-- dump date   	20120504_160249
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
648757000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
648757000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
648757000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
648757000004	Walker A motif; other site
648757000005	ATP binding site [chemical binding]; other site
648757000006	Walker B motif; other site
648757000007	arginine finger; other site
648757000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
648757000009	DnaA box-binding interface [nucleotide binding]; other site
648757000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
648757000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
648757000012	putative DNA binding surface [nucleotide binding]; other site
648757000013	dimer interface [polypeptide binding]; other site
648757000014	beta-clamp/clamp loader binding surface; other site
648757000015	beta-clamp/translesion DNA polymerase binding surface; other site
648757000016	recombination protein F; Reviewed; Region: recF; PRK00064
648757000017	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757000018	Walker A/P-loop; other site
648757000019	ATP binding site [chemical binding]; other site
648757000020	Q-loop/lid; other site
648757000021	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757000022	ABC transporter signature motif; other site
648757000023	Walker B; other site
648757000024	D-loop; other site
648757000025	H-loop/switch region; other site
648757000026	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
648757000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757000028	Mg2+ binding site [ion binding]; other site
648757000029	G-X-G motif; other site
648757000030	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
648757000031	anchoring element; other site
648757000032	dimer interface [polypeptide binding]; other site
648757000033	ATP binding site [chemical binding]; other site
648757000034	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
648757000035	active site
648757000036	putative metal-binding site [ion binding]; other site
648757000037	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
648757000038	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
648757000039	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
648757000040	hexamer interface [polypeptide binding]; other site
648757000041	metal binding site [ion binding]; metal-binding site
648757000042	substrate binding site [chemical binding]; other site
648757000043	probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880
648757000044	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
648757000045	Walker A motif; other site
648757000046	ATP binding site [chemical binding]; other site
648757000047	Walker B motif; other site
648757000048	arginine finger; other site
648757000049	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
648757000050	multimerization interface [polypeptide binding]; other site
648757000051	ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208
648757000052	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
648757000053	homodimer interface [polypeptide binding]; other site
648757000054	active site
648757000055	heterodimer interface [polypeptide binding]; other site
648757000056	catalytic residue [active]
648757000057	metal binding site [ion binding]; metal-binding site
648757000058	transketolase; Reviewed; Region: PRK05899
648757000059	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
648757000060	TPP-binding site [chemical binding]; other site
648757000061	dimer interface [polypeptide binding]; other site
648757000062	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
648757000063	PYR/PP interface [polypeptide binding]; other site
648757000064	dimer interface [polypeptide binding]; other site
648757000065	TPP binding site [chemical binding]; other site
648757000066	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
648757000067	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757000068	active site
648757000069	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
648757000070	metal binding site [ion binding]; metal-binding site
648757000071	active site
648757000072	Helix-turn-helix domains; Region: HTH; cl00088
648757000073	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
648757000074	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
648757000075	putative dimerization interface [polypeptide binding]; other site
648757000076	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
648757000077	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
648757000078	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
648757000079	DNA binding site [nucleotide binding]
648757000080	active site
648757000081	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
648757000082	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
648757000083	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
648757000084	catalytic residue [active]
648757000085	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
648757000086	dimerization interface [polypeptide binding]; other site
648757000087	putative DNA binding site [nucleotide binding]; other site
648757000088	putative Zn2+ binding site [ion binding]; other site
648757000089	Methyltransferase domain; Region: Methyltransf_31; pfam13847
648757000090	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
648757000091	S-adenosylmethionine binding site [chemical binding]; other site
648757000092	Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219
648757000093	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
648757000094	FAD binding site [chemical binding]; other site
648757000095	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
648757000096	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
648757000097	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503
648757000098	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980
648757000099	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
648757000100	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
648757000101	NAD(P) binding site [chemical binding]; other site
648757000102	homotetramer interface [polypeptide binding]; other site
648757000103	homodimer interface [polypeptide binding]; other site
648757000104	active site
648757000105	putative acyltransferase; Provisional; Region: PRK05790
648757000106	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
648757000107	dimer interface [polypeptide binding]; other site
648757000108	active site
648757000109	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
648757000110	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
648757000111	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
648757000112	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757000113	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
648757000114	NAD(P) binding site [chemical binding]; other site
648757000115	active site
648757000116	Helix-turn-helix domains; Region: HTH; cl00088
648757000117	Winged helix-turn helix; Region: HTH_29; pfam13551
648757000118	Helix-turn-helix domains; Region: HTH; cl00088
648757000119	Integrase core domain; Region: rve; cl01316
648757000120	putative glycosyl transferase; Provisional; Region: PRK10307
648757000121	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
648757000122	Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003
648757000123	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
648757000124	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
648757000125	catalytic residue [active]
648757000126	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
648757000127	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
648757000128	tetramer interface [polypeptide binding]; other site
648757000129	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757000130	catalytic residue [active]
648757000131	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
648757000132	lipoyl attachment site [posttranslational modification]; other site
648757000133	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
648757000134	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
648757000135	6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254
648757000136	6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase; Region: dearomat_had; TIGR03201
648757000137	putative NAD(P) binding site [chemical binding]; other site
648757000138	catalytic Zn binding site [ion binding]; other site
648757000139	structural Zn binding site [ion binding]; other site
648757000140	6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase; Region: dearomat_oah; TIGR03200
648757000141	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
648757000142	substrate binding site [chemical binding]; other site
648757000143	oxyanion hole (OAH) forming residues; other site
648757000144	trimer interface [polypeptide binding]; other site
648757000145	cyclohexa-1,5-dienecarbonyl-CoA hydratase; Region: dienoyl_CoA_hyt; TIGR03189
648757000146	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
648757000147	substrate binding site [chemical binding]; other site
648757000148	oxyanion hole (OAH) forming residues; other site
648757000149	trimer interface [polypeptide binding]; other site
648757000150	benzoyl-CoA reductase, bzd-type, N subunit; Region: benz_CoA_bzdN; cl11464
648757000151	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
648757000152	benzoyl-CoA reductase, bzd-type, N subunit; Region: benz_CoA_bzdN; cl11464
648757000153	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
648757000154	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
648757000155	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
648757000156	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
648757000157	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757000158	NAD(P) binding site [chemical binding]; other site
648757000159	active site
648757000160	Rrf2 family protein; Region: rrf2_super; TIGR00738
648757000161	Helix-turn-helix domains; Region: HTH; cl00088
648757000162	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
648757000163	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
648757000164	Coenzyme A binding pocket [chemical binding]; other site
648757000165	benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262
648757000166	AMP-binding enzyme; Region: AMP-binding; cl15778
648757000167	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
648757000168	acetyl-CoA acetyltransferase; Provisional; Region: PRK08131
648757000169	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
648757000170	dimer interface [polypeptide binding]; other site
648757000171	active site
648757000172	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
648757000173	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
648757000174	Walker A/P-loop; other site
648757000175	ATP binding site [chemical binding]; other site
648757000176	Q-loop/lid; other site
648757000177	ABC transporter signature motif; other site
648757000178	Walker B; other site
648757000179	D-loop; other site
648757000180	H-loop/switch region; other site
648757000181	Cobalt transport protein; Region: CbiQ; cl00463
648757000182	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397
648757000183	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
648757000184	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
648757000185	nickel responsive regulator; Provisional; Region: PRK02967
648757000186	Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783
648757000187	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
648757000188	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
648757000189	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
648757000190	S-adenosylmethionine binding site [chemical binding]; other site
648757000191	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
648757000192	Protein of unknown function (DUF2497); Region: DUF2497; cl11534
648757000193	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
648757000194	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
648757000195	HIGH motif; other site
648757000196	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
648757000197	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
648757000198	active site
648757000199	KMSKS motif; other site
648757000200	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
648757000201	tRNA binding surface [nucleotide binding]; other site
648757000202	anticodon binding site; other site
648757000203	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
648757000204	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
648757000205	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
648757000206	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
648757000207	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
648757000208	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
648757000209	P-loop; other site
648757000210	Magnesium ion binding site [ion binding]; other site
648757000211	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757000212	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
648757000213	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
648757000214	DNA binding site [nucleotide binding]
648757000215	Int/Topo IB signature motif; other site
648757000216	active site
648757000217	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
648757000218	active site
648757000219	intersubunit interactions; other site
648757000220	catalytic residue [active]
648757000221	thiamine pyrophosphate protein; Validated; Region: PRK08199
648757000222	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
648757000223	PYR/PP interface [polypeptide binding]; other site
648757000224	dimer interface [polypeptide binding]; other site
648757000225	TPP binding site [chemical binding]; other site
648757000226	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
648757000227	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
648757000228	TPP-binding site [chemical binding]; other site
648757000229	Domain of unknown function (DUF336); Region: DUF336; cl01249
648757000230	Peptidase M15; Region: Peptidase_M15_3; cl01194
648757000231	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
648757000232	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
648757000233	active site
648757000234	Zn binding site [ion binding]; other site
648757000235	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
648757000236	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
648757000237	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
648757000238	RNase E interface [polypeptide binding]; other site
648757000239	trimer interface [polypeptide binding]; other site
648757000240	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
648757000241	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
648757000242	RNase E interface [polypeptide binding]; other site
648757000243	trimer interface [polypeptide binding]; other site
648757000244	active site
648757000245	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
648757000246	putative nucleic acid binding region [nucleotide binding]; other site
648757000247	G-X-X-G motif; other site
648757000248	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
648757000249	RNA binding site [nucleotide binding]; other site
648757000250	domain interface; other site
648757000251	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
648757000252	16S/18S rRNA binding site [nucleotide binding]; other site
648757000253	S13e-L30e interaction site [polypeptide binding]; other site
648757000254	25S rRNA binding site [nucleotide binding]; other site
648757000255	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
648757000256	PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573
648757000257	RNA binding site [nucleotide binding]; other site
648757000258	active site
648757000259	Ribosome-binding factor A; Region: RBFA; cl00542
648757000260	Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217
648757000261	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
648757000262	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
648757000263	active site
648757000264	HIGH motif; other site
648757000265	dimer interface [polypeptide binding]; other site
648757000266	KMSKS motif; other site
648757000267	Protein of unknown function; Region: DUF3971; pfam13116
648757000268	AsmA-like C-terminal region; Region: AsmA_2; cl15864
648757000269	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
648757000270	catalytic triad [active]
648757000271	AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911
648757000272	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
648757000273	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
648757000274	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
648757000275	RNA/DNA hybrid binding site [nucleotide binding]; other site
648757000276	active site
648757000277	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
648757000278	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
648757000279	FeS/SAM binding site; other site
648757000280	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
648757000281	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
648757000282	Probable Catalytic site; other site
648757000283	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
648757000284	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
648757000285	putative substrate translocation pore; other site
648757000286	Major Facilitator Superfamily; Region: MFS_1; pfam07690
648757000287	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
648757000288	nudix motif; other site
648757000289	Ferritin-like domain; Region: Ferritin; pfam00210
648757000290	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
648757000291	dimerization interface [polypeptide binding]; other site
648757000292	DPS ferroxidase diiron center [ion binding]; other site
648757000293	ion pore; other site
648757000294	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
648757000295	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
648757000296	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
648757000297	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
648757000298	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
648757000299	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
648757000300	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757000301	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
648757000302	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
648757000303	putative SdhC subunit interface [polypeptide binding]; other site
648757000304	putative proximal heme binding site [chemical binding]; other site
648757000305	putative Iron-sulfur protein interface [polypeptide binding]; other site
648757000306	putative proximal quinone binding site; other site
648757000307	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
648757000308	Iron-sulfur protein interface; other site
648757000309	proximal quinone binding site [chemical binding]; other site
648757000310	SdhD (CybS) interface [polypeptide binding]; other site
648757000311	proximal heme binding site [chemical binding]; other site
648757000312	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
648757000313	putative active site [active]
648757000314	putative catalytic site [active]
648757000315	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
648757000316	putative active site [active]
648757000317	putative catalytic site [active]
648757000318	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
648757000319	MoaE interaction surface [polypeptide binding]; other site
648757000320	MoeB interaction surface [polypeptide binding]; other site
648757000321	thiocarboxylated glycine; other site
648757000322	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
648757000323	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
648757000324	dimer interface [polypeptide binding]; other site
648757000325	motif 1; other site
648757000326	active site
648757000327	motif 2; other site
648757000328	motif 3; other site
648757000329	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
648757000330	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
648757000331	metal binding site [ion binding]; metal-binding site
648757000332	dimer interface [polypeptide binding]; other site
648757000333	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
648757000334	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
648757000335	GDP-binding site [chemical binding]; other site
648757000336	ACT binding site; other site
648757000337	IMP binding site; other site
648757000338	EamA-like transporter family; Region: EamA; cl01037
648757000339	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
648757000340	EamA-like transporter family; Region: EamA; cl01037
648757000341	Protein of unknown function (DUF466); Region: DUF466; cl01082
648757000342	carbon starvation protein A; Provisional; Region: PRK15015
648757000343	Carbon starvation protein CstA; Region: CstA; pfam02554
648757000344	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
648757000345	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
648757000346	MutS domain I; Region: MutS_I; pfam01624
648757000347	MutS domain II; Region: MutS_II; pfam05188
648757000348	MutS family domain IV; Region: MutS_IV; pfam05190
648757000349	MutS1 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284
648757000350	Walker A/P-loop; other site
648757000351	ATP binding site [chemical binding]; other site
648757000352	Q-loop/lid; other site
648757000353	ABC transporter signature motif; other site
648757000354	Walker B; other site
648757000355	D-loop; other site
648757000356	H-loop/switch region; other site
648757000357	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
648757000358	S-adenosylmethionine binding site [chemical binding]; other site
648757000359	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
648757000360	PAS domain; Region: PAS_9; pfam13426
648757000361	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
648757000362	Histidine kinase; Region: HisKA_2; cl06527
648757000363	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
648757000364	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
648757000365	Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599
648757000366	putative active site [active]
648757000367	putative catalytic site [active]
648757000368	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
648757000369	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757000370	cell division protein MraZ; Reviewed; Region: PRK00326
648757000371	MraZ protein; Region: MraZ; pfam02381
648757000372	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
648757000373	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
648757000374	AMP-binding enzyme; Region: AMP-binding; cl15778
648757000375	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
648757000376	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
648757000377	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
648757000378	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
648757000379	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
648757000380	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
648757000381	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757000382	Walker A/P-loop; other site
648757000383	ATP binding site [chemical binding]; other site
648757000384	Q-loop/lid; other site
648757000385	ABC transporter signature motif; other site
648757000386	Walker B; other site
648757000387	D-loop; other site
648757000388	H-loop/switch region; other site
648757000389	TOBE domain; Region: TOBE_2; cl01440
648757000390	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
648757000391	dimer interface [polypeptide binding]; other site
648757000392	conserved gate region; other site
648757000393	putative PBP binding loops; other site
648757000394	ABC-ATPase subunit interface; other site
648757000395	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
648757000396	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
648757000397	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656
648757000398	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
648757000399	TOBE domain; Region: TOBE_2; cl01440
648757000400	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
648757000401	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
648757000402	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
648757000403	AMP-binding enzyme; Region: AMP-binding; cl15778
648757000404	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
648757000405	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
648757000406	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
648757000407	heme binding pocket [chemical binding]; other site
648757000408	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
648757000409	domain interactions; other site
648757000410	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
648757000411	PPIC-type PPIASE domain; Region: Rotamase; cl08278
648757000412	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
648757000413	heterotetramer interface [polypeptide binding]; other site
648757000414	active site pocket [active]
648757000415	cleavage site
648757000416	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
648757000417	active site
648757000418	8-oxo-dGMP binding site [chemical binding]; other site
648757000419	nudix motif; other site
648757000420	metal binding site [ion binding]; metal-binding site
648757000421	LysE type translocator; Region: LysE; cl00565
648757000422	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
648757000423	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
648757000424	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901
648757000425	SEC-C motif; Region: SEC-C; pfam02810
648757000426	Transglycosylase SLT domain; Region: SLT_2; pfam13406
648757000427	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
648757000428	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
648757000429	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
648757000430	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
648757000431	ATP binding site [chemical binding]; other site
648757000432	substrate interface [chemical binding]; other site
648757000433	Predicted acetyltransferase [General function prediction only]; Region: COG3153
648757000434	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
648757000435	Coenzyme A binding pocket [chemical binding]; other site
648757000436	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388
648757000437	PAS domain; Region: PAS_5; pfam07310
648757000438	Predicted transcriptional regulator [Transcription]; Region: COG4957
648757000439	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
648757000440	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
648757000441	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
648757000442	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
648757000443	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
648757000444	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
648757000445	active site
648757000446	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
648757000447	catalytic triad [active]
648757000448	dimer interface [polypeptide binding]; other site
648757000449	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757000450	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333
648757000451	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
648757000452	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
648757000453	TPR repeat; Region: TPR_11; pfam13414
648757000454	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
648757000455	MG2 domain; Region: A2M_N; pfam01835
648757000456	Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703
648757000457	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
648757000458	surface patch; other site
648757000459	thioester region; other site
648757000460	specificity defining residues; other site
648757000461	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
648757000462	Transglycosylase; Region: Transgly; cl07896
648757000463	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
648757000464	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
648757000465	Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131
648757000466	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433
648757000467	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
648757000468	PAS fold; Region: PAS_3; pfam08447
648757000469	putative active site [active]
648757000470	heme pocket [chemical binding]; other site
648757000471	PAS domain S-box; Region: sensory_box; TIGR00229
648757000472	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
648757000473	putative active site [active]
648757000474	heme pocket [chemical binding]; other site
648757000475	sensory histidine kinase AtoS; Provisional; Region: PRK11360
648757000476	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
648757000477	dimer interface [polypeptide binding]; other site
648757000478	phosphorylation site [posttranslational modification]
648757000479	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757000480	ATP binding site [chemical binding]; other site
648757000481	Mg2+ binding site [ion binding]; other site
648757000482	G-X-G motif; other site
648757000483	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
648757000484	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757000485	active site
648757000486	phosphorylation site [posttranslational modification]
648757000487	intermolecular recognition site; other site
648757000488	dimerization interface [polypeptide binding]; other site
648757000489	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
648757000490	active site
648757000491	phosphorylation site [posttranslational modification]
648757000492	intermolecular recognition site; other site
648757000493	dimerization interface [polypeptide binding]; other site
648757000494	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
648757000495	substrate binding pocket [chemical binding]; other site
648757000496	chain length determination region; other site
648757000497	substrate-Mg2+ binding site; other site
648757000498	catalytic residues [active]
648757000499	aspartate-rich region 1; other site
648757000500	active site lid residues [active]
648757000501	aspartate-rich region 2; other site
648757000502	Transglycosylase; Region: Transgly; cl07896
648757000503	Ferredoxin [Energy production and conversion]; Region: COG1146
648757000504	4Fe-4S binding domain; Region: Fer4; cl02805
648757000505	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
648757000506	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
648757000507	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
648757000508	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
648757000509	RNA binding surface [nucleotide binding]; other site
648757000510	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757000511	lycopene cyclase family protein; Region: carotene-cycl; TIGR01790
648757000512	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
648757000513	active site lid residues [active]
648757000514	substrate binding pocket [chemical binding]; other site
648757000515	catalytic residues [active]
648757000516	substrate-Mg2+ binding site; other site
648757000517	aspartate-rich region 1; other site
648757000518	aspartate-rich region 2; other site
648757000519	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
648757000520	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
648757000521	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
648757000522	substrate binding pocket [chemical binding]; other site
648757000523	chain length determination region; other site
648757000524	substrate-Mg2+ binding site; other site
648757000525	catalytic residues [active]
648757000526	aspartate-rich region 1; other site
648757000527	active site lid residues [active]
648757000528	aspartate-rich region 2; other site
648757000529	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
648757000530	phytoene desaturase; Region: crtI_fam; TIGR02734
648757000531	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757000532	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757000533	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994
648757000534	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
648757000535	homodimer interface [polypeptide binding]; other site
648757000536	substrate-cofactor binding pocket; other site
648757000537	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757000538	catalytic residue [active]
648757000539	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
648757000540	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
648757000541	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757000542	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
648757000543	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
648757000544	malonyl-CoA binding site [chemical binding]; other site
648757000545	dimer interface [polypeptide binding]; other site
648757000546	active site
648757000547	product binding site; other site
648757000548	Transglycosylase SLT domain; Region: SLT_2; pfam13406
648757000549	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
648757000550	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
648757000551	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
648757000552	classical (c) SDRs; Region: SDR_c; cd05233
648757000553	NAD(P) binding site [chemical binding]; other site
648757000554	active site
648757000555	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
648757000556	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
648757000557	substrate binding pocket [chemical binding]; other site
648757000558	membrane-bound complex binding site; other site
648757000559	hinge residues; other site
648757000560	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
648757000561	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
648757000562	DXD motif; other site
648757000563	DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420
648757000564	AAA-like domain; Region: AAA_10; pfam12846
648757000565	Domain of unknown function DUF87; Region: DUF87; pfam01935
648757000566	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
648757000567	active site
648757000568	metal binding site [ion binding]; metal-binding site
648757000569	Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; cl09826
648757000570	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
648757000571	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
648757000572	Sel1 repeat; Region: Sel1; cl02723
648757000573	Sel1 repeat; Region: Sel1; cl02723
648757000574	Response regulator receiver domain; Region: Response_reg; pfam00072
648757000575	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757000576	active site
648757000577	phosphorylation site [posttranslational modification]
648757000578	intermolecular recognition site; other site
648757000579	dimerization interface [polypeptide binding]; other site
648757000580	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
648757000581	active site
648757000582	putative substrate binding region [chemical binding]; other site
648757000583	FOG: CBS domain [General function prediction only]; Region: COG0517
648757000584	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
648757000585	Isochorismatase family; Region: Isochorismatase; pfam00857
648757000586	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
648757000587	catalytic triad [active]
648757000588	conserved cis-peptide bond; other site
648757000589	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
648757000590	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
648757000591	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
648757000592	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
648757000593	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
648757000594	dimer interface [polypeptide binding]; other site
648757000595	putative functional site; other site
648757000596	putative MPT binding site; other site
648757000597	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
648757000598	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
648757000599	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
648757000600	putative NAD(P) binding site [chemical binding]; other site
648757000601	active site
648757000602	putative substrate binding site [chemical binding]; other site
648757000603	Helix-turn-helix domains; Region: HTH; cl00088
648757000604	Flavin Reductases; Region: FlaRed; cl00801
648757000605	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088
648757000606	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
648757000607	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
648757000608	Ribulose bisphosphate carboxylase like proteins (RLPs) similar to R.rubrum RLP; Region: RLP_RrRLP; cd08210
648757000609	dimer interface [polypeptide binding]; other site
648757000610	active site
648757000611	catalytic residue [active]
648757000612	metal binding site [ion binding]; metal-binding site
648757000613	Cupin domain; Region: Cupin_2; cl09118
648757000614	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
648757000615	TPR repeat; Region: TPR_11; pfam13414
648757000616	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
648757000617	binding surface
648757000618	TPR motif; other site
648757000619	TPR repeat; Region: TPR_11; pfam13414
648757000620	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
648757000621	binding surface
648757000622	TPR motif; other site
648757000623	TPR repeat; Region: TPR_11; pfam13414
648757000624	TPR repeat; Region: TPR_11; pfam13414
648757000625	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
648757000626	binding surface
648757000627	TPR motif; other site
648757000628	TPR repeat; Region: TPR_11; pfam13414
648757000629	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
648757000630	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
648757000631	MAPEG family; Region: MAPEG; cl09190
648757000632	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
648757000633	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
648757000634	DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420
648757000635	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757000636	polyphosphate kinase; Provisional; Region: PRK05443
648757000637	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
648757000638	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
648757000639	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
648757000640	putative domain interface [polypeptide binding]; other site
648757000641	putative active site [active]
648757000642	catalytic site [active]
648757000643	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
648757000644	putative active site [active]
648757000645	catalytic site [active]
648757000646	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
648757000647	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
648757000648	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
648757000649	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
648757000650	HSP70 interaction site [polypeptide binding]; other site
648757000651	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
648757000652	substrate binding site [polypeptide binding]; other site
648757000653	dimer interface [polypeptide binding]; other site
648757000654	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
648757000655	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
648757000656	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
648757000657	phytoene desaturase; Region: crtI_fam; TIGR02734
648757000658	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757000659	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
648757000660	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202
648757000661	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
648757000662	putative NAD(P) binding site [chemical binding]; other site
648757000663	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757000664	chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016
648757000665	chlorophyllide reductase subunit Y; Region: BchY; TIGR02015
648757000666	Chlide_reductase_Y : Y subunit of chlorophyllide (chlide) reductase (BchY).  Chlide reductase participates in photosynthetic pigment synthesis playing a role in the conversion of chlorophylls(Chl) into bacteriochlorophylls (BChl). Chlide reductase...; Region: Chlide_reductase_Y; cd01980
648757000667	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
648757000668	chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014
648757000669	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
648757000670	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
648757000671	Subunit L of bacterial photosynthetic reaction center; Region: Photo-RC_L; cd09290
648757000672	subunit M interface; other site
648757000673	subunit H interface; other site
648757000674	quinone binding site; other site
648757000675	bacteriopheophytin binding site; other site
648757000676	bacteriochlorophyll binding site; other site
648757000677	cytochrome C subunit interface; other site
648757000678	Fe binding site [ion binding]; other site
648757000679	Subunit M of bacterial photosynthetic reaction center; Region: Photo-RC_M; cd09291
648757000680	subunit H interface; other site
648757000681	subunit L interface; other site
648757000682	bacteriopheophytin binding site; other site
648757000683	carotenoid binding site; other site
648757000684	bacteriochlorophyll binding site; other site
648757000685	cytochrome C interface; other site
648757000686	quinone binding site; other site
648757000687	Fe binding site [ion binding]; other site
648757000688	Cytochrome C subunit of the bacterial photosynthetic reaction center; Region: CytoC_RC; cd09224
648757000689	subunit interface [polypeptide binding]; other site
648757000690	Heme binding sites [chemical binding]; other site
648757000691	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
648757000692	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757000693	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
648757000694	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
648757000695	Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893
648757000696	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
648757000697	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
648757000698	Substrate binding site; other site
648757000699	metal-binding site
648757000700	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
648757000701	homodimer interface [polypeptide binding]; other site
648757000702	substrate-cofactor binding pocket; other site
648757000703	catalytic residue [active]
648757000704	osmolarity response regulator; Provisional; Region: ompR; PRK09468
648757000705	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757000706	active site
648757000707	phosphorylation site [posttranslational modification]
648757000708	intermolecular recognition site; other site
648757000709	dimerization interface [polypeptide binding]; other site
648757000710	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
648757000711	DNA binding site [nucleotide binding]
648757000712	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
648757000713	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
648757000714	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
648757000715	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757000716	ATP binding site [chemical binding]; other site
648757000717	Mg2+ binding site [ion binding]; other site
648757000718	G-X-G motif; other site
648757000719	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
648757000720	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
648757000721	active site
648757000722	Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839
648757000723	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
648757000724	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
648757000725	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
648757000726	dimer interface [polypeptide binding]; other site
648757000727	phosphorylation site [posttranslational modification]
648757000728	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757000729	ATP binding site [chemical binding]; other site
648757000730	Mg2+ binding site [ion binding]; other site
648757000731	G-X-G motif; other site
648757000732	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
648757000733	GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051
648757000734	putative C-terminal domain interface [polypeptide binding]; other site
648757000735	putative GSH binding site (G-site) [chemical binding]; other site
648757000736	putative dimer interface [polypeptide binding]; other site
648757000737	C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182
648757000738	putative N-terminal domain interface [polypeptide binding]; other site
648757000739	putative dimer interface [polypeptide binding]; other site
648757000740	putative substrate binding pocket (H-site) [chemical binding]; other site
648757000741	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
648757000742	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
648757000743	Helix-turn-helix domains; Region: HTH; cl00088
648757000744	gamma-glutamyl kinase; Provisional; Region: PRK05429
648757000745	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
648757000746	nucleotide binding site [chemical binding]; other site
648757000747	homotetrameric interface [polypeptide binding]; other site
648757000748	putative phosphate binding site [ion binding]; other site
648757000749	putative allosteric binding site; other site
648757000750	PUA domain; Region: PUA; cl00607
648757000751	YcxB-like protein; Region: YcxB; pfam14317
648757000752	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
648757000753	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
648757000754	putative catalytic cysteine [active]
648757000755	Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057
648757000756	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
648757000757	active site
648757000758	(T/H)XGH motif; other site
648757000759	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
648757000760	active site
648757000761	Protein of unknown function (DUF1045); Region: DUF1045; cl15435
648757000762	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
648757000763	PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907
648757000764	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
648757000765	Cu(I) binding site [ion binding]; other site
648757000766	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
648757000767	dimer interface [polypeptide binding]; other site
648757000768	phosphorylation site [posttranslational modification]
648757000769	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757000770	ATP binding site [chemical binding]; other site
648757000771	Mg2+ binding site [ion binding]; other site
648757000772	G-X-G motif; other site
648757000773	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
648757000774	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757000775	active site
648757000776	phosphorylation site [posttranslational modification]
648757000777	intermolecular recognition site; other site
648757000778	dimerization interface [polypeptide binding]; other site
648757000779	Helix-turn-helix domains; Region: HTH; cl00088
648757000780	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
648757000781	nucleoside/Zn binding site; other site
648757000782	dimer interface [polypeptide binding]; other site
648757000783	catalytic motif [active]
648757000784	PseudoU_synth_RluB: Pseudouridine synthase, Escherichia coli RluB like. This group is comprised of bacterial and eukaryotic proteins similar to E. coli RluB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluB; cd02556
648757000785	pseudouridine synthase; Region: TIGR00093
648757000786	probable active site [active]
648757000787	transcription termination factor Rho; Provisional; Region: PRK12678
648757000788	transcription termination factor Rho; Provisional; Region: PRK12678
648757000789	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
648757000790	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
648757000791	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
648757000792	S-adenosylmethionine binding site [chemical binding]; other site
648757000793	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
648757000794	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
648757000795	Uncharacterized conserved protein [Function unknown]; Region: COG3743
648757000796	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
648757000797	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
648757000798	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
648757000799	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
648757000800	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
648757000801	Walker A/P-loop; other site
648757000802	ATP binding site [chemical binding]; other site
648757000803	Q-loop/lid; other site
648757000804	ABC transporter signature motif; other site
648757000805	Walker B; other site
648757000806	D-loop; other site
648757000807	H-loop/switch region; other site
648757000808	DevC protein; Region: devC; TIGR01185
648757000809	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
648757000810	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
648757000811	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
648757000812	Malic enzyme, N-terminal domain; Region: malic; pfam00390
648757000813	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
648757000814	putative NAD(P) binding site [chemical binding]; other site
648757000815	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
648757000816	Uncharacterized conserved protein [Function unknown]; Region: COG1262
648757000817	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
648757000818	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
648757000819	hypothetical protein; Provisional; Region: PRK12472
648757000820	Quinolinate synthetase A protein; Region: NadA; cl00420
648757000821	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757000822	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
648757000823	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
648757000824	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
648757000825	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757000826	Viral (Superfamily 1) RNA helicase; Region: Viral_helicase1; pfam01443
648757000827	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757000828	Family description; Region: UvrD_C_2; cl15862
648757000829	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
648757000830	putative active site [active]
648757000831	Protein of unknown function (DUF3320); Region: DUF3320; pfam11784
648757000832	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
648757000833	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
648757000834	putative phosphate binding site [ion binding]; other site
648757000835	putative catalytic site [active]
648757000836	active site
648757000837	metal binding site A [ion binding]; metal-binding site
648757000838	DNA binding site [nucleotide binding]
648757000839	putative AP binding site [nucleotide binding]; other site
648757000840	putative metal binding site B [ion binding]; other site
648757000841	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
648757000842	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
648757000843	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
648757000844	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
648757000845	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
648757000846	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243
648757000847	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
648757000848	S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401
648757000849	oligomerization interface [polypeptide binding]; other site
648757000850	active site
648757000851	NAD+ binding site [chemical binding]; other site
648757000852	hypothetical protein; Reviewed; Region: PRK00024
648757000853	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
648757000854	MPN+ (JAMM) motif; other site
648757000855	Zinc-binding site [ion binding]; other site
648757000856	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
648757000857	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
648757000858	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
648757000859	ATM1 is an ABC transporter that is expressed in the mitochondria.  Although the specific function of ATM1 is unknown, its disruption results in the accumulation of excess mitochondrial iron, loss of mitochondrial cytochromes, oxidative damage to...; Region: ABCC_ATM1_transporter; cd03253
648757000860	Walker A/P-loop; other site
648757000861	ATP binding site [chemical binding]; other site
648757000862	Q-loop/lid; other site
648757000863	ABC transporter signature motif; other site
648757000864	Walker B; other site
648757000865	D-loop; other site
648757000866	H-loop/switch region; other site
648757000867	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
648757000868	Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890
648757000869	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
648757000870	putative substrate translocation pore; other site
648757000871	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
648757000872	rRNA binding site [nucleotide binding]; other site
648757000873	predicted 30S ribosome binding site; other site
648757000874	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
648757000875	active site
648757000876	dimer interface [polypeptide binding]; other site
648757000877	Domain of unknown function (DUF329); Region: DUF329; cl01144
648757000878	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
648757000879	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
648757000880	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
648757000881	hydrogenase 4 subunit B; Validated; Region: PRK06521
648757000882	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
648757000883	NADH dehydrogenase; Region: NADHdh; cl00469
648757000884	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
648757000885	hydrogenase 4 subunit F; Validated; Region: PRK06458
648757000886	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
648757000887	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771
648757000888	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
648757000889	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
648757000890	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
648757000891	CPxP  motif; other site
648757000892	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
648757000893	putative MPT binding site; other site
648757000894	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
648757000895	active site
648757000896	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
648757000897	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
648757000898	active site
648757000899	catalytic tetrad [active]
648757000900	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
648757000901	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
648757000902	Helix-turn-helix domains; Region: HTH; cl00088
648757000903	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
648757000904	dimerization interface [polypeptide binding]; other site
648757000905	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
648757000906	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
648757000907	tetramer interface [polypeptide binding]; other site
648757000908	heme binding pocket [chemical binding]; other site
648757000909	NADPH binding site [chemical binding]; other site
648757000910	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
648757000911	cobaltochelatase, CobT subunit; Region: CobT; TIGR01651
648757000912	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
648757000913	metal ion-dependent adhesion site (MIDAS); other site
648757000914	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
648757000915	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
648757000916	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757000917	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
648757000918	HSP70 interaction site [polypeptide binding]; other site
648757000919	BolA-like protein; Region: BolA; cl00386
648757000920	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
648757000921	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
648757000922	Protein of unknown function (DUF1614); Region: DUF1614; cl15407
648757000923	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
648757000924	catalytic motif [active]
648757000925	Catalytic residue [active]
648757000926	Predicted aspartyl protease [General function prediction only]; Region: COG3577
648757000927	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
648757000928	catalytic motif [active]
648757000929	Catalytic residue [active]
648757000930	DNA primase; Validated; Region: dnaG; PRK05667
648757000931	CHC2 zinc finger; Region: zf-CHC2; cl15369
648757000932	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
648757000933	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
648757000934	active site
648757000935	metal binding site [ion binding]; metal-binding site
648757000936	interdomain interaction site; other site
648757000937	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
648757000938	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
648757000939	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
648757000940	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
648757000941	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
648757000942	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
648757000943	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
648757000944	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
648757000945	DNA binding residues [nucleotide binding]
648757000946	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
648757000947	putative GSH binding site [chemical binding]; other site
648757000948	catalytic residues [active]
648757000949	BolA-like protein; Region: BolA; cl00386
648757000950	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
648757000951	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
648757000952	active site
648757000953	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
648757000954	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
648757000955	Sel1 repeat; Region: Sel1; cl02723
648757000956	Sel1 repeat; Region: Sel1; cl02723
648757000957	Sel1 repeat; Region: Sel1; cl02723
648757000958	Sel1 repeat; Region: Sel1; cl02723
648757000959	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
648757000960	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
648757000961	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
648757000962	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296
648757000963	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
648757000964	putative active site [active]
648757000965	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
648757000966	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757000967	Walker A/P-loop; other site
648757000968	ATP binding site [chemical binding]; other site
648757000969	Q-loop/lid; other site
648757000970	ABC transporter signature motif; other site
648757000971	Walker B; other site
648757000972	D-loop; other site
648757000973	H-loop/switch region; other site
648757000974	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
648757000975	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
648757000976	active site
648757000977	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757000978	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
648757000979	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
648757000980	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
648757000981	S-adenosylmethionine binding site [chemical binding]; other site
648757000982	Helix-turn-helix domains; Region: HTH; cl00088
648757000983	Winged helix-turn helix; Region: HTH_29; pfam13551
648757000984	Helix-turn-helix domains; Region: HTH; cl00088
648757000985	Integrase core domain; Region: rve; cl01316
648757000986	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
648757000987	putative peptidoglycan binding site; other site
648757000988	invasion associated secreted endopeptidase; Provisional; Region: PRK13914
648757000989	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
648757000990	putative peptidoglycan binding site; other site
648757000991	Peptidase family M23; Region: Peptidase_M23; pfam01551
648757000992	malonyl-CoA synthase; Validated; Region: PRK07514
648757000993	AMP-binding enzyme; Region: AMP-binding; cl15778
648757000994	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
648757000995	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
648757000996	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
648757000997	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
648757000998	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
648757000999	Helix-turn-helix domains; Region: HTH; cl00088
648757001000	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
648757001001	trigger factor; Provisional; Region: tig; PRK01490
648757001002	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
648757001003	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
648757001004	Clp protease; Region: CLP_protease; pfam00574
648757001005	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
648757001006	oligomer interface [polypeptide binding]; other site
648757001007	active site residues [active]
648757001008	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
648757001009	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
648757001010	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
648757001011	Walker A motif; other site
648757001012	ATP binding site [chemical binding]; other site
648757001013	Walker B motif; other site
648757001014	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
648757001015	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
648757001016	Found in ATP-dependent protease La (LON); Region: LON; smart00464
648757001017	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
648757001018	Walker A motif; other site
648757001019	ATP binding site [chemical binding]; other site
648757001020	Walker B motif; other site
648757001021	arginine finger; other site
648757001022	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
648757001023	Cupin superfamily (DUF985); Region: Cupin_5; cl01418
648757001024	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
648757001025	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
648757001026	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
648757001027	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
648757001028	putative dimer interface [polypeptide binding]; other site
648757001029	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
648757001030	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
648757001031	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
648757001032	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
648757001033	SET domain; Region: SET; cl02566
648757001034	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
648757001035	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
648757001036	Sporulation related domain; Region: SPOR; cl10051
648757001037	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
648757001038	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
648757001039	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
648757001040	Walker A motif; other site
648757001041	ATP binding site [chemical binding]; other site
648757001042	Walker B motif; other site
648757001043	arginine finger; other site
648757001044	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
648757001045	Walker A motif; other site
648757001046	ATP binding site [chemical binding]; other site
648757001047	Walker B motif; other site
648757001048	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
648757001049	AzlC protein; Region: AzlC; cl00570
648757001050	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
648757001051	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
648757001052	homotrimer interaction site [polypeptide binding]; other site
648757001053	putative active site [active]
648757001054	Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839
648757001055	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003
648757001056	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
648757001057	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
648757001058	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
648757001059	catalytic residues [active]
648757001060	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
648757001061	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
648757001062	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
648757001063	protein binding site [polypeptide binding]; other site
648757001064	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
648757001065	protein binding site [polypeptide binding]; other site
648757001066	Peptidase family M48; Region: Peptidase_M48; cl12018
648757001067	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
648757001068	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
648757001069	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
648757001070	S-adenosylmethionine binding site [chemical binding]; other site
648757001071	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
648757001072	NeuB family; Region: NeuB; cl00496
648757001073	CTP synthetase; Validated; Region: pyrG; PRK05380
648757001074	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
648757001075	Catalytic site [active]
648757001076	active site
648757001077	UTP binding site [chemical binding]; other site
648757001078	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
648757001079	active site
648757001080	putative oxyanion hole; other site
648757001081	catalytic triad [active]
648757001082	Preprotein translocase SecG subunit; Region: SecG; cl09123
648757001083	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
648757001084	Isochorismatase family; Region: Isochorismatase; pfam00857
648757001085	catalytic triad [active]
648757001086	conserved cis-peptide bond; other site
648757001087	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
648757001088	substrate binding site [chemical binding]; other site
648757001089	dimer interface [polypeptide binding]; other site
648757001090	catalytic triad [active]
648757001091	SurA N-terminal domain; Region: SurA_N_3; cl07813
648757001092	periplasmic folding chaperone; Provisional; Region: PRK10788
648757001093	PPIC-type PPIASE domain; Region: Rotamase; cl08278
648757001094	anthranilate synthase component I; Provisional; Region: PRK13573
648757001095	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
648757001096	chorismate binding enzyme; Region: Chorismate_bind; cl10555
648757001097	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
648757001098	catalytic core [active]
648757001099	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
648757001100	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
648757001101	glutamine binding [chemical binding]; other site
648757001102	catalytic triad [active]
648757001103	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
648757001104	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
648757001105	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
648757001106	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
648757001107	active site
648757001108	ribulose/triose binding site [chemical binding]; other site
648757001109	phosphate binding site [ion binding]; other site
648757001110	substrate (anthranilate) binding pocket [chemical binding]; other site
648757001111	product (indole) binding pocket [chemical binding]; other site
648757001112	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
648757001113	trimer interface [polypeptide binding]; other site
648757001114	dimer interface [polypeptide binding]; other site
648757001115	putative active site [active]
648757001116	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
648757001117	ArgK protein; Region: ArgK; pfam03308
648757001118	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757001119	pyruvate phosphate dikinase; Provisional; Region: PRK09279
648757001120	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
648757001121	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
648757001122	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
648757001123	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
648757001124	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
648757001125	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
648757001126	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
648757001127	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
648757001128	substrate binding pocket [chemical binding]; other site
648757001129	membrane-bound complex binding site; other site
648757001130	hinge residues; other site
648757001131	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
648757001132	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
648757001133	Walker A/P-loop; other site
648757001134	ATP binding site [chemical binding]; other site
648757001135	Q-loop/lid; other site
648757001136	ABC transporter signature motif; other site
648757001137	Walker B; other site
648757001138	D-loop; other site
648757001139	H-loop/switch region; other site
648757001140	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
648757001141	dimer interface [polypeptide binding]; other site
648757001142	conserved gate region; other site
648757001143	putative PBP binding loops; other site
648757001144	ABC-ATPase subunit interface; other site
648757001145	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
648757001146	NMT1-like family; Region: NMT1_2; cl15260
648757001147	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
648757001148	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
648757001149	Chain length determinant protein; Region: Wzz; cl15801
648757001150	Chain length determinant protein; Region: Wzz; cl15801
648757001151	Chain length determinant protein; Region: Wzz; cl15801
648757001152	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757001153	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
648757001154	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
648757001155	SLBB domain; Region: SLBB; pfam10531
648757001156	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
648757001157	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
648757001158	Integrase core domain; Region: rve; cl01316
648757001159	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
648757001160	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
648757001161	Helix-turn-helix domains; Region: HTH; cl00088
648757001162	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
648757001163	O-Antigen ligase; Region: Wzy_C; cl04850
648757001164	Helix-turn-helix domains; Region: HTH; cl00088
648757001165	Winged helix-turn helix; Region: HTH_29; pfam13551
648757001166	Integrase core domain; Region: rve; cl01316
648757001167	DDE domain; Region: DDE_Tnp_IS240; pfam13610
648757001168	Integrase core domain; Region: rve_3; cl15866
648757001169	Helix-turn-helix domains; Region: HTH; cl00088
648757001170	Winged helix-turn helix; Region: HTH_29; pfam13551
648757001171	Helix-turn-helix domains; Region: HTH; cl00088
648757001172	Integrase core domain; Region: rve; cl01316
648757001173	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
648757001174	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
648757001175	Bacterial sugar transferase; Region: Bac_transf; cl00939
648757001176	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
648757001177	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
648757001178	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757001179	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757001180	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
648757001181	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
648757001182	putative NAD(P) binding site [chemical binding]; other site
648757001183	active site
648757001184	putative substrate binding site [chemical binding]; other site
648757001185	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757001186	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
648757001187	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
648757001188	active site
648757001189	dimer interface [polypeptide binding]; other site
648757001190	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
648757001191	Ligand Binding Site [chemical binding]; other site
648757001192	Molecular Tunnel; other site
648757001193	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
648757001194	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
648757001195	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u5; cd10929
648757001196	putative active site [active]
648757001197	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
648757001198	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
648757001199	putative ADP-binding pocket [chemical binding]; other site
648757001200	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
648757001201	Helix-turn-helix domains; Region: HTH; cl00088
648757001202	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
648757001203	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
648757001204	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
648757001205	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
648757001206	Integrase core domain; Region: rve; cl01316
648757001207	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
648757001208	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
648757001209	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
648757001210	active site
648757001211	dimer interface [polypeptide binding]; other site
648757001212	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
648757001213	Ligand Binding Site [chemical binding]; other site
648757001214	Molecular Tunnel; other site
648757001215	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
648757001216	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
648757001217	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
648757001218	putative ADP-binding pocket [chemical binding]; other site
648757001219	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
648757001220	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
648757001221	active site
648757001222	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
648757001223	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
648757001224	active site
648757001225	MatE; Region: MatE; cl10513
648757001226	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
648757001227	trimer interface [polypeptide binding]; other site
648757001228	active site
648757001229	substrate binding site [chemical binding]; other site
648757001230	CoA binding site [chemical binding]; other site
648757001231	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
648757001232	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
648757001233	inhibitor-cofactor binding pocket; inhibition site
648757001234	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757001235	catalytic residue [active]
648757001236	OpgC protein; Region: OpgC_C; cl00792
648757001237	Acyltransferase family; Region: Acyl_transf_3; pfam01757
648757001238	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
648757001239	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
648757001240	putative trimer interface [polypeptide binding]; other site
648757001241	putative CoA binding site [chemical binding]; other site
648757001242	Cupin domain; Region: Cupin_2; cl09118
648757001243	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
648757001244	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
648757001245	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
648757001246	S-adenosylmethionine binding site [chemical binding]; other site
648757001247	transcriptional activator RfaH; Region: RfaH; TIGR01955
648757001248	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
648757001249	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
648757001250	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
648757001251	putative ADP-binding pocket [chemical binding]; other site
648757001252	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
648757001253	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
648757001254	Helix-turn-helix domains; Region: HTH; cl00088
648757001255	Winged helix-turn helix; Region: HTH_29; pfam13551
648757001256	Integrase core domain; Region: rve; cl01316
648757001257	DDE domain; Region: DDE_Tnp_IS240; pfam13610
648757001258	Integrase core domain; Region: rve_3; cl15866
648757001259	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
648757001260	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
648757001261	Bacterial sugar transferase; Region: Bac_transf; cl00939
648757001262	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
648757001263	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
648757001264	dimerization interface [polypeptide binding]; other site
648757001265	ATP binding site [chemical binding]; other site
648757001266	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
648757001267	dimerization interface [polypeptide binding]; other site
648757001268	ATP binding site [chemical binding]; other site
648757001269	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
648757001270	putative active site [active]
648757001271	catalytic triad [active]
648757001272	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789
648757001273	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
648757001274	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
648757001275	ATP binding site [chemical binding]; other site
648757001276	active site
648757001277	substrate binding site [chemical binding]; other site
648757001278	Domain of unknown function (DUF1476); Region: DUF1476; cl11571
648757001279	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
648757001280	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
648757001281	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
648757001282	catalytic loop [active]
648757001283	iron binding site [ion binding]; other site
648757001284	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
648757001285	Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979
648757001286	NHLP leader peptide domain; Region: TOMM_pelo; cl15464
648757001287	nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486
648757001288	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
648757001289	active site
648757001290	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
648757001291	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
648757001292	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
648757001293	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
648757001294	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
648757001295	NAD binding site [chemical binding]; other site
648757001296	homotetramer interface [polypeptide binding]; other site
648757001297	homodimer interface [polypeptide binding]; other site
648757001298	substrate binding site [chemical binding]; other site
648757001299	active site
648757001300	Protein of unknown function (DUF3138); Region: DUF3138; pfam11336
648757001301	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
648757001302	catalytic core [active]
648757001303	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
648757001304	Tetramer interface [polypeptide binding]; other site
648757001305	active site
648757001306	FMN-binding site [chemical binding]; other site
648757001307	short chain dehydrogenase; Provisional; Region: PRK07201
648757001308	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
648757001309	putative NAD(P) binding site [chemical binding]; other site
648757001310	active site
648757001311	putative substrate binding site [chemical binding]; other site
648757001312	classical (c) SDRs; Region: SDR_c; cd05233
648757001313	NAD(P) binding site [chemical binding]; other site
648757001314	active site
648757001315	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863
648757001316	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
648757001317	nucleophile elbow; other site
648757001318	Helix-turn-helix domains; Region: HTH; cl00088
648757001319	Bacterial transcriptional repressor; Region: TetR; pfam13972
648757001320	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
648757001321	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
648757001322	TPR motif; other site
648757001323	binding surface
648757001324	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
648757001325	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
648757001326	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
648757001327	putative ADP-binding pocket [chemical binding]; other site
648757001328	manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845
648757001329	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
648757001330	manganese transport regulator MntR; Provisional; Region: PRK11050
648757001331	Helix-turn-helix domains; Region: HTH; cl00088
648757001332	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
648757001333	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
648757001334	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
648757001335	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
648757001336	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
648757001337	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
648757001338	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
648757001339	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
648757001340	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
648757001341	HI0933-like protein; Region: HI0933_like; pfam03486
648757001342	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757001343	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
648757001344	Domain of unknown function (DUF4202); Region: DUF4202; pfam13875
648757001345	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
648757001346	Ribonuclease P; Region: Ribonuclease_P; cl00457
648757001347	membrane protein insertase; Provisional; Region: PRK01318
648757001348	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
648757001349	Predicted GTPase [General function prediction only]; Region: COG0218
648757001350	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
648757001351	G1 box; other site
648757001352	GTP/Mg2+ binding site [chemical binding]; other site
648757001353	Switch I region; other site
648757001354	G2 box; other site
648757001355	G3 box; other site
648757001356	Switch II region; other site
648757001357	G4 box; other site
648757001358	G5 box; other site
648757001359	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
648757001360	Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538
648757001361	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
648757001362	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
648757001363	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
648757001364	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
648757001365	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
648757001366	DNA binding residues [nucleotide binding]
648757001367	Protein of unknown function (DUF2611); Region: DUF2611; pfam11022
648757001368	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
648757001369	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
648757001370	multidrug efflux protein; Reviewed; Region: PRK09579
648757001371	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
648757001372	intersubunit interface [polypeptide binding]; other site
648757001373	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
648757001374	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
648757001375	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757001376	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14264
648757001377	ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840
648757001378	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757001379	Walker A/P-loop; other site
648757001380	ATP binding site [chemical binding]; other site
648757001381	Q-loop/lid; other site
648757001382	ABC transporter signature motif; other site
648757001383	Walker B; other site
648757001384	D-loop; other site
648757001385	H-loop/switch region; other site
648757001386	Periplasmic binding protein TroA_e.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142
648757001387	putative ligand binding residues [chemical binding]; other site
648757001388	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
648757001389	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
648757001390	ABC-ATPase subunit  interface; other site
648757001391	dimer interface [polypeptide binding]; other site
648757001392	putative PBP binding regions; other site
648757001393	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
648757001394	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
648757001395	Walker A/P-loop; other site
648757001396	ATP binding site [chemical binding]; other site
648757001397	Q-loop/lid; other site
648757001398	ABC transporter signature motif; other site
648757001399	Walker B; other site
648757001400	D-loop; other site
648757001401	H-loop/switch region; other site
648757001402	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
648757001403	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
648757001404	N-terminal plug; other site
648757001405	ligand-binding site [chemical binding]; other site
648757001406	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
648757001407	putative FMN binding site [chemical binding]; other site
648757001408	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
648757001409	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757001410	Walker A/P-loop; other site
648757001411	ATP binding site [chemical binding]; other site
648757001412	Q-loop/lid; other site
648757001413	ABC transporter signature motif; other site
648757001414	Walker B; other site
648757001415	D-loop; other site
648757001416	H-loop/switch region; other site
648757001417	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757001418	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
648757001419	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
648757001420	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
648757001421	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
648757001422	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
648757001423	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
648757001424	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
648757001425	GAF domain; Region: GAF; cl15785
648757001426	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
648757001427	Walker A motif; other site
648757001428	ATP binding site [chemical binding]; other site
648757001429	Walker B motif; other site
648757001430	arginine finger; other site
648757001431	Helix-turn-helix domains; Region: HTH; cl00088
648757001432	Nitrogen fixation protein of unknown function; Region: Nif11; cl06756
648757001433	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
648757001434	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
648757001435	dimer interface [polypeptide binding]; other site
648757001436	active site
648757001437	metal binding site [ion binding]; metal-binding site
648757001438	glutathione binding site [chemical binding]; other site
648757001439	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
648757001440	nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284
648757001441	Nitrogenase_VFe_alpha -like: Nitrogenase VFe protein, alpha subunit like. This group contains proteins similar to the alpha subunits of,  the VFe protein of the vanadium-dependent (V-) nitrogenase and the FeFe protein of the iron only (Fe-) nitrogenase...; Region: Nitrogenase_VFe_alpha; cd01977
648757001442	Vanadium/alternative nitrogenase delta subunit; Region: AnfG_VnfG; cl03910
648757001443	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
648757001444	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
648757001445	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
648757001446	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
648757001447	dimer interface [polypeptide binding]; other site
648757001448	conserved gate region; other site
648757001449	ABC-ATPase subunit interface; other site
648757001450	NMT1-like family; Region: NMT1_2; cl15260
648757001451	phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098
648757001452	ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond.  Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256
648757001453	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
648757001454	Walker A/P-loop; other site
648757001455	ATP binding site [chemical binding]; other site
648757001456	Q-loop/lid; other site
648757001457	ABC transporter signature motif; other site
648757001458	Walker B; other site
648757001459	D-loop; other site
648757001460	H-loop/switch region; other site
648757001461	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
648757001462	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
648757001463	putative NAD(P) binding site [chemical binding]; other site
648757001464	active site
648757001465	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
648757001466	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
648757001467	C-terminal domain interface [polypeptide binding]; other site
648757001468	GSH binding site (G-site) [chemical binding]; other site
648757001469	dimer interface [polypeptide binding]; other site
648757001470	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
648757001471	N-terminal domain interface [polypeptide binding]; other site
648757001472	dimer interface [polypeptide binding]; other site
648757001473	substrate binding pocket (H-site) [chemical binding]; other site
648757001474	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
648757001475	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
648757001476	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
648757001477	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
648757001478	putative NAD(P) binding site [chemical binding]; other site
648757001479	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
648757001480	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
648757001481	This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819
648757001482	putative ADP-binding pocket [chemical binding]; other site
648757001483	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
648757001484	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
648757001485	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
648757001486	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552
648757001487	30S subunit binding site; other site
648757001488	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
648757001489	active site
648757001490	phosphorylation site [posttranslational modification]
648757001491	Predicted periplasmic protein [Function unknown]; Region: COG3698
648757001492	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
648757001493	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
648757001494	magnesium chelatase subunit I; Provisional; Region: bchI; PRK13407
648757001495	magnesium chelatase subunit D; Provisional; Region: bchD; PRK13406
648757001496	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
648757001497	metal ion-dependent adhesion site (MIDAS); other site
648757001498	putative magnesium chelatase accessory protein; Region: bchO_mg_che_rel; TIGR03056
648757001499	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
648757001500	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
648757001501	binding surface
648757001502	TPR motif; other site
648757001503	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
648757001504	binding surface
648757001505	TPR motif; other site
648757001506	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
648757001507	binding surface
648757001508	TPR repeat; Region: TPR_11; pfam13414
648757001509	TPR motif; other site
648757001510	TPR repeat; Region: TPR_11; pfam13414
648757001511	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
648757001512	binding surface
648757001513	TPR motif; other site
648757001514	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
648757001515	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
648757001516	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
648757001517	putative active site [active]
648757001518	putative metal binding site [ion binding]; other site
648757001519	fructokinase; Reviewed; Region: PRK09557
648757001520	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
648757001521	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
648757001522	putative carbohydrate kinase; Provisional; Region: PRK10565
648757001523	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
648757001524	putative substrate binding site [chemical binding]; other site
648757001525	putative ATP binding site [chemical binding]; other site
648757001526	Nitrogen regulatory protein P-II; Region: P-II; cl00412
648757001527	Nitrogen regulatory protein P-II; Region: P-II; smart00938
648757001528	glutamine synthetase; Provisional; Region: glnA; PRK09469
648757001529	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
648757001530	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
648757001531	Uncharacterized protein family (UPF0262); Region: UPF0262; cl11489
648757001532	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
648757001533	histidinol dehydrogenase; Region: hisD; TIGR00069
648757001534	NAD binding site [chemical binding]; other site
648757001535	dimerization interface [polypeptide binding]; other site
648757001536	product binding site; other site
648757001537	substrate binding site [chemical binding]; other site
648757001538	zinc binding site [ion binding]; other site
648757001539	catalytic residues [active]
648757001540	Protein of unknown function (DUF2948); Region: DUF2948; pfam11164
648757001541	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
648757001542	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
648757001543	hinge; other site
648757001544	active site
648757001545	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
648757001546	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
648757001547	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
648757001548	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757001549	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
648757001550	NAD(P) binding site [chemical binding]; other site
648757001551	active site
648757001552	SCP-2 sterol transfer family; Region: SCP2; cl01225
648757001553	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
648757001554	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
648757001555	DNA binding residues [nucleotide binding]
648757001556	putative dimer interface [polypeptide binding]; other site
648757001557	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
648757001558	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
648757001559	dimer interface [polypeptide binding]; other site
648757001560	active site
648757001561	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
648757001562	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
648757001563	substrate binding site [chemical binding]; other site
648757001564	oxyanion hole (OAH) forming residues; other site
648757001565	trimer interface [polypeptide binding]; other site
648757001566	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757001567	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
648757001568	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
648757001569	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
648757001570	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
648757001571	substrate binding pocket [chemical binding]; other site
648757001572	membrane-bound complex binding site; other site
648757001573	hinge residues; other site
648757001574	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
648757001575	serine acetyltransferase; Provisional; Region: cysE; PRK11132
648757001576	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
648757001577	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
648757001578	trimer interface [polypeptide binding]; other site
648757001579	active site
648757001580	substrate binding site [chemical binding]; other site
648757001581	CoA binding site [chemical binding]; other site
648757001582	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
648757001583	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
648757001584	PhnA protein; Region: PhnA; pfam03831
648757001585	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
648757001586	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
648757001587	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
648757001588	MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1.  In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249
648757001589	Walker A/P-loop; other site
648757001590	ATP binding site [chemical binding]; other site
648757001591	Q-loop/lid; other site
648757001592	ABC transporter signature motif; other site
648757001593	Walker B; other site
648757001594	D-loop; other site
648757001595	H-loop/switch region; other site
648757001596	FtsH Extracellular; Region: FtsH_ext; pfam06480
648757001597	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
648757001598	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
648757001599	Walker A motif; other site
648757001600	ATP binding site [chemical binding]; other site
648757001601	Walker B motif; other site
648757001602	arginine finger; other site
648757001603	Peptidase family M41; Region: Peptidase_M41; pfam01434
648757001604	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
648757001605	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
648757001606	Protein export membrane protein; Region: SecD_SecF; cl14618
648757001607	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
648757001608	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
648757001609	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
648757001610	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
648757001611	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319
648757001612	Protein of unknown function (DUF1007); Region: DUF1007; cl01487
648757001613	Protein of unknown function (DUF2796); Region: DUF2796; pfam10986
648757001614	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
648757001615	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
648757001616	Walker A/P-loop; other site
648757001617	ATP binding site [chemical binding]; other site
648757001618	Q-loop/lid; other site
648757001619	ABC transporter signature motif; other site
648757001620	Walker B; other site
648757001621	D-loop; other site
648757001622	H-loop/switch region; other site
648757001623	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
648757001624	FtsX-like permease family; Region: FtsX; cl15850
648757001625	Protein of unknown function (DUF3299); Region: DUF3299; cl01387
648757001626	NnrS protein; Region: NnrS; cl01258
648757001627	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
648757001628	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
648757001629	ligand binding site [chemical binding]; other site
648757001630	flexible hinge region; other site
648757001631	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
648757001632	putative switch regulator; other site
648757001633	non-specific DNA interactions [nucleotide binding]; other site
648757001634	DNA binding site [nucleotide binding]
648757001635	sequence specific DNA binding site [nucleotide binding]; other site
648757001636	putative cAMP binding site [chemical binding]; other site
648757001637	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
648757001638	dimerization interface [polypeptide binding]; other site
648757001639	putative DNA binding site [nucleotide binding]; other site
648757001640	putative Zn2+ binding site [ion binding]; other site
648757001641	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
648757001642	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
648757001643	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cd00562
648757001644	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
648757001645	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
648757001646	ligand binding site [chemical binding]; other site
648757001647	flexible hinge region; other site
648757001648	Helix-turn-helix domains; Region: HTH; cl00088
648757001649	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
648757001650	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757001651	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
648757001652	catalytic triad [active]
648757001653	Polysulphide reductase, NrfD; Region: NrfD; cl01295
648757001654	Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301
648757001655	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
648757001656	4Fe-4S binding domain; Region: Fer4; cl02805
648757001657	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
648757001658	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757001659	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
648757001660	4Fe-4S binding domain; Region: Fer4; cl02805
648757001661	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
648757001662	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
648757001663	DsrC like protein; Region: DsrC; cl01101
648757001664	DsrE/DsrF-like family; Region: DrsE; cl00672
648757001665	DsrE/DsrF-like family; Region: DrsE; cl00672
648757001666	DsrE/DsrF-like family; Region: DrsE; cl00672
648757001667	sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066
648757001668	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
648757001669	sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064
648757001670	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
648757001671	siroheme synthase; Provisional; Region: cysG; PRK10637
648757001672	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757001673	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
648757001674	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
648757001675	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
648757001676	DsrE/DsrF-like family; Region: DrsE; cl00672
648757001677	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
648757001678	CPxP  motif; other site
648757001679	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
648757001680	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
648757001681	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
648757001682	catalytic residue [active]
648757001683	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
648757001684	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757001685	ATP binding site [chemical binding]; other site
648757001686	Mg2+ binding site [ion binding]; other site
648757001687	G-X-G motif; other site
648757001688	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
648757001689	intermolecular recognition site; other site
648757001690	active site
648757001691	dimerization interface [polypeptide binding]; other site
648757001692	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
648757001693	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
648757001694	N-terminal plug; other site
648757001695	ligand-binding site [chemical binding]; other site
648757001696	ribonuclease PH; Reviewed; Region: rph; PRK00173
648757001697	Ribonuclease PH; Region: RNase_PH_bact; cd11362
648757001698	hexamer interface [polypeptide binding]; other site
648757001699	active site
648757001700	pyruvate kinase; Provisional; Region: PRK06247
648757001701	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
648757001702	domain interfaces; other site
648757001703	active site
648757001704	Protein of unknown function (DUF1036); Region: DUF1036; cl02296
648757001705	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
648757001706	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
648757001707	MOFRL family; Region: MOFRL; pfam05161
648757001708	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106
648757001709	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
648757001710	dimerization interface [polypeptide binding]; other site
648757001711	active site
648757001712	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
648757001713	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757001714	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
648757001715	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
648757001716	Sel1 repeat; Region: Sel1; cl02723
648757001717	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
648757001718	Sel1 repeat; Region: Sel1; cl02723
648757001719	Sel1 repeat; Region: Sel1; cl02723
648757001720	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
648757001721	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
648757001722	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
648757001723	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
648757001724	Staphylococcal nuclease homologues; Region: SNc; smart00318
648757001725	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
648757001726	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
648757001727	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
648757001728	N-terminal domain interface [polypeptide binding]; other site
648757001729	dimer interface [polypeptide binding]; other site
648757001730	substrate binding pocket (H-site) [chemical binding]; other site
648757001731	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757001732	acetoacetyl-CoA reductase; Provisional; Region: PRK12824
648757001733	NAD(P) binding site [chemical binding]; other site
648757001734	active site
648757001735	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
648757001736	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
648757001737	putative DNA binding site [nucleotide binding]; other site
648757001738	putative homodimer interface [polypeptide binding]; other site
648757001739	DNA polymerase Ligase (LigD); Region: LigD_N; cl11819
648757001740	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
648757001741	active site
648757001742	DNA binding site [nucleotide binding]
648757001743	DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776
648757001744	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
648757001745	DNA binding site [nucleotide binding]
648757001746	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
648757001747	nucleotide binding site [chemical binding]; other site
648757001748	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
648757001749	Sel1 repeat; Region: Sel1; cl02723
648757001750	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
648757001751	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
648757001752	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
648757001753	Walker A motif; other site
648757001754	ATP binding site [chemical binding]; other site
648757001755	Walker B motif; other site
648757001756	arginine finger; other site
648757001757	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
648757001758	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
648757001759	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
648757001760	Peptidase propeptide and YPEB domain; Region: PepSY; cl15815
648757001761	Peptidase propeptide and YPEB domain; Region: PepSY; cl15815
648757001762	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
648757001763	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757001764	active site
648757001765	phosphorylation site [posttranslational modification]
648757001766	intermolecular recognition site; other site
648757001767	dimerization interface [polypeptide binding]; other site
648757001768	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
648757001769	DNA binding site [nucleotide binding]
648757001770	sensor protein PhoQ; Provisional; Region: PRK10815
648757001771	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757001772	ATP binding site [chemical binding]; other site
648757001773	Mg2+ binding site [ion binding]; other site
648757001774	G-X-G motif; other site
648757001775	Trm112p-like protein; Region: Trm112p; cl01066
648757001776	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
648757001777	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
648757001778	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
648757001779	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
648757001780	putative acyl transferase; Provisional; Region: PRK10502
648757001781	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
648757001782	putative trimer interface [polypeptide binding]; other site
648757001783	putative active site [active]
648757001784	putative substrate binding site [chemical binding]; other site
648757001785	putative CoA binding site [chemical binding]; other site
648757001786	malate dehydrogenase; Reviewed; Region: PRK06223
648757001787	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
648757001788	NAD(P) binding site [chemical binding]; other site
648757001789	dimer interface [polypeptide binding]; other site
648757001790	tetramer (dimer of dimers) interface [polypeptide binding]; other site
648757001791	substrate binding site [chemical binding]; other site
648757001792	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
648757001793	ATP-grasp domain; Region: ATP-grasp_4; cl03087
648757001794	CoA-ligase; Region: Ligase_CoA; cl02894
648757001795	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
648757001796	putative active site [active]
648757001797	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
648757001798	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757001799	CoA-ligase; Region: Ligase_CoA; cl02894
648757001800	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
648757001801	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
648757001802	TPP-binding site [chemical binding]; other site
648757001803	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
648757001804	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
648757001805	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
648757001806	E3 interaction surface; other site
648757001807	lipoyl attachment site [posttranslational modification]; other site
648757001808	e3 binding domain; Region: E3_binding; pfam02817
648757001809	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
648757001810	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06115
648757001811	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757001812	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
648757001813	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
648757001814	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
648757001815	dimerization domain swap beta strand [polypeptide binding]; other site
648757001816	regulatory protein interface [polypeptide binding]; other site
648757001817	active site
648757001818	regulatory phosphorylation site [posttranslational modification]; other site
648757001819	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
648757001820	active pocket/dimerization site; other site
648757001821	active site
648757001822	phosphorylation site [posttranslational modification]
648757001823	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
648757001824	Hpr binding site; other site
648757001825	active site
648757001826	homohexamer subunit interaction site [polypeptide binding]; other site
648757001827	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
648757001828	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
648757001829	dimer interface [polypeptide binding]; other site
648757001830	phosphorylation site [posttranslational modification]
648757001831	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757001832	ATP binding site [chemical binding]; other site
648757001833	Mg2+ binding site [ion binding]; other site
648757001834	G-X-G motif; other site
648757001835	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
648757001836	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757001837	active site
648757001838	phosphorylation site [posttranslational modification]
648757001839	intermolecular recognition site; other site
648757001840	dimerization interface [polypeptide binding]; other site
648757001841	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
648757001842	DNA binding site [nucleotide binding]
648757001843	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
648757001844	active site
648757001845	substrate-binding site [chemical binding]; other site
648757001846	metal-binding site [ion binding]
648757001847	ATP binding site [chemical binding]; other site
648757001848	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
648757001849	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
648757001850	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
648757001851	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
648757001852	Walker A motif; other site
648757001853	ATP binding site [chemical binding]; other site
648757001854	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
648757001855	B1 nucleotide binding pocket [chemical binding]; other site
648757001856	B2 nucleotide binding pocket [chemical binding]; other site
648757001857	CAS motifs; other site
648757001858	active site
648757001859	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
648757001860	PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570
648757001861	dimerization interface 3.5A [polypeptide binding]; other site
648757001862	active site
648757001863	transposase; Validated; Region: PRK08181
648757001864	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
648757001865	Walker A motif; other site
648757001866	ATP binding site [chemical binding]; other site
648757001867	Phasin protein; Region: Phasin_2; cl11491
648757001868	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
648757001869	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
648757001870	amidase catalytic site [active]
648757001871	Zn binding residues [ion binding]; other site
648757001872	substrate binding site [chemical binding]; other site
648757001873	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
648757001874	ligand binding site [chemical binding]; other site
648757001875	flexible hinge region; other site
648757001876	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
648757001877	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine...; Region: adenosine_kinase; cd01168
648757001878	substrate binding site [chemical binding]; other site
648757001879	ATP binding site [chemical binding]; other site
648757001880	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
648757001881	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
648757001882	minor groove reading motif; other site
648757001883	helix-hairpin-helix signature motif; other site
648757001884	substrate binding pocket [chemical binding]; other site
648757001885	active site
648757001886	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
648757001887	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
648757001888	catalytic core [active]
648757001889	dihydrodipicolinate reductase; Provisional; Region: PRK00048
648757001890	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757001891	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
648757001892	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
648757001893	dimer interface [polypeptide binding]; other site
648757001894	substrate binding site [chemical binding]; other site
648757001895	metal binding sites [ion binding]; metal-binding site
648757001896	Transcriptional regulator; Region: Transcrip_reg; cl00361
648757001897	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
648757001898	putative homotetramer interface [polypeptide binding]; other site
648757001899	putative homodimer interface [polypeptide binding]; other site
648757001900	putative allosteric switch controlling residues; other site
648757001901	putative metal binding site [ion binding]; other site
648757001902	putative homodimer-homodimer interface [polypeptide binding]; other site
648757001903	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
648757001904	PhoU domain; Region: PhoU; pfam01895
648757001905	PhoU domain; Region: PhoU; pfam01895
648757001906	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
648757001907	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
648757001908	substrate binding site [chemical binding]; other site
648757001909	catalytic Zn binding site [ion binding]; other site
648757001910	NAD binding site [chemical binding]; other site
648757001911	structural Zn binding site [ion binding]; other site
648757001912	dimer interface [polypeptide binding]; other site
648757001913	Protein of unknown function (DUF2380); Region: DUF3280; pfam11684
648757001914	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
648757001915	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
648757001916	FeS/SAM binding site; other site
648757001917	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
648757001918	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
648757001919	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243
648757001920	ATP12 chaperone protein; Region: ATP12; cl02228
648757001921	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
648757001922	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248
648757001923	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
648757001924	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
648757001925	Protein export membrane protein; Region: SecD_SecF; cl14618
648757001926	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
648757001927	Protein export membrane protein; Region: SecD_SecF; cl14618
648757001928	Preprotein translocase subunit; Region: YajC; cl00806
648757001929	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
648757001930	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757001931	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757001932	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
648757001933	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757001934	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757001935	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
648757001936	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
648757001937	putative DNA binding site [nucleotide binding]; other site
648757001938	putative Zn2+ binding site [ion binding]; other site
648757001939	Helix-turn-helix domains; Region: HTH; cl00088
648757001940	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
648757001941	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
648757001942	dimer interface [polypeptide binding]; other site
648757001943	PYR/PP interface [polypeptide binding]; other site
648757001944	TPP binding site [chemical binding]; other site
648757001945	substrate binding site [chemical binding]; other site
648757001946	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
648757001947	TPP-binding site; other site
648757001948	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
648757001949	isovaleryl-CoA dehydrogenase; Region: PLN02519
648757001950	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
648757001951	substrate binding site [chemical binding]; other site
648757001952	FAD binding site [chemical binding]; other site
648757001953	catalytic base [active]
648757001954	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
648757001955	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
648757001956	putative active site [active]
648757001957	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
648757001958	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
648757001959	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
648757001960	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
648757001961	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
648757001962	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
648757001963	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
648757001964	carboxyltransferase (CT) interaction site; other site
648757001965	biotinylation site [posttranslational modification]; other site
648757001966	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
648757001967	active site
648757001968	catalytic residues [active]
648757001969	metal binding site [ion binding]; metal-binding site
648757001970	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
648757001971	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
648757001972	FAD binding site [chemical binding]; other site
648757001973	substrate binding pocket [chemical binding]; other site
648757001974	catalytic base [active]
648757001975	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
648757001976	CoA-transferase family III; Region: CoA_transf_3; pfam02515
648757001977	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
648757001978	Protein of unknown function (DUF2853); Region: DUF2853; pfam11015
648757001979	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
648757001980	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
648757001981	classical (c) SDRs; Region: SDR_c; cd05233
648757001982	NAD(P) binding site [chemical binding]; other site
648757001983	active site
648757001984	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
648757001985	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
648757001986	FMN binding site [chemical binding]; other site
648757001987	active site
648757001988	catalytic residues [active]
648757001989	substrate binding site [chemical binding]; other site
648757001990	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
648757001991	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
648757001992	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
648757001993	ABC transporter; Region: ABC_tran_2; pfam12848
648757001994	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
648757001995	Helix-turn-helix domains; Region: HTH; cl00088
648757001996	Winged helix-turn helix; Region: HTH_29; pfam13551
648757001997	Helix-turn-helix domains; Region: HTH; cl00088
648757001998	Integrase core domain; Region: rve; cl01316
648757001999	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757002000	AAA domain; Region: AAA_21; pfam13304
648757002001	Walker A/P-loop; other site
648757002002	ATP binding site [chemical binding]; other site
648757002003	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757002004	Walker B; other site
648757002005	D-loop; other site
648757002006	H-loop/switch region; other site
648757002007	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
648757002008	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
648757002009	putative active site [active]
648757002010	putative metal binding site [ion binding]; other site
648757002011	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
648757002012	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
648757002013	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
648757002014	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757002015	active site
648757002016	phosphorylation site [posttranslational modification]
648757002017	intermolecular recognition site; other site
648757002018	dimerization interface [polypeptide binding]; other site
648757002019	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
648757002020	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
648757002021	K+ potassium transporter; Region: K_trans; cl15781
648757002022	potassium uptake protein; Region: kup; TIGR00794
648757002023	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
648757002024	Heme NO binding; Region: HNOB; cl15268
648757002025	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
648757002026	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
648757002027	FeS/SAM binding site; other site
648757002028	HemN C-terminal domain; Region: HemN_C; pfam06969
648757002029	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
648757002030	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
648757002031	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
648757002032	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
648757002033	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
648757002034	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
648757002035	thiamine monophosphate kinase; Provisional; Region: PRK05731
648757002036	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
648757002037	ATP binding site [chemical binding]; other site
648757002038	dimerization interface [polypeptide binding]; other site
648757002039	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
648757002040	putative RNA binding site [nucleotide binding]; other site
648757002041	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
648757002042	homopentamer interface [polypeptide binding]; other site
648757002043	active site
648757002044	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
648757002045	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
648757002046	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522
648757002047	dimerization interface [polypeptide binding]; other site
648757002048	active site
648757002049	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
648757002050	Lumazine binding domain; Region: Lum_binding; pfam00677
648757002051	Lumazine binding domain; Region: Lum_binding; pfam00677
648757002052	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
648757002053	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
648757002054	catalytic motif [active]
648757002055	Zn binding site [ion binding]; other site
648757002056	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
648757002057	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
648757002058	ATP cone domain; Region: ATP-cone; pfam03477
648757002059	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
648757002060	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
648757002061	dimer interface [polypeptide binding]; other site
648757002062	glycine-pyridoxal phosphate binding site [chemical binding]; other site
648757002063	active site
648757002064	folate binding site [chemical binding]; other site
648757002065	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
648757002066	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
648757002067	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
648757002068	active site
648757002069	substrate binding site [chemical binding]; other site
648757002070	Mg2+ binding site [ion binding]; other site
648757002071	Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022
648757002072	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
648757002073	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
648757002074	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
648757002075	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
648757002076	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
648757002077	Ferritin-like domain; Region: Ferritin; pfam00210
648757002078	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
648757002079	dimerization interface [polypeptide binding]; other site
648757002080	DPS ferroxidase diiron center [ion binding]; other site
648757002081	ion pore; other site
648757002082	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
648757002083	MPT binding site; other site
648757002084	trimer interface [polypeptide binding]; other site
648757002085	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
648757002086	MoaE homodimer interface [polypeptide binding]; other site
648757002087	MoaD interaction [polypeptide binding]; other site
648757002088	active site residues [active]
648757002089	Protein of unknown function (DUF563); Region: DUF563; cl15705
648757002090	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
648757002091	endonuclease III; Region: ENDO3c; smart00478
648757002092	minor groove reading motif; other site
648757002093	helix-hairpin-helix signature motif; other site
648757002094	substrate binding pocket [chemical binding]; other site
648757002095	active site
648757002096	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
648757002097	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
648757002098	ligand binding site [chemical binding]; other site
648757002099	flexible hinge region; other site
648757002100	Helix-turn-helix domains; Region: HTH; cl00088
648757002101	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
648757002102	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
648757002103	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
648757002104	[2Fe-2S] cluster binding site [ion binding]; other site
648757002105	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
648757002106	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015
648757002107	homotrimer interaction site [polypeptide binding]; other site
648757002108	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.   The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_5; cd06153
648757002109	homotrimer interaction site [polypeptide binding]; other site
648757002110	putative active site [active]
648757002111	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
648757002112	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
648757002113	dinuclear metal binding motif [ion binding]; other site
648757002114	YceI-like domain; Region: YceI; cl01001
648757002115	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
648757002116	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
648757002117	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
648757002118	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
648757002119	NAD-dependent deacetylase; Provisional; Region: PRK00481
648757002120	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
648757002121	NAD+ binding site [chemical binding]; other site
648757002122	substrate binding site [chemical binding]; other site
648757002123	Zn binding site [ion binding]; other site
648757002124	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
648757002125	S-adenosylmethionine binding site [chemical binding]; other site
648757002126	short chain dehydrogenase; Provisional; Region: PRK06197
648757002127	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
648757002128	putative NAD(P) binding site [chemical binding]; other site
648757002129	active site
648757002130	helicase 45; Provisional; Region: PTZ00424
648757002131	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
648757002132	ATP binding site [chemical binding]; other site
648757002133	Mg++ binding site [ion binding]; other site
648757002134	motif III; other site
648757002135	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
648757002136	nucleotide binding region [chemical binding]; other site
648757002137	ATP-binding site [chemical binding]; other site
648757002138	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
648757002139	YdjC-like protein; Region: YdjC; cl01344
648757002140	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
648757002141	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
648757002142	Ligand binding site; other site
648757002143	Putative Catalytic site; other site
648757002144	DXD motif; other site
648757002145	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
648757002146	YceI-like domain; Region: YceI; cl01001
648757002147	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
648757002148	dimer interface [polypeptide binding]; other site
648757002149	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
648757002150	active site
648757002151	metal binding site [ion binding]; metal-binding site
648757002152	glutathione binding site [chemical binding]; other site
648757002153	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
648757002154	DNA-binding site [nucleotide binding]; DNA binding site
648757002155	RNA-binding motif; other site
648757002156	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
648757002157	DNA-binding site [nucleotide binding]; DNA binding site
648757002158	RNA-binding motif; other site
648757002159	Uncharacterized ACR, COG1430; Region: DUF192; cl00627
648757002160	agmatine deiminase; Region: agmatine_aguA; TIGR03380
648757002161	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113
648757002162	N-carbamolyputrescine amidase; Region: PLN02747
648757002163	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
648757002164	putative active site; other site
648757002165	catalytic triad [active]
648757002166	putative dimer interface [polypeptide binding]; other site
648757002167	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
648757002168	FAD binding domain; Region: FAD_binding_4; pfam01565
648757002169	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
648757002170	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
648757002171	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
648757002172	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
648757002173	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
648757002174	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
648757002175	NodB motif; other site
648757002176	active site
648757002177	catalytic site [active]
648757002178	metal binding site [ion binding]; metal-binding site
648757002179	EF-hand domain pair; Region: EF_hand_5; pfam13499
648757002180	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl08302
648757002181	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
648757002182	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
648757002183	DNA-binding site [nucleotide binding]; DNA binding site
648757002184	FCD domain; Region: FCD; cl11656
648757002185	Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292
648757002186	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988
648757002187	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
648757002188	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
648757002189	Substrate binding site; other site
648757002190	Mg++ binding site; other site
648757002191	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
648757002192	active site
648757002193	substrate binding site [chemical binding]; other site
648757002194	CoA binding site [chemical binding]; other site
648757002195	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
648757002196	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757002197	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
648757002198	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
648757002199	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
648757002200	glutaminase active site [active]
648757002201	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
648757002202	dimer interface [polypeptide binding]; other site
648757002203	active site
648757002204	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
648757002205	dimer interface [polypeptide binding]; other site
648757002206	active site
648757002207	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
648757002208	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
648757002209	Transcriptional regulator [Transcription]; Region: LysR; COG0583
648757002210	Helix-turn-helix domains; Region: HTH; cl00088
648757002211	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
648757002212	dimerization interface [polypeptide binding]; other site
648757002213	EamA-like transporter family; Region: EamA; cl01037
648757002214	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
648757002215	EamA-like transporter family; Region: EamA; cl01037
648757002216	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
648757002217	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
648757002218	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757002219	active site
648757002220	phosphorylation site [posttranslational modification]
648757002221	intermolecular recognition site; other site
648757002222	dimerization interface [polypeptide binding]; other site
648757002223	CheB methylesterase; Region: CheB_methylest; pfam01339
648757002224	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
648757002225	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
648757002226	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757002227	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
648757002228	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
648757002229	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
648757002230	dimer interface [polypeptide binding]; other site
648757002231	putative CheW interface [polypeptide binding]; other site
648757002232	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
648757002233	putative CheA interaction surface; other site
648757002234	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
648757002235	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
648757002236	putative binding surface; other site
648757002237	active site
648757002238	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
648757002239	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757002240	ATP binding site [chemical binding]; other site
648757002241	Mg2+ binding site [ion binding]; other site
648757002242	G-X-G motif; other site
648757002243	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
648757002244	Response regulator receiver domain; Region: Response_reg; pfam00072
648757002245	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757002246	active site
648757002247	phosphorylation site [posttranslational modification]
648757002248	intermolecular recognition site; other site
648757002249	dimerization interface [polypeptide binding]; other site
648757002250	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
648757002251	Helix-turn-helix domains; Region: HTH; cl00088
648757002252	Winged helix-turn helix; Region: HTH_29; pfam13551
648757002253	Integrase core domain; Region: rve; cl01316
648757002254	DDE domain; Region: DDE_Tnp_IS240; pfam13610
648757002255	Integrase core domain; Region: rve_3; cl15866
648757002256	Sporulation related domain; Region: SPOR; cl10051
648757002257	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
648757002258	DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603
648757002259	active site pocket [active]
648757002260	cleavage site
648757002261	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
648757002262	adenylosuccinate lyase; Provisional; Region: PRK07492
648757002263	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
648757002264	tetramer interface [polypeptide binding]; other site
648757002265	active site
648757002266	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
648757002267	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
648757002268	active site
648757002269	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
648757002270	ribosomal protein L20; Region: rpl20; CHL00068
648757002271	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
648757002272	23S rRNA binding site [nucleotide binding]; other site
648757002273	L21 binding site [polypeptide binding]; other site
648757002274	L13 binding site [polypeptide binding]; other site
648757002275	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
648757002276	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
648757002277	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
648757002278	dimer interface [polypeptide binding]; other site
648757002279	motif 1; other site
648757002280	active site
648757002281	motif 2; other site
648757002282	motif 3; other site
648757002283	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
648757002284	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
648757002285	ssDNA binding site; other site
648757002286	generic binding surface II; other site
648757002287	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
648757002288	ATP binding site [chemical binding]; other site
648757002289	putative Mg++ binding site [ion binding]; other site
648757002290	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
648757002291	nucleotide binding region [chemical binding]; other site
648757002292	ATP-binding site [chemical binding]; other site
648757002293	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
648757002294	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
648757002295	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
648757002296	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
648757002297	ATP binding site [chemical binding]; other site
648757002298	putative Mg++ binding site [ion binding]; other site
648757002299	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
648757002300	nucleotide binding region [chemical binding]; other site
648757002301	ATP-binding site [chemical binding]; other site
648757002302	TRCF domain; Region: TRCF; cl04088
648757002303	OpgC protein; Region: OpgC_C; cl00792
648757002304	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
648757002305	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
648757002306	dimerization interface [polypeptide binding]; other site
648757002307	ligand binding site [chemical binding]; other site
648757002308	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
648757002309	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
648757002310	Walker A/P-loop; other site
648757002311	ATP binding site [chemical binding]; other site
648757002312	Q-loop/lid; other site
648757002313	ABC transporter signature motif; other site
648757002314	Walker B; other site
648757002315	D-loop; other site
648757002316	H-loop/switch region; other site
648757002317	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
648757002318	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
648757002319	Walker A/P-loop; other site
648757002320	ATP binding site [chemical binding]; other site
648757002321	Q-loop/lid; other site
648757002322	ABC transporter signature motif; other site
648757002323	Walker B; other site
648757002324	D-loop; other site
648757002325	H-loop/switch region; other site
648757002326	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
648757002327	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
648757002328	TM-ABC transporter signature motif; other site
648757002329	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
648757002330	TM-ABC transporter signature motif; other site
648757002331	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
648757002332	dimerization interface [polypeptide binding]; other site
648757002333	putative DNA binding site [nucleotide binding]; other site
648757002334	putative Zn2+ binding site [ion binding]; other site
648757002335	glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209
648757002336	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
648757002337	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
648757002338	catalytic residue [active]
648757002339	Chain length determinant protein; Region: Wzz; cl15801
648757002340	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
648757002341	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
648757002342	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
648757002343	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
648757002344	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
648757002345	extended (e) SDRs; Region: SDR_e; cd08946
648757002346	NAD(P) binding site [chemical binding]; other site
648757002347	active site
648757002348	substrate binding site [chemical binding]; other site
648757002349	M28 Zn-Peptidases; Region: M28_like_3; cd05644
648757002350	Domain of unknown function (DUF2172); Region: DUF2172; pfam09940
648757002351	active site
648757002352	metal binding site [ion binding]; metal-binding site
648757002353	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
648757002354	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
648757002355	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757002356	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
648757002357	SLBB domain; Region: SLBB; pfam10531
648757002358	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
648757002359	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
648757002360	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757002361	Bacterial sugar transferase; Region: Bac_transf; cl00939
648757002362	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
648757002363	active site
648757002364	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
648757002365	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
648757002366	substrate binding site; other site
648757002367	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
648757002368	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757002369	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
648757002370	Cupin domain; Region: Cupin_2; cl09118
648757002371	Possibl zinc metallo-peptidase; Region: DUF1025; cl01577
648757002372	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
648757002373	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
648757002374	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
648757002375	active site
648757002376	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
648757002377	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
648757002378	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
648757002379	substrate binding site [chemical binding]; other site
648757002380	oxyanion hole (OAH) forming residues; other site
648757002381	trimer interface [polypeptide binding]; other site
648757002382	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757002383	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
648757002384	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
648757002385	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
648757002386	dimer interface [polypeptide binding]; other site
648757002387	active site
648757002388	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
648757002389	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
648757002390	active site
648757002391	HIGH motif; other site
648757002392	nucleotide binding site [chemical binding]; other site
648757002393	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
648757002394	active site
648757002395	KMSKS motif; other site
648757002396	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
648757002397	tRNA binding surface [nucleotide binding]; other site
648757002398	anticodon binding site; other site
648757002399	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
648757002400	active site
648757002401	multimer interface [polypeptide binding]; other site
648757002402	ribonuclease D; Region: rnd; TIGR01388
648757002403	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
648757002404	putative active site [active]
648757002405	catalytic site [active]
648757002406	putative substrate binding site [chemical binding]; other site
648757002407	HRDC domain; Region: HRDC; cl02578
648757002408	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
648757002409	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
648757002410	dimer interface [polypeptide binding]; other site
648757002411	anticodon binding site; other site
648757002412	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
648757002413	homodimer interface [polypeptide binding]; other site
648757002414	motif 1; other site
648757002415	active site
648757002416	motif 2; other site
648757002417	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
648757002418	active site
648757002419	motif 3; other site
648757002420	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
648757002421	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757002422	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
648757002423	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
648757002424	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
648757002425	thiamine phosphate binding site [chemical binding]; other site
648757002426	active site
648757002427	pyrophosphate binding site [ion binding]; other site
648757002428	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
648757002429	ThiS interaction site; other site
648757002430	putative active site [active]
648757002431	tetramer interface [polypeptide binding]; other site
648757002432	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
648757002433	thiS-thiF/thiG interaction site; other site
648757002434	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
648757002435	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
648757002436	dimer interface [polypeptide binding]; other site
648757002437	allosteric magnesium binding site [ion binding]; other site
648757002438	active site
648757002439	aspartate-rich active site metal binding site; other site
648757002440	Schiff base residues; other site
648757002441	threonine dehydratase; Provisional; Region: PRK07334
648757002442	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
648757002443	tetramer interface [polypeptide binding]; other site
648757002444	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757002445	catalytic residue [active]
648757002446	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
648757002447	Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839
648757002448	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; cl01930
648757002449	Integral membrane protein TerC family; Region: TerC; cl10468
648757002450	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
648757002451	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
648757002452	dimer interface [polypeptide binding]; other site
648757002453	active site
648757002454	Phosphopantetheine attachment site; Region: PP-binding; cl09936
648757002455	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605
648757002456	AMP-binding enzyme; Region: AMP-binding; cl15778
648757002457	AMP-binding enzyme; Region: AMP-binding; cl15778
648757002458	Protein of unknown function (DUF421); Region: DUF421; cl00990
648757002459	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
648757002460	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
648757002461	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
648757002462	multifunctional aminopeptidase A; Provisional; Region: PRK00913
648757002463	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
648757002464	interface (dimer of trimers) [polypeptide binding]; other site
648757002465	Substrate-binding/catalytic site; other site
648757002466	Zn-binding sites [ion binding]; other site
648757002467	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
648757002468	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
648757002469	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
648757002470	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
648757002471	OstA-like protein; Region: OstA; cl00844
648757002472	Organic solvent tolerance protein; Region: OstA_C; pfam04453
648757002473	SurA N-terminal domain; Region: SurA_N_3; cl07813
648757002474	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
648757002475	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
648757002476	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757002477	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
648757002478	active site residue [active]
648757002479	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
648757002480	dimerization interface [polypeptide binding]; other site
648757002481	putative DNA binding site [nucleotide binding]; other site
648757002482	putative Zn2+ binding site [ion binding]; other site
648757002483	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
648757002484	L-lactate permease; Region: Lactate_perm; cl00701
648757002485	glycolate transporter; Provisional; Region: PRK09695
648757002486	DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421
648757002487	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
648757002488	DNA-binding site [nucleotide binding]; DNA binding site
648757002489	FCD domain; Region: FCD; cl11656
648757002490	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
648757002491	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
648757002492	phosphate binding site [ion binding]; other site
648757002493	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757002494	HI0933-like protein; Region: HI0933_like; pfam03486
648757002495	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757002496	Phasin protein; Region: Phasin_2; cl11491
648757002497	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
648757002498	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
648757002499	Walker A/P-loop; other site
648757002500	ATP binding site [chemical binding]; other site
648757002501	Q-loop/lid; other site
648757002502	ABC transporter signature motif; other site
648757002503	Walker B; other site
648757002504	D-loop; other site
648757002505	H-loop/switch region; other site
648757002506	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
648757002507	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
648757002508	Walker A/P-loop; other site
648757002509	ATP binding site [chemical binding]; other site
648757002510	Q-loop/lid; other site
648757002511	ABC transporter signature motif; other site
648757002512	Walker B; other site
648757002513	D-loop; other site
648757002514	H-loop/switch region; other site
648757002515	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
648757002516	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
648757002517	putative ligand binding site [chemical binding]; other site
648757002518	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
648757002519	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
648757002520	TM-ABC transporter signature motif; other site
648757002521	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
648757002522	TM-ABC transporter signature motif; other site
648757002523	Domain of unknown function DUF21; Region: DUF21; pfam01595
648757002524	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
648757002525	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
648757002526	Transporter associated domain; Region: CorC_HlyC; cl08393
648757002527	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
648757002528	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757002529	Transglycosylase SLT domain; Region: SLT_2; pfam13406
648757002530	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
648757002531	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
648757002532	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
648757002533	C-terminal peptidase (prc); Region: prc; TIGR00225
648757002534	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
648757002535	protein binding site [polypeptide binding]; other site
648757002536	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
648757002537	Catalytic dyad [active]
648757002538	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
648757002539	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
648757002540	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
648757002541	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
648757002542	substrate binding site [chemical binding]; other site
648757002543	active site
648757002544	catalytic residues [active]
648757002545	heterodimer interface [polypeptide binding]; other site
648757002546	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
648757002547	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
648757002548	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757002549	catalytic residue [active]
648757002550	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405
648757002551	active site
648757002552	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
648757002553	IHF - DNA interface [nucleotide binding]; other site
648757002554	IHF dimer interface [polypeptide binding]; other site
648757002555	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
648757002556	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
648757002557	tandem repeat interface [polypeptide binding]; other site
648757002558	oligomer interface [polypeptide binding]; other site
648757002559	active site residues [active]
648757002560	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
648757002561	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
648757002562	RNA binding site [nucleotide binding]; other site
648757002563	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
648757002564	RNA binding site [nucleotide binding]; other site
648757002565	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688
648757002566	RNA binding site [nucleotide binding]; other site
648757002567	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
648757002568	RNA binding site [nucleotide binding]; other site
648757002569	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690
648757002570	RNA binding site [nucleotide binding]; other site
648757002571	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691
648757002572	RNA binding site [nucleotide binding]; other site
648757002573	cytidylate kinase; Provisional; Region: cmk; PRK00023
648757002574	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
648757002575	CMP-binding site; other site
648757002576	The sites determining sugar specificity; other site
648757002577	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
648757002578	3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356
648757002579	hinge; other site
648757002580	active site
648757002581	TIGR02300 family protein; Region: FYDLN_acid
648757002582	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
648757002583	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
648757002584	putative NAD(P) binding site [chemical binding]; other site
648757002585	Protein of unknown function (DUF1150); Region: DUF1150; cl11577
648757002586	SlyX; Region: SlyX; cl01090
648757002587	NMT1-like family; Region: NMT1_2; cl15260
648757002588	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
648757002589	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
648757002590	active site
648757002591	metal binding site [ion binding]; metal-binding site
648757002592	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
648757002593	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003
648757002594	Protein of unknown function (DUF1134); Region: DUF1134; cl02235
648757002595	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638
648757002596	active site
648757002597	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385
648757002598	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
648757002599	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
648757002600	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757002601	active site
648757002602	phosphorylation site [posttranslational modification]
648757002603	intermolecular recognition site; other site
648757002604	dimerization interface [polypeptide binding]; other site
648757002605	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
648757002606	DNA binding site [nucleotide binding]
648757002607	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
648757002608	polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849
648757002609	PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907
648757002610	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
648757002611	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
648757002612	putative C-terminal domain interface [polypeptide binding]; other site
648757002613	putative GSH binding site (G-site) [chemical binding]; other site
648757002614	putative dimer interface [polypeptide binding]; other site
648757002615	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
648757002616	putative N-terminal domain interface [polypeptide binding]; other site
648757002617	putative dimer interface [polypeptide binding]; other site
648757002618	putative substrate binding pocket (H-site) [chemical binding]; other site
648757002619	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
648757002620	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
648757002621	catalytic site [active]
648757002622	G-X2-G-X-G-K; other site
648757002623	YceG-like family; Region: YceG; pfam02618
648757002624	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
648757002625	dimerization interface [polypeptide binding]; other site
648757002626	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
648757002627	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
648757002628	dimer interface [polypeptide binding]; other site
648757002629	active site
648757002630	Phosphopantetheine attachment site; Region: PP-binding; cl09936
648757002631	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
648757002632	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
648757002633	NAD(P) binding site [chemical binding]; other site
648757002634	homotetramer interface [polypeptide binding]; other site
648757002635	homodimer interface [polypeptide binding]; other site
648757002636	active site
648757002637	Acyl transferase domain; Region: Acyl_transf_1; cl08282
648757002638	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
648757002639	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
648757002640	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
648757002641	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
648757002642	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
648757002643	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
648757002644	succinate CoA transferases; Region: YgfH_subfam; TIGR03458
648757002645	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
648757002646	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
648757002647	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
648757002648	transmembrane helices; other site
648757002649	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
648757002650	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
648757002651	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
648757002652	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951
648757002653	replicative DNA helicase; Provisional; Region: PRK09165
648757002654	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
648757002655	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
648757002656	Walker A motif; other site
648757002657	ATP binding site [chemical binding]; other site
648757002658	Walker B motif; other site
648757002659	DNA binding loops [nucleotide binding]
648757002660	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
648757002661	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
648757002662	active site
648757002663	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
648757002664	dimer interface [polypeptide binding]; other site
648757002665	substrate binding site [chemical binding]; other site
648757002666	catalytic residues [active]
648757002667	DNA repair protein RadA; Provisional; Region: PRK11823
648757002668	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
648757002669	Walker A motif/ATP binding site; other site
648757002670	ATP binding site [chemical binding]; other site
648757002671	Walker B motif; other site
648757002672	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
648757002673	Colicin V production protein; Region: Colicin_V; cl00567
648757002674	amidophosphoribosyltransferase; Provisional; Region: PRK09123
648757002675	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
648757002676	active site
648757002677	tetramer interface [polypeptide binding]; other site
648757002678	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
648757002679	active site
648757002680	classical (c) SDRs; Region: SDR_c; cd05233
648757002681	NAD(P) binding site [chemical binding]; other site
648757002682	active site
648757002683	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
648757002684	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
648757002685	Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617
648757002686	PAS fold; Region: PAS_7; pfam12860
648757002687	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
648757002688	dimer interface [polypeptide binding]; other site
648757002689	phosphorylation site [posttranslational modification]
648757002690	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757002691	ATP binding site [chemical binding]; other site
648757002692	Mg2+ binding site [ion binding]; other site
648757002693	G-X-G motif; other site
648757002694	aminopeptidase N; Provisional; Region: pepN; PRK14015
648757002695	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
648757002696	active site
648757002697	Zn binding site [ion binding]; other site
648757002698	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529
648757002699	active site
648757002700	putative DNA-binding cleft [nucleotide binding]; other site
648757002701	dimer interface [polypeptide binding]; other site
648757002702	Cupin domain; Region: Cupin_2; cl09118
648757002703	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
648757002704	RuvA N terminal domain; Region: RuvA_N; pfam01330
648757002705	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
648757002706	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
648757002707	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
648757002708	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
648757002709	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
648757002710	hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391
648757002711	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
648757002712	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
648757002713	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
648757002714	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
648757002715	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
648757002716	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
648757002717	putative substrate-binding site; other site
648757002718	nickel binding site [ion binding]; other site
648757002719	HupF/HypC family; Region: HupF_HypC; cl00394
648757002720	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
648757002721	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
648757002722	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
648757002723	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
648757002724	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
648757002725	hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418
648757002726	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757002727	HupF/HypC family; Region: HupF_HypC; cl00394
648757002728	Hydrogenase formation hypA family; Region: HypD; cl12072
648757002729	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409
648757002730	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
648757002731	dimerization interface [polypeptide binding]; other site
648757002732	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
648757002733	ATP binding site [chemical binding]; other site
648757002734	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
648757002735	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757002736	active site
648757002737	phosphorylation site [posttranslational modification]
648757002738	intermolecular recognition site; other site
648757002739	dimerization interface [polypeptide binding]; other site
648757002740	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
648757002741	Walker A motif; other site
648757002742	ATP binding site [chemical binding]; other site
648757002743	Walker B motif; other site
648757002744	arginine finger; other site
648757002745	Helix-turn-helix domains; Region: HTH; cl00088
648757002746	PAS fold; Region: PAS_4; pfam08448
648757002747	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
648757002748	putative active site [active]
648757002749	heme pocket [chemical binding]; other site
648757002750	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
648757002751	dimer interface [polypeptide binding]; other site
648757002752	phosphorylation site [posttranslational modification]
648757002753	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757002754	ATP binding site [chemical binding]; other site
648757002755	Mg2+ binding site [ion binding]; other site
648757002756	G-X-G motif; other site
648757002757	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
648757002758	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
648757002759	Acylphosphatase; Region: Acylphosphatase; cl00551
648757002760	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
648757002761	HypF finger; Region: zf-HYPF; pfam07503
648757002762	HypF finger; Region: zf-HYPF; pfam07503
648757002763	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
648757002764	Arginase family; Region: Arginase; cl00306
648757002765	Protein of unknown function (DUF1013); Region: DUF1013; cl11533
648757002766	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
648757002767	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
648757002768	Protein of unknown function (DUF1192); Region: DUF1192; cl11573
648757002769	Protein of unknown function (DUF3623); Region: DUF3623; cl11843
648757002770	putative photosynthetic complex assembly protein; Region: photo_alph_chp1; TIGR03054
648757002771	Bacterial PH domain; Region: DUF304; cl01348
648757002772	photosynthetic reaction center, subunit H, bacterial; Region: puhA; TIGR01150
648757002773	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
648757002774	subunit C interaction residues; other site
648757002775	subunit M interaction residues [polypeptide binding]; other site
648757002776	subunit L interaction residues [polypeptide binding]; other site
648757002777	putative proton transfer pathway, P1; other site
648757002778	putative proton transfer pathway, P2; other site
648757002779	PUCC protein; Region: PUCC; pfam03209
648757002780	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
648757002781	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757002782	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
648757002783	S-adenosylmethionine binding site [chemical binding]; other site
648757002784	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757002785	protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185
648757002786	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
648757002787	P-loop; other site
648757002788	magnesium chelatase subunit H; Provisional; Region: bchH; PRK13405
648757002789	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
648757002790	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
648757002791	light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910
648757002792	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
648757002793	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
648757002794	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
648757002795	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
648757002796	2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; cl06353
648757002797	B12 binding domain; Region: B12-binding_2; cl03653
648757002798	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065
648757002799	B12 binding site [chemical binding]; other site
648757002800	transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040
648757002801	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
648757002802	putative active site [active]
648757002803	heme pocket [chemical binding]; other site
648757002804	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
648757002805	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
648757002806	Helix-turn-helix domains; Region: HTH; cl00088
648757002807	UbiA prenyltransferase family; Region: UbiA; cl00337
648757002808	PUCC protein; Region: PUCC; pfam03209
648757002809	geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023
648757002810	TspO/MBR family; Region: TspO_MBR; cl01379
648757002811	Cytochrome c; Region: Cytochrom_C; cl11414
648757002812	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
648757002813	dimerization interface [polypeptide binding]; other site
648757002814	active site
648757002815	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
648757002816	folate binding site [chemical binding]; other site
648757002817	NADP+ binding site [chemical binding]; other site
648757002818	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
648757002819	HflK protein; Region: hflK; TIGR01933
648757002820	HflC protein; Region: hflC; TIGR01932
648757002821	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
648757002822	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
648757002823	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
648757002824	protein binding site [polypeptide binding]; other site
648757002825	Haemolytic domain; Region: Haemolytic; cl00506
648757002826	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
648757002827	dimer interface [polypeptide binding]; other site
648757002828	phosphorylation site [posttranslational modification]
648757002829	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757002830	ATP binding site [chemical binding]; other site
648757002831	Mg2+ binding site [ion binding]; other site
648757002832	G-X-G motif; other site
648757002833	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
648757002834	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
648757002835	OpgC protein; Region: OpgC_C; cl00792
648757002836	Acyltransferase family; Region: Acyl_transf_3; pfam01757
648757002837	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
648757002838	ligand binding site [chemical binding]; other site
648757002839	CAAX protease self-immunity; Region: Abi; cl00558
648757002840	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
648757002841	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
648757002842	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
648757002843	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
648757002844	active site
648757002845	dimer interface [polypeptide binding]; other site
648757002846	motif 1; other site
648757002847	motif 2; other site
648757002848	motif 3; other site
648757002849	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
648757002850	anticodon binding site; other site
648757002851	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
648757002852	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
648757002853	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
648757002854	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
648757002855	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
648757002856	active site
648757002857	NTP binding site [chemical binding]; other site
648757002858	metal binding triad [ion binding]; metal-binding site
648757002859	Protein of unknown function DUF86; Region: DUF86; cl01031
648757002860	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
648757002861	Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509
648757002862	Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509
648757002863	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
648757002864	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
648757002865	intersubunit interface [polypeptide binding]; other site
648757002866	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
648757002867	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
648757002868	ABC-ATPase subunit  interface; other site
648757002869	dimer interface [polypeptide binding]; other site
648757002870	putative PBP binding regions; other site
648757002871	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
648757002872	GAF domain; Region: GAF; cl15785
648757002873	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
648757002874	Walker A motif; other site
648757002875	ATP binding site [chemical binding]; other site
648757002876	Walker B motif; other site
648757002877	arginine finger; other site
648757002878	Helix-turn-helix domains; Region: HTH; cl00088
648757002879	putative alcohol dehydrogenase; Provisional; Region: PRK09860
648757002880	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
648757002881	dimer interface [polypeptide binding]; other site
648757002882	active site
648757002883	metal binding site [ion binding]; metal-binding site
648757002884	Cation efflux family; Region: Cation_efflux; cl00316
648757002885	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
648757002886	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
648757002887	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
648757002888	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
648757002889	serine acetyltransferase; Provisional; Region: cysE; PRK11132
648757002890	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
648757002891	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
648757002892	trimer interface [polypeptide binding]; other site
648757002893	active site
648757002894	substrate binding site [chemical binding]; other site
648757002895	CoA binding site [chemical binding]; other site
648757002896	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
648757002897	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
648757002898	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
648757002899	trimer interface [polypeptide binding]; other site
648757002900	putative metal binding site [ion binding]; other site
648757002901	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
648757002902	FOG: CBS domain [General function prediction only]; Region: COG0517
648757002903	hypothetical protein; Provisional; Region: PRK10279
648757002904	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
648757002905	nucleophile elbow; other site
648757002906	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
648757002907	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
648757002908	GTP cyclohydrolase I; Provisional; Region: PLN03044
648757002909	active site
648757002910	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
648757002911	trimerization site [polypeptide binding]; other site
648757002912	active site
648757002913	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
648757002914	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
648757002915	putative tRNA-binding site [nucleotide binding]; other site
648757002916	B3/4 domain; Region: B3_4; cl11458
648757002917	tRNA synthetase B5 domain; Region: B5; cl08394
648757002918	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
648757002919	dimer interface [polypeptide binding]; other site
648757002920	motif 1; other site
648757002921	motif 3; other site
648757002922	motif 2; other site
648757002923	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
648757002924	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
648757002925	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
648757002926	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
648757002927	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
648757002928	catalytic residues [active]
648757002929	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
648757002930	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
648757002931	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
648757002932	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
648757002933	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
648757002934	DNA binding site [nucleotide binding]
648757002935	Int/Topo IB signature motif; other site
648757002936	active site
648757002937	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
648757002938	non-specific DNA binding site [nucleotide binding]; other site
648757002939	salt bridge; other site
648757002940	sequence-specific DNA binding site [nucleotide binding]; other site
648757002941	CHC2 zinc finger; Region: zf-CHC2; cl15369
648757002942	conjugative transfer relaxase protein TraI; Region: TraI_TIGR; TIGR02760
648757002943	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
648757002944	Domain of unknown function (DUF927); Region: DUF927; cl12098
648757002945	Helix-turn-helix domains; Region: HTH; cl00088
648757002946	Winged helix-turn helix; Region: HTH_29; pfam13551
648757002947	Integrase core domain; Region: rve; cl01316
648757002948	DDE domain; Region: DDE_Tnp_IS240; pfam13610
648757002949	Integrase core domain; Region: rve_3; cl15866
648757002950	Transcriptional regulator [Transcription]; Region: LysR; COG0583
648757002951	Helix-turn-helix domains; Region: HTH; cl00088
648757002952	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
648757002953	putative effector binding pocket; other site
648757002954	putative dimerization interface [polypeptide binding]; other site
648757002955	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
648757002956	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
648757002957	putative NAD(P) binding site [chemical binding]; other site
648757002958	putative substrate binding site [chemical binding]; other site
648757002959	catalytic Zn binding site [ion binding]; other site
648757002960	structural Zn binding site [ion binding]; other site
648757002961	dimer interface [polypeptide binding]; other site
648757002962	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
648757002963	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
648757002964	putative NAD(P) binding site [chemical binding]; other site
648757002965	putative substrate binding site [chemical binding]; other site
648757002966	catalytic Zn binding site [ion binding]; other site
648757002967	structural Zn binding site [ion binding]; other site
648757002968	dimer interface [polypeptide binding]; other site
648757002969	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
648757002970	NADH(P)-binding; Region: NAD_binding_10; pfam13460
648757002971	NAD(P) binding site [chemical binding]; other site
648757002972	putative active site [active]
648757002973	short chain dehydrogenase; Provisional; Region: PRK06940
648757002974	classical (c) SDRs; Region: SDR_c; cd05233
648757002975	NAD(P) binding site [chemical binding]; other site
648757002976	active site
648757002977	Cupin domain; Region: Cupin_2; cl09118
648757002978	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
648757002979	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
648757002980	active site
648757002981	catalytic tetrad [active]
648757002982	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
648757002983	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757002984	NAD(P) binding site [chemical binding]; other site
648757002985	active site
648757002986	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
648757002987	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
648757002988	putative substrate translocation pore; other site
648757002989	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
648757002990	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
648757002991	Cupin domain; Region: Cupin_2; cl09118
648757002992	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
648757002993	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
648757002994	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
648757002995	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
648757002996	VirB7 interaction site; other site
648757002997	VirB8 protein; Region: VirB8; cl01500
648757002998	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
648757002999	Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314; cl02193
648757003000	conjugal transfer protein TrbE; Provisional; Region: PRK13891
648757003001	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
648757003002	Domain of unknown function DUF87; Region: DUF87; pfam01935
648757003003	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757003004	Walker B; other site
648757003005	D-loop; other site
648757003006	H-loop/switch region; other site
648757003007	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
648757003008	TrbC/VIRB2 family; Region: TrbC; cl01583
648757003009	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
648757003010	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
648757003011	ATP binding site [chemical binding]; other site
648757003012	Walker A motif; other site
648757003013	hexamer interface [polypeptide binding]; other site
648757003014	Walker B motif; other site
648757003015	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
648757003016	non-specific DNA binding site [nucleotide binding]; other site
648757003017	salt bridge; other site
648757003018	sequence-specific DNA binding site [nucleotide binding]; other site
648757003019	Protein of unknown function (DUF1778); Region: DUF1778; cl01845
648757003020	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
648757003021	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
648757003022	conjugal transfer coupling protein TraG; Provisional; Region: PRK13880
648757003023	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757003024	Walker A motif; other site
648757003025	ATP binding site [chemical binding]; other site
648757003026	Walker B motif; other site
648757003027	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
648757003028	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
648757003029	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
648757003030	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
648757003031	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
648757003032	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
648757003033	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
648757003034	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583
648757003035	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
648757003036	universal stress protein UspE; Provisional; Region: PRK11175
648757003037	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
648757003038	Ligand Binding Site [chemical binding]; other site
648757003039	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
648757003040	Ligand Binding Site [chemical binding]; other site
648757003041	Na+/H+ ion antiporter subunit; Region: MNHE; cl00807
648757003042	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
648757003043	putative FMN binding site [chemical binding]; other site
648757003044	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
648757003045	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
648757003046	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
648757003047	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
648757003048	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601
648757003049	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
648757003050	active site
648757003051	Protein of unknown function, DUF486; Region: DUF486; cl01236
648757003052	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
648757003053	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
648757003054	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
648757003055	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
648757003056	Walker A/P-loop; other site
648757003057	ATP binding site [chemical binding]; other site
648757003058	Q-loop/lid; other site
648757003059	ABC transporter signature motif; other site
648757003060	Walker B; other site
648757003061	D-loop; other site
648757003062	H-loop/switch region; other site
648757003063	enolase; Provisional; Region: eno; PRK00077
648757003064	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
648757003065	dimer interface [polypeptide binding]; other site
648757003066	metal binding site [ion binding]; metal-binding site
648757003067	substrate binding pocket [chemical binding]; other site
648757003068	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
648757003069	Ligand Binding Site [chemical binding]; other site
648757003070	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
648757003071	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
648757003072	dimerization interface [polypeptide binding]; other site
648757003073	putative DNA binding site [nucleotide binding]; other site
648757003074	putative Zn2+ binding site [ion binding]; other site
648757003075	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
648757003076	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
648757003077	active site
648757003078	nucleotide binding site [chemical binding]; other site
648757003079	HIGH motif; other site
648757003080	KMSKS motif; other site
648757003081	Protein of unknown function (DUF952); Region: DUF952; cl01393
648757003082	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
648757003083	quinone interaction residues [chemical binding]; other site
648757003084	Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167
648757003085	active site
648757003086	catalytic residues [active]
648757003087	FMN binding site [chemical binding]; other site
648757003088	substrate binding site [chemical binding]; other site
648757003089	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
648757003090	homotrimer interface [polypeptide binding]; other site
648757003091	Walker A motif; other site
648757003092	GTP binding site [chemical binding]; other site
648757003093	Walker B motif; other site
648757003094	AAA domain; Region: AAA_26; pfam13500
648757003095	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757003096	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757003097	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
648757003098	iron-sulfur cluster [ion binding]; other site
648757003099	[2Fe-2S] cluster binding site [ion binding]; other site
648757003100	GAF domain; Region: GAF; cl15785
648757003101	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
648757003102	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
648757003103	Walker A motif; other site
648757003104	ATP binding site [chemical binding]; other site
648757003105	Walker B motif; other site
648757003106	arginine finger; other site
648757003107	Helix-turn-helix domains; Region: HTH; cl00088
648757003108	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
648757003109	diiron binding motif [ion binding]; other site
648757003110	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
648757003111	oxidoreductase; Provisional; Region: PRK10015
648757003112	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757003113	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
648757003114	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
648757003115	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
648757003116	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
648757003117	Ligand binding site [chemical binding]; other site
648757003118	Electron transfer flavoprotein domain; Region: ETF; pfam01012
648757003119	Nitrogen fixation protein NifW; Region: NifW; cl03935
648757003120	homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660
648757003121	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
648757003122	active site
648757003123	catalytic residues [active]
648757003124	metal binding site [ion binding]; metal-binding site
648757003125	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
648757003126	active site
648757003127	putative substrate binding region [chemical binding]; other site
648757003128	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
648757003129	homodimer interface [polypeptide binding]; other site
648757003130	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
648757003131	active site pocket [active]
648757003132	glycogen branching enzyme; Provisional; Region: PRK05402
648757003133	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
648757003134	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
648757003135	active site
648757003136	catalytic site [active]
648757003137	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
648757003138	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
648757003139	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
648757003140	ligand binding site; other site
648757003141	oligomer interface; other site
648757003142	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
648757003143	dimer interface [polypeptide binding]; other site
648757003144	N-terminal domain interface [polypeptide binding]; other site
648757003145	sulfate 1 binding site; other site
648757003146	glycogen synthase; Provisional; Region: PRK14099
648757003147	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
648757003148	ADP-binding pocket [chemical binding]; other site
648757003149	homodimer interface [polypeptide binding]; other site
648757003150	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
648757003151	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
648757003152	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
648757003153	active site
648757003154	catalytic site [active]
648757003155	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
648757003156	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
648757003157	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757003158	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
648757003159	ArsC family; Region: ArsC; pfam03960
648757003160	putative catalytic residues [active]
648757003161	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
648757003162	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
648757003163	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
648757003164	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
648757003165	nudix motif; other site
648757003166	PII uridylyl-transferase; Provisional; Region: PRK05092
648757003167	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
648757003168	metal binding triad; other site
648757003169	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
648757003170	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
648757003171	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
648757003172	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
648757003173	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
648757003174	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
648757003175	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
648757003176	Predicted amidohydrolase [General function prediction only]; Region: COG0388
648757003177	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
648757003178	putative active site [active]
648757003179	catalytic triad [active]
648757003180	putative dimer interface [polypeptide binding]; other site
648757003181	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
648757003182	Coenzyme A binding pocket [chemical binding]; other site
648757003183	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
648757003184	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
648757003185	B12 binding site [chemical binding]; other site
648757003186	cobalt ligand [ion binding]; other site
648757003187	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
648757003188	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
648757003189	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
648757003190	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
648757003191	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
648757003192	dimer interface [polypeptide binding]; other site
648757003193	decamer (pentamer of dimers) interface [polypeptide binding]; other site
648757003194	catalytic triad [active]
648757003195	peroxidatic and resolving cysteines [active]
648757003196	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
648757003197	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
648757003198	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
648757003199	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
648757003200	catalytic residues [active]
648757003201	central insert; other site
648757003202	Heme exporter protein D (CcmD); Region: CcmD; cl11475
648757003203	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
648757003204	CcmB protein; Region: CcmB; cl01016
648757003205	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
648757003206	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757003207	Walker A/P-loop; other site
648757003208	ATP binding site [chemical binding]; other site
648757003209	Q-loop/lid; other site
648757003210	ABC transporter signature motif; other site
648757003211	Walker B; other site
648757003212	D-loop; other site
648757003213	H-loop/switch region; other site
648757003214	aconitate hydratase; Validated; Region: PRK09277
648757003215	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
648757003216	substrate binding site [chemical binding]; other site
648757003217	ligand binding site [chemical binding]; other site
648757003218	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
648757003219	substrate binding site [chemical binding]; other site
648757003220	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
648757003221	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
648757003222	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757003223	Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682
648757003224	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
648757003225	ATP-grasp domain; Region: ATP-grasp_4; cl03087
648757003226	osmolarity response regulator; Provisional; Region: ompR; PRK09468
648757003227	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757003228	active site
648757003229	phosphorylation site [posttranslational modification]
648757003230	intermolecular recognition site; other site
648757003231	dimerization interface [polypeptide binding]; other site
648757003232	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
648757003233	DNA binding site [nucleotide binding]
648757003234	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
648757003235	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
648757003236	dimerization interface [polypeptide binding]; other site
648757003237	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
648757003238	dimer interface [polypeptide binding]; other site
648757003239	phosphorylation site [posttranslational modification]
648757003240	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757003241	ATP binding site [chemical binding]; other site
648757003242	Mg2+ binding site [ion binding]; other site
648757003243	G-X-G motif; other site
648757003244	Flagellar protein FlaF; Region: FlaF; cl11454
648757003245	cyclase homology domain; Region: CHD; cd07302
648757003246	nucleotidyl binding site; other site
648757003247	metal binding site [ion binding]; metal-binding site
648757003248	dimer interface [polypeptide binding]; other site
648757003249	TolB amino-terminal domain; Region: TolB_N; cl00639
648757003250	TPR repeat; Region: TPR_11; pfam13414
648757003251	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
648757003252	TPR motif; other site
648757003253	TPR repeat; Region: TPR_11; pfam13414
648757003254	binding surface
648757003255	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
648757003256	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
648757003257	ligand binding site [chemical binding]; other site
648757003258	flexible hinge region; other site
648757003259	Helix-turn-helix domains; Region: HTH; cl00088
648757003260	Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503
648757003261	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
648757003262	active site
648757003263	TspO/MBR family; Region: TspO_MBR; cl01379
648757003264	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
648757003265	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
648757003266	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
648757003267	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
648757003268	active site
648757003269	HIGH motif; other site
648757003270	dimer interface [polypeptide binding]; other site
648757003271	KMSKS motif; other site
648757003272	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
648757003273	Ligand Binding Site [chemical binding]; other site
648757003274	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364
648757003275	NifU-like domain; Region: NifU; cl00484
648757003276	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
648757003277	putative FMN binding site [chemical binding]; other site
648757003278	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
648757003279	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
648757003280	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
648757003281	Coenzyme A binding pocket [chemical binding]; other site
648757003282	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
648757003283	putative acyl-acceptor binding pocket; other site
648757003284	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
648757003285	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
648757003286	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
648757003287	FeS/SAM binding site; other site
648757003288	TRAM domain; Region: TRAM; cl01282
648757003289	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
648757003290	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757003291	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
648757003292	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
648757003293	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
648757003294	Transporter associated domain; Region: CorC_HlyC; cl08393
648757003295	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
648757003296	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
648757003297	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
648757003298	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
648757003299	ABC-2 type transporter; Region: ABC2_membrane; cl11417
648757003300	ABC-2 type transporter; Region: ABC2_membrane; cl11417
648757003301	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
648757003302	The ABCA subfamily mediates the transport of a variety of lipid compounds.  Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263
648757003303	Walker A/P-loop; other site
648757003304	ATP binding site [chemical binding]; other site
648757003305	Q-loop/lid; other site
648757003306	ABC transporter signature motif; other site
648757003307	Walker B; other site
648757003308	D-loop; other site
648757003309	H-loop/switch region; other site
648757003310	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
648757003311	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
648757003312	Walker A/P-loop; other site
648757003313	ATP binding site [chemical binding]; other site
648757003314	Q-loop/lid; other site
648757003315	ABC transporter signature motif; other site
648757003316	Walker B; other site
648757003317	D-loop; other site
648757003318	H-loop/switch region; other site
648757003319	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
648757003320	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
648757003321	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
648757003322	Helix-turn-helix domains; Region: HTH; cl00088
648757003323	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
648757003324	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
648757003325	Proline dehydrogenase; Region: Pro_dh; cl03282
648757003326	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
648757003327	Glutamate binding site [chemical binding]; other site
648757003328	NAD binding site [chemical binding]; other site
648757003329	catalytic residues [active]
648757003330	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
648757003331	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
648757003332	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
648757003333	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
648757003334	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
648757003335	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
648757003336	purine monophosphate binding site [chemical binding]; other site
648757003337	dimer interface [polypeptide binding]; other site
648757003338	putative catalytic residues [active]
648757003339	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
648757003340	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
648757003341	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
648757003342	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
648757003343	Protein of unknown function (DUF541); Region: SIMPL; cl01077
648757003344	LrgB-like family; Region: LrgB; cl00596
648757003345	LrgA family; Region: LrgA; cl00608
648757003346	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
648757003347	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
648757003348	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
648757003349	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
648757003350	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
648757003351	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
648757003352	active site
648757003353	substrate binding site [chemical binding]; other site
648757003354	metal binding site [ion binding]; metal-binding site
648757003355	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
648757003356	dihydropteroate synthase; Region: DHPS; TIGR01496
648757003357	substrate binding pocket [chemical binding]; other site
648757003358	dimer interface [polypeptide binding]; other site
648757003359	inhibitor binding site; inhibition site
648757003360	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
648757003361	Pantoate-beta-alanine ligase; Region: PanC; cd00560
648757003362	pantoate--beta-alanine ligase; Region: panC; TIGR00018
648757003363	active site
648757003364	ATP-binding site [chemical binding]; other site
648757003365	pantoate-binding site; other site
648757003366	HXXH motif; other site
648757003367	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
648757003368	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
648757003369	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
648757003370	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
648757003371	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
648757003372	Helix-turn-helix domains; Region: HTH; cl00088
648757003373	Winged helix-turn helix; Region: HTH_29; pfam13551
648757003374	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
648757003375	salt bridge; other site
648757003376	non-specific DNA binding site [nucleotide binding]; other site
648757003377	sequence-specific DNA binding site [nucleotide binding]; other site
648757003378	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
648757003379	polymerase nucleotide-binding site; other site
648757003380	DNA-binding residues [nucleotide binding]; DNA binding site
648757003381	nucleotide binding site [chemical binding]; other site
648757003382	primase nucleotide-binding site [nucleotide binding]; other site
648757003383	Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707
648757003384	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
648757003385	CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641
648757003386	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
648757003387	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757003388	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
648757003389	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752
648757003390	CRISPR-associated protein Cas8c/Csd1, subtype I-C/DVULG; Region: cas_Csd1; TIGR01863
648757003391	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757
648757003392	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
648757003393	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
648757003394	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721
648757003395	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
648757003396	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
648757003397	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
648757003398	Walker A/P-loop; other site
648757003399	ATP binding site [chemical binding]; other site
648757003400	Q-loop/lid; other site
648757003401	ABC transporter signature motif; other site
648757003402	Walker B; other site
648757003403	D-loop; other site
648757003404	H-loop/switch region; other site
648757003405	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
648757003406	ABC-ATPase subunit  interface; other site
648757003407	dimer interface [polypeptide binding]; other site
648757003408	putative PBP binding regions; other site
648757003409	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
648757003410	ABC-ATPase subunit  interface; other site
648757003411	dimer interface [polypeptide binding]; other site
648757003412	putative PBP binding regions; other site
648757003413	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
648757003414	intersubunit interface [polypeptide binding]; other site
648757003415	enterobactin receptor protein; Provisional; Region: PRK13483
648757003416	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
648757003417	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
648757003418	N-terminal plug; other site
648757003419	ligand-binding site [chemical binding]; other site
648757003420	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424
648757003421	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
648757003422	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
648757003423	FAD binding pocket [chemical binding]; other site
648757003424	FAD binding motif [chemical binding]; other site
648757003425	phosphate binding motif [ion binding]; other site
648757003426	NAD binding pocket [chemical binding]; other site
648757003427	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
648757003428	Helix-turn-helix domains; Region: HTH; cl00088
648757003429	Winged helix-turn helix; Region: HTH_29; pfam13551
648757003430	Integrase core domain; Region: rve; cl01316
648757003431	DDE domain; Region: DDE_Tnp_IS240; pfam13610
648757003432	Integrase core domain; Region: rve_3; cl15866
648757003433	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
648757003434	FecR protein; Region: FecR; pfam04773
648757003435	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
648757003436	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
648757003437	DNA binding residues [nucleotide binding]
648757003438	Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042
648757003439	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
648757003440	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
648757003441	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
648757003442	active site
648757003443	metal binding site [ion binding]; metal-binding site
648757003444	Transposase domain (DUF772); Region: DUF772; cl15789
648757003445	Transposase domain (DUF772); Region: DUF772; cl15789
648757003446	Helix-turn-helix domains; Region: HTH; cl00088
648757003447	Winged helix-turn helix; Region: HTH_29; pfam13551
648757003448	Integrase core domain; Region: rve; cl01316
648757003449	DDE domain; Region: DDE_Tnp_IS240; pfam13610
648757003450	Integrase core domain; Region: rve_3; cl15866
648757003451	Transposase domain (DUF772); Region: DUF772; cl15789
648757003452	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
648757003453	Transposase domain (DUF772); Region: DUF772; cl15789
648757003454	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
648757003455	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
648757003456	Sel1 repeat; Region: Sel1; cl02723
648757003457	Sel1 repeat; Region: Sel1; cl02723
648757003458	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
648757003459	transposase/IS protein; Provisional; Region: PRK09183
648757003460	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
648757003461	Walker A motif; other site
648757003462	ATP binding site [chemical binding]; other site
648757003463	Walker B motif; other site
648757003464	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
648757003465	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
648757003466	ligand binding site [chemical binding]; other site
648757003467	Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042
648757003468	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
648757003469	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190
648757003470	cleavage site
648757003471	active site
648757003472	substrate binding sites [chemical binding]; other site
648757003473	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
648757003474	SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137
648757003475	reactive center loop; other site
648757003476	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
648757003477	binding surface
648757003478	TPR motif; other site
648757003479	TPR repeat; Region: TPR_11; pfam13414
648757003480	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
648757003481	binding surface
648757003482	TPR motif; other site
648757003483	Tetratricopeptide repeat; Region: TPR_16; pfam13432
648757003484	Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042
648757003485	integrase; Provisional; Region: PRK09692
648757003486	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
648757003487	active site
648757003488	Int/Topo IB signature motif; other site
648757003489	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
648757003490	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
648757003491	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
648757003492	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
648757003493	active site
648757003494	nucleophile elbow; other site
648757003495	Methyltransferase domain; Region: Methyltransf_31; pfam13847
648757003496	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
648757003497	S-adenosylmethionine binding site [chemical binding]; other site
648757003498	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757003499	RNA polymerase sigma factor; Provisional; Region: PRK12540
648757003500	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
648757003501	DNA binding residues [nucleotide binding]
648757003502	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
648757003503	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
648757003504	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
648757003505	putative active site [active]
648757003506	putative substrate binding site [chemical binding]; other site
648757003507	putative cosubstrate binding site; other site
648757003508	catalytic site [active]
648757003509	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
648757003510	Cation efflux family; Region: Cation_efflux; cl00316
648757003511	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
648757003512	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
648757003513	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
648757003514	AP (apurinic/apyrimidinic) site pocket; other site
648757003515	DNA interaction; other site
648757003516	Metal-binding active site; metal-binding site
648757003517	aspartate aminotransferase; Provisional; Region: PRK05764
648757003518	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
648757003519	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757003520	homodimer interface [polypeptide binding]; other site
648757003521	catalytic residue [active]
648757003522	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
648757003523	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
648757003524	S-adenosylmethionine binding site [chemical binding]; other site
648757003525	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
648757003526	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
648757003527	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
648757003528	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
648757003529	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
648757003530	active site
648757003531	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
648757003532	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
648757003533	S-adenosylmethionine binding site [chemical binding]; other site
648757003534	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
648757003535	Protein of unknown function, DUF482; Region: DUF482; pfam04339
648757003536	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
648757003537	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
648757003538	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
648757003539	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
648757003540	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
648757003541	The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218
648757003542	Walker A/P-loop; other site
648757003543	ATP binding site [chemical binding]; other site
648757003544	Q-loop/lid; other site
648757003545	ABC transporter signature motif; other site
648757003546	Walker B; other site
648757003547	D-loop; other site
648757003548	H-loop/switch region; other site
648757003549	OstA-like protein; Region: OstA; cl00844
648757003550	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
648757003551	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
648757003552	putative active site [active]
648757003553	catalytic site [active]
648757003554	putative substrate binding site [chemical binding]; other site
648757003555	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
648757003556	Cytochrome c; Region: Cytochrom_C; cl11414
648757003557	Helix-turn-helix domains; Region: HTH; cl00088
648757003558	Winged helix-turn helix; Region: HTH_29; pfam13551
648757003559	Helix-turn-helix domains; Region: HTH; cl00088
648757003560	Integrase core domain; Region: rve; cl01316
648757003561	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
648757003562	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
648757003563	intrachain domain interface; other site
648757003564	Qi binding site; other site
648757003565	interchain domain interface [polypeptide binding]; other site
648757003566	cytochrome b; Provisional; Region: CYTB; MTH00156
648757003567	heme bH binding site [chemical binding]; other site
648757003568	heme bL binding site [chemical binding]; other site
648757003569	Qo binding site; other site
648757003570	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
648757003571	interchain domain interface [polypeptide binding]; other site
648757003572	intrachain domain interface; other site
648757003573	Qi binding site; other site
648757003574	Qo binding site; other site
648757003575	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
648757003576	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
648757003577	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
648757003578	[2Fe-2S] cluster binding site [ion binding]; other site
648757003579	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
648757003580	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433
648757003581	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
648757003582	IHF dimer interface [polypeptide binding]; other site
648757003583	IHF - DNA interface [nucleotide binding]; other site
648757003584	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
648757003585	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
648757003586	dimer interface [polypeptide binding]; other site
648757003587	active site
648757003588	CoA binding pocket [chemical binding]; other site
648757003589	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
648757003590	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
648757003591	Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045
648757003592	SmpA / OmlA family; Region: SmpA_OmlA; cl01095
648757003593	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
648757003594	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
648757003595	dimerization interface [polypeptide binding]; other site
648757003596	putative ATP binding site [chemical binding]; other site
648757003597	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
648757003598	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
648757003599	active site
648757003600	substrate binding site [chemical binding]; other site
648757003601	cosubstrate binding site; other site
648757003602	catalytic site [active]
648757003603	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
648757003604	putative di-iron ligands [ion binding]; other site
648757003605	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
648757003606	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
648757003607	dimer interface [polypeptide binding]; other site
648757003608	active site
648757003609	CoA binding pocket [chemical binding]; other site
648757003610	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
648757003611	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
648757003612	active site
648757003613	homotetramer interface [polypeptide binding]; other site
648757003614	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
648757003615	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
648757003616	putative active site [active]
648757003617	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
648757003618	glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480
648757003619	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
648757003620	active site
648757003621	tetramer interface; other site
648757003622	Transglycosylase SLT domain; Region: SLT_2; pfam13406
648757003623	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
648757003624	N-acetyl-D-glucosamine binding site [chemical binding]; other site
648757003625	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
648757003626	active site
648757003627	catalytic triad [active]
648757003628	oxyanion hole [active]
648757003629	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
648757003630	active site
648757003631	oxyanion hole [active]
648757003632	catalytic triad [active]
648757003633	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
648757003634	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
648757003635	HflX GTPase family; Region: HflX; cd01878
648757003636	G1 box; other site
648757003637	GTP/Mg2+ binding site [chemical binding]; other site
648757003638	Switch I region; other site
648757003639	G2 box; other site
648757003640	G3 box; other site
648757003641	Switch II region; other site
648757003642	G4 box; other site
648757003643	G5 box; other site
648757003644	Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716
648757003645	Sm1 motif; other site
648757003646	intra - hexamer interaction site; other site
648757003647	inter - hexamer interaction site [polypeptide binding]; other site
648757003648	nucleotide binding pocket [chemical binding]; other site
648757003649	Sm2 motif; other site
648757003650	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
648757003651	homodimer interface [polypeptide binding]; other site
648757003652	substrate-cofactor binding pocket; other site
648757003653	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757003654	catalytic residue [active]
648757003655	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
648757003656	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757003657	active site
648757003658	phosphorylation site [posttranslational modification]
648757003659	intermolecular recognition site; other site
648757003660	dimerization interface [polypeptide binding]; other site
648757003661	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
648757003662	Walker A motif; other site
648757003663	ATP binding site [chemical binding]; other site
648757003664	Walker B motif; other site
648757003665	arginine finger; other site
648757003666	Helix-turn-helix domains; Region: HTH; cl00088
648757003667	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
648757003668	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
648757003669	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
648757003670	dimer interface [polypeptide binding]; other site
648757003671	phosphorylation site [posttranslational modification]
648757003672	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757003673	ATP binding site [chemical binding]; other site
648757003674	Mg2+ binding site [ion binding]; other site
648757003675	G-X-G motif; other site
648757003676	lipoyl synthase; Provisional; Region: PRK05481
648757003677	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
648757003678	putative coenzyme Q binding site [chemical binding]; other site
648757003679	Competence-damaged protein; Region: CinA; cl00666
648757003680	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
648757003681	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
648757003682	substrate binding site; other site
648757003683	dimer interface; other site
648757003684	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
648757003685	homotrimer interaction site [polypeptide binding]; other site
648757003686	zinc binding site [ion binding]; other site
648757003687	CDP-binding sites; other site
648757003688	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
648757003689	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
648757003690	dimer interface [polypeptide binding]; other site
648757003691	phosphorylation site [posttranslational modification]
648757003692	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757003693	ATP binding site [chemical binding]; other site
648757003694	Mg2+ binding site [ion binding]; other site
648757003695	G-X-G motif; other site
648757003696	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
648757003697	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757003698	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
648757003699	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
648757003700	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
648757003701	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
648757003702	E3 interaction surface; other site
648757003703	lipoyl attachment site [posttranslational modification]; other site
648757003704	e3 binding domain; Region: E3_binding; pfam02817
648757003705	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
648757003706	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
648757003707	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
648757003708	E3 interaction surface; other site
648757003709	lipoyl attachment site [posttranslational modification]; other site
648757003710	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
648757003711	alpha subunit interface [polypeptide binding]; other site
648757003712	TPP binding site [chemical binding]; other site
648757003713	heterodimer interface [polypeptide binding]; other site
648757003714	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
648757003715	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
648757003716	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
648757003717	tetramer interface [polypeptide binding]; other site
648757003718	TPP-binding site [chemical binding]; other site
648757003719	heterodimer interface [polypeptide binding]; other site
648757003720	phosphorylation loop region [posttranslational modification]
648757003721	Septum formation initiator; Region: DivIC; cl11433
648757003722	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
648757003723	intracellular protease, PfpI family; Region: PfpI; TIGR01382
648757003724	proposed catalytic triad [active]
648757003725	conserved cys residue [active]
648757003726	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
648757003727	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
648757003728	dimer interface [polypeptide binding]; other site
648757003729	ADP-ribose binding site [chemical binding]; other site
648757003730	active site
648757003731	nudix motif; other site
648757003732	metal binding site [ion binding]; metal-binding site
648757003733	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
648757003734	ADP-ribose binding site [chemical binding]; other site
648757003735	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
648757003736	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
648757003737	Transcriptional regulators [Transcription]; Region: GntR; COG1802
648757003738	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
648757003739	DNA-binding site [nucleotide binding]; DNA binding site
648757003740	FCD domain; Region: FCD; cl11656
648757003741	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
648757003742	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
648757003743	glutathionine S-transferase; Provisional; Region: PRK10542
648757003744	C-terminal domain interface [polypeptide binding]; other site
648757003745	GSH binding site (G-site) [chemical binding]; other site
648757003746	dimer interface [polypeptide binding]; other site
648757003747	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
648757003748	dimer interface [polypeptide binding]; other site
648757003749	substrate binding pocket (H-site) [chemical binding]; other site
648757003750	N-terminal domain interface [polypeptide binding]; other site
648757003751	Helix-turn-helix domains; Region: HTH; cl00088
648757003752	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
648757003753	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
648757003754	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
648757003755	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
648757003756	Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526
648757003757	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
648757003758	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
648757003759	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
648757003760	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
648757003761	dimer interface [polypeptide binding]; other site
648757003762	conserved gate region; other site
648757003763	putative PBP binding loops; other site
648757003764	ABC-ATPase subunit interface; other site
648757003765	sulfate transport protein; Provisional; Region: cysT; CHL00187
648757003766	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
648757003767	dimer interface [polypeptide binding]; other site
648757003768	conserved gate region; other site
648757003769	putative PBP binding loops; other site
648757003770	ABC-ATPase subunit interface; other site
648757003771	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
648757003772	Part of the ABC transporter complex cysAWTP involved in sulfate import.  Responsible for energy coupling to the transport system.  The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296
648757003773	Walker A/P-loop; other site
648757003774	ATP binding site [chemical binding]; other site
648757003775	Q-loop/lid; other site
648757003776	ABC transporter signature motif; other site
648757003777	Walker B; other site
648757003778	D-loop; other site
648757003779	H-loop/switch region; other site
648757003780	TOBE-like domain; Region: TOBE_3; pfam12857
648757003781	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
648757003782	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
648757003783	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
648757003784	Walker A/P-loop; other site
648757003785	ATP binding site [chemical binding]; other site
648757003786	Q-loop/lid; other site
648757003787	ABC transporter signature motif; other site
648757003788	Walker B; other site
648757003789	D-loop; other site
648757003790	H-loop/switch region; other site
648757003791	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
648757003792	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
648757003793	ligand binding site [chemical binding]; other site
648757003794	Protein of unknown function DUF45; Region: DUF45; cl00636
648757003795	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
648757003796	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
648757003797	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
648757003798	MltA-interacting protein MipA; Region: MipA; cl01504
648757003799	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
648757003800	Integral membrane protein TerC family; Region: TerC; cl10468
648757003801	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
648757003802	CutA1 divalent ion tolerance protein; Region: CutA1; cl00584
648757003803	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
648757003804	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
648757003805	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
648757003806	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
648757003807	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
648757003808	EamA-like transporter family; Region: EamA; cl01037
648757003809	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
648757003810	oligomeric interface; other site
648757003811	putative active site [active]
648757003812	homodimer interface [polypeptide binding]; other site
648757003813	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
648757003814	ABC-2 type transporter; Region: ABC2_membrane; cl11417
648757003815	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
648757003816	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
648757003817	Walker A/P-loop; other site
648757003818	ATP binding site [chemical binding]; other site
648757003819	Q-loop/lid; other site
648757003820	ABC transporter signature motif; other site
648757003821	Walker B; other site
648757003822	D-loop; other site
648757003823	H-loop/switch region; other site
648757003824	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757003825	PIF1-like helicase; Region: PIF1; pfam05970
648757003826	Family description; Region: UvrD_C_2; cl15862
648757003827	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
648757003828	NodB motif; other site
648757003829	active site
648757003830	catalytic site [active]
648757003831	metal binding site [ion binding]; metal-binding site
648757003832	DASH complex subunit Spc34; Region: DASH_Spc34; pfam08657
648757003833	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
648757003834	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435
648757003835	oligomerization interface [polypeptide binding]; other site
648757003836	active site
648757003837	metal binding site [ion binding]; metal-binding site
648757003838	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589
648757003839	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
648757003840	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
648757003841	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
648757003842	catalytic triad [active]
648757003843	Uncharacterized conserved protein [Function unknown]; Region: COG1432
648757003844	LabA_like proteins; Region: LabA; cd10911
648757003845	putative metal binding site [ion binding]; other site
648757003846	phosphoglucomutase; Region: PLN02307
648757003847	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
648757003848	active site
648757003849	substrate binding site [chemical binding]; other site
648757003850	metal binding site [ion binding]; metal-binding site
648757003851	osmolarity response regulator; Provisional; Region: ompR; PRK09468
648757003852	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757003853	active site
648757003854	phosphorylation site [posttranslational modification]
648757003855	intermolecular recognition site; other site
648757003856	dimerization interface [polypeptide binding]; other site
648757003857	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
648757003858	DNA binding site [nucleotide binding]
648757003859	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
648757003860	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
648757003861	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
648757003862	dimer interface [polypeptide binding]; other site
648757003863	phosphorylation site [posttranslational modification]
648757003864	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757003865	ATP binding site [chemical binding]; other site
648757003866	Mg2+ binding site [ion binding]; other site
648757003867	G-X-G motif; other site
648757003868	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
648757003869	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
648757003870	CAP-like domain; other site
648757003871	active site
648757003872	primary dimer interface [polypeptide binding]; other site
648757003873	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
648757003874	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
648757003875	LexA repressor; Validated; Region: PRK00215
648757003876	Helix-turn-helix domains; Region: HTH; cl00088
648757003877	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
648757003878	Catalytic site [active]
648757003879	putative transporter; Provisional; Region: PRK10504
648757003880	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
648757003881	putative substrate translocation pore; other site
648757003882	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
648757003883	ATP-grasp domain; Region: ATP-grasp_4; cl03087
648757003884	oligopeptide transporters, OPT superfamily; Region: OPT_sfam; TIGR00728
648757003885	OPT oligopeptide transporter protein; Region: OPT; cl14607
648757003886	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
648757003887	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
648757003888	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
648757003889	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
648757003890	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
648757003891	dimer interface [polypeptide binding]; other site
648757003892	conserved gate region; other site
648757003893	putative PBP binding loops; other site
648757003894	ABC-ATPase subunit interface; other site
648757003895	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
648757003896	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
648757003897	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757003898	Walker A/P-loop; other site
648757003899	ATP binding site [chemical binding]; other site
648757003900	Q-loop/lid; other site
648757003901	ABC transporter signature motif; other site
648757003902	Walker B; other site
648757003903	D-loop; other site
648757003904	H-loop/switch region; other site
648757003905	TOBE domain; Region: TOBE_2; cl01440
648757003906	Fic family protein [Function unknown]; Region: COG3177
648757003907	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
648757003908	Fic/DOC family; Region: Fic; cl00960
648757003909	Helix-turn-helix domains; Region: HTH; cl00088
648757003910	AIPR protein; Region: AIPR; pfam10592
648757003911	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
648757003912	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
648757003913	Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584
648757003914	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757003915	Walker A motif; other site
648757003916	ATP binding site [chemical binding]; other site
648757003917	Walker B motif; other site
648757003918	Peptidase family M48; Region: Peptidase_M48; cl12018
648757003919	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
648757003920	active site clefts [active]
648757003921	zinc binding site [ion binding]; other site
648757003922	dimer interface [polypeptide binding]; other site
648757003923	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
648757003924	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757003925	Domain of unknown function (DUF955); Region: DUF955; cl01076
648757003926	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
648757003927	P63C domain; Region: P63C; pfam10546
648757003928	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
648757003929	HEAT repeats; Region: HEAT_2; pfam13646
648757003930	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
648757003931	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
648757003932	Integrase core domain; Region: rve; cl01316
648757003933	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
648757003934	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
648757003935	Helix-turn-helix domains; Region: HTH; cl00088
648757003936	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
648757003937	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
648757003938	Helix-turn-helix domains; Region: HTH; cl00088
648757003939	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
648757003940	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
648757003941	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
648757003942	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
648757003943	Integrase core domain; Region: rve; cl01316
648757003944	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
648757003945	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
648757003946	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
648757003947	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
648757003948	S1/P1 Nuclease; Region: S1-P1_nuclease; pfam02265
648757003949	Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783
648757003950	Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041
648757003951	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
648757003952	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
648757003953	P-loop; other site
648757003954	Magnesium ion binding site [ion binding]; other site
648757003955	Plasmid encoded RepA protein; Region: RepA_C; pfam04796
648757003956	RloB-like protein; Region: RloB; pfam13707
648757003957	AAA domain; Region: AAA_21; pfam13304
648757003958	ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules.  The...; Region: ABC_ATPase; cd00267
648757003959	ABC transporter signature motif; other site
648757003960	Walker B; other site
648757003961	D-loop; other site
648757003962	H-loop/switch region; other site
648757003963	Fic family protein [Function unknown]; Region: COG3177
648757003964	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
648757003965	Fic/DOC family; Region: Fic; cl00960
648757003966	Helix-turn-helix domains; Region: HTH; cl00088
648757003967	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
648757003968	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
648757003969	DNA binding site [nucleotide binding]
648757003970	Int/Topo IB signature motif; other site
648757003971	active site
648757003972	Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219
648757003973	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
648757003974	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
648757003975	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
648757003976	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
648757003977	RecT family; Region: RecT; cl04285
648757003978	YqaJ-like viral recombinase domain; Region: YqaJ; cl09232
648757003979	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
648757003980	GcrA cell cycle regulator; Region: GcrA; cl11564
648757003981	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
648757003982	ATP binding site [chemical binding]; other site
648757003983	putative Mg++ binding site [ion binding]; other site
648757003984	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
648757003985	nucleotide binding region [chemical binding]; other site
648757003986	ATP-binding site [chemical binding]; other site
648757003987	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
648757003988	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
648757003989	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
648757003990	active site
648757003991	metal binding site [ion binding]; metal-binding site
648757003992	interdomain interaction site; other site
648757003993	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
648757003994	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
648757003995	Integrase core domain; Region: rve; cl01316
648757003996	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
648757003997	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
648757003998	Helix-turn-helix domains; Region: HTH; cl00088
648757003999	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
648757004000	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
648757004001	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
648757004002	additional DNA contacts [nucleotide binding]; other site
648757004003	mismatch recognition site; other site
648757004004	active site
648757004005	zinc binding site [ion binding]; other site
648757004006	DNA intercalation site [nucleotide binding]; other site
648757004007	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
648757004008	DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323
648757004009	Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine; Region: Bromodomain; cl02556
648757004010	acetyllysine binding site; other site
648757004011	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
648757004012	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
648757004013	cofactor binding site; other site
648757004014	DNA binding site [nucleotide binding]
648757004015	substrate interaction site [chemical binding]; other site
648757004016	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757004017	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
648757004018	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
648757004019	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
648757004020	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757004021	Walker A/P-loop; other site
648757004022	ATP binding site [chemical binding]; other site
648757004023	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
648757004024	putative active site [active]
648757004025	putative metal-binding site [ion binding]; other site
648757004026	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757004027	Family description; Region: UvrD_C_2; cl15862
648757004028	BRO family, N-terminal domain; Region: Bro-N; cl10591
648757004029	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
648757004030	Helix-turn-helix domains; Region: HTH; cl00088
648757004031	Winged helix-turn helix; Region: HTH_29; pfam13551
648757004032	Integrase core domain; Region: rve; cl01316
648757004033	DDE domain; Region: DDE_Tnp_IS240; pfam13610
648757004034	Integrase core domain; Region: rve_3; cl15866
648757004035	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
648757004036	ligand binding site [chemical binding]; other site
648757004037	Helix-turn-helix domains; Region: HTH; cl00088
648757004038	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
648757004039	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
648757004040	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
648757004041	Integrase core domain; Region: rve; cl01316
648757004042	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
648757004043	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
648757004044	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
648757004045	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
648757004046	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
648757004047	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
648757004048	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
648757004049	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757004050	active site
648757004051	phosphorylation site [posttranslational modification]
648757004052	intermolecular recognition site; other site
648757004053	dimerization interface [polypeptide binding]; other site
648757004054	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
648757004055	DNA binding residues [nucleotide binding]
648757004056	dimerization interface [polypeptide binding]; other site
648757004057	PAS fold; Region: PAS_2; pfam08446
648757004058	GAF domain; Region: GAF; cl15785
648757004059	Phytochrome region; Region: PHY; pfam00360
648757004060	Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]; Region: UhpB; COG3851
648757004061	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757004062	ATP binding site [chemical binding]; other site
648757004063	Mg2+ binding site [ion binding]; other site
648757004064	G-X-G motif; other site
648757004065	PAS fold; Region: PAS_3; pfam08447
648757004066	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
648757004067	putative active site [active]
648757004068	heme pocket [chemical binding]; other site
648757004069	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
648757004070	PAS domain; Region: PAS_9; pfam13426
648757004071	putative active site [active]
648757004072	heme pocket [chemical binding]; other site
648757004073	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
648757004074	dimer interface [polypeptide binding]; other site
648757004075	phosphorylation site [posttranslational modification]
648757004076	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757004077	ATP binding site [chemical binding]; other site
648757004078	Mg2+ binding site [ion binding]; other site
648757004079	G-X-G motif; other site
648757004080	Response regulator receiver domain; Region: Response_reg; pfam00072
648757004081	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757004082	active site
648757004083	phosphorylation site [posttranslational modification]
648757004084	intermolecular recognition site; other site
648757004085	dimerization interface [polypeptide binding]; other site
648757004086	circadian clock protein KaiC; Reviewed; Region: PRK09302
648757004087	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757004088	ATP binding site [chemical binding]; other site
648757004089	Walker A motif; other site
648757004090	Walker B motif; other site
648757004091	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757004092	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757004093	Walker A motif; other site
648757004094	ATP binding site [chemical binding]; other site
648757004095	Walker B motif; other site
648757004096	Domain of unknown function (DUF1989); Region: DUF1989; cl01474
648757004097	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
648757004098	YqcI/YcgG family; Region: YqcI_YcgG; cl01349
648757004099	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
648757004100	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757004101	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
648757004102	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
648757004103	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
648757004104	active site
648757004105	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
648757004106	phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324
648757004107	Walker A/P-loop; other site
648757004108	ATP binding site [chemical binding]; other site
648757004109	Q-loop/lid; other site
648757004110	ABC transporter signature motif; other site
648757004111	Walker B; other site
648757004112	D-loop; other site
648757004113	H-loop/switch region; other site
648757004114	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
648757004115	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
648757004116	Walker A/P-loop; other site
648757004117	ATP binding site [chemical binding]; other site
648757004118	Q-loop/lid; other site
648757004119	ABC transporter signature motif; other site
648757004120	Walker B; other site
648757004121	D-loop; other site
648757004122	H-loop/switch region; other site
648757004123	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
648757004124	Phosphonate metabolism protein PhnJ; Region: PhnJ; cl01457
648757004125	Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; cl01456
648757004126	Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; cl01455
648757004127	Phosphonate metabolism protein PhnG; Region: PhnG; cl01454
648757004128	phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308
648757004129	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
648757004130	trimer interface [polypeptide binding]; other site
648757004131	active site
648757004132	substrate binding site [chemical binding]; other site
648757004133	CoA binding site [chemical binding]; other site
648757004134	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
648757004135	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
648757004136	dimer interface [polypeptide binding]; other site
648757004137	conserved gate region; other site
648757004138	putative PBP binding loops; other site
648757004139	ABC-ATPase subunit interface; other site
648757004140	NMT1-like family; Region: NMT1_2; cl15260
648757004141	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
648757004142	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
648757004143	ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond.  Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256
648757004144	Walker A/P-loop; other site
648757004145	ATP binding site [chemical binding]; other site
648757004146	Q-loop/lid; other site
648757004147	ABC transporter signature motif; other site
648757004148	Walker B; other site
648757004149	D-loop; other site
648757004150	H-loop/switch region; other site
648757004151	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
648757004152	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
648757004153	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
648757004154	cobyric acid synthase; Provisional; Region: PRK00784
648757004155	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757004156	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
648757004157	catalytic triad [active]
648757004158	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
648757004159	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
648757004160	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757004161	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
648757004162	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321
648757004163	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
648757004164	Helix-turn-helix domains; Region: HTH; cl00088
648757004165	Integrase core domain; Region: rve; cl01316
648757004166	Gram-negative bacterial tonB protein; Region: TonB; cl10048
648757004167	Protein of unknown function (DUF1810); Region: DUF1810; cl02370
648757004168	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
648757004169	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433
648757004170	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
648757004171	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
648757004172	C-terminal domain interface [polypeptide binding]; other site
648757004173	GSH binding site (G-site) [chemical binding]; other site
648757004174	dimer interface [polypeptide binding]; other site
648757004175	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
648757004176	N-terminal domain interface [polypeptide binding]; other site
648757004177	putative dimer interface [polypeptide binding]; other site
648757004178	active site
648757004179	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
648757004180	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
648757004181	C-terminal domain interface [polypeptide binding]; other site
648757004182	GSH binding site (G-site) [chemical binding]; other site
648757004183	dimer interface [polypeptide binding]; other site
648757004184	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
648757004185	N-terminal domain interface [polypeptide binding]; other site
648757004186	dimer interface [polypeptide binding]; other site
648757004187	substrate binding pocket (H-site) [chemical binding]; other site
648757004188	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
648757004189	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
648757004190	active site
648757004191	motif I; other site
648757004192	motif II; other site
648757004193	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
648757004194	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757004195	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
648757004196	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
648757004197	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757004198	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
648757004199	ATP synthase A chain; Region: ATP-synt_A; cl00413
648757004200	ATP synthase subunit C; Region: ATP-synt_C; cl00466
648757004201	Plant ATP synthase F0; Region: YMF19; cl07975
648757004202	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
648757004203	Plant ATP synthase F0; Region: YMF19; cl07975
648757004204	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
648757004205	DNA-binding site [nucleotide binding]; DNA binding site
648757004206	RNA-binding motif; other site
648757004207	GTPase CgtA; Reviewed; Region: obgE; PRK12299
648757004208	GTP1/OBG; Region: GTP1_OBG; pfam01018
648757004209	Obg GTPase; Region: Obg; cd01898
648757004210	G1 box; other site
648757004211	GTP/Mg2+ binding site [chemical binding]; other site
648757004212	Switch I region; other site
648757004213	G2 box; other site
648757004214	G3 box; other site
648757004215	Switch II region; other site
648757004216	G4 box; other site
648757004217	G5 box; other site
648757004218	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
648757004219	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
648757004220	NAD(P) binding site [chemical binding]; other site
648757004221	catalytic residues [active]
648757004222	Gram-negative bacterial tonB protein; Region: TonB; cl10048
648757004223	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
648757004224	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
648757004225	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
648757004226	active site
648757004227	WYL domain; Region: WYL; cl14852
648757004228	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533
648757004229	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757004230	NAD(P) binding site [chemical binding]; other site
648757004231	active site
648757004232	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
648757004233	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
648757004234	dimer interface [polypeptide binding]; other site
648757004235	Alkaline phosphatase homologues; Region: alkPPc; smart00098
648757004236	active site
648757004237	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
648757004238	putative substrate translocation pore; other site
648757004239	metabolite-proton symporter; Region: 2A0106; TIGR00883
648757004240	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
648757004241	Malic enzyme, N-terminal domain; Region: malic; pfam00390
648757004242	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
648757004243	putative NAD(P) binding site [chemical binding]; other site
648757004244	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
648757004245	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
648757004246	dimer interface [polypeptide binding]; other site
648757004247	[2Fe-2S] cluster binding site [ion binding]; other site
648757004248	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
648757004249	iron-sulfur cluster [ion binding]; other site
648757004250	[2Fe-2S] cluster binding site [ion binding]; other site
648757004251	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
648757004252	Rhomboid family; Region: Rhomboid; cl11446
648757004253	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
648757004254	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
648757004255	Uncharacterized conserved protein [Function unknown]; Region: COG2308
648757004256	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503
648757004257	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980
648757004258	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494
648757004259	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
648757004260	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
648757004261	Walker A motif; other site
648757004262	ATP binding site [chemical binding]; other site
648757004263	Walker B motif; other site
648757004264	arginine finger; other site
648757004265	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
648757004266	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
648757004267	CHAD domain; Region: CHAD; cl10506
648757004268	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
648757004269	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
648757004270	putative active site [active]
648757004271	putative metal binding site [ion binding]; other site
648757004272	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
648757004273	feedback inhibition sensing region; other site
648757004274	homohexameric interface [polypeptide binding]; other site
648757004275	nucleotide binding site [chemical binding]; other site
648757004276	N-acetyl-L-glutamate binding site [chemical binding]; other site
648757004277	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
648757004278	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
648757004279	motif II; other site
648757004280	seryl-tRNA synthetase; Provisional; Region: PRK05431
648757004281	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
648757004282	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770
648757004283	dimer interface [polypeptide binding]; other site
648757004284	active site
648757004285	motif 1; other site
648757004286	motif 2; other site
648757004287	motif 3; other site
648757004288	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
648757004289	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
648757004290	NADP binding site [chemical binding]; other site
648757004291	dimer interface [polypeptide binding]; other site
648757004292	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
648757004293	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
648757004294	GatB domain; Region: GatB_Yqey; cl11497
648757004295	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; cl01930
648757004296	Chorismate mutase type II; Region: CM_2; cl00693
648757004297	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
648757004298	Amidase; Region: Amidase; cl11426
648757004299	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
648757004300	Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230
648757004301	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
648757004302	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
648757004303	putative active site [active]
648757004304	metal binding site [ion binding]; metal-binding site
648757004305	homodimer binding site [polypeptide binding]; other site
648757004306	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
648757004307	DoxX; Region: DoxX; cl00976
648757004308	Cell division protein ZapA; Region: ZapA; cl01146
648757004309	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
648757004310	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
648757004311	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
648757004312	putative NAD(P) binding site [chemical binding]; other site
648757004313	putative substrate binding site [chemical binding]; other site
648757004314	catalytic Zn binding site [ion binding]; other site
648757004315	structural Zn binding site [ion binding]; other site
648757004316	dimer interface [polypeptide binding]; other site
648757004317	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
648757004318	active site
648757004319	DNA binding site [nucleotide binding]
648757004320	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
648757004321	dimer interaction site [polypeptide binding]; other site
648757004322	substrate-binding tunnel; other site
648757004323	active site
648757004324	catalytic site [active]
648757004325	substrate binding site [chemical binding]; other site
648757004326	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
648757004327	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
648757004328	active site
648757004329	Riboflavin kinase; Region: Flavokinase; cl03312
648757004330	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
648757004331	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
648757004332	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
648757004333	dimer interface [polypeptide binding]; other site
648757004334	phosphorylation site [posttranslational modification]
648757004335	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757004336	ATP binding site [chemical binding]; other site
648757004337	Mg2+ binding site [ion binding]; other site
648757004338	G-X-G motif; other site
648757004339	Transcriptional regulator [Transcription]; Region: LysR; COG0583
648757004340	Helix-turn-helix domains; Region: HTH; cl00088
648757004341	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
648757004342	dimerization interface [polypeptide binding]; other site
648757004343	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
648757004344	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
648757004345	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
648757004346	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757004347	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
648757004348	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757004349	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
648757004350	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
648757004351	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757004352	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
648757004353	Fe-S cluster binding site [ion binding]; other site
648757004354	active site
648757004355	calcium/sodium:proton antiporter; Provisional; Region: PRK10599
648757004356	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
648757004357	Phospholipid methyltransferase; Region: PEMT; cl00763
648757004358	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
648757004359	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
648757004360	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757004361	MoxR-like ATPases [General function prediction only]; Region: COG0714
648757004362	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
648757004363	FOG: CBS domain [General function prediction only]; Region: COG0517
648757004364	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
648757004365	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
648757004366	S-adenosylmethionine binding site [chemical binding]; other site
648757004367	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
648757004368	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
648757004369	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
648757004370	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
648757004371	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
648757004372	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
648757004373	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
648757004374	putative dimer interface [polypeptide binding]; other site
648757004375	N-terminal domain interface [polypeptide binding]; other site
648757004376	putative substrate binding pocket (H-site) [chemical binding]; other site
648757004377	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
648757004378	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
648757004379	RNA binding surface [nucleotide binding]; other site
648757004380	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
648757004381	active site
648757004382	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
648757004383	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
648757004384	motif I; other site
648757004385	active site
648757004386	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
648757004387	motif II; other site
648757004388	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
648757004389	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
648757004390	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
648757004391	Protein of unknown function (DUF2023); Region: DUF2023; pfam09633
648757004392	Transcriptional regulator [Transcription]; Region: LysR; COG0583
648757004393	Helix-turn-helix domains; Region: HTH; cl00088
648757004394	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
648757004395	dimerization interface [polypeptide binding]; other site
648757004396	Domain of unknown function (DUF1127); Region: DUF1127; cl02276
648757004397	putative cation:proton antiport protein; Provisional; Region: PRK10669
648757004398	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
648757004399	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757004400	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
648757004401	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
648757004402	active site
648757004403	dimerization interface [polypeptide binding]; other site
648757004404	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
648757004405	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
648757004406	FeS/SAM binding site; other site
648757004407	HemN C-terminal domain; Region: HemN_C; pfam06969
648757004408	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
648757004409	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
648757004410	putative ligand binding site [chemical binding]; other site
648757004411	Predicted methyltransferases [General function prediction only]; Region: COG0313
648757004412	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
648757004413	Restriction endonuclease; Region: Mrr_cat; cl00516
648757004414	glutathione synthetase; Provisional; Region: PRK05246
648757004415	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
648757004416	ATP-grasp domain; Region: ATP-grasp_4; cl03087
648757004417	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
648757004418	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
648757004419	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
648757004420	Fic/DOC family; Region: Fic; cl00960
648757004421	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
648757004422	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
648757004423	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
648757004424	active site
648757004425	dimer interface [polypeptide binding]; other site
648757004426	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
648757004427	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
648757004428	active site
648757004429	FMN binding site [chemical binding]; other site
648757004430	substrate binding site [chemical binding]; other site
648757004431	3Fe-4S cluster binding site [ion binding]; other site
648757004432	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
648757004433	domain interface; other site
648757004434	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
648757004435	G1 box; other site
648757004436	GTP/Mg2+ binding site [chemical binding]; other site
648757004437	G2 box; other site
648757004438	Switch I region; other site
648757004439	G3 box; other site
648757004440	Switch II region; other site
648757004441	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757004442	G1 box; other site
648757004443	GTP/Mg2+ binding site [chemical binding]; other site
648757004444	G2 box; other site
648757004445	G3 box; other site
648757004446	Switch II region; other site
648757004447	G4 box; other site
648757004448	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; cl11480
648757004449	oxidoreductase; Provisional; Region: PRK06128
648757004450	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
648757004451	NAD binding site [chemical binding]; other site
648757004452	metal binding site [ion binding]; metal-binding site
648757004453	active site
648757004454	N-formylglutamate amidohydrolase; Region: FGase; cl01522
648757004455	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
648757004456	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
648757004457	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
648757004458	ABC transporter; Region: ABC_tran_2; pfam12848
648757004459	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
648757004460	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
648757004461	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
648757004462	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
648757004463	heme binding site [chemical binding]; other site
648757004464	ferroxidase pore; other site
648757004465	ferroxidase diiron center [ion binding]; other site
648757004466	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
648757004467	active site clefts [active]
648757004468	zinc binding site [ion binding]; other site
648757004469	dimer interface [polypeptide binding]; other site
648757004470	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
648757004471	potassium uptake protein; Region: kup; TIGR00794
648757004472	K+ potassium transporter; Region: K_trans; cl15781
648757004473	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
648757004474	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757004475	NAD(P) binding site [chemical binding]; other site
648757004476	acyl-CoA synthetase; Validated; Region: PRK08162
648757004477	AMP-binding enzyme; Region: AMP-binding; cl15778
648757004478	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
648757004479	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
648757004480	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
648757004481	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
648757004482	Rhomboid family; Region: Rhomboid; cl11446
648757004483	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
648757004484	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
648757004485	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
648757004486	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
648757004487	putative dimer interface [polypeptide binding]; other site
648757004488	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
648757004489	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
648757004490	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
648757004491	active site
648757004492	dimer interface [polypeptide binding]; other site
648757004493	effector binding site; other site
648757004494	TSCPD domain; Region: TSCPD; cl14834
648757004495	acetyl-CoA synthetase; Provisional; Region: PRK00174
648757004496	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
648757004497	AMP-binding enzyme; Region: AMP-binding; cl15778
648757004498	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
648757004499	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
648757004500	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
648757004501	active site
648757004502	catalytic residues [active]
648757004503	metal binding site [ion binding]; metal-binding site
648757004504	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
648757004505	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
648757004506	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
648757004507	active site
648757004508	HIGH motif; other site
648757004509	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
648757004510	KMSKS motif; other site
648757004511	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
648757004512	Protein of unknown function (DUF2865); Region: DUF2865; pfam11064
648757004513	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
648757004514	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
648757004515	Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078
648757004516	2-isopropylmalate synthase; Validated; Region: PRK00915
648757004517	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
648757004518	active site
648757004519	catalytic residues [active]
648757004520	metal binding site [ion binding]; metal-binding site
648757004521	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
648757004522	hypothetical protein; Provisional; Region: PRK12472
648757004523	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
648757004524	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
648757004525	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
648757004526	Ligand binding site; other site
648757004527	metal-binding site
648757004528	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
648757004529	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; cl01548
648757004530	choline dehydrogenase; Validated; Region: PRK02106
648757004531	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757004532	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
648757004533	aminodeoxychorismate synthase; Provisional; Region: PRK07508
648757004534	chorismate binding enzyme; Region: Chorismate_bind; cl10555
648757004535	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224
648757004536	homodimer interface [polypeptide binding]; other site
648757004537	substrate-cofactor binding pocket; other site
648757004538	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757004539	catalytic residue [active]
648757004540	putative diguanylate cyclase; Provisional; Region: PRK09776
648757004541	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
648757004542	PAS domain S-box; Region: sensory_box; TIGR00229
648757004543	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
648757004544	putative active site [active]
648757004545	heme pocket [chemical binding]; other site
648757004546	PAS domain; Region: PAS_9; pfam13426
648757004547	GAF domain; Region: GAF_2; pfam13185
648757004548	GAF domain; Region: GAF; cl15785
648757004549	PAS domain S-box; Region: sensory_box; TIGR00229
648757004550	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
648757004551	putative active site [active]
648757004552	heme pocket [chemical binding]; other site
648757004553	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
648757004554	Histidine kinase; Region: HisKA_2; cl06527
648757004555	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
648757004556	active site
648757004557	phosphorylation site [posttranslational modification]
648757004558	intermolecular recognition site; other site
648757004559	dimerization interface [polypeptide binding]; other site
648757004560	Sporulation related domain; Region: SPOR; cl10051
648757004561	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
648757004562	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104
648757004563	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
648757004564	active site
648757004565	HIGH motif; other site
648757004566	KMSK motif region; other site
648757004567	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
648757004568	tRNA binding surface [nucleotide binding]; other site
648757004569	anticodon binding site; other site
648757004570	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
648757004571	ferrochelatase; Reviewed; Region: hemH; PRK00035
648757004572	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
648757004573	C-terminal domain interface [polypeptide binding]; other site
648757004574	active site
648757004575	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
648757004576	active site
648757004577	N-terminal domain interface [polypeptide binding]; other site
648757004578	16S rRNA methyltransferase B; Provisional; Region: PRK10901
648757004579	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
648757004580	GMP synthase; Reviewed; Region: guaA; PRK00074
648757004581	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
648757004582	AMP/PPi binding site [chemical binding]; other site
648757004583	candidate oxyanion hole; other site
648757004584	catalytic triad [active]
648757004585	potential glutamine specificity residues [chemical binding]; other site
648757004586	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
648757004587	ATP Binding subdomain [chemical binding]; other site
648757004588	Ligand Binding sites [chemical binding]; other site
648757004589	Dimerization subdomain; other site
648757004590	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
648757004591	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
648757004592	Response regulator receiver domain; Region: Response_reg; pfam00072
648757004593	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757004594	active site
648757004595	phosphorylation site [posttranslational modification]
648757004596	intermolecular recognition site; other site
648757004597	dimerization interface [polypeptide binding]; other site
648757004598	hypothetical protein; Provisional; Region: PRK01842
648757004599	SEC-C motif; Region: SEC-C; pfam02810
648757004600	RF-1 domain; Region: RF-1; cl02875
648757004601	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
648757004602	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
648757004603	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
648757004604	catalytic residue [active]
648757004605	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
648757004606	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
648757004607	putative metal binding site [ion binding]; other site
648757004608	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
648757004609	HSP70 interaction site [polypeptide binding]; other site
648757004610	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
648757004611	amidase catalytic site [active]
648757004612	Zn binding residues [ion binding]; other site
648757004613	substrate binding site [chemical binding]; other site
648757004614	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
648757004615	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
648757004616	CreA protein; Region: CreA; pfam05981
648757004617	MgtC family; Region: MgtC; pfam02308
648757004618	GcrA cell cycle regulator; Region: GcrA; cl11564
648757004619	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
648757004620	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
648757004621	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757004622	Uncharacterized conserved protein [Function unknown]; Region: COG1565
648757004623	Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636
648757004624	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
648757004625	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
648757004626	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
648757004627	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
648757004628	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
648757004629	active site
648757004630	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
648757004631	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
648757004632	5S rRNA interface [nucleotide binding]; other site
648757004633	CTC domain interface [polypeptide binding]; other site
648757004634	L16 interface [polypeptide binding]; other site
648757004635	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
648757004636	putative active site [active]
648757004637	catalytic residue [active]
648757004638	ribonuclease E; Reviewed; Region: rne; PRK10811
648757004639	GTP-binding protein YchF; Reviewed; Region: PRK09601
648757004640	YchF GTPase; Region: YchF; cd01900
648757004641	G1 box; other site
648757004642	GTP/Mg2+ binding site [chemical binding]; other site
648757004643	Switch I region; other site
648757004644	G2 box; other site
648757004645	Switch II region; other site
648757004646	G3 box; other site
648757004647	G4 box; other site
648757004648	G5 box; other site
648757004649	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
648757004650	Helix-turn-helix domains; Region: HTH; cl00088
648757004651	Winged helix-turn helix; Region: HTH_29; pfam13551
648757004652	Integrase core domain; Region: rve; cl01316
648757004653	DDE domain; Region: DDE_Tnp_IS240; pfam13610
648757004654	Integrase core domain; Region: rve_3; cl15866
648757004655	Helix-turn-helix domains; Region: HTH; cl00088
648757004656	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
648757004657	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
648757004658	active site
648757004659	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
648757004660	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
648757004661	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
648757004662	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
648757004663	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757004664	CoA-ligase; Region: Ligase_CoA; cl02894
648757004665	ATP-grasp domain; Region: ATP-grasp_4; cl03087
648757004666	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
648757004667	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
648757004668	Uncharacterized ACR, COG1678; Region: DUF179; cl00731
648757004669	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
648757004670	Predicted kinase [General function prediction only]; Region: COG0645
648757004671	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
648757004672	ATP-binding site [chemical binding]; other site
648757004673	Gluconate-6-phosphate binding site [chemical binding]; other site
648757004674	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
648757004675	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
648757004676	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611
648757004677	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
648757004678	UbiA prenyltransferase family; Region: UbiA; cl00337
648757004679	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638
648757004680	active site
648757004681	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
648757004682	putative acyl-acceptor binding pocket; other site
648757004683	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
648757004684	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
648757004685	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652
648757004686	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652
648757004687	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
648757004688	Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043
648757004689	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
648757004690	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
648757004691	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560
648757004692	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757004693	catalytic residue [active]
648757004694	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
648757004695	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
648757004696	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
648757004697	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
648757004698	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
648757004699	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
648757004700	PAS fold; Region: PAS_3; pfam08447
648757004701	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
648757004702	metal binding site [ion binding]; metal-binding site
648757004703	active site
648757004704	I-site; other site
648757004705	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
648757004706	TMAO/DMSO reductase; Reviewed; Region: PRK05363
648757004707	YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107
648757004708	Moco binding site; other site
648757004709	metal coordination site [ion binding]; other site
648757004710	Predicted permeases [General function prediction only]; Region: RarD; COG2962
648757004711	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
648757004712	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
648757004713	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
648757004714	FMN binding site [chemical binding]; other site
648757004715	active site
648757004716	catalytic residues [active]
648757004717	substrate binding site [chemical binding]; other site
648757004718	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
648757004719	DNA binding site [nucleotide binding]
648757004720	Int/Topo IB signature motif; other site
648757004721	active site
648757004722	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
648757004723	trimer interface [polypeptide binding]; other site
648757004724	putative metal binding site [ion binding]; other site
648757004725	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
648757004726	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
648757004727	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
648757004728	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
648757004729	VirB7 interaction site; other site
648757004730	VirB8 protein; Region: VirB8; cl01500
648757004731	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
648757004732	Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314; cl02193
648757004733	conjugal transfer protein TrbE; Provisional; Region: PRK13891
648757004734	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
648757004735	Domain of unknown function DUF87; Region: DUF87; pfam01935
648757004736	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757004737	Walker B; other site
648757004738	D-loop; other site
648757004739	H-loop/switch region; other site
648757004740	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
648757004741	TrbC/VIRB2 family; Region: TrbC; cl01583
648757004742	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
648757004743	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
648757004744	ATP binding site [chemical binding]; other site
648757004745	Walker A motif; other site
648757004746	hexamer interface [polypeptide binding]; other site
648757004747	Walker B motif; other site
648757004748	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
648757004749	non-specific DNA binding site [nucleotide binding]; other site
648757004750	salt bridge; other site
648757004751	sequence-specific DNA binding site [nucleotide binding]; other site
648757004752	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
648757004753	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
648757004754	Integrase core domain; Region: rve; cl01316
648757004755	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
648757004756	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
648757004757	Helix-turn-helix domains; Region: HTH; cl00088
648757004758	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
648757004759	conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877
648757004760	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757004761	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
648757004762	DNA binding site [nucleotide binding]
648757004763	Int/Topo IB signature motif; other site
648757004764	active site
648757004765	Helix-turn-helix domains; Region: HTH; cl00088
648757004766	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
648757004767	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757004768	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
648757004769	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
648757004770	Catalytic dyad [active]
648757004771	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
648757004772	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
648757004773	Integrase core domain; Region: rve; cl01316
648757004774	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
648757004775	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
648757004776	Helix-turn-helix domains; Region: HTH; cl00088
648757004777	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
648757004778	non-specific DNA binding site [nucleotide binding]; other site
648757004779	salt bridge; other site
648757004780	sequence-specific DNA binding site [nucleotide binding]; other site
648757004781	Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112
648757004782	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
648757004783	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973
648757004784	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
648757004785	spermidine synthase; Provisional; Region: PRK03612
648757004786	Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262
648757004787	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
648757004788	PPIC-type PPIASE domain; Region: Rotamase; cl08278
648757004789	HupE / UreJ protein; Region: HupE_UreJ; cl01011
648757004790	HupE / UreJ protein; Region: HupE_UreJ; cl01011
648757004791	HupE / UreJ protein; Region: HupE_UreJ; cl01011
648757004792	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
648757004793	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
648757004794	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
648757004795	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
648757004796	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
648757004797	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
648757004798	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
648757004799	Walker A motif; other site
648757004800	ATP binding site [chemical binding]; other site
648757004801	Walker B motif; other site
648757004802	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
648757004803	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
648757004804	fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310
648757004805	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
648757004806	Secretin and TonB N terminus short domain; Region: STN; cl06624
648757004807	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
648757004808	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
648757004809	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
648757004810	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
648757004811	Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277
648757004812	dimer interface [polypeptide binding]; other site
648757004813	Trp docking motif [polypeptide binding]; other site
648757004814	active site
648757004815	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
648757004816	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
648757004817	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
648757004818	Cytochrome c; Region: Cytochrom_C; cl11414
648757004819	Cytochrome c; Region: Cytochrom_C; cl11414
648757004820	Cytochrome c; Region: Cytochrom_C; cl11414
648757004821	Cache domain; Region: Cache_2; cl07034
648757004822	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
648757004823	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
648757004824	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
648757004825	NAD(P) binding site [chemical binding]; other site
648757004826	catalytic residues [active]
648757004827	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
648757004828	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757004829	Family description; Region: UvrD_C_2; cl15862
648757004830	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
648757004831	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
648757004832	THF binding site; other site
648757004833	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
648757004834	substrate binding site [chemical binding]; other site
648757004835	THF binding site; other site
648757004836	zinc-binding site [ion binding]; other site
648757004837	PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513
648757004838	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
648757004839	tetramer interface [polypeptide binding]; other site
648757004840	active site
648757004841	Mg2+/Mn2+ binding site [ion binding]; other site
648757004842	Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117
648757004843	dimer interface [polypeptide binding]; other site
648757004844	Citrate synthase; Region: Citrate_synt; pfam00285
648757004845	active site
648757004846	citrylCoA binding site [chemical binding]; other site
648757004847	oxalacetate/citrate binding site [chemical binding]; other site
648757004848	coenzyme A binding site [chemical binding]; other site
648757004849	catalytic triad [active]
648757004850	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
648757004851	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
648757004852	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
648757004853	ATP cone domain; Region: ATP-cone; pfam03477
648757004854	Class III ribonucleotide reductase; Region: RNR_III; cd01675
648757004855	effector binding site; other site
648757004856	active site
648757004857	Zn binding site [ion binding]; other site
648757004858	Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597
648757004859	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
648757004860	FeS/SAM binding site; other site
648757004861	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
648757004862	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
648757004863	non-specific DNA binding site [nucleotide binding]; other site
648757004864	salt bridge; other site
648757004865	sequence-specific DNA binding site [nucleotide binding]; other site
648757004866	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
648757004867	Domain of unknown function (DUF955); Region: DUF955; cl01076
648757004868	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
648757004869	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
648757004870	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
648757004871	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
648757004872	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
648757004873	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757004874	CoA-ligase; Region: Ligase_CoA; cl02894
648757004875	ATP-grasp domain; Region: ATP-grasp_4; cl03087
648757004876	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
648757004877	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
648757004878	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
648757004879	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
648757004880	Walker A/P-loop; other site
648757004881	ATP binding site [chemical binding]; other site
648757004882	Q-loop/lid; other site
648757004883	ABC transporter signature motif; other site
648757004884	Walker B; other site
648757004885	D-loop; other site
648757004886	H-loop/switch region; other site
648757004887	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
648757004888	TM-ABC transporter signature motif; other site
648757004889	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
648757004890	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
648757004891	Walker A/P-loop; other site
648757004892	ATP binding site [chemical binding]; other site
648757004893	Q-loop/lid; other site
648757004894	ABC transporter signature motif; other site
648757004895	Walker B; other site
648757004896	D-loop; other site
648757004897	H-loop/switch region; other site
648757004898	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
648757004899	TM-ABC transporter signature motif; other site
648757004900	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
648757004901	Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360
648757004902	putative ligand binding site [chemical binding]; other site
648757004903	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
648757004904	eyelet of channel; other site
648757004905	trimer interface [polypeptide binding]; other site
648757004906	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
648757004907	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
648757004908	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
648757004909	FAD binding site [chemical binding]; other site
648757004910	substrate binding pocket [chemical binding]; other site
648757004911	catalytic base [active]
648757004912	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
648757004913	lytic murein transglycosylase; Region: MltB_2; TIGR02283
648757004914	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
648757004915	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
648757004916	dimer interface [polypeptide binding]; other site
648757004917	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757004918	catalytic residue [active]
648757004919	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
648757004920	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
648757004921	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
648757004922	homodimer interface [polypeptide binding]; other site
648757004923	substrate-cofactor binding pocket; other site
648757004924	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757004925	catalytic residue [active]
648757004926	Membrane fusogenic activity; Region: BMFP; cl01115
648757004927	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
648757004928	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757004929	Protein of unknown function (DUF461); Region: DUF461; cl01071
648757004930	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
648757004931	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
648757004932	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
648757004933	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
648757004934	AsmA-like C-terminal region; Region: AsmA_2; cl15864
648757004935	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
648757004936	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
648757004937	P-loop; other site
648757004938	Magnesium ion binding site [ion binding]; other site
648757004939	HicB family; Region: HicB; pfam05534
648757004940	Zeta toxin; Region: Zeta_toxin; pfam06414
648757004941	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
648757004942	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
648757004943	putative active site [active]
648757004944	putative NTP binding site [chemical binding]; other site
648757004945	putative nucleic acid binding site [nucleotide binding]; other site
648757004946	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
648757004947	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
648757004948	CRISPR-associated protein; Region: TIGR03986
648757004949	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592
648757004950	CRISPR-associated protein, TIGR03984 family; Region: TIGR03984
648757004951	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
648757004952	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592
648757004953	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
648757004954	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592
648757004955	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853
648757004956	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl01634
648757004957	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09741
648757004958	CRISPR/Cas system-associated protein Csx16; Region: Csx16_III-U; cd09743
648757004959	Protein of unknown function (DUF497); Region: DUF497; cl01108
648757004960	Domain of unknown function (DUF4415); Region: DUF4415; cl01401
648757004961	conjugal transfer relaxase TraI; Provisional; Region: PRK13878
648757004962	Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584
648757004963	Protein of unknown function DUF262; Region: DUF262; cl14890
648757004964	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
648757004965	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757004966	Walker A/P-loop; other site
648757004967	ATP binding site [chemical binding]; other site
648757004968	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757004969	Q-loop/lid; other site
648757004970	ABC transporter signature motif; other site
648757004971	SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279
648757004972	ABC transporter signature motif; other site
648757004973	Walker B; other site
648757004974	D-loop; other site
648757004975	H-loop/switch region; other site
648757004976	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
648757004977	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
648757004978	active site
648757004979	metal binding site [ion binding]; metal-binding site
648757004980	DNA binding site [nucleotide binding]
648757004981	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
648757004982	WYL domain; Region: WYL; cl14852
648757004983	Helix-turn-helix domains; Region: HTH; cl00088
648757004984	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
648757004985	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
648757004986	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
648757004987	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
648757004988	Integrase core domain; Region: rve; cl01316
648757004989	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
648757004990	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
648757004991	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
648757004992	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
648757004993	ATP binding site [chemical binding]; other site
648757004994	putative Mg++ binding site [ion binding]; other site
648757004995	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
648757004996	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
648757004997	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
648757004998	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
648757004999	HsdM N-terminal domain; Region: HsdM_N; pfam12161
648757005000	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757005001	Helix-turn-helix domains; Region: HTH; cl00088
648757005002	Winged helix-turn helix; Region: HTH_29; pfam13551
648757005003	Helix-turn-helix domains; Region: HTH; cl00088
648757005004	Integrase core domain; Region: rve; cl01316
648757005005	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
648757005006	Int/Topo IB signature motif; other site
648757005007	active site
648757005008	DNA binding site [nucleotide binding]
648757005009	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
648757005010	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
648757005011	RNA binding surface [nucleotide binding]; other site
648757005012	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
648757005013	active site
648757005014	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
648757005015	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
648757005016	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
648757005017	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
648757005018	DNA binding residues [nucleotide binding]
648757005019	malate synthase A; Region: malate_syn_A; TIGR01344
648757005020	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
648757005021	active site
648757005022	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
648757005023	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
648757005024	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
648757005025	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
648757005026	Coenzyme A binding pocket [chemical binding]; other site
648757005027	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
648757005028	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
648757005029	NADP binding site [chemical binding]; other site
648757005030	dimer interface [polypeptide binding]; other site
648757005031	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
648757005032	ScpA/B protein; Region: ScpA_ScpB; cl00598
648757005033	Ceramidase; Region: Ceramidase; pfam05875
648757005034	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757005035	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
648757005036	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
648757005037	HSP70 interaction site [polypeptide binding]; other site
648757005038	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
648757005039	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
648757005040	Clp amino terminal domain; Region: Clp_N; pfam02861
648757005041	Zinc-finger domain; Region: zf-CHCC; cl01821
648757005042	salicylate hydroxylase; Provisional; Region: PRK08163
648757005043	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757005044	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
648757005045	MatE; Region: MatE; cl10513
648757005046	MatE; Region: MatE; cl10513
648757005047	chaperone protein DnaJ; Provisional; Region: PRK14299
648757005048	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
648757005049	HSP70 interaction site [polypeptide binding]; other site
648757005050	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
648757005051	substrate binding site [polypeptide binding]; other site
648757005052	dimer interface [polypeptide binding]; other site
648757005053	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
648757005054	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
648757005055	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
648757005056	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
648757005057	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
648757005058	FeS/SAM binding site; other site
648757005059	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
648757005060	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
648757005061	G1 box; other site
648757005062	putative GEF interaction site [polypeptide binding]; other site
648757005063	GTP/Mg2+ binding site [chemical binding]; other site
648757005064	Switch I region; other site
648757005065	G2 box; other site
648757005066	G3 box; other site
648757005067	Switch II region; other site
648757005068	G4 box; other site
648757005069	G5 box; other site
648757005070	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
648757005071	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
648757005072	Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033
648757005073	putative catalytic residues [active]
648757005074	selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309
648757005075	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
648757005076	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
648757005077	heme-binding site [chemical binding]; other site
648757005078	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
648757005079	active site
648757005080	phosphorylation site [posttranslational modification]
648757005081	intermolecular recognition site; other site
648757005082	dimerization interface [polypeptide binding]; other site
648757005083	nitrogenase reductase; Reviewed; Region: nifH; PRK13234
648757005084	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
648757005085	Nucleotide-binding sites [chemical binding]; other site
648757005086	Walker A motif; other site
648757005087	Switch I region of nucleotide binding site; other site
648757005088	Fe4S4 binding sites [ion binding]; other site
648757005089	Switch II region of nucleotide binding site; other site
648757005090	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
648757005091	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
648757005092	MoFe protein alpha/beta subunit interactions; other site
648757005093	Alpha subunit P cluster binding residues; other site
648757005094	FeMoco binding residues [chemical binding]; other site
648757005095	MoFe protein alpha subunit/Fe protein contacts; other site
648757005096	MoFe protein dimer/ dimer interactions; other site
648757005097	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
648757005098	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
648757005099	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
648757005100	MoFe protein beta/alpha subunit interactions; other site
648757005101	Beta subunit P cluster binding residues; other site
648757005102	MoFe protein beta subunit/Fe protein contacts; other site
648757005103	MoFe protein dimer/ dimer interactions; other site
648757005104	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
648757005105	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
648757005106	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
648757005107	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
648757005108	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
648757005109	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
648757005110	Protein of unknown function, DUF269; Region: DUF269; cl03973
648757005111	Rop-like; Region: Rop-like; cl02247
648757005112	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
648757005113	NifQ; Region: NifQ; pfam04891
648757005114	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
648757005115	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757005116	Rhomboid family; Region: Rhomboid; cl11446
648757005117	Ribbon-helix-helix domain; Region: RHH_4; cl01775
648757005118	fumarate hydratase; Reviewed; Region: fumC; PRK00485
648757005119	Class II fumarases; Region: Fumarase_classII; cd01362
648757005120	active site
648757005121	tetramer interface [polypeptide binding]; other site
648757005122	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
648757005123	putative active site pocket [active]
648757005124	dimerization interface [polypeptide binding]; other site
648757005125	putative catalytic residue [active]
648757005126	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
648757005127	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
648757005128	NAD(P) binding site [chemical binding]; other site
648757005129	Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232
648757005130	dimer interface [polypeptide binding]; other site
648757005131	catalytic residue [active]
648757005132	metal binding site [ion binding]; metal-binding site
648757005133	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
648757005134	SOUL heme-binding protein; Region: SOUL; pfam04832
648757005135	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
648757005136	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
648757005137	TPP-binding site; other site
648757005138	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
648757005139	PYR/PP interface [polypeptide binding]; other site
648757005140	dimer interface [polypeptide binding]; other site
648757005141	TPP binding site [chemical binding]; other site
648757005142	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
648757005143	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
648757005144	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
648757005145	Histone deacetylase domain; Region: Hist_deacetyl; cl02986
648757005146	short chain dehydrogenase; Provisional; Region: PRK08278
648757005147	human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762
648757005148	NAD(P) binding site [chemical binding]; other site
648757005149	homodimer interface [polypeptide binding]; other site
648757005150	active site
648757005151	enoyl-CoA hydratase; Provisional; Region: PRK06688
648757005152	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
648757005153	substrate binding site [chemical binding]; other site
648757005154	oxyanion hole (OAH) forming residues; other site
648757005155	trimer interface [polypeptide binding]; other site
648757005156	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
648757005157	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
648757005158	active site
648757005159	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
648757005160	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
648757005161	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687
648757005162	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
648757005163	putative active site [active]
648757005164	putative catalytic site [active]
648757005165	spermidine synthase; Provisional; Region: PRK00811
648757005166	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
648757005167	S-adenosylmethionine binding site [chemical binding]; other site
648757005168	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
648757005169	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
648757005170	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
648757005171	generic binding surface II; other site
648757005172	generic binding surface I; other site
648757005173	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
648757005174	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
648757005175	ATP-grasp domain; Region: ATP-grasp_4; cl03087
648757005176	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
648757005177	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
648757005178	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
648757005179	dimerization interface [polypeptide binding]; other site
648757005180	metal binding site [ion binding]; metal-binding site
648757005181	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
648757005182	active site
648757005183	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
648757005184	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
648757005185	substrate binding site [chemical binding]; other site
648757005186	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
648757005187	substrate binding site [chemical binding]; other site
648757005188	ligand binding site [chemical binding]; other site
648757005189	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
648757005190	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
648757005191	NifU-like domain; Region: NifU; cl00484
648757005192	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
648757005193	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
648757005194	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
648757005195	catalytic residue [active]
648757005196	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
648757005197	metal binding site 2 [ion binding]; metal-binding site
648757005198	putative DNA binding helix; other site
648757005199	metal binding site 1 [ion binding]; metal-binding site
648757005200	dimer interface [polypeptide binding]; other site
648757005201	structural Zn2+ binding site [ion binding]; other site
648757005202	30S ribosomal protein S2/unknown domain fusion protein; Provisional; Region: rpsB; PRK12311
648757005203	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
648757005204	rRNA interaction site [nucleotide binding]; other site
648757005205	S8 interaction site; other site
648757005206	putative laminin-1 binding site; other site
648757005207	Uncharacterized conserved protein [Function unknown]; Region: COG3743
648757005208	elongation factor Ts; Provisional; Region: tsf; PRK09377
648757005209	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
648757005210	Elongation factor TS; Region: EF_TS; pfam00889
648757005211	Elongation factor TS; Region: EF_TS; pfam00889
648757005212	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
648757005213	putative nucleotide binding site [chemical binding]; other site
648757005214	uridine monophosphate binding site [chemical binding]; other site
648757005215	homohexameric interface [polypeptide binding]; other site
648757005216	ribosome recycling factor; Reviewed; Region: frr; PRK00083
648757005217	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
648757005218	hinge region; other site
648757005219	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
648757005220	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
648757005221	catalytic residue [active]
648757005222	putative FPP diphosphate  binding site; other site
648757005223	putative FPP binding hydrophobic cleft; other site
648757005224	dimer interface [polypeptide binding]; other site
648757005225	putative IPP diphosphate binding site; other site
648757005226	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
648757005227	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
648757005228	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
648757005229	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
648757005230	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
648757005231	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
648757005232	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
648757005233	active site
648757005234	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
648757005235	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
648757005236	putative substrate binding region [chemical binding]; other site
648757005237	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
648757005238	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
648757005239	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
648757005240	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
648757005241	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
648757005242	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
648757005243	Surface antigen; Region: Bac_surface_Ag; cl03097
648757005244	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
648757005245	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
648757005246	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
648757005247	trimer interface [polypeptide binding]; other site
648757005248	active site
648757005249	UDP-GlcNAc binding site [chemical binding]; other site
648757005250	lipid binding site [chemical binding]; lipid-binding site
648757005251	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
648757005252	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
648757005253	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
648757005254	active site
648757005255	Protein of unknown function (DUF1009); Region: DUF1009; cl09182
648757005256	Protein of unknown function (DUF423); Region: DUF423; cl01008
648757005257	Short C-terminal domain; Region: SHOCT; cl01373
648757005258	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
648757005259	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
648757005260	Walker A motif; other site
648757005261	ATP binding site [chemical binding]; other site
648757005262	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757005263	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
648757005264	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
648757005265	active site
648757005266	HslU subunit interaction site [polypeptide binding]; other site
648757005267	imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951
648757005268	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
648757005269	putative active site pocket [active]
648757005270	4-fold oligomerization interface [polypeptide binding]; other site
648757005271	metal binding residues [ion binding]; metal-binding site
648757005272	3-fold/trimer interface [polypeptide binding]; other site
648757005273	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
648757005274	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
648757005275	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
648757005276	putative active site [active]
648757005277	oxyanion strand; other site
648757005278	catalytic triad [active]
648757005279	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106
648757005280	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
648757005281	catalytic residues [active]
648757005282	hypothetical protein; Reviewed; Region: PRK11901
648757005283	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
648757005284	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757005285	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
648757005286	Superfamily II helicase [General function prediction only]; Region: COG1204
648757005287	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
648757005288	nucleotide binding region [chemical binding]; other site
648757005289	ATP-binding site [chemical binding]; other site
648757005290	transcription termination factor Rho; Provisional; Region: PRK12678
648757005291	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
648757005292	RNA binding surface [nucleotide binding]; other site
648757005293	recombination factor protein RarA; Reviewed; Region: PRK13342
648757005294	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
648757005295	Walker A motif; other site
648757005296	ATP binding site [chemical binding]; other site
648757005297	Walker B motif; other site
648757005298	arginine finger; other site
648757005299	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
648757005300	methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841
648757005301	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
648757005302	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
648757005303	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
648757005304	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
648757005305	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
648757005306	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
648757005307	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
648757005308	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
648757005309	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
648757005310	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
648757005311	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
648757005312	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
648757005313	Protein export membrane protein; Region: SecD_SecF; cl14618
648757005314	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
648757005315	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
648757005316	integrase; Provisional; Region: PRK09692
648757005317	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
648757005318	active site
648757005319	Int/Topo IB signature motif; other site
648757005320	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
648757005321	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
648757005322	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
648757005323	active site
648757005324	metal binding site [ion binding]; metal-binding site
648757005325	interdomain interaction site; other site
648757005326	Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022
648757005327	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
648757005328	tandem repeat interface [polypeptide binding]; other site
648757005329	oligomer interface [polypeptide binding]; other site
648757005330	active site residues [active]
648757005331	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
648757005332	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
648757005333	Integrase core domain; Region: rve; cl01316
648757005334	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
648757005335	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
648757005336	Helix-turn-helix domains; Region: HTH; cl00088
648757005337	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
648757005338	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757005339	Walker A/P-loop; other site
648757005340	ATP binding site [chemical binding]; other site
648757005341	Restriction endonuclease; Region: Mrr_cat; cl00516
648757005342	Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987
648757005343	Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452
648757005344	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
648757005345	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
648757005346	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
648757005347	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
648757005348	FixH; Region: FixH; cl01254
648757005349	Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; cl08082
648757005350	TolB amino-terminal domain; Region: TolB_N; cl00639
648757005351	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
648757005352	Thin aggregative fimbriae synthesis protein; Region: Tafi-CsgC; cl11667
648757005353	Transposase domain (DUF772); Region: DUF772; cl15789
648757005354	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
648757005355	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
648757005356	Walker A/P-loop; other site
648757005357	ATP binding site [chemical binding]; other site
648757005358	Q-loop/lid; other site
648757005359	ABC transporter signature motif; other site
648757005360	Walker B; other site
648757005361	D-loop; other site
648757005362	H-loop/switch region; other site
648757005363	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
648757005364	dimer interface [polypeptide binding]; other site
648757005365	conserved gate region; other site
648757005366	putative PBP binding loops; other site
648757005367	ABC-ATPase subunit interface; other site
648757005368	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
648757005369	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
648757005370	substrate binding pocket [chemical binding]; other site
648757005371	membrane-bound complex binding site; other site
648757005372	hinge residues; other site
648757005373	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
648757005374	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
648757005375	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
648757005376	catalytic residue [active]
648757005377	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
648757005378	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
648757005379	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
648757005380	FeS/SAM binding site; other site
648757005381	radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043
648757005382	Biotin synthase and related enzymes [Coenzyme metabolism]; Region: BioB; COG0502
648757005383	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
648757005384	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
648757005385	ligand binding site [chemical binding]; other site
648757005386	flexible hinge region; other site
648757005387	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
648757005388	putative switch regulator; other site
648757005389	non-specific DNA interactions [nucleotide binding]; other site
648757005390	DNA binding site [nucleotide binding]
648757005391	sequence specific DNA binding site [nucleotide binding]; other site
648757005392	putative cAMP binding site [chemical binding]; other site
648757005393	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
648757005394	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
648757005395	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
648757005396	inhibitor-cofactor binding pocket; inhibition site
648757005397	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757005398	catalytic residue [active]
648757005399	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
648757005400	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
648757005401	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
648757005402	homodimer interface [polypeptide binding]; other site
648757005403	substrate-cofactor binding pocket; other site
648757005404	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757005405	catalytic residue [active]
648757005406	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
648757005407	classical (c) SDR, subgroup  10; Region: SDR_c10; cd05373
648757005408	putative NAD(P) binding site [chemical binding]; other site
648757005409	active site
648757005410	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757005411	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
648757005412	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
648757005413	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
648757005414	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
648757005415	Walker A motif; other site
648757005416	ATP binding site [chemical binding]; other site
648757005417	Walker B motif; other site
648757005418	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
648757005419	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
648757005420	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
648757005421	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
648757005422	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
648757005423	ATP binding site [chemical binding]; other site
648757005424	putative Mg++ binding site [ion binding]; other site
648757005425	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
648757005426	nucleotide binding region [chemical binding]; other site
648757005427	ATP-binding site [chemical binding]; other site
648757005428	DEAD/H associated; Region: DEAD_assoc; pfam08494
648757005429	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
648757005430	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
648757005431	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
648757005432	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
648757005433	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
648757005434	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
648757005435	motif II; other site
648757005436	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
648757005437	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
648757005438	nucleotide binding pocket [chemical binding]; other site
648757005439	K-X-D-G motif; other site
648757005440	catalytic site [active]
648757005441	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
648757005442	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
648757005443	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
648757005444	Dimer interface [polypeptide binding]; other site
648757005445	BRCT sequence motif; other site
648757005446	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
648757005447	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
648757005448	Walker A/P-loop; other site
648757005449	ATP binding site [chemical binding]; other site
648757005450	Q-loop/lid; other site
648757005451	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
648757005452	ABC transporter signature motif; other site
648757005453	Walker B; other site
648757005454	D-loop; other site
648757005455	H-loop/switch region; other site
648757005456	hypothetical protein; Provisional; Region: PRK11469
648757005457	Domain of unknown function DUF; Region: DUF204; pfam02659
648757005458	Domain of unknown function DUF; Region: DUF204; pfam02659
648757005459	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
648757005460	UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512
648757005461	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
648757005462	cell division protein FtsZ; Validated; Region: PRK09330
648757005463	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
648757005464	nucleotide binding site [chemical binding]; other site
648757005465	SulA interaction site; other site
648757005466	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
648757005467	Cell division protein FtsA; Region: FtsA; cl11496
648757005468	Cell division protein FtsA; Region: FtsA; cl11496
648757005469	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
648757005470	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
648757005471	Cell division protein FtsQ; Region: FtsQ; pfam03799
648757005472	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
648757005473	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
648757005474	ATP-grasp domain; Region: ATP-grasp_4; cl03087
648757005475	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
648757005476	FAD binding domain; Region: FAD_binding_4; pfam01565
648757005477	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
648757005478	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
648757005479	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
648757005480	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
648757005481	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
648757005482	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
648757005483	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
648757005484	active site
648757005485	homodimer interface [polypeptide binding]; other site
648757005486	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
648757005487	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
648757005488	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
648757005489	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
648757005490	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
648757005491	Mg++ binding site [ion binding]; other site
648757005492	putative catalytic motif [active]
648757005493	putative substrate binding site [chemical binding]; other site
648757005494	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
648757005495	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
648757005496	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
648757005497	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
648757005498	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
648757005499	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
648757005500	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
648757005501	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
648757005502	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
648757005503	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
648757005504	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
648757005505	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
648757005506	B12 binding site [chemical binding]; other site
648757005507	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
648757005508	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
648757005509	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
648757005510	Radical SAM superfamily; Region: Radical_SAM; pfam04055
648757005511	FeS/SAM binding site; other site
648757005512	MarC family integral membrane protein; Region: MarC; cl00919
648757005513	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
648757005514	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
648757005515	FeS/SAM binding site; other site
648757005516	nitrobindin heme-binding domain; Region: nitrobindin; cl10502
648757005517	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
648757005518	dimer interface [polypeptide binding]; other site
648757005519	substrate binding site [chemical binding]; other site
648757005520	ATP binding site [chemical binding]; other site
648757005521	Cytochrome c [Energy production and conversion]; Region: COG3258
648757005522	phosphoglycolate phosphatase; Provisional; Region: PRK13222
648757005523	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
648757005524	motif II; other site
648757005525	hypothetical protein; Provisional; Region: PRK08185
648757005526	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
648757005527	intersubunit interface [polypeptide binding]; other site
648757005528	active site
648757005529	zinc binding site [ion binding]; other site
648757005530	Na+ binding site [ion binding]; other site
648757005531	Phosphoglycerate kinase; Region: PGK; pfam00162
648757005532	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
648757005533	substrate binding site [chemical binding]; other site
648757005534	hinge regions; other site
648757005535	ADP binding site [chemical binding]; other site
648757005536	catalytic site [active]
648757005537	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757005538	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
648757005539	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
648757005540	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
648757005541	putative active site [active]
648757005542	putative metal binding site [ion binding]; other site
648757005543	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
648757005544	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
648757005545	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
648757005546	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
648757005547	tetramer interface [polypeptide binding]; other site
648757005548	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757005549	catalytic residue [active]
648757005550	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
648757005551	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
648757005552	putative active site [active]
648757005553	putative metal binding site [ion binding]; other site
648757005554	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
648757005555	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
648757005556	active site
648757005557	Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962
648757005558	NodB motif; other site
648757005559	putative active site [active]
648757005560	putative catalytic site [active]
648757005561	putative Zn binding site [ion binding]; other site
648757005562	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
648757005563	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
648757005564	DXD motif; other site
648757005565	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
648757005566	putative active site [active]
648757005567	Protein of unknown function DUF72; Region: DUF72; cl00777
648757005568	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
648757005569	Predicted transcriptional regulator [Transcription]; Region: COG4957
648757005570	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
648757005571	DEAD-like helicases superfamily; Region: DEXDc; smart00487
648757005572	ATP binding site [chemical binding]; other site
648757005573	Mg++ binding site [ion binding]; other site
648757005574	motif III; other site
648757005575	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
648757005576	nucleotide binding region [chemical binding]; other site
648757005577	ATP-binding site [chemical binding]; other site
648757005578	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
648757005579	Transcriptional regulator [Transcription]; Region: LysR; COG0583
648757005580	Helix-turn-helix domains; Region: HTH; cl00088
648757005581	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
648757005582	putative effector binding pocket; other site
648757005583	dimerization interface [polypeptide binding]; other site
648757005584	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
648757005585	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
648757005586	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
648757005587	Helix-turn-helix domains; Region: HTH; cl00088
648757005588	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
648757005589	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
648757005590	Uncharacterized protein conserved in bacteria (DUF2084); Region: DUF2084; cl01566
648757005591	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
648757005592	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757005593	G1 box; other site
648757005594	GTP/Mg2+ binding site [chemical binding]; other site
648757005595	G2 box; other site
648757005596	Switch I region; other site
648757005597	G3 box; other site
648757005598	Switch II region; other site
648757005599	G4 box; other site
648757005600	G5 box; other site
648757005601	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
648757005602	Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G.  Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786
648757005603	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
648757005604	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
648757005605	Active Sites [active]
648757005606	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
648757005607	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
648757005608	Active Sites [active]
648757005609	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
648757005610	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
648757005611	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
648757005612	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
648757005613	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
648757005614	ATP-grasp domain; Region: ATP-grasp_4; cl03087
648757005615	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
648757005616	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
648757005617	ATP-grasp domain; Region: ATP-grasp_4; cl03087
648757005618	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
648757005619	IMP binding site; other site
648757005620	dimer interface [polypeptide binding]; other site
648757005621	interdomain contacts; other site
648757005622	partial ornithine binding site; other site
648757005623	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
648757005624	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
648757005625	heterodimer interface [polypeptide binding]; other site
648757005626	substrate interaction site [chemical binding]; other site
648757005627	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
648757005628	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
648757005629	active site
648757005630	substrate binding site [chemical binding]; other site
648757005631	coenzyme B12 binding site [chemical binding]; other site
648757005632	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
648757005633	B12 binding site [chemical binding]; other site
648757005634	cobalt ligand [ion binding]; other site
648757005635	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
648757005636	oligomerization interface [polypeptide binding]; other site
648757005637	active site
648757005638	metal binding site [ion binding]; metal-binding site
648757005639	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
648757005640	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
648757005641	Trp docking motif [polypeptide binding]; other site
648757005642	active site
648757005643	PQQ-like domain; Region: PQQ_2; pfam13360
648757005644	GTP-binding protein Der; Reviewed; Region: PRK00093
648757005645	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
648757005646	G1 box; other site
648757005647	GTP/Mg2+ binding site [chemical binding]; other site
648757005648	Switch I region; other site
648757005649	G2 box; other site
648757005650	Switch II region; other site
648757005651	G3 box; other site
648757005652	G4 box; other site
648757005653	G5 box; other site
648757005654	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
648757005655	G1 box; other site
648757005656	GTP/Mg2+ binding site [chemical binding]; other site
648757005657	Switch I region; other site
648757005658	G2 box; other site
648757005659	G3 box; other site
648757005660	Switch II region; other site
648757005661	G4 box; other site
648757005662	G5 box; other site
648757005663	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106
648757005664	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
648757005665	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
648757005666	active site
648757005667	catalytic tetrad [active]
648757005668	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
648757005669	Helix-turn-helix domains; Region: HTH; cl00088
648757005670	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
648757005671	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
648757005672	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
648757005673	Peptidase family M23; Region: Peptidase_M23; pfam01551
648757005674	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
648757005675	dimer interface [polypeptide binding]; other site
648757005676	pyridoxal binding site [chemical binding]; other site
648757005677	ATP binding site [chemical binding]; other site
648757005678	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
648757005679	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
648757005680	dimer interface [polypeptide binding]; other site
648757005681	conserved gate region; other site
648757005682	putative PBP binding loops; other site
648757005683	ABC-ATPase subunit interface; other site
648757005684	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
648757005685	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
648757005686	dimer interface [polypeptide binding]; other site
648757005687	conserved gate region; other site
648757005688	putative PBP binding loops; other site
648757005689	ABC-ATPase subunit interface; other site
648757005690	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
648757005691	putative phosphate binding site [ion binding]; other site
648757005692	putative catalytic site [active]
648757005693	active site
648757005694	metal binding site A [ion binding]; metal-binding site
648757005695	DNA binding site [nucleotide binding]
648757005696	putative AP binding site [nucleotide binding]; other site
648757005697	putative metal binding site B [ion binding]; other site
648757005698	Protein of unknown function (DUF3754); Region: DUF3754; pfam12576
648757005699	YadA-like C-terminal region; Region: YadA; pfam03895
648757005700	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
648757005701	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
648757005702	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
648757005703	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
648757005704	RNA binding site [nucleotide binding]; other site
648757005705	YcjX-like family, DUF463; Region: DUF463; cl01193
648757005706	hypothetical protein; Provisional; Region: PRK05415
648757005707	Domain of unknown function (DUF697); Region: DUF697; cl12064
648757005708	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
648757005709	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
648757005710	Helix-turn-helix domains; Region: HTH; cl00088
648757005711	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
648757005712	putative dimerization interface [polypeptide binding]; other site
648757005713	Domain of unknown function (DUF305); Region: DUF305; cl15795
648757005714	glucose-6-phosphate isomerase; Provisional; Region: PRK00973
648757005715	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
648757005716	active site
648757005717	dimer interface [polypeptide binding]; other site
648757005718	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
648757005719	dimer interface [polypeptide binding]; other site
648757005720	active site
648757005721	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
648757005722	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757005723	ATP binding site [chemical binding]; other site
648757005724	Mg2+ binding site [ion binding]; other site
648757005725	G-X-G motif; other site
648757005726	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
648757005727	ATP binding site [chemical binding]; other site
648757005728	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
648757005729	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
648757005730	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
648757005731	metal binding site [ion binding]; metal-binding site
648757005732	Transcriptional regulator [Transcription]; Region: LysR; COG0583
648757005733	Helix-turn-helix domains; Region: HTH; cl00088
648757005734	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
648757005735	dimerization interface [polypeptide binding]; other site
648757005736	CsbD-like; Region: CsbD; cl15799
648757005737	Isochorismatase family; Region: Isochorismatase; pfam00857
648757005738	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
648757005739	catalytic triad [active]
648757005740	dimer interface [polypeptide binding]; other site
648757005741	conserved cis-peptide bond; other site
648757005742	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
648757005743	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
648757005744	Substrate binding site; other site
648757005745	Cupin domain; Region: Cupin_2; cl09118
648757005746	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
648757005747	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
648757005748	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
648757005749	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
648757005750	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
648757005751	catalytic center binding site [active]
648757005752	ATP binding site [chemical binding]; other site
648757005753	Uncharacterized conserved protein [Function unknown]; Region: COG1432
648757005754	LabA_like proteins; Region: LabA; cd10911
648757005755	putative metal binding site [ion binding]; other site
648757005756	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
648757005757	Fe-S cluster binding site [ion binding]; other site
648757005758	DNA binding site [nucleotide binding]
648757005759	active site
648757005760	Protein of unknown function (DUF3775); Region: DUF3775; pfam12616
648757005761	Helix-turn-helix domains; Region: HTH; cl00088
648757005762	Winged helix-turn helix; Region: HTH_29; pfam13551
648757005763	Helix-turn-helix domains; Region: HTH; cl00088
648757005764	Integrase core domain; Region: rve; cl01316
648757005765	Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898
648757005766	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223
648757005767	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
648757005768	active site
648757005769	Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602
648757005770	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
648757005771	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
648757005772	domain interfaces; other site
648757005773	active site
648757005774	UGMP family protein; Validated; Region: PRK09604
648757005775	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
648757005776	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
648757005777	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757005778	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
648757005779	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
648757005780	Phospholipid methyltransferase; Region: PEMT; cl00763
648757005781	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
648757005782	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
648757005783	putative dimer interface [polypeptide binding]; other site
648757005784	active site pocket [active]
648757005785	putative cataytic base [active]
648757005786	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
648757005787	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
648757005788	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
648757005789	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
648757005790	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
648757005791	Fibrinogen binding protein; Region: Fibrinogen_BP; pfam08017
648757005792	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
648757005793	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
648757005794	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757005795	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
648757005796	succinyldiaminopimelate transaminase; Region: DapC_gpp; TIGR03538
648757005797	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
648757005798	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757005799	homodimer interface [polypeptide binding]; other site
648757005800	catalytic residue [active]
648757005801	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
648757005802	Nitrogen regulatory protein P-II; Region: P-II; cl00412
648757005803	Nitrogen regulatory protein P-II; Region: P-II; smart00938
648757005804	YceI-like domain; Region: YceI; cl01001
648757005805	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
648757005806	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
648757005807	DNA binding site [nucleotide binding]
648757005808	catalytic residue [active]
648757005809	H2TH interface [polypeptide binding]; other site
648757005810	putative catalytic residues [active]
648757005811	turnover-facilitating residue; other site
648757005812	intercalation triad [nucleotide binding]; other site
648757005813	8OG recognition residue [nucleotide binding]; other site
648757005814	putative reading head residues; other site
648757005815	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
648757005816	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
648757005817	enoyl-CoA hydratase; Provisional; Region: PRK05862
648757005818	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
648757005819	substrate binding site [chemical binding]; other site
648757005820	oxyanion hole (OAH) forming residues; other site
648757005821	trimer interface [polypeptide binding]; other site
648757005822	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
648757005823	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
648757005824	ligand binding site [chemical binding]; other site
648757005825	flexible hinge region; other site
648757005826	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
648757005827	putative switch regulator; other site
648757005828	non-specific DNA interactions [nucleotide binding]; other site
648757005829	DNA binding site [nucleotide binding]
648757005830	sequence specific DNA binding site [nucleotide binding]; other site
648757005831	putative cAMP binding site [chemical binding]; other site
648757005832	Cytochrome c; Region: Cytochrom_C; cl11414
648757005833	GatB domain; Region: GatB_Yqey; cl11497
648757005834	Pirin-related protein [General function prediction only]; Region: COG1741
648757005835	Cupin domain; Region: Cupin_2; cl09118
648757005836	CrcB-like protein; Region: CRCB; cl09114
648757005837	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
648757005838	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
648757005839	DNA photolyase; Region: DNA_photolyase; pfam00875
648757005840	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
648757005841	N-formylglutamate amidohydrolase; Region: FGase; cl01522
648757005842	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
648757005843	active site
648757005844	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
648757005845	Iron permease FTR1 family; Region: FTR1; cl00475
648757005846	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
648757005847	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
648757005848	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
648757005849	protein binding site [polypeptide binding]; other site
648757005850	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
648757005851	protein binding site [polypeptide binding]; other site
648757005852	tellurite resistance protein terB; Region: terB; cd07176
648757005853	putative metal binding site [ion binding]; other site
648757005854	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
648757005855	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
648757005856	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
648757005857	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
648757005858	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
648757005859	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
648757005860	FeS/SAM binding site; other site
648757005861	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
648757005862	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
648757005863	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
648757005864	P loop; other site
648757005865	GTP binding site [chemical binding]; other site
648757005866	Intracellular septation protein A; Region: IspA; cl01098
648757005867	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
648757005868	Helix-turn-helix domains; Region: HTH; cl00088
648757005869	Helix-turn-helix domains; Region: HTH; cl00088
648757005870	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
648757005871	Coenzyme A binding pocket [chemical binding]; other site
648757005872	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
648757005873	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
648757005874	putative C-terminal domain interface [polypeptide binding]; other site
648757005875	putative GSH binding site (G-site) [chemical binding]; other site
648757005876	putative dimer interface [polypeptide binding]; other site
648757005877	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
648757005878	dimer interface [polypeptide binding]; other site
648757005879	N-terminal domain interface [polypeptide binding]; other site
648757005880	putative substrate binding pocket (H-site) [chemical binding]; other site
648757005881	putative cation:proton antiport protein; Provisional; Region: PRK10669
648757005882	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
648757005883	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757005884	TfoX N-terminal domain; Region: TfoX_N; cl01167
648757005885	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
648757005886	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757005887	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
648757005888	Bacterial SH3 domain; Region: SH3_3; cl02551
648757005889	Bacterial SH3 domain; Region: SH3_3; cl02551
648757005890	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
648757005891	methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423
648757005892	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
648757005893	substrate binding site [chemical binding]; other site
648757005894	oxyanion hole (OAH) forming residues; other site
648757005895	trimer interface [polypeptide binding]; other site
648757005896	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
648757005897	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003
648757005898	active site
648757005899	hydrophilic channel; other site
648757005900	dimerization interface [polypeptide binding]; other site
648757005901	catalytic residues [active]
648757005902	active site lid [active]
648757005903	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261
648757005904	orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455
648757005905	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
648757005906	active site
648757005907	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
648757005908	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
648757005909	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
648757005910	synthetase active site [active]
648757005911	NTP binding site [chemical binding]; other site
648757005912	metal binding site [ion binding]; metal-binding site
648757005913	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
648757005914	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
648757005915	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
648757005916	membrane ATPase/protein kinase; Provisional; Region: PRK09435
648757005917	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
648757005918	Walker A; other site
648757005919	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
648757005920	putative substrate binding pocket [chemical binding]; other site
648757005921	AC domain interface; other site
648757005922	catalytic triad [active]
648757005923	AB domain interface; other site
648757005924	interchain disulfide; other site
648757005925	twin-arg-translocated uncharacterized repeat protein; Region: RR_plus_rpt_1; TIGR03808
648757005926	twin-arg-translocated uncharacterized repeat protein; Region: RR_plus_rpt_1; TIGR03808
648757005927	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
648757005928	Transglycosylase; Region: Transgly; cl07896
648757005929	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
648757005930	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
648757005931	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
648757005932	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757005933	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
648757005934	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757005935	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
648757005936	putative C-terminal domain interface [polypeptide binding]; other site
648757005937	putative GSH binding site (G-site) [chemical binding]; other site
648757005938	putative dimer interface [polypeptide binding]; other site
648757005939	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
648757005940	putative substrate binding pocket (H-site) [chemical binding]; other site
648757005941	putative N-terminal domain interface [polypeptide binding]; other site
648757005942	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
648757005943	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
648757005944	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
648757005945	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757005946	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
648757005947	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
648757005948	PYR/PP interface [polypeptide binding]; other site
648757005949	dimer interface [polypeptide binding]; other site
648757005950	TPP binding site [chemical binding]; other site
648757005951	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
648757005952	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
648757005953	TPP-binding site [chemical binding]; other site
648757005954	dimer interface [polypeptide binding]; other site
648757005955	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
648757005956	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
648757005957	putative valine binding site [chemical binding]; other site
648757005958	dimer interface [polypeptide binding]; other site
648757005959	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
648757005960	ketol-acid reductoisomerase; Provisional; Region: PRK05479
648757005961	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757005962	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
648757005963	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
648757005964	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
648757005965	trimer interface [polypeptide binding]; other site
648757005966	active site
648757005967	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
648757005968	Flavoprotein; Region: Flavoprotein; cl08021
648757005969	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
648757005970	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
648757005971	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
648757005972	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
648757005973	tandem repeat interface [polypeptide binding]; other site
648757005974	oligomer interface [polypeptide binding]; other site
648757005975	active site residues [active]
648757005976	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
648757005977	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757005978	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
648757005979	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
648757005980	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
648757005981	substrate binding pocket [chemical binding]; other site
648757005982	chain length determination region; other site
648757005983	substrate-Mg2+ binding site; other site
648757005984	catalytic residues [active]
648757005985	aspartate-rich region 1; other site
648757005986	active site lid residues [active]
648757005987	aspartate-rich region 2; other site
648757005988	AIR carboxylase; Region: AIRC; cl00310
648757005989	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
648757005990	XdhC Rossmann domain; Region: XdhC_C; pfam13478
648757005991	ATP-grasp domain; Region: ATP-grasp_4; cl03087
648757005992	Ribosomal protein S21; Region: Ribosomal_S21; cl00529
648757005993	TPR repeat; Region: TPR_11; pfam13414
648757005994	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
648757005995	binding surface
648757005996	TPR motif; other site
648757005997	TPR repeat; Region: TPR_11; pfam13414
648757005998	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
648757005999	binding surface
648757006000	TPR motif; other site
648757006001	Tetratricopeptide repeat; Region: TPR_9; pfam13371
648757006002	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
648757006003	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
648757006004	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
648757006005	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
648757006006	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
648757006007	catalytic residue [active]
648757006008	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
648757006009	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
648757006010	active site
648757006011	phosphorylation site [posttranslational modification]
648757006012	intermolecular recognition site; other site
648757006013	dimerization interface [polypeptide binding]; other site
648757006014	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
648757006015	BA14K-like protein; Region: BA14K; pfam07886
648757006016	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
648757006017	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
648757006018	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
648757006019	tetrameric interface [polypeptide binding]; other site
648757006020	NAD binding site [chemical binding]; other site
648757006021	catalytic residues [active]
648757006022	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
648757006023	active site
648757006024	catalytic triad [active]
648757006025	oxyanion hole [active]
648757006026	switch loop; other site
648757006027	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
648757006028	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
648757006029	Walker A/P-loop; other site
648757006030	ATP binding site [chemical binding]; other site
648757006031	Q-loop/lid; other site
648757006032	ABC transporter signature motif; other site
648757006033	Walker B; other site
648757006034	D-loop; other site
648757006035	H-loop/switch region; other site
648757006036	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
648757006037	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
648757006038	FtsX-like permease family; Region: FtsX; cl15850
648757006039	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
648757006040	Protein of unknown function (DUF2794); Region: DUF2794; pfam10984
648757006041	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
648757006042	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
648757006043	chaperone protein DnaJ; Provisional; Region: PRK10767
648757006044	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
648757006045	HSP70 interaction site [polypeptide binding]; other site
648757006046	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
648757006047	substrate binding site [polypeptide binding]; other site
648757006048	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
648757006049	Zn binding sites [ion binding]; other site
648757006050	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
648757006051	dimer interface [polypeptide binding]; other site
648757006052	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
648757006053	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
648757006054	DNA binding site [nucleotide binding]
648757006055	Permease; Region: Permease; cl00510
648757006056	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
648757006057	ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261
648757006058	Walker A/P-loop; other site
648757006059	ATP binding site [chemical binding]; other site
648757006060	Q-loop/lid; other site
648757006061	ABC transporter signature motif; other site
648757006062	Walker B; other site
648757006063	D-loop; other site
648757006064	H-loop/switch region; other site
648757006065	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
648757006066	mce related protein; Region: MCE; pfam02470
648757006067	Protein of unknown function (DUF330); Region: DUF330; cl01135
648757006068	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
648757006069	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
648757006070	putative C-terminal domain interface [polypeptide binding]; other site
648757006071	putative GSH binding site (G-site) [chemical binding]; other site
648757006072	putative dimer interface [polypeptide binding]; other site
648757006073	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
648757006074	N-terminal domain interface [polypeptide binding]; other site
648757006075	dimer interface [polypeptide binding]; other site
648757006076	substrate binding pocket (H-site) [chemical binding]; other site
648757006077	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
648757006078	PUCC protein; Region: PUCC; pfam03209
648757006079	glutathione reductase; Validated; Region: PRK06116
648757006080	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
648757006081	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
648757006082	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
648757006083	tetramer (dimer of dimers) interface [polypeptide binding]; other site
648757006084	active site
648757006085	dimer interface [polypeptide binding]; other site
648757006086	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
648757006087	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
648757006088	tetramerization interface [polypeptide binding]; other site
648757006089	NAD(P) binding site [chemical binding]; other site
648757006090	catalytic residues [active]
648757006091	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
648757006092	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
648757006093	active site
648757006094	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
648757006095	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
648757006096	active site
648757006097	HIGH motif; other site
648757006098	KMSKS motif; other site
648757006099	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
648757006100	tRNA binding surface [nucleotide binding]; other site
648757006101	anticodon binding site; other site
648757006102	DNA polymerase III subunit delta'; Validated; Region: PRK07471
648757006103	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757006104	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
648757006105	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227
648757006106	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757006107	Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839
648757006108	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
648757006109	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
648757006110	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
648757006111	S-adenosylmethionine binding site [chemical binding]; other site
648757006112	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757006113	Protein kinase domain; Region: Pkinase; pfam00069
648757006114	Catalytic domain of Protein Kinases; Region: PKc; cd00180
648757006115	active site
648757006116	ATP binding site [chemical binding]; other site
648757006117	substrate binding site [chemical binding]; other site
648757006118	activation loop (A-loop); other site
648757006119	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
648757006120	Ligand Binding Site [chemical binding]; other site
648757006121	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
648757006122	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
648757006123	active site
648757006124	metal binding site [ion binding]; metal-binding site
648757006125	Protein of unknown function (DUF1254); Region: DUF1254; cl02257
648757006126	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
648757006127	Transglycosylase; Region: Transgly; cl07896
648757006128	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
648757006129	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
648757006130	Flagellin N-methylase; Region: FliB; cl00497
648757006131	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
648757006132	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757006133	active site
648757006134	phosphorylation site [posttranslational modification]
648757006135	intermolecular recognition site; other site
648757006136	dimerization interface [polypeptide binding]; other site
648757006137	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
648757006138	DNA binding site [nucleotide binding]
648757006139	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
648757006140	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757006141	ATP binding site [chemical binding]; other site
648757006142	Mg2+ binding site [ion binding]; other site
648757006143	G-X-G motif; other site
648757006144	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
648757006145	NMT1-like family; Region: NMT1_2; cl15260
648757006146	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
648757006147	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
648757006148	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
648757006149	active site
648757006150	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
648757006151	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
648757006152	dimer interface [polypeptide binding]; other site
648757006153	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757006154	catalytic residue [active]
648757006155	Protein of unknown function (DUF1489); Region: DUF1489; cl11570
648757006156	Protein of unknown function (DUF465); Region: DUF465; cl01070
648757006157	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
648757006158	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
648757006159	dimer interface [polypeptide binding]; other site
648757006160	motif 1; other site
648757006161	active site
648757006162	motif 2; other site
648757006163	motif 3; other site
648757006164	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
648757006165	anticodon binding site; other site
648757006166	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295
648757006167	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
648757006168	dimer interface [polypeptide binding]; other site
648757006169	motif 1; other site
648757006170	motif 2; other site
648757006171	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
648757006172	active site
648757006173	motif 3; other site
648757006174	ATP phosphoribosyltransferase; Region: HisG; cl15266
648757006175	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
648757006176	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
648757006177	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
648757006178	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
648757006179	active site
648757006180	nucleophile elbow; other site
648757006181	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
648757006182	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
648757006183	Walker A motif; other site
648757006184	ATP binding site [chemical binding]; other site
648757006185	Walker B motif; other site
648757006186	arginine finger; other site
648757006187	Disulfide bond chaperones of the HSP33 family [Posttranslational modification, protein turnover, chaperones]; Region: COG1281
648757006188	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
648757006189	dimerization interface [polypeptide binding]; other site
648757006190	domain crossover interface; other site
648757006191	redox-dependent activation switch; other site
648757006192	ornithine carbamoyltransferase; Provisional; Region: PRK00779
648757006193	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
648757006194	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757006195	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
648757006196	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
648757006197	inhibitor-cofactor binding pocket; inhibition site
648757006198	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757006199	catalytic residue [active]
648757006200	GcrA cell cycle regulator; Region: GcrA; cl11564
648757006201	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
648757006202	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757006203	active site
648757006204	phosphorylation site [posttranslational modification]
648757006205	intermolecular recognition site; other site
648757006206	dimerization interface [polypeptide binding]; other site
648757006207	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
648757006208	DNA binding site [nucleotide binding]
648757006209	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
648757006210	PhoU domain; Region: PhoU; pfam01895
648757006211	PhoU domain; Region: PhoU; pfam01895
648757006212	phosphate transporter ATP-binding protein; Provisional; Region: PRK14235
648757006213	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
648757006214	Walker A/P-loop; other site
648757006215	ATP binding site [chemical binding]; other site
648757006216	Q-loop/lid; other site
648757006217	ABC transporter signature motif; other site
648757006218	Walker B; other site
648757006219	D-loop; other site
648757006220	H-loop/switch region; other site
648757006221	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
648757006222	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
648757006223	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
648757006224	dimer interface [polypeptide binding]; other site
648757006225	conserved gate region; other site
648757006226	putative PBP binding loops; other site
648757006227	ABC-ATPase subunit interface; other site
648757006228	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
648757006229	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
648757006230	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
648757006231	dimer interface [polypeptide binding]; other site
648757006232	conserved gate region; other site
648757006233	putative PBP binding loops; other site
648757006234	ABC-ATPase subunit interface; other site
648757006235	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
648757006236	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
648757006237	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
648757006238	dimer interface [polypeptide binding]; other site
648757006239	phosphorylation site [posttranslational modification]
648757006240	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757006241	ATP binding site [chemical binding]; other site
648757006242	Mg2+ binding site [ion binding]; other site
648757006243	G-X-G motif; other site
648757006244	Protein of unknown function (DUF971); Region: DUF971; cl01414
648757006245	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
648757006246	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
648757006247	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
648757006248	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
648757006249	Walker A/P-loop; other site
648757006250	ATP binding site [chemical binding]; other site
648757006251	Q-loop/lid; other site
648757006252	ABC transporter signature motif; other site
648757006253	Walker B; other site
648757006254	D-loop; other site
648757006255	H-loop/switch region; other site
648757006256	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
648757006257	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
648757006258	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
648757006259	protein binding site [polypeptide binding]; other site
648757006260	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
648757006261	protein binding site [polypeptide binding]; other site
648757006262	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
648757006263	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757006264	ATP binding site [chemical binding]; other site
648757006265	G-X-G motif; other site
648757006266	mercuric reductase; Validated; Region: PRK06370
648757006267	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
648757006268	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
648757006269	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
648757006270	elongation factor G; Reviewed; Region: PRK12740
648757006271	G1 box; other site
648757006272	putative GEF interaction site [polypeptide binding]; other site
648757006273	GTP/Mg2+ binding site [chemical binding]; other site
648757006274	Switch I region; other site
648757006275	G2 box; other site
648757006276	G3 box; other site
648757006277	Switch II region; other site
648757006278	G4 box; other site
648757006279	G5 box; other site
648757006280	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
648757006281	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
648757006282	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
648757006283	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
648757006284	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
648757006285	substrate binding site [chemical binding]; other site
648757006286	glutamase interaction surface [polypeptide binding]; other site
648757006287	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
648757006288	4Fe-4S binding domain; Region: Fer4_5; pfam12801
648757006289	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
648757006290	Fe2+ transport protein; Region: Iron_transport; cl01377
648757006291	Fe2+ transport protein; Region: Iron_transport; cl01377
648757006292	Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659
648757006293	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
648757006294	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
648757006295	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
648757006296	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
648757006297	biotin carboxylase; Validated; Region: PRK08462
648757006298	ATP-grasp domain; Region: ATP-grasp_4; cl03087
648757006299	diaminopimelate decarboxylase; Region: lysA; TIGR01048
648757006300	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
648757006301	active site
648757006302	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
648757006303	substrate binding site [chemical binding]; other site
648757006304	catalytic residues [active]
648757006305	dimer interface [polypeptide binding]; other site
648757006306	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
648757006307	argininosuccinate lyase; Provisional; Region: PRK00855
648757006308	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
648757006309	active sites [active]
648757006310	tetramer interface [polypeptide binding]; other site
648757006311	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
648757006312	catalytic residues [active]
648757006313	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
648757006314	FAD binding domain; Region: FAD_binding_4; pfam01565
648757006315	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
648757006316	sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168
648757006317	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
648757006318	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
648757006319	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814
648757006320	thymidylate kinase; Validated; Region: tmk; PRK00698
648757006321	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
648757006322	TMP-binding site; other site
648757006323	ATP-binding site [chemical binding]; other site
648757006324	DNA ligase, ATP-dependent, PP_1105 family; Region: DNA_lig_bact; TIGR04120
648757006325	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
648757006326	active site
648757006327	DNA binding site [nucleotide binding]
648757006328	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
648757006329	DNA binding site [nucleotide binding]
648757006330	Protein of unknown function (DUF1491); Region: DUF1491; cl11568
648757006331	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
648757006332	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
648757006333	DNA polymerase III subunit alpha; Reviewed; Region: PRK07373
648757006334	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
648757006335	generic binding surface II; other site
648757006336	generic binding surface I; other site
648757006337	Y-family of DNA polymerases; Region: PolY; cl12025
648757006338	DNA Polymerase Y-family; Region: PolY_like; cd03468
648757006339	DNA binding site [nucleotide binding]
648757006340	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
648757006341	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
648757006342	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
648757006343	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
648757006344	NAD(P) binding site [chemical binding]; other site
648757006345	catalytic residues [active]
648757006346	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
648757006347	Mechanosensitive ion channel; Region: MS_channel; pfam00924
648757006348	Phosphate-starvation-inducible E; Region: PsiE; cl01264
648757006349	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
648757006350	ThiC-associated domain; Region: ThiC-associated; pfam13667
648757006351	ThiC family; Region: ThiC; cl08031
648757006352	Helix-turn-helix domains; Region: HTH; cl00088
648757006353	Winged helix-turn helix; Region: HTH_29; pfam13551
648757006354	Integrase core domain; Region: rve; cl01316
648757006355	DDE domain; Region: DDE_Tnp_IS240; pfam13610
648757006356	Integrase core domain; Region: rve_3; cl15866
648757006357	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
648757006358	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
648757006359	Membrane transport protein; Region: Mem_trans; cl09117
648757006360	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
648757006361	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
648757006362	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
648757006363	phosphoglycolate phosphatase; Provisional; Region: PRK13222
648757006364	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
648757006365	motif II; other site
648757006366	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
648757006367	transposase/IS protein; Provisional; Region: PRK09183
648757006368	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
648757006369	Walker A motif; other site
648757006370	ATP binding site [chemical binding]; other site
648757006371	Walker B motif; other site
648757006372	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
648757006373	Catalytic site [active]
648757006374	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
648757006375	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
648757006376	Integrase core domain; Region: rve; cl01316
648757006377	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
648757006378	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
648757006379	Helix-turn-helix domains; Region: HTH; cl00088
648757006380	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
648757006381	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
648757006382	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
648757006383	TPR motif; other site
648757006384	binding surface
648757006385	TPR repeat; Region: TPR_11; pfam13414
648757006386	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
648757006387	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
648757006388	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
648757006389	active site
648757006390	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757006391	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757006392	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
648757006393	NAD(P) binding site [chemical binding]; other site
648757006394	active site
648757006395	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
648757006396	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
648757006397	NADP-binding site; other site
648757006398	homotetramer interface [polypeptide binding]; other site
648757006399	substrate binding site [chemical binding]; other site
648757006400	homodimer interface [polypeptide binding]; other site
648757006401	active site
648757006402	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
648757006403	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
648757006404	Substrate binding site; other site
648757006405	Cupin domain; Region: Cupin_2; cl09118
648757006406	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
648757006407	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
648757006408	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
648757006409	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
648757006410	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
648757006411	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
648757006412	TPR repeat; Region: TPR_11; pfam13414
648757006413	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
648757006414	binding surface
648757006415	TPR motif; other site
648757006416	TPR repeat; Region: TPR_11; pfam13414
648757006417	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
648757006418	FeS/SAM binding site; other site
648757006419	Radical SAM superfamily; Region: Radical_SAM; pfam04055
648757006420	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
648757006421	polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010
648757006422	ABC-2 type transporter; Region: ABC2_membrane; cl11417
648757006423	polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010
648757006424	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
648757006425	ABC_KpsT_Wzt   The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export.  Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220
648757006426	Walker A/P-loop; other site
648757006427	ATP binding site [chemical binding]; other site
648757006428	Q-loop/lid; other site
648757006429	ABC transporter signature motif; other site
648757006430	Walker B; other site
648757006431	D-loop; other site
648757006432	H-loop/switch region; other site
648757006433	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
648757006434	Helix-turn-helix domains; Region: HTH; cl00088
648757006435	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
648757006436	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
648757006437	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
648757006438	Integrase core domain; Region: rve; cl01316
648757006439	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
648757006440	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
648757006441	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
648757006442	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
648757006443	active site
648757006444	substrate binding site [chemical binding]; other site
648757006445	metal binding site [ion binding]; metal-binding site
648757006446	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
648757006447	oligomeric interface; other site
648757006448	putative active site [active]
648757006449	homodimer interface [polypeptide binding]; other site
648757006450	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
648757006451	conjugal transfer relaxase TraI; Provisional; Region: PRK13878
648757006452	Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584
648757006453	Domain of unknown function (DUF927); Region: DUF927; cl12098
648757006454	integrase; Provisional; Region: PRK09692
648757006455	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
648757006456	active site
648757006457	Int/Topo IB signature motif; other site
648757006458	Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538
648757006459	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
648757006460	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
648757006461	inhibitor-cofactor binding pocket; inhibition site
648757006462	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757006463	catalytic residue [active]
648757006464	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951
648757006465	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
648757006466	Cell morphogenesis central region; Region: MOR2-PAG1_mid; pfam14228
648757006467	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
648757006468	TROVE domain; Region: TROVE; pfam05731
648757006469	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
648757006470	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
648757006471	dipicolinate synthase subunit A; Reviewed; Region: PRK08306
648757006472	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
648757006473	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
648757006474	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
648757006475	FeS/SAM binding site; other site
648757006476	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
648757006477	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
648757006478	intersubunit interface [polypeptide binding]; other site
648757006479	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
648757006480	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
648757006481	Walker A/P-loop; other site
648757006482	ATP binding site [chemical binding]; other site
648757006483	Q-loop/lid; other site
648757006484	ABC transporter signature motif; other site
648757006485	Walker B; other site
648757006486	D-loop; other site
648757006487	H-loop/switch region; other site
648757006488	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
648757006489	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
648757006490	putative PBP binding regions; other site
648757006491	ABC-ATPase subunit  interface; other site
648757006492	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
648757006493	active site
648757006494	nucleotide binding site [chemical binding]; other site
648757006495	HIGH motif; other site
648757006496	KMSKS motif; other site
648757006497	Cysteine-rich small domain; Region: zf-like; cl00946
648757006498	cobyric acid synthase; Provisional; Region: PRK00784
648757006499	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757006500	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757006501	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
648757006502	catalytic triad [active]
648757006503	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
648757006504	active site
648757006505	catalytic residues [active]
648757006506	metal binding site [ion binding]; metal-binding site
648757006507	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
648757006508	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
648757006509	two-component response regulator; Provisional; Region: PRK09191
648757006510	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757006511	active site
648757006512	phosphorylation site [posttranslational modification]
648757006513	intermolecular recognition site; other site
648757006514	dimerization interface [polypeptide binding]; other site
648757006515	RNA polymerase sigma factor; Provisional; Region: PRK12547
648757006516	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
648757006517	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
648757006518	DNA binding residues [nucleotide binding]
648757006519	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
648757006520	CHASE3 domain; Region: CHASE3; cl05000
648757006521	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
648757006522	dimer interface [polypeptide binding]; other site
648757006523	phosphorylation site [posttranslational modification]
648757006524	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757006525	ATP binding site [chemical binding]; other site
648757006526	Mg2+ binding site [ion binding]; other site
648757006527	G-X-G motif; other site
648757006528	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
648757006529	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757006530	active site
648757006531	phosphorylation site [posttranslational modification]
648757006532	intermolecular recognition site; other site
648757006533	dimerization interface [polypeptide binding]; other site
648757006534	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757006535	active site
648757006536	phosphorylation site [posttranslational modification]
648757006537	intermolecular recognition site; other site
648757006538	Histidine kinase; Region: HisKA_2; cl06527
648757006539	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
648757006540	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757006541	ATP binding site [chemical binding]; other site
648757006542	Mg2+ binding site [ion binding]; other site
648757006543	G-X-G motif; other site
648757006544	Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509
648757006545	putative heme utilization radical SAM enzyme HutW; Region: rSAM_HutW; TIGR04107
648757006546	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
648757006547	FeS/SAM binding site; other site
648757006548	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
648757006549	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
648757006550	N-terminal plug; other site
648757006551	ligand-binding site [chemical binding]; other site
648757006552	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
648757006553	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
648757006554	Gram-negative bacterial tonB protein; Region: TonB; cl10048
648757006555	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
648757006556	dimerization interface [polypeptide binding]; other site
648757006557	putative DNA binding site [nucleotide binding]; other site
648757006558	putative Zn2+ binding site [ion binding]; other site
648757006559	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
648757006560	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
648757006561	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
648757006562	Protein export membrane protein; Region: SecD_SecF; cl14618
648757006563	FliP family; Region: FliP; cl00593
648757006564	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
648757006565	Flagellar L-ring protein; Region: FlgH; cl00905
648757006566	MgtE intracellular N domain; Region: MgtE_N; cl15244
648757006567	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
648757006568	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
648757006569	SAF domain; Region: SAF; cl00555
648757006570	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
648757006571	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
648757006572	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
648757006573	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782
648757006574	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
648757006575	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003
648757006576	Flagella basal body rod protein; Region: Flg_bb_rod; cl15793
648757006577	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
648757006578	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
648757006579	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
648757006580	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
648757006581	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
648757006582	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
648757006583	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
648757006584	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
648757006585	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
648757006586	dimer interface [polypeptide binding]; other site
648757006587	putative CheW interface [polypeptide binding]; other site
648757006588	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
648757006589	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757006590	active site
648757006591	phosphorylation site [posttranslational modification]
648757006592	intermolecular recognition site; other site
648757006593	dimerization interface [polypeptide binding]; other site
648757006594	CheB methylesterase; Region: CheB_methylest; pfam01339
648757006595	CheD chemotactic sensory transduction; Region: CheD; cl00810
648757006596	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
648757006597	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
648757006598	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757006599	PAS fold; Region: PAS_4; pfam08448
648757006600	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
648757006601	PAS domain; Region: PAS_9; pfam13426
648757006602	putative active site [active]
648757006603	heme pocket [chemical binding]; other site
648757006604	PAS domain; Region: PAS_9; pfam13426
648757006605	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
648757006606	putative active site [active]
648757006607	heme pocket [chemical binding]; other site
648757006608	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
648757006609	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
648757006610	dimer interface [polypeptide binding]; other site
648757006611	putative CheW interface [polypeptide binding]; other site
648757006612	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
648757006613	putative CheA interaction surface; other site
648757006614	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
648757006615	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
648757006616	putative binding surface; other site
648757006617	active site
648757006618	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
648757006619	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757006620	ATP binding site [chemical binding]; other site
648757006621	Mg2+ binding site [ion binding]; other site
648757006622	G-X-G motif; other site
648757006623	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
648757006624	Response regulator receiver domain; Region: Response_reg; pfam00072
648757006625	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757006626	active site
648757006627	phosphorylation site [posttranslational modification]
648757006628	intermolecular recognition site; other site
648757006629	dimerization interface [polypeptide binding]; other site
648757006630	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
648757006631	anti sigma factor interaction site; other site
648757006632	regulatory phosphorylation site [posttranslational modification]; other site
648757006633	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
648757006634	FliG C-terminal domain; Region: FliG_C; pfam01706
648757006635	Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868
648757006636	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
648757006637	Rod binding protein; Region: Rod-binding; cl01626
648757006638	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
648757006639	flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980
648757006640	FHIPEP family; Region: FHIPEP; pfam00771
648757006641	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
648757006642	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009
648757006643	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
648757006644	Flagellar protein FlbT; Region: FlbT; cl11455
648757006645	Flagellar protein FlaF; Region: FlaF; cl11454
648757006646	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008
648757006647	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
648757006648	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
648757006649	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521
648757006650	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
648757006651	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
648757006652	Flagella basal body rod protein; Region: Flg_bb_rod; cl15793
648757006653	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
648757006654	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
648757006655	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002
648757006656	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757006657	Walker A motif; other site
648757006658	ATP binding site [chemical binding]; other site
648757006659	Walker B motif; other site
648757006660	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642
648757006661	Flagella basal body rod protein; Region: Flg_bb_rod; cl15793
648757006662	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
648757006663	Response regulator receiver domain; Region: Response_reg; pfam00072
648757006664	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757006665	active site
648757006666	phosphorylation site [posttranslational modification]
648757006667	intermolecular recognition site; other site
648757006668	dimerization interface [polypeptide binding]; other site
648757006669	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
648757006670	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
648757006671	N-acetyl-D-glucosamine binding site [chemical binding]; other site
648757006672	Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269
648757006673	chemotaxis protein; Reviewed; Region: PRK12798
648757006674	flagellar motor protein MotB; Validated; Region: motB; PRK05996
648757006675	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
648757006676	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
648757006677	ligand binding site [chemical binding]; other site
648757006678	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
648757006679	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
648757006680	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
648757006681	flagellin; Reviewed; Region: PRK12687
648757006682	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
648757006683	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
648757006684	Cache domain; Region: Cache_2; cl07034
648757006685	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
648757006686	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
648757006687	dimer interface [polypeptide binding]; other site
648757006688	putative CheW interface [polypeptide binding]; other site
648757006689	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
648757006690	putative binding surface; other site
648757006691	active site
648757006692	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
648757006693	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757006694	ATP binding site [chemical binding]; other site
648757006695	Mg2+ binding site [ion binding]; other site
648757006696	G-X-G motif; other site
648757006697	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
648757006698	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
648757006699	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
648757006700	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
648757006701	active site
648757006702	FMN binding site [chemical binding]; other site
648757006703	substrate binding site [chemical binding]; other site
648757006704	homotetramer interface [polypeptide binding]; other site
648757006705	catalytic residue [active]
648757006706	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
648757006707	binding surface
648757006708	TPR repeat; Region: TPR_11; pfam13414
648757006709	TPR motif; other site
648757006710	TPR repeat; Region: TPR_11; pfam13414
648757006711	TPR repeat; Region: TPR_11; pfam13414
648757006712	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
648757006713	binding surface
648757006714	TPR motif; other site
648757006715	TPR repeat; Region: TPR_11; pfam13414
648757006716	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
648757006717	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
648757006718	putative ligand binding site [chemical binding]; other site
648757006719	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
648757006720	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
648757006721	active site
648757006722	Zn binding site [ion binding]; other site
648757006723	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
648757006724	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
648757006725	Ligand Binding Site [chemical binding]; other site
648757006726	Protein required for attachment to host cells; Region: Host_attach; cl02398
648757006727	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
648757006728	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
648757006729	S-adenosylmethionine binding site [chemical binding]; other site
648757006730	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
648757006731	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
648757006732	ATP-grasp domain; Region: ATP-grasp_4; cl03087
648757006733	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
648757006734	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
648757006735	carboxyltransferase (CT) interaction site; other site
648757006736	biotinylation site [posttranslational modification]; other site
648757006737	Domain of unknown function (DUF4389); Region: DUF4389; pfam14333
648757006738	Cupin domain; Region: Cupin_2; cl09118
648757006739	hypothetical protein; Provisional; Region: PRK12472
648757006740	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
648757006741	Fusaric acid resistance protein-like; Region: FUSC_2; cl15844
648757006742	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
648757006743	active site
648757006744	dimer interface [polypeptide binding]; other site
648757006745	metal binding site [ion binding]; metal-binding site
648757006746	shikimate kinase; Provisional; Region: PRK13946
648757006747	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
648757006748	ADP binding site [chemical binding]; other site
648757006749	magnesium binding site [ion binding]; other site
648757006750	putative shikimate binding site; other site
648757006751	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
648757006752	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
648757006753	DNA binding site [nucleotide binding]
648757006754	Int/Topo IB signature motif; other site
648757006755	active site
648757006756	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
648757006757	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
648757006758	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505
648757006759	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
648757006760	NAD binding site [chemical binding]; other site
648757006761	homotetramer interface [polypeptide binding]; other site
648757006762	homodimer interface [polypeptide binding]; other site
648757006763	substrate binding site [chemical binding]; other site
648757006764	active site
648757006765	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
648757006766	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
648757006767	dimer interface [polypeptide binding]; other site
648757006768	active site
648757006769	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
648757006770	active site 2 [active]
648757006771	active site 1 [active]
648757006772	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
648757006773	metal binding site 2 [ion binding]; metal-binding site
648757006774	putative DNA binding helix; other site
648757006775	metal binding site 1 [ion binding]; metal-binding site
648757006776	dimer interface [polypeptide binding]; other site
648757006777	structural Zn2+ binding site [ion binding]; other site
648757006778	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467
648757006779	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
648757006780	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
648757006781	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
648757006782	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
648757006783	substrate binding pocket [chemical binding]; other site
648757006784	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
648757006785	B12 binding site [chemical binding]; other site
648757006786	cobalt ligand [ion binding]; other site
648757006787	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
648757006788	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
648757006789	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
648757006790	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
648757006791	dimer interface [polypeptide binding]; other site
648757006792	conserved gate region; other site
648757006793	putative PBP binding loops; other site
648757006794	ABC-ATPase subunit interface; other site
648757006795	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
648757006796	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
648757006797	Walker A/P-loop; other site
648757006798	ATP binding site [chemical binding]; other site
648757006799	Q-loop/lid; other site
648757006800	ABC transporter signature motif; other site
648757006801	Walker B; other site
648757006802	D-loop; other site
648757006803	H-loop/switch region; other site
648757006804	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; cl15413
648757006805	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
648757006806	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757006807	Walker A/P-loop; other site
648757006808	ATP binding site [chemical binding]; other site
648757006809	Q-loop/lid; other site
648757006810	ABC transporter signature motif; other site
648757006811	Walker B; other site
648757006812	D-loop; other site
648757006813	H-loop/switch region; other site
648757006814	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
648757006815	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
648757006816	substrate binding pocket [chemical binding]; other site
648757006817	membrane-bound complex binding site; other site
648757006818	hinge residues; other site
648757006819	NlpC/P60 family; Region: NLPC_P60; cl11438
648757006820	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
648757006821	interface (dimer of trimers) [polypeptide binding]; other site
648757006822	Substrate-binding/catalytic site; other site
648757006823	Zn-binding sites [ion binding]; other site
648757006824	Type IV leader peptidase family; Region: Peptidase_A24; cl02077
648757006825	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
648757006826	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
648757006827	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
648757006828	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757006829	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
648757006830	Helix-turn-helix domains; Region: HTH; cl00088
648757006831	Protein of unknown function (DUF3422); Region: DUF3422; cl02073
648757006832	Haemolysin-III related; Region: HlyIII; cl03831
648757006833	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
648757006834	substrate binding site [chemical binding]; other site
648757006835	amidase; Provisional; Region: PRK07869
648757006836	Amidase; Region: Amidase; cl11426
648757006837	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
648757006838	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
648757006839	S-adenosylmethionine binding site [chemical binding]; other site
648757006840	tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238
648757006841	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
648757006842	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
648757006843	catalytic residue [active]
648757006844	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345
648757006845	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
648757006846	putative NAD(P) binding site [chemical binding]; other site
648757006847	active site
648757006848	FxsA cytoplasmic membrane protein; Region: FxsA; cl01148
648757006849	Tim44-like domain; Region: Tim44; cl09208
648757006850	MltA specific insert domain; Region: MltA; cl08398
648757006851	3D domain; Region: 3D; cl01439
648757006852	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
648757006853	Smr domain; Region: Smr; cl02619
648757006854	cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657
648757006855	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
648757006856	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757006857	Walker A/P-loop; other site
648757006858	ATP binding site [chemical binding]; other site
648757006859	Q-loop/lid; other site
648757006860	ABC transporter signature motif; other site
648757006861	Walker B; other site
648757006862	D-loop; other site
648757006863	H-loop/switch region; other site
648757006864	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
648757006865	Ligand binding site; other site
648757006866	Putative Catalytic site; other site
648757006867	DXD motif; other site
648757006868	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627
648757006869	Rrf2 family protein; Region: rrf2_super; TIGR00738
648757006870	Helix-turn-helix domains; Region: HTH; cl00088
648757006871	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
648757006872	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
648757006873	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757006874	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
648757006875	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
648757006876	ATP binding site [chemical binding]; other site
648757006877	Mg++ binding site [ion binding]; other site
648757006878	motif III; other site
648757006879	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
648757006880	nucleotide binding region [chemical binding]; other site
648757006881	ATP-binding site [chemical binding]; other site
648757006882	DbpA RNA binding domain; Region: DbpA; pfam03880
648757006883	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727
648757006884	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
648757006885	S-adenosylmethionine binding site [chemical binding]; other site
648757006886	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
648757006887	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
648757006888	PYR/PP interface [polypeptide binding]; other site
648757006889	dimer interface [polypeptide binding]; other site
648757006890	TPP binding site [chemical binding]; other site
648757006891	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
648757006892	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
648757006893	TPP-binding site; other site
648757006894	dimer interface [polypeptide binding]; other site
648757006895	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
648757006896	SmpB-tmRNA interface; other site
648757006897	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
648757006898	dihydrodipicolinate synthase; Region: dapA; TIGR00674
648757006899	dimer interface [polypeptide binding]; other site
648757006900	active site
648757006901	catalytic residue [active]
648757006902	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
648757006903	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
648757006904	N-acetyl-D-glucosamine binding site [chemical binding]; other site
648757006905	catalytic residue [active]
648757006906	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
648757006907	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
648757006908	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
648757006909	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
648757006910	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
648757006911	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
648757006912	DNA-directed RNA polymerase, beta'' subunit; Region: rpoC2_cyan; TIGR02388
648757006913	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
648757006914	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
648757006915	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
648757006916	bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603
648757006917	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
648757006918	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
648757006919	DNA binding site [nucleotide binding]
648757006920	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
648757006921	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
648757006922	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
648757006923	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
648757006924	RPB12 interaction site [polypeptide binding]; other site
648757006925	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
648757006926	RPB11 interaction site [polypeptide binding]; other site
648757006927	RPB12 interaction site [polypeptide binding]; other site
648757006928	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
648757006929	RPB3 interaction site [polypeptide binding]; other site
648757006930	RPB1 interaction site [polypeptide binding]; other site
648757006931	RPB11 interaction site [polypeptide binding]; other site
648757006932	RPB10 interaction site [polypeptide binding]; other site
648757006933	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
648757006934	core dimer interface [polypeptide binding]; other site
648757006935	peripheral dimer interface [polypeptide binding]; other site
648757006936	L10 interface [polypeptide binding]; other site
648757006937	L11 interface [polypeptide binding]; other site
648757006938	putative EF-Tu interaction site [polypeptide binding]; other site
648757006939	putative EF-G interaction site [polypeptide binding]; other site
648757006940	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
648757006941	23S rRNA interface [nucleotide binding]; other site
648757006942	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
648757006943	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
648757006944	mRNA/rRNA interface [nucleotide binding]; other site
648757006945	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
648757006946	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
648757006947	23S rRNA interface [nucleotide binding]; other site
648757006948	L7/L12 interface [polypeptide binding]; other site
648757006949	putative thiostrepton binding site; other site
648757006950	L25 interface [polypeptide binding]; other site
648757006951	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
648757006952	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
648757006953	putative homodimer interface [polypeptide binding]; other site
648757006954	KOW motif; Region: KOW; cl00354
648757006955	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
648757006956	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
648757006957	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757006958	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
648757006959	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
648757006960	ParB-like partition proteins; Region: parB_part; TIGR00180
648757006961	ParB-like nuclease domain; Region: ParBc; cl02129
648757006962	KorB domain; Region: KorB; pfam08535
648757006963	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
648757006964	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
648757006965	P-loop; other site
648757006966	Magnesium ion binding site [ion binding]; other site
648757006967	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
648757006968	Magnesium ion binding site [ion binding]; other site
648757006969	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
648757006970	YARHG domain; Region: YARHG; pfam13308
648757006971	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
648757006972	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
648757006973	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757006974	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
648757006975	FOG: CBS domain [General function prediction only]; Region: COG0517
648757006976	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
648757006977	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
648757006978	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
648757006979	trmE is a tRNA modification GTPase; Region: trmE; cd04164
648757006980	G1 box; other site
648757006981	GTP/Mg2+ binding site [chemical binding]; other site
648757006982	Switch I region; other site
648757006983	G2 box; other site
648757006984	Switch II region; other site
648757006985	G3 box; other site
648757006986	G4 box; other site
648757006987	G5 box; other site
648757006988	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
648757006989	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
648757006990	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
648757006991	catalytic residues [active]
648757006992	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
648757006993	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
648757006994	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
648757006995	Integrase core domain; Region: rve; cl01316
648757006996	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
648757006997	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
648757006998	Helix-turn-helix domains; Region: HTH; cl00088
648757006999	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
648757007000	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
648757007001	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
648757007002	putative NADH binding site [chemical binding]; other site
648757007003	putative active site [active]
648757007004	nudix motif; other site
648757007005	putative metal binding site [ion binding]; other site
648757007006	pantothenate kinase; Provisional; Region: PRK05439
648757007007	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025
648757007008	ATP-binding site [chemical binding]; other site
648757007009	CoA-binding site [chemical binding]; other site
648757007010	Mg2+-binding site [ion binding]; other site
648757007011	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
648757007012	Cupin domain; Region: Cupin_2; cl09118
648757007013	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
648757007014	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
648757007015	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
648757007016	putative substrate translocation pore; other site
648757007017	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251
648757007018	SecA binding site; other site
648757007019	Preprotein binding site; other site
648757007020	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
648757007021	Autoinducer binding domain; Region: Autoind_bind; pfam03472
648757007022	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
648757007023	DNA binding residues [nucleotide binding]
648757007024	dimerization interface [polypeptide binding]; other site
648757007025	Helix-turn-helix domains; Region: HTH; cl00088
648757007026	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
648757007027	active site
648757007028	substrate binding site [chemical binding]; other site
648757007029	catalytic site [active]
648757007030	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
648757007031	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
648757007032	CoA-binding site [chemical binding]; other site
648757007033	ATP-binding [chemical binding]; other site
648757007034	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
648757007035	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
648757007036	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
648757007037	shikimate binding site; other site
648757007038	NAD(P) binding site [chemical binding]; other site
648757007039	Maf-like protein; Region: Maf; pfam02545
648757007040	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
648757007041	active site
648757007042	dimer interface [polypeptide binding]; other site
648757007043	Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780
648757007044	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
648757007045	substrate binding site [chemical binding]; other site
648757007046	active site
648757007047	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
648757007048	transcription termination factor Rho; Provisional; Region: rho; PRK09376
648757007049	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
648757007050	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
648757007051	RNA binding site [nucleotide binding]; other site
648757007052	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
648757007053	multimer interface [polypeptide binding]; other site
648757007054	Walker A motif; other site
648757007055	ATP binding site [chemical binding]; other site
648757007056	Walker B motif; other site
648757007057	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
648757007058	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
648757007059	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368
648757007060	Putative glucoamylase; Region: Glycoamylase; pfam10091
648757007061	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
648757007062	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
648757007063	Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome.  The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223
648757007064	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
648757007065	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
648757007066	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
648757007067	Fibronectin type III-like domain; Region: Fn3-like; cl15273
648757007068	Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957
648757007069	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
648757007070	TPP-binding site [chemical binding]; other site
648757007071	D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894
648757007072	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
648757007073	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
648757007074	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
648757007075	Found in ATP-dependent protease La (LON); Region: LON; smart00464
648757007076	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
648757007077	Walker A motif; other site
648757007078	ATP binding site [chemical binding]; other site
648757007079	Walker B motif; other site
648757007080	arginine finger; other site
648757007081	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
648757007082	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
648757007083	putative dimer interface [polypeptide binding]; other site
648757007084	Protein of unknown function (DUF3175); Region: DUF3175; pfam11373
648757007085	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
648757007086	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
648757007087	substrate binding pocket [chemical binding]; other site
648757007088	membrane-bound complex binding site; other site
648757007089	hinge residues; other site
648757007090	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
648757007091	dimer interface [polypeptide binding]; other site
648757007092	conserved gate region; other site
648757007093	putative PBP binding loops; other site
648757007094	ABC-ATPase subunit interface; other site
648757007095	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
648757007096	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
648757007097	dimer interface [polypeptide binding]; other site
648757007098	conserved gate region; other site
648757007099	putative PBP binding loops; other site
648757007100	ABC-ATPase subunit interface; other site
648757007101	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
648757007102	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
648757007103	Walker A/P-loop; other site
648757007104	ATP binding site [chemical binding]; other site
648757007105	Q-loop/lid; other site
648757007106	ABC transporter signature motif; other site
648757007107	Walker B; other site
648757007108	D-loop; other site
648757007109	H-loop/switch region; other site
648757007110	prephenate dehydratase; Provisional; Region: PRK11899
648757007111	Prephenate dehydratase; Region: PDT; pfam00800
648757007112	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
648757007113	putative L-Phe binding site [chemical binding]; other site
648757007114	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
648757007115	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
648757007116	DNA binding residues [nucleotide binding]
648757007117	LabA_like proteins; Region: LabA_like; cd06167
648757007118	putative metal binding site [ion binding]; other site
648757007119	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
648757007120	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
648757007121	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
648757007122	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
648757007123	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
648757007124	Helix-turn-helix domains; Region: HTH; cl00088
648757007125	Protein of unknown function (DUF992); Region: DUF992; pfam06186
648757007126	Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660
648757007127	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
648757007128	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
648757007129	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
648757007130	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
648757007131	Ligand binding site; other site
648757007132	Putative Catalytic site; other site
648757007133	DXD motif; other site
648757007134	GtrA-like protein; Region: GtrA; cl00971
648757007135	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
648757007136	Clp amino terminal domain; Region: Clp_N; pfam02861
648757007137	Clp amino terminal domain; Region: Clp_N; pfam02861
648757007138	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
648757007139	Walker A motif; other site
648757007140	ATP binding site [chemical binding]; other site
648757007141	Walker B motif; other site
648757007142	arginine finger; other site
648757007143	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
648757007144	Walker A motif; other site
648757007145	ATP binding site [chemical binding]; other site
648757007146	Walker B motif; other site
648757007147	arginine finger; other site
648757007148	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
648757007149	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
648757007150	MOSC domain; Region: MOSC; pfam03473
648757007151	Dehydratase family; Region: ILVD_EDD; cl00340
648757007152	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
648757007153	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
648757007154	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
648757007155	S-adenosylmethionine binding site [chemical binding]; other site
648757007156	peptide chain release factor 1; Validated; Region: prfA; PRK00591
648757007157	RF-1 domain; Region: RF-1; cl02875
648757007158	RF-1 domain; Region: RF-1; cl02875
648757007159	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
648757007160	GAF domain; Region: GAF; cl15785
648757007161	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
648757007162	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
648757007163	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
648757007164	aspartate kinase; Reviewed; Region: PRK06635
648757007165	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
648757007166	putative nucleotide binding site [chemical binding]; other site
648757007167	putative catalytic residues [active]
648757007168	putative Mg ion binding site [ion binding]; other site
648757007169	putative aspartate binding site [chemical binding]; other site
648757007170	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
648757007171	putative allosteric regulatory site; other site
648757007172	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
648757007173	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
648757007174	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
648757007175	S-adenosylmethionine binding site [chemical binding]; other site
648757007176	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
648757007177	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
648757007178	Coenzyme A binding pocket [chemical binding]; other site
648757007179	Uncharacterized conserved protein [Function unknown]; Region: COG3760
648757007180	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
648757007181	putative deacylase active site [active]
648757007182	Predicted amidohydrolase [General function prediction only]; Region: COG0388
648757007183	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
648757007184	putative active site [active]
648757007185	catalytic triad [active]
648757007186	dimer interface [polypeptide binding]; other site
648757007187	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
648757007188	GSH binding site [chemical binding]; other site
648757007189	catalytic residues [active]
648757007190	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
648757007191	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
648757007192	active site
648757007193	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757007194	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
648757007195	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868
648757007196	ABC transporter ATPase component; Reviewed; Region: PRK11147
648757007197	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
648757007198	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
648757007199	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
648757007200	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
648757007201	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
648757007202	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
648757007203	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
648757007204	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
648757007205	heme-binding site [chemical binding]; other site
648757007206	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
648757007207	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
648757007208	active site
648757007209	HIGH motif; other site
648757007210	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
648757007211	active site
648757007212	KMSKS motif; other site
648757007213	NAD synthetase; Provisional; Region: PRK13981
648757007214	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
648757007215	multimer interface [polypeptide binding]; other site
648757007216	active site
648757007217	catalytic triad [active]
648757007218	protein interface 1 [polypeptide binding]; other site
648757007219	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
648757007220	homodimer interface [polypeptide binding]; other site
648757007221	NAD binding pocket [chemical binding]; other site
648757007222	ATP binding pocket [chemical binding]; other site
648757007223	Mg binding site [ion binding]; other site
648757007224	active-site loop [active]
648757007225	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
648757007226	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
648757007227	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
648757007228	Protein of unknown function (DUF1656); Region: DUF1656; cl11658
648757007229	Fusaric acid resistance protein family; Region: FUSC; pfam04632
648757007230	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
648757007231	Helix-turn-helix domains; Region: HTH; cl00088
648757007232	Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827
648757007233	BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure; Region: KU; cd00109
648757007234	trypsin interaction site; other site
648757007235	ATP-grasp domain; Region: ATP-grasp_4; cl03087
648757007236	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
648757007237	dimerization interface [polypeptide binding]; other site
648757007238	PAS domain; Region: PAS_9; pfam13426
648757007239	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
648757007240	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
648757007241	dimer interface [polypeptide binding]; other site
648757007242	putative CheW interface [polypeptide binding]; other site
648757007243	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
648757007244	Chain length determinant protein; Region: Wzz; cl15801
648757007245	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
648757007246	Chain length determinant protein; Region: Wzz; cl15801
648757007247	Chain length determinant protein; Region: Wzz; cl15801
648757007248	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757007249	Helix-turn-helix domains; Region: HTH; cl00088
648757007250	Winged helix-turn helix; Region: HTH_29; pfam13551
648757007251	Integrase core domain; Region: rve; cl01316
648757007252	DDE domain; Region: DDE_Tnp_IS240; pfam13610
648757007253	Integrase core domain; Region: rve_3; cl15866
648757007254	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
648757007255	O-Antigen ligase; Region: Wzy_C; cl04850
648757007256	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
648757007257	Bacterial sugar transferase; Region: Bac_transf; cl00939
648757007258	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
648757007259	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
648757007260	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
648757007261	Uncharacterized conserved protein (DUF2190); Region: DUF2190; cl02289
648757007262	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
648757007263	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
648757007264	Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136
648757007265	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; cl05448
648757007266	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
648757007267	Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720
648757007268	Uncharacterized conserved protein [Function unknown]; Region: COG4983
648757007269	hypothetical protein; Provisional; Region: PRK14709
648757007270	D5 N terminal like; Region: D5_N; cl07360
648757007271	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
648757007272	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
648757007273	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
648757007274	DNA binding site [nucleotide binding]
648757007275	Int/Topo IB signature motif; other site
648757007276	active site
648757007277	CHC2 zinc finger; Region: zf-CHC2; cl15369
648757007278	conjugative transfer relaxase protein TraI; Region: TraI_TIGR; TIGR02760
648757007279	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
648757007280	Domain of unknown function (DUF927); Region: DUF927; cl12098
648757007281	TIR domain; Region: TIR_2; cl15770
648757007282	TIR domain; Region: TIR_2; cl15770
648757007283	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973
648757007284	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
648757007285	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
648757007286	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
648757007287	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
648757007288	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
648757007289	VirB7 interaction site; other site
648757007290	VirB8 protein; Region: VirB8; cl01500
648757007291	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
648757007292	Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314; cl02193
648757007293	conjugal transfer protein TrbE; Provisional; Region: PRK13891
648757007294	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
648757007295	Domain of unknown function DUF87; Region: DUF87; pfam01935
648757007296	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757007297	Walker B; other site
648757007298	D-loop; other site
648757007299	H-loop/switch region; other site
648757007300	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
648757007301	TrbC/VIRB2 family; Region: TrbC; cl01583
648757007302	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
648757007303	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
648757007304	ATP binding site [chemical binding]; other site
648757007305	Walker A motif; other site
648757007306	hexamer interface [polypeptide binding]; other site
648757007307	Walker B motif; other site
648757007308	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
648757007309	non-specific DNA binding site [nucleotide binding]; other site
648757007310	salt bridge; other site
648757007311	sequence-specific DNA binding site [nucleotide binding]; other site
648757007312	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
648757007313	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
648757007314	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
648757007315	conjugal transfer coupling protein TraG; Provisional; Region: PRK13880
648757007316	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757007317	Walker A motif; other site
648757007318	ATP binding site [chemical binding]; other site
648757007319	Walker B motif; other site
648757007320	Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584
648757007321	conjugal transfer relaxase TraI; Provisional; Region: PRK13878
648757007322	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
648757007323	Protein of unknown function (DUF805); Region: DUF805; cl01224
648757007324	PGDYG protein; Region: PGDYG; pfam14083
648757007325	Helix-turn-helix domains; Region: HTH; cl00088
648757007326	Winged helix-turn helix; Region: HTH_29; pfam13551
648757007327	Integrase core domain; Region: rve; cl01316
648757007328	DDE domain; Region: DDE_Tnp_IS240; pfam13610
648757007329	Integrase core domain; Region: rve_3; cl15866
648757007330	TIR domain; Region: TIR_2; cl15770
648757007331	Uncharacterized conserved protein [Function unknown]; Region: COG1262
648757007332	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
648757007333	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
648757007334	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
648757007335	putative active site [active]
648757007336	putative NTP binding site [chemical binding]; other site
648757007337	putative nucleic acid binding site [nucleotide binding]; other site
648757007338	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
648757007339	non-specific DNA binding site [nucleotide binding]; other site
648757007340	salt bridge; other site
648757007341	sequence-specific DNA binding site [nucleotide binding]; other site
648757007342	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
648757007343	TIR domain; Region: TIR_2; cl15770
648757007344	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757007345	sarco/endoplasmic reticulum calcium-translocating P-type ATPase; Region: ATPase-IIA1_Ca; TIGR01116
648757007346	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
648757007347	Tetratricopeptide repeat; Region: TPR_12; pfam13424
648757007348	Tetratricopeptide repeat; Region: TPR_12; pfam13424
648757007349	Tetratricopeptide repeat; Region: TPR_12; pfam13424
648757007350	CHAT domain; Region: CHAT; pfam12770
648757007351	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757007352	Tetratricopeptide repeat; Region: TPR_12; pfam13424
648757007353	Tetratricopeptide repeat; Region: TPR_12; pfam13424
648757007354	Tetratricopeptide repeat; Region: TPR_12; pfam13424
648757007355	Tetratricopeptide repeat; Region: TPR_12; pfam13424
648757007356	Tetratricopeptide repeat; Region: TPR_12; pfam13424
648757007357	Protein of unknown function DUF45; Region: DUF45; cl00636
648757007358	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
648757007359	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
648757007360	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
648757007361	ATP binding site [chemical binding]; other site
648757007362	putative Mg++ binding site [ion binding]; other site
648757007363	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
648757007364	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
648757007365	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
648757007366	Fic family protein [Function unknown]; Region: COG3177
648757007367	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
648757007368	Fic/DOC family; Region: Fic; cl00960
648757007369	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
648757007370	HsdM N-terminal domain; Region: HsdM_N; pfam12161
648757007371	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757007372	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757007373	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757007374	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
648757007375	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757007376	ATP binding site [chemical binding]; other site
648757007377	putative Mg++ binding site [ion binding]; other site
648757007378	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757007379	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757007380	Transposon-encoded protein TnpV; Region: TnpV; pfam14198
648757007381	conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877
648757007382	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757007383	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
648757007384	DNA binding site [nucleotide binding]
648757007385	Int/Topo IB signature motif; other site
648757007386	active site
648757007387	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
648757007388	trimer interface [polypeptide binding]; other site
648757007389	putative metal binding site [ion binding]; other site
648757007390	Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783
648757007391	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
648757007392	putative substrate translocation pore; other site
648757007393	Major Facilitator Superfamily; Region: MFS_1; pfam07690
648757007394	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
648757007395	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
648757007396	ring oligomerisation interface [polypeptide binding]; other site
648757007397	ATP/Mg binding site [chemical binding]; other site
648757007398	stacking interactions; other site
648757007399	hinge regions; other site
648757007400	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
648757007401	oligomerisation interface [polypeptide binding]; other site
648757007402	mobile loop; other site
648757007403	roof hairpin; other site
648757007404	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
648757007405	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
648757007406	putative active site [active]
648757007407	catalytic triad [active]
648757007408	putative dimer interface [polypeptide binding]; other site
648757007409	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
648757007410	non-specific DNA binding site [nucleotide binding]; other site
648757007411	salt bridge; other site
648757007412	sequence-specific DNA binding site [nucleotide binding]; other site
648757007413	S-adenosylmethionine synthetase; Validated; Region: PRK05250
648757007414	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
648757007415	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
648757007416	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
648757007417	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
648757007418	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
648757007419	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
648757007420	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
648757007421	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
648757007422	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
648757007423	TSCPD domain; Region: TSCPD; cl14834
648757007424	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
648757007425	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
648757007426	catalytic residue [active]
648757007427	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
648757007428	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
648757007429	HIGH motif; other site
648757007430	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
648757007431	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
648757007432	active site
648757007433	KMSKS motif; other site
648757007434	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
648757007435	tRNA binding surface [nucleotide binding]; other site
648757007436	Lipopolysaccharide-assembly; Region: LptE; cl01125
648757007437	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
648757007438	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
648757007439	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
648757007440	inhibitor-cofactor binding pocket; inhibition site
648757007441	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757007442	catalytic residue [active]
648757007443	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
648757007444	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
648757007445	active site
648757007446	interdomain interaction site; other site
648757007447	putative metal-binding site [ion binding]; other site
648757007448	nucleotide binding site [chemical binding]; other site
648757007449	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
648757007450	domain I; other site
648757007451	DNA binding groove [nucleotide binding]
648757007452	phosphate binding site [ion binding]; other site
648757007453	domain II; other site
648757007454	domain III; other site
648757007455	nucleotide binding site [chemical binding]; other site
648757007456	catalytic site [active]
648757007457	domain IV; other site
648757007458	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
648757007459	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
648757007460	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
648757007461	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
648757007462	ribonuclease R; Region: RNase_R; TIGR02063
648757007463	RNB domain; Region: RNB; pfam00773
648757007464	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471
648757007465	RNA binding site [nucleotide binding]; other site
648757007466	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
648757007467	Response regulator receiver domain; Region: Response_reg; pfam00072
648757007468	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757007469	active site
648757007470	phosphorylation site [posttranslational modification]
648757007471	intermolecular recognition site; other site
648757007472	dimerization interface [polypeptide binding]; other site
648757007473	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
648757007474	Rrf2 family protein; Region: rrf2_super; TIGR00738
648757007475	Helix-turn-helix domains; Region: HTH; cl00088
648757007476	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
648757007477	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
648757007478	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
648757007479	catalytic residue [active]
648757007480	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
648757007481	putative ABC transporter; Region: ycf24; CHL00085
648757007482	Domain of unknown function (DUF4267); Region: DUF4267; pfam14087
648757007483	FeS assembly ATPase SufC; Region: sufC; TIGR01978
648757007484	ABC-type transport system involved in Fe-S cluster assembly, ATPase component.  Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems.  The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217
648757007485	Walker A/P-loop; other site
648757007486	ATP binding site [chemical binding]; other site
648757007487	Q-loop/lid; other site
648757007488	ABC transporter signature motif; other site
648757007489	Walker B; other site
648757007490	D-loop; other site
648757007491	H-loop/switch region; other site
648757007492	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
648757007493	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
648757007494	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
648757007495	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
648757007496	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
648757007497	catalytic residue [active]
648757007498	Domain of unknown function DUF59; Region: DUF59; cl00941
648757007499	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
648757007500	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
648757007501	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
648757007502	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
648757007503	FtsX-like permease family; Region: FtsX; cl15850
648757007504	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
648757007505	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
648757007506	Walker A/P-loop; other site
648757007507	ATP binding site [chemical binding]; other site
648757007508	Q-loop/lid; other site
648757007509	ABC transporter signature motif; other site
648757007510	Walker B; other site
648757007511	D-loop; other site
648757007512	H-loop/switch region; other site
648757007513	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
648757007514	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
648757007515	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
648757007516	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
648757007517	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
648757007518	LemA family; Region: LemA; cl00742
648757007519	Repair protein; Region: Repair_PSII; cl01535
648757007520	Repair protein; Region: Repair_PSII; cl01535
648757007521	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
648757007522	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
648757007523	FAD binding pocket [chemical binding]; other site
648757007524	FAD binding motif [chemical binding]; other site
648757007525	phosphate binding motif [ion binding]; other site
648757007526	beta-alpha-beta structure motif; other site
648757007527	NAD binding pocket [chemical binding]; other site
648757007528	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
648757007529	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
648757007530	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
648757007531	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
648757007532	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
648757007533	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
648757007534	dimer interface [polypeptide binding]; other site
648757007535	conserved gate region; other site
648757007536	putative PBP binding loops; other site
648757007537	ABC-ATPase subunit interface; other site
648757007538	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
648757007539	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
648757007540	dimer interface [polypeptide binding]; other site
648757007541	conserved gate region; other site
648757007542	ABC-ATPase subunit interface; other site
648757007543	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
648757007544	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
648757007545	Walker A/P-loop; other site
648757007546	ATP binding site [chemical binding]; other site
648757007547	Q-loop/lid; other site
648757007548	ABC transporter signature motif; other site
648757007549	Walker B; other site
648757007550	D-loop; other site
648757007551	H-loop/switch region; other site
648757007552	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
648757007553	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
648757007554	Walker A/P-loop; other site
648757007555	ATP binding site [chemical binding]; other site
648757007556	Q-loop/lid; other site
648757007557	ABC transporter signature motif; other site
648757007558	Walker B; other site
648757007559	D-loop; other site
648757007560	H-loop/switch region; other site
648757007561	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
648757007562	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
648757007563	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
648757007564	substrate binding site [chemical binding]; other site
648757007565	oxyanion hole (OAH) forming residues; other site
648757007566	trimer interface [polypeptide binding]; other site
648757007567	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757007568	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
648757007569	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
648757007570	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
648757007571	classical (c) SDRs; Region: SDR_c; cd05233
648757007572	NAD(P) binding site [chemical binding]; other site
648757007573	active site
648757007574	Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173
648757007575	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
648757007576	putative active site [active]
648757007577	putative substrate binding site [chemical binding]; other site
648757007578	ATP binding site [chemical binding]; other site
648757007579	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
648757007580	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
648757007581	FAD binding site [chemical binding]; other site
648757007582	substrate binding site [chemical binding]; other site
648757007583	catalytic base [active]
648757007584	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
648757007585	nudix motif; other site
648757007586	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
648757007587	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
648757007588	Protein of unknown function (DUF1134); Region: DUF1134; cl02235
648757007589	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
648757007590	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
648757007591	putative substrate translocation pore; other site
648757007592	signal recognition particle protein; Provisional; Region: PRK10867
648757007593	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
648757007594	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
648757007595	P loop; other site
648757007596	GTP binding site [chemical binding]; other site
648757007597	Signal peptide binding domain; Region: SRP_SPB; pfam02978
648757007598	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
648757007599	RimM N-terminal domain; Region: RimM; pfam01782
648757007600	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828
648757007601	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
648757007602	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
648757007603	active site
648757007604	metal binding site [ion binding]; metal-binding site
648757007605	homotetramer interface [polypeptide binding]; other site
648757007606	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
648757007607	Acetokinase family; Region: Acetate_kinase; cl01029
648757007608	propionate/acetate kinase; Provisional; Region: PRK12379
648757007609	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
648757007610	ligand binding site [chemical binding]; other site
648757007611	flexible hinge region; other site
648757007612	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
648757007613	ligand binding site [chemical binding]; other site
648757007614	flexible hinge region; other site
648757007615	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
648757007616	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757007617	active site
648757007618	phosphorylation site [posttranslational modification]
648757007619	intermolecular recognition site; other site
648757007620	dimerization interface [polypeptide binding]; other site
648757007621	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
648757007622	DNA binding site [nucleotide binding]
648757007623	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253
648757007624	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
648757007625	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
648757007626	metal-binding site [ion binding]
648757007627	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
648757007628	FixH; Region: FixH; cl01254
648757007629	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
648757007630	4Fe-4S binding domain; Region: Fer4_5; pfam12801
648757007631	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
648757007632	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
648757007633	Cytochrome c; Region: Cytochrom_C; cl11414
648757007634	Cytochrome c; Region: Cytochrom_C; cl11414
648757007635	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
648757007636	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
648757007637	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130
648757007638	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
648757007639	Low-spin heme binding site [chemical binding]; other site
648757007640	Putative water exit pathway; other site
648757007641	Binuclear center (active site) [active]
648757007642	Putative proton exit pathway; other site
648757007643	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
648757007644	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
648757007645	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757007646	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
648757007647	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
648757007648	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
648757007649	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
648757007650	HSP70 interaction site [polypeptide binding]; other site
648757007651	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
648757007652	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
648757007653	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
648757007654	ligand binding site [chemical binding]; other site
648757007655	flexible hinge region; other site
648757007656	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
648757007657	putative switch regulator; other site
648757007658	non-specific DNA interactions [nucleotide binding]; other site
648757007659	DNA binding site [nucleotide binding]
648757007660	sequence specific DNA binding site [nucleotide binding]; other site
648757007661	putative cAMP binding site [chemical binding]; other site
648757007662	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
648757007663	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
648757007664	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
648757007665	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
648757007666	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
648757007667	SCP-2 sterol transfer family; Region: SCP2; cl01225
648757007668	Peptidase family U32; Region: Peptidase_U32; cl03113
648757007669	Peptidase family U32; Region: Peptidase_U32; cl03113
648757007670	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
648757007671	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
648757007672	active site residue [active]
648757007673	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
648757007674	active site residue [active]
648757007675	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
648757007676	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
648757007677	dimer interface [polypeptide binding]; other site
648757007678	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757007679	catalytic residue [active]
648757007680	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
648757007681	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
648757007682	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
648757007683	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
648757007684	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
648757007685	Surface antigen; Region: Bac_surface_Ag; cl03097
648757007686	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
648757007687	Helix-turn-helix domains; Region: HTH; cl00088
648757007688	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
648757007689	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
648757007690	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
648757007691	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
648757007692	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757007693	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490
648757007694	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
648757007695	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
648757007696	NAD binding site [chemical binding]; other site
648757007697	homodimer interface [polypeptide binding]; other site
648757007698	active site
648757007699	substrate binding site [chemical binding]; other site
648757007700	Uncharacterized conserved protein (DUF2293); Region: DUF2293; cl02373
648757007701	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
648757007702	active site
648757007703	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
648757007704	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
648757007705	Peptidase propeptide and YPEB domain; Region: PepSY; cl15815
648757007706	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
648757007707	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
648757007708	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
648757007709	catalytic residue [active]
648757007710	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
648757007711	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757007712	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
648757007713	putative L-serine binding site [chemical binding]; other site
648757007714	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
648757007715	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335
648757007716	putative ligand binding site [chemical binding]; other site
648757007717	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
648757007718	TM-ABC transporter signature motif; other site
648757007719	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
648757007720	TM-ABC transporter signature motif; other site
648757007721	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
648757007722	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
648757007723	Walker A/P-loop; other site
648757007724	ATP binding site [chemical binding]; other site
648757007725	Q-loop/lid; other site
648757007726	ABC transporter signature motif; other site
648757007727	Walker B; other site
648757007728	D-loop; other site
648757007729	H-loop/switch region; other site
648757007730	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
648757007731	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
648757007732	Walker A/P-loop; other site
648757007733	ATP binding site [chemical binding]; other site
648757007734	Q-loop/lid; other site
648757007735	ABC transporter signature motif; other site
648757007736	Walker B; other site
648757007737	D-loop; other site
648757007738	H-loop/switch region; other site
648757007739	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
648757007740	non-specific DNA binding site [nucleotide binding]; other site
648757007741	salt bridge; other site
648757007742	sequence-specific DNA binding site [nucleotide binding]; other site
648757007743	crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246
648757007744	crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751
648757007745	putative NAD(P) binding site [chemical binding]; other site
648757007746	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
648757007747	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
648757007748	active site
648757007749	Putative ParB-like nuclease; Region: ParBc_2; pfam08857
648757007750	aromatic amino acid exporter; Provisional; Region: PRK11689
648757007751	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
648757007752	catalytic core [active]
648757007753	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
648757007754	Ligand binding site; other site
648757007755	oligomer interface; other site
648757007756	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
648757007757	classical (c) SDRs; Region: SDR_c; cd05233
648757007758	NAD(P) binding site [chemical binding]; other site
648757007759	active site
648757007760	Protein of unknown function (DUF1345); Region: DUF1345; cl01753
648757007761	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
648757007762	active site
648757007763	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
648757007764	S17 interaction site [polypeptide binding]; other site
648757007765	S8 interaction site; other site
648757007766	16S rRNA interaction site [nucleotide binding]; other site
648757007767	streptomycin interaction site [chemical binding]; other site
648757007768	23S rRNA interaction site [nucleotide binding]; other site
648757007769	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
648757007770	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
648757007771	elongation factor G; Reviewed; Region: PRK00007
648757007772	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
648757007773	G1 box; other site
648757007774	putative GEF interaction site [polypeptide binding]; other site
648757007775	GTP/Mg2+ binding site [chemical binding]; other site
648757007776	Switch I region; other site
648757007777	G2 box; other site
648757007778	G3 box; other site
648757007779	Switch II region; other site
648757007780	G4 box; other site
648757007781	G5 box; other site
648757007782	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
648757007783	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
648757007784	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
648757007785	elongation factor Tu; Reviewed; Region: PRK00049
648757007786	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
648757007787	G1 box; other site
648757007788	GEF interaction site [polypeptide binding]; other site
648757007789	GTP/Mg2+ binding site [chemical binding]; other site
648757007790	Switch I region; other site
648757007791	G2 box; other site
648757007792	G3 box; other site
648757007793	Switch II region; other site
648757007794	G4 box; other site
648757007795	G5 box; other site
648757007796	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
648757007797	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
648757007798	Antibiotic Binding Site [chemical binding]; other site
648757007799	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
648757007800	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
648757007801	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
648757007802	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
648757007803	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
648757007804	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
648757007805	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
648757007806	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
648757007807	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
648757007808	putative translocon binding site; other site
648757007809	protein-rRNA interface [nucleotide binding]; other site
648757007810	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
648757007811	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
648757007812	G-X-X-G motif; other site
648757007813	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
648757007814	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
648757007815	23S rRNA interface [nucleotide binding]; other site
648757007816	5S rRNA interface [nucleotide binding]; other site
648757007817	putative antibiotic binding site [chemical binding]; other site
648757007818	L25 interface [polypeptide binding]; other site
648757007819	L27 interface [polypeptide binding]; other site
648757007820	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
648757007821	putative translocon interaction site; other site
648757007822	23S rRNA interface [nucleotide binding]; other site
648757007823	signal recognition particle (SRP54) interaction site; other site
648757007824	L23 interface [polypeptide binding]; other site
648757007825	trigger factor interaction site; other site
648757007826	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
648757007827	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
648757007828	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
648757007829	KOW motif; Region: KOW; cl00354
648757007830	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
648757007831	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
648757007832	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
648757007833	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
648757007834	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
648757007835	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
648757007836	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
648757007837	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
648757007838	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
648757007839	5S rRNA interface [nucleotide binding]; other site
648757007840	23S rRNA interface [nucleotide binding]; other site
648757007841	L5 interface [polypeptide binding]; other site
648757007842	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
648757007843	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
648757007844	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
648757007845	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
648757007846	23S rRNA binding site [nucleotide binding]; other site
648757007847	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
648757007848	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
648757007849	SecY translocase; Region: SecY; pfam00344
648757007850	adenylate kinase; Reviewed; Region: adk; PRK00279
648757007851	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
648757007852	AMP-binding site [chemical binding]; other site
648757007853	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
648757007854	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
648757007855	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
648757007856	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
648757007857	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
648757007858	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
648757007859	alphaNTD - beta interaction site [polypeptide binding]; other site
648757007860	alphaNTD homodimer interface [polypeptide binding]; other site
648757007861	alphaNTD - beta' interaction site [polypeptide binding]; other site
648757007862	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
648757007863	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
648757007864	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
648757007865	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757007866	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
648757007867	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
648757007868	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
648757007869	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
648757007870	Iron-sulfur protein interface; other site
648757007871	proximal heme binding site [chemical binding]; other site
648757007872	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
648757007873	Iron-sulfur protein interface; other site
648757007874	proximal quinone binding site [chemical binding]; other site
648757007875	C-subunit interface; other site
648757007876	distal quinone binding site; other site
648757007877	Domain of unknown function DUF59; Region: DUF59; cl00941
648757007878	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
648757007879	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
648757007880	Walker A motif; other site
648757007881	Stringent starvation protein B; Region: SspB; cl01120
648757007882	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
648757007883	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
648757007884	LytB protein; Region: LYTB; cl00507
648757007885	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
648757007886	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
648757007887	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
648757007888	FeS/SAM binding site; other site
648757007889	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
648757007890	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
648757007891	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
648757007892	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
648757007893	Active site cavity [active]
648757007894	catalytic acid [active]
648757007895	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757007896	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
648757007897	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
648757007898	active site lid residues [active]
648757007899	substrate binding pocket [chemical binding]; other site
648757007900	catalytic residues [active]
648757007901	substrate-Mg2+ binding site; other site
648757007902	aspartate-rich region 1; other site
648757007903	aspartate-rich region 2; other site
648757007904	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
648757007905	active site lid residues [active]
648757007906	substrate binding pocket [chemical binding]; other site
648757007907	catalytic residues [active]
648757007908	substrate-Mg2+ binding site; other site
648757007909	aspartate-rich region 1; other site
648757007910	aspartate-rich region 2; other site
648757007911	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
648757007912	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
648757007913	active site
648757007914	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
648757007915	GTP-binding protein LepA; Provisional; Region: PRK05433
648757007916	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
648757007917	G1 box; other site
648757007918	putative GEF interaction site [polypeptide binding]; other site
648757007919	GTP/Mg2+ binding site [chemical binding]; other site
648757007920	Switch I region; other site
648757007921	G2 box; other site
648757007922	G3 box; other site
648757007923	Switch II region; other site
648757007924	G4 box; other site
648757007925	G5 box; other site
648757007926	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
648757007927	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
648757007928	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
648757007929	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
648757007930	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673
648757007931	motif 1; other site
648757007932	active site
648757007933	motif 2; other site
648757007934	motif 3; other site
648757007935	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
648757007936	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
648757007937	protein RecA; Region: tigrfam_recA; TIGR02012
648757007938	hexamer interface [polypeptide binding]; other site
648757007939	Walker A motif; other site
648757007940	ATP binding site [chemical binding]; other site
648757007941	Walker B motif; other site
648757007942	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
648757007943	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
648757007944	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
648757007945	dimer interface [polypeptide binding]; other site
648757007946	phosphorylation site [posttranslational modification]
648757007947	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757007948	ATP binding site [chemical binding]; other site
648757007949	Mg2+ binding site [ion binding]; other site
648757007950	G-X-G motif; other site
648757007951	Response regulator receiver domain; Region: Response_reg; pfam00072
648757007952	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757007953	active site
648757007954	phosphorylation site [posttranslational modification]
648757007955	intermolecular recognition site; other site
648757007956	dimerization interface [polypeptide binding]; other site
648757007957	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
648757007958	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
648757007959	Walker A/P-loop; other site
648757007960	ATP binding site [chemical binding]; other site
648757007961	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
648757007962	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
648757007963	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
648757007964	ABC transporter signature motif; other site
648757007965	Walker B; other site
648757007966	D-loop; other site
648757007967	H-loop/switch region; other site
648757007968	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
648757007969	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
648757007970	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
648757007971	Protein of unknown function (DUF721); Region: DUF721; cl02324
648757007972	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
648757007973	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
648757007974	minor groove reading motif; other site
648757007975	helix-hairpin-helix signature motif; other site
648757007976	substrate binding pocket [chemical binding]; other site
648757007977	active site
648757007978	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
648757007979	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
648757007980	DNA binding and oxoG recognition site [nucleotide binding]
648757007981	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
648757007982	putative catalytic residue [active]
648757007983	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
648757007984	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
648757007985	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
648757007986	DsbD alpha interface [polypeptide binding]; other site
648757007987	catalytic residues [active]
648757007988	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
648757007989	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433
648757007990	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
648757007991	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433
648757007992	Membrane glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: MdoH; COG2943
648757007993	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
648757007994	Ligand binding site; other site
648757007995	DXD motif; other site
648757007996	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
648757007997	ligand binding site [chemical binding]; other site
648757007998	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
648757007999	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
648757008000	Isochorismatase family; Region: Isochorismatase; pfam00857
648757008001	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
648757008002	catalytic triad [active]
648757008003	conserved cis-peptide bond; other site
648757008004	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
648757008005	putative active site [active]
648757008006	putative metal binding residues [ion binding]; other site
648757008007	signature motif; other site
648757008008	putative dimer interface [polypeptide binding]; other site
648757008009	putative phosphate binding site [ion binding]; other site
648757008010	SpoVR family protein; Provisional; Region: PRK11767
648757008011	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
648757008012	Uncharacterized conserved protein [Function unknown]; Region: COG2718
648757008013	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
648757008014	PrkA family serine protein kinase; Provisional; Region: PRK15455
648757008015	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757008016	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
648757008017	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
648757008018	DNA-binding site [nucleotide binding]; DNA binding site
648757008019	RNA-binding motif; other site
648757008020	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; cl01353
648757008021	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
648757008022	aromatic arch; other site
648757008023	DCoH dimer interaction site [polypeptide binding]; other site
648757008024	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
648757008025	DCoH tetramer interaction site [polypeptide binding]; other site
648757008026	substrate binding site [chemical binding]; other site
648757008027	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
648757008028	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
648757008029	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757008030	homodimer interface [polypeptide binding]; other site
648757008031	catalytic residue [active]
648757008032	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
648757008033	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757008034	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
648757008035	putative active site pocket [active]
648757008036	dimerization interface [polypeptide binding]; other site
648757008037	putative catalytic residue [active]
648757008038	Helix-turn-helix domains; Region: HTH; cl00088
648757008039	Oligomerisation domain; Region: Oligomerisation; cl00519
648757008040	Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679
648757008041	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590
648757008042	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
648757008043	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
648757008044	putative ADP-binding pocket [chemical binding]; other site
648757008045	ferric uptake regulator; Provisional; Region: fur; PRK09462
648757008046	Helix-turn-helix domains; Region: HTH; cl00088
648757008047	metal binding site 2 [ion binding]; metal-binding site
648757008048	putative DNA binding helix; other site
648757008049	metal binding site 1 [ion binding]; metal-binding site
648757008050	dimer interface [polypeptide binding]; other site
648757008051	structural Zn2+ binding site [ion binding]; other site
648757008052	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
648757008053	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757008054	Walker A/P-loop; other site
648757008055	ATP binding site [chemical binding]; other site
648757008056	Q-loop/lid; other site
648757008057	ABC transporter signature motif; other site
648757008058	Walker B; other site
648757008059	D-loop; other site
648757008060	H-loop/switch region; other site
648757008061	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
648757008062	dimer interface [polypeptide binding]; other site
648757008063	putative PBP binding regions; other site
648757008064	ABC-ATPase subunit  interface; other site
648757008065	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
648757008066	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
648757008067	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
648757008068	Helix-turn-helix domains; Region: HTH; cl00088
648757008069	Winged helix-turn helix; Region: HTH_29; pfam13551
648757008070	Helix-turn-helix domains; Region: HTH; cl00088
648757008071	Integrase core domain; Region: rve; cl01316
648757008072	Helix-turn-helix domains; Region: HTH; cl00088
648757008073	Winged helix-turn helix; Region: HTH_29; pfam13551
648757008074	Integrase core domain; Region: rve; cl01316
648757008075	DDE domain; Region: DDE_Tnp_IS240; pfam13610
648757008076	Integrase core domain; Region: rve_3; cl15866
648757008077	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
648757008078	RNA binding site [nucleotide binding]; other site
648757008079	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
648757008080	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
648757008081	AMIN domain; Region: AMIN; pfam11741
648757008082	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
648757008083	active site
648757008084	metal binding site [ion binding]; metal-binding site
648757008085	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
648757008086	Transglycosylase; Region: Transgly; cl07896
648757008087	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
648757008088	peptide chain release factor 2; Validated; Region: prfB; PRK00578
648757008089	RF-1 domain; Region: RF-1; cl02875
648757008090	RF-1 domain; Region: RF-1; cl02875
648757008091	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
648757008092	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
648757008093	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
648757008094	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
648757008095	active site
648757008096	dimer interface [polypeptide binding]; other site
648757008097	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
648757008098	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
648757008099	active site
648757008100	enoyl-CoA hydratase; Provisional; Region: PRK05995
648757008101	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
648757008102	substrate binding site [chemical binding]; other site
648757008103	oxyanion hole (OAH) forming residues; other site
648757008104	trimer interface [polypeptide binding]; other site
648757008105	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
648757008106	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
648757008107	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
648757008108	active site
648757008109	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
648757008110	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
648757008111	S-adenosylmethionine binding site [chemical binding]; other site
648757008112	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
648757008113	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
648757008114	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
648757008115	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
648757008116	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
648757008117	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
648757008118	HIT family signature motif; other site
648757008119	catalytic residue [active]
648757008120	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
648757008121	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
648757008122	Coenzyme A binding pocket [chemical binding]; other site
648757008123	primosome assembly protein PriA; Validated; Region: PRK05580
648757008124	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
648757008125	ATP binding site [chemical binding]; other site
648757008126	putative Mg++ binding site [ion binding]; other site
648757008127	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757008128	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
648757008129	DNA-binding site [nucleotide binding]; DNA binding site
648757008130	RNA-binding motif; other site
648757008131	Helix-turn-helix domains; Region: HTH; cl00088
648757008132	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
648757008133	Amidinotransferase; Region: Amidinotransf; cl12043
648757008134	ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854
648757008135	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
648757008136	inhibitor-cofactor binding pocket; inhibition site
648757008137	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757008138	catalytic residue [active]
648757008139	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
648757008140	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
648757008141	substrate binding site; other site
648757008142	tetramer interface; other site
648757008143	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
648757008144	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
648757008145	NADP binding site [chemical binding]; other site
648757008146	active site
648757008147	putative substrate binding site [chemical binding]; other site
648757008148	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
648757008149	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
648757008150	NAD binding site [chemical binding]; other site
648757008151	substrate binding site [chemical binding]; other site
648757008152	homodimer interface [polypeptide binding]; other site
648757008153	active site
648757008154	Cupin domain; Region: Cupin_2; cl09118
648757008155	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
648757008156	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
648757008157	LamB/YcsF family; Region: LamB_YcsF; cl00664
648757008158	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
648757008159	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
648757008160	inhibitor-cofactor binding pocket; inhibition site
648757008161	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757008162	catalytic residue [active]
648757008163	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
648757008164	S-adenosylmethionine binding site [chemical binding]; other site
648757008165	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
648757008166	nucleoside/Zn binding site; other site
648757008167	dimer interface [polypeptide binding]; other site
648757008168	catalytic motif [active]
648757008169	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
648757008170	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
648757008171	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
648757008172	protein binding site [polypeptide binding]; other site
648757008173	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
648757008174	protein binding site [polypeptide binding]; other site
648757008175	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
648757008176	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757008177	active site
648757008178	phosphorylation site [posttranslational modification]
648757008179	intermolecular recognition site; other site
648757008180	dimerization interface [polypeptide binding]; other site
648757008181	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
648757008182	DNA binding site [nucleotide binding]
648757008183	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
648757008184	dimerization interface [polypeptide binding]; other site
648757008185	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
648757008186	dimer interface [polypeptide binding]; other site
648757008187	phosphorylation site [posttranslational modification]
648757008188	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757008189	ATP binding site [chemical binding]; other site
648757008190	Mg2+ binding site [ion binding]; other site
648757008191	G-X-G motif; other site
648757008192	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
648757008193	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
648757008194	metal binding triad; other site
648757008195	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
648757008196	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
648757008197	metal binding triad; other site
648757008198	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
648757008199	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
648757008200	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
648757008201	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
648757008202	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
648757008203	putative active site [active]
648757008204	Dehydratase family; Region: ILVD_EDD; cl00340
648757008205	6-phosphogluconate dehydratase; Region: edd; TIGR01196
648757008206	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
648757008207	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
648757008208	active site
648757008209	intersubunit interface [polypeptide binding]; other site
648757008210	catalytic residue [active]
648757008211	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
648757008212	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
648757008213	active site
648757008214	dimer interface [polypeptide binding]; other site
648757008215	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
648757008216	Ligand Binding Site [chemical binding]; other site
648757008217	Molecular Tunnel; other site
648757008218	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
648757008219	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757008220	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
648757008221	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
648757008222	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
648757008223	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
648757008224	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
648757008225	putative ADP-binding pocket [chemical binding]; other site
648757008226	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
648757008227	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
648757008228	trimer interface [polypeptide binding]; other site
648757008229	active site
648757008230	substrate binding site [chemical binding]; other site
648757008231	CoA binding site [chemical binding]; other site
648757008232	Protein of unknown function (DUF805); Region: DUF805; cl01224
648757008233	Protein of unknown function (DUF805); Region: DUF805; cl01224
648757008234	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
648757008235	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
648757008236	metal binding site [ion binding]; metal-binding site
648757008237	dimer interface [polypeptide binding]; other site
648757008238	integrase; Provisional; Region: PRK09692
648757008239	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
648757008240	active site
648757008241	Int/Topo IB signature motif; other site
648757008242	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
648757008243	type IV secretion system component VirD4; Provisional; Region: PRK13897
648757008244	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
648757008245	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
648757008246	Phospholipid methyltransferase; Region: PEMT; cl00763
648757008247	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
648757008248	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
648757008249	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
648757008250	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
648757008251	Sodium:solute symporter family; Region: SSF; cl00456
648757008252	Domain of unknown function (DUF4212); Region: DUF4212; cl01781
648757008253	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
648757008254	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757008255	active site
648757008256	phosphorylation site [posttranslational modification]
648757008257	intermolecular recognition site; other site
648757008258	dimerization interface [polypeptide binding]; other site
648757008259	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
648757008260	DNA binding residues [nucleotide binding]
648757008261	dimerization interface [polypeptide binding]; other site
648757008262	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
648757008263	putative active site [active]
648757008264	putative metal binding site [ion binding]; other site
648757008265	Helix-turn-helix domains; Region: HTH; cl00088
648757008266	Winged helix-turn helix; Region: HTH_29; pfam13551
648757008267	Helix-turn-helix domains; Region: HTH; cl00088
648757008268	Integrase core domain; Region: rve; cl01316
648757008269	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
648757008270	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
648757008271	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
648757008272	DNA binding site [nucleotide binding]
648757008273	Int/Topo IB signature motif; other site
648757008274	active site
648757008275	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
648757008276	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
648757008277	catalytic residues [active]
648757008278	catalytic nucleophile [active]
648757008279	Presynaptic Site I dimer interface [polypeptide binding]; other site
648757008280	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
648757008281	Synaptic Flat tetramer interface [polypeptide binding]; other site
648757008282	Synaptic Site I dimer interface [polypeptide binding]; other site
648757008283	DNA binding site [nucleotide binding]
648757008284	Helix-turn-helix domains; Region: HTH; cl00088
648757008285	DNA-binding interface [nucleotide binding]; DNA binding site
648757008286	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
648757008287	DEAD-like helicases superfamily; Region: DEXDc; smart00487
648757008288	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
648757008289	ATP binding site [chemical binding]; other site
648757008290	putative Mg++ binding site [ion binding]; other site
648757008291	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757008292	nucleotide binding region [chemical binding]; other site
648757008293	ATP-binding site [chemical binding]; other site
648757008294	EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463
648757008295	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
648757008296	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
648757008297	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
648757008298	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757008299	ParB-like nuclease domain; Region: ParBc; cl02129
648757008300	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
648757008301	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
648757008302	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
648757008303	putative DNA binding site [nucleotide binding]; other site
648757008304	putative Zn2+ binding site [ion binding]; other site
648757008305	Helix-turn-helix domains; Region: HTH; cl00088
648757008306	methionine gamma-lyase; Provisional; Region: PRK07503
648757008307	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
648757008308	homodimer interface [polypeptide binding]; other site
648757008309	substrate-cofactor binding pocket; other site
648757008310	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757008311	catalytic residue [active]
648757008312	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
648757008313	Helix-turn-helix domains; Region: HTH; cl00088
648757008314	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
648757008315	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
648757008316	non-specific DNA binding site [nucleotide binding]; other site
648757008317	salt bridge; other site
648757008318	sequence-specific DNA binding site [nucleotide binding]; other site
648757008319	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
648757008320	TIR domain; Region: TIR_2; cl15770
648757008321	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
648757008322	additional DNA contacts [nucleotide binding]; other site
648757008323	mismatch recognition site; other site
648757008324	active site
648757008325	zinc binding site [ion binding]; other site
648757008326	DNA intercalation site [nucleotide binding]; other site
648757008327	Helix-turn-helix domains; Region: HTH; cl00088
648757008328	Winged helix-turn helix; Region: HTH_29; pfam13551
648757008329	Integrase core domain; Region: rve; cl01316
648757008330	DDE domain; Region: DDE_Tnp_IS240; pfam13610
648757008331	Integrase core domain; Region: rve_3; cl15866
648757008332	Transposase domain (DUF772); Region: DUF772; cl15789
648757008333	Transposase domain (DUF772); Region: DUF772; cl15789
648757008334	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
648757008335	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
648757008336	ligand binding site; other site
648757008337	Protein of unknown function (DUF3644); Region: DUF3644; pfam12358
648757008338	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
648757008339	Mrr N-terminal domain; Region: Mrr_N; pfam14338
648757008340	Restriction endonuclease; Region: Mrr_cat; cl00516
648757008341	Helix-turn-helix domains; Region: HTH; cl00088
648757008342	Winged helix-turn helix; Region: HTH_29; pfam13551
648757008343	Helix-turn-helix domains; Region: HTH; cl00088
648757008344	Integrase core domain; Region: rve; cl01316
648757008345	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
648757008346	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
648757008347	active site
648757008348	NTP binding site [chemical binding]; other site
648757008349	nucleic acid binding site [nucleotide binding]; other site
648757008350	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
648757008351	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
648757008352	Integrase core domain; Region: rve; cl01316
648757008353	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
648757008354	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
648757008355	Helix-turn-helix domains; Region: HTH; cl00088
648757008356	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
648757008357	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
648757008358	Transcriptional regulator [Transcription]; Region: LysR; COG0583
648757008359	Helix-turn-helix domains; Region: HTH; cl00088
648757008360	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
648757008361	dimerization interface [polypeptide binding]; other site
648757008362	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
648757008363	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
648757008364	Int/Topo IB signature motif; other site
648757008365	DNA binding site [nucleotide binding]
648757008366	active site
648757008367	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
648757008368	Int/Topo IB signature motif; other site
648757008369	active site
648757008370	DNA binding site [nucleotide binding]
648757008371	DNA polymerase I; Provisional; Region: PRK05755
648757008372	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
648757008373	active site
648757008374	metal binding site 1 [ion binding]; metal-binding site
648757008375	putative 5' ssDNA interaction site; other site
648757008376	metal binding site 3; metal-binding site
648757008377	metal binding site 2 [ion binding]; metal-binding site
648757008378	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
648757008379	putative DNA binding site [nucleotide binding]; other site
648757008380	putative metal binding site [ion binding]; other site
648757008381	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
648757008382	active site
648757008383	catalytic site [active]
648757008384	substrate binding site [chemical binding]; other site
648757008385	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
648757008386	active site
648757008387	DNA binding site [nucleotide binding]
648757008388	catalytic site [active]
648757008389	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
648757008390	Protein of unknown function (DUF1465); Region: DUF1465; cl11562
648757008391	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
648757008392	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
648757008393	NAD(P) binding site [chemical binding]; other site
648757008394	ribosome maturation protein RimP; Reviewed; Region: PRK00092
648757008395	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
648757008396	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
648757008397	Sm1 motif; other site
648757008398	D3 - B interaction site; other site
648757008399	D1 - D2 interaction site; other site
648757008400	Hfq - Hfq interaction site; other site
648757008401	RNA binding pocket [nucleotide binding]; other site
648757008402	Sm2 motif; other site
648757008403	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
648757008404	NusA N-terminal domain; Region: NusA_N; pfam08529
648757008405	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
648757008406	RNA binding site [nucleotide binding]; other site
648757008407	homodimer interface [polypeptide binding]; other site
648757008408	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
648757008409	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
648757008410	G-X-X-G motif; other site
648757008411	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
648757008412	hypothetical protein; Provisional; Region: PRK09190
648757008413	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
648757008414	putative RNA binding cleft [nucleotide binding]; other site
648757008415	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
648757008416	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
648757008417	translation initiation factor IF-2; Region: IF-2; TIGR00487
648757008418	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
648757008419	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
648757008420	G1 box; other site
648757008421	putative GEF interaction site [polypeptide binding]; other site
648757008422	GTP/Mg2+ binding site [chemical binding]; other site
648757008423	Switch I region; other site
648757008424	G2 box; other site
648757008425	G3 box; other site
648757008426	Switch II region; other site
648757008427	G4 box; other site
648757008428	G5 box; other site
648757008429	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
648757008430	Translation-initiation factor 2; Region: IF-2; pfam11987
648757008431	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
648757008432	Uncharacterized protein conserved in bacteria (DUF2093); Region: DUF2093; cl11535
648757008433	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
648757008434	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
648757008435	generic binding surface II; other site
648757008436	generic binding surface I; other site
648757008437	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
648757008438	Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137
648757008439	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
648757008440	ANP binding site [chemical binding]; other site
648757008441	Substrate Binding Site II [chemical binding]; other site
648757008442	Substrate Binding Site I [chemical binding]; other site
648757008443	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
648757008444	dimer interface [polypeptide binding]; other site
648757008445	Citrate synthase; Region: Citrate_synt; pfam00285
648757008446	active site
648757008447	citrylCoA binding site [chemical binding]; other site
648757008448	NADH binding [chemical binding]; other site
648757008449	cationic pore residues; other site
648757008450	oxalacetate/citrate binding site [chemical binding]; other site
648757008451	coenzyme A binding site [chemical binding]; other site
648757008452	catalytic triad [active]
648757008453	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
648757008454	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
648757008455	dimer interface [polypeptide binding]; other site
648757008456	conserved gate region; other site
648757008457	putative PBP binding loops; other site
648757008458	ABC-ATPase subunit interface; other site
648757008459	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
648757008460	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
648757008461	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
648757008462	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
648757008463	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
648757008464	substrate binding pocket [chemical binding]; other site
648757008465	membrane-bound complex binding site; other site
648757008466	hinge residues; other site
648757008467	cystathionine beta-lyase; Provisional; Region: PRK05967
648757008468	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
648757008469	homodimer interface [polypeptide binding]; other site
648757008470	substrate-cofactor binding pocket; other site
648757008471	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757008472	catalytic residue [active]
648757008473	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
648757008474	DHH family; Region: DHH; pfam01368
648757008475	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
648757008476	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439
648757008477	heme-binding residues [chemical binding]; other site
648757008478	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
648757008479	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
648757008480	Protein of unknown function (DUF3374); Region: DUF3374; cl11904
648757008481	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
648757008482	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
648757008483	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
648757008484	binding surface
648757008485	TPR motif; other site
648757008486	CcmE; Region: CcmE; cl00994
648757008487	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
648757008488	Cytochrome C biogenesis protein; Region: CcmH; cl01179
648757008489	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
648757008490	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
648757008491	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
648757008492	putative ADP-binding pocket [chemical binding]; other site
648757008493	tartrate dehydrogenase; Provisional; Region: PRK08194
648757008494	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
648757008495	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270
648757008496	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
648757008497	putative active site [active]
648757008498	Helix-turn-helix domains; Region: HTH; cl00088
648757008499	Winged helix-turn helix; Region: HTH_29; pfam13551
648757008500	Integrase core domain; Region: rve; cl01316
648757008501	DDE domain; Region: DDE_Tnp_IS240; pfam13610
648757008502	Integrase core domain; Region: rve_3; cl15866
648757008503	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
648757008504	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
648757008505	active site
648757008506	HIGH motif; other site
648757008507	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
648757008508	active site
648757008509	KMSKS motif; other site
648757008510	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
648757008511	Competence protein; Region: Competence; cl00471
648757008512	aminotransferase; Validated; Region: PRK09148
648757008513	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
648757008514	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757008515	homodimer interface [polypeptide binding]; other site
648757008516	catalytic residue [active]
648757008517	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
648757008518	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
648757008519	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
648757008520	catalytic residue [active]
648757008521	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
648757008522	CoenzymeA binding site [chemical binding]; other site
648757008523	subunit interaction site [polypeptide binding]; other site
648757008524	PHB binding site; other site
648757008525	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
648757008526	23S rRNA interface [nucleotide binding]; other site
648757008527	L3 interface [polypeptide binding]; other site
648757008528	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
648757008529	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
648757008530	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757008531	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
648757008532	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
648757008533	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
648757008534	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
648757008535	Cysteine-rich domain; Region: CCG; pfam02754
648757008536	Cysteine-rich domain; Region: CCG; pfam02754
648757008537	FAD binding domain; Region: FAD_binding_4; pfam01565
648757008538	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
648757008539	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
648757008540	FAD binding domain; Region: FAD_binding_4; pfam01565
648757008541	Helix-turn-helix domains; Region: HTH; cl00088
648757008542	transcriptional activator TtdR; Provisional; Region: PRK09801
648757008543	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
648757008544	putative effector binding pocket; other site
648757008545	dimerization interface [polypeptide binding]; other site
648757008546	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
648757008547	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
648757008548	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
648757008549	DctM-like transporters; Region: DctM; pfam06808
648757008550	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
648757008551	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
648757008552	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
648757008553	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
648757008554	Catalytic site [active]
648757008555	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
648757008556	ribonuclease III; Reviewed; Region: rnc; PRK00102
648757008557	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
648757008558	dimerization interface [polypeptide binding]; other site
648757008559	active site
648757008560	metal binding site [ion binding]; metal-binding site
648757008561	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
648757008562	dsRNA binding site [nucleotide binding]; other site
648757008563	GTPase Era; Reviewed; Region: era; PRK00089
648757008564	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
648757008565	G1 box; other site
648757008566	GTP/Mg2+ binding site [chemical binding]; other site
648757008567	Switch I region; other site
648757008568	G2 box; other site
648757008569	Switch II region; other site
648757008570	G3 box; other site
648757008571	G4 box; other site
648757008572	G5 box; other site
648757008573	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
648757008574	Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381
648757008575	Recombination protein O N terminal; Region: RecO_N; cl15812
648757008576	Recombination protein O C terminal; Region: RecO_C; pfam02565
648757008577	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
648757008578	TPR repeat; Region: TPR_11; pfam13414
648757008579	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
648757008580	binding surface
648757008581	TPR motif; other site
648757008582	TPR repeat; Region: TPR_11; pfam13414
648757008583	Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659
648757008584	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
648757008585	2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559
648757008586	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
648757008587	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
648757008588	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
648757008589	dimer interface [polypeptide binding]; other site
648757008590	phosphorylation site [posttranslational modification]
648757008591	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757008592	ATP binding site [chemical binding]; other site
648757008593	Mg2+ binding site [ion binding]; other site
648757008594	G-X-G motif; other site
648757008595	GAF domain; Region: GAF; cl15785
648757008596	GAF domain; Region: GAF_2; pfam13185
648757008597	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
648757008598	dimer interface [polypeptide binding]; other site
648757008599	phosphorylation site [posttranslational modification]
648757008600	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757008601	ATP binding site [chemical binding]; other site
648757008602	Mg2+ binding site [ion binding]; other site
648757008603	G-X-G motif; other site
648757008604	Response regulator receiver domain; Region: Response_reg; pfam00072
648757008605	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757008606	active site
648757008607	phosphorylation site [posttranslational modification]
648757008608	intermolecular recognition site; other site
648757008609	dimerization interface [polypeptide binding]; other site
648757008610	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
648757008611	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
648757008612	catalytic triad [active]
648757008613	dimer interface [polypeptide binding]; other site
648757008614	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
648757008615	GDP/GTP exchange factor Sec2p; Region: Sec2p; pfam06428
648757008616	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
648757008617	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
648757008618	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
648757008619	protein binding site [polypeptide binding]; other site
648757008620	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
648757008621	Catalytic dyad [active]
648757008622	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
648757008623	putative active site [active]
648757008624	Ap4A binding site [chemical binding]; other site
648757008625	nudix motif; other site
648757008626	putative metal binding site [ion binding]; other site
648757008627	Plant ATP synthase F0; Region: YMF19; cl07975
648757008628	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
648757008629	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
648757008630	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
648757008631	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
648757008632	beta subunit interaction interface [polypeptide binding]; other site
648757008633	Walker A motif; other site
648757008634	ATP binding site [chemical binding]; other site
648757008635	Walker B motif; other site
648757008636	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
648757008637	ATP synthase; Region: ATP-synt; cl00365
648757008638	F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422
648757008639	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
648757008640	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
648757008641	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
648757008642	alpha subunit interaction interface [polypeptide binding]; other site
648757008643	Walker A motif; other site
648757008644	ATP binding site [chemical binding]; other site
648757008645	Walker B motif; other site
648757008646	inhibitor binding site; inhibition site
648757008647	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
648757008648	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
648757008649	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
648757008650	Helix-turn-helix domains; Region: HTH; cl00088
648757008651	Winged helix-turn helix; Region: HTH_29; pfam13551
648757008652	Integrase core domain; Region: rve; cl01316
648757008653	DDE domain; Region: DDE_Tnp_IS240; pfam13610
648757008654	Integrase core domain; Region: rve_3; cl15866
648757008655	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
648757008656	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
648757008657	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
648757008658	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757008659	active site
648757008660	phosphorylation site [posttranslational modification]
648757008661	intermolecular recognition site; other site
648757008662	dimerization interface [polypeptide binding]; other site
648757008663	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
648757008664	DNA binding site [nucleotide binding]
648757008665	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
648757008666	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
648757008667	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
648757008668	Ligand Binding Site [chemical binding]; other site
648757008669	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
648757008670	GAF domain; Region: GAF; cl15785
648757008671	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
648757008672	dimer interface [polypeptide binding]; other site
648757008673	phosphorylation site [posttranslational modification]
648757008674	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757008675	ATP binding site [chemical binding]; other site
648757008676	Mg2+ binding site [ion binding]; other site
648757008677	G-X-G motif; other site
648757008678	K+-transporting ATPase, c chain; Region: KdpC; cl00944
648757008679	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
648757008680	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
648757008681	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
648757008682	Potassium-transporting ATPase A subunit; Region: KdpA; cl00903
648757008683	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
648757008684	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
648757008685	Protein of unknown function (DUF502); Region: DUF502; cl01107
648757008686	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
648757008687	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
648757008688	metal binding site [ion binding]; metal-binding site
648757008689	putative dimer interface [polypeptide binding]; other site
648757008690	FtsH Extracellular; Region: FtsH_ext; pfam06480
648757008691	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
648757008692	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
648757008693	Walker A motif; other site
648757008694	ATP binding site [chemical binding]; other site
648757008695	Walker B motif; other site
648757008696	arginine finger; other site
648757008697	Peptidase family M41; Region: Peptidase_M41; pfam01434
648757008698	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
648757008699	Ligand Binding Site [chemical binding]; other site
648757008700	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
648757008701	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
648757008702	Tetratricopeptide repeat; Region: TPR_6; pfam13174
648757008703	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
648757008704	ligand binding site [chemical binding]; other site
648757008705	translocation protein TolB; Provisional; Region: tolB; PRK05137
648757008706	TolB amino-terminal domain; Region: TolB_N; cl00639
648757008707	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
648757008708	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
648757008709	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
648757008710	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
648757008711	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
648757008712	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
648757008713	AMP-binding enzyme; Region: AMP-binding; cl15778
648757008714	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
648757008715	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
648757008716	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
648757008717	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
648757008718	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
648757008719	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
648757008720	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
648757008721	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
648757008722	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
648757008723	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757008724	ATP binding site [chemical binding]; other site
648757008725	Mg2+ binding site [ion binding]; other site
648757008726	G-X-G motif; other site
648757008727	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
648757008728	anchoring element; other site
648757008729	dimer interface [polypeptide binding]; other site
648757008730	ATP binding site [chemical binding]; other site
648757008731	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
648757008732	active site
648757008733	putative metal-binding site [ion binding]; other site
648757008734	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
648757008735	Uncharacterized conserved protein [Function unknown]; Region: COG5323
648757008736	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
648757008737	P22 coat protein - gene protein 5; Region: P22_CoatProtein; cl10302
648757008738	GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547
648757008739	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
648757008740	enoyl-CoA hydratase; Provisional; Region: PRK06144
648757008741	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
648757008742	substrate binding site [chemical binding]; other site
648757008743	oxyanion hole (OAH) forming residues; other site
648757008744	trimer interface [polypeptide binding]; other site
648757008745	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
648757008746	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
648757008747	glucokinase, proteobacterial type; Region: glk; TIGR00749
648757008748	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
648757008749	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
648757008750	active site
648757008751	homotetramer interface [polypeptide binding]; other site
648757008752	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
648757008753	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
648757008754	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
648757008755	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
648757008756	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
648757008757	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
648757008758	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
648757008759	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
648757008760	IHF dimer interface [polypeptide binding]; other site
648757008761	IHF - DNA interface [nucleotide binding]; other site
648757008762	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
648757008763	dimer interface [polypeptide binding]; other site
648757008764	ssDNA binding site [nucleotide binding]; other site
648757008765	tetramer (dimer of dimers) interface [polypeptide binding]; other site
648757008766	DNA gyrase subunit A; Validated; Region: PRK05560
648757008767	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
648757008768	CAP-like domain; other site
648757008769	active site
648757008770	primary dimer interface [polypeptide binding]; other site
648757008771	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
648757008772	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
648757008773	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
648757008774	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
648757008775	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
648757008776	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
648757008777	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
648757008778	active site
648757008779	(T/H)XGH motif; other site
648757008780	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
648757008781	active site
648757008782	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
648757008783	active site
648757008784	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
648757008785	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
648757008786	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
648757008787	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
648757008788	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
648757008789	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
648757008790	NADH(P)-binding; Region: NAD_binding_10; pfam13460
648757008791	NAD binding site [chemical binding]; other site
648757008792	substrate binding site [chemical binding]; other site
648757008793	putative active site [active]
648757008794	Protein of unknown function (DUF1428); Region: DUF1428; cl02319
648757008795	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
648757008796	Helix-turn-helix domains; Region: HTH; cl00088
648757008797	Peptidase family M23; Region: Peptidase_M23; pfam01551
648757008798	TPR repeat; Region: TPR_11; pfam13414
648757008799	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
648757008800	binding surface
648757008801	TPR motif; other site
648757008802	TPR repeat; Region: TPR_11; pfam13414
648757008803	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
648757008804	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
648757008805	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
648757008806	AMP-binding enzyme; Region: AMP-binding; cl15778
648757008807	Phosphopantetheine attachment site; Region: PP-binding; cl09936
648757008808	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
648757008809	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
648757008810	putative trimer interface [polypeptide binding]; other site
648757008811	putative CoA binding site [chemical binding]; other site
648757008812	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
648757008813	putative trimer interface [polypeptide binding]; other site
648757008814	putative CoA binding site [chemical binding]; other site
648757008815	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
648757008816	putative trimer interface [polypeptide binding]; other site
648757008817	putative CoA binding site [chemical binding]; other site
648757008818	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
648757008819	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
648757008820	substrate binding site [chemical binding]; other site
648757008821	ligand binding site [chemical binding]; other site
648757008822	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
648757008823	putative active site pocket [active]
648757008824	dimerization interface [polypeptide binding]; other site
648757008825	putative catalytic residue [active]
648757008826	Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; pfam09582
648757008827	Fe-only nitrogenase accessory protein AnfO; Region: anfO_nitrog; TIGR02940
648757008828	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
648757008829	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
648757008830	Vanadium/alternative nitrogenase delta subunit; Region: AnfG_VnfG; cl03910
648757008831	nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284
648757008832	Nitrogenase_VFe_alpha -like: Nitrogenase VFe protein, alpha subunit like. This group contains proteins similar to the alpha subunits of,  the VFe protein of the vanadium-dependent (V-) nitrogenase and the FeFe protein of the iron only (Fe-) nitrogenase...; Region: Nitrogenase_VFe_alpha; cd01977
648757008833	nitrogenase reductase; Reviewed; Region: nifH; PRK13233
648757008834	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
648757008835	Nucleotide-binding sites [chemical binding]; other site
648757008836	Walker A motif; other site
648757008837	Switch I region of nucleotide binding site; other site
648757008838	Fe4S4 binding sites [ion binding]; other site
648757008839	Switch II region of nucleotide binding site; other site
648757008840	Nif-specific regulatory protein; Region: nifA; TIGR01817
648757008841	GAF domain; Region: GAF; cl15785
648757008842	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
648757008843	Walker A motif; other site
648757008844	ATP binding site [chemical binding]; other site
648757008845	Walker B motif; other site
648757008846	arginine finger; other site
648757008847	Helix-turn-helix domains; Region: HTH; cl00088
648757008848	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
648757008849	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
648757008850	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
648757008851	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
648757008852	DNA-binding site [nucleotide binding]; DNA binding site
648757008853	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
648757008854	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757008855	homodimer interface [polypeptide binding]; other site
648757008856	catalytic residue [active]
648757008857	Benzoate membrane transport protein; Region: BenE; pfam03594
648757008858	benzoate transporter; Region: benE; TIGR00843
648757008859	Methyltransferase domain; Region: Methyltransf_31; pfam13847
648757008860	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
648757008861	S-adenosylmethionine binding site [chemical binding]; other site
648757008862	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
648757008863	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
648757008864	Ligand Binding Site [chemical binding]; other site
648757008865	Sodium:solute symporter family; Region: SSF; cl00456
648757008866	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
648757008867	PAS fold; Region: PAS_7; pfam12860
648757008868	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
648757008869	dimer interface [polypeptide binding]; other site
648757008870	phosphorylation site [posttranslational modification]
648757008871	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757008872	ATP binding site [chemical binding]; other site
648757008873	Mg2+ binding site [ion binding]; other site
648757008874	G-X-G motif; other site
648757008875	Response regulator receiver domain; Region: Response_reg; pfam00072
648757008876	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757008877	active site
648757008878	phosphorylation site [posttranslational modification]
648757008879	intermolecular recognition site; other site
648757008880	dimerization interface [polypeptide binding]; other site
648757008881	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
648757008882	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
648757008883	Fe-S metabolism associated domain; Region: SufE; cl00951
648757008884	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
648757008885	recombination protein RecR; Reviewed; Region: recR; PRK00076
648757008886	RecR protein; Region: RecR; pfam02132
648757008887	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
648757008888	putative active site [active]
648757008889	putative metal-binding site [ion binding]; other site
648757008890	tetramer interface [polypeptide binding]; other site
648757008891	hypothetical protein; Validated; Region: PRK09039
648757008892	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
648757008893	ligand binding site [chemical binding]; other site
648757008894	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
648757008895	active site
648757008896	dimerization interface [polypeptide binding]; other site
648757008897	elongation factor P; Validated; Region: PRK00529
648757008898	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
648757008899	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
648757008900	RNA binding site [nucleotide binding]; other site
648757008901	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
648757008902	RNA binding site [nucleotide binding]; other site
648757008903	Predicted ATPase [General function prediction only]; Region: COG1485
648757008904	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
648757008905	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
648757008906	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
648757008907	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
648757008908	Walker A/P-loop; other site
648757008909	ATP binding site [chemical binding]; other site
648757008910	Q-loop/lid; other site
648757008911	ABC transporter signature motif; other site
648757008912	Walker B; other site
648757008913	D-loop; other site
648757008914	H-loop/switch region; other site
648757008915	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
648757008916	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
648757008917	putative active site [active]
648757008918	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
648757008919	putative acyl-acceptor binding pocket; other site
648757008920	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
648757008921	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
648757008922	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
648757008923	catalytic residue [active]
648757008924	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
648757008925	siroheme synthase; Provisional; Region: cysG; PRK10637
648757008926	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757008927	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757008928	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
648757008929	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
648757008930	CsbD-like; Region: CsbD; cl15799
648757008931	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
648757008932	O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504
648757008933	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
648757008934	homodimer interface [polypeptide binding]; other site
648757008935	substrate-cofactor binding pocket; other site
648757008936	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757008937	catalytic residue [active]
648757008938	MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245
648757008939	substrate binding site [chemical binding]; other site
648757008940	hypothetical protein; Validated; Region: PRK06886
648757008941	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
648757008942	active site
648757008943	LytB protein; Region: LYTB; cl00507
648757008944	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
648757008945	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
648757008946	Phosphotransferase enzyme family; Region: APH; pfam01636
648757008947	putative active site [active]
648757008948	putative substrate binding site [chemical binding]; other site
648757008949	ATP binding site [chemical binding]; other site
648757008950	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
648757008951	RNA/DNA hybrid binding site [nucleotide binding]; other site
648757008952	active site
648757008953	Helix-turn-helix domains; Region: HTH; cl00088
648757008954	Winged helix-turn helix; Region: HTH_29; pfam13551
648757008955	Integrase core domain; Region: rve; cl01316
648757008956	DDE domain; Region: DDE_Tnp_IS240; pfam13610
648757008957	Integrase core domain; Region: rve_3; cl15866
648757008958	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
648757008959	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
648757008960	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
648757008961	BON domain; Region: BON; cl02771
648757008962	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
648757008963	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
648757008964	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
648757008965	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
648757008966	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
648757008967	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
648757008968	NAD binding site [chemical binding]; other site
648757008969	homotetramer interface [polypeptide binding]; other site
648757008970	homodimer interface [polypeptide binding]; other site
648757008971	active site
648757008972	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
648757008973	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
648757008974	dimer interface [polypeptide binding]; other site
648757008975	active site
648757008976	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
648757008977	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
648757008978	FAD binding site [chemical binding]; other site
648757008979	homotetramer interface [polypeptide binding]; other site
648757008980	substrate binding pocket [chemical binding]; other site
648757008981	catalytic base [active]
648757008982	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
648757008983	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
648757008984	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
648757008985	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
648757008986	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
648757008987	tetrameric interface [polypeptide binding]; other site
648757008988	NAD binding site [chemical binding]; other site
648757008989	catalytic residues [active]
648757008990	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
648757008991	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
648757008992	active site
648757008993	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
648757008994	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
648757008995	substrate binding site [chemical binding]; other site
648757008996	oxyanion hole (OAH) forming residues; other site
648757008997	trimer interface [polypeptide binding]; other site
648757008998	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
648757008999	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757009000	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
648757009001	enoyl-CoA hydratase; Provisional; Region: PRK05862
648757009002	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
648757009003	substrate binding site [chemical binding]; other site
648757009004	oxyanion hole (OAH) forming residues; other site
648757009005	trimer interface [polypeptide binding]; other site
648757009006	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
648757009007	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
648757009008	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
648757009009	catalytic residue [active]
648757009010	Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; cl01970
648757009011	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
648757009012	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
648757009013	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
648757009014	ATP-grasp domain; Region: ATP-grasp_4; cl03087
648757009015	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
648757009016	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
648757009017	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
648757009018	carboxyltransferase (CT) interaction site; other site
648757009019	biotinylation site [posttranslational modification]; other site
648757009020	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
648757009021	trimer interface [polypeptide binding]; other site
648757009022	active site
648757009023	dimer interface [polypeptide binding]; other site
648757009024	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
648757009025	catalytic residues [active]
648757009026	Peptidase family M48; Region: Peptidase_M48; cl12018
648757009027	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
648757009028	TPR motif; other site
648757009029	Tetratricopeptide repeat; Region: TPR_16; pfam13432
648757009030	binding surface
648757009031	aspartate aminotransferase; Provisional; Region: PRK05764
648757009032	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
648757009033	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757009034	homodimer interface [polypeptide binding]; other site
648757009035	catalytic residue [active]
648757009036	Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839
648757009037	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
648757009038	putative catalytic cysteine [active]
648757009039	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
648757009040	ATP-grasp domain; Region: ATP-grasp_4; cl03087
648757009041	CoA-ligase; Region: Ligase_CoA; cl02894
648757009042	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757009043	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
648757009044	CoA-ligase; Region: Ligase_CoA; cl02894
648757009045	excinuclease ABC subunit B; Provisional; Region: PRK05298
648757009046	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
648757009047	ATP binding site [chemical binding]; other site
648757009048	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
648757009049	nucleotide binding region [chemical binding]; other site
648757009050	ATP-binding site [chemical binding]; other site
648757009051	Ultra-violet resistance protein B; Region: UvrB; pfam12344
648757009052	UvrB/uvrC motif; Region: UVR; pfam02151
648757009053	putative molybdenum utilization protein ModD; Region: modD; TIGR01334
648757009054	ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573
648757009055	dimerization interface [polypeptide binding]; other site
648757009056	active site
648757009057	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
648757009058	NifT/FixU protein; Region: NifT; cl02351
648757009059	NifZ domain; Region: NifZ; pfam04319
648757009060	NifZ domain; Region: NifZ; pfam04319
648757009061	LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484
648757009062	HEAT repeats; Region: HEAT_2; pfam13646
648757009063	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
648757009064	archaeoflavoprotein, MJ0208 family; Region: flavo_MJ0208; TIGR02700
648757009065	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
648757009066	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
648757009067	FeS/SAM binding site; other site
648757009068	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
648757009069	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
648757009070	AMP-binding enzyme; Region: AMP-binding; cl15778
648757009071	Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827
648757009072	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
648757009073	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
648757009074	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
648757009075	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
648757009076	carboxyltransferase (CT) interaction site; other site
648757009077	biotinylation site [posttranslational modification]; other site
648757009078	L-type amino acid transporter; Region: 2A0308; TIGR00911
648757009079	Spore germination protein; Region: Spore_permease; cl15802
648757009080	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
648757009081	RNA polymerase sigma factor; Reviewed; Region: PRK05602
648757009082	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
648757009083	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
648757009084	DNA binding residues [nucleotide binding]
648757009085	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
648757009086	HrcA protein C terminal domain; Region: HrcA; pfam01628
648757009087	heat shock protein GrpE; Provisional; Region: PRK14141
648757009088	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
648757009089	dimer interface [polypeptide binding]; other site
648757009090	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
648757009091	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
648757009092	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
648757009093	putative active site [active]
648757009094	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
648757009095	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
648757009096	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
648757009097	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
648757009098	dimer interface [polypeptide binding]; other site
648757009099	active site
648757009100	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
648757009101	dimer interface [polypeptide binding]; other site
648757009102	active site
648757009103	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
648757009104	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
648757009105	active site
648757009106	dimer interface [polypeptide binding]; other site
648757009107	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
648757009108	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
648757009109	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
648757009110	catalytic residue [active]
648757009111	biotin synthase; Region: bioB; TIGR00433
648757009112	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
648757009113	FeS/SAM binding site; other site
648757009114	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
648757009115	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
648757009116	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
648757009117	dimer interface [polypeptide binding]; other site
648757009118	phosphorylation site [posttranslational modification]
648757009119	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757009120	ATP binding site [chemical binding]; other site
648757009121	Mg2+ binding site [ion binding]; other site
648757009122	G-X-G motif; other site
648757009123	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
648757009124	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
648757009125	DNA binding residues [nucleotide binding]
648757009126	dimerization interface [polypeptide binding]; other site
648757009127	Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154
648757009128	Rab subfamily motif 1 (RabSF1); other site
648757009129	G1 box; other site
648757009130	GTP/Mg2+ binding site [chemical binding]; other site
648757009131	Rab subfamily motif 2 (RabSF2); other site
648757009132	Switch I region; other site
648757009133	G2 box; other site
648757009134	effector interaction site; other site
648757009135	GDI interaction site; other site
648757009136	Rab family motif 1 (RabF1); other site
648757009137	GEF interaction site [polypeptide binding]; other site
648757009138	Rab family motif 2 (RabF2); other site
648757009139	G3 box; other site
648757009140	Switch II region; other site
648757009141	Rab family motif 3 (RabF3); other site
648757009142	Rab family motif 4 (RabF4); other site
648757009143	Rab family motif 5 (RabF5); other site
648757009144	Rab subfamily motif 3 (RabSF3); other site
648757009145	G4 box; other site
648757009146	G5 box; other site
648757009147	Rab subfamily motif 4 (RabSF4); other site
648757009148	proteobacterial sortase system OmpA family protein; Region: pdsO; TIGR03789
648757009149	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
648757009150	ligand binding site [chemical binding]; other site
648757009151	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
648757009152	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
648757009153	N-terminal plug; other site
648757009154	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
648757009155	ligand-binding site [chemical binding]; other site
648757009156	FeoA domain; Region: FeoA; cl00838
648757009157	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
648757009158	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
648757009159	G1 box; other site
648757009160	GTP/Mg2+ binding site [chemical binding]; other site
648757009161	Switch I region; other site
648757009162	G2 box; other site
648757009163	G3 box; other site
648757009164	Switch II region; other site
648757009165	G4 box; other site
648757009166	G5 box; other site
648757009167	Nucleoside recognition; Region: Gate; cl00486
648757009168	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
648757009169	Nucleoside recognition; Region: Gate; cl00486
648757009170	Helix-turn-helix domains; Region: HTH; cl00088
648757009171	Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647
648757009172	Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882
648757009173	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
648757009174	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
648757009175	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
648757009176	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668
648757009177	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
648757009178	GAF domain; Region: GAF; cl15785
648757009179	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
648757009180	Walker A motif; other site
648757009181	ATP binding site [chemical binding]; other site
648757009182	Walker B motif; other site
648757009183	arginine finger; other site
648757009184	Helix-turn-helix domains; Region: HTH; cl00088
648757009185	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
648757009186	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
648757009187	Helix-turn-helix domains; Region: HTH; cl00088
648757009188	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
648757009189	TOBE domain; Region: TOBE_2; cl01440
648757009190	TOBE domain; Region: TOBE_2; cl01440
648757009191	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
648757009192	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
648757009193	catalytic loop [active]
648757009194	iron binding site [ion binding]; other site
648757009195	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
648757009196	diiron binding motif [ion binding]; other site
648757009197	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
648757009198	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757009199	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
648757009200	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
648757009201	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
648757009202	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
648757009203	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
648757009204	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
648757009205	Bacitracin resistance protein BacA; Region: BacA; cl00858
648757009206	GTP cyclohydrolase; Provisional; Region: PRK08815
648757009207	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
648757009208	dimerization interface [polypeptide binding]; other site
648757009209	active site
648757009210	Helix-turn-helix domains; Region: HTH; cl00088
648757009211	Winged helix-turn helix; Region: HTH_29; pfam13551
648757009212	Integrase core domain; Region: rve; cl01316
648757009213	DDE domain; Region: DDE_Tnp_IS240; pfam13610
648757009214	Integrase core domain; Region: rve_3; cl15866
648757009215	pteridine reductase; Provisional; Region: PRK09135
648757009216	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757009217	NAD(P) binding site [chemical binding]; other site
648757009218	active site
648757009219	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
648757009220	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
648757009221	GIY-YIG motif/motif A; other site
648757009222	active site
648757009223	catalytic site [active]
648757009224	putative DNA binding site [nucleotide binding]; other site
648757009225	metal binding site [ion binding]; metal-binding site
648757009226	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
648757009227	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
648757009228	Hef nuclease; Provisional; Region: PRK13766
648757009229	YCII-related domain; Region: YCII; cl00999
648757009230	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
648757009231	putative deacylase active site [active]
648757009232	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
648757009233	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
648757009234	substrate-cofactor binding pocket; other site
648757009235	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757009236	catalytic residue [active]
648757009237	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
648757009238	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
648757009239	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
648757009240	catalytic site [active]
648757009241	subunit interface [polypeptide binding]; other site
648757009242	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
648757009243	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757009244	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
648757009245	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
648757009246	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
648757009247	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
648757009248	Ligand binding site [chemical binding]; other site
648757009249	Electron transfer flavoprotein domain; Region: ETF; pfam01012
648757009250	Rhomboid family; Region: Rhomboid; cl11446
648757009251	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
648757009252	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
648757009253	ORF059 IMV protein VP55; Provisional; Region: PHA02688
648757009254	probable methyltransferase; Region: TIGR03438
648757009255	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
648757009256	TIGR03440 family protein; Region: unchr_TIGR03440
648757009257	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
648757009258	Protein of unknown function (DUF1052); Region: DUF1052; cl02197
648757009259	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
648757009260	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
648757009261	putative active site [active]
648757009262	substrate binding site [chemical binding]; other site
648757009263	putative cosubstrate binding site; other site
648757009264	catalytic site [active]
648757009265	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
648757009266	substrate binding site [chemical binding]; other site
648757009267	Protein of unknown function (DUF1223); Region: DUF1223; cl10501
648757009268	EVE domain; Region: EVE; cl00728
648757009269	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
648757009270	YGGT family; Region: YGGT; cl00508
648757009271	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
648757009272	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
648757009273	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
648757009274	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
648757009275	homodimer interface [polypeptide binding]; other site
648757009276	NADP binding site [chemical binding]; other site
648757009277	substrate binding site [chemical binding]; other site
648757009278	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
648757009279	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
648757009280	catalytic triad [active]
648757009281	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673
648757009282	nudix motif; other site
648757009283	Protein of unknown function (DUF2385); Region: DUF2385; cl11490
648757009284	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
648757009285	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
648757009286	lipoyl-biotinyl attachment site [posttranslational modification]; other site
648757009287	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
648757009288	active site
648757009289	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
648757009290	homodimer interface [polypeptide binding]; other site
648757009291	bacteriophage N4 adsorption protein B; Provisional; Region: PRK14716
648757009292	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
648757009293	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
648757009294	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
648757009295	active site
648757009296	substrate binding site [chemical binding]; other site
648757009297	metal binding site [ion binding]; metal-binding site
648757009298	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
648757009299	dimerization interface [polypeptide binding]; other site
648757009300	putative DNA binding site [nucleotide binding]; other site
648757009301	putative Zn2+ binding site [ion binding]; other site
648757009302	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
648757009303	Membrane transport protein; Region: Mem_trans; cl09117
648757009304	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
648757009305	ArsC family; Region: ArsC; pfam03960
648757009306	catalytic residues [active]
648757009307	Low molecular weight phosphatase family; Region: LMWPc; cd00115
648757009308	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
648757009309	active site
648757009310	Methyltransferase domain; Region: Methyltransf_31; pfam13847
648757009311	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
648757009312	S-adenosylmethionine binding site [chemical binding]; other site
648757009313	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
648757009314	dimerization interface [polypeptide binding]; other site
648757009315	putative DNA binding site [nucleotide binding]; other site
648757009316	putative Zn2+ binding site [ion binding]; other site
648757009317	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
648757009318	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
648757009319	Walker A/P-loop; other site
648757009320	ATP binding site [chemical binding]; other site
648757009321	Q-loop/lid; other site
648757009322	ABC transporter signature motif; other site
648757009323	Walker B; other site
648757009324	D-loop; other site
648757009325	H-loop/switch region; other site
648757009326	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
648757009327	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
648757009328	FtsX-like permease family; Region: FtsX; cl15850
648757009329	Low molecular weight phosphatase family; Region: LMWPc; cd00115
648757009330	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
648757009331	active site
648757009332	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
648757009333	active site
648757009334	ATP binding site [chemical binding]; other site
648757009335	substrate binding site [chemical binding]; other site
648757009336	prolyl-tRNA synthetase; Provisional; Region: PRK08661
648757009337	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_arch_euk; cd00778
648757009338	dimer interface [polypeptide binding]; other site
648757009339	motif 1; other site
648757009340	active site
648757009341	motif 2; other site
648757009342	motif 3; other site
648757009343	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
648757009344	anticodon binding site; other site
648757009345	FOG: CBS domain [General function prediction only]; Region: COG0517
648757009346	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
648757009347	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
648757009348	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757009349	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
648757009350	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
648757009351	S-adenosylmethionine binding site [chemical binding]; other site
648757009352	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757009353	Low molecular weight phosphatase family; Region: LMWPc; cd00115
648757009354	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
648757009355	active site
648757009356	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
648757009357	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
648757009358	putative acyl-acceptor binding pocket; other site
648757009359	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757009360	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494
648757009361	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
648757009362	NMT1-like family; Region: NMT1_2; cl15260
648757009363	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
648757009364	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
648757009365	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
648757009366	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
648757009367	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
648757009368	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
648757009369	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
648757009370	Walker A/P-loop; other site
648757009371	ATP binding site [chemical binding]; other site
648757009372	Q-loop/lid; other site
648757009373	ABC transporter signature motif; other site
648757009374	Walker B; other site
648757009375	D-loop; other site
648757009376	H-loop/switch region; other site
648757009377	radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043
648757009378	H+ Antiporter protein; Region: 2A0121; TIGR00900
648757009379	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757009380	nitrogenase iron protein; Region: nifH; TIGR01287
648757009381	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
648757009382	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
648757009383	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
648757009384	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
648757009385	HEAT repeats; Region: HEAT_2; pfam13646
648757009386	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
648757009387	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
648757009388	TPR motif; other site
648757009389	binding surface
648757009390	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
648757009391	Sulfatase; Region: Sulfatase; cl10460
648757009392	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102
648757009393	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
648757009394	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
648757009395	N-terminal plug; other site
648757009396	ligand-binding site [chemical binding]; other site
648757009397	Gram-negative bacterial tonB protein; Region: TonB; cl10048
648757009398	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
648757009399	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
648757009400	Helix-turn-helix domains; Region: HTH; cl00088
648757009401	Winged helix-turn helix; Region: HTH_29; pfam13551
648757009402	Integrase core domain; Region: rve; cl01316
648757009403	DDE domain; Region: DDE_Tnp_IS240; pfam13610
648757009404	Integrase core domain; Region: rve_3; cl15866
648757009405	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
648757009406	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
648757009407	NMT1-like family; Region: NMT1_2; cl15260
648757009408	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
648757009409	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
648757009410	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
648757009411	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
648757009412	Walker A/P-loop; other site
648757009413	ATP binding site [chemical binding]; other site
648757009414	Q-loop/lid; other site
648757009415	ABC transporter signature motif; other site
648757009416	Walker B; other site
648757009417	D-loop; other site
648757009418	H-loop/switch region; other site
648757009419	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757009420	Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721
648757009421	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
648757009422	SAF domain; Region: SAF; cl00555
648757009423	Helix-turn-helix domains; Region: HTH; cl00088
648757009424	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
648757009425	substrate-cofactor binding pocket; other site
648757009426	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757009427	catalytic residue [active]
648757009428	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
648757009429	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
648757009430	homodimer interface [polypeptide binding]; other site
648757009431	substrate-cofactor binding pocket; other site
648757009432	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757009433	catalytic residue [active]
648757009434	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
648757009435	Cupin domain; Region: Cupin_2; cl09118
648757009436	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
648757009437	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
648757009438	substrate binding pocket [chemical binding]; other site
648757009439	membrane-bound complex binding site; other site
648757009440	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
648757009441	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
648757009442	dimer interface [polypeptide binding]; other site
648757009443	ABC-ATPase subunit interface; other site
648757009444	putative PBP binding loops; other site
648757009445	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
648757009446	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
648757009447	Walker A/P-loop; other site
648757009448	ATP binding site [chemical binding]; other site
648757009449	Q-loop/lid; other site
648757009450	ABC transporter signature motif; other site
648757009451	Walker B; other site
648757009452	D-loop; other site
648757009453	H-loop/switch region; other site
648757009454	Protein of unknown function (DUF1847); Region: DUF1847; cl02037
648757009455	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
648757009456	Radical SAM superfamily; Region: Radical_SAM; pfam04055
648757009457	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
648757009458	FeS/SAM binding site; other site
648757009459	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
648757009460	nitrogenase iron protein; Region: nifH; TIGR01287
648757009461	Nucleotide-binding sites [chemical binding]; other site
648757009462	Walker A motif; other site
648757009463	Switch I region of nucleotide binding site; other site
648757009464	Fe4S4 binding sites [ion binding]; other site
648757009465	Switch II region of nucleotide binding site; other site
648757009466	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
648757009467	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
648757009468	Nitrogenase_vnfN_like: VnfN subunit of the VnfEN complex-like.  This group in addition to VnfN contains a subset of the beta subunit of the nitrogenase MoFe protein and NifN-like proteins. The nitrogenase enzyme system catalyzes the ATP-dependent...; Region: Nitrogenase_VnfN_like; cd01971
648757009469	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
648757009470	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
648757009471	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
648757009472	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
648757009473	catalytic residue [active]
648757009474	OsmC-like protein; Region: OsmC; cl00767
648757009475	acetyl-CoA synthetase; Provisional; Region: PRK00174
648757009476	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
648757009477	AMP-binding enzyme; Region: AMP-binding; cl15778
648757009478	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
648757009479	NMT1/THI5 like; Region: NMT1; pfam09084
648757009480	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
648757009481	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
648757009482	dimer interface [polypeptide binding]; other site
648757009483	conserved gate region; other site
648757009484	ABC-ATPase subunit interface; other site
648757009485	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
648757009486	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
648757009487	Walker A/P-loop; other site
648757009488	ATP binding site [chemical binding]; other site
648757009489	Q-loop/lid; other site
648757009490	ABC transporter signature motif; other site
648757009491	Walker B; other site
648757009492	D-loop; other site
648757009493	H-loop/switch region; other site
648757009494	pyruvate formate-lyase; Region: PFL2-3; TIGR01774
648757009495	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
648757009496	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
648757009497	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
648757009498	4Fe-4S binding domain; Region: Fer4; cl02805
648757009499	4Fe-4S binding domain; Region: Fer4; cl02805
648757009500	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
648757009501	FeS/SAM binding site; other site
648757009502	Uncharacterized conserved protein [Function unknown]; Region: COG3391
648757009503	enoyl-CoA hydratase; Validated; Region: PRK08139
648757009504	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
648757009505	substrate binding site [chemical binding]; other site
648757009506	oxyanion hole (OAH) forming residues; other site
648757009507	trimer interface [polypeptide binding]; other site
648757009508	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
648757009509	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
648757009510	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
648757009511	Gram-negative bacterial tonB protein; Region: TonB; cl10048
648757009512	cysteine synthase; Region: PLN02565
648757009513	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
648757009514	dimer interface [polypeptide binding]; other site
648757009515	pyridoxal 5'-phosphate binding site [chemical binding]; other site
648757009516	catalytic residue [active]
648757009517	Rrf2 family protein; Region: rrf2_super; TIGR00738
648757009518	Helix-turn-helix domains; Region: HTH; cl00088
648757009519	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
648757009520	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
648757009521	N-terminal plug; other site
648757009522	ligand-binding site [chemical binding]; other site
648757009523	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
648757009524	benzoyl-CoA reductase, bzd-type, N subunit; Region: benz_CoA_bzdN; cl11464
648757009525	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
648757009526	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
648757009527	Walker A/P-loop; other site
648757009528	ATP binding site [chemical binding]; other site
648757009529	Q-loop/lid; other site
648757009530	ABC transporter signature motif; other site
648757009531	Walker B; other site
648757009532	D-loop; other site
648757009533	H-loop/switch region; other site
648757009534	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
648757009535	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
648757009536	dimer interface [polypeptide binding]; other site
648757009537	conserved gate region; other site
648757009538	putative PBP binding loops; other site
648757009539	ABC-ATPase subunit interface; other site
648757009540	Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775
648757009541	benzoyl-CoA reductase, bzd-type, N subunit; Region: benz_CoA_bzdN; cl11464
648757009542	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
648757009543	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
648757009544	substrate binding pocket [chemical binding]; other site
648757009545	membrane-bound complex binding site; other site
648757009546	hinge residues; other site
648757009547	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
648757009548	H+ Antiporter protein; Region: 2A0121; TIGR00900
648757009549	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
648757009550	putative substrate translocation pore; other site
648757009551	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
648757009552	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
648757009553	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757009554	Walker A/P-loop; other site
648757009555	ATP binding site [chemical binding]; other site
648757009556	Q-loop/lid; other site
648757009557	ABC transporter signature motif; other site
648757009558	Walker B; other site
648757009559	D-loop; other site
648757009560	H-loop/switch region; other site
648757009561	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
648757009562	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
648757009563	Glucan exporter ATP-binding protein.  In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor.  This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254
648757009564	Walker A/P-loop; other site
648757009565	ATP binding site [chemical binding]; other site
648757009566	Q-loop/lid; other site
648757009567	ABC transporter signature motif; other site
648757009568	Walker B; other site
648757009569	D-loop; other site
648757009570	H-loop/switch region; other site
648757009571	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
648757009572	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
648757009573	ligand binding site [chemical binding]; other site
648757009574	flexible hinge region; other site
648757009575	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
648757009576	putative switch regulator; other site
648757009577	non-specific DNA interactions [nucleotide binding]; other site
648757009578	DNA binding site [nucleotide binding]
648757009579	sequence specific DNA binding site [nucleotide binding]; other site
648757009580	putative cAMP binding site [chemical binding]; other site
648757009581	NADH ubiquinone oxidoreductase subunit NDUFA12; Region: NDUFA12; cl01534
648757009582	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
648757009583	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
648757009584	S-adenosylmethionine binding site [chemical binding]; other site
648757009585	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
648757009586	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
648757009587	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
648757009588	ABC transporter; Region: ABC_tran_2; pfam12848
648757009589	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
648757009590	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
648757009591	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
648757009592	ATP binding site [chemical binding]; other site
648757009593	putative Mg++ binding site [ion binding]; other site
648757009594	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
648757009595	nucleotide binding region [chemical binding]; other site
648757009596	ATP-binding site [chemical binding]; other site
648757009597	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
648757009598	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
648757009599	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
648757009600	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
648757009601	active site
648757009602	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
648757009603	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
648757009604	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
648757009605	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757009606	Predicted acetyltransferase [General function prediction only]; Region: COG3153
648757009607	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
648757009608	NADH dehydrogenase subunit G; Validated; Region: PRK09130
648757009609	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
648757009610	catalytic loop [active]
648757009611	iron binding site [ion binding]; other site
648757009612	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
648757009613	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
648757009614	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
648757009615	NADH dehydrogenase; Region: NADHdh; cl00469
648757009616	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
648757009617	4Fe-4S binding domain; Region: Fer4; cl02805
648757009618	4Fe-4S binding domain; Region: Fer4; cl02805
648757009619	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
648757009620	NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634
648757009621	NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634
648757009622	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
648757009623	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
648757009624	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
648757009625	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
648757009626	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
648757009627	NADH-ubiquinone oxidoreductase chain 4, amino terminus; Region: Oxidored_q5_N; pfam01059
648757009628	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
648757009629	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
648757009630	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
648757009631	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
648757009632	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
648757009633	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
648757009634	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
648757009635	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
648757009636	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
648757009637	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
648757009638	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
648757009639	dimer interface [polypeptide binding]; other site
648757009640	substrate binding site [chemical binding]; other site
648757009641	metal binding site [ion binding]; metal-binding site
648757009642	tricarballylate dehydrogenase; Validated; Region: PRK08274
648757009643	CitB domain protein; Region: CitB; TIGR02484
648757009644	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
648757009645	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
648757009646	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
648757009647	conserved cys residue [active]
648757009648	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
648757009649	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
648757009650	Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133
648757009651	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
648757009652	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
648757009653	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
648757009654	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
648757009655	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922
648757009656	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
648757009657	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
648757009658	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
648757009659	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
648757009660	Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913
648757009661	CobD/Cbib protein; Region: CobD_Cbib; cl00561
648757009662	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
648757009663	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
648757009664	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
648757009665	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
648757009666	catalytic residue [active]
648757009667	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
648757009668	catalytic residue [active]
648757009669	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
648757009670	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
648757009671	FeS/SAM binding site; other site
648757009672	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
648757009673	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
648757009674	putative FMN binding site [chemical binding]; other site
648757009675	Cysteine-rich domain; Region: CCG; pfam02754
648757009676	Cysteine-rich domain; Region: CCG; pfam02754
648757009677	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
648757009678	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
648757009679	NAD binding site [chemical binding]; other site
648757009680	putative substrate binding site 2 [chemical binding]; other site
648757009681	putative substrate binding site 1 [chemical binding]; other site
648757009682	active site
648757009683	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
648757009684	homoserine dehydrogenase; Provisional; Region: PRK06349
648757009685	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757009686	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
648757009687	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
648757009688	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
648757009689	active site
648757009690	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
648757009691	NodB motif; other site
648757009692	active site
648757009693	catalytic site [active]
648757009694	metal binding site [ion binding]; metal-binding site
648757009695	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
648757009696	PAS domain; Region: PAS_9; pfam13426
648757009697	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
648757009698	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
648757009699	dimer interface [polypeptide binding]; other site
648757009700	phosphorylation site [posttranslational modification]
648757009701	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
648757009702	ATP binding site [chemical binding]; other site
648757009703	Mg2+ binding site [ion binding]; other site
648757009704	G-X-G motif; other site
648757009705	Response regulator receiver domain; Region: Response_reg; pfam00072
648757009706	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
648757009707	active site
648757009708	phosphorylation site [posttranslational modification]
648757009709	intermolecular recognition site; other site
648757009710	dimerization interface [polypeptide binding]; other site
648757009711	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
648757009712	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
648757009713	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
648757009714	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771
648757009715	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
648757009716	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346
648757009717	NADH dehydrogenase subunit E; Provisional; Region: PRK12373
648757009718	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
648757009719	putative dimer interface [polypeptide binding]; other site
648757009720	[2Fe-2S] cluster binding site [ion binding]; other site
648757009721	Uncharacterized conserved protein [Function unknown]; Region: COG3743
648757009722	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
648757009723	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
648757009724	SLBB domain; Region: SLBB; pfam10531
648757009725	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
648757009726	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
648757009727	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
648757009728	NAD(P) binding site [chemical binding]; other site
648757009729	active site
648757009730	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
648757009731	Aerotolerance regulator N-terminal; Region: BatA; cl06567
648757009732	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
648757009733	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
648757009734	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
648757009735	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
648757009736	MoxR-like ATPases [General function prediction only]; Region: COG0714
648757009737	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
648757009738	Walker A motif; other site
648757009739	ATP binding site [chemical binding]; other site
648757009740	Walker B motif; other site
648757009741	arginine finger; other site
648757009742	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
648757009743	putative active site [active]
648757009744	putative CoA binding site [chemical binding]; other site
648757009745	nudix motif; other site
648757009746	metal binding site [ion binding]; metal-binding site
648757009747	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
648757009748	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
648757009749	active site
648757009750	NTP binding site [chemical binding]; other site
648757009751	metal binding triad [ion binding]; metal-binding site
648757009752	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
648757009753	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384