510012746	peptide synthase; Provisional; Region: PRK12316
101510012747	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510012748	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510012749	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510012750	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
101510012751	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510012752	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510012753	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510012754	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510012755	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510012756	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
101510012757	peptide synthase; Validated; Region: PRK05691
101510012758	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510012759	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510012760	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510012761	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
101510012762	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
101510012763	L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443
101510012764	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510012765	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
101510012766	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510012767	peptide synthase; Provisional; Region: PRK12467
101510012768	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510012769	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510012770	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510012771	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510012772	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
101510012773	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510012774	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510012775	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
101510012776	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510012777	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510012778	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
101510012779	active site
101510012780	catalytic site [active]
101510012781	substrate binding site [chemical binding]; other site
101510012782	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
101510012783	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
101510012784	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
101510012785	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
101510012786	active site
101510012787	DNA binding site [nucleotide binding]
101510012788	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
101510012789	DNA binding site [nucleotide binding]
101510012790	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
101510012791	nucleotide binding site [chemical binding]; other site
101510012792	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
101510012793	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
101510012794	Protein of unknown function (DUF1458); Region: DUF1458; cl01328
101510012795	Ferredoxin [Energy production and conversion]; Region: COG1146
101510012796	4Fe-4S binding domain; Region: Fer4; cl02805
101510012797	ferredoxin-NADP+ reductase; Region: PLN02852
101510012798	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
101510012799	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
101510012800	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510012801	dimer interface [polypeptide binding]; other site
101510012802	conserved gate region; other site
101510012803	putative PBP binding loops; other site
101510012804	ABC-ATPase subunit interface; other site
101510012805	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
101510012806	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510012807	dimer interface [polypeptide binding]; other site
101510012808	conserved gate region; other site
101510012809	putative PBP binding loops; other site
101510012810	ABC-ATPase subunit interface; other site
101510012811	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
101510012812	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
101510012813	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
101510012814	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
101510012815	Walker A/P-loop; other site
101510012816	ATP binding site [chemical binding]; other site
101510012817	Q-loop/lid; other site
101510012818	ABC transporter signature motif; other site
101510012819	Walker B; other site
101510012820	D-loop; other site
101510012821	H-loop/switch region; other site
101510012822	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
101510012823	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
101510012824	active site
101510012825	Zn binding site [ion binding]; other site
101510012826	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl01383
101510012827	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl01383
101510012828	active site
101510012829	Cupin domain; Region: Cupin_2; cl09118
101510012830	Pirin-related protein [General function prediction only]; Region: COG1741
101510012831	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
101510012832	putative active site [active]
101510012833	putative catalytic site [active]
101510012834	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
101510012835	active site
101510012836	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
101510012837	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510012838	NAD(P) binding site [chemical binding]; other site
101510012839	active site
101510012840	Helix-turn-helix domains; Region: HTH; cl00088
101510012841	Protein of unknown function (DUF3237); Region: DUF3237; cl07905
101510012842	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
101510012843	Helix-turn-helix domains; Region: HTH; cl00088
101510012844	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
101510012845	dimerization interface [polypeptide binding]; other site
101510012846	substrate binding pocket [chemical binding]; other site
101510012847	shikimate transporter; Provisional; Region: PRK09952
101510012848	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510012849	putative substrate translocation pore; other site
101510012850	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
101510012851	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
101510012852	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510012853	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
101510012854	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510012855	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510012856	putative substrate translocation pore; other site
101510012857	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510012858	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510012859	active site
101510012860	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
101510012861	Helix-turn-helix domains; Region: HTH; cl00088
101510012862	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
101510012863	dimerization interface [polypeptide binding]; other site
101510012864	substrate binding pocket [chemical binding]; other site
101510012865	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510012866	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510012867	putative substrate translocation pore; other site
101510012868	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510012869	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
101510012870	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
101510012871	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510012872	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510012873	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405
101510012874	active site
101510012875	Predicted esterase [General function prediction only]; Region: COG0627
101510012876	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510012877	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
101510012878	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
101510012879	substrate binding pocket [chemical binding]; other site
101510012880	membrane-bound complex binding site; other site
101510012881	hinge residues; other site
101510012882	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510012883	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510012884	active site
101510012885	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359
101510012886	putative dimer interface [polypeptide binding]; other site
101510012887	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510012888	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510012889	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
101510012890	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
101510012891	active site
101510012892	catalytic tetrad [active]
101510012893	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
101510012894	DNA binding residues [nucleotide binding]
101510012895	putative dimer interface [polypeptide binding]; other site
101510012896	Sodium:solute symporter family; Region: SSF; cl00456
101510012897	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
101510012898	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
101510012899	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
101510012900	nucleoside/Zn binding site; other site
101510012901	dimer interface [polypeptide binding]; other site
101510012902	catalytic motif [active]
101510012903	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
101510012904	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206
101510012905	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
101510012906	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510012907	Walker A/P-loop; other site
101510012908	ATP binding site [chemical binding]; other site
101510012909	Q-loop/lid; other site
101510012910	ABC transporter signature motif; other site
101510012911	Walker B; other site
101510012912	D-loop; other site
101510012913	H-loop/switch region; other site
101510012914	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
101510012915	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
101510012916	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
101510012917	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
101510012918	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
101510012919	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
101510012920	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
101510012921	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510012922	putative substrate translocation pore; other site
101510012923	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
101510012924	Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
101510012925	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
101510012926	Helix-turn-helix domains; Region: HTH; cl00088
101510012927	Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219
101510012928	YceI-like domain; Region: YceI; cl01001
101510012929	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510012930	Helix-turn-helix domains; Region: HTH; cl00088
101510012931	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510012932	2-isopropylmalate synthase; Validated; Region: PRK03739
101510012933	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
101510012934	active site
101510012935	catalytic residues [active]
101510012936	metal binding site [ion binding]; metal-binding site
101510012937	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
101510012938	Transcriptional regulators [Transcription]; Region: FadR; COG2186
101510012939	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510012940	DNA-binding site [nucleotide binding]; DNA binding site
101510012941	Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219
101510012942	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
101510012943	dimerization interface [polypeptide binding]; other site
101510012944	cyclase homology domain; Region: CHD; cd07302
101510012945	nucleotidyl binding site; other site
101510012946	metal binding site [ion binding]; metal-binding site
101510012947	dimer interface [polypeptide binding]; other site
101510012948	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
101510012949	Domain of unknown function DUF20; Region: UPF0118; cl00465
101510012950	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
101510012951	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
101510012952	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510012953	active site
101510012954	phosphorylation site [posttranslational modification]
101510012955	intermolecular recognition site; other site
101510012956	dimerization interface [polypeptide binding]; other site
101510012957	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510012958	DNA binding residues [nucleotide binding]
101510012959	dimerization interface [polypeptide binding]; other site
101510012960	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
101510012961	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
101510012962	LabA_like proteins; Region: LabA_like; cd06167
101510012963	putative metal binding site [ion binding]; other site
101510012964	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510012965	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
101510012966	Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821
101510012967	active site
101510012968	substrate-binding site [chemical binding]; other site
101510012969	metal-binding site [ion binding]
101510012970	GTP binding site [chemical binding]; other site
101510012971	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
101510012972	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510012973	NAD binding site [chemical binding]; other site
101510012974	catalytic residues [active]
101510012975	Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173
101510012976	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
101510012977	putative active site [active]
101510012978	putative substrate binding site [chemical binding]; other site
101510012979	ATP binding site [chemical binding]; other site
101510012980	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
101510012981	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510012982	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
101510012983	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
101510012984	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
101510012985	OpgC protein; Region: OpgC_C; cl00792
101510012986	Acyltransferase family; Region: Acyl_transf_3; pfam01757
101510012987	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
101510012988	Protein of unknown function (DUF2613); Region: DUF2613; pfam11021
101510012989	chorismate binding enzyme; Region: Chorismate_bind; cl10555
101510012990	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
101510012991	Ligand Binding Site [chemical binding]; other site
101510012992	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
101510012993	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510012994	Helix-turn-helix domains; Region: HTH; cl00088
101510012995	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
101510012996	active site 2 [active]
101510012997	active site 1 [active]
101510012998	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
101510012999	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510013000	NAD(P) binding site [chemical binding]; other site
101510013001	active site
101510013002	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
101510013003	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
101510013004	dimer interface [polypeptide binding]; other site
101510013005	active site
101510013006	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
101510013007	VanW like protein; Region: VanW; pfam04294
101510013008	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
101510013009	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
101510013010	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
101510013011	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
101510013012	FAD binding site [chemical binding]; other site
101510013013	substrate binding site [chemical binding]; other site
101510013014	catalytic residues [active]
101510013015	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
101510013016	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510013017	S-adenosylmethionine binding site [chemical binding]; other site
101510013018	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
101510013019	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
101510013020	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
101510013021	dimer interface [polypeptide binding]; other site
101510013022	active site
101510013023	CoA binding pocket [chemical binding]; other site
101510013024	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
101510013025	Domain of unknown function (DUF1994); Region: DUF1994; cl09179
101510013026	Sulfatase; Region: Sulfatase; cl10460
101510013027	3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141
101510013028	Cytochrome P450; Region: p450; cl12078
101510013029	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510013030	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
101510013031	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
101510013032	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510013033	L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases.  It is thought...; Region: LMO_FMN; cd03332
101510013034	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
101510013035	putative active site [active]
101510013036	putative substrate binding site [chemical binding]; other site
101510013037	putative FMN binding site [chemical binding]; other site
101510013038	putative catalytic residues [active]
101510013039	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
101510013040	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510013041	DNA binding residues [nucleotide binding]
101510013042	Domain of unknown function (DUF1994); Region: DUF1994; cl09179
101510013043	Excalibur calcium-binding domain; Region: Excalibur; cl05460
101510013044	Predicted esterase [General function prediction only]; Region: COG0627
101510013045	RF-1 domain; Region: RF-1; cl02875
101510013046	Probable transposase; Region: OrfB_IS605; pfam01385
101510013047	Probable transposase; Region: OrfB_IS605; pfam01385
101510013048	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
101510013049	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
101510013050	RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648
101510013051	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
101510013052	active site
101510013053	metal binding site [ion binding]; metal-binding site
101510013054	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
101510013055	putative hydrophobic ligand binding site [chemical binding]; other site
101510013056	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
101510013057	dimerization interface [polypeptide binding]; other site
101510013058	putative DNA binding site [nucleotide binding]; other site
101510013059	putative Zn2+ binding site [ion binding]; other site
101510013060	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510013061	Helix-turn-helix domains; Region: HTH; cl00088
101510013062	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
101510013063	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510013064	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
101510013065	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
101510013066	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
101510013067	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
101510013068	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390
101510013069	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
101510013070	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
101510013071	catalytic loop [active]
101510013072	iron binding site [ion binding]; other site
101510013073	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
101510013074	carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416
101510013075	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
101510013076	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
101510013077	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
101510013078	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
101510013079	MoxR-like ATPases [General function prediction only]; Region: COG0714
101510013080	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510013081	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823
101510013082	putative hydrophobic ligand binding site [chemical binding]; other site
101510013083	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
101510013084	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
101510013085	metal ion-dependent adhesion site (MIDAS); other site
101510013086	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
101510013087	nucleotide binding site [chemical binding]; other site
101510013088	Protein ECB2; Provisional; Region: PLN03077
101510013089	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
101510013090	putative active site [active]
101510013091	heme pocket [chemical binding]; other site
101510013092	Fibronectin-binding protein (FBP); Region: FBP; pfam07299
101510013093	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
101510013094	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
101510013095	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
101510013096	Transcriptional regulators [Transcription]; Region: GntR; COG1802
101510013097	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510013098	DNA-binding site [nucleotide binding]; DNA binding site
101510013099	FCD domain; Region: FCD; cl11656
101510013100	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
101510013101	NAD(P) binding site [chemical binding]; other site
101510013102	catalytic residues [active]
101510013103	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
101510013104	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510013105	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510013106	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
101510013107	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
101510013108	active site
101510013109	Transcriptional regulators [Transcription]; Region: PurR; COG1609
101510013110	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
101510013111	DNA binding site [nucleotide binding]
101510013112	domain linker motif; other site
101510013113	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
101510013114	ligand binding site [chemical binding]; other site
101510013115	dimerization interface [polypeptide binding]; other site
101510013116	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510013117	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
101510013118	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
101510013119	Transcriptional regulator [Transcription]; Region: LysR; COG0583
101510013120	Helix-turn-helix domains; Region: HTH; cl00088
101510013121	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
101510013122	putative dimerization interface [polypeptide binding]; other site
101510013123	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
101510013124	Protein of unknown function (DUF1393); Region: DUF1393; cl01942
101510013125	acyl-CoA synthetase; Validated; Region: PRK06178
101510013126	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510013127	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
101510013128	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
101510013129	dimer interface [polypeptide binding]; other site
101510013130	active site
101510013131	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
101510013132	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
101510013133	Walker A/P-loop; other site
101510013134	ATP binding site [chemical binding]; other site
101510013135	Q-loop/lid; other site
101510013136	ABC transporter signature motif; other site
101510013137	Walker B; other site
101510013138	D-loop; other site
101510013139	H-loop/switch region; other site
101510013140	Cobalt transport protein; Region: CbiQ; cl00463
101510013141	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
101510013142	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510013143	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
101510013144	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
101510013145	Citrate transporter; Region: CitMHS; pfam03600
101510013146	Transcriptional regulator [Transcription]; Region: LysR; COG0583
101510013147	Helix-turn-helix domains; Region: HTH; cl00088
101510013148	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
101510013149	putative dimerization interface [polypeptide binding]; other site
101510013150	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510013151	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
101510013152	Transcriptional regulators [Transcription]; Region: PurR; COG1609
101510013153	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
101510013154	DNA binding site [nucleotide binding]
101510013155	domain linker motif; other site
101510013156	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
101510013157	ligand binding site [chemical binding]; other site
101510013158	dimerization interface [polypeptide binding]; other site
101510013159	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
101510013160	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510013161	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
101510013162	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
101510013163	Helix-turn-helix domains; Region: HTH; cl00088
101510013164	Winged helix-turn helix; Region: HTH_29; pfam13551
101510013165	Helix-turn-helix domains; Region: HTH; cl00088
101510013166	Integrase core domain; Region: rve; cl01316
101510013167	Histidine kinase; Region: HisKA_3; pfam07730
101510013168	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
101510013169	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
101510013170	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510013171	active site
101510013172	phosphorylation site [posttranslational modification]
101510013173	intermolecular recognition site; other site
101510013174	dimerization interface [polypeptide binding]; other site
101510013175	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510013176	DNA binding residues [nucleotide binding]
101510013177	dimerization interface [polypeptide binding]; other site
101510013178	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
101510013179	metal binding site 2 [ion binding]; metal-binding site
101510013180	putative DNA binding helix; other site
101510013181	metal binding site 1 [ion binding]; metal-binding site
101510013182	dimer interface [polypeptide binding]; other site
101510013183	structural Zn2+ binding site [ion binding]; other site
101510013184	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
101510013185	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
101510013186	dimer interface [polypeptide binding]; other site
101510013187	active site
101510013188	heme binding site [chemical binding]; other site
101510013189	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
101510013190	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
101510013191	acetoin reductases; Region: 23BDH; TIGR02415
101510013192	NAD binding site [chemical binding]; other site
101510013193	homotetramer interface [polypeptide binding]; other site
101510013194	homodimer interface [polypeptide binding]; other site
101510013195	active site
101510013196	substrate binding site [chemical binding]; other site
101510013197	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
101510013198	Helix-turn-helix domains; Region: HTH; cl00088
101510013199	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
101510013200	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
101510013201	inhibitor site; inhibition site
101510013202	active site
101510013203	dimer interface [polypeptide binding]; other site
101510013204	catalytic residue [active]
101510013205	Amino acid permease; Region: AA_permease; cl00524
101510013206	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
101510013207	Proline racemase; Region: Pro_racemase; pfam05544
101510013208	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
101510013209	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510013210	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
101510013211	NAD(P) binding site [chemical binding]; other site
101510013212	catalytic residues [active]
101510013213	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510013214	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
101510013215	tetrameric interface [polypeptide binding]; other site
101510013216	NAD binding site [chemical binding]; other site
101510013217	catalytic residues [active]
101510013218	substrate binding site [chemical binding]; other site
101510013219	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510013220	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
101510013221	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
101510013222	Transcriptional regulators [Transcription]; Region: FadR; COG2186
101510013223	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510013224	DNA-binding site [nucleotide binding]; DNA binding site
101510013225	FCD domain; Region: FCD; cl11656
101510013226	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510013227	classical (c) SDRs; Region: SDR_c; cd05233
101510013228	NAD(P) binding site [chemical binding]; other site
101510013229	active site
101510013230	Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; pfam09663
101510013231	ring-opening amidohydrolases; Region: amido_AtzD_TrzD; TIGR02714
101510013232	amidase; Provisional; Region: PRK07486
101510013233	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
101510013234	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
101510013235	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510013236	Helix-turn-helix domains; Region: HTH; cl00088
101510013237	benzoate transport; Region: 2A0115; TIGR00895
101510013238	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510013239	putative substrate translocation pore; other site
101510013240	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
101510013241	active site
101510013242	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184
101510013243	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
101510013244	homotrimer interaction site [polypeptide binding]; other site
101510013245	putative active site [active]
101510013246	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
101510013247	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510013248	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
101510013249	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510013250	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
101510013251	substrate binding pocket [chemical binding]; other site
101510013252	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510013253	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
101510013254	Peptidase C26; Region: Peptidase_C26; pfam07722
101510013255	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
101510013256	catalytic triad [active]
101510013257	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510013258	Helix-turn-helix domains; Region: HTH; cl00088
101510013259	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184
101510013260	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510013261	Helix-turn-helix domains; Region: HTH; cl00088
101510013262	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
101510013263	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510013264	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
101510013265	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510013266	substrate binding site [chemical binding]; other site
101510013267	oxyanion hole (OAH) forming residues; other site
101510013268	trimer interface [polypeptide binding]; other site
101510013269	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
101510013270	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
101510013271	NAD binding site [chemical binding]; other site
101510013272	catalytic Zn binding site [ion binding]; other site
101510013273	substrate binding site [chemical binding]; other site
101510013274	structural Zn binding site [ion binding]; other site
101510013275	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510013276	NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078
101510013277	NAD(P) binding site [chemical binding]; other site
101510013278	catalytic residues [active]
101510013279	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
101510013280	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
101510013281	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
101510013282	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510013283	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
101510013284	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510013285	4-coumarate--CoA ligase; Region: PLN02246
101510013286	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510013287	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510013288	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510013289	active site
101510013290	ATP binding site [chemical binding]; other site
101510013291	substrate binding site [chemical binding]; other site
101510013292	activation loop (A-loop); other site
101510013293	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510013294	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510013295	DNA binding residues [nucleotide binding]
101510013296	dimerization interface [polypeptide binding]; other site
101510013297	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX.  The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
101510013298	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
101510013299	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510013300	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510013301	Magnetospirillum NAD(P)+-dependent aldehyde dehydrogenase MSR-1-like; Region: ALDH_MGR_2402; cd07108
101510013302	NAD(P) binding site [chemical binding]; other site
101510013303	catalytic residues [active]
101510013304	catalytic residues [active]
101510013305	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
101510013306	Amino acid permease; Region: AA_permease; cl00524
101510013307	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
101510013308	Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Region: GlyA; COG0112
101510013309	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
101510013310	catalytic residue [active]
101510013311	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
101510013312	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
101510013313	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
101510013314	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
101510013315	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
101510013316	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510013317	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
101510013318	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510013319	Helix-turn-helix domains; Region: HTH; cl00088
101510013320	2'-deoxycytidine 5'-triphosphate deaminase (DCD); Region: DCD; pfam06559
101510013321	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
101510013322	trimer interface [polypeptide binding]; other site
101510013323	active site
101510013324	Lecithin:cholesterol acyltransferase; Region: LACT; pfam02450
101510013325	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510013326	CHAT domain; Region: CHAT; cl02083
101510013327	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
101510013328	active site
101510013329	catalytic residues [active]
101510013330	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
101510013331	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
101510013332	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
101510013333	active site
101510013334	substrate binding site [chemical binding]; other site
101510013335	Mg2+ binding site [ion binding]; other site
101510013336	Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275
101510013337	active site
101510013338	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
101510013339	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
101510013340	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
101510013341	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
101510013342	Walker A/P-loop; other site
101510013343	ATP binding site [chemical binding]; other site
101510013344	Q-loop/lid; other site
101510013345	ABC transporter signature motif; other site
101510013346	Walker B; other site
101510013347	D-loop; other site
101510013348	H-loop/switch region; other site
101510013349	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
101510013350	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
101510013351	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
101510013352	Walker A/P-loop; other site
101510013353	ATP binding site [chemical binding]; other site
101510013354	Q-loop/lid; other site
101510013355	ABC transporter signature motif; other site
101510013356	Walker B; other site
101510013357	D-loop; other site
101510013358	H-loop/switch region; other site
101510013359	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
101510013360	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
101510013361	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510013362	dimer interface [polypeptide binding]; other site
101510013363	conserved gate region; other site
101510013364	putative PBP binding loops; other site
101510013365	ABC-ATPase subunit interface; other site
101510013366	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
101510013367	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510013368	putative PBP binding loops; other site
101510013369	dimer interface [polypeptide binding]; other site
101510013370	ABC-ATPase subunit interface; other site
101510013371	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
101510013372	Rdx family; Region: Rdx; cl01407
101510013373	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
101510013374	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
101510013375	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
101510013376	catalytic triad [active]
101510013377	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
101510013378	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
101510013379	DNA binding residues [nucleotide binding]
101510013380	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
101510013381	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
101510013382	RNA polymerase factor sigma-70; Validated; Region: PRK08241
101510013383	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
101510013384	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358
101510013385	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510013386	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893
101510013387	putative hydrophobic ligand binding site [chemical binding]; other site
101510013388	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
101510013389	dimerization interface [polypeptide binding]; other site
101510013390	putative DNA binding site [nucleotide binding]; other site
101510013391	putative Zn2+ binding site [ion binding]; other site
101510013392	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
101510013393	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
101510013394	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
101510013395	Major Facilitator Superfamily; Region: MFS_1; pfam07690
101510013396	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510013397	putative substrate translocation pore; other site
101510013398	Helix-turn-helix domains; Region: HTH; cl00088
101510013399	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
101510013400	dimerization interface [polypeptide binding]; other site
101510013401	putative DNA binding site [nucleotide binding]; other site
101510013402	putative Zn2+ binding site [ion binding]; other site
101510013403	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
101510013404	Cation efflux family; Region: Cation_efflux; cl00316
101510013405	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
101510013406	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
101510013407	active site residue [active]
101510013408	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
101510013409	active site residue [active]
101510013410	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
101510013411	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
101510013412	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
101510013413	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
101510013414	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
101510013415	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
101510013416	motif II; other site
101510013417	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510013418	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
101510013419	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
101510013420	active site
101510013421	TDP-binding site; other site
101510013422	acceptor substrate-binding pocket; other site
101510013423	homodimer interface [polypeptide binding]; other site
101510013424	SPW repeat; Region: SPW; pfam03779
101510013425	SPW repeat; Region: SPW; pfam03779
101510013426	Integral membrane protein TerC family; Region: TerC; cl10468
101510013427	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510013428	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
101510013429	tetrameric interface [polypeptide binding]; other site
101510013430	NAD binding site [chemical binding]; other site
101510013431	catalytic residues [active]
101510013432	substrate binding site [chemical binding]; other site
101510013433	hypothetical protein; Provisional; Region: PRK06541
101510013434	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
101510013435	inhibitor-cofactor binding pocket; inhibition site
101510013436	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510013437	catalytic residue [active]
101510013438	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
101510013439	Helix-turn-helix domains; Region: HTH; cl00088
101510013440	Amino acid permease; Region: AA_permease; cl00524
101510013441	Cupin domain; Region: Cupin_2; cl09118
101510013442	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510013443	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
101510013444	Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999
101510013445	Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616
101510013446	putative substrate binding site [chemical binding]; other site
101510013447	active site
101510013448	Domain of unknown function (DUF385); Region: DUF385; cl04387
101510013449	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614
101510013450	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
101510013451	NAD(P) binding site [chemical binding]; other site
101510013452	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
101510013453	classical (c) SDRs; Region: SDR_c; cd05233
101510013454	NAD(P) binding site [chemical binding]; other site
101510013455	active site
101510013456	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510013457	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510013458	putative substrate translocation pore; other site
101510013459	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
101510013460	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
101510013461	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
101510013462	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
101510013463	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
101510013464	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
101510013465	carboxyltransferase (CT) interaction site; other site
101510013466	biotinylation site [posttranslational modification]; other site
101510013467	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
101510013468	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780
101510013469	Flavin Reductases; Region: FlaRed; cl00801
101510013470	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510013471	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
101510013472	enoyl-CoA hydratase; Provisional; Region: PRK08272
101510013473	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510013474	substrate binding site [chemical binding]; other site
101510013475	oxyanion hole (OAH) forming residues; other site
101510013476	trimer interface [polypeptide binding]; other site
101510013477	enoyl-CoA hydratase; Provisional; Region: PRK06494
101510013478	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510013479	substrate binding site [chemical binding]; other site
101510013480	oxyanion hole (OAH) forming residues; other site
101510013481	trimer interface [polypeptide binding]; other site
101510013482	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510013483	classical (c) SDRs; Region: SDR_c; cd05233
101510013484	NAD(P) binding site [chemical binding]; other site
101510013485	active site
101510013486	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510013487	Helix-turn-helix domains; Region: HTH; cl00088
101510013488	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510013489	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
101510013490	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
101510013491	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510013492	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510013493	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
101510013494	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
101510013495	Riboflavin kinase; Region: Flavokinase; cl03312
101510013496	Helix-turn-helix domains; Region: HTH; cl00088
101510013497	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510013498	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
101510013499	binding surface
101510013500	TPR motif; other site
101510013501	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510013502	DNA binding residues [nucleotide binding]
101510013503	dimerization interface [polypeptide binding]; other site
101510013504	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510013505	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510013506	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
101510013507	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510013508	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510013509	NAD(P) binding site [chemical binding]; other site
101510013510	active site
101510013511	Major Facilitator Superfamily; Region: MFS_1; pfam07690
101510013512	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510013513	putative substrate translocation pore; other site
101510013514	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
101510013515	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
101510013516	Probable transposase; Region: OrfB_IS605; pfam01385
101510013517	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
101510013518	Predicted ATPase [General function prediction only]; Region: COG3899
101510013519	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510013520	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510013521	DNA binding residues [nucleotide binding]
101510013522	dimerization interface [polypeptide binding]; other site
101510013523	Peptidase S8 family domain, uncharacterized subfamily 12; Region: Peptidases_S8_12; cd07480
101510013524	active site
101510013525	catalytic triad [active]
101510013526	propanediol utilization protein PduB; Provisional; Region: PRK15415
101510013527	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
101510013528	Catalytic site; other site
101510013529	peptide synthase; Validated; Region: PRK05691
101510013530	peptide synthase; Provisional; Region: PRK12316
101510013531	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510013532	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510013533	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
101510013534	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510013535	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510013536	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510013537	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510013538	peptide synthase; Provisional; Region: PRK12467
101510013539	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510013540	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510013541	Predicted esterase [General function prediction only]; Region: COG0627
101510013542	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
101510013543	Bacterial sugar transferase; Region: Bac_transf; cl00939
101510013544	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
101510013545	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
101510013546	active site
101510013547	Substrate binding site; other site
101510013548	Mg++ binding site; other site
101510013549	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
101510013550	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
101510013551	Phosphomannose isomerase type I; Region: PMI_typeI; cl15429
101510013552	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
101510013553	active site
101510013554	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
101510013555	Bacterial sugar transferase; Region: Bac_transf; cl00939
101510013556	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
101510013557	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
101510013558	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
101510013559	trimer interface [polypeptide binding]; other site
101510013560	active site
101510013561	substrate binding site [chemical binding]; other site
101510013562	CoA binding site [chemical binding]; other site
101510013563	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
101510013564	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
101510013565	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
101510013566	GDP-mannose 4,6-dehydratase; Region: PLN02653
101510013567	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
101510013568	NADP-binding site; other site
101510013569	homotetramer interface [polypeptide binding]; other site
101510013570	substrate binding site [chemical binding]; other site
101510013571	homodimer interface [polypeptide binding]; other site
101510013572	active site
101510013573	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
101510013574	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
101510013575	NADP binding site [chemical binding]; other site
101510013576	active site
101510013577	putative substrate binding site [chemical binding]; other site
101510013578	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
101510013579	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510013580	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
101510013581	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510013582	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
101510013583	putative active site [active]
101510013584	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
101510013585	O-Antigen ligase; Region: Wzy_C; cl04850
101510013586	Protein of unknown function (DUF4012); Region: DUF4012; pfam13196
101510013587	peptide synthase; Provisional; Region: PRK12467
101510013588	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510013589	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510013590	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510013591	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510013592	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510013593	peptide synthase; Provisional; Region: PRK12467
101510013594	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510013595	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510013596	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510013597	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510013598	peptide synthase; Provisional; Region: PRK12467
101510013599	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510013600	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510013601	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510013602	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510013603	peptide synthase; Provisional; Region: PRK12467
101510013604	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510013605	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510013606	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510013607	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510013608	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510013609	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
101510013610	Chain length determinant protein; Region: Wzz; cl01623
101510013611	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
101510013612	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510013613	Low molecular weight phosphatase family; Region: LMWPc; cl00105
101510013614	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
101510013615	active site
101510013616	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
101510013617	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510013618	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
101510013619	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510013620	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510013621	chaperone protein HscA; Provisional; Region: hscA; PRK05183
101510013622	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
101510013623	YibE/F-like protein; Region: YibE_F; cl02259
101510013624	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
101510013625	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
101510013626	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
101510013627	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510013628	homodimer interface [polypeptide binding]; other site
101510013629	catalytic residue [active]
101510013630	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
101510013631	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
101510013632	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
101510013633	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510013634	Condensation domain; Region: Condensation; pfam00668
101510013635	peptide synthase; Provisional; Region: PRK12316
101510013636	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510013637	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510013638	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
101510013639	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510013640	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510013641	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510013642	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510013643	peptide synthase; Provisional; Region: PRK12316
101510013644	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510013645	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510013646	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510013647	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510013648	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
101510013649	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510013650	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510013651	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
101510013652	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510013653	Era (E. coli Ras-like protein)-like.  This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880
101510013654	G1 box; other site
101510013655	GTP/Mg2+ binding site [chemical binding]; other site
101510013656	G2 box; other site
101510013657	Switch II region; other site
101510013658	G3 box; other site
101510013659	G4 box; other site
101510013660	G5 box; other site
101510013661	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
101510013662	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
101510013663	4Fe-4S binding domain; Region: Fer4; cl02805
101510013664	Cysteine-rich domain; Region: CCG; pfam02754
101510013665	Cysteine-rich domain; Region: CCG; pfam02754
101510013666	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
101510013667	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
101510013668	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510013669	DNA binding residues [nucleotide binding]
101510013670	dimerization interface [polypeptide binding]; other site
101510013671	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
101510013672	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510013673	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
101510013674	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510013675	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088
101510013676	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
101510013677	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
101510013678	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
101510013679	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
101510013680	dimer interface [polypeptide binding]; other site
101510013681	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
101510013682	active site
101510013683	Probable transposase; Region: OrfB_IS605; pfam01385
101510013684	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
101510013685	DinB superfamily; Region: DinB_2; cl00986
101510013686	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
101510013687	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
101510013688	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
101510013689	dimer interface [polypeptide binding]; other site
101510013690	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
101510013691	chaperone protein DnaJ; Provisional; Region: PRK14290
101510013692	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
101510013693	HSP70 interaction site [polypeptide binding]; other site
101510013694	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
101510013695	Zn binding sites [ion binding]; other site
101510013696	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
101510013697	dimer interface [polypeptide binding]; other site
101510013698	Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279
101510013699	DNA binding residues [nucleotide binding]
101510013700	putative dimer interface [polypeptide binding]; other site
101510013701	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
101510013702	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510013703	active site
101510013704	phosphorylation site [posttranslational modification]
101510013705	intermolecular recognition site; other site
101510013706	dimerization interface [polypeptide binding]; other site
101510013707	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510013708	DNA binding residues [nucleotide binding]
101510013709	dimerization interface [polypeptide binding]; other site
101510013710	Histidine kinase; Region: HisKA_3; pfam07730
101510013711	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510013712	ATP binding site [chemical binding]; other site
101510013713	Mg2+ binding site [ion binding]; other site
101510013714	G-X-G motif; other site
101510013715	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
101510013716	proposed catalytic triad [active]
101510013717	conserved cys residue [active]
101510013718	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510013719	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510013720	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
101510013721	iron-sulfur cluster [ion binding]; other site
101510013722	[2Fe-2S] cluster binding site [ion binding]; other site
101510013723	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
101510013724	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
101510013725	NAD binding site [chemical binding]; other site
101510013726	catalytic Zn binding site [ion binding]; other site
101510013727	structural Zn binding site [ion binding]; other site
101510013728	ChaB; Region: ChaB; cl01887
101510013729	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
101510013730	Competence-damaged protein; Region: CinA; cl00666
101510013731	acyl-CoA synthetase; Validated; Region: PRK06188
101510013732	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510013733	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
101510013734	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
101510013735	heme-binding site [chemical binding]; other site
101510013736	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
101510013737	FAD binding pocket [chemical binding]; other site
101510013738	FAD binding motif [chemical binding]; other site
101510013739	phosphate binding motif [ion binding]; other site
101510013740	beta-alpha-beta structure motif; other site
101510013741	NAD binding pocket [chemical binding]; other site
101510013742	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
101510013743	FAD binding pocket [chemical binding]; other site
101510013744	FAD binding motif [chemical binding]; other site
101510013745	phosphate binding motif [ion binding]; other site
101510013746	beta-alpha-beta structure motif; other site
101510013747	NAD binding pocket [chemical binding]; other site
101510013748	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
101510013749	heme-binding site [chemical binding]; other site
101510013750	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
101510013751	FAD binding pocket [chemical binding]; other site
101510013752	FAD binding motif [chemical binding]; other site
101510013753	phosphate binding motif [ion binding]; other site
101510013754	beta-alpha-beta structure motif; other site
101510013755	NAD binding pocket [chemical binding]; other site
101510013756	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510013757	Putative esterase; Region: Esterase; pfam00756
101510013758	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
101510013759	Clp amino terminal domain; Region: Clp_N; pfam02861
101510013760	Clp amino terminal domain; Region: Clp_N; pfam02861
101510013761	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
101510013762	Walker A motif; other site
101510013763	ATP binding site [chemical binding]; other site
101510013764	Walker B motif; other site
101510013765	arginine finger; other site
101510013766	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
101510013767	Walker A motif; other site
101510013768	ATP binding site [chemical binding]; other site
101510013769	Walker B motif; other site
101510013770	arginine finger; other site
101510013771	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
101510013772	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
101510013773	classical (c) SDRs; Region: SDR_c; cd05233
101510013774	NAD(P) binding site [chemical binding]; other site
101510013775	active site
101510013776	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
101510013777	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510013778	putative substrate translocation pore; other site
101510013779	Helix-turn-helix domains; Region: HTH; cl00088
101510013780	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
101510013781	hydrophobic ligand binding site; other site
101510013782	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510013783	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
101510013784	Domain of unknown function (DUF1992); Region: DUF1992; cl08096
101510013785	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
101510013786	Permease family; Region: Xan_ur_permease; cl00967
101510013787	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510013788	Helix-turn-helix domains; Region: HTH; cl00088
101510013789	YhhN-like protein; Region: YhhN; cl01505
101510013790	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
101510013791	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996
101510013792	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
101510013793	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
101510013794	active site
101510013795	non-prolyl cis peptide bond; other site
101510013796	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
101510013797	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510013798	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
101510013799	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
101510013800	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
101510013801	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
101510013802	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
101510013803	active site
101510013804	intersubunit interface [polypeptide binding]; other site
101510013805	zinc binding site [ion binding]; other site
101510013806	Na+ binding site [ion binding]; other site
101510013807	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510013808	Predicted membrane protein [Function unknown]; Region: COG4129
101510013809	Cation efflux family; Region: Cation_efflux; cl00316
101510013810	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
101510013811	Predicted transcriptional regulator [Transcription]; Region: COG2378
101510013812	Helix-turn-helix domains; Region: HTH; cl00088
101510013813	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
101510013814	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
101510013815	dimer interface [polypeptide binding]; other site
101510013816	active site
101510013817	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
101510013818	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510013819	putative substrate translocation pore; other site
101510013820	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
101510013821	Moco binding site; other site
101510013822	metal coordination site [ion binding]; other site
101510013823	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217
101510013824	FAD binding pocket [chemical binding]; other site
101510013825	FAD binding motif [chemical binding]; other site
101510013826	phosphate binding motif [ion binding]; other site
101510013827	beta-alpha-beta structure motif; other site
101510013828	NAD binding pocket [chemical binding]; other site
101510013829	Helix-turn-helix domains; Region: HTH; cl00088
101510013830	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
101510013831	active site
101510013832	putative substrate binding region [chemical binding]; other site
101510013833	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
101510013834	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
101510013835	GDP-binding site [chemical binding]; other site
101510013836	ACT binding site; other site
101510013837	IMP binding site; other site
101510013838	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
101510013839	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
101510013840	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
101510013841	active site
101510013842	DNA binding site [nucleotide binding]
101510013843	PhoD-like phosphatase; Region: PhoD; pfam09423
101510013844	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
101510013845	putative active site [active]
101510013846	putative metal binding site [ion binding]; other site
101510013847	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
101510013848	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
101510013849	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510013850	DNA-binding site [nucleotide binding]; DNA binding site
101510013851	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
101510013852	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510013853	homodimer interface [polypeptide binding]; other site
101510013854	catalytic residue [active]
101510013855	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
101510013856	CoA-transferase family III; Region: CoA_transf_3; pfam02515
101510013857	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
101510013858	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510013859	active site
101510013860	metal binding site [ion binding]; metal-binding site
101510013861	short chain dehydrogenase; Provisional; Region: PRK06197
101510013862	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
101510013863	putative NAD(P) binding site [chemical binding]; other site
101510013864	active site
101510013865	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
101510013866	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510013867	substrate binding pocket [chemical binding]; other site
101510013868	catalytic triad [active]
101510013869	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
101510013870	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510013871	substrate binding pocket [chemical binding]; other site
101510013872	catalytic triad [active]
101510013873	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
101510013874	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510013875	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
101510013876	short chain dehydrogenase; Provisional; Region: PRK08251
101510013877	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510013878	NAD(P) binding site [chemical binding]; other site
101510013879	active site
101510013880	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
101510013881	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510013882	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
101510013883	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
101510013884	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
101510013885	active site
101510013886	dimer interface [polypeptide binding]; other site
101510013887	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
101510013888	dimer interface [polypeptide binding]; other site
101510013889	active site
101510013890	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510013891	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
101510013892	tetramerization interface [polypeptide binding]; other site
101510013893	NAD(P) binding site [chemical binding]; other site
101510013894	catalytic residues [active]
101510013895	Chorismate mutase type II; Region: CM_2; cl00693
101510013896	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
101510013897	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510013898	Peptidase family M23; Region: Peptidase_M23; pfam01551
101510013899	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
101510013900	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
101510013901	CoA-ligase; Region: Ligase_CoA; pfam00549
101510013902	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
101510013903	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510013904	CoA-ligase; Region: Ligase_CoA; pfam00549
101510013905	Uncharacterized conserved protein [Function unknown]; Region: COG1739
101510013906	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
101510013907	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
101510013908	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
101510013909	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
101510013910	active site
101510013911	substrate binding site [chemical binding]; other site
101510013912	cosubstrate binding site; other site
101510013913	catalytic site [active]
101510013914	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
101510013915	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
101510013916	purine monophosphate binding site [chemical binding]; other site
101510013917	dimer interface [polypeptide binding]; other site
101510013918	putative catalytic residues [active]
101510013919	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
101510013920	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
101510013921	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
101510013922	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
101510013923	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
101510013924	active site
101510013925	metal binding site [ion binding]; metal-binding site
101510013926	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510013927	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510013928	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
101510013929	Helix-turn-helix domains; Region: HTH; cl00088
101510013930	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
101510013931	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510013932	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
101510013933	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510013934	Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867
101510013935	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
101510013936	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
101510013937	agmatine deiminase; Region: agmatine_aguA; TIGR03380
101510013938	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113
101510013939	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
101510013940	N-carbamolyputrescine amidase; Region: PLN02747
101510013941	active site
101510013942	catalytic triad [active]
101510013943	dimer interface [polypeptide binding]; other site
101510013944	tetracycline repressor protein TetR; Provisional; Region: PRK13756
101510013945	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
101510013946	Amino acid permease; Region: AA_permease; cl00524
101510013947	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
101510013948	Ligand Binding Site [chemical binding]; other site
101510013949	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
101510013950	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510013951	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
101510013952	tetramerization interface [polypeptide binding]; other site
101510013953	NAD(P) binding site [chemical binding]; other site
101510013954	catalytic residues [active]
101510013955	tyramine oxidase; Provisional; Region: tynA; PRK11504
101510013956	Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727
101510013957	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
101510013958	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
101510013959	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
101510013960	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
101510013961	inhibitor-cofactor binding pocket; inhibition site
101510013962	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510013963	catalytic residue [active]
101510013964	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510013965	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
101510013966	tetrameric interface [polypeptide binding]; other site
101510013967	NAD binding site [chemical binding]; other site
101510013968	catalytic residues [active]
101510013969	substrate binding site [chemical binding]; other site
101510013970	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
101510013971	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
101510013972	active site
101510013973	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
101510013974	Amino acid permease; Region: AA_permease; cl00524
101510013975	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
101510013976	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
101510013977	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
101510013978	active site
101510013979	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
101510013980	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
101510013981	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510013982	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
101510013983	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
101510013984	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510013985	Major Facilitator Superfamily; Region: MFS_1; pfam07690
101510013986	Membrane transport protein; Region: Mem_trans; cl09117
101510013987	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
101510013988	Domain of unknown function (DUF305); Region: DUF305; pfam03713
101510013989	Domain of unknown function (DUF305); Region: DUF305; pfam03713
101510013990	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
101510013991	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
101510013992	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
101510013993	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
101510013994	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
101510013995	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
101510013996	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
101510013997	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
101510013998	Predicted membrane protein [Function unknown]; Region: COG2860
101510013999	UPF0126 domain; Region: UPF0126; pfam03458
101510014000	UPF0126 domain; Region: UPF0126; pfam03458
101510014001	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
101510014002	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510014003	active site
101510014004	phosphorylation site [posttranslational modification]
101510014005	intermolecular recognition site; other site
101510014006	dimerization interface [polypeptide binding]; other site
101510014007	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
101510014008	DNA binding site [nucleotide binding]
101510014009	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
101510014010	dimerization interface [polypeptide binding]; other site
101510014011	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
101510014012	dimer interface [polypeptide binding]; other site
101510014013	phosphorylation site [posttranslational modification]
101510014014	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510014015	ATP binding site [chemical binding]; other site
101510014016	Mg2+ binding site [ion binding]; other site
101510014017	G-X-G motif; other site
101510014018	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
101510014019	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
101510014020	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
101510014021	MPT binding site; other site
101510014022	trimer interface [polypeptide binding]; other site
101510014023	MspA; Region: MspA; pfam09203
101510014024	MspA; Region: MspA; pfam09203
101510014025	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
101510014026	SAF domain; Region: SAF; cl00555
101510014027	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
101510014028	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
101510014029	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
101510014030	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
101510014031	active site
101510014032	tetramer interface; other site
101510014033	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
101510014034	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
101510014035	dimer interface [polypeptide binding]; other site
101510014036	putative functional site; other site
101510014037	putative MPT binding site; other site
101510014038	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
101510014039	Domain of unknown function (DUF955); Region: DUF955; cl01076
101510014040	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854
101510014041	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
101510014042	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
101510014043	Helix-turn-helix domains; Region: HTH; cl00088
101510014044	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
101510014045	short chain dehydrogenase; Provisional; Region: PRK05650
101510014046	classical (c) SDRs; Region: SDR_c; cd05233
101510014047	NAD(P) binding site [chemical binding]; other site
101510014048	active site
101510014049	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
101510014050	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
101510014051	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
101510014052	Walker A/P-loop; other site
101510014053	ATP binding site [chemical binding]; other site
101510014054	Q-loop/lid; other site
101510014055	ABC transporter signature motif; other site
101510014056	Walker B; other site
101510014057	D-loop; other site
101510014058	H-loop/switch region; other site
101510014059	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
101510014060	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
101510014061	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
101510014062	putative acyl-acceptor binding pocket; other site
101510014063	glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355
101510014064	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
101510014065	putative acyl-acceptor binding pocket; other site
101510014066	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
101510014067	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
101510014068	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
101510014069	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
101510014070	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
101510014071	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
101510014072	DNA binding residues [nucleotide binding]
101510014073	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
101510014074	heme-binding site [chemical binding]; other site
101510014075	Amidinotransferase; Region: Amidinotransf; cl12043
101510014076	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
101510014077	ArsC family; Region: ArsC; pfam03960
101510014078	catalytic residues [active]
101510014079	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510014080	NAD(P) binding site [chemical binding]; other site
101510014081	active site
101510014082	Predicted transcriptional regulators [Transcription]; Region: COG1725
101510014083	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510014084	DNA-binding site [nucleotide binding]; DNA binding site
101510014085	DoxX; Region: DoxX; cl00976
101510014086	BCCT family transporter; Region: BCCT; cl00569
101510014087	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364
101510014088	Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928
101510014089	Predicted methyltransferases [General function prediction only]; Region: COG0313
101510014090	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
101510014091	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
101510014092	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
101510014093	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
101510014094	active site
101510014095	HIGH motif; other site
101510014096	KMSKS motif; other site
101510014097	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
101510014098	tRNA binding surface [nucleotide binding]; other site
101510014099	anticodon binding site; other site
101510014100	short chain dehydrogenase; Provisional; Region: PRK07825
101510014101	classical (c) SDRs; Region: SDR_c; cd05233
101510014102	NAD(P) binding site [chemical binding]; other site
101510014103	active site
101510014104	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
101510014105	active site
101510014106	DoxX; Region: DoxX; cl00976
101510014107	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
101510014108	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
101510014109	Walker A/P-loop; other site
101510014110	ATP binding site [chemical binding]; other site
101510014111	Q-loop/lid; other site
101510014112	ABC transporter signature motif; other site
101510014113	Walker B; other site
101510014114	D-loop; other site
101510014115	H-loop/switch region; other site
101510014116	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
101510014117	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
101510014118	substrate binding pocket [chemical binding]; other site
101510014119	membrane-bound complex binding site; other site
101510014120	hinge residues; other site
101510014121	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
101510014122	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510014123	dimer interface [polypeptide binding]; other site
101510014124	conserved gate region; other site
101510014125	putative PBP binding loops; other site
101510014126	ABC-ATPase subunit interface; other site
101510014127	Domain of unknown function (DUF348); Region: DUF348; pfam03990
101510014128	Domain of unknown function (DUF348); Region: DUF348; pfam03990
101510014129	G5 domain; Region: G5; pfam07501
101510014130	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
101510014131	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
101510014132	Domain of unknown function (DUF348); Region: DUF348; pfam03990
101510014133	Domain of unknown function (DUF348); Region: DUF348; pfam03990
101510014134	Domain of unknown function (DUF348); Region: DUF348; pfam03990
101510014135	G5 domain; Region: G5; pfam07501
101510014136	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
101510014137	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510014138	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
101510014139	DNA-binding site [nucleotide binding]; DNA binding site
101510014140	RNA-binding motif; other site
101510014141	Predicted transcriptional regulator [Transcription]; Region: COG2378
101510014142	Helix-turn-helix domains; Region: HTH; cl00088
101510014143	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
101510014144	putative active site [active]
101510014145	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
101510014146	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
101510014147	alpha-gamma subunit interface [polypeptide binding]; other site
101510014148	beta-gamma subunit interface [polypeptide binding]; other site
101510014149	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
101510014150	gamma-beta subunit interface [polypeptide binding]; other site
101510014151	alpha-beta subunit interface [polypeptide binding]; other site
101510014152	urease subunit alpha; Reviewed; Region: ureC; PRK13206
101510014153	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
101510014154	subunit interactions [polypeptide binding]; other site
101510014155	active site
101510014156	flap region; other site
101510014157	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
101510014158	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510014159	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
101510014160	GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256
101510014161	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
101510014162	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
101510014163	ABC transporter; Region: ABC_tran_2; pfam12848
101510014164	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
101510014165	Domain of unknown function (DUF3552); Region: DUF3552; pfam12072
101510014166	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
101510014167	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
101510014168	active site
101510014169	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510014170	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
101510014171	putative dimer interface [polypeptide binding]; other site
101510014172	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510014173	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
101510014174	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
101510014175	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
101510014176	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
101510014177	RF3 subfamily.  Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria.  Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169
101510014178	G1 box; other site
101510014179	putative GEF interaction site [polypeptide binding]; other site
101510014180	GTP/Mg2+ binding site [chemical binding]; other site
101510014181	Switch I region; other site
101510014182	G2 box; other site
101510014183	G3 box; other site
101510014184	Switch II region; other site
101510014185	G4 box; other site
101510014186	G5 box; other site
101510014187	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
101510014188	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
101510014189	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510014190	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
101510014191	putative active site [active]
101510014192	catalytic residue [active]
101510014193	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
101510014194	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
101510014195	5S rRNA interface [nucleotide binding]; other site
101510014196	CTC domain interface [polypeptide binding]; other site
101510014197	L16 interface [polypeptide binding]; other site
101510014198	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
101510014199	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510014200	GAF domain; Region: GAF; cl00853
101510014201	hypothetical protein; Validated; Region: PRK07121
101510014202	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510014203	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
101510014204	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
101510014205	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
101510014206	catalytic residue [active]
101510014207	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
101510014208	TIGR03440 family protein; Region: unchr_TIGR03440
101510014209	DinB superfamily; Region: DinB_2; cl00986
101510014210	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
101510014211	TIGR03442 family protein; Region: TIGR03442
101510014212	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
101510014213	putative active site [active]
101510014214	putative dimer interface [polypeptide binding]; other site
101510014215	probable methyltransferase; Region: TIGR03438
101510014216	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
101510014217	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
101510014218	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
101510014219	Putative cyclase; Region: Cyclase; cl00814
101510014220	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510014221	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
101510014222	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510014223	Sodium:solute symporter family; Region: SSF; cl00456
101510014224	Sodium:solute symporter family; Region: SSF; cl00456
101510014225	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
101510014226	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
101510014227	putative active site [active]
101510014228	putative FMN binding site [chemical binding]; other site
101510014229	putative substrate binding site [chemical binding]; other site
101510014230	putative catalytic residue [active]
101510014231	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510014232	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
101510014233	Helix-turn-helix domains; Region: HTH; cl00088
101510014234	hypothetical protein; Provisional; Region: PRK07524
101510014235	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
101510014236	PYR/PP interface [polypeptide binding]; other site
101510014237	dimer interface [polypeptide binding]; other site
101510014238	TPP binding site [chemical binding]; other site
101510014239	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
101510014240	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
101510014241	TPP-binding site [chemical binding]; other site
101510014242	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510014243	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510014244	active site
101510014245	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
101510014246	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510014247	NAD binding site [chemical binding]; other site
101510014248	catalytic residues [active]
101510014249	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
101510014250	short chain dehydrogenase; Provisional; Region: PRK07677
101510014251	NAD(P) binding site [chemical binding]; other site
101510014252	substrate binding site [chemical binding]; other site
101510014253	homotetramer interface [polypeptide binding]; other site
101510014254	active site
101510014255	homodimer interface [polypeptide binding]; other site
101510014256	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
101510014257	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510014258	Amino acid permease; Region: AA_permease; cl00524
101510014259	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510014260	Helix-turn-helix domains; Region: HTH; cl00088
101510014261	Cytochrome P450; Region: p450; cl12078
101510014262	Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374
101510014263	Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462
101510014264	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
101510014265	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
101510014266	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
101510014267	Substrate binding site; other site
101510014268	Mg++ binding site; other site
101510014269	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
101510014270	active site
101510014271	substrate binding site [chemical binding]; other site
101510014272	CoA binding site [chemical binding]; other site
101510014273	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510014274	Helix-turn-helix domains; Region: HTH; cl00088
101510014275	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510014276	Helix-turn-helix domains; Region: HTH; cl00088
101510014277	glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209
101510014278	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
101510014279	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
101510014280	catalytic residue [active]
101510014281	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156
101510014282	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
101510014283	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
101510014284	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
101510014285	putative ADP-binding pocket [chemical binding]; other site
101510014286	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
101510014287	putative active site [active]
101510014288	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
101510014289	Chain length determinant protein; Region: Wzz; cl01623
101510014290	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
101510014291	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
101510014292	MatE; Region: MatE; cl10513
101510014293	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
101510014294	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
101510014295	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
101510014296	active site
101510014297	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
101510014298	Bacterial sugar transferase; Region: Bac_transf; cl00939
101510014299	Hypothetical methyltransferase; Region: Methyltransf_13; pfam08421
101510014300	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
101510014301	Cupin domain; Region: Cupin_2; cl09118
101510014302	extended (e) SDRs; Region: SDR_e; cd08946
101510014303	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
101510014304	NAD(P) binding site [chemical binding]; other site
101510014305	active site
101510014306	substrate binding site [chemical binding]; other site
101510014307	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
101510014308	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
101510014309	active site
101510014310	Hypothetical methyltransferase; Region: Methyltransf_13; pfam08421
101510014311	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510014312	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
101510014313	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368
101510014314	hypothetical protein; Provisional; Region: PRK07877
101510014315	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
101510014316	ATP binding site [chemical binding]; other site
101510014317	substrate interface [chemical binding]; other site
101510014318	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
101510014319	metal binding site [ion binding]; metal-binding site
101510014320	active site
101510014321	I-site; other site
101510014322	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
101510014323	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
101510014324	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510014325	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510014326	Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670
101510014327	dimer interface [polypeptide binding]; other site
101510014328	motif 1; other site
101510014329	active site
101510014330	motif 2; other site
101510014331	motif 3; other site
101510014332	Domain of unknown function (DUF1839); Region: DUF1839; pfam08893
101510014333	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
101510014334	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
101510014335	CarD-like/TRCF domain; Region: CarD_TRCF; cl00588
101510014336	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
101510014337	ATP binding site [chemical binding]; other site
101510014338	putative Mg++ binding site [ion binding]; other site
101510014339	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
101510014340	nucleotide binding region [chemical binding]; other site
101510014341	ATP-binding site [chemical binding]; other site
101510014342	TRCF domain; Region: TRCF; cl04088
101510014343	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334
101510014344	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
101510014345	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
101510014346	Ligand binding site; other site
101510014347	Putative Catalytic site; other site
101510014348	DXD motif; other site
101510014349	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
101510014350	DXD motif; other site
101510014351	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
101510014352	Probable Catalytic site; other site
101510014353	metal-binding site
101510014354	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510014355	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
101510014356	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
101510014357	active site
101510014358	catalytic residues [active]
101510014359	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
101510014360	active site
101510014361	catalytic residues [active]
101510014362	Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571
101510014363	putative catalytic motif [active]
101510014364	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
101510014365	metal binding site [ion binding]; metal-binding site
101510014366	active site
101510014367	I-site; other site
101510014368	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
101510014369	metal binding site [ion binding]; metal-binding site
101510014370	active site
101510014371	I-site; other site
101510014372	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
101510014373	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
101510014374	Imelysin; Region: Peptidase_M75; cl09159
101510014375	Iron permease FTR1 family; Region: FTR1; cl00475
101510014376	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
101510014377	enolase; Provisional; Region: eno; PRK00077
101510014378	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
101510014379	dimer interface [polypeptide binding]; other site
101510014380	metal binding site [ion binding]; metal-binding site
101510014381	substrate binding pocket [chemical binding]; other site
101510014382	Septum formation initiator; Region: DivIC; cl11433
101510014383	Protein of unknown function (DUF501); Region: DUF501; cl00652
101510014384	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
101510014385	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
101510014386	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510014387	S-adenosylmethionine binding site [chemical binding]; other site
101510014388	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
101510014389	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
101510014390	putative active site [active]
101510014391	putative metal binding site [ion binding]; other site
101510014392	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
101510014393	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510014394	Transcriptional regulators [Transcription]; Region: MarR; COG1846
101510014395	Helix-turn-helix domains; Region: HTH; cl00088
101510014396	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510014397	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510014398	NAD(P) binding site [chemical binding]; other site
101510014399	active site
101510014400	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
101510014401	classical (c) SDRs; Region: SDR_c; cd05233
101510014402	NAD(P) binding site [chemical binding]; other site
101510014403	active site
101510014404	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510014405	NAD(P) binding site [chemical binding]; other site
101510014406	active site
101510014407	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510014408	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
101510014409	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510014410	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
101510014411	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510014412	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510014413	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510014414	Helix-turn-helix domains; Region: HTH; cl00088
101510014415	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510014416	Flavin Reductases; Region: FlaRed; cl00801
101510014417	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
101510014418	homoserine O-acetyltransferase; Provisional; Region: metX; cl15472
101510014419	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835
101510014420	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510014421	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
101510014422	acetaldehyde dehydrogenase; Validated; Region: PRK08300
101510014423	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510014424	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
101510014425	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
101510014426	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
101510014427	active site
101510014428	catalytic residues [active]
101510014429	metal binding site [ion binding]; metal-binding site
101510014430	DmpG-like communication domain; Region: DmpG_comm; pfam07836
101510014431	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510014432	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510014433	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
101510014434	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
101510014435	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
101510014436	active site
101510014437	Fe binding site [ion binding]; other site
101510014438	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510014439	Secretory lipase; Region: LIP; pfam03583
101510014440	Domain of unknown function (DUF427); Region: DUF427; cl00998
101510014441	Domain of unknown function (DUF427); Region: DUF427; cl00998
101510014442	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
101510014443	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510014444	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
101510014445	classical (c) SDRs; Region: SDR_c; cd05233
101510014446	NAD(P) binding site [chemical binding]; other site
101510014447	active site
101510014448	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510014449	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510014450	NAD(P) binding site [chemical binding]; other site
101510014451	active site
101510014452	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
101510014453	The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH).  The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531
101510014454	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
101510014455	hydrophobic ligand binding site; other site
101510014456	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510014457	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510014458	active site
101510014459	3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837
101510014460	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510014461	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510014462	Helix-turn-helix domains; Region: HTH; cl00088
101510014463	acetyl-CoA acetyltransferase; Provisional; Region: PRK07850
101510014464	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
101510014465	dimer interface [polypeptide binding]; other site
101510014466	active site
101510014467	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510014468	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510014469	active site
101510014470	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510014471	active site
101510014472	enoyl-CoA hydratase; Region: PLN02864
101510014473	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
101510014474	dimer interaction site [polypeptide binding]; other site
101510014475	substrate-binding tunnel; other site
101510014476	active site
101510014477	catalytic site [active]
101510014478	substrate binding site [chemical binding]; other site
101510014479	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
101510014480	CoenzymeA binding site [chemical binding]; other site
101510014481	subunit interaction site [polypeptide binding]; other site
101510014482	PHB binding site; other site
101510014483	classical (c) SDRs; Region: SDR_c; cd05233
101510014484	NAD(P) binding site [chemical binding]; other site
101510014485	active site
101510014486	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
101510014487	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510014488	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
101510014489	active site
101510014490	FMN binding site [chemical binding]; other site
101510014491	substrate binding site [chemical binding]; other site
101510014492	putative catalytic residue [active]
101510014493	acyl-CoA synthetase; Provisional; Region: PRK13388
101510014494	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510014495	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
101510014496	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510014497	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510014498	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510014499	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510014500	active site
101510014501	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
101510014502	DUF35 OB-fold domain; Region: DUF35; pfam01796
101510014503	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510014504	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510014505	active site
101510014506	SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  The alpha- and...; Region: SAV4209; cd03455
101510014507	putative active site [active]
101510014508	putative catalytic site [active]
101510014509	lipid-transfer protein; Provisional; Region: PRK07855
101510014510	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
101510014511	active site
101510014512	enoyl-CoA hydratase; Region: PLN02864
101510014513	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
101510014514	active site 2 [active]
101510014515	active site 1 [active]
101510014516	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
101510014517	classical (c) SDRs; Region: SDR_c; cd05233
101510014518	NAD(P) binding site [chemical binding]; other site
101510014519	active site
101510014520	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
101510014521	classical (c) SDRs; Region: SDR_c; cd05233
101510014522	NAD(P) binding site [chemical binding]; other site
101510014523	active site
101510014524	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
101510014525	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
101510014526	FAD binding pocket [chemical binding]; other site
101510014527	FAD binding motif [chemical binding]; other site
101510014528	phosphate binding motif [ion binding]; other site
101510014529	beta-alpha-beta structure motif; other site
101510014530	NAD(p) ribose binding residues [chemical binding]; other site
101510014531	NAD binding pocket [chemical binding]; other site
101510014532	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
101510014533	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510014534	catalytic loop [active]
101510014535	iron binding site [ion binding]; other site
101510014536	TIGR03442 family protein; Region: TIGR03442
101510014537	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
101510014538	putative active site [active]
101510014539	putative dimer interface [polypeptide binding]; other site
101510014540	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
101510014541	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
101510014542	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
101510014543	tetramer interface [polypeptide binding]; other site
101510014544	heme binding pocket [chemical binding]; other site
101510014545	NADPH binding site [chemical binding]; other site
101510014546	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510014547	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510014548	active site
101510014549	ATP binding site [chemical binding]; other site
101510014550	substrate binding site [chemical binding]; other site
101510014551	activation loop (A-loop); other site
101510014552	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
101510014553	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
101510014554	putative FMN binding site [chemical binding]; other site
101510014555	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
101510014556	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510014557	S-adenosylmethionine binding site [chemical binding]; other site
101510014558	BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473
101510014559	acetyl-CoA acetyltransferase; Provisional; Region: PRK07851
101510014560	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
101510014561	dimer interface [polypeptide binding]; other site
101510014562	active site
101510014563	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
101510014564	active site
101510014565	catalytic triad [active]
101510014566	oxyanion hole [active]
101510014567	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
101510014568	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
101510014569	dimer interface [polypeptide binding]; other site
101510014570	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510014571	catalytic residue [active]
101510014572	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
101510014573	cystathionine gamma-synthase; Provisional; Region: PRK07811
101510014574	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
101510014575	homodimer interface [polypeptide binding]; other site
101510014576	substrate-cofactor binding pocket; other site
101510014577	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510014578	catalytic residue [active]
101510014579	threonine dehydratase; Provisional; Region: PRK08198
101510014580	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
101510014581	tetramer interface [polypeptide binding]; other site
101510014582	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510014583	catalytic residue [active]
101510014584	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
101510014585	ApbE family; Region: ApbE; cl00643
101510014586	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
101510014587	N-acetyl-D-glucosamine binding site [chemical binding]; other site
101510014588	catalytic residue [active]
101510014589	NlpC/P60 family; Region: NLPC_P60; cl11438
101510014590	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
101510014591	domain; Region: GreA_GreB_N; pfam03449
101510014592	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
101510014593	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
101510014594	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
101510014595	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
101510014596	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
101510014597	catalytic residues [active]
101510014598	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
101510014599	Haemolysin-III related; Region: HlyIII; cl03831
101510014600	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
101510014601	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
101510014602	catalytic residue [active]
101510014603	putative FPP diphosphate  binding site; other site
101510014604	putative FPP binding hydrophobic cleft; other site
101510014605	dimer interface [polypeptide binding]; other site
101510014606	putative IPP diphosphate binding site; other site
101510014607	pantothenate kinase; Provisional; Region: PRK05439
101510014608	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025
101510014609	ATP-binding site [chemical binding]; other site
101510014610	CoA-binding site [chemical binding]; other site
101510014611	Mg2+-binding site [ion binding]; other site
101510014612	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
101510014613	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
101510014614	dimer interface [polypeptide binding]; other site
101510014615	glycine-pyridoxal phosphate binding site [chemical binding]; other site
101510014616	active site
101510014617	folate binding site [chemical binding]; other site
101510014618	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
101510014619	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
101510014620	putative active site [active]
101510014621	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510014622	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510014623	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
101510014624	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
101510014625	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
101510014626	dinuclear metal binding motif [ion binding]; other site
101510014627	fumarate hydratase; Reviewed; Region: fumC; PRK00485
101510014628	Class II fumarases; Region: Fumarase_classII; cd01362
101510014629	active site
101510014630	tetramer interface [polypeptide binding]; other site
101510014631	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
101510014632	putative active site [active]
101510014633	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
101510014634	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
101510014635	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
101510014636	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
101510014637	generic binding surface II; other site
101510014638	generic binding surface I; other site
101510014639	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700
101510014640	LytB protein; Region: LYTB; cl00507
101510014641	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
101510014642	RmuC family; Region: RmuC; pfam02646
101510014643	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
101510014644	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
101510014645	active site
101510014646	metal binding site [ion binding]; metal-binding site
101510014647	DNA binding site [nucleotide binding]
101510014648	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
101510014649	chromosome segregation protein; Provisional; Region: PRK02224
101510014650	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510014651	Walker A/P-loop; other site
101510014652	ATP binding site [chemical binding]; other site
101510014653	Q-loop/lid; other site
101510014654	exonuclease SbcC; Region: sbcc; TIGR00618
101510014655	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510014656	Walker B; other site
101510014657	D-loop; other site
101510014658	H-loop/switch region; other site
101510014659	Domain of unknown function DUF20; Region: UPF0118; cl00465
101510014660	Carbon starvation protein CstA; Region: CstA; cl00856
101510014661	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
101510014662	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
101510014663	active site
101510014664	FMN binding site [chemical binding]; other site
101510014665	substrate binding site [chemical binding]; other site
101510014666	3Fe-4S cluster binding site [ion binding]; other site
101510014667	Interferon-induced transmembrane protein; Region: CD225; pfam04505
101510014668	GTP-binding protein YchF; Reviewed; Region: PRK09601
101510014669	YchF subfamily.  YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1.  Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900
101510014670	G1 box; other site
101510014671	GTP/Mg2+ binding site [chemical binding]; other site
101510014672	Switch I region; other site
101510014673	G2 box; other site
101510014674	Switch II region; other site
101510014675	G3 box; other site
101510014676	G4 box; other site
101510014677	G5 box; other site
101510014678	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
101510014679	Helix-turn-helix domains; Region: HTH; cl00088
101510014680	Cutinase; Region: Cutinase; cl15711
101510014681	Protein of unknown function (DUF1304); Region: DUF1304; cl01533
101510014682	Cupin domain; Region: Cupin_2; cl09118
101510014683	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510014684	DNA binding residues [nucleotide binding]
101510014685	dimerization interface [polypeptide binding]; other site
101510014686	Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase).  The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA.  This is an example of molecular mimicry; a protein domain evolved so...; Region: EF-G_bact; cd04170
101510014687	elongation factor G; Reviewed; Region: PRK12740
101510014688	G1 box; other site
101510014689	putative GEF interaction site [polypeptide binding]; other site
101510014690	GTP/Mg2+ binding site [chemical binding]; other site
101510014691	Switch I region; other site
101510014692	G2 box; other site
101510014693	G3 box; other site
101510014694	Switch II region; other site
101510014695	G4 box; other site
101510014696	G5 box; other site
101510014697	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
101510014698	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
101510014699	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
101510014700	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818
101510014701	putative hydrophobic ligand binding site [chemical binding]; other site
101510014702	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
101510014703	putative active site [active]
101510014704	putative metal binding site [ion binding]; other site
101510014705	Fic/DOC family; Region: Fic; cl00960
101510014706	Domain of unknown function (DUF4287); Region: DUF4287; pfam14117
101510014707	heat shock protein 90; Provisional; Region: PRK05218
101510014708	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
101510014709	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
101510014710	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510014711	NAD(P) binding site [chemical binding]; other site
101510014712	active site
101510014713	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
101510014714	active site
101510014715	SUMO-1 interface [polypeptide binding]; other site
101510014716	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510014717	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510014718	active site
101510014719	hypothetical protein; Provisional; Region: PRK08317
101510014720	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510014721	S-adenosylmethionine binding site [chemical binding]; other site
101510014722	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
101510014723	fumarate hydratase; Provisional; Region: PRK15389
101510014724	Fumarate hydratase (Fumerase); Region: Fumerase; cl00851
101510014725	Fumarase C-terminus; Region: Fumerase_C; cl00795
101510014726	CAAX amino terminal protease self- immunity; Region: Abi; cl00558
101510014727	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510014728	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
101510014729	ligand binding site [chemical binding]; other site
101510014730	Old yellow enzyme (OYE)-related FMN binding domain, group 5.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747
101510014731	putative active site [active]
101510014732	putative FMN binding site [chemical binding]; other site
101510014733	putative substrate binding site [chemical binding]; other site
101510014734	putative catalytic residue [active]
101510014735	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
101510014736	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
101510014737	active site
101510014738	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
101510014739	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
101510014740	Cl- selectivity filter; other site
101510014741	Cl- binding residues [ion binding]; other site
101510014742	pore gating glutamate residue; other site
101510014743	dimer interface [polypeptide binding]; other site
101510014744	Restriction endonuclease; Region: Mrr_cat; cl00747
101510014745	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
101510014746	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
101510014747	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
101510014748	active site
101510014749	phosphorylation site [posttranslational modification]
101510014750	intermolecular recognition site; other site
101510014751	dimerization interface [polypeptide binding]; other site
101510014752	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
101510014753	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419
101510014754	NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; cl00365
101510014755	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
101510014756	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346
101510014757	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
101510014758	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
101510014759	putative dimer interface [polypeptide binding]; other site
101510014760	[2Fe-2S] cluster binding site [ion binding]; other site
101510014761	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
101510014762	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
101510014763	SLBB domain; Region: SLBB; pfam10531
101510014764	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
101510014765	NADH dehydrogenase subunit G; Validated; Region: PRK07860
101510014766	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510014767	catalytic loop [active]
101510014768	iron binding site [ion binding]; other site
101510014769	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
101510014770	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
101510014771	molybdopterin cofactor binding site; other site
101510014772	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
101510014773	NADH dehydrogenase; Region: NADHdh; cl00469
101510014774	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
101510014775	4Fe-4S binding domain; Region: Fer4; cl02805
101510014776	4Fe-4S binding domain; Region: Fer4; cl02805
101510014777	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
101510014778	NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634
101510014779	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
101510014780	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
101510014781	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
101510014782	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
101510014783	proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972
101510014784	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
101510014785	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
101510014786	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
101510014787	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
101510014788	active site
101510014789	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510014790	Helix-turn-helix domains; Region: HTH; cl00088
101510014791	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
101510014792	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
101510014793	aromatic arch; other site
101510014794	DCoH dimer interaction site [polypeptide binding]; other site
101510014795	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
101510014796	DCoH tetramer interaction site [polypeptide binding]; other site
101510014797	substrate binding site [chemical binding]; other site
101510014798	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
101510014799	active site
101510014800	8-oxo-dGMP binding site [chemical binding]; other site
101510014801	nudix motif; other site
101510014802	metal binding site [ion binding]; metal-binding site
101510014803	TypA (tyrosine phosphorylated protein A)/BipA subfamily.  BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants.  BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891
101510014804	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
101510014805	G1 box; other site
101510014806	putative GEF interaction site [polypeptide binding]; other site
101510014807	GTP/Mg2+ binding site [chemical binding]; other site
101510014808	Switch I region; other site
101510014809	G2 box; other site
101510014810	G3 box; other site
101510014811	Switch II region; other site
101510014812	G4 box; other site
101510014813	G5 box; other site
101510014814	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
101510014815	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
101510014816	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
101510014817	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
101510014818	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
101510014819	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
101510014820	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
101510014821	tetramer interface [polypeptide binding]; other site
101510014822	heme binding pocket [chemical binding]; other site
101510014823	NADPH binding site [chemical binding]; other site
101510014824	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
101510014825	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
101510014826	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
101510014827	active site
101510014828	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
101510014829	Fe-S cluster binding site [ion binding]; other site
101510014830	DNA binding site [nucleotide binding]
101510014831	active site
101510014832	Predicted membrane protein [Function unknown]; Region: COG3428
101510014833	Bacterial membrane flanked domain; Region: DUF304; cl01348
101510014834	Bacterial membrane flanked domain; Region: DUF304; cl01348
101510014835	FO synthase; Reviewed; Region: fbiC; PRK09234
101510014836	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
101510014837	FeS/SAM binding site; other site
101510014838	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
101510014839	FeS/SAM binding site; other site
101510014840	[FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105
101510014841	4Fe-4S binding domain; Region: Fer4; cl02805
101510014842	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
101510014843	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
101510014844	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510014845	homodimer interface [polypeptide binding]; other site
101510014846	catalytic residue [active]
101510014847	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
101510014848	Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123
101510014849	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510014850	Glutamate binding site [chemical binding]; other site
101510014851	NAD binding site [chemical binding]; other site
101510014852	catalytic residues [active]
101510014853	Proline dehydrogenase; Region: Pro_dh; cl03282
101510014854	acyl-CoA synthetase; Validated; Region: PRK07787
101510014855	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510014856	Prostaglandin dehydrogenases; Region: PGDH; cd05288
101510014857	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
101510014858	NAD(P) binding site [chemical binding]; other site
101510014859	substrate binding site [chemical binding]; other site
101510014860	dimer interface [polypeptide binding]; other site
101510014861	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
101510014862	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
101510014863	metal ion-dependent adhesion site (MIDAS); other site
101510014864	Sulfatase; Region: Sulfatase; cl10460
101510014865	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
101510014866	Protein of unknown function (DUF1622); Region: DUF1622; cl01991
101510014867	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
101510014868	Amino acid permease; Region: AA_permease; cl00524
101510014869	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
101510014870	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
101510014871	putative trimer interface [polypeptide binding]; other site
101510014872	putative CoA binding site [chemical binding]; other site
101510014873	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651
101510014874	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
101510014875	metal binding site [ion binding]; metal-binding site
101510014876	putative dimer interface [polypeptide binding]; other site
101510014877	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
101510014878	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
101510014879	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
101510014880	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510014881	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510014882	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
101510014883	dihydropteroate synthase; Region: DHPS; TIGR01496
101510014884	substrate binding pocket [chemical binding]; other site
101510014885	dimer interface [polypeptide binding]; other site
101510014886	inhibitor binding site; inhibition site
101510014887	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
101510014888	active site
101510014889	DivIVA domain; Region: DivI1A_domain; TIGR03544
101510014890	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
101510014891	Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
101510014892	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
101510014893	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510014894	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
101510014895	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
101510014896	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
101510014897	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
101510014898	ligand binding site; other site
101510014899	oligomer interface; other site
101510014900	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
101510014901	dimer interface [polypeptide binding]; other site
101510014902	N-terminal domain interface [polypeptide binding]; other site
101510014903	sulfate 1 binding site; other site
101510014904	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510014905	S-adenosylmethionine binding site [chemical binding]; other site
101510014906	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
101510014907	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
101510014908	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
101510014909	DNA binding residues [nucleotide binding]
101510014910	Putative zinc-finger; Region: zf-HC2; cl15806
101510014911	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
101510014912	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
101510014913	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
101510014914	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
101510014915	Domain of unknown function DUF59; Region: DUF59; cl00941
101510014916	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
101510014917	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
101510014918	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
101510014919	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
101510014920	N-acetyl-D-glucosamine binding site [chemical binding]; other site
101510014921	catalytic residue [active]
101510014922	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
101510014923	N-acetyl-D-glucosamine binding site [chemical binding]; other site
101510014924	Protein of unknown function (DUF1003); Region: DUF1003; cl01831
101510014925	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
101510014926	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
101510014927	MgtE intracellular N domain; Region: MgtE_N; cl15244
101510014928	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
101510014929	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
101510014930	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
101510014931	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510014932	dimer interface [polypeptide binding]; other site
101510014933	conserved gate region; other site
101510014934	putative PBP binding loops; other site
101510014935	ABC-ATPase subunit interface; other site
101510014936	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510014937	dimer interface [polypeptide binding]; other site
101510014938	conserved gate region; other site
101510014939	putative PBP binding loops; other site
101510014940	ABC-ATPase subunit interface; other site
101510014941	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
101510014942	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
101510014943	Walker A/P-loop; other site
101510014944	ATP binding site [chemical binding]; other site
101510014945	Q-loop/lid; other site
101510014946	ABC transporter signature motif; other site
101510014947	Walker B; other site
101510014948	D-loop; other site
101510014949	H-loop/switch region; other site
101510014950	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510014951	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
101510014952	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
101510014953	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
101510014954	active site
101510014955	metal binding site [ion binding]; metal-binding site
101510014956	Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403
101510014957	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
101510014958	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
101510014959	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
101510014960	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
101510014961	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
101510014962	Malic enzyme, N-terminal domain; Region: malic; pfam00390
101510014963	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510014964	NAD(P) binding pocket [chemical binding]; other site
101510014965	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
101510014966	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
101510014967	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
101510014968	OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment.  ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295
101510014969	Walker A/P-loop; other site
101510014970	ATP binding site [chemical binding]; other site
101510014971	Q-loop/lid; other site
101510014972	ABC transporter signature motif; other site
101510014973	Walker B; other site
101510014974	D-loop; other site
101510014975	H-loop/switch region; other site
101510014976	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
101510014977	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
101510014978	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
101510014979	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
101510014980	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510014981	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
101510014982	short chain dehydrogenase; Provisional; Region: PRK07825
101510014983	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510014984	NAD(P) binding site [chemical binding]; other site
101510014985	active site
101510014986	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
101510014987	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510014988	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510014989	Helix-turn-helix domains; Region: HTH; cl00088
101510014990	Predicted ATPase [General function prediction only]; Region: COG3910
101510014991	ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules.  The...; Region: ABC_ATPase; cd00267
101510014992	Walker A/P-loop; other site
101510014993	ATP binding site [chemical binding]; other site
101510014994	Q-loop/lid; other site
101510014995	ABC transporter signature motif; other site
101510014996	Walker B; other site
101510014997	D-loop; other site
101510014998	H-loop/switch region; other site
101510014999	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
101510015000	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
101510015001	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
101510015002	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
101510015003	TPP-binding site [chemical binding]; other site
101510015004	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
101510015005	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
101510015006	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
101510015007	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510015008	Walker A/P-loop; other site
101510015009	ATP binding site [chemical binding]; other site
101510015010	Q-loop/lid; other site
101510015011	ABC transporter signature motif; other site
101510015012	Walker B; other site
101510015013	D-loop; other site
101510015014	H-loop/switch region; other site
101510015015	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
101510015016	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
101510015017	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510015018	Walker A/P-loop; other site
101510015019	ATP binding site [chemical binding]; other site
101510015020	Q-loop/lid; other site
101510015021	ABC transporter signature motif; other site
101510015022	Walker B; other site
101510015023	D-loop; other site
101510015024	H-loop/switch region; other site
101510015025	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
101510015026	The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance.  Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis.  The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268
101510015027	Walker A/P-loop; other site
101510015028	ATP binding site [chemical binding]; other site
101510015029	Q-loop/lid; other site
101510015030	ABC transporter signature motif; other site
101510015031	Walker B; other site
101510015032	D-loop; other site
101510015033	H-loop/switch region; other site
101510015034	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
101510015035	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
101510015036	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
101510015037	catalytic residue [active]
101510015038	Helix-turn-helix domain; Region: HTH_18; pfam12833
101510015039	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355
101510015040	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510015041	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
101510015042	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
101510015043	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
101510015044	putative dimer interface [polypeptide binding]; other site
101510015045	N-terminal domain interface [polypeptide binding]; other site
101510015046	putative substrate binding pocket (H-site) [chemical binding]; other site
101510015047	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
101510015048	Helix-turn-helix domains; Region: HTH; cl00088
101510015049	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510015050	Major Facilitator Superfamily; Region: MFS_1; pfam07690
101510015051	putative substrate translocation pore; other site
101510015052	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
101510015053	FAD binding domain; Region: FAD_binding_4; pfam01565
101510015054	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
101510015055	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510015056	substrate binding site [chemical binding]; other site
101510015057	oxyanion hole (OAH) forming residues; other site
101510015058	trimer interface [polypeptide binding]; other site
101510015059	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
101510015060	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
101510015061	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
101510015062	active site
101510015063	purine riboside binding site [chemical binding]; other site
101510015064	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
101510015065	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
101510015066	FAD binding domain; Region: FAD_binding_4; pfam01565
101510015067	D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370
101510015068	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510015069	Helix-turn-helix domains; Region: HTH; cl00088
101510015070	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813
101510015071	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
101510015072	dimer interface [polypeptide binding]; other site
101510015073	active site
101510015074	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
101510015075	substrate binding site [chemical binding]; other site
101510015076	catalytic residue [active]
101510015077	Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251
101510015078	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
101510015079	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510015080	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
101510015081	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510015082	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510015083	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
101510015084	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510015085	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
101510015086	Predicted amidohydrolase [General function prediction only]; Region: COG0388
101510015087	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
101510015088	putative active site [active]
101510015089	catalytic triad [active]
101510015090	putative dimer interface [polypeptide binding]; other site
101510015091	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
101510015092	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
101510015093	ATP binding site [chemical binding]; other site
101510015094	Mg++ binding site [ion binding]; other site
101510015095	motif III; other site
101510015096	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
101510015097	nucleotide binding region [chemical binding]; other site
101510015098	ATP-binding site [chemical binding]; other site
101510015099	DbpA RNA binding domain; Region: DbpA; pfam03880
101510015100	DinB superfamily; Region: DinB_2; cl00986
101510015101	trehalose synthase; Region: treS_nterm; TIGR02456
101510015102	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
101510015103	active site
101510015104	catalytic site [active]
101510015105	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286
101510015106	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
101510015107	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
101510015108	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510015109	Walker A/P-loop; other site
101510015110	ATP binding site [chemical binding]; other site
101510015111	Q-loop/lid; other site
101510015112	ABC transporter signature motif; other site
101510015113	Walker B; other site
101510015114	D-loop; other site
101510015115	H-loop/switch region; other site
101510015116	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012
101510015117	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
101510015118	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510015119	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
101510015120	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
101510015121	Walker A/P-loop; other site
101510015122	ATP binding site [chemical binding]; other site
101510015123	Q-loop/lid; other site
101510015124	ABC transporter signature motif; other site
101510015125	Walker B; other site
101510015126	D-loop; other site
101510015127	H-loop/switch region; other site
101510015128	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
101510015129	FtsX-like permease family; Region: FtsX; pfam02687
101510015130	FtsX-like permease family; Region: FtsX; pfam02687
101510015131	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
101510015132	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510015133	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510015134	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
101510015135	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510015136	Helix-turn-helix domains; Region: HTH; cl00088
101510015137	A new structural DNA glycosylase; Region: AlkD_like; cd06561
101510015138	active site
101510015139	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
101510015140	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
101510015141	FAD binding pocket [chemical binding]; other site
101510015142	FAD binding motif [chemical binding]; other site
101510015143	phosphate binding motif [ion binding]; other site
101510015144	beta-alpha-beta structure motif; other site
101510015145	NAD(p) ribose binding residues [chemical binding]; other site
101510015146	NAD binding pocket [chemical binding]; other site
101510015147	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
101510015148	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510015149	catalytic loop [active]
101510015150	iron binding site [ion binding]; other site
101510015151	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
101510015152	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
101510015153	dimer interface [polypeptide binding]; other site
101510015154	active site
101510015155	metal binding site [ion binding]; metal-binding site
101510015156	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
101510015157	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
101510015158	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
101510015159	Walker A motif; other site
101510015160	ATP binding site [chemical binding]; other site
101510015161	Walker B motif; other site
101510015162	arginine finger; other site
101510015163	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
101510015164	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188
101510015165	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
101510015166	putative active site [active]
101510015167	metal binding site [ion binding]; metal-binding site
101510015168	Histidine kinase; Region: HisKA_3; pfam07730
101510015169	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
101510015170	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
101510015171	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510015172	active site
101510015173	phosphorylation site [posttranslational modification]
101510015174	intermolecular recognition site; other site
101510015175	dimerization interface [polypeptide binding]; other site
101510015176	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510015177	DNA binding residues [nucleotide binding]
101510015178	dimerization interface [polypeptide binding]; other site
101510015179	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
101510015180	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
101510015181	Walker A/P-loop; other site
101510015182	ATP binding site [chemical binding]; other site
101510015183	Q-loop/lid; other site
101510015184	ABC transporter signature motif; other site
101510015185	Walker B; other site
101510015186	D-loop; other site
101510015187	H-loop/switch region; other site
101510015188	ABC-2 type transporter; Region: ABC2_membrane; cl11417
101510015189	ABC-2 type transporter; Region: ABC2_membrane; cl11417
101510015190	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
101510015191	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
101510015192	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510015193	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
101510015194	Helix-turn-helix domains; Region: HTH; cl00088
101510015195	mycofactocin system RPExFGAL protein; Region: Ac_RPExFGAL; TIGR03967
101510015196	mycofactocin radical SAM maturase; Region: rSAM_MSMEG_1423; TIGR03962
101510015197	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
101510015198	FeS/SAM binding site; other site
101510015199	radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; cl14869
101510015200	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
101510015201	heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966
101510015202	phosphate binding site [ion binding]; other site
101510015203	mycofactocin system FadH/OYE family oxidoreductase 1; Region: mycofact_OYE_1; TIGR03996
101510015204	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
101510015205	phosphate binding site [ion binding]; other site
101510015206	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
101510015207	classical (c) SDRs; Region: SDR_c; cd05233
101510015208	NAD(P) binding site [chemical binding]; other site
101510015209	active site
101510015210	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
101510015211	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
101510015212	phosphate binding site [ion binding]; other site
101510015213	Creatinine amidohydrolase; Region: Creatininase; cl00618
101510015214	mycofactocin system glycosyltransferase; Region: actino_glycTran; TIGR03965
101510015215	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
101510015216	Probable Catalytic site; other site
101510015217	metal-binding site
101510015218	dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970
101510015219	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
101510015220	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
101510015221	Helix-turn-helix domains; Region: HTH; cl00088
101510015222	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
101510015223	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510015224	NAD(P) binding site [chemical binding]; other site
101510015225	catalytic residues [active]
101510015226	Protein of unknown function (DUF779); Region: DUF779; cl01432
101510015227	ethanolamine permease; Region: 2A0305; TIGR00908
101510015228	Amino acid permease; Region: AA_permease; cl00524
101510015229	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
101510015230	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
101510015231	Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762
101510015232	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510015233	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510015234	putative substrate translocation pore; other site
101510015235	AMP-binding domain protein; Validated; Region: PRK08315
101510015236	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510015237	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
101510015238	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
101510015239	Domain of unknown function (DUF336); Region: DUF336; cl01249
101510015240	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
101510015241	Histidine kinase; Region: HisKA_3; pfam07730
101510015242	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510015243	ATP binding site [chemical binding]; other site
101510015244	Mg2+ binding site [ion binding]; other site
101510015245	G-X-G motif; other site
101510015246	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
101510015247	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510015248	active site
101510015249	phosphorylation site [posttranslational modification]
101510015250	intermolecular recognition site; other site
101510015251	dimerization interface [polypeptide binding]; other site
101510015252	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510015253	DNA binding residues [nucleotide binding]
101510015254	dimerization interface [polypeptide binding]; other site
101510015255	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
101510015256	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510015257	Helix-turn-helix domains; Region: HTH; cl00088
101510015258	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
101510015259	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780
101510015260	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
101510015261	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
101510015262	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
101510015263	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
101510015264	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
101510015265	carboxyltransferase (CT) interaction site; other site
101510015266	biotinylation site [posttranslational modification]; other site
101510015267	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510015268	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510015269	active site
101510015270	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
101510015271	putative active site [active]
101510015272	putative catalytic site [active]
101510015273	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
101510015274	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
101510015275	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
101510015276	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510015277	peptide synthase; Provisional; Region: PRK12316
101510015278	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510015279	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510015280	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
101510015281	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510015282	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510015283	peptide synthase; Provisional; Region: PRK12467
101510015284	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510015285	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510015286	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510015287	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510015288	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
101510015289	peptide synthase; Provisional; Region: PRK12467
101510015290	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510015291	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510015292	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510015293	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510015294	peptide synthase; Provisional; Region: PRK12467
101510015295	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510015296	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510015297	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510015298	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510015299	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
101510015300	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510015301	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510015302	Condensation domain; Region: Condensation; pfam00668
101510015303	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
101510015304	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
101510015305	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510015306	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
101510015307	NAD(P) binding pocket [chemical binding]; other site
101510015308	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
101510015309	Glutamine amidotransferase class-I; Region: GATase; pfam00117
101510015310	glutamine binding [chemical binding]; other site
101510015311	catalytic triad [active]
101510015312	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
101510015313	chorismate binding enzyme; Region: Chorismate_bind; cl10555
101510015314	Chorismate mutase type II; Region: CM_2; cl00693
101510015315	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510015316	Transcriptional regulators [Transcription]; Region: GntR; COG1802
101510015317	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510015318	DNA-binding site [nucleotide binding]; DNA binding site
101510015319	FCD domain; Region: FCD; cl11656
101510015320	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510015321	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510015322	active site
101510015323	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510015324	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
101510015325	NAD(P) binding site [chemical binding]; other site
101510015326	catalytic residues [active]
101510015327	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
101510015328	Helix-turn-helix domains; Region: HTH; cl00088
101510015329	Helix-turn-helix domains; Region: HTH; cl00088
101510015330	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
101510015331	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
101510015332	dimer interface [polypeptide binding]; other site
101510015333	active site
101510015334	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
101510015335	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510015336	substrate binding site [chemical binding]; other site
101510015337	oxyanion hole (OAH) forming residues; other site
101510015338	trimer interface [polypeptide binding]; other site
101510015339	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510015340	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
101510015341	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
101510015342	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
101510015343	FMN binding site [chemical binding]; other site
101510015344	substrate binding site [chemical binding]; other site
101510015345	putative catalytic residue [active]
101510015346	enoyl-CoA hydratase; Provisional; Region: PRK06688
101510015347	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510015348	substrate binding site [chemical binding]; other site
101510015349	oxyanion hole (OAH) forming residues; other site
101510015350	trimer interface [polypeptide binding]; other site
101510015351	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786
101510015352	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510015353	Domain of unknown function DUF140; Region: DUF140; cl00510
101510015354	Domain of unknown function DUF140; Region: DUF140; cl00510
101510015355	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
101510015356	mce related protein; Region: MCE; cl15431
101510015357	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
101510015358	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
101510015359	mce related protein; Region: MCE; cl15431
101510015360	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
101510015361	mce related protein; Region: MCE; cl15431
101510015362	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
101510015363	mce related protein; Region: MCE; cl15431
101510015364	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
101510015365	mce related protein; Region: MCE; cl15431
101510015366	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
101510015367	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
101510015368	mce related protein; Region: MCE; cl15431
101510015369	ABC-2 type transporter; Region: ABC2_membrane; cl11417
101510015370	ABC-2 type transporter; Region: ABC2_membrane; cl11417
101510015371	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510015372	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
101510015373	Walker A/P-loop; other site
101510015374	ATP binding site [chemical binding]; other site
101510015375	Q-loop/lid; other site
101510015376	ABC transporter signature motif; other site
101510015377	Walker B; other site
101510015378	D-loop; other site
101510015379	H-loop/switch region; other site
101510015380	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
101510015381	CoenzymeA binding site [chemical binding]; other site
101510015382	subunit interaction site [polypeptide binding]; other site
101510015383	PHB binding site; other site
101510015384	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
101510015385	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
101510015386	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
101510015387	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
101510015388	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
101510015389	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
101510015390	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
101510015391	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
101510015392	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
101510015393	putative translocon binding site; other site
101510015394	protein-rRNA interface [nucleotide binding]; other site
101510015395	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
101510015396	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
101510015397	G-X-X-G motif; other site
101510015398	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
101510015399	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
101510015400	23S rRNA interface [nucleotide binding]; other site
101510015401	5S rRNA interface [nucleotide binding]; other site
101510015402	putative antibiotic binding site [chemical binding]; other site
101510015403	L25 interface [polypeptide binding]; other site
101510015404	L27 interface [polypeptide binding]; other site
101510015405	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
101510015406	putative translocon interaction site; other site
101510015407	signal recognition particle (SRP54) interaction site; other site
101510015408	L23 interface [polypeptide binding]; other site
101510015409	trigger factor interaction site; other site
101510015410	23S rRNA interface [nucleotide binding]; other site
101510015411	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
101510015412	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
101510015413	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
101510015414	KOW motif; Region: KOW; cl00354
101510015415	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
101510015416	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
101510015417	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
101510015418	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
101510015419	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
101510015420	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
101510015421	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
101510015422	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
101510015423	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
101510015424	5S rRNA interface [nucleotide binding]; other site
101510015425	L27 interface [polypeptide binding]; other site
101510015426	23S rRNA interface [nucleotide binding]; other site
101510015427	L5 interface [polypeptide binding]; other site
101510015428	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
101510015429	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
101510015430	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
101510015431	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
101510015432	23S rRNA binding site [nucleotide binding]; other site
101510015433	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
101510015434	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
101510015435	SecY translocase; Region: SecY; pfam00344
101510015436	adenylate kinase; Reviewed; Region: adk; PRK00279
101510015437	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
101510015438	AMP-binding site [chemical binding]; other site
101510015439	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
101510015440	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
101510015441	active site
101510015442	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
101510015443	putative active site [active]
101510015444	dimerization interface [polypeptide binding]; other site
101510015445	putative tRNAtyr binding site [nucleotide binding]; other site
101510015446	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
101510015447	rRNA binding site [nucleotide binding]; other site
101510015448	predicted 30S ribosome binding site; other site
101510015449	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
101510015450	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
101510015451	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
101510015452	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
101510015453	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
101510015454	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
101510015455	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
101510015456	RNA binding surface [nucleotide binding]; other site
101510015457	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
101510015458	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
101510015459	alphaNTD - beta interaction site [polypeptide binding]; other site
101510015460	alphaNTD homodimer interface [polypeptide binding]; other site
101510015461	alphaNTD - beta' interaction site [polypeptide binding]; other site
101510015462	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
101510015463	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
101510015464	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
101510015465	PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570
101510015466	dimerization interface 3.5A [polypeptide binding]; other site
101510015467	active site
101510015468	Protein of unknown function (DUF2984); Region: DUF2984; cl12752
101510015469	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
101510015470	Helix-turn-helix domains; Region: HTH; cl00088
101510015471	Amidinotransferase; Region: Amidinotransf; cl12043
101510015472	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
101510015473	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
101510015474	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
101510015475	inhibitor-cofactor binding pocket; inhibition site
101510015476	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510015477	catalytic residue [active]
101510015478	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
101510015479	23S rRNA interface [nucleotide binding]; other site
101510015480	L3 interface [polypeptide binding]; other site
101510015481	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
101510015482	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
101510015483	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
101510015484	active site
101510015485	substrate binding site [chemical binding]; other site
101510015486	metal binding site [ion binding]; metal-binding site
101510015487	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
101510015488	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
101510015489	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
101510015490	glutaminase active site [active]
101510015491	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
101510015492	dimer interface [polypeptide binding]; other site
101510015493	active site
101510015494	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
101510015495	dimer interface [polypeptide binding]; other site
101510015496	active site
101510015497	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
101510015498	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
101510015499	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
101510015500	putative substrate binding site [chemical binding]; other site
101510015501	putative ATP binding site [chemical binding]; other site
101510015502	alanine racemase; Reviewed; Region: alr; PRK00053
101510015503	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
101510015504	active site
101510015505	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
101510015506	dimer interface [polypeptide binding]; other site
101510015507	substrate binding site [chemical binding]; other site
101510015508	catalytic residues [active]
101510015509	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510015510	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510015511	Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520
101510015512	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
101510015513	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
101510015514	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
101510015515	Coenzyme A binding pocket [chemical binding]; other site
101510015516	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
101510015517	UGMP family protein; Validated; Region: PRK09604
101510015518	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
101510015519	Ion channel; Region: Ion_trans_2; cl11596
101510015520	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
101510015521	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
101510015522	oligomerisation interface [polypeptide binding]; other site
101510015523	mobile loop; other site
101510015524	roof hairpin; other site
101510015525	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
101510015526	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
101510015527	ring oligomerisation interface [polypeptide binding]; other site
101510015528	ATP/Mg binding site [chemical binding]; other site
101510015529	stacking interactions; other site
101510015530	hinge regions; other site
101510015531	Anti-sigma-K factor rskA; Region: RskA; cl15366
101510015532	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
101510015533	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
101510015534	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
101510015535	DNA binding residues [nucleotide binding]
101510015536	Transcription factor WhiB; Region: Whib; pfam02467
101510015537	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
101510015538	DNA binding residues [nucleotide binding]
101510015539	RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648
101510015540	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
101510015541	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
101510015542	DNA binding residues [nucleotide binding]
101510015543	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
101510015544	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
101510015545	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601
101510015546	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
101510015547	active site
101510015548	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
101510015549	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
101510015550	phosphate binding site [ion binding]; other site
101510015551	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
101510015552	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510015553	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510015554	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
101510015555	GMP synthase; Reviewed; Region: guaA; PRK00074
101510015556	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
101510015557	AMP/PPi binding site [chemical binding]; other site
101510015558	candidate oxyanion hole; other site
101510015559	catalytic triad [active]
101510015560	potential glutamine specificity residues [chemical binding]; other site
101510015561	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
101510015562	ATP Binding subdomain [chemical binding]; other site
101510015563	Ligand Binding sites [chemical binding]; other site
101510015564	Dimerization subdomain; other site
101510015565	PspC domain; Region: PspC; cl00864
101510015566	Predicted membrane protein (DUF2154); Region: DUF2154; cl12089
101510015567	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
101510015568	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510015569	ATP binding site [chemical binding]; other site
101510015570	Mg2+ binding site [ion binding]; other site
101510015571	G-X-G motif; other site
101510015572	Proteins of 100 residues with WXG; Region: WXG100; cl02005
101510015573	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
101510015574	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510015575	active site
101510015576	phosphorylation site [posttranslational modification]
101510015577	intermolecular recognition site; other site
101510015578	dimerization interface [polypeptide binding]; other site
101510015579	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510015580	DNA binding residues [nucleotide binding]
101510015581	dimerization interface [polypeptide binding]; other site
101510015582	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510015583	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510015584	active site
101510015585	ATP binding site [chemical binding]; other site
101510015586	substrate binding site [chemical binding]; other site
101510015587	activation loop (A-loop); other site
101510015588	DNA Polymerase Y-family; Region: PolY_like; cd03468
101510015589	active site
101510015590	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
101510015591	DNA binding site [nucleotide binding]
101510015592	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
101510015593	ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351
101510015594	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510015595	metal binding site [ion binding]; metal-binding site
101510015596	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883
101510015597	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510015598	Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911
101510015599	active site
101510015600	diiron metal binding site [ion binding]; other site
101510015601	Protein of unknown function (DUF419); Region: DUF419; cl15265
101510015602	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
101510015603	putative dimer interface [polypeptide binding]; other site
101510015604	putative [2Fe-2S] cluster binding site [ion binding]; other site
101510015605	short chain dehydrogenase; Provisional; Region: PRK07201
101510015606	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
101510015607	putative NAD(P) binding site [chemical binding]; other site
101510015608	active site
101510015609	putative substrate binding site [chemical binding]; other site
101510015610	classical (c) SDRs; Region: SDR_c; cd05233
101510015611	NAD(P) binding site [chemical binding]; other site
101510015612	active site
101510015613	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
101510015614	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
101510015615	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
101510015616	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
101510015617	putative ligand binding residues [chemical binding]; other site
101510015618	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
101510015619	dimer interface [polypeptide binding]; other site
101510015620	putative PBP binding regions; other site
101510015621	ABC-ATPase subunit  interface; other site
101510015622	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
101510015623	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
101510015624	Walker A/P-loop; other site
101510015625	ATP binding site [chemical binding]; other site
101510015626	Q-loop/lid; other site
101510015627	ABC transporter signature motif; other site
101510015628	Walker B; other site
101510015629	D-loop; other site
101510015630	H-loop/switch region; other site
101510015631	siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951
101510015632	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
101510015633	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
101510015634	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
101510015635	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
101510015636	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
101510015637	generic binding surface II; other site
101510015638	generic binding surface I; other site
101510015639	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
101510015640	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
101510015641	active site residue [active]
101510015642	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320
101510015643	gating phenylalanine in ion channel; other site
101510015644	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
101510015645	Helix-turn-helix domains; Region: HTH; cl00088
101510015646	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
101510015647	putative dimerization interface [polypeptide binding]; other site
101510015648	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
101510015649	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
101510015650	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
101510015651	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
101510015652	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
101510015653	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
101510015654	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
101510015655	homodimer interface [polypeptide binding]; other site
101510015656	NADP binding site [chemical binding]; other site
101510015657	substrate binding site [chemical binding]; other site
101510015658	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
101510015659	homoserine O-acetyltransferase; Provisional; Region: metX; cl15472
101510015660	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
101510015661	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812
101510015662	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
101510015663	homodimer interface [polypeptide binding]; other site
101510015664	substrate-cofactor binding pocket; other site
101510015665	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510015666	catalytic residue [active]
101510015667	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
101510015668	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510015669	Major Facilitator Superfamily; Region: MFS_1; pfam07690
101510015670	putative substrate translocation pore; other site
101510015671	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
101510015672	putative active site [active]
101510015673	putative DNA binding site [nucleotide binding]; other site
101510015674	putative phosphate binding site [ion binding]; other site
101510015675	putative catalytic site [active]
101510015676	metal binding site A [ion binding]; metal-binding site
101510015677	putative AP binding site [nucleotide binding]; other site
101510015678	putative metal binding site B [ion binding]; other site
101510015679	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
101510015680	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
101510015681	active site
101510015682	HIGH motif; other site
101510015683	dimer interface [polypeptide binding]; other site
101510015684	KMSKS motif; other site
101510015685	Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918
101510015686	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
101510015687	malate dehydrogenase; Provisional; Region: PRK05442
101510015688	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
101510015689	NAD(P) binding site [chemical binding]; other site
101510015690	dimer interface [polypeptide binding]; other site
101510015691	malate binding site [chemical binding]; other site
101510015692	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
101510015693	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
101510015694	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510015695	domain; Region: Succ_DH_flav_C; pfam02910
101510015696	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500
101510015697	putative Iron-sulfur protein interface [polypeptide binding]; other site
101510015698	putative proximal heme binding site [chemical binding]; other site
101510015699	putative SdhC-like subunit interface [polypeptide binding]; other site
101510015700	putative distal heme binding site [chemical binding]; other site
101510015701	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501
101510015702	putative Iron-sulfur protein interface [polypeptide binding]; other site
101510015703	putative proximal heme binding site [chemical binding]; other site
101510015704	putative SdhD-like interface [polypeptide binding]; other site
101510015705	putative distal heme binding site [chemical binding]; other site
101510015706	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
101510015707	active site
101510015708	catalytic motif [active]
101510015709	Zn binding site [ion binding]; other site
101510015710	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
101510015711	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
101510015712	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
101510015713	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734
101510015714	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
101510015715	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
101510015716	active site
101510015717	Peptidase family M23; Region: Peptidase_M23; pfam01551
101510015718	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
101510015719	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
101510015720	Probable transposase; Region: OrfB_IS605; pfam01385
101510015721	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
101510015722	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
101510015723	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
101510015724	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
101510015725	active site
101510015726	substrate binding site [chemical binding]; other site
101510015727	metal binding site [ion binding]; metal-binding site
101510015728	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
101510015729	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510015730	substrate binding site [chemical binding]; other site
101510015731	oxyanion hole (OAH) forming residues; other site
101510015732	trimer interface [polypeptide binding]; other site
101510015733	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
101510015734	amidohydrolase; Region: amidohydrolases; TIGR01891
101510015735	metal binding site [ion binding]; metal-binding site
101510015736	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
101510015737	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
101510015738	metal binding site [ion binding]; metal-binding site
101510015739	putative dimer interface [polypeptide binding]; other site
101510015740	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
101510015741	putative active site pocket [active]
101510015742	dimerization interface [polypeptide binding]; other site
101510015743	putative catalytic residue [active]
101510015744	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
101510015745	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510015746	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510015747	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
101510015748	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
101510015749	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
101510015750	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510015751	homodimer interface [polypeptide binding]; other site
101510015752	catalytic residue [active]
101510015753	glycerol kinase; Provisional; Region: glpK; PRK00047
101510015754	Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789
101510015755	N- and C-terminal domain interface [polypeptide binding]; other site
101510015756	putative active site [active]
101510015757	putative MgATP binding site [chemical binding]; other site
101510015758	catalytic site [active]
101510015759	metal binding site [ion binding]; metal-binding site
101510015760	putative homotetramer interface [polypeptide binding]; other site
101510015761	putative glycerol binding site [chemical binding]; other site
101510015762	homodimer interface [polypeptide binding]; other site
101510015763	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
101510015764	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510015765	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
101510015766	Protein of unknown function (DUF1353); Region: DUF1353; pfam07087
101510015767	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
101510015768	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
101510015769	putative DNA binding site [nucleotide binding]; other site
101510015770	catalytic residue [active]
101510015771	putative H2TH interface [polypeptide binding]; other site
101510015772	putative catalytic residues [active]
101510015773	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
101510015774	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
101510015775	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
101510015776	ATP binding site [chemical binding]; other site
101510015777	putative Mg++ binding site [ion binding]; other site
101510015778	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
101510015779	nucleotide binding region [chemical binding]; other site
101510015780	ATP-binding site [chemical binding]; other site
101510015781	DEAD/H associated; Region: DEAD_assoc; pfam08494
101510015782	Domain of unknown function DUF222; Region: DUF222; pfam02720
101510015783	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510015784	active site
101510015785	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
101510015786	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510015787	tetrameric interface [polypeptide binding]; other site
101510015788	NAD binding site [chemical binding]; other site
101510015789	catalytic residues [active]
101510015790	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
101510015791	Helix-turn-helix domains; Region: HTH; cl00088
101510015792	L-lysine aminotransferase; Provisional; Region: PRK08297
101510015793	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
101510015794	inhibitor-cofactor binding pocket; inhibition site
101510015795	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510015796	catalytic residue [active]
101510015797	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
101510015798	VanZ like family; Region: VanZ; cl01971
101510015799	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
101510015800	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
101510015801	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
101510015802	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
101510015803	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
101510015804	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
101510015805	carboxyltransferase (CT) interaction site; other site
101510015806	biotinylation site [posttranslational modification]; other site
101510015807	Condensation domain; Region: Condensation; pfam00668
101510015808	Fe-S metabolism associated domain; Region: SufE; cl00951
101510015809	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
101510015810	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
101510015811	active site residue [active]
101510015812	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
101510015813	active site residue [active]
101510015814	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
101510015815	heme-binding site [chemical binding]; other site
101510015816	Condensation domain; Region: Condensation; pfam00668
101510015817	peptide synthase; Provisional; Region: PRK12316
101510015818	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510015819	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
101510015820	putative substrate translocation pore; other site
101510015821	Maf-like protein; Region: Maf; pfam02545
101510015822	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
101510015823	active site
101510015824	dimer interface [polypeptide binding]; other site
101510015825	Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822
101510015826	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
101510015827	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780
101510015828	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780
101510015829	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
101510015830	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
101510015831	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
101510015832	Uncharacterized conserved protein [Function unknown]; Region: HdeD; cl01277
101510015833	Bacterial membrane flanked domain; Region: DUF304; cl01348
101510015834	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
101510015835	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510015836	active site
101510015837	phosphorylation site [posttranslational modification]
101510015838	intermolecular recognition site; other site
101510015839	dimerization interface [polypeptide binding]; other site
101510015840	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
101510015841	DNA binding site [nucleotide binding]
101510015842	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
101510015843	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
101510015844	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510015845	ATP binding site [chemical binding]; other site
101510015846	Mg2+ binding site [ion binding]; other site
101510015847	G-X-G motif; other site
101510015848	GtrA-like protein; Region: GtrA; cl00971
101510015849	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
101510015850	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
101510015851	AIR carboxylase; Region: AIRC; cl00310
101510015852	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
101510015853	putative active site [active]
101510015854	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510015855	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
101510015856	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
101510015857	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
101510015858	NADP binding site [chemical binding]; other site
101510015859	putative substrate binding site [chemical binding]; other site
101510015860	active site
101510015861	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
101510015862	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
101510015863	Probable Catalytic site; other site
101510015864	metal-binding site
101510015865	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
101510015866	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
101510015867	active site
101510015868	Substrate binding site; other site
101510015869	Mg++ binding site; other site
101510015870	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
101510015871	N-terminal domain interface [polypeptide binding]; other site
101510015872	sulfate 1 binding site; other site
101510015873	Transposase IS200 like; Region: Y1_Tnp; cl00848
101510015874	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
101510015875	nudix motif; other site
101510015876	F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294
101510015877	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
101510015878	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
101510015879	putative FMN binding site [chemical binding]; other site
101510015880	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cl00425
101510015881	dimer interface [polypeptide binding]; other site
101510015882	phosphate binding site [ion binding]; other site
101510015883	Transcription factor WhiB; Region: Whib; pfam02467
101510015884	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
101510015885	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
101510015886	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
101510015887	active site
101510015888	substrate binding site [chemical binding]; other site
101510015889	metal binding site [ion binding]; metal-binding site
101510015890	bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674
101510015891	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
101510015892	Phosphomannose isomerase type I; Region: PMI_typeI; cl15429
101510015893	Cation efflux family; Region: Cation_efflux; cl00316
101510015894	Amino acid permease; Region: AA_permease; cl00524
101510015895	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510015896	Helix-turn-helix domains; Region: HTH; cl00088
101510015897	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
101510015898	S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401
101510015899	oligomerization interface [polypeptide binding]; other site
101510015900	active site
101510015901	NAD+ binding site [chemical binding]; other site
101510015902	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
101510015903	Thymidylate kinase; Region: Thymidylate_kin; pfam02223
101510015904	TMP-binding site; other site
101510015905	ATP-binding site [chemical binding]; other site
101510015906	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
101510015907	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510015908	active site
101510015909	phosphorylation site [posttranslational modification]
101510015910	intermolecular recognition site; other site
101510015911	dimerization interface [polypeptide binding]; other site
101510015912	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
101510015913	DNA binding site [nucleotide binding]
101510015914	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
101510015915	dimerization interface [polypeptide binding]; other site
101510015916	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
101510015917	dimer interface [polypeptide binding]; other site
101510015918	phosphorylation site [posttranslational modification]
101510015919	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510015920	ATP binding site [chemical binding]; other site
101510015921	Mg2+ binding site [ion binding]; other site
101510015922	G-X-G motif; other site
101510015923	lipoprotein LpqB; Provisional; Region: PRK13616
101510015924	Sporulation and spore germination; Region: Germane; cl11253
101510015925	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
101510015926	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552
101510015927	30S subunit binding site; other site
101510015928	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
101510015929	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510015930	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
101510015931	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
101510015932	nucleotide binding region [chemical binding]; other site
101510015933	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
101510015934	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
101510015935	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
101510015936	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
101510015937	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
101510015938	FAD binding pocket [chemical binding]; other site
101510015939	FAD binding motif [chemical binding]; other site
101510015940	phosphate binding motif [ion binding]; other site
101510015941	beta-alpha-beta structure motif; other site
101510015942	NAD binding pocket [chemical binding]; other site
101510015943	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510015944	catalytic loop [active]
101510015945	iron binding site [ion binding]; other site
101510015946	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
101510015947	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
101510015948	putative di-iron ligands [ion binding]; other site
101510015949	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
101510015950	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
101510015951	putative di-iron ligands [ion binding]; other site
101510015952	Predicted GTPases [General function prediction only]; Region: COG1162
101510015953	YjeQ/EngC.  YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs...; Region: YjeQ_engC; cd01854
101510015954	GTPase/OB domain interface [polypeptide binding]; other site
101510015955	GTPase/Zn-binding domain interface [polypeptide binding]; other site
101510015956	GTP/Mg2+ binding site [chemical binding]; other site
101510015957	G4 box; other site
101510015958	G5 box; other site
101510015959	G1 box; other site
101510015960	Switch I region; other site
101510015961	G2 box; other site
101510015962	G3 box; other site
101510015963	Switch II region; other site
101510015964	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
101510015965	3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356
101510015966	hinge; other site
101510015967	active site
101510015968	Uncharacterised ACR, COG2135; Region: DUF159; cl03646
101510015969	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
101510015970	putative deacylase active site [active]
101510015971	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
101510015972	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
101510015973	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
101510015974	DNA binding residues [nucleotide binding]
101510015975	Anti-sigma-K factor rskA; Region: RskA; cl15366
101510015976	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
101510015977	carboxyltransferase (CT) interaction site; other site
101510015978	biotinylation site [posttranslational modification]; other site
101510015979	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
101510015980	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
101510015981	Histidine kinase; Region: HisKA_2; cl06527
101510015982	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510015983	ATP binding site [chemical binding]; other site
101510015984	Mg2+ binding site [ion binding]; other site
101510015985	G-X-G motif; other site
101510015986	Transcription factor WhiB; Region: Whib; pfam02467
101510015987	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
101510015988	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
101510015989	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
101510015990	Coenzyme A binding pocket [chemical binding]; other site
101510015991	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
101510015992	catalytic core [active]
101510015993	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
101510015994	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
101510015995	P-loop; other site
101510015996	Magnesium ion binding site [ion binding]; other site
101510015997	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
101510015998	Magnesium ion binding site [ion binding]; other site
101510015999	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510016000	3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428
101510016001	NAD(P) binding site [chemical binding]; other site
101510016002	active site
101510016003	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
101510016004	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
101510016005	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
101510016006	conserved cys residue [active]
101510016007	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510016008	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510016009	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510016010	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
101510016011	active site
101510016012	metal binding site [ion binding]; metal-binding site
101510016013	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
101510016014	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
101510016015	ATP binding site [chemical binding]; other site
101510016016	Mg++ binding site [ion binding]; other site
101510016017	motif III; other site
101510016018	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
101510016019	nucleotide binding region [chemical binding]; other site
101510016020	ATP-binding site [chemical binding]; other site
101510016021	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
101510016022	dinuclear metal binding motif [ion binding]; other site
101510016023	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
101510016024	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510016025	Helix-turn-helix domains; Region: HTH; cl00088
101510016026	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
101510016027	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
101510016028	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
101510016029	ATP binding site [chemical binding]; other site
101510016030	substrate interface [chemical binding]; other site
101510016031	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
101510016032	active site residue [active]
101510016033	TIGR02569 family protein; Region: TIGR02569_actnb
101510016034	Transcriptional regulators [Transcription]; Region: FadR; COG2186
101510016035	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510016036	DNA-binding site [nucleotide binding]; DNA binding site
101510016037	FCD domain; Region: FCD; cl11656
101510016038	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
101510016039	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510016040	putative substrate translocation pore; other site
101510016041	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
101510016042	nitrite reductase subunit NirD; Provisional; Region: PRK14989
101510016043	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510016044	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
101510016045	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
101510016046	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
101510016047	bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239
101510016048	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
101510016049	active site
101510016050	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
101510016051	DNA binding site [nucleotide binding]
101510016052	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
101510016053	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
101510016054	putative active site [active]
101510016055	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
101510016056	putative active site [active]
101510016057	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
101510016058	active site
101510016059	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
101510016060	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
101510016061	MPT binding site; other site
101510016062	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
101510016063	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510016064	DNA-binding site [nucleotide binding]; DNA binding site
101510016065	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
101510016066	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510016067	homodimer interface [polypeptide binding]; other site
101510016068	catalytic residue [active]
101510016069	Secretory lipase; Region: LIP; pfam03583
101510016070	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
101510016071	active site
101510016072	DNA binding site [nucleotide binding]
101510016073	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510016074	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510016075	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510016076	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
101510016077	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
101510016078	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
101510016079	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510016080	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
101510016081	Predicted membrane protein [Function unknown]; Region: COG4270
101510016082	Ion channel; Region: Ion_trans_2; cl11596
101510016083	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
101510016084	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510016085	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
101510016086	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
101510016087	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
101510016088	putative NADH binding site [chemical binding]; other site
101510016089	putative active site [active]
101510016090	nudix motif; other site
101510016091	putative metal binding site [ion binding]; other site
101510016092	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
101510016093	catalytic residues [active]
101510016094	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510016095	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
101510016096	HRDC domain; Region: HRDC; cl02578
101510016097	Transcription factor WhiB; Region: Whib; pfam02467
101510016098	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
101510016099	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691
101510016100	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
101510016101	active site
101510016102	ATP binding site [chemical binding]; other site
101510016103	Uncharacterised conserved protein (DUF2342); Region: DUF2342; cl02183
101510016104	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
101510016105	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
101510016106	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
101510016107	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
101510016108	Uncharacterised protein family (UPF0182); Region: UPF0182; pfam03699
101510016109	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
101510016110	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
101510016111	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510016112	DNA-binding site [nucleotide binding]; DNA binding site
101510016113	FCD domain; Region: FCD; cl11656
101510016114	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
101510016115	flavanone-3-hydroxylase; Provisional; Region: PLN03176
101510016116	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206
101510016117	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510016118	dimer interface [polypeptide binding]; other site
101510016119	conserved gate region; other site
101510016120	putative PBP binding loops; other site
101510016121	ABC-ATPase subunit interface; other site
101510016122	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
101510016123	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
101510016124	Walker A/P-loop; other site
101510016125	ATP binding site [chemical binding]; other site
101510016126	Q-loop/lid; other site
101510016127	ABC transporter signature motif; other site
101510016128	Walker B; other site
101510016129	D-loop; other site
101510016130	H-loop/switch region; other site
101510016131	acyl-CoA synthetase; Validated; Region: PRK07788
101510016132	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510016133	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510016134	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510016135	active site
101510016136	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510016137	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510016138	active site
101510016139	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
101510016140	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
101510016141	active site
101510016142	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
101510016143	active site clefts [active]
101510016144	zinc binding site [ion binding]; other site
101510016145	dimer interface [polypeptide binding]; other site
101510016146	peptide chain release factor 2; Validated; Region: prfB; PRK00578
101510016147	RF-1 domain; Region: RF-1; cl02875
101510016148	RF-1 domain; Region: RF-1; cl02875
101510016149	Mechanosensitive ion channel; Region: MS_channel; pfam00924
101510016150	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
101510016151	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510016152	Walker A/P-loop; other site
101510016153	ATP binding site [chemical binding]; other site
101510016154	Q-loop/lid; other site
101510016155	ABC transporter signature motif; other site
101510016156	Walker B; other site
101510016157	D-loop; other site
101510016158	H-loop/switch region; other site
101510016159	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
101510016160	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
101510016161	SmpB-tmRNA interface; other site
101510016162	CrcB-like protein; Region: CRCB; cl09114
101510016163	phosphoglucomutase; Validated; Region: PRK07564
101510016164	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
101510016165	active site
101510016166	substrate binding site [chemical binding]; other site
101510016167	metal binding site [ion binding]; metal-binding site
101510016168	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510016169	putative substrate translocation pore; other site
101510016170	Major Facilitator Superfamily; Region: MFS_1; pfam07690
101510016171	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
101510016172	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
101510016173	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
101510016174	PAS fold; Region: PAS_4; pfam08448
101510016175	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
101510016176	putative active site [active]
101510016177	heme pocket [chemical binding]; other site
101510016178	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
101510016179	trimer interface [polypeptide binding]; other site
101510016180	active site
101510016181	substrate binding site [chemical binding]; other site
101510016182	CoA binding site [chemical binding]; other site
101510016183	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510016184	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
101510016185	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510016186	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
101510016187	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
101510016188	putative FMN binding site [chemical binding]; other site
101510016189	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
101510016190	DEAD-like helicases superfamily; Region: DEXDc; smart00487
101510016191	ATP binding site [chemical binding]; other site
101510016192	Mg++ binding site [ion binding]; other site
101510016193	motif III; other site
101510016194	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
101510016195	nucleotide binding region [chemical binding]; other site
101510016196	ATP-binding site [chemical binding]; other site
101510016197	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
101510016198	MoaE homodimer interface [polypeptide binding]; other site
101510016199	MoaD interaction [polypeptide binding]; other site
101510016200	active site residues [active]
101510016201	bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604
101510016202	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
101510016203	trimer interface [polypeptide binding]; other site
101510016204	dimer interface [polypeptide binding]; other site
101510016205	putative active site [active]
101510016206	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
101510016207	MPT binding site; other site
101510016208	trimer interface [polypeptide binding]; other site
101510016209	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
101510016210	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
101510016211	dimer interface [polypeptide binding]; other site
101510016212	putative functional site; other site
101510016213	putative MPT binding site; other site
101510016214	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
101510016215	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
101510016216	FeS/SAM binding site; other site
101510016217	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
101510016218	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
101510016219	MoaE interaction surface [polypeptide binding]; other site
101510016220	MoeB interaction surface [polypeptide binding]; other site
101510016221	thiocarboxylated glycine; other site
101510016222	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510016223	NAD(P) binding site [chemical binding]; other site
101510016224	active site
101510016225	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
101510016226	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
101510016227	homodimer interface [polypeptide binding]; other site
101510016228	NAD binding pocket [chemical binding]; other site
101510016229	ATP binding pocket [chemical binding]; other site
101510016230	Mg binding site [ion binding]; other site
101510016231	active-site loop [active]
101510016232	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
101510016233	META domain; Region: META; cl01245
101510016234	META domain; Region: META; cl01245
101510016235	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510016236	Helix-turn-helix domains; Region: HTH; cl00088
101510016237	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
101510016238	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
101510016239	FAD binding pocket [chemical binding]; other site
101510016240	FAD binding motif [chemical binding]; other site
101510016241	phosphate binding motif [ion binding]; other site
101510016242	NAD binding pocket [chemical binding]; other site
101510016243	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
101510016244	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
101510016245	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
101510016246	catalytic residues [active]
101510016247	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
101510016248	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
101510016249	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
101510016250	Class I ribonucleotide reductase; Region: RNR_I; cd01679
101510016251	active site
101510016252	dimer interface [polypeptide binding]; other site
101510016253	catalytic residues [active]
101510016254	effector binding site; other site
101510016255	R2 peptide binding site; other site
101510016256	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
101510016257	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
101510016258	dimer interface [polypeptide binding]; other site
101510016259	putative radical transfer pathway; other site
101510016260	diiron center [ion binding]; other site
101510016261	tyrosyl radical; other site
101510016262	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
101510016263	nudix motif; other site
101510016264	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
101510016265	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
101510016266	siderophore binding site; other site
101510016267	iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411
101510016268	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
101510016269	siderophore binding site; other site
101510016270	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
101510016271	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
101510016272	D-pathway; other site
101510016273	Putative ubiquinol binding site [chemical binding]; other site
101510016274	Low-spin heme (heme b) binding site [chemical binding]; other site
101510016275	Putative water exit pathway; other site
101510016276	Binuclear center (heme o3/CuB) [ion binding]; other site
101510016277	K-pathway; other site
101510016278	Putative proton exit pathway; other site
101510016279	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
101510016280	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
101510016281	phosphoserine phosphatase SerB; Region: serB; TIGR00338
101510016282	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
101510016283	motif II; other site
101510016284	Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869
101510016285	dimer interface [polypeptide binding]; other site
101510016286	putative active site [active]
101510016287	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
101510016288	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
101510016289	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
101510016290	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
101510016291	active site
101510016292	catalytic site [active]
101510016293	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
101510016294	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510016295	Walker A/P-loop; other site
101510016296	ATP binding site [chemical binding]; other site
101510016297	Q-loop/lid; other site
101510016298	ABC transporter signature motif; other site
101510016299	Walker B; other site
101510016300	D-loop; other site
101510016301	H-loop/switch region; other site
101510016302	enoyl-CoA hydratase; Provisional; Region: PRK05862
101510016303	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510016304	substrate binding site [chemical binding]; other site
101510016305	oxyanion hole (OAH) forming residues; other site
101510016306	trimer interface [polypeptide binding]; other site
101510016307	tocopherol O-methyltransferase; Region: PLN02244
101510016308	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510016309	S-adenosylmethionine binding site [chemical binding]; other site
101510016310	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
101510016311	Trp docking motif [polypeptide binding]; other site
101510016312	active site
101510016313	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
101510016314	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
101510016315	trimer interface [polypeptide binding]; other site
101510016316	active site
101510016317	substrate binding site [chemical binding]; other site
101510016318	CoA binding site [chemical binding]; other site
101510016319	Protein of unknown function (DUF3253); Region: DUF3253; pfam11625
101510016320	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
101510016321	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
101510016322	Uncharacterized conserved protein [Function unknown]; Region: COG1543
101510016323	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
101510016324	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510016325	S-adenosylmethionine binding site [chemical binding]; other site
101510016326	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
101510016327	Ligand binding site [chemical binding]; other site
101510016328	Electron transfer flavoprotein domain; Region: ETF; pfam01012
101510016329	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
101510016330	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
101510016331	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
101510016332	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
101510016333	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
101510016334	putative acyl-acceptor binding pocket; other site
101510016335	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
101510016336	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
101510016337	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
101510016338	catalytic residue [active]
101510016339	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
101510016340	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
101510016341	CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310
101510016342	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
101510016343	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
101510016344	nucleotide binding pocket [chemical binding]; other site
101510016345	K-X-D-G motif; other site
101510016346	catalytic site [active]
101510016347	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
101510016348	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
101510016349	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
101510016350	Dimer interface [polypeptide binding]; other site
101510016351	BRCT sequence motif; other site
101510016352	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
101510016353	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
101510016354	Coenzyme A binding pocket [chemical binding]; other site
101510016355	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
101510016356	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
101510016357	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
101510016358	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
101510016359	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
101510016360	Predicted membrane protein (DUF2319); Region: DUF2319; cl15412
101510016361	Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056
101510016362	Histidine kinase; Region: HisKA_3; pfam07730
101510016363	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
101510016364	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
101510016365	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510016366	active site
101510016367	phosphorylation site [posttranslational modification]
101510016368	intermolecular recognition site; other site
101510016369	dimerization interface [polypeptide binding]; other site
101510016370	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510016371	DNA binding residues [nucleotide binding]
101510016372	dimerization interface [polypeptide binding]; other site
101510016373	6-phosphofructokinase; Provisional; Region: PRK03202
101510016374	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
101510016375	active site
101510016376	ADP/pyrophosphate binding site [chemical binding]; other site
101510016377	dimerization interface [polypeptide binding]; other site
101510016378	allosteric effector site; other site
101510016379	fructose-1,6-bisphosphate binding site; other site
101510016380	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
101510016381	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
101510016382	GatB domain; Region: GatB_Yqey; cl11497
101510016383	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
101510016384	DoxX; Region: DoxX; cl00976
101510016385	Amino acid permease; Region: AA_permease; cl00524
101510016386	Dehydratase family; Region: ILVD_EDD; cl00340
101510016387	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
101510016388	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
101510016389	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
101510016390	PYR/PP interface [polypeptide binding]; other site
101510016391	dimer interface [polypeptide binding]; other site
101510016392	TPP binding site [chemical binding]; other site
101510016393	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
101510016394	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
101510016395	TPP-binding site [chemical binding]; other site
101510016396	dimer interface [polypeptide binding]; other site
101510016397	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
101510016398	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
101510016399	putative valine binding site [chemical binding]; other site
101510016400	dimer interface [polypeptide binding]; other site
101510016401	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
101510016402	ketol-acid reductoisomerase; Provisional; Region: PRK05479
101510016403	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510016404	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
101510016405	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
101510016406	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510016407	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
101510016408	putative L-serine binding site [chemical binding]; other site
101510016409	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
101510016410	tartrate dehydrogenase; Provisional; Region: PRK08194
101510016411	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510016412	putative substrate translocation pore; other site
101510016413	Major Facilitator Superfamily; Region: MFS_1; pfam07690
101510016414	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
101510016415	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
101510016416	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
101510016417	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
101510016418	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
101510016419	HIGH motif; other site
101510016420	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
101510016421	active site
101510016422	KMSKS motif; other site
101510016423	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
101510016424	Helix-turn-helix domains; Region: HTH; cl00088
101510016425	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510016426	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510016427	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
101510016428	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
101510016429	substrate binding site [chemical binding]; other site
101510016430	ligand binding site [chemical binding]; other site
101510016431	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
101510016432	substrate binding site [chemical binding]; other site
101510016433	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
101510016434	IHF - DNA interface [nucleotide binding]; other site
101510016435	IHF dimer interface [polypeptide binding]; other site
101510016436	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
101510016437	active site
101510016438	Ap6A binding site [chemical binding]; other site
101510016439	nudix motif; other site
101510016440	metal binding site [ion binding]; metal-binding site
101510016441	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
101510016442	catalytic core [active]
101510016443	polyphosphate kinase; Provisional; Region: PRK05443
101510016444	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
101510016445	putative domain interface [polypeptide binding]; other site
101510016446	putative active site [active]
101510016447	catalytic site [active]
101510016448	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
101510016449	putative active site [active]
101510016450	catalytic site [active]
101510016451	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
101510016452	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
101510016453	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510016454	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
101510016455	cystathionine gamma-lyase; Validated; Region: PRK07582
101510016456	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
101510016457	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
101510016458	catalytic residue [active]
101510016459	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
101510016460	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
101510016461	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
101510016462	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
101510016463	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
101510016464	thiamine monophosphate kinase; Provisional; Region: PRK05731
101510016465	ATP binding site [chemical binding]; other site
101510016466	dimerization interface [polypeptide binding]; other site
101510016467	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
101510016468	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
101510016469	trimer interface [polypeptide binding]; other site
101510016470	putative metal binding site [ion binding]; other site
101510016471	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
101510016472	ligand binding site [chemical binding]; other site
101510016473	active site
101510016474	UGI interface [polypeptide binding]; other site
101510016475	catalytic site [active]
101510016476	enoyl-CoA hydratase; Provisional; Region: PRK06688
101510016477	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510016478	substrate binding site [chemical binding]; other site
101510016479	oxyanion hole (OAH) forming residues; other site
101510016480	trimer interface [polypeptide binding]; other site
101510016481	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
101510016482	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
101510016483	DAK2 domain; Region: Dak2; cl03685
101510016484	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
101510016485	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
101510016486	generic binding surface II; other site
101510016487	ssDNA binding site; other site
101510016488	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
101510016489	ATP binding site [chemical binding]; other site
101510016490	putative Mg++ binding site [ion binding]; other site
101510016491	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
101510016492	nucleotide binding region [chemical binding]; other site
101510016493	ATP-binding site [chemical binding]; other site
101510016494	pyruvate carboxylase; Reviewed; Region: PRK12999
101510016495	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
101510016496	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
101510016497	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
101510016498	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
101510016499	active site
101510016500	catalytic residues [active]
101510016501	metal binding site [ion binding]; metal-binding site
101510016502	homodimer binding site [polypeptide binding]; other site
101510016503	Conserved carboxylase domain; Region: PYC_OADA; pfam02436
101510016504	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
101510016505	carboxyltransferase (CT) interaction site; other site
101510016506	biotinylation site [posttranslational modification]; other site
101510016507	ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406
101510016508	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510016509	S-adenosylmethionine binding site [chemical binding]; other site
101510016510	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
101510016511	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
101510016512	active site
101510016513	(T/H)XGH motif; other site
101510016514	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
101510016515	Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975
101510016516	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
101510016517	ribonuclease III; Reviewed; Region: rnc; PRK00102
101510016518	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
101510016519	dimerization interface [polypeptide binding]; other site
101510016520	active site
101510016521	metal binding site [ion binding]; metal-binding site
101510016522	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
101510016523	dsRNA binding site [nucleotide binding]; other site
101510016524	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
101510016525	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
101510016526	DNA binding site [nucleotide binding]
101510016527	catalytic residue [active]
101510016528	H2TH interface [polypeptide binding]; other site
101510016529	putative catalytic residues [active]
101510016530	turnover-facilitating residue; other site
101510016531	intercalation triad [nucleotide binding]; other site
101510016532	8OG recognition residue [nucleotide binding]; other site
101510016533	putative reading head residues; other site
101510016534	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
101510016535	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
101510016536	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
101510016537	OsmC-like protein; Region: OsmC; cl00767
101510016538	Acylphosphatase; Region: Acylphosphatase; cl00551
101510016539	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
101510016540	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
101510016541	Walker A/P-loop; other site
101510016542	ATP binding site [chemical binding]; other site
101510016543	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
101510016544	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
101510016545	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
101510016546	ABC transporter signature motif; other site
101510016547	Walker B; other site
101510016548	D-loop; other site
101510016549	H-loop/switch region; other site
101510016550	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
101510016551	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
101510016552	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510016553	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
101510016554	Nitrogen regulatory protein P-II; Region: P-II; cl00412
101510016555	PII uridylyl-transferase; Provisional; Region: PRK03381
101510016556	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
101510016557	metal binding triad; other site
101510016558	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
101510016559	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
101510016560	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
101510016561	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
101510016562	signal recognition particle protein; Provisional; Region: PRK10867
101510016563	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
101510016564	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
101510016565	P loop; other site
101510016566	GTP binding site [chemical binding]; other site
101510016567	Signal peptide binding domain; Region: SRP_SPB; pfam02978
101510016568	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
101510016569	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
101510016570	active site
101510016571	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
101510016572	hypothetical protein; Provisional; Region: PRK00468; cl00794
101510016573	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
101510016574	RimM N-terminal domain; Region: RimM; pfam01782
101510016575	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
101510016576	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
101510016577	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
101510016578	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
101510016579	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
101510016580	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
101510016581	RNA binding site [nucleotide binding]; other site
101510016582	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
101510016583	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
101510016584	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
101510016585	Catalytic site [active]
101510016586	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
101510016587	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
101510016588	RNA/DNA hybrid binding site [nucleotide binding]; other site
101510016589	active site
101510016590	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
101510016591	hypothetical protein; Provisional; Region: PRK10279
101510016592	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
101510016593	active site
101510016594	nucleophile elbow; other site
101510016595	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510016596	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510016597	putative substrate translocation pore; other site
101510016598	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
101510016599	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
101510016600	active site
101510016601	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
101510016602	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
101510016603	Helix-turn-helix domains; Region: HTH; cl00088
101510016604	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
101510016605	Helix-turn-helix domains; Region: HTH; cl00088
101510016606	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510016607	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
101510016608	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510016609	Uncharacterised protein family UPF0102; Region: UPF0102; cl00516
101510016610	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
101510016611	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
101510016612	Walker A motif; other site
101510016613	ATP binding site [chemical binding]; other site
101510016614	Walker B motif; other site
101510016615	arginine finger; other site
101510016616	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
101510016617	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
101510016618	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
101510016619	catalytic residues [active]
101510016620	catalytic nucleophile [active]
101510016621	Recombinase; Region: Recombinase; pfam07508
101510016622	Helix-turn-helix domains; Region: HTH; cl00088
101510016623	DNA-binding site [nucleotide binding]; DNA binding site
101510016624	Phage capsid family; Region: Phage_capsid; pfam05065
101510016625	Phage protein Gp19/Gp15/Gp42; Region: Phage_Gp19; pfam09355
101510016626	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
101510016627	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
101510016628	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
101510016629	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
101510016630	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780
101510016631	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
101510016632	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
101510016633	FAD binding pocket [chemical binding]; other site
101510016634	FAD binding motif [chemical binding]; other site
101510016635	phosphate binding motif [ion binding]; other site
101510016636	NAD binding pocket [chemical binding]; other site
101510016637	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510016638	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
101510016639	putative substrate translocation pore; other site
101510016640	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
101510016641	Peptidase family M23; Region: Peptidase_M23; pfam01551
101510016642	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
101510016643	rRNA interaction site [nucleotide binding]; other site
101510016644	S8 interaction site; other site
101510016645	putative laminin-1 binding site; other site
101510016646	elongation factor Ts; Provisional; Region: tsf; PRK09377
101510016647	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
101510016648	Elongation factor TS; Region: EF_TS; pfam00889
101510016649	Elongation factor TS; Region: EF_TS; pfam00889
101510016650	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
101510016651	putative nucleotide binding site [chemical binding]; other site
101510016652	uridine monophosphate binding site [chemical binding]; other site
101510016653	homohexameric interface [polypeptide binding]; other site
101510016654	ribosome recycling factor; Reviewed; Region: frr; PRK00083
101510016655	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
101510016656	hinge region; other site
101510016657	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
101510016658	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
101510016659	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510016660	S-adenosylmethionine binding site [chemical binding]; other site
101510016661	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
101510016662	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
101510016663	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
101510016664	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
101510016665	FeS/SAM binding site; other site
101510016666	Protein of unknown function (DUF2631); Region: DUF2631; pfam10939
101510016667	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
101510016668	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
101510016669	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
101510016670	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
101510016671	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
101510016672	active site
101510016673	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
101510016674	protein binding site [polypeptide binding]; other site
101510016675	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
101510016676	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694; cl15446
101510016677	Predicted acetyltransferase [General function prediction only]; Region: COG3393
101510016678	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
101510016679	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
101510016680	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
101510016681	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
101510016682	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368
101510016683	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368
101510016684	Amino acid permease; Region: AA_permease; cl00524
101510016685	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510016686	DNA binding residues [nucleotide binding]
101510016687	dimerization interface [polypeptide binding]; other site
101510016688	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
101510016689	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510016690	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
101510016691	2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050
101510016692	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510016693	dimer interface [polypeptide binding]; other site
101510016694	conserved gate region; other site
101510016695	putative PBP binding loops; other site
101510016696	ABC-ATPase subunit interface; other site
101510016697	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
101510016698	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510016699	Walker A/P-loop; other site
101510016700	ATP binding site [chemical binding]; other site
101510016701	Q-loop/lid; other site
101510016702	ABC transporter signature motif; other site
101510016703	Walker B; other site
101510016704	D-loop; other site
101510016705	H-loop/switch region; other site
101510016706	TOBE domain; Region: TOBE_2; cl01440
101510016707	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
101510016708	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
101510016709	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510016710	DNA-binding site [nucleotide binding]; DNA binding site
101510016711	UTRA domain; Region: UTRA; cl01230
101510016712	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
101510016713	active site
101510016714	cobyric acid synthase; Provisional; Region: PRK00784
101510016715	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510016716	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
101510016717	catalytic triad [active]
101510016718	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
101510016719	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
101510016720	Walker A/P-loop; other site
101510016721	ATP binding site [chemical binding]; other site
101510016722	Q-loop/lid; other site
101510016723	ABC transporter signature motif; other site
101510016724	Walker B; other site
101510016725	D-loop; other site
101510016726	H-loop/switch region; other site
101510016727	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510016728	Uncharacterised BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757
101510016729	mycothione reductase; Reviewed; Region: PRK07846
101510016730	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510016731	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
101510016732	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
101510016733	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510016734	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510016735	Predicted dehydrogenase [General function prediction only]; Region: COG0579
101510016736	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
101510016737	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510016738	magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030
101510016739	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
101510016740	metal ion-dependent adhesion site (MIDAS); other site
101510016741	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
101510016742	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
101510016743	Walker A motif; other site
101510016744	homodimer interface [polypeptide binding]; other site
101510016745	ATP binding site [chemical binding]; other site
101510016746	hydroxycobalamin binding site [chemical binding]; other site
101510016747	Walker B motif; other site
101510016748	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
101510016749	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510016750	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
101510016751	catalytic triad [active]
101510016752	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
101510016753	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
101510016754	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
101510016755	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510016756	putative substrate translocation pore; other site
101510016757	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510016758	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
101510016759	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
101510016760	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
101510016761	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510016762	active site
101510016763	phosphorylation site [posttranslational modification]
101510016764	intermolecular recognition site; other site
101510016765	dimerization interface [polypeptide binding]; other site
101510016766	Transcriptional regulator; Region: CitT; pfam12431
101510016767	Helix-turn-helix domains; Region: HTH; cl00088
101510016768	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
101510016769	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
101510016770	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510016771	ATP binding site [chemical binding]; other site
101510016772	Mg2+ binding site [ion binding]; other site
101510016773	G-X-G motif; other site
101510016774	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
101510016775	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
101510016776	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
101510016777	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
101510016778	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
101510016779	Ligand Binding Site [chemical binding]; other site
101510016780	Protein of unknown function (DUF328); Region: DUF328; cl01143
101510016781	prolyl-tRNA synthetase; Provisional; Region: PRK09194
101510016782	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
101510016783	motif 1; other site
101510016784	dimer interface [polypeptide binding]; other site
101510016785	active site
101510016786	motif 2; other site
101510016787	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
101510016788	putative deacylase active site [active]
101510016789	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
101510016790	active site
101510016791	motif 3; other site
101510016792	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
101510016793	anticodon binding site; other site
101510016794	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510016795	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
101510016796	active site
101510016797	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
101510016798	putative dimer interface [polypeptide binding]; other site
101510016799	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510016800	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510016801	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510016802	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
101510016803	phosphopeptide binding site; other site
101510016804	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510016805	DNA binding residues [nucleotide binding]
101510016806	dimerization interface [polypeptide binding]; other site
101510016807	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510016808	Helix-turn-helix domains; Region: HTH; cl00088
101510016809	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
101510016810	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510016811	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510016812	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
101510016813	NAD(P) binding site [chemical binding]; other site
101510016814	active site
101510016815	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl14784
101510016816	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
101510016817	dinuclear metal binding motif [ion binding]; other site
101510016818	ribosome maturation protein RimP; Reviewed; Region: PRK00092
101510016819	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
101510016820	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
101510016821	NusA N-terminal domain; Region: NusA_N; pfam08529
101510016822	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
101510016823	RNA binding site [nucleotide binding]; other site
101510016824	homodimer interface [polypeptide binding]; other site
101510016825	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
101510016826	G-X-X-G motif; other site
101510016827	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
101510016828	G-X-X-G motif; other site
101510016829	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189
101510016830	putative RNA binding cleft [nucleotide binding]; other site
101510016831	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
101510016832	translation initiation factor IF-2; Region: IF-2; TIGR00487
101510016833	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
101510016834	IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily.  IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits.  As seen in other GTPases; Region: IF2_eIF5B; cd01887
101510016835	G1 box; other site
101510016836	putative GEF interaction site [polypeptide binding]; other site
101510016837	GTP/Mg2+ binding site [chemical binding]; other site
101510016838	Switch I region; other site
101510016839	G2 box; other site
101510016840	G3 box; other site
101510016841	Switch II region; other site
101510016842	G4 box; other site
101510016843	G5 box; other site
101510016844	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
101510016845	Translation-initiation factor 2; Region: IF-2; pfam11987
101510016846	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
101510016847	Protein of unknown function (DUF503); Region: DUF503; cl00669
101510016848	Ribosome-binding factor A; Region: RBFA; cl00542
101510016849	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
101510016850	DHH family; Region: DHH; pfam01368
101510016851	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
101510016852	MatE; Region: MatE; cl10513
101510016853	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
101510016854	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
101510016855	active site
101510016856	metal binding site [ion binding]; metal-binding site
101510016857	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
101510016858	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
101510016859	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
101510016860	PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573
101510016861	RNA binding site [nucleotide binding]; other site
101510016862	active site
101510016863	Helix-turn-helix domains; Region: HTH; cl00088
101510016864	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
101510016865	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
101510016866	FeoA domain; Region: FeoA; cl00838
101510016867	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
101510016868	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
101510016869	active site
101510016870	Riboflavin kinase; Region: Flavokinase; cl03312
101510016871	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
101510016872	16S/18S rRNA binding site [nucleotide binding]; other site
101510016873	S13e-L30e interaction site [polypeptide binding]; other site
101510016874	25S rRNA binding site [nucleotide binding]; other site
101510016875	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
101510016876	3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
101510016877	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
101510016878	3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
101510016879	3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725
101510016880	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
101510016881	putative nucleic acid binding region [nucleotide binding]; other site
101510016882	G-X-X-G motif; other site
101510016883	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
101510016884	RNA binding site [nucleotide binding]; other site
101510016885	domain interface; other site
101510016886	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895
101510016887	Helix-turn-helix domains; Region: HTH; cl00088
101510016888	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
101510016889	putative dimerization interface [polypeptide binding]; other site
101510016890	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
101510016891	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510016892	putative substrate translocation pore; other site
101510016893	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510016894	S-adenosylmethionine binding site [chemical binding]; other site
101510016895	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865
101510016896	putative hydrophobic ligand binding site [chemical binding]; other site
101510016897	DinB superfamily; Region: DinB_2; cl00986
101510016898	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
101510016899	peptide synthase; Provisional; Region: PRK12316
101510016900	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510016901	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510016902	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510016903	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
101510016904	peptide synthase; Provisional; Region: PRK12316
101510016905	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510016906	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510016907	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510016908	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
101510016909	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510016910	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510016911	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
101510016912	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510016913	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510016914	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
101510016915	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
101510016916	Glutamine amidotransferase class-I; Region: GATase; pfam00117
101510016917	glutamine binding [chemical binding]; other site
101510016918	catalytic triad [active]
101510016919	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
101510016920	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
101510016921	chorismate binding enzyme; Region: Chorismate_bind; cl10555
101510016922	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510016923	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
101510016924	ATP binding site [chemical binding]; other site
101510016925	putative Mg++ binding site [ion binding]; other site
101510016926	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510016927	D-galactonate transporter; Region: 2A0114; TIGR00893
101510016928	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510016929	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
101510016930	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
101510016931	FMN-binding pocket [chemical binding]; other site
101510016932	flavin binding motif; other site
101510016933	phosphate binding motif [ion binding]; other site
101510016934	beta-alpha-beta structure motif; other site
101510016935	NAD binding pocket [chemical binding]; other site
101510016936	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510016937	catalytic loop [active]
101510016938	iron binding site [ion binding]; other site
101510016939	YCII-related domain; Region: YCII; cl00999
101510016940	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
101510016941	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510016942	NAD(P) binding site [chemical binding]; other site
101510016943	catalytic residues [active]
101510016944	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
101510016945	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510016946	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510016947	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
101510016948	enoyl-CoA hydratase; Provisional; Region: PRK09245
101510016949	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510016950	substrate binding site [chemical binding]; other site
101510016951	oxyanion hole (OAH) forming residues; other site
101510016952	trimer interface [polypeptide binding]; other site
101510016953	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510016954	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510016955	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510016956	active site
101510016957	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
101510016958	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
101510016959	CoA-transferase family III; Region: CoA_transf_3; pfam02515
101510016960	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510016961	Helix-turn-helix domains; Region: HTH; cl00088
101510016962	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510016963	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510016964	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
101510016965	substrate binding pocket [chemical binding]; other site
101510016966	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510016967	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510016968	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510016969	Stress responsive A/B Barrel Domain; Region: Dabb; cl06768
101510016970	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
101510016971	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
101510016972	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
101510016973	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
101510016974	putative NADH binding site [chemical binding]; other site
101510016975	putative active site [active]
101510016976	nudix motif; other site
101510016977	putative metal binding site [ion binding]; other site
101510016978	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
101510016979	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510016980	Helix-turn-helix domains; Region: HTH; cl00088
101510016981	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
101510016982	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510016983	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
101510016984	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
101510016985	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
101510016986	FMN binding site [chemical binding]; other site
101510016987	substrate binding site [chemical binding]; other site
101510016988	putative catalytic residue [active]
101510016989	enoyl-CoA hydratase; Provisional; Region: PRK08260
101510016990	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510016991	substrate binding site [chemical binding]; other site
101510016992	oxyanion hole (OAH) forming residues; other site
101510016993	trimer interface [polypeptide binding]; other site
101510016994	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510016995	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
101510016996	Domain of unknown function (DUF1931); Region: DUF1931; pfam09123
101510016997	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
101510016998	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510016999	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; cl09957
101510017000	thioredoxin 2; Provisional; Region: PRK10996
101510017001	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
101510017002	catalytic residues [active]
101510017003	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
101510017004	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
101510017005	Clp amino terminal domain; Region: Clp_N; pfam02861
101510017006	Clp amino terminal domain; Region: Clp_N; pfam02861
101510017007	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
101510017008	Walker A motif; other site
101510017009	ATP binding site [chemical binding]; other site
101510017010	Walker B motif; other site
101510017011	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
101510017012	arginine finger; other site
101510017013	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
101510017014	Walker A motif; other site
101510017015	ATP binding site [chemical binding]; other site
101510017016	Walker B motif; other site
101510017017	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
101510017018	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
101510017019	HSP70 interaction site [polypeptide binding]; other site
101510017020	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
101510017021	substrate binding site [polypeptide binding]; other site
101510017022	dimer interface [polypeptide binding]; other site
101510017023	heat shock protein GrpE; Provisional; Region: PRK14140
101510017024	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
101510017025	dimer interface [polypeptide binding]; other site
101510017026	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
101510017027	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
101510017028	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
101510017029	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
101510017030	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
101510017031	protein binding site [polypeptide binding]; other site
101510017032	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364
101510017033	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
101510017034	putative hydrophobic ligand binding site [chemical binding]; other site
101510017035	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510017036	S-adenosylmethionine binding site [chemical binding]; other site
101510017037	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865
101510017038	putative hydrophobic ligand binding site [chemical binding]; other site
101510017039	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
101510017040	DinB superfamily; Region: DinB_2; cl00986
101510017041	mce related protein; Region: MCE; cl15431
101510017042	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
101510017043	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510017044	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510017045	active site
101510017046	ATP binding site [chemical binding]; other site
101510017047	substrate binding site [chemical binding]; other site
101510017048	activation loop (A-loop); other site
101510017049	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
101510017050	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510017051	S-adenosylmethionine binding site [chemical binding]; other site
101510017052	Helix-turn-helix domains; Region: HTH; cl00088
101510017053	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
101510017054	hydrophobic ligand binding site; other site
101510017055	Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837
101510017056	Domain of unknown function DUF77; Region: DUF77; cl00307
101510017057	Predicted transcriptional regulator [Transcription]; Region: COG2378
101510017058	Helix-turn-helix domains; Region: HTH; cl00088
101510017059	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
101510017060	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510017061	active site
101510017062	metal binding site [ion binding]; metal-binding site
101510017063	Protein of unknown function (DUF419); Region: DUF419; cl15265
101510017064	DinB superfamily; Region: DinB_2; cl00986
101510017065	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
101510017066	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510017067	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
101510017068	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
101510017069	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
101510017070	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
101510017071	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614
101510017072	NAD(P) binding site [chemical binding]; other site
101510017073	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
101510017074	Protein of unknown function (DUF419); Region: DUF419; cl15265
101510017075	Transcriptional regulators [Transcription]; Region: MarR; COG1846
101510017076	Helix-turn-helix domains; Region: HTH; cl00088
101510017077	DinB superfamily; Region: DinB_2; cl00986
101510017078	dihydrodipicolinate reductase; Provisional; Region: PRK00048
101510017079	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510017080	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
101510017081	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
101510017082	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
101510017083	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
101510017084	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
101510017085	putative hydrophobic ligand binding site [chemical binding]; other site
101510017086	Ubiquitin-like proteins; Region: UBQ; cl00155
101510017087	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
101510017088	Thymidylate synthase complementing protein; Region: Thy1; cl03630
101510017089	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
101510017090	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
101510017091	dimer interface [polypeptide binding]; other site
101510017092	active site
101510017093	catalytic residue [active]
101510017094	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
101510017095	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510017096	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
101510017097	TIGR03085 family protein; Region: TIGR03085
101510017098	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510017099	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
101510017100	Integral membrane protein TerC family; Region: TerC; cl10468
101510017101	YCII-related domain; Region: YCII; cl00999
101510017102	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
101510017103	Coenzyme A binding pocket [chemical binding]; other site
101510017104	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
101510017105	Competence-damaged protein; Region: CinA; cl00666
101510017106	Helix-turn-helix domains; Region: HTH; cl00088
101510017107	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
101510017108	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
101510017109	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510017110	Helix-turn-helix domains; Region: HTH; cl00088
101510017111	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
101510017112	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
101510017113	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
101510017114	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
101510017115	recombinase A; Provisional; Region: recA; PRK09354
101510017116	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
101510017117	hexamer interface [polypeptide binding]; other site
101510017118	Walker A motif; other site
101510017119	ATP binding site [chemical binding]; other site
101510017120	Walker B motif; other site
101510017121	RecX family; Region: RecX; cl00936
101510017122	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510017123	dimer interface [polypeptide binding]; other site
101510017124	conserved gate region; other site
101510017125	putative PBP binding loops; other site
101510017126	ABC-ATPase subunit interface; other site
101510017127	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
101510017128	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510017129	dimer interface [polypeptide binding]; other site
101510017130	conserved gate region; other site
101510017131	putative PBP binding loops; other site
101510017132	ABC-ATPase subunit interface; other site
101510017133	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
101510017134	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
101510017135	substrate binding pocket [chemical binding]; other site
101510017136	membrane-bound complex binding site; other site
101510017137	hinge residues; other site
101510017138	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
101510017139	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
101510017140	Walker A/P-loop; other site
101510017141	ATP binding site [chemical binding]; other site
101510017142	Q-loop/lid; other site
101510017143	ABC transporter signature motif; other site
101510017144	Walker B; other site
101510017145	D-loop; other site
101510017146	H-loop/switch region; other site
101510017147	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
101510017148	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
101510017149	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
101510017150	FeS/SAM binding site; other site
101510017151	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
101510017152	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
101510017153	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
101510017154	The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951
101510017155	IPP transferase; Region: IPPT; cl00403
101510017156	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
101510017157	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
101510017158	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
101510017159	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
101510017160	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
101510017161	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
101510017162	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
101510017163	HflX subfamily.  A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily.  The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878
101510017164	G1 box; other site
101510017165	GTP/Mg2+ binding site [chemical binding]; other site
101510017166	Switch I region; other site
101510017167	G2 box; other site
101510017168	G3 box; other site
101510017169	Switch II region; other site
101510017170	G4 box; other site
101510017171	G5 box; other site
101510017172	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
101510017173	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
101510017174	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206
101510017175	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
101510017176	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
101510017177	active site
101510017178	phosphorylation site [posttranslational modification]
101510017179	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
101510017180	P-loop; other site
101510017181	active site
101510017182	phosphorylation site [posttranslational modification]
101510017183	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
101510017184	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
101510017185	putative substrate binding site [chemical binding]; other site
101510017186	putative ATP binding site [chemical binding]; other site
101510017187	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
101510017188	Helix-turn-helix domains; Region: HTH; cl00088
101510017189	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
101510017190	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
101510017191	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
101510017192	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
101510017193	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
101510017194	Permease family; Region: Xan_ur_permease; cl00967
101510017195	Permease family; Region: Xan_ur_permease; cl00967
101510017196	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510017197	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510017198	active site
101510017199	Helix-turn-helix domains; Region: HTH; cl00088
101510017200	LexA repressor; Validated; Region: PRK00215
101510017201	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
101510017202	Catalytic site [active]
101510017203	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107
101510017204	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
101510017205	ATP cone domain; Region: ATP-cone; pfam03477
101510017206	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
101510017207	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
101510017208	ATP binding site [chemical binding]; other site
101510017209	putative Mg++ binding site [ion binding]; other site
101510017210	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510017211	Helicase associated domain (HA2); Region: HA2; cl04503
101510017212	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
101510017213	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
101510017214	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510017215	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510017216	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510017217	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510017218	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510017219	putative substrate translocation pore; other site
101510017220	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
101510017221	putative aminotransferase; Validated; Region: PRK07480
101510017222	inhibitor-cofactor binding pocket; inhibition site
101510017223	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510017224	catalytic residue [active]
101510017225	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
101510017226	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
101510017227	Helix-turn-helix domains; Region: HTH; cl00088
101510017228	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
101510017229	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
101510017230	dimerization interface [polypeptide binding]; other site
101510017231	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
101510017232	dimerization interface [polypeptide binding]; other site
101510017233	substrate binding pocket [chemical binding]; other site
101510017234	ski2-like helicase; Provisional; Region: PRK02362
101510017235	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
101510017236	ATP binding site [chemical binding]; other site
101510017237	putative Mg++ binding site [ion binding]; other site
101510017238	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
101510017239	nucleotide binding region [chemical binding]; other site
101510017240	ATP-binding site [chemical binding]; other site
101510017241	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
101510017242	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510017243	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510017244	homoserine O-acetyltransferase; Provisional; Region: metX; cl15472
101510017245	PAC2 family; Region: PAC2; cl00847
101510017246	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510017247	PknH-like extracellular domain; Region: PknH_C; pfam14032
101510017248	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
101510017249	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
101510017250	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
101510017251	NAD binding site [chemical binding]; other site
101510017252	homodimer interface [polypeptide binding]; other site
101510017253	active site
101510017254	substrate binding site [chemical binding]; other site
101510017255	Helix-turn-helix domains; Region: HTH; cl00088
101510017256	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
101510017257	FeoA domain; Region: FeoA; cl00838
101510017258	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
101510017259	Histone deacetylase domain; Region: Hist_deacetyl; cl02986
101510017260	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
101510017261	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
101510017262	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510017263	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
101510017264	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
101510017265	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
101510017266	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
101510017267	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
101510017268	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
101510017269	DNA binding residues [nucleotide binding]
101510017270	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510017271	S-adenosylmethionine binding site [chemical binding]; other site
101510017272	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
101510017273	tegument protein UL11; Provisional; Region: PHA03356
101510017274	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
101510017275	Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918
101510017276	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
101510017277	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
101510017278	ATP binding site [chemical binding]; other site
101510017279	putative Mg++ binding site [ion binding]; other site
101510017280	Protein of unknown function (DUF952); Region: DUF952; cl01393
101510017281	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
101510017282	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
101510017283	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
101510017284	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
101510017285	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
101510017286	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
101510017287	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
101510017288	DNA binding residues [nucleotide binding]
101510017289	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
101510017290	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
101510017291	active site
101510017292	dimerization interface [polypeptide binding]; other site
101510017293	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
101510017294	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
101510017295	Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
101510017296	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
101510017297	trimer interface [polypeptide binding]; other site
101510017298	active site
101510017299	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
101510017300	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510017301	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
101510017302	generic binding surface II; other site
101510017303	ssDNA binding site; other site
101510017304	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
101510017305	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510017306	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
101510017307	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
101510017308	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510017309	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
101510017310	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
101510017311	TRAM domain; Region: TRAM; cl01282
101510017312	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
101510017313	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510017314	Helix-turn-helix domains; Region: HTH; cl00088
101510017315	Protein of unknown function (DUF541); Region: SIMPL; cl01077
101510017316	ABC-2 type transporter; Region: ABC2_membrane; cl11417
101510017317	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510017318	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
101510017319	Walker A/P-loop; other site
101510017320	ATP binding site [chemical binding]; other site
101510017321	Q-loop/lid; other site
101510017322	ABC transporter signature motif; other site
101510017323	Walker B; other site
101510017324	D-loop; other site
101510017325	H-loop/switch region; other site
101510017326	Glutaminase; Region: Glutaminase; cl00907
101510017327	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
101510017328	ligand binding site [chemical binding]; other site
101510017329	flexible hinge region; other site
101510017330	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
101510017331	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
101510017332	TPP-binding site; other site
101510017333	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
101510017334	PYR/PP interface [polypeptide binding]; other site
101510017335	dimer interface [polypeptide binding]; other site
101510017336	TPP binding site [chemical binding]; other site
101510017337	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
101510017338	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
101510017339	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510017340	putative substrate translocation pore; other site
101510017341	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510017342	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
101510017343	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
101510017344	siderophore binding site; other site
101510017345	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
101510017346	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510017347	DNA-binding site [nucleotide binding]; DNA binding site
101510017348	UTRA domain; Region: UTRA; cl01230
101510017349	archaeoflavoprotein, MJ0208 family; Region: flavo_MJ0208; TIGR02700
101510017350	ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521
101510017351	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
101510017352	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
101510017353	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510017354	dimer interface [polypeptide binding]; other site
101510017355	conserved gate region; other site
101510017356	putative PBP binding loops; other site
101510017357	ABC-ATPase subunit interface; other site
101510017358	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
101510017359	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
101510017360	Walker A/P-loop; other site
101510017361	ATP binding site [chemical binding]; other site
101510017362	Q-loop/lid; other site
101510017363	ABC transporter signature motif; other site
101510017364	Walker B; other site
101510017365	D-loop; other site
101510017366	H-loop/switch region; other site
101510017367	putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800
101510017368	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510017369	domain; Region: Succ_DH_flav_C; pfam02910
101510017370	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
101510017371	protein binding surface [polypeptide binding]; other site
101510017372	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510017373	substrate binding site [chemical binding]; other site
101510017374	oxyanion hole (OAH) forming residues; other site
101510017375	trimer interface [polypeptide binding]; other site
101510017376	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
101510017377	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510017378	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
101510017379	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
101510017380	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
101510017381	dimer interface [polypeptide binding]; other site
101510017382	active site
101510017383	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
101510017384	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
101510017385	putative active site [active]
101510017386	catalytic site [active]
101510017387	putative substrate binding site [chemical binding]; other site
101510017388	HRDC domain; Region: HRDC; cl02578
101510017389	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
101510017390	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
101510017391	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510017392	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
101510017393	substrate binding pocket [chemical binding]; other site
101510017394	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510017395	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
101510017396	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
101510017397	substrate binding site [chemical binding]; other site
101510017398	active site
101510017399	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510017400	Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232
101510017401	Chlorite dismutase; Region: Chlor_dismutase; cl01280
101510017402	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
101510017403	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
101510017404	molybdopterin cofactor binding site [chemical binding]; other site
101510017405	substrate binding site [chemical binding]; other site
101510017406	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
101510017407	molybdopterin cofactor binding site; other site
101510017408	SelR domain; Region: SelR; cl00369
101510017409	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
101510017410	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510017411	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510017412	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
101510017413	AFG1-like ATPase; Region: AFG1_ATPase; pfam03969
101510017414	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510017415	Walker A motif; other site
101510017416	ATP binding site [chemical binding]; other site
101510017417	Walker B motif; other site
101510017418	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
101510017419	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
101510017420	Coenzyme A binding pocket [chemical binding]; other site
101510017421	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510017422	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
101510017423	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780
101510017424	hypothetical protein; Reviewed; Region: PRK09588
101510017425	Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870
101510017426	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
101510017427	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
101510017428	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
101510017429	active site
101510017430	dimer interface [polypeptide binding]; other site
101510017431	motif 1; other site
101510017432	motif 2; other site
101510017433	motif 3; other site
101510017434	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
101510017435	anticodon binding site; other site
101510017436	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
101510017437	nucleotide binding site/active site [active]
101510017438	HIT family signature motif; other site
101510017439	catalytic residue [active]
101510017440	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
101510017441	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
101510017442	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
101510017443	putative acyl-acceptor binding pocket; other site
101510017444	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
101510017445	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
101510017446	LemA family; Region: LemA; cl00742
101510017447	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685
101510017448	nudix motif; other site
101510017449	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
101510017450	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
101510017451	active site
101510017452	multimer interface [polypeptide binding]; other site
101510017453	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
101510017454	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
101510017455	active site
101510017456	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
101510017457	catalytic triad [active]
101510017458	dimer interface [polypeptide binding]; other site
101510017459	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510017460	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
101510017461	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
101510017462	active site
101510017463	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
101510017464	catalytic triad [active]
101510017465	dimer interface [polypeptide binding]; other site
101510017466	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
101510017467	predicted active site [active]
101510017468	catalytic triad [active]
101510017469	Predicted transcriptional regulators [Transcription]; Region: COG1725
101510017470	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510017471	DNA-binding site [nucleotide binding]; DNA binding site
101510017472	Domain of unknown function DUF28; Region: DUF28; cl00361
101510017473	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
101510017474	active site
101510017475	putative DNA-binding cleft [nucleotide binding]; other site
101510017476	dimer interface [polypeptide binding]; other site
101510017477	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
101510017478	RuvA N terminal domain; Region: RuvA_N; pfam01330
101510017479	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
101510017480	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
101510017481	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
101510017482	Walker A motif; other site
101510017483	ATP binding site [chemical binding]; other site
101510017484	Walker B motif; other site
101510017485	arginine finger; other site
101510017486	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
101510017487	Preprotein translocase subunit; Region: YajC; cl00806
101510017488	protein-export membrane protein SecD; Region: secD; TIGR01129
101510017489	Protein export membrane protein; Region: SecD_SecF; cl14618
101510017490	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
101510017491	Protein export membrane protein; Region: SecD_SecF; cl14618
101510017492	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
101510017493	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
101510017494	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
101510017495	(p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691
101510017496	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
101510017497	Zn2+ binding site [ion binding]; other site
101510017498	Mg2+ binding site [ion binding]; other site
101510017499	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
101510017500	synthetase active site [active]
101510017501	NTP binding site [chemical binding]; other site
101510017502	metal binding site [ion binding]; metal-binding site
101510017503	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
101510017504	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
101510017505	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
101510017506	active site
101510017507	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
101510017508	active site
101510017509	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510017510	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
101510017511	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
101510017512	dimer interface [polypeptide binding]; other site
101510017513	motif 1; other site
101510017514	active site
101510017515	motif 2; other site
101510017516	motif 3; other site
101510017517	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
101510017518	anticodon binding site; other site
101510017519	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
101510017520	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
101510017521	putative transposase OrfB; Reviewed; Region: PHA02517
101510017522	Integrase core domain; Region: rve; cl01316
101510017523	Helix-turn-helix domains; Region: HTH; cl00088
101510017524	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
101510017525	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510017526	DNA binding site [nucleotide binding]
101510017527	Int/Topo IB signature motif; other site
101510017528	active site
101510017529	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510017530	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
101510017531	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
101510017532	Walker A motif; other site
101510017533	ATP binding site [chemical binding]; other site
101510017534	Walker B motif; other site
101510017535	Transposase; Region: DEDD_Tnp_IS110; pfam01548
101510017536	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
101510017537	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510017538	Helix-turn-helix domains; Region: HTH; cl00088
101510017539	Amino acid permease; Region: AA_permease; cl00524
101510017540	Domain of unknown function (DUF1989); Region: DUF1989; cl01474
101510017541	Domain of unknown function (DUF1989); Region: DUF1989; cl01474
101510017542	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
101510017543	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
101510017544	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
101510017545	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
101510017546	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896
101510017547	putative hydrophobic ligand binding site [chemical binding]; other site
101510017548	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
101510017549	dimerization interface [polypeptide binding]; other site
101510017550	putative DNA binding site [nucleotide binding]; other site
101510017551	putative Zn2+ binding site [ion binding]; other site
101510017552	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
101510017553	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510017554	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
101510017555	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
101510017556	Zn2+ binding site [ion binding]; other site
101510017557	Mg2+ binding site [ion binding]; other site
101510017558	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510017559	DNA binding residues [nucleotide binding]
101510017560	dimerization interface [polypeptide binding]; other site
101510017561	ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR).  DR is a well-described phenomenon occurring in fungi and shares several similarities with processes...; Region: ABCG_EPDR; cd03213
101510017562	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
101510017563	Walker A/P-loop; other site
101510017564	ATP binding site [chemical binding]; other site
101510017565	Q-loop/lid; other site
101510017566	ABC transporter signature motif; other site
101510017567	Walker B; other site
101510017568	D-loop; other site
101510017569	H-loop/switch region; other site
101510017570	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
101510017571	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
101510017572	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
101510017573	Transglycosylase; Region: Transgly; cl07896
101510017574	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
101510017575	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
101510017576	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
101510017577	dimer interface [polypeptide binding]; other site
101510017578	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
101510017579	chaperone protein DnaJ; Provisional; Region: PRK14279
101510017580	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
101510017581	HSP70 interaction site [polypeptide binding]; other site
101510017582	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
101510017583	Zn binding sites [ion binding]; other site
101510017584	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
101510017585	dimer interface [polypeptide binding]; other site
101510017586	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
101510017587	metal binding site [ion binding]; metal-binding site
101510017588	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510017589	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
101510017590	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510017591	DNA binding residues [nucleotide binding]
101510017592	dimerization interface [polypeptide binding]; other site
101510017593	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510017594	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510017595	active site
101510017596	ATP binding site [chemical binding]; other site
101510017597	substrate binding site [chemical binding]; other site
101510017598	activation loop (A-loop); other site
101510017599	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510017600	Transposase; Region: DEDD_Tnp_IS110; pfam01548
101510017601	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
101510017602	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510017603	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
101510017604	active site residue [active]
101510017605	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
101510017606	active site residue [active]
101510017607	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
101510017608	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
101510017609	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
101510017610	dimer interface [polypeptide binding]; other site
101510017611	decamer (pentamer of dimers) interface [polypeptide binding]; other site
101510017612	catalytic triad [active]
101510017613	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
101510017614	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
101510017615	Walker A/P-loop; other site
101510017616	ATP binding site [chemical binding]; other site
101510017617	Q-loop/lid; other site
101510017618	ABC transporter signature motif; other site
101510017619	Walker B; other site
101510017620	D-loop; other site
101510017621	H-loop/switch region; other site
101510017622	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
101510017623	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
101510017624	substrate binding pocket [chemical binding]; other site
101510017625	membrane-bound complex binding site; other site
101510017626	hinge residues; other site
101510017627	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
101510017628	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510017629	dimer interface [polypeptide binding]; other site
101510017630	conserved gate region; other site
101510017631	putative PBP binding loops; other site
101510017632	ABC-ATPase subunit interface; other site
101510017633	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
101510017634	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510017635	dimer interface [polypeptide binding]; other site
101510017636	conserved gate region; other site
101510017637	putative PBP binding loops; other site
101510017638	ABC-ATPase subunit interface; other site
101510017639	Helix-turn-helix domains; Region: HTH; cl00088
101510017640	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510017641	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510017642	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
101510017643	CoA-transferase family III; Region: CoA_transf_3; pfam02515
101510017644	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
101510017645	Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100
101510017646	active site
101510017647	citrylCoA binding site [chemical binding]; other site
101510017648	oxalacetate binding site [chemical binding]; other site
101510017649	coenzyme A binding site [chemical binding]; other site
101510017650	catalytic triad [active]
101510017651	Putative cyclase; Region: Cyclase; cl00814
101510017652	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
101510017653	CoenzymeA binding site [chemical binding]; other site
101510017654	subunit interaction site [polypeptide binding]; other site
101510017655	PHB binding site; other site
101510017656	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
101510017657	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
101510017658	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510017659	Major Facilitator Superfamily; Region: MFS_1; pfam07690
101510017660	putative substrate translocation pore; other site
101510017661	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510017662	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
101510017663	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
101510017664	PhoU domain; Region: PhoU; pfam01895
101510017665	PhoU domain; Region: PhoU; pfam01895
101510017666	inosine-5'-monophosphate dehydrogenase; Region: IMP_dehydrog; TIGR01302
101510017667	Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326
101510017668	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
101510017669	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
101510017670	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510017671	Phage integrase family; Region: Phage_integrase; pfam00589
101510017672	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510017673	DNA binding site [nucleotide binding]
101510017674	Int/Topo IB signature motif; other site
101510017675	active site
101510017676	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
101510017677	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
101510017678	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510017679	DNA binding site [nucleotide binding]
101510017680	Int/Topo IB signature motif; other site
101510017681	active site
101510017682	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510017683	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
101510017684	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510017685	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
101510017686	Prostaglandin dehydrogenases; Region: PGDH; cd05288
101510017687	NAD(P) binding site [chemical binding]; other site
101510017688	substrate binding site [chemical binding]; other site
101510017689	dimer interface [polypeptide binding]; other site
101510017690	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960
101510017691	NodB motif; other site
101510017692	putative active site [active]
101510017693	putative catalytic site [active]
101510017694	putative Zn binding site [ion binding]; other site
101510017695	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
101510017696	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510017697	Helix-turn-helix domain; Region: HTH_18; pfam12833
101510017698	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510017699	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510017700	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
101510017701	NAD(P) binding site [chemical binding]; other site
101510017702	active site
101510017703	Helix-turn-helix domains; Region: HTH; cl00088
101510017704	Cupin domain; Region: Cupin_2; cl09118
101510017705	Secretory lipase; Region: LIP; pfam03583
101510017706	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
101510017707	DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975
101510017708	Helix-turn-helix domains; Region: HTH; cl00088
101510017709	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
101510017710	active site
101510017711	catalytic site [active]
101510017712	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
101510017713	Helix-turn-helix domains; Region: HTH; cl00088
101510017714	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
101510017715	putative hydrophobic ligand binding site [chemical binding]; other site
101510017716	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
101510017717	Integrase core domain; Region: rve; cl01316
101510017718	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
101510017719	Secretory lipase; Region: LIP; pfam03583
101510017720	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
101510017721	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510017722	TIGR03118 family protein; Region: PEPCTERM_chp_1
101510017723	Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970
101510017724	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
101510017725	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510017726	Walker A/P-loop; other site
101510017727	ATP binding site [chemical binding]; other site
101510017728	Q-loop/lid; other site
101510017729	ABC transporter signature motif; other site
101510017730	Walker B; other site
101510017731	D-loop; other site
101510017732	H-loop/switch region; other site
101510017733	TOBE domain; Region: TOBE_2; cl01440
101510017734	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
101510017735	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510017736	putative PBP binding loops; other site
101510017737	ABC-ATPase subunit interface; other site
101510017738	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510017739	dimer interface [polypeptide binding]; other site
101510017740	conserved gate region; other site
101510017741	putative PBP binding loops; other site
101510017742	ABC-ATPase subunit interface; other site
101510017743	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
101510017744	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
101510017745	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
101510017746	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510017747	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510017748	Vitamin K epoxide reductase family; Region: VKOR; cl01729
101510017749	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
101510017750	Bacterial Ig-like domain; Region: Big_5; cl01012
101510017751	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510017752	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510017753	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
101510017754	Walker A/P-loop; other site
101510017755	ATP binding site [chemical binding]; other site
101510017756	Q-loop/lid; other site
101510017757	ABC transporter signature motif; other site
101510017758	Walker B; other site
101510017759	D-loop; other site
101510017760	H-loop/switch region; other site
101510017761	ABC-2 type transporter; Region: ABC2_membrane; cl11417
101510017762	RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637
101510017763	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
101510017764	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358
101510017765	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
101510017766	Helix-turn-helix domains; Region: HTH; cl00088
101510017767	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510017768	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510017769	NMT1/THI5 like; Region: NMT1; pfam09084
101510017770	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
101510017771	substrate binding pocket [chemical binding]; other site
101510017772	membrane-bound complex binding site; other site
101510017773	hinge residues; other site
101510017774	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
101510017775	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510017776	dimer interface [polypeptide binding]; other site
101510017777	conserved gate region; other site
101510017778	putative PBP binding loops; other site
101510017779	ABC-ATPase subunit interface; other site
101510017780	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
101510017781	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510017782	Walker A/P-loop; other site
101510017783	ATP binding site [chemical binding]; other site
101510017784	Q-loop/lid; other site
101510017785	ABC transporter signature motif; other site
101510017786	Walker B; other site
101510017787	D-loop; other site
101510017788	H-loop/switch region; other site
101510017789	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
101510017790	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510017791	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
101510017792	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
101510017793	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510017794	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
101510017795	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
101510017796	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
101510017797	substrate binding pocket [chemical binding]; other site
101510017798	membrane-bound complex binding site; other site
101510017799	hinge residues; other site
101510017800	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
101510017801	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510017802	ATP binding site [chemical binding]; other site
101510017803	Mg2+ binding site [ion binding]; other site
101510017804	G-X-G motif; other site
101510017805	Lsr2; Region: Lsr2; pfam11774
101510017806	Lsr2; Region: Lsr2; pfam11774
101510017807	Lsr2; Region: Lsr2; pfam11774
101510017808	Lsr2; Region: Lsr2; pfam11774
101510017809	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510017810	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
101510017811	active site
101510017812	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
101510017813	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510017814	active site
101510017815	enoyl-CoA hydratase; Provisional; Region: PRK06495
101510017816	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510017817	substrate binding site [chemical binding]; other site
101510017818	oxyanion hole (OAH) forming residues; other site
101510017819	trimer interface [polypeptide binding]; other site
101510017820	cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295
101510017821	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510017822	Transcriptional regulators [Transcription]; Region: FadR; COG2186
101510017823	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510017824	DNA-binding site [nucleotide binding]; DNA binding site
101510017825	FCD domain; Region: FCD; cl11656
101510017826	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510017827	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510017828	putative substrate translocation pore; other site
101510017829	enoyl-CoA hydratase; Provisional; Region: PRK05862
101510017830	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510017831	substrate binding site [chemical binding]; other site
101510017832	oxyanion hole (OAH) forming residues; other site
101510017833	trimer interface [polypeptide binding]; other site
101510017834	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
101510017835	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510017836	substrate binding site [chemical binding]; other site
101510017837	oxyanion hole (OAH) forming residues; other site
101510017838	trimer interface [polypeptide binding]; other site
101510017839	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510017840	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
101510017841	substrate binding pocket [chemical binding]; other site
101510017842	FAD binding site [chemical binding]; other site
101510017843	catalytic base [active]
101510017844	Helix-turn-helix domains; Region: HTH; cl00088
101510017845	Transcriptional regulator [Transcription]; Region: LysR; COG0583
101510017846	Helix-turn-helix domains; Region: HTH; cl00088
101510017847	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
101510017848	dimerization interface [polypeptide binding]; other site
101510017849	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
101510017850	CoA-transferase family III; Region: CoA_transf_3; pfam02515
101510017851	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510017852	Magnetospirillum NAD(P)+-dependent aldehyde dehydrogenase MSR-1-like; Region: ALDH_MGR_2402; cd07108
101510017853	NAD(P) binding site [chemical binding]; other site
101510017854	catalytic residues [active]
101510017855	catalytic residues [active]
101510017856	adenylate kinase; Reviewed; Region: adk; PRK00279
101510017857	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
101510017858	AMP-binding site [chemical binding]; other site
101510017859	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
101510017860	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510017861	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
101510017862	Transposase, Mutator family; Region: Transposase_mut; pfam00872
101510017863	MULE transposase domain; Region: MULE; pfam10551
101510017864	Epoxide hydrolase N terminus; Region: EHN; pfam06441
101510017865	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510017866	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
101510017867	CGNR zinc finger; Region: zf-CGNR; pfam11706
101510017868	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
101510017869	Cupin domain; Region: Cupin_2; cl09118
101510017870	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
101510017871	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510017872	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
101510017873	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
101510017874	inhibitor site; inhibition site
101510017875	active site
101510017876	dimer interface [polypeptide binding]; other site
101510017877	catalytic residue [active]
101510017878	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510017879	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
101510017880	putative substrate translocation pore; other site
101510017881	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
101510017882	Coenzyme A binding pocket [chemical binding]; other site
101510017883	Ferredoxin [Energy production and conversion]; Region: COG1146
101510017884	4Fe-4S binding domain; Region: Fer4; cl02805
101510017885	ferredoxin-NADP+ reductase; Region: PLN02852
101510017886	hypothetical protein; Provisional; Region: PRK09897
101510017887	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
101510017888	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510017889	Helix-turn-helix domains; Region: HTH; cl00088
101510017890	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
101510017891	active site
101510017892	Zn binding site [ion binding]; other site
101510017893	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
101510017894	active site
101510017895	metal binding site [ion binding]; metal-binding site
101510017896	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510017897	Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970
101510017898	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
101510017899	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510017900	putative substrate translocation pore; other site
101510017901	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510017902	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510017903	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
101510017904	Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221
101510017905	acyl-CoA binding pocket [chemical binding]; other site
101510017906	CoA binding site [chemical binding]; other site
101510017907	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
101510017908	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510017909	S-adenosylmethionine binding site [chemical binding]; other site
101510017910	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
101510017911	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510017912	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825
101510017913	putative hydrophobic ligand binding site [chemical binding]; other site
101510017914	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
101510017915	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
101510017916	conserved cys residue [active]
101510017917	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
101510017918	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
101510017919	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
101510017920	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
101510017921	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
101510017922	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
101510017923	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
101510017924	FMN-binding pocket [chemical binding]; other site
101510017925	flavin binding motif; other site
101510017926	phosphate binding motif [ion binding]; other site
101510017927	beta-alpha-beta structure motif; other site
101510017928	NAD binding pocket [chemical binding]; other site
101510017929	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510017930	catalytic loop [active]
101510017931	iron binding site [ion binding]; other site
101510017932	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
101510017933	putative hydrophobic ligand binding site [chemical binding]; other site
101510017934	protein interface [polypeptide binding]; other site
101510017935	gate; other site
101510017936	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
101510017937	short chain dehydrogenase; Provisional; Region: PRK05872
101510017938	classical (c) SDRs; Region: SDR_c; cd05233
101510017939	NAD(P) binding site [chemical binding]; other site
101510017940	active site
101510017941	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
101510017942	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510017943	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510017944	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510017945	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510017946	active site
101510017947	Phosphotransferase enzyme family; Region: APH; pfam01636
101510017948	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
101510017949	homotrimer interaction site [polypeptide binding]; other site
101510017950	putative active site [active]
101510017951	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
101510017952	Radical SAM superfamily; Region: Radical_SAM; pfam04055
101510017953	FeS/SAM binding site; other site
101510017954	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
101510017955	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
101510017956	hydrophobic ligand binding site; other site
101510017957	Helix-turn-helix domains; Region: HTH; cl00088
101510017958	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988
101510017959	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
101510017960	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
101510017961	dimer interface [polypeptide binding]; other site
101510017962	anticodon binding site; other site
101510017963	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
101510017964	homodimer interface [polypeptide binding]; other site
101510017965	motif 1; other site
101510017966	active site
101510017967	motif 2; other site
101510017968	GAD domain; Region: GAD; pfam02938
101510017969	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
101510017970	active site
101510017971	motif 3; other site
101510017972	Domain of unknown function (DUF389); Region: DUF389; cl00781
101510017973	Domain of unknown function (DUF389); Region: DUF389; cl00781
101510017974	Uncharacterized conserved protein [Function unknown]; Region: COG2308
101510017975	Domain of unknown function (DUF404); Region: DUF404; pfam04169
101510017976	Domain of unknown function (DUF407); Region: DUF407; pfam04174
101510017977	Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980
101510017978	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
101510017979	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
101510017980	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691
101510017981	active site
101510017982	ATP binding site [chemical binding]; other site
101510017983	substrate binding site [chemical binding]; other site
101510017984	recombination factor protein RarA; Reviewed; Region: PRK13342
101510017985	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
101510017986	Walker A motif; other site
101510017987	ATP binding site [chemical binding]; other site
101510017988	Walker B motif; other site
101510017989	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
101510017990	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
101510017991	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673
101510017992	motif 1; other site
101510017993	active site
101510017994	motif 2; other site
101510017995	motif 3; other site
101510017996	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
101510017997	DHHA1 domain; Region: DHHA1; pfam02272
101510017998	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
101510017999	YceG-like family; Region: YceG; pfam02618
101510018000	proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675
101510018001	dimerization interface [polypeptide binding]; other site
101510018002	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
101510018003	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
101510018004	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
101510018005	NAD(P) binding site [chemical binding]; other site
101510018006	shikimate binding site; other site
101510018007	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cl00323
101510018008	Tetramer interface [polypeptide binding]; other site
101510018009	active site
101510018010	FMN-binding site [chemical binding]; other site
101510018011	shikimate kinase; Reviewed; Region: aroK; PRK00131
101510018012	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
101510018013	ADP binding site [chemical binding]; other site
101510018014	magnesium binding site [ion binding]; other site
101510018015	putative shikimate binding site; other site
101510018016	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
101510018017	active site
101510018018	dimer interface [polypeptide binding]; other site
101510018019	metal binding site [ion binding]; metal-binding site
101510018020	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
101510018021	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
101510018022	active site
101510018023	elongation factor P; Validated; Region: PRK00529
101510018024	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
101510018025	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
101510018026	RNA binding site [nucleotide binding]; other site
101510018027	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
101510018028	RNA binding site [nucleotide binding]; other site
101510018029	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
101510018030	putative RNA binding site [nucleotide binding]; other site
101510018031	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
101510018032	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
101510018033	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
101510018034	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510018035	dihydroorotase; Validated; Region: pyrC; PRK09357
101510018036	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
101510018037	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
101510018038	active site
101510018039	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
101510018040	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
101510018041	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
101510018042	catalytic site [active]
101510018043	subunit interface [polypeptide binding]; other site
101510018044	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
101510018045	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
101510018046	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
101510018047	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
101510018048	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
101510018049	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
101510018050	IMP binding site; other site
101510018051	dimer interface [polypeptide binding]; other site
101510018052	interdomain contacts; other site
101510018053	partial ornithine binding site; other site
101510018054	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
101510018055	active site
101510018056	dimer interface [polypeptide binding]; other site
101510018057	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
101510018058	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
101510018059	catalytic site [active]
101510018060	G-X2-G-X-G-K; other site
101510018061	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
101510018062	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
101510018063	Flavoprotein; Region: Flavoprotein; cl08021
101510018064	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
101510018065	S-adenosylmethionine synthetase; Validated; Region: PRK05250
101510018066	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
101510018067	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
101510018068	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
101510018069	primosome assembly protein PriA; Provisional; Region: PRK14873
101510018070	hypothetical protein; Provisional; Region: PRK06834
101510018071	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510018072	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510018073	Helix-turn-helix domains; Region: HTH; cl00088
101510018074	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965
101510018075	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510018076	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
101510018077	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
101510018078	putative active site [active]
101510018079	substrate binding site [chemical binding]; other site
101510018080	putative cosubstrate binding site; other site
101510018081	catalytic site [active]
101510018082	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
101510018083	substrate binding site [chemical binding]; other site
101510018084	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
101510018085	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
101510018086	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510018087	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
101510018088	classical (c) SDRs; Region: SDR_c; cd05233
101510018089	NAD(P) binding site [chemical binding]; other site
101510018090	active site
101510018091	Protein of unknown function (DUF419); Region: DUF419; cl15265
101510018092	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
101510018093	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
101510018094	substrate binding site [chemical binding]; other site
101510018095	hexamer interface [polypeptide binding]; other site
101510018096	metal binding site [ion binding]; metal-binding site
101510018097	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
101510018098	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
101510018099	catalytic motif [active]
101510018100	Zn binding site [ion binding]; other site
101510018101	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
101510018102	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
101510018103	Lumazine binding domain; Region: Lum_binding; pfam00677
101510018104	Lumazine binding domain; Region: Lum_binding; pfam00677
101510018105	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
101510018106	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
101510018107	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
101510018108	dimerization interface [polypeptide binding]; other site
101510018109	active site
101510018110	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
101510018111	homopentamer interface [polypeptide binding]; other site
101510018112	active site
101510018113	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
101510018114	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
101510018115	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
101510018116	GIY-YIG motif/motif A; other site
101510018117	active site
101510018118	catalytic site [active]
101510018119	putative DNA binding site [nucleotide binding]; other site
101510018120	metal binding site [ion binding]; metal-binding site
101510018121	UvrB/uvrC motif; Region: UVR; pfam02151
101510018122	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
101510018123	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
101510018124	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510018125	Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660
101510018126	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
101510018127	Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933
101510018128	phosphate binding site [ion binding]; other site
101510018129	putative substrate binding pocket [chemical binding]; other site
101510018130	dimer interface [polypeptide binding]; other site
101510018131	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
101510018132	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
101510018133	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267
101510018134	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
101510018135	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
101510018136	Phosphoglycerate kinase; Region: PGK; pfam00162
101510018137	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
101510018138	substrate binding site [chemical binding]; other site
101510018139	hinge regions; other site
101510018140	ADP binding site [chemical binding]; other site
101510018141	catalytic site [active]
101510018142	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
101510018143	substrate binding site [chemical binding]; other site
101510018144	dimer interface [polypeptide binding]; other site
101510018145	catalytic triad [active]
101510018146	Phosphoenolpyruvate carboxylase [Carbohydrate transport and    metabolism; Energy production and conversion]; Region: COG1892; cl14656
101510018147	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
101510018148	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
101510018149	putative active site [active]
101510018150	opcA protein; Region: OpcA; TIGR00534
101510018151	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359
101510018152	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
101510018153	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
101510018154	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
101510018155	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
101510018156	putative active site [active]
101510018157	transaldolase; Provisional; Region: PRK03903
101510018158	catalytic residue [active]
101510018159	transketolase; Reviewed; Region: PRK05899
101510018160	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
101510018161	TPP-binding site [chemical binding]; other site
101510018162	dimer interface [polypeptide binding]; other site
101510018163	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
101510018164	PYR/PP interface [polypeptide binding]; other site
101510018165	dimer interface [polypeptide binding]; other site
101510018166	TPP binding site [chemical binding]; other site
101510018167	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
101510018168	UbiA prenyltransferase family; Region: UbiA; cl00337
101510018169	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
101510018170	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
101510018171	NADP binding site [chemical binding]; other site
101510018172	dimer interface [polypeptide binding]; other site
101510018173	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
101510018174	ABC-2 type transporter; Region: ABC2_membrane; cl11417
101510018175	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
101510018176	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
101510018177	Walker A/P-loop; other site
101510018178	ATP binding site [chemical binding]; other site
101510018179	Q-loop/lid; other site
101510018180	ABC transporter signature motif; other site
101510018181	Walker B; other site
101510018182	D-loop; other site
101510018183	H-loop/switch region; other site
101510018184	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
101510018185	Predicted transcriptional regulator [Transcription]; Region: COG2345
101510018186	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
101510018187	putative DNA binding site [nucleotide binding]; other site
101510018188	putative Zn2+ binding site [ion binding]; other site
101510018189	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
101510018190	FeS assembly protein SufB; Region: sufB; TIGR01980
101510018191	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
101510018192	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
101510018193	FeS assembly ATPase SufC; Region: sufC; TIGR01978
101510018194	ABC-type transport system involved in Fe-S cluster assembly, ATPase component.  Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems.  The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217
101510018195	Walker A/P-loop; other site
101510018196	ATP binding site [chemical binding]; other site
101510018197	Q-loop/lid; other site
101510018198	ABC transporter signature motif; other site
101510018199	Walker B; other site
101510018200	D-loop; other site
101510018201	H-loop/switch region; other site
101510018202	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
101510018203	Aminotransferase class-V; Region: Aminotran_5; pfam00266
101510018204	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
101510018205	catalytic residue [active]
101510018206	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
101510018207	trimerization site [polypeptide binding]; other site
101510018208	active site
101510018209	Domain of unknown function DUF59; Region: DUF59; cl00941
101510018210	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
101510018211	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
101510018212	putative DNA binding site [nucleotide binding]; other site
101510018213	putative homodimer interface [polypeptide binding]; other site
101510018214	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510018215	lycopene cyclase family protein; Region: carotene-cycl; TIGR01790
101510018216	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
101510018217	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510018218	Walker A/P-loop; other site
101510018219	ATP binding site [chemical binding]; other site
101510018220	Q-loop/lid; other site
101510018221	ABC transporter signature motif; other site
101510018222	Walker B; other site
101510018223	D-loop; other site
101510018224	H-loop/switch region; other site
101510018225	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
101510018226	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510018227	Helix-turn-helix domains; Region: HTH; cl00088
101510018228	aconitate hydratase; Validated; Region: PRK09277
101510018229	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
101510018230	substrate binding site [chemical binding]; other site
101510018231	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
101510018232	ligand binding site [chemical binding]; other site
101510018233	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
101510018234	substrate binding site [chemical binding]; other site
101510018235	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
101510018236	NlpC/P60 family; Region: NLPC_P60; cl11438
101510018237	MoxR-like ATPases [General function prediction only]; Region: COG0714
101510018238	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
101510018239	Walker A motif; other site
101510018240	ATP binding site [chemical binding]; other site
101510018241	Walker B motif; other site
101510018242	arginine finger; other site
101510018243	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510018244	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
101510018245	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
101510018246	hypothetical protein; Provisional; Region: PRK13685
101510018247	Aerotolerance regulator N-terminal; Region: BatA; cl06567
101510018248	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
101510018249	metal ion-dependent adhesion site (MIDAS); other site
101510018250	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
101510018251	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
101510018252	NAD(P) binding site [chemical binding]; other site
101510018253	homotetramer interface [polypeptide binding]; other site
101510018254	homodimer interface [polypeptide binding]; other site
101510018255	active site
101510018256	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
101510018257	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510018258	NAD(P) binding site [chemical binding]; other site
101510018259	active site
101510018260	ferrochelatase; Reviewed; Region: hemH; PRK00035
101510018261	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
101510018262	C-terminal domain interface [polypeptide binding]; other site
101510018263	active site
101510018264	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
101510018265	active site
101510018266	N-terminal domain interface [polypeptide binding]; other site
101510018267	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
101510018268	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
101510018269	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
101510018270	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
101510018271	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
101510018272	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
101510018273	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
101510018274	catalytic residue [active]
101510018275	Transposase; Region: DEDD_Tnp_IS110; pfam01548
101510018276	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
101510018277	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
101510018278	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
101510018279	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510018280	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
101510018281	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
101510018282	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
101510018283	heterodimer interface [polypeptide binding]; other site
101510018284	substrate interaction site [chemical binding]; other site
101510018285	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
101510018286	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
101510018287	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
101510018288	active site
101510018289	substrate binding site [chemical binding]; other site
101510018290	coenzyme B12 binding site [chemical binding]; other site
101510018291	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
101510018292	B12 binding site [chemical binding]; other site
101510018293	cobalt ligand [ion binding]; other site
101510018294	membrane ATPase/protein kinase; Provisional; Region: PRK09435
101510018295	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510018296	GTP/Mg2+ binding site [chemical binding]; other site
101510018297	G5 box; other site
101510018298	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
101510018299	Walker A; other site
101510018300	G1 box; other site
101510018301	Switch I region; other site
101510018302	G2 box; other site
101510018303	NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653
101510018304	active site
101510018305	OsmC-like protein; Region: OsmC; cl00767
101510018306	DinB superfamily; Region: DinB_2; cl00986
101510018307	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
101510018308	CoA-transferase family III; Region: CoA_transf_3; pfam02515
101510018309	Domain of unknown function DUF21; Region: DUF21; pfam01595
101510018310	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
101510018311	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
101510018312	Domain of unknown function DUF21; Region: DUF21; pfam01595
101510018313	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
101510018314	Transporter associated domain; Region: CorC_HlyC; cl08393
101510018315	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
101510018316	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
101510018317	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
101510018318	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
101510018319	active site
101510018320	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
101510018321	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
101510018322	ATP binding site [chemical binding]; other site
101510018323	Mg++ binding site [ion binding]; other site
101510018324	motif III; other site
101510018325	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
101510018326	nucleotide binding region [chemical binding]; other site
101510018327	ATP-binding site [chemical binding]; other site
101510018328	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510018329	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
101510018330	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
101510018331	helicase 45; Provisional; Region: PTZ00424
101510018332	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
101510018333	ATP binding site [chemical binding]; other site
101510018334	Mg++ binding site [ion binding]; other site
101510018335	motif III; other site
101510018336	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
101510018337	nucleotide binding region [chemical binding]; other site
101510018338	ATP-binding site [chemical binding]; other site
101510018339	Peptidase family M48; Region: Peptidase_M48; cl12018
101510018340	Helix-turn-helix domains; Region: HTH; cl00088
101510018341	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
101510018342	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
101510018343	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
101510018344	Walker A/P-loop; other site
101510018345	ATP binding site [chemical binding]; other site
101510018346	Q-loop/lid; other site
101510018347	ABC transporter signature motif; other site
101510018348	Walker B; other site
101510018349	D-loop; other site
101510018350	H-loop/switch region; other site
101510018351	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
101510018352	ABC-ATPase subunit  interface; other site
101510018353	dimer interface [polypeptide binding]; other site
101510018354	putative PBP binding regions; other site
101510018355	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
101510018356	dimer interface [polypeptide binding]; other site
101510018357	putative PBP binding regions; other site
101510018358	ABC-ATPase subunit  interface; other site
101510018359	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
101510018360	CoenzymeA binding site [chemical binding]; other site
101510018361	subunit interaction site [polypeptide binding]; other site
101510018362	PHB binding site; other site
101510018363	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
101510018364	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510018365	Transposase IS200 like; Region: Y1_Tnp; cl00848
101510018366	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
101510018367	Probable transposase; Region: OrfB_IS605; pfam01385
101510018368	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
101510018369	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
101510018370	AzlC protein; Region: AzlC; cl00570
101510018371	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
101510018372	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
101510018373	non-specific DNA binding site [nucleotide binding]; other site
101510018374	salt bridge; other site
101510018375	sequence-specific DNA binding site [nucleotide binding]; other site
101510018376	Cupin domain; Region: Cupin_2; cl09118
101510018377	YCII-related domain; Region: YCII; cl00999
101510018378	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
101510018379	Fic family protein [Function unknown]; Region: COG3177
101510018380	Fic/DOC family; Region: Fic; cl00960
101510018381	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
101510018382	ABC-ATPase subunit  interface; other site
101510018383	dimer interface [polypeptide binding]; other site
101510018384	putative PBP binding regions; other site
101510018385	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
101510018386	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235
101510018387	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
101510018388	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
101510018389	metal binding site [ion binding]; metal-binding site
101510018390	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
101510018391	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510018392	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510018393	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
101510018394	Helix-turn-helix domains; Region: HTH; cl00088
101510018395	cell division control protein 6; Reviewed; Region: cdc6; PRK00411
101510018396	Integrase core domain; Region: rve; cl01316
101510018397	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
101510018398	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
101510018399	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
101510018400	classical (c) SDRs; Region: SDR_c; cd05233
101510018401	NAD(P) binding site [chemical binding]; other site
101510018402	active site
101510018403	Fic family protein [Function unknown]; Region: COG3177
101510018404	PemK-like protein; Region: PemK; cl00995
101510018405	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
101510018406	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
101510018407	dimerization interface [polypeptide binding]; other site
101510018408	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
101510018409	dimer interface [polypeptide binding]; other site
101510018410	phosphorylation site [posttranslational modification]
101510018411	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510018412	ATP binding site [chemical binding]; other site
101510018413	Mg2+ binding site [ion binding]; other site
101510018414	G-X-G motif; other site
101510018415	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
101510018416	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510018417	active site
101510018418	phosphorylation site [posttranslational modification]
101510018419	intermolecular recognition site; other site
101510018420	dimerization interface [polypeptide binding]; other site
101510018421	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
101510018422	DNA binding site [nucleotide binding]
101510018423	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510018424	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
101510018425	TIGR03118 family protein; Region: PEPCTERM_chp_1
101510018426	AMP-binding enzyme; Region: AMP-binding; pfam00501
101510018427	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
101510018428	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510018429	NAD binding site [chemical binding]; other site
101510018430	catalytic residues [active]
101510018431	Integrase core domain; Region: rve; cl01316
101510018432	Helix-turn-helix domains; Region: HTH; cl00088
101510018433	Winged helix-turn helix; Region: HTH_29; pfam13551
101510018434	Helix-turn-helix domains; Region: HTH; cl00088
101510018435	Rhodopirellula transposase; Region: DDE_Tnp_ISAZ013; pfam07592
101510018436	Rhodopirellula transposase; Region: DDE_Tnp_ISAZ013; pfam07592
101510018437	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
101510018438	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
101510018439	putative active site [active]
101510018440	putative NTP binding site [chemical binding]; other site
101510018441	putative nucleic acid binding site [nucleotide binding]; other site
101510018442	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
101510018443	Rhodopirellula transposase; Region: DDE_Tnp_ISAZ013; pfam07592
101510018444	Transposase, Mutator family; Region: Transposase_mut; pfam00872
101510018445	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510018446	Helix-turn-helix domains; Region: HTH; cl00088
101510018447	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510018448	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346
101510018449	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
101510018450	putative active site [active]
101510018451	ATP binding site [chemical binding]; other site
101510018452	Phosphotransferase enzyme family; Region: APH; pfam01636
101510018453	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
101510018454	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
101510018455	FMN-binding pocket [chemical binding]; other site
101510018456	flavin binding motif; other site
101510018457	phosphate binding motif [ion binding]; other site
101510018458	beta-alpha-beta structure motif; other site
101510018459	NAD binding pocket [chemical binding]; other site
101510018460	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510018461	catalytic loop [active]
101510018462	iron binding site [ion binding]; other site
101510018463	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510018464	substrate binding site [chemical binding]; other site
101510018465	oxyanion hole (OAH) forming residues; other site
101510018466	trimer interface [polypeptide binding]; other site
101510018467	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
101510018468	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
101510018469	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
101510018470	homoserine O-acetyltransferase; Provisional; Region: metX; cl15472
101510018471	Transposase, Mutator family; Region: Transposase_mut; pfam00872
101510018472	Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253
101510018473	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
101510018474	NAD(P) binding site [chemical binding]; other site
101510018475	Domain of unknown function (DUF427); Region: DUF427; cl00998
101510018476	Domain of unknown function (DUF427); Region: DUF427; cl00998
101510018477	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510018478	substrate binding site [chemical binding]; other site
101510018479	oxyanion hole (OAH) forming residues; other site
101510018480	trimer interface [polypeptide binding]; other site
101510018481	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510018482	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
101510018483	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
101510018484	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510018485	active site
101510018486	phosphorylation site [posttranslational modification]
101510018487	intermolecular recognition site; other site
101510018488	dimerization interface [polypeptide binding]; other site
101510018489	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510018490	DNA binding residues [nucleotide binding]
101510018491	dimerization interface [polypeptide binding]; other site
101510018492	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
101510018493	active site
101510018494	ATP binding site [chemical binding]; other site
101510018495	substrate binding site [chemical binding]; other site
101510018496	activation loop (A-loop); other site
101510018497	Predicted ATPase [General function prediction only]; Region: COG3899
101510018498	Histidine kinase; Region: HisKA_3; pfam07730
101510018499	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510018500	ATP binding site [chemical binding]; other site
101510018501	Mg2+ binding site [ion binding]; other site
101510018502	G-X-G motif; other site
101510018503	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
101510018504	cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348
101510018505	NAD binding site [chemical binding]; other site
101510018506	active site
101510018507	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
101510018508	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
101510018509	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
101510018510	active site
101510018511	Fe binding site [ion binding]; other site
101510018512	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
101510018513	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510018514	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
101510018515	[2Fe-2S] cluster binding site [ion binding]; other site
101510018516	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
101510018517	inter-subunit interface; other site
101510018518	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
101510018519	Rieske non-heme iron oxygenase (RO) family, Biphenyl dioxygenase (BPDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of BPDO and similar proteins including cumene dioxygenase (CumDO); Region: Rieske_RO_Alpha_BPDO_like; cd03472
101510018520	beta subunit interaction site [polypeptide binding]; other site
101510018521	alpha subunit interaction site [polypeptide binding]; other site
101510018522	iron-sulfur cluster [ion binding]; other site
101510018523	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
101510018524	beta subunit interface [polypeptide binding]; other site
101510018525	alpha subunit interface [polypeptide binding]; other site
101510018526	active site
101510018527	substrate binding site [chemical binding]; other site
101510018528	Fe binding site [ion binding]; other site
101510018529	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
101510018530	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510018531	ATP binding site [chemical binding]; other site
101510018532	Mg2+ binding site [ion binding]; other site
101510018533	G-X-G motif; other site
101510018534	Helix-turn-helix domain; Region: HTH_18; pfam12833
101510018535	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510018536	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
101510018537	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510018538	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
101510018539	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
101510018540	FMN-binding pocket [chemical binding]; other site
101510018541	flavin binding motif; other site
101510018542	phosphate binding motif [ion binding]; other site
101510018543	beta-alpha-beta structure motif; other site
101510018544	NAD binding pocket [chemical binding]; other site
101510018545	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510018546	catalytic loop [active]
101510018547	iron binding site [ion binding]; other site
101510018548	Cytochrome P450; Region: p450; cl12078
101510018549	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl01383
101510018550	chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465
101510018551	active site
101510018552	EthD protein; Region: EthD; cl06234
101510018553	Chlorite dismutase; Region: Chlor_dismutase; cl01280
101510018554	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510018555	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510018556	active site
101510018557	ATP binding site [chemical binding]; other site
101510018558	substrate binding site [chemical binding]; other site
101510018559	activation loop (A-loop); other site
101510018560	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
101510018561	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
101510018562	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510018563	Flavin Reductases; Region: FlaRed; cl00801
101510018564	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310
101510018565	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
101510018566	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510018567	catalytic loop [active]
101510018568	iron binding site [ion binding]; other site
101510018569	N-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_N; cd07265
101510018570	catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211
101510018571	tetramer interface [polypeptide binding]; other site
101510018572	C-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_C; cd07243
101510018573	tetramer interface [polypeptide binding]; other site
101510018574	active site
101510018575	Fe binding site [ion binding]; other site
101510018576	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
101510018577	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
101510018578	homoserine O-acetyltransferase; Provisional; Region: metX; cl15472
101510018579	Transcription factor WhiB; Region: Whib; pfam02467
101510018580	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
101510018581	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
101510018582	active site
101510018583	catalytic residues [active]
101510018584	metal binding site [ion binding]; metal-binding site
101510018585	DmpG-like communication domain; Region: DmpG_comm; pfam07836
101510018586	acetaldehyde dehydrogenase; Validated; Region: PRK08300
101510018587	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510018588	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
101510018589	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
101510018590	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510018591	Helix-turn-helix domains; Region: HTH; cl00088
101510018592	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510018593	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
101510018594	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510018595	DNA binding residues [nucleotide binding]
101510018596	dimerization interface [polypeptide binding]; other site
101510018597	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
101510018598	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510018599	NAD(P) binding site [chemical binding]; other site
101510018600	catalytic residues [active]
101510018601	Cupin domain; Region: Cupin_2; cl09118
101510018602	Cupin domain; Region: Cupin_2; cl09118
101510018603	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
101510018604	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
101510018605	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510018606	DNA-binding site [nucleotide binding]; DNA binding site
101510018607	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
101510018608	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510018609	homodimer interface [polypeptide binding]; other site
101510018610	catalytic residue [active]
101510018611	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
101510018612	Cupin domain; Region: Cupin_2; cl09118
101510018613	Cupin domain; Region: Cupin_2; cl09118
101510018614	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
101510018615	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
101510018616	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510018617	Cupin domain; Region: Cupin_2; cl09118
101510018618	Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117
101510018619	homodimer interface [polypeptide binding]; other site
101510018620	putative active site [active]
101510018621	catalytic site [active]
101510018622	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510018623	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
101510018624	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510018625	DNA binding site [nucleotide binding]
101510018626	Int/Topo IB signature motif; other site
101510018627	active site
101510018628	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
101510018629	DNA binding residues [nucleotide binding]
101510018630	Lsr2; Region: Lsr2; pfam11774
101510018631	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
101510018632	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510018633	Uncharacterized conserved protein [Function unknown]; Region: COG3268
101510018634	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
101510018635	catalytic residue [active]
101510018636	Peptidase family M23; Region: Peptidase_M23; pfam01551
101510018637	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599
101510018638	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
101510018639	active site
101510018640	Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487
101510018641	active site
101510018642	catalytic triad [active]
101510018643	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
101510018644	active site
101510018645	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
101510018646	Secretory lipase; Region: LIP; pfam03583
101510018647	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510018648	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510018649	Helix-turn-helix domains; Region: HTH; cl00088
101510018650	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
101510018651	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510018652	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510018653	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510018654	active site
101510018655	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
101510018656	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510018657	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
101510018658	Strictosidine synthase; Region: Str_synth; pfam03088
101510018659	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
101510018660	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
101510018661	FMN binding site [chemical binding]; other site
101510018662	substrate binding site [chemical binding]; other site
101510018663	putative catalytic residue [active]
101510018664	enoyl-CoA hydratase; Provisional; Region: PRK08260
101510018665	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510018666	substrate binding site [chemical binding]; other site
101510018667	oxyanion hole (OAH) forming residues; other site
101510018668	trimer interface [polypeptide binding]; other site
101510018669	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
101510018670	Transposase; Region: DEDD_Tnp_IS110; pfam01548
101510018671	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510018672	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510018673	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
101510018674	dimer interface [polypeptide binding]; other site
101510018675	NADP binding site [chemical binding]; other site
101510018676	catalytic residues [active]
101510018677	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
101510018678	CoA-transferase family III; Region: CoA_transf_3; pfam02515
101510018679	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510018680	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510018681	active site
101510018682	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
101510018683	CoA-transferase family III; Region: CoA_transf_3; pfam02515
101510018684	Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231
101510018685	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
101510018686	catalytic Zn binding site [ion binding]; other site
101510018687	structural Zn binding site [ion binding]; other site
101510018688	tetramer interface [polypeptide binding]; other site
101510018689	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
101510018690	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
101510018691	Histidine kinase; Region: HisKA_3; pfam07730
101510018692	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
101510018693	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510018694	active site
101510018695	phosphorylation site [posttranslational modification]
101510018696	intermolecular recognition site; other site
101510018697	dimerization interface [polypeptide binding]; other site
101510018698	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510018699	DNA binding residues [nucleotide binding]
101510018700	dimerization interface [polypeptide binding]; other site
101510018701	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510018702	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510018703	putative substrate translocation pore; other site
101510018704	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
101510018705	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
101510018706	intersubunit interface [polypeptide binding]; other site
101510018707	active site
101510018708	Zn2+ binding site [ion binding]; other site
101510018709	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
101510018710	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510018711	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510018712	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510018713	NAD(P) binding site [chemical binding]; other site
101510018714	active site
101510018715	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
101510018716	inter-subunit interface; other site
101510018717	Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535
101510018718	alpha subunit interaction site [polypeptide binding]; other site
101510018719	beta subunit interaction site [polypeptide binding]; other site
101510018720	iron-sulfur cluster [ion binding]; other site
101510018721	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
101510018722	beta subunit interface [polypeptide binding]; other site
101510018723	alpha subunit interface [polypeptide binding]; other site
101510018724	active site
101510018725	substrate binding site [chemical binding]; other site
101510018726	Fe binding site [ion binding]; other site
101510018727	Helix-turn-helix domains; Region: HTH; cl00088
101510018728	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510018729	Isochorismatase family; Region: Isochorismatase; pfam00857
101510018730	N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015
101510018731	substrate binding site [chemical binding]; other site
101510018732	catalytic triad [active]
101510018733	domain interfaces; other site
101510018734	conserved cis-peptide bond; other site
101510018735	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510018736	dimer interface [polypeptide binding]; other site
101510018737	conserved gate region; other site
101510018738	putative PBP binding loops; other site
101510018739	ABC-ATPase subunit interface; other site
101510018740	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510018741	dimer interface [polypeptide binding]; other site
101510018742	conserved gate region; other site
101510018743	putative PBP binding loops; other site
101510018744	ABC-ATPase subunit interface; other site
101510018745	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
101510018746	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
101510018747	Walker A/P-loop; other site
101510018748	ATP binding site [chemical binding]; other site
101510018749	Q-loop/lid; other site
101510018750	ABC transporter signature motif; other site
101510018751	Walker B; other site
101510018752	D-loop; other site
101510018753	H-loop/switch region; other site
101510018754	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
101510018755	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
101510018756	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
101510018757	Helix-turn-helix domains; Region: HTH; cl00088
101510018758	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510018759	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
101510018760	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
101510018761	iron-sulfur cluster [ion binding]; other site
101510018762	[2Fe-2S] cluster binding site [ion binding]; other site
101510018763	C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880
101510018764	putative alpha subunit interface [polypeptide binding]; other site
101510018765	putative active site [active]
101510018766	putative substrate binding site [chemical binding]; other site
101510018767	Fe binding site [ion binding]; other site
101510018768	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
101510018769	inter-subunit interface; other site
101510018770	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
101510018771	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
101510018772	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
101510018773	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510018774	catalytic loop [active]
101510018775	iron binding site [ion binding]; other site
101510018776	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
101510018777	FAD binding pocket [chemical binding]; other site
101510018778	FAD binding motif [chemical binding]; other site
101510018779	phosphate binding motif [ion binding]; other site
101510018780	beta-alpha-beta structure motif; other site
101510018781	NAD binding pocket [chemical binding]; other site
101510018782	benzoate transport; Region: 2A0115; TIGR00895
101510018783	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510018784	putative substrate translocation pore; other site
101510018785	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
101510018786	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
101510018787	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
101510018788	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
101510018789	Integrase core domain; Region: rve; cl01316
101510018790	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
101510018791	homoserine O-acetyltransferase; Provisional; Region: metX; cl15472
101510018792	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
101510018793	EthD protein; Region: EthD; cl06234
101510018794	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
101510018795	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510018796	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
101510018797	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
101510018798	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
101510018799	Helix-turn-helix domains; Region: HTH; cl00088
101510018800	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
101510018801	active site
101510018802	NTP binding site [chemical binding]; other site
101510018803	metal binding triad [ion binding]; metal-binding site
101510018804	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
101510018805	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510018806	Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077
101510018807	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
101510018808	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510018809	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
101510018810	Excalibur calcium-binding domain; Region: Excalibur; cl05460
101510018811	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
101510018812	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
101510018813	putative metal binding site [ion binding]; other site
101510018814	Integral membrane protein TerC family; Region: TerC; cl10468
101510018815	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
101510018816	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
101510018817	Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110
101510018818	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
101510018819	putative metal binding site [ion binding]; other site
101510018820	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
101510018821	TM-ABC transporter signature motif; other site
101510018822	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
101510018823	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
101510018824	Walker A/P-loop; other site
101510018825	ATP binding site [chemical binding]; other site
101510018826	Q-loop/lid; other site
101510018827	ABC transporter signature motif; other site
101510018828	Walker B; other site
101510018829	D-loop; other site
101510018830	H-loop/switch region; other site
101510018831	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
101510018832	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_7; cd06316
101510018833	putative ligand binding site [chemical binding]; other site
101510018834	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
101510018835	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510018836	NAD binding site [chemical binding]; other site
101510018837	catalytic residues [active]
101510018838	Helix-turn-helix domains; Region: HTH; cl00088
101510018839	DNA-binding site [nucleotide binding]; DNA binding site
101510018840	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
101510018841	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
101510018842	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
101510018843	classical (c) SDRs; Region: SDR_c; cd05233
101510018844	NAD(P) binding site [chemical binding]; other site
101510018845	active site
101510018846	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510018847	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510018848	putative substrate translocation pore; other site
101510018849	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
101510018850	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510018851	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
101510018852	Uncharacterised protein family (UPF0261); Region: UPF0261; cl02262
101510018853	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510018854	classical (c) SDRs; Region: SDR_c; cd05233
101510018855	NAD(P) binding site [chemical binding]; other site
101510018856	active site
101510018857	TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424
101510018858	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973
101510018859	Predicted transcriptional regulator [Transcription]; Region: COG5340
101510018860	Uncharacterised protein family (UPF0242); Region: UPF0242; pfam06785
101510018861	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
101510018862	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
101510018863	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
101510018864	Domain of unknown function (DUF1994); Region: DUF1994; cl09179
101510018865	Lsr2; Region: Lsr2; pfam11774
101510018866	Lsr2; Region: Lsr2; pfam11774
101510018867	Lsr2; Region: Lsr2; pfam11774
101510018868	Lsr2; Region: Lsr2; pfam11774
101510018869	Transcription factor WhiB; Region: Whib; pfam02467
101510018870	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
101510018871	Transposase; Region: DDE_Tnp_ISL3; pfam01610
101510018872	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510018873	putative substrate translocation pore; other site
101510018874	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
101510018875	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
101510018876	FOG: CBS domain [General function prediction only]; Region: COG0517
101510018877	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
101510018878	BON domain; Region: BON; cl02771
101510018879	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
101510018880	Ferritin-like domain; Region: Ferritin; pfam00210
101510018881	dimerization interface [polypeptide binding]; other site
101510018882	DPS ferroxidase diiron center [ion binding]; other site
101510018883	ion pore; other site
101510018884	Transcription factor WhiB; Region: Whib; pfam02467
101510018885	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
101510018886	ligand binding site [chemical binding]; other site
101510018887	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
101510018888	phosphopeptide binding site; other site
101510018889	Predicted transcriptional regulator [Transcription]; Region: COG2345
101510018890	Helix-turn-helix domains; Region: HTH; cl00088
101510018891	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
101510018892	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
101510018893	tetramer interface [polypeptide binding]; other site
101510018894	heme binding pocket [chemical binding]; other site
101510018895	NADPH binding site [chemical binding]; other site
101510018896	YCII-related domain; Region: YCII; cl00999
101510018897	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
101510018898	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510018899	active site
101510018900	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
101510018901	aconitate hydratase; Validated; Region: PRK09277
101510018902	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
101510018903	substrate binding site [chemical binding]; other site
101510018904	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
101510018905	ligand binding site [chemical binding]; other site
101510018906	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
101510018907	substrate binding site [chemical binding]; other site
101510018908	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
101510018909	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
101510018910	Protein of unknown function, DUF488; Region: DUF488; cl01246
101510018911	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
101510018912	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
101510018913	DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100
101510018914	Helix-turn-helix domains; Region: HTH; cl00088
101510018915	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
101510018916	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
101510018917	active site
101510018918	FMN binding site [chemical binding]; other site
101510018919	substrate binding site [chemical binding]; other site
101510018920	3Fe-4S cluster binding site [ion binding]; other site
101510018921	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
101510018922	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510018923	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
101510018924	putative active site [active]
101510018925	transaldolase; Provisional; Region: PRK03903
101510018926	catalytic residue [active]
101510018927	Helix-turn-helix domains; Region: HTH; cl00088
101510018928	Predicted transcriptional regulator [Transcription]; Region: COG2345
101510018929	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
101510018930	GTP cyclohydrolase I; Provisional; Region: PLN03044
101510018931	active site
101510018932	Protein of unknown function, DUF488; Region: DUF488; cl01246
101510018933	Helix-turn-helix domains; Region: HTH; cl00088
101510018934	Predicted transcriptional regulator [Transcription]; Region: COG2345
101510018935	Ferredoxin [Energy production and conversion]; Region: COG1146
101510018936	4Fe-4S binding domain; Region: Fer4; cl02805
101510018937	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
101510018938	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
101510018939	D-pathway; other site
101510018940	Putative ubiquinol binding site [chemical binding]; other site
101510018941	Low-spin heme (heme b) binding site [chemical binding]; other site
101510018942	Putative water exit pathway; other site
101510018943	Binuclear center (heme o3/CuB) [ion binding]; other site
101510018944	K-pathway; other site
101510018945	Putative proton exit pathway; other site
101510018946	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
101510018947	heme-binding site [chemical binding]; other site
101510018948	Protein of unknown function (DUF952); Region: DUF952; cl01393
101510018949	Helix-turn-helix domains; Region: HTH; cl00088
101510018950	Predicted transcriptional regulator [Transcription]; Region: COG2345
101510018951	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
101510018952	synthetase active site [active]
101510018953	NTP binding site [chemical binding]; other site
101510018954	metal binding site [ion binding]; metal-binding site
101510018955	Helix-turn-helix domains; Region: HTH; cl00088
101510018956	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
101510018957	active site clefts [active]
101510018958	zinc binding site [ion binding]; other site
101510018959	dimer interface [polypeptide binding]; other site
101510018960	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
101510018961	Transposase, Mutator family; Region: Transposase_mut; pfam00872
101510018962	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
101510018963	Integrase core domain; Region: rve; cl01316
101510018964	Transposase, Mutator family; Region: Transposase_mut; pfam00872
101510018965	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510018966	DNA binding site [nucleotide binding]
101510018967	Int/Topo IB signature motif; other site
101510018968	active site
101510018969	Helix-turn-helix domains; Region: HTH; cl00088
101510018970	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510018971	active site
101510018972	Int/Topo IB signature motif; other site
101510018973	DNA binding site [nucleotide binding]
101510018974	Transposase, Mutator family; Region: Transposase_mut; pfam00872
101510018975	MULE transposase domain; Region: MULE; pfam10551
101510018976	YCII-related domain; Region: YCII; cl00999
101510018977	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
101510018978	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
101510018979	active site
101510018980	FMN binding site [chemical binding]; other site
101510018981	substrate binding site [chemical binding]; other site
101510018982	3Fe-4S cluster binding site [ion binding]; other site
101510018983	Helix-turn-helix domains; Region: HTH; cl00088
101510018984	short chain dehydrogenase; Provisional; Region: PRK07109
101510018985	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
101510018986	putative NAD(P) binding site [chemical binding]; other site
101510018987	active site
101510018988	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
101510018989	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
101510018990	thiamine pyrophosphate protein; Provisional; Region: PRK08273
101510018991	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
101510018992	PYR/PP interface [polypeptide binding]; other site
101510018993	tetramer interface [polypeptide binding]; other site
101510018994	dimer interface [polypeptide binding]; other site
101510018995	TPP binding site [chemical binding]; other site
101510018996	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
101510018997	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
101510018998	TPP-binding site [chemical binding]; other site
101510018999	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328
101510019000	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
101510019001	putative active site pocket [active]
101510019002	putative metal binding site [ion binding]; other site
101510019003	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
101510019004	FAD binding domain; Region: FAD_binding_4; pfam01565
101510019005	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
101510019006	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
101510019007	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510019008	Protein of unknown function (DUF998); Region: DUF998; pfam06197
101510019009	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
101510019010	Integrase core domain; Region: rve; cl01316
101510019011	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
101510019012	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
101510019013	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
101510019014	catalytic residue [active]
101510019015	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
101510019016	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
101510019017	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
101510019018	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
101510019019	nucleophile elbow; other site
101510019020	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
101510019021	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
101510019022	Transposase; Region: DEDD_Tnp_IS110; pfam01548
101510019023	Domain of unknown function (DUF1931); Region: DUF1931; pfam09123
101510019024	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
101510019025	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
101510019026	PhoU domain; Region: PhoU; pfam01895
101510019027	PhoU domain; Region: PhoU; pfam01895
101510019028	Protein of unknown function, DUF488; Region: DUF488; cl01246
101510019029	Helix-turn-helix domains; Region: HTH; cl00088
101510019030	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
101510019031	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
101510019032	anti sigma factor interaction site; other site
101510019033	regulatory phosphorylation site [posttranslational modification]; other site
101510019034	GAF domain; Region: GAF; cl00853
101510019035	ANTAR domain; Region: ANTAR; cl04297
101510019036	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
101510019037	HSP70 interaction site [polypeptide binding]; other site
101510019038	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
101510019039	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
101510019040	putative dimer interface [polypeptide binding]; other site
101510019041	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
101510019042	DNA binding residues [nucleotide binding]
101510019043	putative dimer interface [polypeptide binding]; other site
101510019044	Transcription factor WhiB; Region: Whib; pfam02467
101510019045	Protein of unknown function (DUF3184); Region: DUF3184; pfam11380
101510019046	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
101510019047	Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314
101510019048	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
101510019049	putative dimer interface [polypeptide binding]; other site
101510019050	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510019051	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510019052	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
101510019053	Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528
101510019054	ATP binding site [chemical binding]; other site
101510019055	profilin binding site; other site
101510019056	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
101510019057	dimer interface [polypeptide binding]; other site
101510019058	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
101510019059	chaperone protein DnaJ; Provisional; Region: PRK14279
101510019060	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
101510019061	HSP70 interaction site [polypeptide binding]; other site
101510019062	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
101510019063	Zn binding sites [ion binding]; other site
101510019064	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
101510019065	dimer interface [polypeptide binding]; other site
101510019066	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
101510019067	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
101510019068	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
101510019069	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
101510019070	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
101510019071	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
101510019072	Uncharacterised protein family (UPF0158); Region: UPF0158; pfam03682
101510019073	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510019074	NmrA-like family; Region: NmrA; pfam05368
101510019075	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
101510019076	NAD(P) binding site [chemical binding]; other site
101510019077	putative active site [active]
101510019078	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
101510019079	PemK-like protein; Region: PemK; cl00995
101510019080	Integrase core domain; Region: rve; cl01316
101510019081	Leucine carboxyl methyltransferase; Region: LCM; cl01306
101510019082	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
101510019083	Protein of unknown function (DUF1804); Region: DUF1804; pfam08822
101510019084	Integrase core domain; Region: rve; cl01316
101510019085	Transposase; Region: DEDD_Tnp_IS110; pfam01548
101510019086	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
101510019087	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510019088	ANTAR domain; Region: ANTAR; cl04297
101510019089	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cl00891
101510019090	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
101510019091	N-formylglutamate amidohydrolase; Region: FGase; cl01522
101510019092	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
101510019093	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
101510019094	catalytic residue [active]
101510019095	Peptidase family M23; Region: Peptidase_M23; pfam01551
101510019096	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599
101510019097	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
101510019098	active site
101510019099	Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487
101510019100	active site
101510019101	catalytic triad [active]
101510019102	chaperone protein DnaJ; Provisional; Region: PRK14279
101510019103	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
101510019104	active site
101510019105	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
101510019106	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
101510019107	Secretory lipase; Region: LIP; pfam03583
101510019108	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510019109	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510019110	Helix-turn-helix domains; Region: HTH; cl00088
101510019111	ANTAR domain; Region: ANTAR; cl04297
101510019112	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
101510019113	catalytic core [active]
101510019114	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
101510019115	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510019116	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510019117	DNA binding residues [nucleotide binding]
101510019118	dimerization interface [polypeptide binding]; other site
101510019119	Transposase, Mutator family; Region: Transposase_mut; pfam00872
101510019120	MULE transposase domain; Region: MULE; pfam10551
101510019121	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510019122	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
101510019123	Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253
101510019124	NAD(P) binding site [chemical binding]; other site
101510019125	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510019126	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510019127	active site
101510019128	crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155
101510019129	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510019130	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
101510019131	TM-ABC transporter signature motif; other site
101510019132	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
101510019133	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
101510019134	Walker A/P-loop; other site
101510019135	ATP binding site [chemical binding]; other site
101510019136	Q-loop/lid; other site
101510019137	ABC transporter signature motif; other site
101510019138	Walker B; other site
101510019139	D-loop; other site
101510019140	H-loop/switch region; other site
101510019141	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
101510019142	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
101510019143	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
101510019144	Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177
101510019145	active site
101510019146	dimer interface [polypeptide binding]; other site
101510019147	metal binding site [ion binding]; metal-binding site
101510019148	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510019149	Helix-turn-helix domains; Region: HTH; cl00088
101510019150	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
101510019151	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
101510019152	NAD(P) binding site [chemical binding]; other site
101510019153	Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173
101510019154	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
101510019155	putative active site [active]
101510019156	putative substrate binding site [chemical binding]; other site
101510019157	ATP binding site [chemical binding]; other site
101510019158	enoyl-CoA hydratase; Region: PLN02864
101510019159	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
101510019160	active site
101510019161	catalytic site [active]
101510019162	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
101510019163	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510019164	NAD(P) binding site [chemical binding]; other site
101510019165	active site
101510019166	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
101510019167	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
101510019168	NAD binding site [chemical binding]; other site
101510019169	homotetramer interface [polypeptide binding]; other site
101510019170	homodimer interface [polypeptide binding]; other site
101510019171	active site
101510019172	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
101510019173	Citrate synthase; Region: Citrate_synt; pfam00285
101510019174	oxalacetate binding site [chemical binding]; other site
101510019175	citrylCoA binding site [chemical binding]; other site
101510019176	coenzyme A binding site [chemical binding]; other site
101510019177	catalytic triad [active]
101510019178	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
101510019179	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
101510019180	acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910
101510019181	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895
101510019182	metal binding site [ion binding]; metal-binding site
101510019183	dimer interface [polypeptide binding]; other site
101510019184	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510019185	acyl-CoA synthetase; Validated; Region: PRK08162
101510019186	Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003
101510019187	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
101510019188	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
101510019189	catalytic residue [active]
101510019190	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
101510019191	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
101510019192	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
101510019193	catalytic residue [active]
101510019194	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
101510019195	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510019196	classical (c) SDRs; Region: SDR_c; cd05233
101510019197	NAD(P) binding site [chemical binding]; other site
101510019198	active site
101510019199	Amino acid permease; Region: AA_permease; cl00524
101510019200	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
101510019201	Helix-turn-helix domains; Region: HTH; cl00088
101510019202	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
101510019203	dimerization interface [polypeptide binding]; other site
101510019204	substrate binding pocket [chemical binding]; other site
101510019205	ethanolamine permease; Region: 2A0305; TIGR00908
101510019206	Amino acid permease; Region: AA_permease; cl00524
101510019207	tyramine oxidase; Provisional; Region: tynA; PRK11504
101510019208	Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727
101510019209	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
101510019210	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
101510019211	Amino acid permease; Region: AA_permease; cl00524
101510019212	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510019213	Helix-turn-helix domains; Region: HTH; cl00088
101510019214	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510019215	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
101510019216	Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15375
101510019217	Protein of unknown function (DUF1016); Region: DUF1016; cl01979
101510019218	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510019219	Phage integrase family; Region: Phage_integrase; pfam00589
101510019220	DNA binding site [nucleotide binding]
101510019221	Int/Topo IB signature motif; other site
101510019222	active site
101510019223	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510019224	Phage integrase family; Region: Phage_integrase; pfam00589
101510019225	DNA binding site [nucleotide binding]
101510019226	Int/Topo IB signature motif; other site
101510019227	active site
101510019228	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
101510019229	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510019230	DNA binding site [nucleotide binding]
101510019231	Int/Topo IB signature motif; other site
101510019232	active site
101510019233	Transposase, Mutator family; Region: Transposase_mut; pfam00872
101510019234	MULE transposase domain; Region: MULE; pfam10551
101510019235	Protein of unknown function (DUF1016); Region: DUF1016; cl01979
101510019236	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
101510019237	DNA binding residues [nucleotide binding]
101510019238	Helicase associated domain; Region: HA; pfam03457
101510019239	Helicase associated domain; Region: HA; pfam03457
101510019240	Domain of unknown function (DUF1994); Region: DUF1994; cl09179
101510019241	Integrase core domain; Region: rve; cl01316
101510019242	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
101510019243	Transposase domain (DUF772); Region: DUF772; cl12084
101510019244	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
101510019245	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
101510019246	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
101510019247	DNA binding site [nucleotide binding]
101510019248	Uncharacterised ACR, COG2135; Region: DUF159; cl03646
101510019249	Lsr2; Region: Lsr2; pfam11774
101510019250	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
101510019251	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510019252	classical (c) SDRs; Region: SDR_c; cd05233
101510019253	NAD(P) binding site [chemical binding]; other site
101510019254	active site
101510019255	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_8; cd06317
101510019256	putative ligand binding site [chemical binding]; other site
101510019257	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
101510019258	TM-ABC transporter signature motif; other site
101510019259	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
101510019260	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
101510019261	TM-ABC transporter signature motif; other site
101510019262	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
101510019263	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
101510019264	Walker A/P-loop; other site
101510019265	ATP binding site [chemical binding]; other site
101510019266	Q-loop/lid; other site
101510019267	ABC transporter signature motif; other site
101510019268	Walker B; other site
101510019269	D-loop; other site
101510019270	H-loop/switch region; other site
101510019271	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
101510019272	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510019273	classical (c) SDRs; Region: SDR_c; cd05233
101510019274	NAD(P) binding site [chemical binding]; other site
101510019275	active site
101510019276	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510019277	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
101510019278	Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177
101510019279	active site
101510019280	dimer interface [polypeptide binding]; other site
101510019281	metal binding site [ion binding]; metal-binding site
101510019282	Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461
101510019283	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
101510019284	dimer interface [polypeptide binding]; other site
101510019285	active site
101510019286	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
101510019287	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510019288	NAD(P) binding site [chemical binding]; other site
101510019289	active site
101510019290	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
101510019291	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
101510019292	non-specific DNA binding site [nucleotide binding]; other site
101510019293	salt bridge; other site
101510019294	sequence-specific DNA binding site [nucleotide binding]; other site
101510019295	Cupin domain; Region: Cupin_2; cl09118
101510019296	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
101510019297	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
101510019298	Protein of unknown function (DUF3018); Region: DUF3018; pfam11455
101510019299	PemK-like protein; Region: PemK; cl00995
101510019300	NmrA-like family; Region: NmrA; pfam05368
101510019301	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
101510019302	NAD(P) binding site [chemical binding]; other site
101510019303	putative active site [active]
101510019304	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510019305	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
101510019306	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
101510019307	catalytic residues [active]
101510019308	catalytic nucleophile [active]
101510019309	Presynaptic Site I dimer interface [polypeptide binding]; other site
101510019310	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
101510019311	Synaptic Flat tetramer interface [polypeptide binding]; other site
101510019312	Synaptic Site I dimer interface [polypeptide binding]; other site
101510019313	DNA binding site [nucleotide binding]
101510019314	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358
101510019315	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
101510019316	transposase; Provisional; Region: PRK06526
101510019317	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510019318	Helix-turn-helix domains; Region: HTH; cl00088
101510019319	DNA-binding site [nucleotide binding]; DNA binding site
101510019320	Integrase core domain; Region: rve; cl01316
101510019321	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
101510019322	Integrase core domain; Region: rve; cl01316
101510019323	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
101510019324	Helix-turn-helix domains; Region: HTH; cl00088
101510019325	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
101510019326	active site
101510019327	FMN binding site [chemical binding]; other site
101510019328	substrate binding site [chemical binding]; other site
101510019329	putative catalytic residue [active]
101510019330	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
101510019331	active site
101510019332	catalytic site [active]
101510019333	NHL repeat; Region: NHL; pfam01436
101510019334	NHL repeat; Region: NHL; pfam01436
101510019335	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
101510019336	phosphopeptide binding site; other site
101510019337	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
101510019338	phosphopeptide binding site; other site
101510019339	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
101510019340	ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR).  DR is a well-described phenomenon occurring in fungi and shares several similarities with processes...; Region: ABCG_EPDR; cd03213
101510019341	Walker A/P-loop; other site
101510019342	ATP binding site [chemical binding]; other site
101510019343	Q-loop/lid; other site
101510019344	ABC transporter signature motif; other site
101510019345	Walker B; other site
101510019346	D-loop; other site
101510019347	H-loop/switch region; other site
101510019348	ABC-2 type transporter; Region: ABC2_membrane; cl11417
101510019349	Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221
101510019350	acyl-CoA binding pocket [chemical binding]; other site
101510019351	CoA binding site [chemical binding]; other site
101510019352	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510019353	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510019354	active site
101510019355	ATP binding site [chemical binding]; other site
101510019356	substrate binding site [chemical binding]; other site
101510019357	activation loop (A-loop); other site
101510019358	NHL repeat; Region: NHL; pfam01436
101510019359	Uncharacterized conserved protein [Function unknown]; Region: COG3391
101510019360	NHL repeat; Region: NHL; pfam01436
101510019361	NHL repeat; Region: NHL; pfam01436
101510019362	NHL repeat; Region: NHL; pfam01436
101510019363	putative transposase OrfB; Reviewed; Region: PHA02517
101510019364	Integrase core domain; Region: rve; cl01316
101510019365	Helix-turn-helix domains; Region: HTH; cl00088
101510019366	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
101510019367	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
101510019368	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
101510019369	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
101510019370	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510019371	dimer interface [polypeptide binding]; other site
101510019372	conserved gate region; other site
101510019373	putative PBP binding loops; other site
101510019374	ABC-ATPase subunit interface; other site
101510019375	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
101510019376	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510019377	Walker A/P-loop; other site
101510019378	ATP binding site [chemical binding]; other site
101510019379	Q-loop/lid; other site
101510019380	ABC transporter signature motif; other site
101510019381	Walker B; other site
101510019382	D-loop; other site
101510019383	H-loop/switch region; other site
101510019384	TOBE domain; Region: TOBE_2; cl01440
101510019385	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510019386	S-adenosylmethionine binding site [chemical binding]; other site
101510019387	Condensation domain; Region: Condensation; pfam00668
101510019388	peptide synthase; Provisional; Region: PRK12467
101510019389	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510019390	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510019391	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
101510019392	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510019393	active site
101510019394	phosphorylation site [posttranslational modification]
101510019395	intermolecular recognition site; other site
101510019396	dimerization interface [polypeptide binding]; other site
101510019397	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
101510019398	DNA binding site [nucleotide binding]
101510019399	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
101510019400	dimerization interface [polypeptide binding]; other site
101510019401	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
101510019402	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510019403	ATP binding site [chemical binding]; other site
101510019404	Mg2+ binding site [ion binding]; other site
101510019405	G-X-G motif; other site
101510019406	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
101510019407	active site
101510019408	catalytic triad [active]
101510019409	oxyanion hole [active]
101510019410	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
101510019411	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
101510019412	active site
101510019413	Interferon-induced transmembrane protein; Region: CD225; pfam04505
101510019414	hypothetical protein; Provisional; Region: PRK13685
101510019415	Aerotolerance regulator N-terminal; Region: BatA; cl06567
101510019416	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
101510019417	metal ion-dependent adhesion site (MIDAS); other site
101510019418	Putative esterase; Region: Esterase; pfam00756
101510019419	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
101510019420	NodB motif; other site
101510019421	active site
101510019422	catalytic site [active]
101510019423	metal binding site [ion binding]; metal-binding site
101510019424	MspA; Region: MspA; pfam09203
101510019425	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
101510019426	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
101510019427	Walker A/P-loop; other site
101510019428	ATP binding site [chemical binding]; other site
101510019429	Q-loop/lid; other site
101510019430	ABC transporter signature motif; other site
101510019431	Walker B; other site
101510019432	D-loop; other site
101510019433	H-loop/switch region; other site
101510019434	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
101510019435	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
101510019436	Walker A/P-loop; other site
101510019437	ATP binding site [chemical binding]; other site
101510019438	Q-loop/lid; other site
101510019439	ABC transporter signature motif; other site
101510019440	Walker B; other site
101510019441	D-loop; other site
101510019442	H-loop/switch region; other site
101510019443	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
101510019444	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
101510019445	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
101510019446	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
101510019447	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
101510019448	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
101510019449	Domain of unknown function DUF20; Region: UPF0118; cl00465
101510019450	Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918
101510019451	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
101510019452	active site
101510019453	catalytic site [active]
101510019454	DinB superfamily; Region: DinB_2; cl00986
101510019455	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510019456	DNA binding residues [nucleotide binding]
101510019457	dimerization interface [polypeptide binding]; other site
101510019458	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
101510019459	RNB domain; Region: RNB; pfam00773
101510019460	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
101510019461	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
101510019462	RNA-binding motif; other site
101510019463	DNA-binding site [nucleotide binding]; DNA binding site
101510019464	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
101510019465	Transposase domain (DUF772); Region: DUF772; cl12084
101510019466	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
101510019467	Integrase core domain; Region: rve; cl01316
101510019468	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
101510019469	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510019470	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
101510019471	Transposase, Mutator family; Region: Transposase_mut; pfam00872
101510019472	MULE transposase domain; Region: MULE; pfam10551
101510019473	ParB-like partition proteins; Region: parB_part; TIGR00180
101510019474	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
101510019475	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
101510019476	Integrase core domain; Region: rve; cl01316
101510019477	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
101510019478	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510019479	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
101510019480	Magnesium ion binding site [ion binding]; other site
101510019481	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510019482	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510019483	Helicase associated domain; Region: HA; pfam03457
101510019484	Helicase associated domain; Region: HA; pfam03457
101510019485	Lsr2; Region: Lsr2; pfam11774
101510019486	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
101510019487	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510019488	Helix-turn-helix domains; Region: HTH; cl00088
101510019489	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
101510019490	RNB domain; Region: RNB; pfam00773
101510019491	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
101510019492	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
101510019493	dsRNA binding site [nucleotide binding]; other site
101510019494	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
101510019495	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510019496	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
101510019497	DNA-binding site [nucleotide binding]; DNA binding site
101510019498	RNA-binding motif; other site
101510019499	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
101510019500	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
101510019501	inhibitor-cofactor binding pocket; inhibition site
101510019502	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510019503	catalytic residue [active]
101510019504	acetylornithine deacetylase; Validated; Region: PRK06915
101510019505	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
101510019506	metal binding site [ion binding]; metal-binding site
101510019507	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510019508	Helix-turn-helix domains; Region: HTH; cl00088
101510019509	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510019510	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
101510019511	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
101510019512	tetramer interface [polypeptide binding]; other site
101510019513	TPP-binding site [chemical binding]; other site
101510019514	heterodimer interface [polypeptide binding]; other site
101510019515	phosphorylation loop region [posttranslational modification]
101510019516	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
101510019517	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
101510019518	alpha subunit interface [polypeptide binding]; other site
101510019519	TPP binding site [chemical binding]; other site
101510019520	heterodimer interface [polypeptide binding]; other site
101510019521	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
101510019522	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
101510019523	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510019524	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510019525	putative substrate translocation pore; other site
101510019526	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
101510019527	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614
101510019528	NAD(P) binding site [chemical binding]; other site
101510019529	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
101510019530	homotrimer interaction site [polypeptide binding]; other site
101510019531	putative active site [active]
101510019532	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
101510019533	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
101510019534	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
101510019535	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
101510019536	catalytic residue [active]
101510019537	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510019538	classical (c) SDRs; Region: SDR_c; cd05233
101510019539	NAD(P) binding site [chemical binding]; other site
101510019540	active site
101510019541	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510019542	classical (c) SDRs; Region: SDR_c; cd05233
101510019543	NAD(P) binding site [chemical binding]; other site
101510019544	active site
101510019545	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
101510019546	classical (c) SDRs; Region: SDR_c; cd05233
101510019547	NAD(P) binding site [chemical binding]; other site
101510019548	active site
101510019549	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
101510019550	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
101510019551	Helix-turn-helix domains; Region: HTH; cl00088
101510019552	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
101510019553	D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284
101510019554	NAD binding site [chemical binding]; other site
101510019555	substrate binding site [chemical binding]; other site
101510019556	catalytic Zn binding site [ion binding]; other site
101510019557	structural Zn binding site [ion binding]; other site
101510019558	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
101510019559	Amino acid permease; Region: AA_permease; cl00524
101510019560	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
101510019561	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510019562	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
101510019563	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
101510019564	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
101510019565	[2Fe-2S] cluster binding site [ion binding]; other site
101510019566	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
101510019567	alpha subunit interface [polypeptide binding]; other site
101510019568	active site
101510019569	substrate binding site [chemical binding]; other site
101510019570	Fe binding site [ion binding]; other site
101510019571	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
101510019572	Lsr2; Region: Lsr2; pfam11774
101510019573	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
101510019574	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
101510019575	Transposase, Mutator family; Region: Transposase_mut; pfam00872
101510019576	argininosuccinate lyase; Provisional; Region: PRK02186
101510019577	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
101510019578	Major Facilitator Superfamily; Region: MFS_1; pfam07690
101510019579	D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734
101510019580	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510019581	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510019582	KamA family protein; Region: TIGR00238; cl15377
101510019583	Cupin domain; Region: Cupin_2; cl09118
101510019584	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
101510019585	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510019586	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
101510019587	tRNA synthetases class I (M); Region: tRNA-synt_1g; pfam09334
101510019588	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
101510019589	active site
101510019590	nucleotide binding site [chemical binding]; other site
101510019591	HIGH motif; other site
101510019592	KMSKS motif; other site
101510019593	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
101510019594	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
101510019595	argininosuccinate lyase; Provisional; Region: PRK02186
101510019596	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
101510019597	FemAB family; Region: FemAB; cl11444
101510019598	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
101510019599	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
101510019600	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
101510019601	hydrophobic ligand binding site; other site
101510019602	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
101510019603	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510019604	Phd_YefM; Region: PhdYeFM; cl09153
101510019605	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
101510019606	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
101510019607	Uncharacterised protein family (UPF0182); Region: UPF0182; pfam03699
101510019608	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510019609	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510019610	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510019611	active site
101510019612	type III secretion system ATPase; Validated; Region: PRK05922
101510019613	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
101510019614	salt bridge; other site
101510019615	non-specific DNA binding site [nucleotide binding]; other site
101510019616	sequence-specific DNA binding site [nucleotide binding]; other site
101510019617	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
101510019618	salt bridge; other site
101510019619	non-specific DNA binding site [nucleotide binding]; other site
101510019620	sequence-specific DNA binding site [nucleotide binding]; other site
101510019621	Helix-turn-helix domains; Region: HTH; cl00088
101510019622	Domain of unknown function (DUF955); Region: DUF955; cl01076
101510019623	Peptidase family M23; Region: Peptidase_M23; pfam01551
101510019624	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
101510019625	N-acetyl-D-glucosamine binding site [chemical binding]; other site
101510019626	catalytic residue [active]
101510019627	NlpC/P60 family; Region: NLPC_P60; cl11438
101510019628	AAA-like domain; Region: AAA_10; pfam12846
101510019629	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510019630	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
101510019631	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510019632	Protein of unknown function (DUF2637); Region: DUF2637; pfam10935
101510019633	Cutinase; Region: Cutinase; cl15711
101510019634	N-formylglutamate amidohydrolase; Region: FGase; cl01522
101510019635	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
101510019636	dimerization interface [polypeptide binding]; other site
101510019637	putative DNA binding site [nucleotide binding]; other site
101510019638	putative Zn2+ binding site [ion binding]; other site
101510019639	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894
101510019640	putative hydrophobic ligand binding site [chemical binding]; other site
101510019641	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
101510019642	Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117
101510019643	homodimer interface [polypeptide binding]; other site
101510019644	putative active site [active]
101510019645	catalytic site [active]
101510019646	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510019647	Helix-turn-helix domains; Region: HTH; cl00088
101510019648	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
101510019649	Ligand Binding Site [chemical binding]; other site
101510019650	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510019651	ATP binding site [chemical binding]; other site
101510019652	Mg2+ binding site [ion binding]; other site
101510019653	G-X-G motif; other site
101510019654	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
101510019655	Amino acid permease; Region: AA_permease; cl00524
101510019656	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
101510019657	Uncharacterized conserved protein [Function unknown]; Region: COG3391
101510019658	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
101510019659	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
101510019660	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
101510019661	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510019662	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
101510019663	GAF domain; Region: GAF; cl00853
101510019664	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
101510019665	metal binding site [ion binding]; metal-binding site
101510019666	active site
101510019667	I-site; other site
101510019668	Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117
101510019669	homodimer interface [polypeptide binding]; other site
101510019670	putative active site [active]
101510019671	catalytic site [active]
101510019672	Cutinase; Region: Cutinase; cl15711
101510019673	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; cl07370
101510019674	Integrase core domain; Region: rve; cl01316
101510019675	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510019676	VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173
101510019677	active site
101510019678	conformational flexibility of ligand binding pocket; other site
101510019679	ADP-ribosylating toxin turn-turn motif; other site
101510019680	Helix-turn-helix domains; Region: HTH; cl00088
101510019681	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
101510019682	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
101510019683	Lsr2; Region: Lsr2; pfam11774
101510019684	Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015
101510019685	active site
101510019686	Uncharacterized conserved protein [Function unknown]; Region: COG3268
101510019687	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510019688	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510019689	S-adenosylmethionine binding site [chemical binding]; other site
101510019690	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
101510019691	PAS fold; Region: PAS_3; pfam08447
101510019692	putative active site [active]
101510019693	heme pocket [chemical binding]; other site
101510019694	ANTAR domain; Region: ANTAR; cl04297
101510019695	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
101510019696	RES domain; Region: RES; cl02411
101510019697	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
101510019698	RNB domain; Region: RNB; pfam00773
101510019699	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
101510019700	Protein of unknown function (DUF1016); Region: DUF1016; cl01979
101510019701	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
101510019702	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510019703	DNA binding site [nucleotide binding]
101510019704	Int/Topo IB signature motif; other site
101510019705	active site
101510019706	Protein of unknown function (DUF1016); Region: DUF1016; cl01979
101510019707	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
101510019708	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
101510019709	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
101510019710	NAD(P) binding site [chemical binding]; other site
101510019711	4-aminobutyrate aminotransferase; Provisional; Region: PRK08117
101510019712	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
101510019713	inhibitor-cofactor binding pocket; inhibition site
101510019714	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510019715	catalytic residue [active]
101510019716	Helix-turn-helix domains; Region: HTH; cl00088
101510019717	Transcriptional regulator [Transcription]; Region: LysR; COG0583
101510019718	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
101510019719	putative dimerization interface [polypeptide binding]; other site
101510019720	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
101510019721	Transcriptional regulators [Transcription]; Region: GntR; COG1802
101510019722	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510019723	DNA-binding site [nucleotide binding]; DNA binding site
101510019724	FCD domain; Region: FCD; cl11656
101510019725	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510019726	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
101510019727	tetramerization interface [polypeptide binding]; other site
101510019728	NAD(P) binding site [chemical binding]; other site
101510019729	catalytic residues [active]
101510019730	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
101510019731	FAD binding domain; Region: FAD_binding_4; pfam01565
101510019732	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
101510019733	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
101510019734	Amino acid permease; Region: AA_permease; cl00524
101510019735	Transcriptional regulators [Transcription]; Region: GntR; COG1802
101510019736	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510019737	DNA-binding site [nucleotide binding]; DNA binding site
101510019738	FCD domain; Region: FCD; cl11656
101510019739	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
101510019740	Amino acid permease; Region: AA_permease; cl00524
101510019741	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
101510019742	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
101510019743	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
101510019744	active site
101510019745	benzoate transport; Region: 2A0115; TIGR00895
101510019746	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510019747	putative substrate translocation pore; other site
101510019748	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510019749	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
101510019750	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
101510019751	putative active site [active]
101510019752	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
101510019753	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
101510019754	motif II; other site
101510019755	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
101510019756	tartrate dehydrogenase; Provisional; Region: PRK08194
101510019757	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
101510019758	Nitronate monooxygenase; Region: NMO; pfam03060
101510019759	FMN binding site [chemical binding]; other site
101510019760	substrate binding site [chemical binding]; other site
101510019761	putative catalytic residue [active]
101510019762	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
101510019763	Helix-turn-helix domains; Region: HTH; cl00088
101510019764	LysE type translocator; Region: LysE; cl00565
101510019765	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
101510019766	Citrate synthase; Region: Citrate_synt; pfam00285
101510019767	oxalacetate binding site [chemical binding]; other site
101510019768	citrylCoA binding site [chemical binding]; other site
101510019769	coenzyme A binding site [chemical binding]; other site
101510019770	catalytic triad [active]
101510019771	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
101510019772	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
101510019773	iron-sulfur cluster [ion binding]; other site
101510019774	[2Fe-2S] cluster binding site [ion binding]; other site
101510019775	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
101510019776	Ligand binding site [chemical binding]; other site
101510019777	Electron transfer flavoprotein domain; Region: ETF; pfam01012
101510019778	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
101510019779	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
101510019780	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
101510019781	Fumarase C-terminus; Region: Fumerase_C; cl00795
101510019782	Fumarate hydratase (Fumerase); Region: Fumerase; cl00851
101510019783	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
101510019784	Iron-sulfur protein interface; other site
101510019785	proximal heme binding site [chemical binding]; other site
101510019786	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
101510019787	Iron-sulfur protein interface; other site
101510019788	proximal heme binding site [chemical binding]; other site
101510019789	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263
101510019790	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510019791	domain; Region: Succ_DH_flav_C; pfam02910
101510019792	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
101510019793	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510019794	catalytic loop [active]
101510019795	iron binding site [ion binding]; other site
101510019796	galactarate dehydratase; Region: galactar-dH20; TIGR03248
101510019797	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510019798	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510019799	putative substrate translocation pore; other site
101510019800	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510019801	Helix-turn-helix domains; Region: HTH; cl00088
101510019802	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510019803	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510019804	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
101510019805	putative transposase OrfB; Reviewed; Region: PHA02517
101510019806	Integrase core domain; Region: rve; cl01316
101510019807	Helix-turn-helix domains; Region: HTH; cl00088
101510019808	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
101510019809	NAD(P) binding site [chemical binding]; other site
101510019810	catalytic residues [active]
101510019811	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
101510019812	Transcription factor WhiB; Region: Whib; pfam02467
101510019813	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510019814	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
101510019815	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510019816	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
101510019817	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
101510019818	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510019819	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
101510019820	Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721
101510019821	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
101510019822	galactarate dehydratase; Region: galactar-dH20; TIGR03248
101510019823	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510019824	DNA-binding site [nucleotide binding]; DNA binding site
101510019825	FCD domain; Region: FCD; cl11656
101510019826	Transcriptional regulator [Transcription]; Region: LysR; COG0583
101510019827	Helix-turn-helix domains; Region: HTH; cl00088
101510019828	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
101510019829	putative dimerization interface [polypeptide binding]; other site
101510019830	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
101510019831	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510019832	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510019833	active site
101510019834	ATP binding site [chemical binding]; other site
101510019835	substrate binding site [chemical binding]; other site
101510019836	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
101510019837	substrate binding site [chemical binding]; other site
101510019838	activation loop (A-loop); other site
101510019839	activation loop (A-loop); other site
101510019840	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510019841	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
101510019842	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510019843	DNA binding residues [nucleotide binding]
101510019844	dimerization interface [polypeptide binding]; other site
101510019845	Transcriptional regulators [Transcription]; Region: GntR; COG1802
101510019846	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510019847	DNA-binding site [nucleotide binding]; DNA binding site
101510019848	FCD domain; Region: FCD; cl11656
101510019849	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
101510019850	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
101510019851	active site pocket [active]
101510019852	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
101510019853	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510019854	putative substrate translocation pore; other site
101510019855	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
101510019856	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
101510019857	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
101510019858	Helix-turn-helix domains; Region: HTH; cl00088
101510019859	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
101510019860	putative metal binding site [ion binding]; other site
101510019861	enoyl-CoA hydratase; Validated; Region: PRK08139
101510019862	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510019863	substrate binding site [chemical binding]; other site
101510019864	oxyanion hole (OAH) forming residues; other site
101510019865	trimer interface [polypeptide binding]; other site
101510019866	putative acyltransferase; Provisional; Region: PRK05790
101510019867	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
101510019868	dimer interface [polypeptide binding]; other site
101510019869	active site
101510019870	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
101510019871	dimer interaction site [polypeptide binding]; other site
101510019872	substrate-binding tunnel; other site
101510019873	active site
101510019874	catalytic site [active]
101510019875	substrate binding site [chemical binding]; other site
101510019876	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510019877	Major Facilitator Superfamily; Region: MFS_1; pfam07690
101510019878	putative substrate translocation pore; other site
101510019879	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510019880	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510019881	putative substrate translocation pore; other site
101510019882	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
101510019883	DUF35 OB-fold domain; Region: DUF35; pfam01796
101510019884	thiolase; Provisional; Region: PRK06158
101510019885	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
101510019886	active site
101510019887	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
101510019888	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
101510019889	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510019890	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
101510019891	catalytic residues [active]
101510019892	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
101510019893	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510019894	Helix-turn-helix domains; Region: HTH; cl00088
101510019895	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510019896	OsmC-like protein; Region: OsmC; cl00767
101510019897	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
101510019898	Transcription factor WhiB; Region: Whib; pfam02467
101510019899	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
101510019900	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
101510019901	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510019902	homodimer interface [polypeptide binding]; other site
101510019903	catalytic residue [active]
101510019904	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
101510019905	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
101510019906	putative DNA binding site [nucleotide binding]; other site
101510019907	putative Zn2+ binding site [ion binding]; other site
101510019908	Helix-turn-helix domains; Region: HTH; cl00088
101510019909	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
101510019910	Amino acid permease; Region: AA_permease; cl00524
101510019911	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
101510019912	homotrimer interaction site [polypeptide binding]; other site
101510019913	putative active site [active]
101510019914	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
101510019915	YheO-like PAS domain; Region: PAS_6; pfam08348
101510019916	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389
101510019917	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510019918	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965
101510019919	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510019920	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510019921	active site
101510019922	ATP binding site [chemical binding]; other site
101510019923	substrate binding site [chemical binding]; other site
101510019924	activation loop (A-loop); other site
101510019925	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
101510019926	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
101510019927	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
101510019928	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510019929	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
101510019930	active site residue [active]
101510019931	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
101510019932	active site residue [active]
101510019933	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
101510019934	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
101510019935	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
101510019936	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510019937	DNA-binding site [nucleotide binding]; DNA binding site
101510019938	UTRA domain; Region: UTRA; cl01230
101510019939	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
101510019940	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510019941	Helix-turn-helix domains; Region: HTH; cl00088
101510019942	Helix-turn-helix domains; Region: HTH; cl00088
101510019943	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510019944	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510019945	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510019946	Helix-turn-helix domains; Region: HTH; cl00088
101510019947	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
101510019948	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510019949	OsmC-like protein; Region: OsmC; cl00767
101510019950	Protein of unknown function (DUF1326); Region: DUF1326; cl02375
101510019951	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
101510019952	active site
101510019953	FMN binding site [chemical binding]; other site
101510019954	substrate binding site [chemical binding]; other site
101510019955	putative catalytic residue [active]
101510019956	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
101510019957	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510019958	NAD(P) binding site [chemical binding]; other site
101510019959	catalytic residues [active]
101510019960	Protein of unknown function (DUF779); Region: DUF779; cl01432
101510019961	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
101510019962	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780
101510019963	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780
101510019964	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
101510019965	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
101510019966	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
101510019967	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
101510019968	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
101510019969	carboxyltransferase (CT) interaction site; other site
101510019970	biotinylation site [posttranslational modification]; other site
101510019971	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
101510019972	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
101510019973	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510019974	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
101510019975	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
101510019976	Malic enzyme, N-terminal domain; Region: malic; pfam00390
101510019977	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
101510019978	putative NAD(P) binding site [chemical binding]; other site
101510019979	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
101510019980	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
101510019981	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510019982	OsmC-like protein; Region: OsmC; cl00767
101510019983	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510019984	putative substrate translocation pore; other site
101510019985	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510019986	enoyl-CoA hydratase; Validated; Region: PRK08139
101510019987	substrate binding site [chemical binding]; other site
101510019988	oxyanion hole (OAH) forming residues; other site
101510019989	trimer interface [polypeptide binding]; other site
101510019990	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510019991	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
101510019992	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
101510019993	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
101510019994	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
101510019995	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
101510019996	Integrase core domain; Region: rve; cl01316
101510019997	Cupin domain; Region: Cupin_2; cl09118
101510019998	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
101510019999	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510020000	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510020001	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510020002	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510020003	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
101510020004	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510020005	NAD(P) binding site [chemical binding]; other site
101510020006	active site
101510020007	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
101510020008	intersubunit interface [polypeptide binding]; other site
101510020009	active site
101510020010	Zn2+ binding site [ion binding]; other site
101510020011	Flavin Reductases; Region: FlaRed; cl00801
101510020012	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
101510020013	active site
101510020014	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
101510020015	dimer interface [polypeptide binding]; other site
101510020016	non-prolyl cis peptide bond; other site
101510020017	insertion regions; other site
101510020018	Domain of unknown function (DUF336); Region: DUF336; cl01249
101510020019	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
101510020020	D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284
101510020021	NAD binding site [chemical binding]; other site
101510020022	substrate binding site [chemical binding]; other site
101510020023	catalytic Zn binding site [ion binding]; other site
101510020024	structural Zn binding site [ion binding]; other site
101510020025	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
101510020026	Helix-turn-helix domains; Region: HTH; cl00088
101510020027	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
101510020028	dimerization interface [polypeptide binding]; other site
101510020029	substrate binding pocket [chemical binding]; other site
101510020030	choline dehydrogenase; Validated; Region: PRK02106
101510020031	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cl00253
101510020032	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
101510020033	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
101510020034	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
101510020035	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
101510020036	inhibitor site; inhibition site
101510020037	active site
101510020038	dimer interface [polypeptide binding]; other site
101510020039	catalytic residue [active]
101510020040	4-coumarate--CoA ligase; Region: PLN02246
101510020041	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510020042	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
101510020043	phosphate binding site [ion binding]; other site
101510020044	Transposase [DNA replication, recombination, and repair]; Region: COG5421
101510020045	Transposase; Region: DEDD_Tnp_IS110; pfam01548
101510020046	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
101510020047	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
101510020048	active site
101510020049	Zn2+ binding site [ion binding]; other site
101510020050	intersubunit interface [polypeptide binding]; other site
101510020051	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
101510020052	ATP binding site [chemical binding]; other site
101510020053	substrate binding site [chemical binding]; other site
101510020054	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
101510020055	classical (c) SDRs; Region: SDR_c; cd05233
101510020056	NAD(P) binding site [chemical binding]; other site
101510020057	active site
101510020058	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510020059	hypothetical protein; Provisional; Region: PRK06194
101510020060	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
101510020061	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510020062	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510020063	NAD(P) binding site [chemical binding]; other site
101510020064	active site
101510020065	Cytochrome P450; Region: p450; cl12078
101510020066	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
101510020067	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
101510020068	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510020069	Helix-turn-helix domains; Region: HTH; cl00088
101510020070	Helix-turn-helix domains; Region: HTH; cl00088
101510020071	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
101510020072	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
101510020073	putative ligand binding site [chemical binding]; other site
101510020074	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
101510020075	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
101510020076	Walker A/P-loop; other site
101510020077	ATP binding site [chemical binding]; other site
101510020078	Q-loop/lid; other site
101510020079	ABC transporter signature motif; other site
101510020080	Walker B; other site
101510020081	D-loop; other site
101510020082	H-loop/switch region; other site
101510020083	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
101510020084	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
101510020085	Walker A/P-loop; other site
101510020086	ATP binding site [chemical binding]; other site
101510020087	Q-loop/lid; other site
101510020088	ABC transporter signature motif; other site
101510020089	Walker B; other site
101510020090	D-loop; other site
101510020091	H-loop/switch region; other site
101510020092	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510020093	hypothetical protein; Validated; Region: PRK07121
101510020094	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
101510020095	active site
101510020096	FMN binding site [chemical binding]; other site
101510020097	substrate binding site [chemical binding]; other site
101510020098	putative catalytic residue [active]
101510020099	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
101510020100	Helix-turn-helix domains; Region: HTH; cl00088
101510020101	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
101510020102	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
101510020103	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510020104	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510020105	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
101510020106	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
101510020107	FAD binding pocket [chemical binding]; other site
101510020108	FAD binding motif [chemical binding]; other site
101510020109	phosphate binding motif [ion binding]; other site
101510020110	beta-alpha-beta structure motif; other site
101510020111	NAD(p) ribose binding residues [chemical binding]; other site
101510020112	NAD binding pocket [chemical binding]; other site
101510020113	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
101510020114	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510020115	catalytic loop [active]
101510020116	iron binding site [ion binding]; other site
101510020117	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
101510020118	The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH).  The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531
101510020119	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510020120	active site
101510020121	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
101510020122	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
101510020123	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
101510020124	active site
101510020125	Fe binding site [ion binding]; other site
101510020126	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510020127	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
101510020128	active site
101510020129	metal binding site [ion binding]; metal-binding site
101510020130	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510020131	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
101510020132	NAD(P) binding site [chemical binding]; other site
101510020133	active site
101510020134	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
101510020135	Integrase core domain; Region: rve; cl01316
101510020136	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510020137	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
101510020138	substrate binding pocket [chemical binding]; other site
101510020139	Flavin Reductases; Region: FlaRed; cl00801
101510020140	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
101510020141	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510020142	Stress responsive A/B Barrel Domain; Region: Dabb; cl06768
101510020143	Helix-turn-helix domains; Region: HTH; cl00088
101510020144	acetaldehyde dehydrogenase; Validated; Region: PRK08300
101510020145	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510020146	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
101510020147	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
101510020148	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
101510020149	active site
101510020150	catalytic residues [active]
101510020151	metal binding site [ion binding]; metal-binding site
101510020152	DmpG-like communication domain; Region: DmpG_comm; pfam07836
101510020153	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
101510020154	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510020155	Helix-turn-helix domains; Region: HTH; cl00088
101510020156	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510020157	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510020158	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843
101510020159	3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837
101510020160	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510020161	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510020162	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
101510020163	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510020164	Transcriptional regulators [Transcription]; Region: GntR; COG1802
101510020165	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510020166	DNA-binding site [nucleotide binding]; DNA binding site
101510020167	FCD domain; Region: FCD; cl11656
101510020168	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
101510020169	CoA-transferase family III; Region: CoA_transf_3; pfam02515
101510020170	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510020171	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510020172	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510020173	active site
101510020174	enoyl-CoA hydratase; Provisional; Region: PRK05870
101510020175	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510020176	substrate binding site [chemical binding]; other site
101510020177	oxyanion hole (OAH) forming residues; other site
101510020178	trimer interface [polypeptide binding]; other site
101510020179	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
101510020180	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510020181	NAD(P) binding site [chemical binding]; other site
101510020182	active site
101510020183	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510020184	Helix-turn-helix domains; Region: HTH; cl00088
101510020185	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510020186	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510020187	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
101510020188	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
101510020189	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510020190	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510020191	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510020192	classical (c) SDRs; Region: SDR_c; cd05233
101510020193	hypothetical protein; Provisional; Region: PRK06194
101510020194	NAD(P) binding site [chemical binding]; other site
101510020195	active site
101510020196	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
101510020197	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510020198	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843
101510020199	enoyl-CoA hydratase; Region: PLN02864
101510020200	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
101510020201	active site 2 [active]
101510020202	active site 1 [active]
101510020203	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
101510020204	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
101510020205	Walker A/P-loop; other site
101510020206	ATP binding site [chemical binding]; other site
101510020207	Q-loop/lid; other site
101510020208	ABC transporter signature motif; other site
101510020209	Walker B; other site
101510020210	D-loop; other site
101510020211	H-loop/switch region; other site
101510020212	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
101510020213	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
101510020214	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
101510020215	Walker A/P-loop; other site
101510020216	ATP binding site [chemical binding]; other site
101510020217	Q-loop/lid; other site
101510020218	ABC transporter signature motif; other site
101510020219	Walker B; other site
101510020220	D-loop; other site
101510020221	H-loop/switch region; other site
101510020222	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
101510020223	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
101510020224	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510020225	putative PBP binding loops; other site
101510020226	dimer interface [polypeptide binding]; other site
101510020227	ABC-ATPase subunit interface; other site
101510020228	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
101510020229	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510020230	dimer interface [polypeptide binding]; other site
101510020231	conserved gate region; other site
101510020232	putative PBP binding loops; other site
101510020233	ABC-ATPase subunit interface; other site
101510020234	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
101510020235	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
101510020236	Flavin Reductases; Region: FlaRed; cl00801
101510020237	EthD protein; Region: EthD; cl06234
101510020238	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
101510020239	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510020240	Transcriptional regulator [Transcription]; Region: IclR; COG1414
101510020241	Helix-turn-helix domains; Region: HTH; cl00088
101510020242	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
101510020243	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510020244	OsmC-like protein; Region: OsmC; cl00767
101510020245	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
101510020246	FMN binding site [chemical binding]; other site
101510020247	active site
101510020248	substrate binding site [chemical binding]; other site
101510020249	catalytic residue [active]
101510020250	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
101510020251	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
101510020252	catalytic residues [active]
101510020253	classical (c) SDRs; Region: SDR_c; cd05233
101510020254	NAD(P) binding site [chemical binding]; other site
101510020255	active site
101510020256	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510020257	Helix-turn-helix domains; Region: HTH; cl00088
101510020258	Integrase core domain; Region: rve; cl01316
101510020259	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
101510020260	catalytic residues [active]
101510020261	catalytic nucleophile [active]
101510020262	Helix-turn-helix domains; Region: HTH; cl00088
101510020263	Winged helix-turn helix; Region: HTH_29; pfam13551
101510020264	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
101510020265	classical (c) SDRs; Region: SDR_c; cd05233
101510020266	NAD(P) binding site [chemical binding]; other site
101510020267	active site
101510020268	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510020269	classical (c) SDRs; Region: SDR_c; cd05233
101510020270	NAD(P) binding site [chemical binding]; other site
101510020271	active site
101510020272	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
101510020273	TM-ABC transporter signature motif; other site
101510020274	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
101510020275	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
101510020276	Walker A/P-loop; other site
101510020277	ATP binding site [chemical binding]; other site
101510020278	Q-loop/lid; other site
101510020279	ABC transporter signature motif; other site
101510020280	Walker B; other site
101510020281	D-loop; other site
101510020282	H-loop/switch region; other site
101510020283	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
101510020284	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
101510020285	ligand binding site [chemical binding]; other site
101510020286	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
101510020287	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510020288	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
101510020289	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510020290	Flavin Reductases; Region: FlaRed; cl00801
101510020291	Bacterial protein of unknown function (DUF894); Region: DUF894; pfam05977
101510020292	tricarballylate dehydrogenase; Validated; Region: PRK08274
101510020293	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510020294	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510020295	Secretory lipase; Region: LIP; pfam03583
101510020296	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
101510020297	Transcription factor WhiB; Region: Whib; pfam02467
101510020298	Lsr2; Region: Lsr2; pfam11774
101510020299	Lsr2; Region: Lsr2; pfam11774
101510020300	Lsr2; Region: Lsr2; pfam11774
101510020301	Lsr2; Region: Lsr2; pfam11774
101510020302	Helix-turn-helix domains; Region: HTH; cl00088
101510020303	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924
101510020304	Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795
101510020305	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
101510020306	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
101510020307	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510020308	Walker A/P-loop; other site
101510020309	ATP binding site [chemical binding]; other site
101510020310	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
101510020311	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
101510020312	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510020313	Walker B; other site
101510020314	D-loop; other site
101510020315	H-loop/switch region; other site
101510020316	Domain of unknown function (DUF1883); Region: DUF1883; pfam08980
101510020317	TIR domain; Region: TIR; cl02060
101510020318	TIR domain; Region: TIR_2; cl15770
101510020319	TIR domain; Region: TIR; cl02060
101510020320	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
101510020321	TIR domain; Region: TIR; cl02060
101510020322	Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487
101510020323	active site
101510020324	catalytic triad [active]
101510020325	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
101510020326	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510020327	putative transposase OrfB; Reviewed; Region: PHA02517
101510020328	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942
101510020329	aromatic arch; other site
101510020330	DCoH dimer interaction site [polypeptide binding]; other site
101510020331	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
101510020332	DCoH tetramer interaction site [polypeptide binding]; other site
101510020333	substrate binding site [chemical binding]; other site
101510020334	Peptidase family M23; Region: Peptidase_M23; pfam01551
101510020335	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599
101510020336	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
101510020337	active site
101510020338	Integrase core domain; Region: rve; cl01316
101510020339	putative transposase OrfB; Reviewed; Region: PHA02517
101510020340	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
101510020341	catalytic residue [active]
101510020342	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
101510020343	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
101510020344	active site
101510020345	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
101510020346	Salmonella virulence plasmid 28.1kDa A protein; Region: VRP1; cl04143
101510020347	PA14 domain; Region: PA14; cl08459
101510020348	Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534
101510020349	Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256
101510020350	Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255
101510020351	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
101510020352	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
101510020353	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
101510020354	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
101510020355	Domain of unknown function (DUF3560); Region: DUF3560; pfam12083
101510020356	hypothetical protein; Validated; Region: PRK07078
101510020357	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
101510020358	active site
101510020359	metal binding site [ion binding]; metal-binding site
101510020360	interdomain interaction site; other site
101510020361	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
101510020362	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
101510020363	Magnesium ion binding site [ion binding]; other site
101510020364	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
101510020365	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
101510020366	Cutinase; Region: Cutinase; cl15711
101510020367	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
101510020368	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
101510020369	type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746
101510020370	AAA-like domain; Region: AAA_10; pfam12846
101510020371	Peptidase family M23; Region: Peptidase_M23; pfam01551
101510020372	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
101510020373	N-acetyl-D-glucosamine binding site [chemical binding]; other site
101510020374	catalytic residue [active]
101510020375	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510020376	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
101510020377	Transposase; Region: DEDD_Tnp_IS110; pfam01548
101510020378	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
101510020379	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
101510020380	non-specific DNA binding site [nucleotide binding]; other site
101510020381	salt bridge; other site
101510020382	sequence-specific DNA binding site [nucleotide binding]; other site
101510020383	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
101510020384	non-specific DNA binding site [nucleotide binding]; other site
101510020385	salt bridge; other site
101510020386	sequence-specific DNA binding site [nucleotide binding]; other site
101510020387	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510020388	Helix-turn-helix domains; Region: HTH; cl00088
101510020389	SAF domain; Region: SAF; cl00555
101510020390	Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630
101510020391	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510020392	ATP binding site [chemical binding]; other site
101510020393	Walker B motif; other site
101510020394	Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
101510020395	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
101510020396	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
101510020397	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510020398	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510020399	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
101510020400	NlpC/P60 family; Region: NLPC_P60; cl11438
101510020401	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
101510020402	active site
101510020403	substrate binding site [chemical binding]; other site
101510020404	catalytic site [active]
101510020405	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
101510020406	Active Sites [active]
101510020407	CRISPR/Cas system-associated RAMP superfamily protein Csf3; Region: Csf3_U; cl11865
101510020408	Transcription factor WhiB; Region: Whib; pfam02467
101510020409	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
101510020410	Integrase core domain; Region: rve; cl01316
101510020411	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
101510020412	non-specific DNA binding site [nucleotide binding]; other site
101510020413	salt bridge; other site
101510020414	sequence-specific DNA binding site [nucleotide binding]; other site
101510020415	Domain of unknown function (DUF955); Region: DUF955; cl01076
101510020416	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
101510020417	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
101510020418	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
101510020419	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
101510020420	Helicase associated domain; Region: HA; pfam03457
101510020421	Helicase associated domain; Region: HA; pfam03457
101510020422	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
101510020423	putative active site [active]
101510020424	catalytic site [active]
101510020425	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
101510020426	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510020427	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510020428	DNA binding site [nucleotide binding]
101510020429	active site
101510020430	Int/Topo IB signature motif; other site
101510020431	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
101510020432	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
101510020433	active site
101510020434	catalytic residues [active]
101510020435	metal binding site [ion binding]; metal-binding site
101510020436	DmpG-like communication domain; Region: DmpG_comm; pfam07836
101510020437	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
101510020438	acetaldehyde dehydrogenase; Validated; Region: PRK08300
101510020439	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
101510020440	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
101510020441	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510020442	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
101510020443	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
101510020444	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510020445	substrate binding site [chemical binding]; other site
101510020446	oxyanion hole (OAH) forming residues; other site
101510020447	trimer interface [polypeptide binding]; other site
101510020448	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510020449	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
101510020450	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
101510020451	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510020452	active site
101510020453	phosphorylation site [posttranslational modification]
101510020454	intermolecular recognition site; other site
101510020455	dimerization interface [polypeptide binding]; other site
101510020456	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510020457	DNA binding residues [nucleotide binding]
101510020458	dimerization interface [polypeptide binding]; other site
101510020459	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
101510020460	active site
101510020461	ATP binding site [chemical binding]; other site
101510020462	substrate binding site [chemical binding]; other site
101510020463	activation loop (A-loop); other site
101510020464	Predicted ATPase [General function prediction only]; Region: COG3899
101510020465	Histidine kinase; Region: HisKA_3; pfam07730
101510020466	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510020467	ATP binding site [chemical binding]; other site
101510020468	Mg2+ binding site [ion binding]; other site
101510020469	G-X-G motif; other site
101510020470	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
101510020471	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510020472	cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348
101510020473	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
101510020474	NAD binding site [chemical binding]; other site
101510020475	active site
101510020476	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510020477	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
101510020478	NAD(P) binding site [chemical binding]; other site
101510020479	catalytic residues [active]
101510020480	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
101510020481	active site
101510020482	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
101510020483	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
101510020484	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510020485	active site
101510020486	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
101510020487	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
101510020488	iron-sulfur cluster [ion binding]; other site
101510020489	[2Fe-2S] cluster binding site [ion binding]; other site
101510020490	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
101510020491	beta subunit interface [polypeptide binding]; other site
101510020492	alpha subunit interface [polypeptide binding]; other site
101510020493	active site
101510020494	substrate binding site [chemical binding]; other site
101510020495	Fe binding site [ion binding]; other site
101510020496	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
101510020497	inter-subunit interface; other site
101510020498	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
101510020499	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
101510020500	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
101510020501	active site
101510020502	Fe binding site [ion binding]; other site
101510020503	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
101510020504	homoserine O-acetyltransferase; Provisional; Region: metX; cl15472
101510020505	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
101510020506	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
101510020507	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
101510020508	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510020509	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
101510020510	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510020511	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
101510020512	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
101510020513	iron-sulfur cluster [ion binding]; other site
101510020514	[2Fe-2S] cluster binding site [ion binding]; other site
101510020515	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
101510020516	beta subunit interface [polypeptide binding]; other site
101510020517	alpha subunit interface [polypeptide binding]; other site
101510020518	active site
101510020519	substrate binding site [chemical binding]; other site
101510020520	Fe binding site [ion binding]; other site
101510020521	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
101510020522	inter-subunit interface; other site
101510020523	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
101510020524	[2Fe-2S] cluster binding site [ion binding]; other site
101510020525	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
101510020526	homoserine O-acetyltransferase; Provisional; Region: metX; cl15472
101510020527	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510020528	Major Facilitator Superfamily; Region: MFS_1; pfam07690
101510020529	putative substrate translocation pore; other site
101510020530	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510020531	active site
101510020532	ATP binding site [chemical binding]; other site
101510020533	substrate binding site [chemical binding]; other site
101510020534	activation loop (A-loop); other site
101510020535	Predicted ATPase [General function prediction only]; Region: COG3899
101510020536	Histidine kinase; Region: HisKA_3; pfam07730
101510020537	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510020538	ATP binding site [chemical binding]; other site
101510020539	Mg2+ binding site [ion binding]; other site
101510020540	G-X-G motif; other site
101510020541	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
101510020542	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
101510020543	Transposase; Region: DEDD_Tnp_IS110; pfam01548
101510020544	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
101510020545	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
101510020546	SCP-2 sterol transfer family; Region: SCP2; cl01225
101510020547	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
101510020548	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
101510020549	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
101510020550	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
101510020551	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668
101510020552	Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647
101510020553	Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882
101510020554	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
101510020555	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
101510020556	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668
101510020557	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
101510020558	Helix-turn-helix domains; Region: HTH; cl00088
101510020559	Helix-turn-helix domains; Region: HTH; cl00088
101510020560	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
101510020561	Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358
101510020562	putative ligand binding site [chemical binding]; other site
101510020563	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
101510020564	multimer interface [polypeptide binding]; other site
101510020565	active site
101510020566	catalytic triad [active]
101510020567	dimer interface [polypeptide binding]; other site
101510020568	Tubulin like; Region: Tubulin_2; pfam13809
101510020569	transcriptional activator RhaR; Provisional; Region: PRK13501
101510020570	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510020571	High-affinity nickel-transport protein; Region: NicO; cl00964
101510020572	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
101510020573	succinate CoA transferases; Region: YgfH_subfam; TIGR03458
101510020574	Transposase; Region: DEDD_Tnp_IS110; pfam01548
101510020575	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
101510020576	acetyl-CoA synthetase; Provisional; Region: PRK00174
101510020577	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510020578	classical (c) SDRs; Region: SDR_c; cd05233
101510020579	NAD(P) binding site [chemical binding]; other site
101510020580	active site
101510020581	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
101510020582	classical (c) SDRs; Region: SDR_c; cd05233
101510020583	NAD(P) binding site [chemical binding]; other site
101510020584	active site
101510020585	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
101510020586	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
101510020587	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510020588	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
101510020589	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
101510020590	Helix-turn-helix domains; Region: HTH; cl00088
101510020591	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
101510020592	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510020593	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
101510020594	EthD protein; Region: EthD; cl06234
101510020595	homoserine O-acetyltransferase; Provisional; Region: metX; cl15472
101510020596	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
101510020597	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
101510020598	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
101510020599	Integrase core domain; Region: rve; cl01316
101510020600	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
101510020601	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
101510020602	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
101510020603	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
101510020604	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
101510020605	putative active site [active]
101510020606	putative NTP binding site [chemical binding]; other site
101510020607	putative nucleic acid binding site [nucleotide binding]; other site
101510020608	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
101510020609	benzoate transport; Region: 2A0115; TIGR00895
101510020610	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510020611	putative substrate translocation pore; other site
101510020612	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
101510020613	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510020614	catalytic loop [active]
101510020615	iron binding site [ion binding]; other site
101510020616	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
101510020617	FAD binding pocket [chemical binding]; other site
101510020618	FAD binding motif [chemical binding]; other site
101510020619	phosphate binding motif [ion binding]; other site
101510020620	beta-alpha-beta structure motif; other site
101510020621	NAD binding pocket [chemical binding]; other site
101510020622	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
101510020623	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
101510020624	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
101510020625	inter-subunit interface; other site
101510020626	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
101510020627	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
101510020628	iron-sulfur cluster [ion binding]; other site
101510020629	[2Fe-2S] cluster binding site [ion binding]; other site
101510020630	C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880
101510020631	putative alpha subunit interface [polypeptide binding]; other site
101510020632	putative active site [active]
101510020633	putative substrate binding site [chemical binding]; other site
101510020634	Fe binding site [ion binding]; other site
101510020635	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
101510020636	Helix-turn-helix domains; Region: HTH; cl00088
101510020637	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510020638	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
101510020639	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
101510020640	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
101510020641	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
101510020642	Walker A/P-loop; other site
101510020643	ATP binding site [chemical binding]; other site
101510020644	Q-loop/lid; other site
101510020645	ABC transporter signature motif; other site
101510020646	Walker B; other site
101510020647	D-loop; other site
101510020648	H-loop/switch region; other site
101510020649	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510020650	dimer interface [polypeptide binding]; other site
101510020651	conserved gate region; other site
101510020652	putative PBP binding loops; other site
101510020653	ABC-ATPase subunit interface; other site
101510020654	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
101510020655	dimer interface [polypeptide binding]; other site
101510020656	conserved gate region; other site
101510020657	putative PBP binding loops; other site
101510020658	ABC-ATPase subunit interface; other site
101510020659	Isochorismatase family; Region: Isochorismatase; pfam00857
101510020660	N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015
101510020661	substrate binding site [chemical binding]; other site
101510020662	catalytic triad [active]
101510020663	domain interfaces; other site
101510020664	conserved cis-peptide bond; other site
101510020665	Helix-turn-helix domains; Region: HTH; cl00088
101510020666	Bacterial transcriptional regulator; Region: IclR; pfam01614
101510020667	Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535
101510020668	alpha subunit interaction site [polypeptide binding]; other site
101510020669	beta subunit interaction site [polypeptide binding]; other site
101510020670	iron-sulfur cluster [ion binding]; other site
101510020671	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
101510020672	beta subunit interface [polypeptide binding]; other site
101510020673	alpha subunit interface [polypeptide binding]; other site
101510020674	active site
101510020675	substrate binding site [chemical binding]; other site
101510020676	Fe binding site [ion binding]; other site
101510020677	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
101510020678	inter-subunit interface; other site
101510020679	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510020680	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510020681	NAD(P) binding site [chemical binding]; other site
101510020682	active site
101510020683	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
101510020684	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510020685	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
101510020686	intersubunit interface [polypeptide binding]; other site
101510020687	active site
101510020688	Zn2+ binding site [ion binding]; other site
101510020689	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
101510020690	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
101510020691	Integrase core domain; Region: rve; cl01316
101510020692	Integrase core domain; Region: rve; cl01316
101510020693	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
101510020694	Prostaglandin dehydrogenases; Region: PGDH; cd05288
101510020695	NAD(P) binding site [chemical binding]; other site
101510020696	substrate binding site [chemical binding]; other site
101510020697	dimer interface [polypeptide binding]; other site
101510020698	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510020699	Protein of unknown function (DUF3237); Region: DUF3237; cl07905
101510020700	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510020701	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
101510020702	substrate binding pocket [chemical binding]; other site
101510020703	Cupin domain; Region: Cupin_2; cl09118
101510020704	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
101510020705	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510020706	tetrameric interface [polypeptide binding]; other site
101510020707	NAD binding site [chemical binding]; other site
101510020708	catalytic residues [active]
101510020709	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
101510020710	active site
101510020711	metal binding site [ion binding]; metal-binding site
101510020712	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
101510020713	classical (c) SDRs; Region: SDR_c; cd05233
101510020714	NAD(P) binding site [chemical binding]; other site
101510020715	active site
101510020716	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510020717	Helix-turn-helix domains; Region: HTH; cl00088
101510020718	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
101510020719	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510020720	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510020721	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510020722	active site
101510020723	ATP binding site [chemical binding]; other site
101510020724	substrate binding site [chemical binding]; other site
101510020725	activation loop (A-loop); other site
101510020726	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510020727	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
101510020728	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510020729	DNA binding residues [nucleotide binding]
101510020730	dimerization interface [polypeptide binding]; other site
101510020731	Uncharacterized conserved protein [Function unknown]; Region: COG3268
101510020732	Uncharacterized conserved protein [Function unknown]; Region: COG3268
101510020733	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510020734	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
101510020735	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
101510020736	Peptidase family M23; Region: Peptidase_M23; pfam01551
101510020737	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
101510020738	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
101510020739	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
101510020740	putative transposase OrfB; Reviewed; Region: PHA02517
101510020741	Integrase core domain; Region: rve; cl01316
101510020742	Helix-turn-helix domains; Region: HTH; cl00088
101510020743	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
101510020744	Transposase domain (DUF772); Region: DUF772; cl15789
101510020745	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510020746	Helix-turn-helix domains; Region: HTH; cl00088
101510020747	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
101510020748	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510020749	putative substrate translocation pore; other site
101510020750	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510020751	NAD(P) binding site [chemical binding]; other site
101510020752	active site
101510020753	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
101510020754	short chain dehydrogenase; Provisional; Region: PRK08278
101510020755	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510020756	NAD(P) binding site [chemical binding]; other site
101510020757	active site
101510020758	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
101510020759	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
101510020760	putative NAD(P) binding site [chemical binding]; other site
101510020761	catalytic Zn binding site [ion binding]; other site
101510020762	Transposase, Mutator family; Region: Transposase_mut; pfam00872
101510020763	MULE transposase domain; Region: MULE; pfam10551
101510020764	putative transposase OrfB; Reviewed; Region: PHA02517
101510020765	Integrase core domain; Region: rve; cl01316
101510020766	Helix-turn-helix domains; Region: HTH; cl00088
101510020767	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
101510020768	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510020769	DNA binding site [nucleotide binding]
101510020770	Int/Topo IB signature motif; other site
101510020771	active site
101510020772	Phage integrase family; Region: Phage_integrase; pfam00589
101510020773	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
101510020774	DNA binding site [nucleotide binding]
101510020775	Int/Topo IB signature motif; other site
101510020776	active site
101510020777	catalytic residues [active]
101510020778	Transposase, Mutator family; Region: Transposase_mut; pfam00872
101510020779	DoxX; Region: DoxX; cl00976
101510020780	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
101510020781	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
101510020782	phosphate binding site [ion binding]; other site
101510020783	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510020784	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
101510020785	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510020786	Major Facilitator Superfamily; Region: MFS_1; pfam07690
101510020787	putative substrate translocation pore; other site
101510020788	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
101510020789	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
101510020790	FMN-binding pocket [chemical binding]; other site
101510020791	flavin binding motif; other site
101510020792	phosphate binding motif [ion binding]; other site
101510020793	beta-alpha-beta structure motif; other site
101510020794	NAD binding pocket [chemical binding]; other site
101510020795	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510020796	catalytic loop [active]
101510020797	iron binding site [ion binding]; other site
101510020798	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
101510020799	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
101510020800	iron-sulfur cluster [ion binding]; other site
101510020801	[2Fe-2S] cluster binding site [ion binding]; other site
101510020802	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
101510020803	Transcriptional regulators [Transcription]; Region: FadR; COG2186
101510020804	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510020805	DNA-binding site [nucleotide binding]; DNA binding site
101510020806	FCD domain; Region: FCD; cl11656
101510020807	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614
101510020808	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
101510020809	FAD binding domain; Region: FAD_binding_4; pfam01565
101510020810	D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370
101510020811	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510020812	NAD(P) binding site [chemical binding]; other site
101510020813	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
101510020814	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510020815	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510020816	classical (c) SDRs; Region: SDR_c; cd05233
101510020817	NAD(P) binding site [chemical binding]; other site
101510020818	active site
101510020819	acyl-CoA synthetase; Validated; Region: PRK07798
101510020820	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510020821	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510020822	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510020823	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
101510020824	NAD(P) binding site [chemical binding]; other site
101510020825	catalytic residues [active]
101510020826	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
101510020827	Transposase, Mutator family; Region: Transposase_mut; pfam00872
101510020828	MULE transposase domain; Region: MULE; pfam10551
101510020829	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510020830	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
101510020831	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
101510020832	active site
101510020833	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510020834	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
101510020835	active site
101510020836	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
101510020837	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
101510020838	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510020839	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510020840	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
101510020841	Helix-turn-helix domains; Region: HTH; cl00088
101510020842	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
101510020843	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
101510020844	enoyl-CoA hydratase; Provisional; Region: PRK08290
101510020845	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510020846	substrate binding site [chemical binding]; other site
101510020847	oxyanion hole (OAH) forming residues; other site
101510020848	trimer interface [polypeptide binding]; other site
101510020849	FAD binding domain; Region: FAD_binding_3; pfam01494
101510020850	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510020851	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
101510020852	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
101510020853	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
101510020854	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
101510020855	active site
101510020856	metal binding site [ion binding]; metal-binding site
101510020857	C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360
101510020858	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
101510020859	putative active site [active]
101510020860	putative metal binding site [ion binding]; other site
101510020861	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510020862	enoyl-CoA hydratase; Provisional; Region: PRK06210
101510020863	substrate binding site [chemical binding]; other site
101510020864	oxyanion hole (OAH) forming residues; other site
101510020865	trimer interface [polypeptide binding]; other site
101510020866	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
101510020867	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510020868	NAD(P) binding site [chemical binding]; other site
101510020869	active site
101510020870	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
101510020871	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
101510020872	dimer interface [polypeptide binding]; other site
101510020873	active site
101510020874	enoyl-CoA hydratase; Provisional; Region: PRK08252
101510020875	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510020876	substrate binding site [chemical binding]; other site
101510020877	oxyanion hole (OAH) forming residues; other site
101510020878	trimer interface [polypeptide binding]; other site
101510020879	Transposase; Region: DEDD_Tnp_IS110; pfam01548
101510020880	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
101510020881	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
101510020882	putative ligand binding site [chemical binding]; other site
101510020883	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
101510020884	TM-ABC transporter signature motif; other site
101510020885	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
101510020886	TM-ABC transporter signature motif; other site
101510020887	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
101510020888	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
101510020889	Walker A/P-loop; other site
101510020890	ATP binding site [chemical binding]; other site
101510020891	Q-loop/lid; other site
101510020892	ABC transporter signature motif; other site
101510020893	Walker B; other site
101510020894	D-loop; other site
101510020895	H-loop/switch region; other site
101510020896	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
101510020897	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
101510020898	Walker A/P-loop; other site
101510020899	ATP binding site [chemical binding]; other site
101510020900	Q-loop/lid; other site
101510020901	ABC transporter signature motif; other site
101510020902	Walker B; other site
101510020903	D-loop; other site
101510020904	H-loop/switch region; other site
101510020905	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
101510020906	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510020907	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510020908	NAD(P) binding site [chemical binding]; other site
101510020909	active site
101510020910	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510020911	Helix-turn-helix domains; Region: HTH; cl00088
101510020912	Transcriptional regulators [Transcription]; Region: FadR; COG2186
101510020913	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510020914	DNA-binding site [nucleotide binding]; DNA binding site
101510020915	FCD domain; Region: FCD; cl11656
101510020916	Transcriptional regulators [Transcription]; Region: FadR; COG2186
101510020917	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510020918	DNA-binding site [nucleotide binding]; DNA binding site
101510020919	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510020920	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510020921	active site
101510020922	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
101510020923	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
101510020924	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
101510020925	DUF35 OB-fold domain; Region: DUF35; pfam01796
101510020926	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
101510020927	CoenzymeA binding site [chemical binding]; other site
101510020928	subunit interaction site [polypeptide binding]; other site
101510020929	PHB binding site; other site
101510020930	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
101510020931	Helix-turn-helix domains; Region: HTH; cl00088
101510020932	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
101510020933	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
101510020934	putative active site [active]
101510020935	putative CoA binding site [chemical binding]; other site
101510020936	nudix motif; other site
101510020937	metal binding site [ion binding]; metal-binding site
101510020938	lipid-transfer protein; Provisional; Region: PRK07855
101510020939	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
101510020940	active site
101510020941	Transcriptional regulators [Transcription]; Region: FadR; COG2186
101510020942	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510020943	DNA-binding site [nucleotide binding]; DNA binding site
101510020944	FCD domain; Region: FCD; cl11656
101510020945	Transcriptional regulators [Transcription]; Region: FadR; COG2186
101510020946	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510020947	DNA-binding site [nucleotide binding]; DNA binding site
101510020948	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510020949	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
101510020950	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
101510020951	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
101510020952	GTP cyclohydrolase I; Provisional; Region: PLN03044
101510020953	homodecamer interface [polypeptide binding]; other site
101510020954	active site
101510020955	putative catalytic site residues [active]
101510020956	zinc binding site [ion binding]; other site
101510020957	GTP-CH-I/GFRP interaction surface; other site
101510020958	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
101510020959	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
101510020960	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
101510020961	DoxX; Region: DoxX; cl00976
101510020962	classical (c) SDRs; Region: SDR_c; cd05233
101510020963	NAD(P) binding site [chemical binding]; other site
101510020964	active site
101510020965	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510020966	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510020967	active site
101510020968	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
101510020969	classical (c) SDRs; Region: SDR_c; cd05233
101510020970	NAD(P) binding site [chemical binding]; other site
101510020971	active site
101510020972	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
101510020973	Helix-turn-helix domains; Region: HTH; cl00088
101510020974	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
101510020975	Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173
101510020976	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
101510020977	putative active site [active]
101510020978	putative substrate binding site [chemical binding]; other site
101510020979	ATP binding site [chemical binding]; other site
101510020980	putative transposase OrfB; Reviewed; Region: PHA02517
101510020981	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510020982	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510020983	active site
101510020984	ATP binding site [chemical binding]; other site
101510020985	substrate binding site [chemical binding]; other site
101510020986	activation loop (A-loop); other site
101510020987	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510020988	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510020989	DNA binding residues [nucleotide binding]
101510020990	dimerization interface [polypeptide binding]; other site
101510020991	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
101510020992	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH9; cd08269
101510020993	putative NAD(P) binding site [chemical binding]; other site
101510020994	catalytic Zn binding site [ion binding]; other site
101510020995	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
101510020996	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
101510020997	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
101510020998	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
101510020999	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510021000	putative substrate translocation pore; other site
101510021001	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
101510021002	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510021003	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510021004	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
101510021005	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
101510021006	Lsr2; Region: Lsr2; pfam11774
101510021007	Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117
101510021008	homodimer interface [polypeptide binding]; other site
101510021009	putative active site [active]
101510021010	catalytic site [active]
101510021011	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
101510021012	Transposase, Mutator family; Region: Transposase_mut; pfam00872
101510021013	MULE transposase domain; Region: MULE; pfam10551
101510021014	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510021015	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510021016	active site
101510021017	ATP binding site [chemical binding]; other site
101510021018	substrate binding site [chemical binding]; other site
101510021019	activation loop (A-loop); other site
101510021020	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
101510021021	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510021022	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510021023	DNA binding residues [nucleotide binding]
101510021024	dimerization interface [polypeptide binding]; other site
101510021025	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
101510021026	RES domain; Region: RES; cl02411
101510021027	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
101510021028	Sodium:solute symporter family; Region: SSF; cl00456
101510021029	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
101510021030	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
101510021031	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
101510021032	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
101510021033	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
101510021034	carboxyltransferase (CT) interaction site; other site
101510021035	biotinylation site [posttranslational modification]; other site
101510021036	LamB/YcsF family; Region: LamB_YcsF; cl00664
101510021037	acyl-CoA synthetase; Validated; Region: PRK08162
101510021038	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510021039	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510021040	Putative cyclase; Region: Cyclase; cl00814
101510021041	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
101510021042	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510021043	DNA-binding site [nucleotide binding]; DNA binding site
101510021044	UTRA domain; Region: UTRA; cl01230
101510021045	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
101510021046	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
101510021047	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
101510021048	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
101510021049	PAS fold; Region: PAS_4; pfam08448
101510021050	Protein of unknown function (DUF2899); Region: DUF2899; pfam11449
101510021051	Protein of unknown function (DUF2899); Region: DUF2899; pfam11449
101510021052	hypothetical protein; Provisional; Region: PRK06149
101510021053	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
101510021054	active site
101510021055	ATP binding site [chemical binding]; other site
101510021056	substrate binding site [chemical binding]; other site
101510021057	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
101510021058	putative catalytic cysteine [active]
101510021059	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
101510021060	Hexamer interface [polypeptide binding]; other site
101510021061	Hexagonal pore residue; other site
101510021062	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052
101510021063	putative hexamer interface [polypeptide binding]; other site
101510021064	putative hexagonal pore; other site
101510021065	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
101510021066	Hexamer/Pentamer interface [polypeptide binding]; other site
101510021067	central pore; other site
101510021068	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
101510021069	Hexamer interface [polypeptide binding]; other site
101510021070	Hexagonal pore residue; other site
101510021071	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051
101510021072	putative hexamer interface [polypeptide binding]; other site
101510021073	putative hexagonal pore; other site
101510021074	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052
101510021075	putative hexamer interface [polypeptide binding]; other site
101510021076	putative hexagonal pore; other site
101510021077	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
101510021078	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
101510021079	inhibitor-cofactor binding pocket; inhibition site
101510021080	pyridoxal 5'-phosphate binding site [chemical binding]; other site
101510021081	catalytic residue [active]
101510021082	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
101510021083	Hexamer interface [polypeptide binding]; other site
101510021084	Hexagonal pore residue; other site
101510021085	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052
101510021086	putative hexamer interface [polypeptide binding]; other site
101510021087	putative hexagonal pore; other site
101510021088	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
101510021089	Hexamer/Pentamer interface [polypeptide binding]; other site
101510021090	central pore; other site
101510021091	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
101510021092	Hexamer interface [polypeptide binding]; other site
101510021093	Hexagonal pore residue; other site
101510021094	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
101510021095	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510021096	DNA-binding site [nucleotide binding]; DNA binding site
101510021097	UTRA domain; Region: UTRA; cl01230
101510021098	enoyl-CoA hydratase; Provisional; Region: PRK06213
101510021099	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510021100	substrate binding site [chemical binding]; other site
101510021101	oxyanion hole (OAH) forming residues; other site
101510021102	trimer interface [polypeptide binding]; other site
101510021103	ethanolamine permease; Region: 2A0305; TIGR00908
101510021104	Amino acid permease; Region: AA_permease; cl00524
101510021105	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
101510021106	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
101510021107	conserved cys residue [active]
101510021108	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
101510021109	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
101510021110	catalytic triad [active]
101510021111	conserved cis-peptide bond; other site
101510021112	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
101510021113	conserved cis-peptide bond; other site
101510021114	Transcriptional regulator [Transcription]; Region: LysR; COG0583
101510021115	Helix-turn-helix domains; Region: HTH; cl00088
101510021116	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
101510021117	putative dimerization interface [polypeptide binding]; other site
101510021118	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
101510021119	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
101510021120	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
101510021121	active site
101510021122	Creatinine amidohydrolase; Region: Creatininase; cl00618
101510021123	metabolite-proton symporter; Region: 2A0106; TIGR00883
101510021124	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510021125	putative substrate translocation pore; other site
101510021126	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
101510021127	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
101510021128	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
101510021129	catalytic residue [active]
101510021130	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
101510021131	homotrimer interaction site [polypeptide binding]; other site
101510021132	putative active site [active]
101510021133	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510021134	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
101510021135	Domain of unknown function (DUF4379); Region: DUF4379; pfam14311
101510021136	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
101510021137	Active Sites [active]
101510021138	Domain of unknown function (DUF3846); Region: DUF3846; pfam12957
101510021139	CRISPR/Cas system-associated RAMP superfamily protein Csf3; Region: Csf3_U; cl11865
101510021140	CRISPR/Cas system-associated RAMP superfamily protein Csf2; Region: Csf2_U; cl11864
101510021141	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
101510021142	Active Sites [active]
101510021143	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
101510021144	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
101510021145	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
101510021146	Domain of unknown function (DUF4379); Region: DUF4379; pfam14311
101510021147	Helix-turn-helix domains; Region: HTH; cl00088
101510021148	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
101510021149	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510021150	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510021151	active site
101510021152	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
101510021153	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510021154	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510021155	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
101510021156	putative transposase OrfB; Reviewed; Region: PHA02517
101510021157	Integrase core domain; Region: rve; cl01316
101510021158	Helix-turn-helix domains; Region: HTH; cl00088
101510021159	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614
101510021160	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
101510021161	NAD(P) binding site [chemical binding]; other site
101510021162	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
101510021163	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
101510021164	E3 interaction surface; other site
101510021165	lipoyl attachment site [posttranslational modification]; other site
101510021166	e3 binding domain; Region: E3_binding; pfam02817
101510021167	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
101510021168	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
101510021169	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
101510021170	alpha subunit interface [polypeptide binding]; other site
101510021171	TPP binding site [chemical binding]; other site
101510021172	heterodimer interface [polypeptide binding]; other site
101510021173	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
101510021174	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
101510021175	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
101510021176	tetramer interface [polypeptide binding]; other site
101510021177	TPP-binding site [chemical binding]; other site
101510021178	heterodimer interface [polypeptide binding]; other site
101510021179	phosphorylation loop region [posttranslational modification]
101510021180	isovaleryl-CoA dehydrogenase; Region: PLN02519
101510021181	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510021182	active site
101510021183	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510021184	Helix-turn-helix domains; Region: HTH; cl00088
101510021185	GAF domain; Region: GAF; cl00853
101510021186	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
101510021187	enoyl-CoA hydratase; Provisional; Region: PRK06688
101510021188	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510021189	substrate binding site [chemical binding]; other site
101510021190	oxyanion hole (OAH) forming residues; other site
101510021191	trimer interface [polypeptide binding]; other site
101510021192	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
101510021193	human dehydrogenase/reductase (SDR family) member 1 (DHRS1) and human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: DHRS1_HSDL2-like_SDR_c; cd05338
101510021194	NAD(P) binding site [chemical binding]; other site
101510021195	homodimer interface [polypeptide binding]; other site
101510021196	active site
101510021197	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510021198	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
101510021199	FO synthase; Reviewed; Region: fbiC; PRK09234
101510021200	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
101510021201	FeS/SAM binding site; other site
101510021202	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
101510021203	FeS/SAM binding site; other site
101510021204	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
101510021205	classical (c) SDRs; Region: SDR_c; cd05233
101510021206	NAD(P) binding site [chemical binding]; other site
101510021207	active site
101510021208	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510021209	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
101510021210	Flavin Reductases; Region: FlaRed; cl00801
101510021211	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
101510021212	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522
101510021213	dimerization interface [polypeptide binding]; other site
101510021214	active site
101510021215	Domain of unknown function (DUF385); Region: DUF385; cl04387
101510021216	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510021217	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
101510021218	DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388
101510021219	Helix-turn-helix domains; Region: HTH; cl00088
101510021220	Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106
101510021221	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510021222	NAD(P) binding site [chemical binding]; other site
101510021223	catalytic residues [active]
101510021224	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510021225	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510021226	active site
101510021227	ATP binding site [chemical binding]; other site
101510021228	substrate binding site [chemical binding]; other site
101510021229	activation loop (A-loop); other site
101510021230	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510021231	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510021232	DNA binding residues [nucleotide binding]
101510021233	dimerization interface [polypeptide binding]; other site
101510021234	Helix-turn-helix domains; Region: HTH; cl00088
101510021235	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
101510021236	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510021237	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490
101510021238	glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554
101510021239	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510021240	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
101510021241	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
101510021242	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
101510021243	active site
101510021244	dimer interface [polypeptide binding]; other site
101510021245	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
101510021246	dimer interface [polypeptide binding]; other site
101510021247	active site
101510021248	Transcription factor WhiB; Region: Whib; pfam02467
101510021249	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
101510021250	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510021251	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
101510021252	Cytochrome P450; Region: p450; cl12078
101510021253	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510021254	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130
101510021255	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
101510021256	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
101510021257	active site
101510021258	catalytic triad [active]
101510021259	ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]; Region: RPT1; COG1222
101510021260	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
101510021261	Walker A motif; other site
101510021262	ATP binding site [chemical binding]; other site
101510021263	Walker B motif; other site
101510021264	arginine finger; other site
101510021265	Phosphopantetheine attachment site; Region: PP-binding; cl09936
101510021266	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
101510021267	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358
101510021268	Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117
101510021269	homodimer interface [polypeptide binding]; other site
101510021270	putative active site [active]
101510021271	catalytic site [active]
101510021272	Lsr2; Region: Lsr2; pfam11774
101510021273	Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15375
101510021274	Lsr2; Region: Lsr2; pfam11774
101510021275	Lsr2; Region: Lsr2; pfam11774
101510021276	Lsr2; Region: Lsr2; pfam11774
101510021277	glycoprotein BALF4; Provisional; Region: PHA03231
101510021278	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
101510021279	nucleophile elbow; other site
101510021280	Transposase, Mutator family; Region: Transposase_mut; pfam00872
101510021281	MULE transposase domain; Region: MULE; pfam10551
101510021282	Helix-turn-helix domains; Region: HTH; cl00088
101510021283	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
101510021284	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
101510021285	phosphopeptide binding site; other site
101510021286	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296
101510021287	putative active site [active]
101510021288	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
101510021289	phosphopeptide binding site; other site
101510021290	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
101510021291	ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR).  DR is a well-described phenomenon occurring in fungi and shares several similarities with processes...; Region: ABCG_EPDR; cd03213
101510021292	Walker A/P-loop; other site
101510021293	ATP binding site [chemical binding]; other site
101510021294	Q-loop/lid; other site
101510021295	ABC transporter signature motif; other site
101510021296	Walker B; other site
101510021297	D-loop; other site
101510021298	H-loop/switch region; other site
101510021299	ABC-2 type transporter; Region: ABC2_membrane; cl11417
101510021300	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510021301	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510021302	active site
101510021303	ATP binding site [chemical binding]; other site
101510021304	substrate binding site [chemical binding]; other site
101510021305	activation loop (A-loop); other site
101510021306	Helix-turn-helix domains; Region: HTH; cl00088
101510021307	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
101510021308	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510021309	active site
101510021310	ATP binding site [chemical binding]; other site
101510021311	substrate binding site [chemical binding]; other site
101510021312	activation loop (A-loop); other site
101510021313	Uncharacterized conserved protein [Function unknown]; Region: COG3391
101510021314	NHL repeat; Region: NHL; pfam01436
101510021315	NHL repeat; Region: NHL; pfam01436
101510021316	NHL repeat; Region: NHL; pfam01436
101510021317	Protein of unknown function (DUF732); Region: DUF732; pfam05305
101510021318	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
101510021319	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
101510021320	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510021321	homoserine O-acetyltransferase; Provisional; Region: metX; cl15472
101510021322	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
101510021323	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
101510021324	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
101510021325	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
101510021326	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510021327	Integrase core domain; Region: rve; cl01316
101510021328	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
101510021329	Helix-turn-helix domains; Region: HTH; cl00088
101510021330	Integrase core domain; Region: rve; cl01316
101510021331	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
101510021332	active site
101510021333	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
101510021334	DNA binding site [nucleotide binding]
101510021335	Uncharacterised ACR, COG2135; Region: DUF159; cl03646
101510021336	Transposase; Region: DEDD_Tnp_IS110; pfam01548
101510021337	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
101510021338	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
101510021339	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
101510021340	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
101510021341	ParB-like nuclease domain; Region: ParBc; cl02129
101510021342	LGFP repeat; Region: LGFP; pfam08310
101510021343	LGFP repeat; Region: LGFP; pfam08310
101510021344	LGFP repeat; Region: LGFP; pfam08310
101510021345	LGFP repeat; Region: LGFP; pfam08310
101510021346	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
101510021347	Phage integrase family; Region: Phage_integrase; pfam00589
101510021348	DNA binding site [nucleotide binding]
101510021349	Int/Topo IB signature motif; other site
101510021350	active site
101510021351	catalytic residues [active]
101510021352	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
101510021353	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
101510021354	DNA binding site [nucleotide binding]
101510021355	Int/Topo IB signature motif; other site
101510021356	active site
101510021357	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
101510021358	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
101510021359	active site
101510021360	DNA binding site [nucleotide binding]
101510021361	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
101510021362	DNA binding site [nucleotide binding]
101510021363	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
101510021364	HsdM N-terminal domain; Region: HsdM_N; pfam12161
101510021365	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
101510021366	S-adenosylmethionine binding site [chemical binding]; other site
101510021367	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
101510021368	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
101510021369	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
101510021370	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
101510021371	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
101510021372	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510021373	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
101510021374	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
101510021375	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510021376	ABC transporter signature motif; other site
101510021377	Walker B; other site
101510021378	D-loop; other site
101510021379	H-loop/switch region; other site
101510021380	Helix-turn-helix domains; Region: HTH; cl00088
101510021381	putative transposase OrfB; Reviewed; Region: PHA02517
101510021382	putative transposase OrfB; Reviewed; Region: PHA02517
101510021383	Transcription factor WhiB; Region: Whib; pfam02467
101510021384	acyl-CoA synthetase; Validated; Region: PRK08162
101510021385	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510021386	YCII-related domain; Region: YCII; cl00999
101510021387	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
101510021388	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
101510021389	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510021390	classical (c) SDRs; Region: SDR_c; cd05233
101510021391	NAD(P) binding site [chemical binding]; other site
101510021392	active site
101510021393	Cupin domain; Region: Cupin_2; cl09118
101510021394	Cupin domain; Region: Cupin_2; cl09118
101510021395	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
101510021396	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
101510021397	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510021398	glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554
101510021399	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
101510021400	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
101510021401	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
101510021402	active site
101510021403	dimer interface [polypeptide binding]; other site
101510021404	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
101510021405	dimer interface [polypeptide binding]; other site
101510021406	active site
101510021407	acyl-CoA synthetase; Validated; Region: PRK07470
101510021408	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510021409	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
101510021410	classical (c) SDRs; Region: SDR_c; cd05233
101510021411	NAD(P) binding site [chemical binding]; other site
101510021412	active site
101510021413	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
101510021414	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
101510021415	NAD binding site [chemical binding]; other site
101510021416	catalytic Zn binding site [ion binding]; other site
101510021417	substrate binding site [chemical binding]; other site
101510021418	structural Zn binding site [ion binding]; other site
101510021419	hypothetical protein; Provisional; Region: PRK06126
101510021420	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510021421	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510021422	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510021423	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
101510021424	putative substrate translocation pore; other site
101510021425	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
101510021426	TM-ABC transporter signature motif; other site
101510021427	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
101510021428	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
101510021429	Walker A/P-loop; other site
101510021430	ATP binding site [chemical binding]; other site
101510021431	Q-loop/lid; other site
101510021432	ABC transporter signature motif; other site
101510021433	Walker B; other site
101510021434	D-loop; other site
101510021435	H-loop/switch region; other site
101510021436	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
101510021437	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
101510021438	ligand binding site [chemical binding]; other site
101510021439	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
101510021440	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
101510021441	NAD binding site [chemical binding]; other site
101510021442	catalytic residues [active]
101510021443	DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975
101510021444	Helix-turn-helix domains; Region: HTH; cl00088
101510021445	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
101510021446	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
101510021447	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
101510021448	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510021449	NAD(P) binding site [chemical binding]; other site
101510021450	active site
101510021451	dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396
101510021452	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510021453	substrate binding site [chemical binding]; other site
101510021454	oxyanion hole (OAH) forming residues; other site
101510021455	trimer interface [polypeptide binding]; other site
101510021456	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
101510021457	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
101510021458	substrate binding site [chemical binding]; other site
101510021459	oxyanion hole (OAH) forming residues; other site
101510021460	trimer interface [polypeptide binding]; other site
101510021461	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510021462	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510021463	active site
101510021464	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
101510021465	DUF35 OB-fold domain; Region: DUF35; pfam01796
101510021466	acetyl-CoA acetyltransferase; Provisional; Region: PRK06064
101510021467	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
101510021468	active site
101510021469	Transcriptional regulators [Transcription]; Region: GntR; COG1802
101510021470	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
101510021471	DNA-binding site [nucleotide binding]; DNA binding site
101510021472	FCD domain; Region: FCD; cl11656
101510021473	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
101510021474	CoA-transferase family III; Region: CoA_transf_3; pfam02515
101510021475	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
101510021476	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510021477	acetyl-CoA synthetase; Provisional; Region: PRK00174
101510021478	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
101510021479	Acyl-protein synthetase, LuxE; Region: LuxE; cl15695
101510021480	multiple promoter invertase; Provisional; Region: mpi; PRK13413
101510021481	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
101510021482	catalytic residues [active]
101510021483	catalytic nucleophile [active]
101510021484	Presynaptic Site I dimer interface [polypeptide binding]; other site
101510021485	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
101510021486	Synaptic Flat tetramer interface [polypeptide binding]; other site
101510021487	Synaptic Site I dimer interface [polypeptide binding]; other site
101510021488	DNA binding site [nucleotide binding]
101510021489	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
101510021490	DNA-binding interface [nucleotide binding]; DNA binding site
101510021491	Clp amino terminal domain; Region: Clp_N; pfam02861
101510021492	Clp amino terminal domain; Region: Clp_N; pfam02861
101510021493	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
101510021494	Helix-turn-helix domains; Region: HTH; cl00088
101510021495	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011
101510021496	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424
101510021497	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
101510021498	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
101510021499	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
101510021500	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
101510021501	Predicted membrane protein (DUF2078); Region: DUF2078; cl01373
101510021502	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
101510021503	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
101510021504	active site
101510021505	phosphorylation site [posttranslational modification]
101510021506	intermolecular recognition site; other site
101510021507	dimerization interface [polypeptide binding]; other site
101510021508	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
101510021509	DNA binding site [nucleotide binding]
101510021510	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
101510021511	dimer interface [polypeptide binding]; other site
101510021512	phosphorylation site [posttranslational modification]
101510021513	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
101510021514	ATP binding site [chemical binding]; other site
101510021515	Mg2+ binding site [ion binding]; other site
101510021516	G-X-G motif; other site
101510021517	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
101510021518	metal-binding site [ion binding]
101510021519	Domain of unknown function (DUF305); Region: DUF305; pfam03713
101510021520	Domain of unknown function (DUF305); Region: DUF305; pfam03713
101510021521	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
101510021522	putative homotetramer interface [polypeptide binding]; other site
101510021523	putative homodimer interface [polypeptide binding]; other site
101510021524	putative allosteric switch controlling residues; other site
101510021525	putative metal binding site [ion binding]; other site
101510021526	putative homodimer-homodimer interface [polypeptide binding]; other site
101510021527	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
101510021528	metal-binding site [ion binding]
101510021529	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
101510021530	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
101510021531	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
101510021532	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
101510021533	metal-binding site [ion binding]
101510021534	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
101510021535	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
101510021536	metal-binding site [ion binding]
101510021537	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
101510021538	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
101510021539	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
101510021540	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510021541	Walker A/P-loop; other site
101510021542	ATP binding site [chemical binding]; other site
101510021543	Q-loop/lid; other site
101510021544	ABC transporter signature motif; other site
101510021545	Walker B; other site
101510021546	D-loop; other site
101510021547	H-loop/switch region; other site
101510021548	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
101510021549	hydrophobic ligand binding site; other site
101510021550	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
101510021551	Major Facilitator Superfamily; Region: MFS_1; pfam07690
101510021552	putative substrate translocation pore; other site
101510021553	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
101510021554	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510021555	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
101510021556	active site residue [active]
101510021557	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
101510021558	active site residue [active]
101510021559	Helix-turn-helix domains; Region: HTH; cl00088
101510021560	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
101510021561	active site residue [active]
101510021562	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
101510021563	phosphopeptide binding site; other site
101510021564	Domain of unknown function DUF59; Region: DUF59; cl00941
101510021565	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
101510021566	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
101510021567	Walker A motif; other site
101510021568	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
101510021569	molybdopterin cofactor binding site; other site
101510021570	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
101510021571	putative molybdopterin cofactor binding site; other site
101510021572	tetrathionate reductase subunit B; Provisional; Region: PRK14993
101510021573	4Fe-4S binding domain; Region: Fer4; cl02805
101510021574	Polysulphide reductase, NrfD; Region: NrfD; cl01295
101510021575	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
101510021576	CPxP  motif; other site
101510021577	DsrE/DsrF-like family; Region: DrsE; cl00672
101510021578	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
101510021579	active site residue [active]
101510021580	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
101510021581	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510021582	Domain of unknown function DUF; Region: DUF202; cl09954
101510021583	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
101510021584	dimerization interface [polypeptide binding]; other site
101510021585	putative DNA binding site [nucleotide binding]; other site
101510021586	putative Zn2+ binding site [ion binding]; other site
101510021587	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510021588	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
101510021589	active site residue [active]
101510021590	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
101510021591	active site residue [active]
101510021592	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
101510021593	catalytic residues [active]
101510021594	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
101510021595	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
101510021596	active site residue [active]
101510021597	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
101510021598	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
101510021599	putative homotetramer interface [polypeptide binding]; other site
101510021600	putative homodimer interface [polypeptide binding]; other site
101510021601	putative allosteric switch controlling residues; other site
101510021602	putative metal binding site [ion binding]; other site
101510021603	putative homodimer-homodimer interface [polypeptide binding]; other site
101510021604	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
101510021605	Domain of unknown function DUF302; Region: DUF302; cl01364
101510021606	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
101510021607	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
101510021608	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
101510021609	active site residue [active]
101510021610	putative transporter; Provisional; Region: PRK11660
101510021611	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274
101510021612	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
101510021613	putative NAD(P) binding site [chemical binding]; other site
101510021614	Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117
101510021615	homodimer interface [polypeptide binding]; other site
101510021616	putative active site [active]
101510021617	catalytic site [active]
101510021618	Protein of unknown function (DUF2637); Region: DUF2637; pfam10935
101510021619	ribonuclease E; Reviewed; Region: rne; PRK10811
101510021620	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
101510021621	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
101510021622	P-loop; other site
101510021623	Magnesium ion binding site [ion binding]; other site
101510021624	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
101510021625	Magnesium ion binding site [ion binding]; other site
101510021626	Transposase, Mutator family; Region: Transposase_mut; pfam00872
101510021627	MULE transposase domain; Region: MULE; pfam10551
101510021628	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
101510021629	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
101510021630	non-specific DNA binding site [nucleotide binding]; other site
101510021631	salt bridge; other site
101510021632	sequence-specific DNA binding site [nucleotide binding]; other site
101510021633	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
101510021634	salt bridge; other site
101510021635	non-specific DNA binding site [nucleotide binding]; other site
101510021636	sequence-specific DNA binding site [nucleotide binding]; other site
101510021637	Intracellular septation protein A; Region: IspA; cl01098
101510021638	Cytochrome P450; Region: p450; cl12078
101510021639	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
101510021640	Helix-turn-helix domains; Region: HTH; cl00088
101510021641	Helix-turn-helix domains; Region: HTH; cl00088
101510021642	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510021643	Integrase core domain; Region: rve; cl01316
101510021644	Peptidase family M23; Region: Peptidase_M23; pfam01551
101510021645	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
101510021646	N-acetyl-D-glucosamine binding site [chemical binding]; other site
101510021647	catalytic residue [active]
101510021648	NlpC/P60 family; Region: NLPC_P60; cl11438
101510021649	AAA-like domain; Region: AAA_10; pfam12846
101510021650	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510021651	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951
101510021652	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
101510021653	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510021654	Cutinase; Region: Cutinase; cl15711
101510021655	N-formylglutamate amidohydrolase; Region: FGase; cl01522
101510021656	ATP-dependent helicase HepA; Validated; Region: PRK04914
101510021657	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
101510021658	ATP binding site [chemical binding]; other site
101510021659	Catalytic domain of Protein Kinases; Region: PKc; cd00180
101510021660	active site
101510021661	ATP binding site [chemical binding]; other site
101510021662	substrate binding site [chemical binding]; other site
101510021663	activation loop (A-loop); other site
101510021664	acyl-CoA thioesterase family protein; Region: PLN02868
101510021665	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
101510021666	Stress responsive A/B Barrel Domain; Region: Dabb; cl06768
101510021667	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
101510021668	Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177
101510021669	active site
101510021670	dimer interface [polypeptide binding]; other site
101510021671	metal binding site [ion binding]; metal-binding site
101510021672	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl01383
101510021673	chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465
101510021674	active site
101510021675	Flavin Reductases; Region: FlaRed; cl00801
101510021676	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
101510021677	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
101510021678	active site
101510021679	Helix-turn-helix domain; Region: HTH_18; pfam12833
101510021680	Transcription factor WhiB; Region: Whib; pfam02467
101510021681	Malic enzyme, N-terminal domain; Region: malic; pfam00390
101510021682	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
101510021683	putative NAD(P) binding site [chemical binding]; other site
101510021684	Helix-turn-helix domain; Region: HTH_18; pfam12833
101510021685	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
101510021686	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
101510021687	FMN-binding pocket [chemical binding]; other site
101510021688	flavin binding motif; other site
101510021689	phosphate binding motif [ion binding]; other site
101510021690	beta-alpha-beta structure motif; other site
101510021691	NAD binding pocket [chemical binding]; other site
101510021692	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
101510021693	catalytic loop [active]
101510021694	iron binding site [ion binding]; other site
101510021695	Cytochrome P450; Region: p450; cl12078
101510021696	EthD protein; Region: EthD; cl06234
101510021697	Chlorite dismutase; Region: Chlor_dismutase; cl01280
101510021698	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
101510021699	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
101510021700	active site
101510021701	dimer interface [polypeptide binding]; other site
101510021702	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
101510021703	dimer interface [polypeptide binding]; other site
101510021704	active site
101510021705	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490
101510021706	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
101510021707	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
101510021708	phosphate binding site [ion binding]; other site
101510021709	Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane]; Region: GutQ; COG0794
101510021710	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
101510021711	tetramer interface [polypeptide binding]; other site
101510021712	active site
101510021713	sensor protein BasS/PmrB; Provisional; Region: PRK10755
101510021714	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
101510021715	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
101510021716	DNA binding residues [nucleotide binding]
101510021717	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
101510021718	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
101510021719	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
101510021720	PhoU domain; Region: PhoU; pfam01895
101510021721	Clp protease ATP binding subunit; Region: clpC; CHL00095
101510021722	Clp amino terminal domain; Region: Clp_N; pfam02861