-- dump date 20120504_160757 -- class Genbank::misc_feature -- table misc_feature_note -- id note 383372000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 383372000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 383372000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 383372000004 Walker A motif; other site 383372000005 ATP binding site [chemical binding]; other site 383372000006 Walker B motif; other site 383372000007 arginine finger; other site 383372000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 383372000009 DnaA box-binding interface [nucleotide binding]; other site 383372000010 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 383372000011 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 383372000012 active site 383372000013 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 383372000014 HIT family signature motif; other site 383372000015 catalytic residue [active] 383372000016 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 383372000017 hypothetical protein; Provisional; Region: PRK08609 383372000018 active site 383372000019 primer binding site [nucleotide binding]; other site 383372000020 NTP binding site [chemical binding]; other site 383372000021 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 383372000022 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 383372000023 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 383372000024 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 383372000025 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 383372000026 dimer interface [polypeptide binding]; other site 383372000027 putative anticodon binding site; other site 383372000028 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 383372000029 motif 1; other site 383372000030 active site 383372000031 motif 2; other site 383372000032 motif 3; other site 383372000033 Fic/DOC family; Region: Fic; cl00960 383372000034 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372000035 NAD(P) binding site [chemical binding]; other site 383372000036 active site 383372000037 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 383372000038 putative acyl-acceptor binding pocket; other site 383372000039 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 383372000040 Ligand binding site; other site 383372000041 Putative Catalytic site; other site 383372000042 DXD motif; other site 383372000043 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 383372000044 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 383372000045 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 383372000046 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 383372000047 Mg++ binding site [ion binding]; other site 383372000048 putative catalytic motif [active] 383372000049 substrate binding site [chemical binding]; other site 383372000050 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 383372000051 acetylornithine deacetylase; Validated; Region: PRK06915 383372000052 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 383372000053 metal binding site [ion binding]; metal-binding site 383372000054 dimer interface [polypeptide binding]; other site 383372000055 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 383372000056 Amidinotransferase; Region: Amidinotransf; cl12043 383372000057 Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751 383372000058 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 383372000059 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 383372000060 Zn binding site [ion binding]; other site 383372000061 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 383372000062 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 383372000063 Zn binding site [ion binding]; other site 383372000064 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 383372000065 putative cation:proton antiport protein; Provisional; Region: PRK10669 383372000066 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372000067 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 383372000068 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 383372000069 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 383372000070 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 383372000071 DNA binding residues [nucleotide binding] 383372000072 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 383372000073 Putative zinc-finger; Region: zf-HC2; cl15806 383372000074 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 383372000075 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 383372000076 dimer interface [polypeptide binding]; other site 383372000077 ssDNA binding site [nucleotide binding]; other site 383372000078 tetramer (dimer of dimers) interface [polypeptide binding]; other site 383372000079 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 383372000080 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 383372000081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372000082 S-adenosylmethionine binding site [chemical binding]; other site 383372000083 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372000084 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 383372000085 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 383372000086 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 383372000087 Substrate-binding site [chemical binding]; other site 383372000088 Substrate specificity [chemical binding]; other site 383372000089 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 383372000090 hydrophobic ligand binding site; other site 383372000091 cyclase homology domain; Region: CHD; cd07302 383372000092 nucleotidyl binding site; other site 383372000093 metal binding site [ion binding]; metal-binding site 383372000094 dimer interface [polypeptide binding]; other site 383372000095 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372000096 binding surface 383372000097 TPR repeat; Region: TPR_11; pfam13414 383372000098 TPR motif; other site 383372000099 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372000100 binding surface 383372000101 TPR repeat; Region: TPR_11; pfam13414 383372000102 TPR motif; other site 383372000103 Tetratricopeptide repeat; Region: TPR_16; pfam13432 383372000104 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 383372000105 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 383372000106 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 383372000107 active site 383372000108 multimer interface [polypeptide binding]; other site 383372000109 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 383372000110 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 383372000111 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 383372000112 VanW like protein; Region: VanW; pfam04294 383372000113 G5 domain; Region: G5; pfam07501 383372000114 hypothetical protein; Reviewed; Region: PRK00024 383372000115 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 383372000116 MPN+ (JAMM) motif; other site 383372000117 Zinc-binding site [ion binding]; other site 383372000118 Peptidase family M23; Region: Peptidase_M23; pfam01551 383372000119 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 383372000120 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 383372000121 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 383372000122 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 383372000123 NAD(P) binding site [chemical binding]; other site 383372000124 catalytic residues [active] 383372000125 Uncharacterized conserved protein [Function unknown]; Region: COG2912 383372000126 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 383372000127 Helix-turn-helix domains; Region: HTH; cl00088 383372000128 DNA-binding site [nucleotide binding]; DNA binding site 383372000129 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 383372000130 DNA binding site [nucleotide binding] 383372000131 Int/Topo IB signature motif; other site 383372000132 active site 383372000133 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 383372000134 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 383372000135 NAD binding site [chemical binding]; other site 383372000136 substrate binding site [chemical binding]; other site 383372000137 active site 383372000138 glycyl-tRNA synthetase; Provisional; Region: PRK14894 383372000139 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 383372000140 dimer interface [polypeptide binding]; other site 383372000141 motif 1; other site 383372000142 active site 383372000143 motif 2; other site 383372000144 motif 3; other site 383372000145 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 383372000146 anticodon binding site; other site 383372000147 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 383372000148 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 383372000149 DNA binding site [nucleotide binding] 383372000150 Int/Topo IB signature motif; other site 383372000151 active site 383372000152 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 383372000153 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 383372000154 FMN binding site [chemical binding]; other site 383372000155 active site 383372000156 catalytic residues [active] 383372000157 substrate binding site [chemical binding]; other site 383372000158 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 383372000159 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 383372000160 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 383372000161 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 383372000162 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 383372000163 YacP-like NYN domain; Region: NYN_YacP; cl01491 383372000164 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 383372000165 active site 383372000166 dimerization interface [polypeptide binding]; other site 383372000167 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 383372000168 threonine dehydratase; Provisional; Region: PRK08198 383372000169 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 383372000170 tetramer interface [polypeptide binding]; other site 383372000171 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372000172 catalytic residue [active] 383372000173 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 383372000174 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 383372000175 HEAT repeats; Region: HEAT_2; pfam13646 383372000176 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 383372000177 Helix-turn-helix domains; Region: HTH; cl00088 383372000178 DNA binding site [nucleotide binding] 383372000179 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 383372000180 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 383372000181 Walker A/P-loop; other site 383372000182 ATP binding site [chemical binding]; other site 383372000183 Q-loop/lid; other site 383372000184 ABC transporter signature motif; other site 383372000185 Walker B; other site 383372000186 D-loop; other site 383372000187 H-loop/switch region; other site 383372000188 Smr domain; Region: Smr; cl02619 383372000189 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 383372000190 putative peptidoglycan binding site; other site 383372000191 YcxB-like protein; Region: YcxB; pfam14317 383372000192 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 383372000193 putative peptidoglycan binding site; other site 383372000194 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 383372000195 NodB motif; other site 383372000196 active site 383372000197 catalytic site [active] 383372000198 metal binding site [ion binding]; metal-binding site 383372000199 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 383372000200 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 383372000201 Catalytic GIY-YIG domain of type II restriction enzyme R.Cfr42I and similar proteins; Region: GIY-YIG_RE_Cfr42I; cd10453 383372000202 GIY-YIG motif/motif A; other site 383372000203 putative active site [active] 383372000204 putative metal binding site [ion binding]; other site 383372000205 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372000206 AAA-like domain; Region: AAA_10; pfam12846 383372000207 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 383372000208 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 383372000209 ADP-ribose binding site [chemical binding]; other site 383372000210 enolase; Provisional; Region: eno; PRK00077 383372000211 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 383372000212 dimer interface [polypeptide binding]; other site 383372000213 metal binding site [ion binding]; metal-binding site 383372000214 substrate binding pocket [chemical binding]; other site 383372000215 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 383372000216 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372000217 DRTGG domain; Region: DRTGG; cl12147 383372000218 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 383372000219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372000220 CoA-ligase; Region: Ligase_CoA; cl02894 383372000221 ATP-grasp domain; Region: ATP-grasp_4; cl03087 383372000222 leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396 383372000223 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 383372000224 HIGH motif; other site 383372000225 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 383372000226 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 383372000227 active site 383372000228 KMSKS motif; other site 383372000229 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 383372000230 tRNA binding surface [nucleotide binding]; other site 383372000231 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372000232 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 383372000233 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 383372000234 Protein of unknown function (DUF433); Region: DUF433; cl01030 383372000235 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 383372000236 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 383372000237 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 383372000238 active site 383372000239 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 383372000240 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 383372000241 active site 383372000242 catalytic tetrad [active] 383372000243 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 383372000244 elongation factor G; Reviewed; Region: PRK12740 383372000245 G1 box; other site 383372000246 putative GEF interaction site [polypeptide binding]; other site 383372000247 GTP/Mg2+ binding site [chemical binding]; other site 383372000248 Switch I region; other site 383372000249 G2 box; other site 383372000250 G3 box; other site 383372000251 Switch II region; other site 383372000252 G4 box; other site 383372000253 G5 box; other site 383372000254 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 383372000255 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 383372000256 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 383372000257 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 383372000258 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 383372000259 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 383372000260 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 383372000261 active site 383372000262 NTP binding site [chemical binding]; other site 383372000263 metal binding triad [ion binding]; metal-binding site 383372000264 antibiotic binding site [chemical binding]; other site 383372000265 Protein of unknown function DUF86; Region: DUF86; cl01031 383372000266 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 383372000267 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 383372000268 putative [4Fe-4S] binding site [ion binding]; other site 383372000269 putative molybdopterin cofactor binding site [chemical binding]; other site 383372000270 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 383372000271 putative molybdopterin cofactor binding site; other site 383372000272 shikimate kinase; Reviewed; Region: aroK; PRK00131 383372000273 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 383372000274 ADP binding site [chemical binding]; other site 383372000275 magnesium binding site [ion binding]; other site 383372000276 putative shikimate binding site; other site 383372000277 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 383372000278 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 383372000279 active site 383372000280 dimer interface [polypeptide binding]; other site 383372000281 metal binding site [ion binding]; metal-binding site 383372000282 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl08495 383372000283 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 383372000284 active site 383372000285 NTP binding site [chemical binding]; other site 383372000286 metal binding triad [ion binding]; metal-binding site 383372000287 antibiotic binding site [chemical binding]; other site 383372000288 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 383372000289 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 383372000290 Protein phosphatase 2C; Region: PP2C; pfam00481 383372000291 active site 383372000292 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 383372000293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372000294 ATP binding site [chemical binding]; other site 383372000295 Mg2+ binding site [ion binding]; other site 383372000296 G-X-G motif; other site 383372000297 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 383372000298 ATP binding site [chemical binding]; other site 383372000299 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 383372000300 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 383372000301 Helix-turn-helix domains; Region: HTH; cl00088 383372000302 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 383372000303 FeoA domain; Region: FeoA; cl00838 383372000304 Protein of unknown function (DUF952); Region: DUF952; cl01393 383372000305 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 383372000306 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 383372000307 putative N- and C-terminal domain interface [polypeptide binding]; other site 383372000308 putative active site [active] 383372000309 putative MgATP binding site [chemical binding]; other site 383372000310 catalytic site [active] 383372000311 metal binding site [ion binding]; metal-binding site 383372000312 putative carbohydrate binding site [chemical binding]; other site 383372000313 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 383372000314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372000315 NAD(P) binding site [chemical binding]; other site 383372000316 active site 383372000317 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 383372000318 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 383372000319 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 383372000320 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 383372000321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372000322 dimer interface [polypeptide binding]; other site 383372000323 conserved gate region; other site 383372000324 putative PBP binding loops; other site 383372000325 ABC-ATPase subunit interface; other site 383372000326 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 383372000327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 383372000328 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 383372000329 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 383372000330 Walker A/P-loop; other site 383372000331 ATP binding site [chemical binding]; other site 383372000332 Q-loop/lid; other site 383372000333 ABC transporter signature motif; other site 383372000334 Walker B; other site 383372000335 D-loop; other site 383372000336 H-loop/switch region; other site 383372000337 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; cl15413 383372000338 MgtC family; Region: MgtC; pfam02308 383372000339 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 383372000340 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 383372000341 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 383372000342 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 383372000343 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 383372000344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372000345 dimer interface [polypeptide binding]; other site 383372000346 conserved gate region; other site 383372000347 putative PBP binding loops; other site 383372000348 ABC-ATPase subunit interface; other site 383372000349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372000350 dimer interface [polypeptide binding]; other site 383372000351 putative PBP binding loops; other site 383372000352 ABC-ATPase subunit interface; other site 383372000353 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 383372000354 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 383372000355 inhibitor-cofactor binding pocket; inhibition site 383372000356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372000357 catalytic residue [active] 383372000358 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372000359 putative active site [active] 383372000360 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 383372000361 Coenzyme A binding pocket [chemical binding]; other site 383372000362 histidyl-tRNA synthetase; Region: hisS; TIGR00442 383372000363 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 383372000364 dimer interface [polypeptide binding]; other site 383372000365 motif 1; other site 383372000366 active site 383372000367 motif 2; other site 383372000368 motif 3; other site 383372000369 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 383372000370 anticodon binding site; other site 383372000371 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 383372000372 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 383372000373 ATP cone domain; Region: ATP-cone; pfam03477 383372000374 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 383372000375 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 383372000376 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 383372000377 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 383372000378 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 383372000379 conserved cys residue [active] 383372000380 PAS fold; Region: PAS_4; pfam08448 383372000381 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 383372000382 putative active site [active] 383372000383 heme pocket [chemical binding]; other site 383372000384 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 383372000385 PAS fold; Region: PAS_4; pfam08448 383372000386 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 383372000387 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 383372000388 Amino acid permease; Region: AA_permease_2; pfam13520 383372000389 Putative cyclase; Region: Cyclase; cl00814 383372000390 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 383372000391 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 383372000392 active site 383372000393 metal binding site [ion binding]; metal-binding site 383372000394 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372000395 putative active site [active] 383372000396 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 383372000397 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 383372000398 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 383372000399 Helix-turn-helix domains; Region: HTH; cl00088 383372000400 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 383372000401 C-terminal domain interface [polypeptide binding]; other site 383372000402 sugar binding site [chemical binding]; other site 383372000403 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 383372000404 active site 383372000405 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 383372000406 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 383372000407 active site 383372000408 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 383372000409 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 383372000410 Probable Catalytic site; other site 383372000411 metal-binding site 383372000412 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 383372000413 Putative transmembrane protein; Region: Tmp39; pfam10271 383372000414 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372000415 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372000416 S-adenosylmethionine binding site [chemical binding]; other site 383372000417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372000418 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 383372000419 DNA binding residues [nucleotide binding] 383372000420 dimerization interface [polypeptide binding]; other site 383372000421 Kelch motif; Region: Kelch_1; cl02701 383372000422 Kelch motif; Region: Kelch_1; cl02701 383372000423 Kelch motif; Region: Kelch_1; cl02701 383372000424 Kelch motif; Region: Kelch_1; cl02701 383372000425 Transposase; Region: HTH_Tnp_IS630; pfam01710 383372000426 Winged helix-turn helix; Region: HTH_33; pfam13592 383372000427 Integrase core domain; Region: rve; cl01316 383372000428 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 383372000429 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 383372000430 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 383372000431 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 383372000432 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 383372000433 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372000434 NAD(P) binding site [chemical binding]; other site 383372000435 active site 383372000436 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 383372000437 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 383372000438 dimer interface [polypeptide binding]; other site 383372000439 substrate binding site [chemical binding]; other site 383372000440 metal binding site [ion binding]; metal-binding site 383372000441 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 383372000442 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 383372000443 GAF domain; Region: GAF; cl15785 383372000444 GAF domain; Region: GAF_2; pfam13185 383372000445 GAF domain; Region: GAF; cl15785 383372000446 GAF domain; Region: GAF_2; pfam13185 383372000447 GAF domain; Region: GAF; cl15785 383372000448 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 383372000449 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 383372000450 putative active site [active] 383372000451 heme pocket [chemical binding]; other site 383372000452 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372000453 dimer interface [polypeptide binding]; other site 383372000454 phosphorylation site [posttranslational modification] 383372000455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372000456 ATP binding site [chemical binding]; other site 383372000457 Mg2+ binding site [ion binding]; other site 383372000458 G-X-G motif; other site 383372000459 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 383372000460 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 383372000461 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 383372000462 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 383372000463 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 383372000464 substrate binding site [chemical binding]; other site 383372000465 ATP binding site [chemical binding]; other site 383372000466 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 383372000467 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372000468 oligomerization interface [polypeptide binding]; other site 383372000469 active site 383372000470 NAD+ binding site [chemical binding]; other site 383372000471 S-adenosylmethionine synthetase; Validated; Region: PRK05250 383372000472 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 383372000473 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 383372000474 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 383372000475 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 383372000476 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 383372000477 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 383372000478 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 383372000479 Walker A/P-loop; other site 383372000480 ATP binding site [chemical binding]; other site 383372000481 Q-loop/lid; other site 383372000482 ABC transporter signature motif; other site 383372000483 Walker B; other site 383372000484 D-loop; other site 383372000485 H-loop/switch region; other site 383372000486 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; cl15413 383372000487 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 383372000488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372000489 dimer interface [polypeptide binding]; other site 383372000490 conserved gate region; other site 383372000491 putative PBP binding loops; other site 383372000492 ABC-ATPase subunit interface; other site 383372000493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 383372000494 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 383372000495 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 383372000496 RNA binding surface [nucleotide binding]; other site 383372000497 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 383372000498 active site 383372000499 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 383372000500 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 383372000501 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 383372000502 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 383372000503 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 383372000504 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 383372000505 catalytic core [active] 383372000506 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 383372000507 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 383372000508 DinB superfamily; Region: DinB_2; pfam12867 383372000509 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 383372000510 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 383372000511 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 383372000512 Predicted integral membrane protein [Function unknown]; Region: COG0392 383372000513 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 383372000514 hypothetical protein; Provisional; Region: PRK07233 383372000515 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372000516 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 383372000517 extended (e) SDRs; Region: SDR_e; cd08946 383372000518 NAD(P) binding site [chemical binding]; other site 383372000519 active site 383372000520 substrate binding site [chemical binding]; other site 383372000521 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 383372000522 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 383372000523 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 383372000524 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 383372000525 CRISPR-associated protein; Region: TIGR03986 383372000526 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 383372000527 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 383372000528 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 383372000529 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 383372000530 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 383372000531 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 383372000532 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 383372000533 metal binding site [ion binding]; metal-binding site 383372000534 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 383372000535 peptide binding site [polypeptide binding]; other site 383372000536 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 383372000537 dimer interface [polypeptide binding]; other site 383372000538 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 383372000539 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 383372000540 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 383372000541 generic binding surface II; other site 383372000542 generic binding surface I; other site 383372000543 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 383372000544 Catalytic site; other site 383372000545 Lamin Tail Domain; Region: LTD; pfam00932 383372000546 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 383372000547 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 383372000548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372000549 homodimer interface [polypeptide binding]; other site 383372000550 catalytic residue [active] 383372000551 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 383372000552 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 383372000553 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 383372000554 Ligand binding site; other site 383372000555 Putative Catalytic site; other site 383372000556 DXD motif; other site 383372000557 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372000558 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 383372000559 NAD(P) binding site [chemical binding]; other site 383372000560 active site 383372000561 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 383372000562 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 383372000563 inhibitor-cofactor binding pocket; inhibition site 383372000564 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372000565 catalytic residue [active] 383372000566 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 383372000567 OsmC-like protein; Region: OsmC; cl00767 383372000568 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 383372000569 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 383372000570 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 383372000571 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 383372000572 active site 383372000573 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 383372000574 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 383372000575 putative substrate binding site [chemical binding]; other site 383372000576 putative ATP binding site [chemical binding]; other site 383372000577 MoxR-like ATPases [General function prediction only]; Region: COG0714 383372000578 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 383372000579 Walker A motif; other site 383372000580 ATP binding site [chemical binding]; other site 383372000581 Walker B motif; other site 383372000582 arginine finger; other site 383372000583 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 383372000584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372000585 active site 383372000586 phosphorylation site [posttranslational modification] 383372000587 intermolecular recognition site; other site 383372000588 dimerization interface [polypeptide binding]; other site 383372000589 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 383372000590 DNA binding residues [nucleotide binding] 383372000591 dimerization interface [polypeptide binding]; other site 383372000592 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 383372000593 amidase catalytic site [active] 383372000594 Zn binding residues [ion binding]; other site 383372000595 substrate binding site [chemical binding]; other site 383372000596 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372000597 TPR motif; other site 383372000598 binding surface 383372000599 TPR repeat; Region: TPR_11; pfam13414 383372000600 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372000601 binding surface 383372000602 TPR motif; other site 383372000603 TPR repeat; Region: TPR_11; pfam13414 383372000604 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372000605 binding surface 383372000606 TPR motif; other site 383372000607 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372000608 TPR motif; other site 383372000609 binding surface 383372000610 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 383372000611 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372000612 binding surface 383372000613 TPR motif; other site 383372000614 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372000615 TPR motif; other site 383372000616 binding surface 383372000617 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372000618 binding surface 383372000619 TPR motif; other site 383372000620 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372000621 TPR motif; other site 383372000622 binding surface 383372000623 TPR repeat; Region: TPR_11; pfam13414 383372000624 TPR repeat; Region: TPR_11; pfam13414 383372000625 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372000626 binding surface 383372000627 TPR motif; other site 383372000628 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372000629 TPR motif; other site 383372000630 binding surface 383372000631 TPR repeat; Region: TPR_11; pfam13414 383372000632 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372000633 binding surface 383372000634 TPR motif; other site 383372000635 TPR repeat; Region: TPR_11; pfam13414 383372000636 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372000637 putative active site [active] 383372000638 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 383372000639 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 383372000640 nudix motif; other site 383372000641 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 383372000642 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 383372000643 putative active site [active] 383372000644 putative metal binding site [ion binding]; other site 383372000645 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 383372000646 active site 383372000647 catalytic triad [active] 383372000648 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 383372000649 phosphopeptide binding site; other site 383372000650 Haem-binding domain; Region: Haem_bd; pfam14376 383372000651 ApbE family; Region: ApbE; cl00643 383372000652 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 383372000653 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 383372000654 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 383372000655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372000656 active site 383372000657 phosphorylation site [posttranslational modification] 383372000658 intermolecular recognition site; other site 383372000659 dimerization interface [polypeptide binding]; other site 383372000660 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 383372000661 DNA binding site [nucleotide binding] 383372000662 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372000663 dimer interface [polypeptide binding]; other site 383372000664 phosphorylation site [posttranslational modification] 383372000665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372000666 ATP binding site [chemical binding]; other site 383372000667 Mg2+ binding site [ion binding]; other site 383372000668 G-X-G motif; other site 383372000669 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 383372000670 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 383372000671 oligomer interface [polypeptide binding]; other site 383372000672 active site 383372000673 metal binding site [ion binding]; metal-binding site 383372000674 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 383372000675 Proline racemase; Region: Pro_racemase; pfam05544 383372000676 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 383372000677 Glyco_18 domain; Region: Glyco_18; smart00636 383372000678 active site 383372000679 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 383372000680 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 383372000681 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 383372000682 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 383372000683 DNA binding residues [nucleotide binding] 383372000684 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 383372000685 PhoU domain; Region: PhoU; pfam01895 383372000686 PhoU domain; Region: PhoU; pfam01895 383372000687 Acylphosphatase; Region: Acylphosphatase; cl00551 383372000688 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 383372000689 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 383372000690 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 383372000691 active site 383372000692 Response regulator receiver domain; Region: Response_reg; pfam00072 383372000693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372000694 active site 383372000695 phosphorylation site [posttranslational modification] 383372000696 intermolecular recognition site; other site 383372000697 dimerization interface [polypeptide binding]; other site 383372000698 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372000699 dimer interface [polypeptide binding]; other site 383372000700 phosphorylation site [posttranslational modification] 383372000701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372000702 ATP binding site [chemical binding]; other site 383372000703 Mg2+ binding site [ion binding]; other site 383372000704 G-X-G motif; other site 383372000705 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 383372000706 Fe-S cluster binding site [ion binding]; other site 383372000707 active site 383372000708 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 383372000709 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 383372000710 active site 383372000711 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 383372000712 Zn binding site [ion binding]; other site 383372000713 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 383372000714 ligand binding site [chemical binding]; other site 383372000715 flexible hinge region; other site 383372000716 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 383372000717 4Fe-4S binding domain; Region: Fer4; cl02805 383372000718 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 383372000719 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 383372000720 Zn2+ binding site [ion binding]; other site 383372000721 Mg2+ binding site [ion binding]; other site 383372000722 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 383372000723 DNA primase; Validated; Region: dnaG; PRK05667 383372000724 CHC2 zinc finger; Region: zf-CHC2; cl15369 383372000725 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 383372000726 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 383372000727 active site 383372000728 metal binding site [ion binding]; metal-binding site 383372000729 interdomain interaction site; other site 383372000730 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 383372000731 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 383372000732 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 383372000733 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 383372000734 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 383372000735 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 383372000736 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 383372000737 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 383372000738 DNA binding residues [nucleotide binding] 383372000739 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 383372000740 HSP70 interaction site [polypeptide binding]; other site 383372000741 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 383372000742 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 383372000743 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 383372000744 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 383372000745 GTP binding site; other site 383372000746 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 383372000747 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372000748 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 383372000749 putative L-serine binding site [chemical binding]; other site 383372000750 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 383372000751 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 383372000752 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 383372000753 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 383372000754 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 383372000755 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 383372000756 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 383372000757 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 383372000758 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 383372000759 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 383372000760 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 383372000761 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 383372000762 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 383372000763 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 383372000764 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 383372000765 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 383372000766 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 383372000767 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 383372000768 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 383372000769 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 383372000770 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 383372000771 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 383372000772 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 383372000773 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 383372000774 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 383372000775 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 383372000776 FtsX-like permease family; Region: FtsX; cl15850 383372000777 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 383372000778 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 383372000779 Walker A/P-loop; other site 383372000780 ATP binding site [chemical binding]; other site 383372000781 Q-loop/lid; other site 383372000782 ABC transporter signature motif; other site 383372000783 Walker B; other site 383372000784 D-loop; other site 383372000785 H-loop/switch region; other site 383372000786 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 383372000787 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 383372000788 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 383372000789 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 383372000790 Helix-turn-helix domains; Region: HTH; cl00088 383372000791 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 383372000792 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 383372000793 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 383372000794 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 383372000795 NAD(P) binding site [chemical binding]; other site 383372000796 catalytic residues [active] 383372000797 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 383372000798 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 383372000799 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 383372000800 non-specific DNA binding site [nucleotide binding]; other site 383372000801 salt bridge; other site 383372000802 sequence-specific DNA binding site [nucleotide binding]; other site 383372000803 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 383372000804 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 383372000805 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 383372000806 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 383372000807 RNA binding surface [nucleotide binding]; other site 383372000808 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 383372000809 active site 383372000810 malate dehydrogenase; Reviewed; Region: PRK06223 383372000811 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 383372000812 NAD(P) binding site [chemical binding]; other site 383372000813 dimer interface [polypeptide binding]; other site 383372000814 tetramer (dimer of dimers) interface [polypeptide binding]; other site 383372000815 substrate binding site [chemical binding]; other site 383372000816 GAF domain; Region: GAF; cl15785 383372000817 Histidine kinase; Region: HisKA_3; pfam07730 383372000818 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372000819 ATP binding site [chemical binding]; other site 383372000820 Mg2+ binding site [ion binding]; other site 383372000821 G-X-G motif; other site 383372000822 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372000823 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 383372000824 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 383372000825 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 383372000826 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 383372000827 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 383372000828 putative active site [active] 383372000829 putative metal binding site [ion binding]; other site 383372000830 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 383372000831 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 383372000832 catalytic core [active] 383372000833 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 383372000834 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 383372000835 ligand binding site [chemical binding]; other site 383372000836 flexible hinge region; other site 383372000837 Helix-turn-helix domains; Region: HTH; cl00088 383372000838 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 383372000839 TIGR03663 family protein; Region: TIGR03663 383372000840 Conjugate Transporter-2 (CT2) Family protein; Region: 3a01208; TIGR00958 383372000841 TIGR03663 family protein; Region: TIGR03663 383372000842 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 383372000843 NHL repeat; Region: NHL; pfam01436 383372000844 Uncharacterized conserved protein [Function unknown]; Region: COG3391 383372000845 NHL repeat; Region: NHL; pfam01436 383372000846 NHL repeat; Region: NHL; pfam01436 383372000847 NHL repeat; Region: NHL; pfam01436 383372000848 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 383372000849 metal-binding site [ion binding] 383372000850 multifunctional aminopeptidase A; Provisional; Region: PRK00913 383372000851 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 383372000852 interface (dimer of trimers) [polypeptide binding]; other site 383372000853 Substrate-binding/catalytic site; other site 383372000854 Zn-binding sites [ion binding]; other site 383372000855 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 383372000856 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 383372000857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372000858 active site 383372000859 phosphorylation site [posttranslational modification] 383372000860 intermolecular recognition site; other site 383372000861 dimerization interface [polypeptide binding]; other site 383372000862 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 383372000863 Zn2+ binding site [ion binding]; other site 383372000864 Mg2+ binding site [ion binding]; other site 383372000865 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 383372000866 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 383372000867 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372000868 homodimer interface [polypeptide binding]; other site 383372000869 catalytic residue [active] 383372000870 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 383372000871 active site 383372000872 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 383372000873 active site 383372000874 GTP cyclohydrolase I; Provisional; Region: PLN03044 383372000875 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 383372000876 homodecamer interface [polypeptide binding]; other site 383372000877 active site 383372000878 putative catalytic site residues [active] 383372000879 zinc binding site [ion binding]; other site 383372000880 GTP-CH-I/GFRP interaction surface; other site 383372000881 classical (c) SDRs; Region: SDR_c; cd05233 383372000882 NAD(P) binding site [chemical binding]; other site 383372000883 active site 383372000884 Predicted transcriptional regulator [Transcription]; Region: COG2345 383372000885 Helix-turn-helix domains; Region: HTH; cl00088 383372000886 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 383372000887 FeS assembly ATPase SufC; Region: sufC; TIGR01978 383372000888 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 383372000889 Walker A/P-loop; other site 383372000890 ATP binding site [chemical binding]; other site 383372000891 Q-loop/lid; other site 383372000892 ABC transporter signature motif; other site 383372000893 Walker B; other site 383372000894 D-loop; other site 383372000895 H-loop/switch region; other site 383372000896 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 383372000897 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 383372000898 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 383372000899 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 383372000900 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 383372000901 catalytic residue [active] 383372000902 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 383372000903 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 383372000904 trimerization site [polypeptide binding]; other site 383372000905 active site 383372000906 FeS assembly protein SufB; Region: sufB; TIGR01980 383372000907 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 383372000908 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 383372000909 [2Fe-2S] cluster binding site [ion binding]; other site 383372000910 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 383372000911 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 383372000912 active site residue [active] 383372000913 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 383372000914 active site residue [active] 383372000915 Fe-S metabolism associated domain; Region: SufE; cl00951 383372000916 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 383372000917 trimerization site [polypeptide binding]; other site 383372000918 active site 383372000919 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 383372000920 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 383372000921 dimer interface [polypeptide binding]; other site 383372000922 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372000923 catalytic residue [active] 383372000924 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 383372000925 MPN+ (JAMM) motif; other site 383372000926 Zinc-binding site [ion binding]; other site 383372000927 Ubiquitin-like proteins; Region: UBQ; cl00155 383372000928 charged pocket; other site 383372000929 hydrophobic patch; other site 383372000930 hypothetical protein; Validated; Region: PRK07411 383372000931 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 383372000932 ATP binding site [chemical binding]; other site 383372000933 substrate interface [chemical binding]; other site 383372000934 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 383372000935 active site residue [active] 383372000936 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 383372000937 peptide binding site [polypeptide binding]; other site 383372000938 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 383372000939 dimer interface [polypeptide binding]; other site 383372000940 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 383372000941 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 383372000942 active site residue [active] 383372000943 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 383372000944 active site residue [active] 383372000945 isoleucyl-tRNA synthetase; Region: ileS; TIGR00392 383372000946 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 383372000947 active site 383372000948 HIGH motif; other site 383372000949 nucleotide binding site [chemical binding]; other site 383372000950 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 383372000951 active site 383372000952 KMSKS motif; other site 383372000953 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 383372000954 tRNA binding surface [nucleotide binding]; other site 383372000955 anticodon binding site; other site 383372000956 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 383372000957 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 383372000958 DNA gyrase subunit A; Validated; Region: PRK05560 383372000959 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 383372000960 CAP-like domain; other site 383372000961 active site 383372000962 primary dimer interface [polypeptide binding]; other site 383372000963 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 383372000964 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 383372000965 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 383372000966 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 383372000967 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 383372000968 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 383372000969 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 383372000970 active site 383372000971 metal binding site [ion binding]; metal-binding site 383372000972 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 383372000973 Active Sites [active] 383372000974 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 383372000975 active site 383372000976 pantoate--beta-alanine ligase; Region: panC; TIGR00018 383372000977 Pantoate-beta-alanine ligase; Region: PanC; cd00560 383372000978 active site 383372000979 ATP-binding site [chemical binding]; other site 383372000980 pantoate-binding site; other site 383372000981 HXXH motif; other site 383372000982 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 383372000983 oligomerization interface [polypeptide binding]; other site 383372000984 active site 383372000985 metal binding site [ion binding]; metal-binding site 383372000986 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 383372000987 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 383372000988 Catalytic domain of Protein Kinases; Region: PKc; cd00180 383372000989 active site 383372000990 ATP binding site [chemical binding]; other site 383372000991 substrate binding site [chemical binding]; other site 383372000992 activation loop (A-loop); other site 383372000993 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 383372000994 Bacterial transcriptional activator domain; Region: BTAD; smart01043 383372000995 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372000996 Predicted ATPase [General function prediction only]; Region: COG3899 383372000997 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 383372000998 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 383372000999 putative GEF interaction site [polypeptide binding]; other site 383372001000 G1 box; other site 383372001001 GTP/Mg2+ binding site [chemical binding]; other site 383372001002 Switch I region; other site 383372001003 G2 box; other site 383372001004 G3 box; other site 383372001005 Switch II region; other site 383372001006 G4 box; other site 383372001007 G5 box; other site 383372001008 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 383372001009 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 383372001010 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 383372001011 acyl-CoA binding pocket [chemical binding]; other site 383372001012 CoA binding site [chemical binding]; other site 383372001013 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 383372001014 active site 383372001015 dimer interface [polypeptide binding]; other site 383372001016 catalytic nucleophile [active] 383372001017 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 383372001018 Protein of unknown function (DUF4013); Region: DUF4013; pfam13197 383372001019 Protein of unknown function (DUF4013); Region: DUF4013; pfam13197 383372001020 competence damage-inducible protein A; Provisional; Region: PRK00549 383372001021 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 383372001022 putative MPT binding site; other site 383372001023 Competence-damaged protein; Region: CinA; cl00666 383372001024 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 383372001025 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 383372001026 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 383372001027 active site 383372001028 dimer interface [polypeptide binding]; other site 383372001029 motif 1; other site 383372001030 motif 2; other site 383372001031 motif 3; other site 383372001032 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 383372001033 anticodon binding site; other site 383372001034 Domain of unknown function (DUF4212); Region: DUF4212; cl01781 383372001035 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 383372001036 Sodium:solute symporter family; Region: SSF; cl00456 383372001037 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 383372001038 dimerization interface [polypeptide binding]; other site 383372001039 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372001040 dimer interface [polypeptide binding]; other site 383372001041 phosphorylation site [posttranslational modification] 383372001042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372001043 ATP binding site [chemical binding]; other site 383372001044 Mg2+ binding site [ion binding]; other site 383372001045 G-X-G motif; other site 383372001046 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 383372001047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372001048 active site 383372001049 phosphorylation site [posttranslational modification] 383372001050 intermolecular recognition site; other site 383372001051 dimerization interface [polypeptide binding]; other site 383372001052 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 383372001053 DNA binding site [nucleotide binding] 383372001054 Bifunctional nuclease; Region: DNase-RNase; cl00553 383372001055 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 383372001056 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 383372001057 P-loop; other site 383372001058 Magnesium ion binding site [ion binding]; other site 383372001059 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 383372001060 Magnesium ion binding site [ion binding]; other site 383372001061 ParB-like partition proteins; Region: parB_part; TIGR00180 383372001062 ParB-like nuclease domain; Region: ParBc; cl02129 383372001063 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 383372001064 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 383372001065 substrate binding site [chemical binding]; other site 383372001066 ATP binding site [chemical binding]; other site 383372001067 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 383372001068 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 383372001069 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 383372001070 Walker A/P-loop; other site 383372001071 ATP binding site [chemical binding]; other site 383372001072 Q-loop/lid; other site 383372001073 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 383372001074 ABC transporter signature motif; other site 383372001075 Walker B; other site 383372001076 D-loop; other site 383372001077 H-loop/switch region; other site 383372001078 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 383372001079 O-Antigen ligase; Region: Wzy_C; cl04850 383372001080 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 383372001081 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372001082 TPR motif; other site 383372001083 binding surface 383372001084 Membrane transport protein; Region: Mem_trans; cl09117 383372001085 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 383372001086 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 383372001087 DctM-like transporters; Region: DctM; pfam06808 383372001088 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 383372001089 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 383372001090 active site 383372001091 HIGH motif; other site 383372001092 nucleotide binding site [chemical binding]; other site 383372001093 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 383372001094 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 383372001095 active site 383372001096 KMSKS motif; other site 383372001097 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 383372001098 tRNA binding surface [nucleotide binding]; other site 383372001099 anticodon binding site; other site 383372001100 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 383372001101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372001102 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 383372001103 NAD(P) binding site [chemical binding]; other site 383372001104 active site 383372001105 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 383372001106 MviN-like protein; Region: MVIN; pfam03023 383372001107 bile acid transporter; Region: bass; TIGR00841 383372001108 Membrane transport protein; Region: Mem_trans; cl09117 383372001109 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 383372001110 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 383372001111 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 383372001112 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 383372001113 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 383372001114 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 383372001115 Ezrin/radixin/moesin family; Region: ERM; pfam00769 383372001116 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 383372001117 Response regulator receiver domain; Region: Response_reg; pfam00072 383372001118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372001119 active site 383372001120 phosphorylation site [posttranslational modification] 383372001121 intermolecular recognition site; other site 383372001122 dimerization interface [polypeptide binding]; other site 383372001123 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 383372001124 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 383372001125 Probable Catalytic site; other site 383372001126 metal-binding site 383372001127 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 383372001128 putative metal binding site; other site 383372001129 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 383372001130 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 383372001131 Probable Catalytic site; other site 383372001132 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 383372001133 Catalytic domain of Protein Kinases; Region: PKc; cd00180 383372001134 active site 383372001135 ATP binding site [chemical binding]; other site 383372001136 substrate binding site [chemical binding]; other site 383372001137 activation loop (A-loop); other site 383372001138 TPR repeat; Region: TPR_11; pfam13414 383372001139 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372001140 binding surface 383372001141 TPR motif; other site 383372001142 TPR repeat; Region: TPR_11; pfam13414 383372001143 TPR repeat; Region: TPR_11; pfam13414 383372001144 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372001145 binding surface 383372001146 TPR motif; other site 383372001147 TPR repeat; Region: TPR_11; pfam13414 383372001148 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 383372001149 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 383372001150 dimer interface [polypeptide binding]; other site 383372001151 active site 383372001152 ribonuclease III; Reviewed; Region: rnc; PRK00102 383372001153 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 383372001154 dimerization interface [polypeptide binding]; other site 383372001155 active site 383372001156 metal binding site [ion binding]; metal-binding site 383372001157 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 383372001158 dsRNA binding site [nucleotide binding]; other site 383372001159 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 383372001160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372001161 NAD(P) binding site [chemical binding]; other site 383372001162 active site 383372001163 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 383372001164 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 383372001165 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 383372001166 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 383372001167 peptide binding site [polypeptide binding]; other site 383372001168 dimer interface [polypeptide binding]; other site 383372001169 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 383372001170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372001171 dimer interface [polypeptide binding]; other site 383372001172 conserved gate region; other site 383372001173 putative PBP binding loops; other site 383372001174 ABC-ATPase subunit interface; other site 383372001175 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 383372001176 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 383372001177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372001178 dimer interface [polypeptide binding]; other site 383372001179 conserved gate region; other site 383372001180 putative PBP binding loops; other site 383372001181 ABC-ATPase subunit interface; other site 383372001182 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 383372001183 Catalytic domain of Protein Kinases; Region: PKc; cd00180 383372001184 active site 383372001185 ATP binding site [chemical binding]; other site 383372001186 substrate binding site [chemical binding]; other site 383372001187 activation loop (A-loop); other site 383372001188 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 383372001189 EBNA-3B; Provisional; Region: PHA03378 383372001190 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 383372001191 nudix motif; other site 383372001192 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 383372001193 Isochorismatase family; Region: Isochorismatase; pfam00857 383372001194 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 383372001195 catalytic triad [active] 383372001196 conserved cis-peptide bond; other site 383372001197 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 383372001198 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372001199 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 383372001200 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 383372001201 Helix-turn-helix domains; Region: HTH; cl00088 383372001202 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 383372001203 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 383372001204 substrate-Mg2+ binding site; other site 383372001205 substrate binding pocket [chemical binding]; other site 383372001206 aspartate-rich region 1; other site 383372001207 aspartate-rich region 2; other site 383372001208 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 383372001209 active site 383372001210 catalytic site [active] 383372001211 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 383372001212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372001213 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 383372001214 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 383372001215 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 383372001216 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372001217 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372001218 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 383372001219 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372001220 ATP binding site [chemical binding]; other site 383372001221 putative Mg++ binding site [ion binding]; other site 383372001222 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 383372001223 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 383372001224 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 383372001225 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372001226 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 383372001227 Restriction endonuclease BsobI; Region: Endonuc-BsobI; pfam09194 383372001228 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 383372001229 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 383372001230 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 383372001231 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 383372001232 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 383372001233 AMP-binding enzyme; Region: AMP-binding; cl15778 383372001234 AMP-binding enzyme; Region: AMP-binding; cl15778 383372001235 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 383372001236 AMP-binding enzyme; Region: AMP-binding; cl15778 383372001237 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 383372001238 transketolase; Reviewed; Region: PRK05899 383372001239 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 383372001240 TPP-binding site [chemical binding]; other site 383372001241 dimer interface [polypeptide binding]; other site 383372001242 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 383372001243 PYR/PP interface [polypeptide binding]; other site 383372001244 dimer interface [polypeptide binding]; other site 383372001245 TPP binding site [chemical binding]; other site 383372001246 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 383372001247 active site 383372001248 intersubunit interactions; other site 383372001249 catalytic residue [active] 383372001250 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 383372001251 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 383372001252 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 383372001253 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 383372001254 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 383372001255 DNA binding residues [nucleotide binding] 383372001256 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 383372001257 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372001258 Walker A/P-loop; other site 383372001259 ATP binding site [chemical binding]; other site 383372001260 Q-loop/lid; other site 383372001261 ABC transporter signature motif; other site 383372001262 Walker B; other site 383372001263 D-loop; other site 383372001264 H-loop/switch region; other site 383372001265 ABC-2 type transporter; Region: ABC2_membrane; cl11417 383372001266 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 383372001267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372001268 active site 383372001269 phosphorylation site [posttranslational modification] 383372001270 intermolecular recognition site; other site 383372001271 dimerization interface [polypeptide binding]; other site 383372001272 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 383372001273 DNA binding site [nucleotide binding] 383372001274 Response regulator receiver domain; Region: Response_reg; pfam00072 383372001275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372001276 active site 383372001277 phosphorylation site [posttranslational modification] 383372001278 intermolecular recognition site; other site 383372001279 dimerization interface [polypeptide binding]; other site 383372001280 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 383372001281 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372001282 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372001283 FG-GAP repeat; Region: FG-GAP; cl15299 383372001284 FG-GAP repeat; Region: FG-GAP; cl15299 383372001285 FG-GAP repeat; Region: FG-GAP; cl15299 383372001286 FG-GAP repeat; Region: FG-GAP; cl15299 383372001287 FG-GAP repeat; Region: FG-GAP; cl15299 383372001288 FG-GAP repeat; Region: FG-GAP; cl15299 383372001289 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372001290 AAA domain; Region: AAA_22; pfam13401 383372001291 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 383372001292 putative ADP-ribose binding site [chemical binding]; other site 383372001293 putative active site [active] 383372001294 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 383372001295 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 383372001296 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 383372001297 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 383372001298 trimer interface [polypeptide binding]; other site 383372001299 active site 383372001300 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 383372001301 active site 383372001302 Ap6A binding site [chemical binding]; other site 383372001303 nudix motif; other site 383372001304 metal binding site [ion binding]; metal-binding site 383372001305 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 383372001306 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 383372001307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372001308 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372001309 putative active site [active] 383372001310 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 383372001311 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 383372001312 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 383372001313 catalytic triad [active] 383372001314 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 383372001315 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 383372001316 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 383372001317 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 383372001318 Integral membrane protein TerC family; Region: TerC; cl10468 383372001319 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 383372001320 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 383372001321 GDP-binding site [chemical binding]; other site 383372001322 ACT binding site; other site 383372001323 IMP binding site; other site 383372001324 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 383372001325 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 383372001326 P-loop; other site 383372001327 Magnesium ion binding site [ion binding]; other site 383372001328 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 383372001329 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 383372001330 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 383372001331 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 383372001332 active site 383372001333 motif I; other site 383372001334 motif II; other site 383372001335 Chain length determinant protein; Region: Wzz; cl15801 383372001336 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 383372001337 Chain length determinant protein; Region: Wzz; cl15801 383372001338 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 383372001339 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 383372001340 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 383372001341 putative trimer interface [polypeptide binding]; other site 383372001342 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 383372001343 trimer interface [polypeptide binding]; other site 383372001344 active site 383372001345 substrate binding site [chemical binding]; other site 383372001346 putative CoA binding site [chemical binding]; other site 383372001347 CoA binding site [chemical binding]; other site 383372001348 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 383372001349 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 383372001350 Ligand binding site; other site 383372001351 Putative Catalytic site; other site 383372001352 DXD motif; other site 383372001353 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 383372001354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 383372001355 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 383372001356 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 383372001357 B12 binding site [chemical binding]; other site 383372001358 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 383372001359 FeS/SAM binding site; other site 383372001360 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 383372001361 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 383372001362 MatE; Region: MatE; cl10513 383372001363 colanic acid exporter; Provisional; Region: PRK10459 383372001364 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 383372001365 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 383372001366 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 383372001367 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 383372001368 Probable Catalytic site; other site 383372001369 metal-binding site 383372001370 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 383372001371 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 383372001372 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 383372001373 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 383372001374 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 383372001375 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 383372001376 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 383372001377 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 383372001378 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 383372001379 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 383372001380 Probable Catalytic site; other site 383372001381 metal-binding site 383372001382 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 383372001383 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 383372001384 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl01922 383372001385 Asp-box motif; other site 383372001386 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 383372001387 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 383372001388 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 383372001389 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 383372001390 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 383372001391 active site 383372001392 Fibronectin type III-like domain; Region: Fn3-like; cl15273 383372001393 Fibronectin type III-like domain; Region: Fn3-like; cl15273 383372001394 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 383372001395 Restriction endonuclease; Region: Mrr_cat; cl00516 383372001396 Bacterial SH3 domain; Region: SH3_3; cl02551 383372001397 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 383372001398 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14668 383372001399 Transcriptional regulators [Transcription]; Region: MarR; COG1846 383372001400 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 383372001401 non-specific DNA interactions [nucleotide binding]; other site 383372001402 DNA binding site [nucleotide binding] 383372001403 sequence specific DNA binding site [nucleotide binding]; other site 383372001404 putative cAMP binding site [chemical binding]; other site 383372001405 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 383372001406 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 383372001407 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 383372001408 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 383372001409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372001410 dimer interface [polypeptide binding]; other site 383372001411 conserved gate region; other site 383372001412 putative PBP binding loops; other site 383372001413 ABC-ATPase subunit interface; other site 383372001414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372001415 dimer interface [polypeptide binding]; other site 383372001416 conserved gate region; other site 383372001417 putative PBP binding loops; other site 383372001418 ABC-ATPase subunit interface; other site 383372001419 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 383372001420 putative ligand binding site [chemical binding]; other site 383372001421 classical (c) SDRs; Region: SDR_c; cd05233 383372001422 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 383372001423 NAD(P) binding site [chemical binding]; other site 383372001424 active site 383372001425 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372001426 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 383372001427 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 383372001428 NAD(P) binding site [chemical binding]; other site 383372001429 homodimer interface [polypeptide binding]; other site 383372001430 substrate binding site [chemical binding]; other site 383372001431 active site 383372001432 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 383372001433 putative active site [active] 383372001434 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 383372001435 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 383372001436 inhibitor-cofactor binding pocket; inhibition site 383372001437 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372001438 catalytic residue [active] 383372001439 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 383372001440 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 383372001441 homodimer interface [polypeptide binding]; other site 383372001442 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 383372001443 NAD binding pocket [chemical binding]; other site 383372001444 ATP binding pocket [chemical binding]; other site 383372001445 Mg binding site [ion binding]; other site 383372001446 active-site loop [active] 383372001447 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 383372001448 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 383372001449 active site 383372001450 dimer interface [polypeptide binding]; other site 383372001451 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 383372001452 Ligand Binding Site [chemical binding]; other site 383372001453 Molecular Tunnel; other site 383372001454 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 383372001455 AMP-binding enzyme; Region: AMP-binding; cl15778 383372001456 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 383372001457 Phosphopantetheine attachment site; Region: PP-binding; cl09936 383372001458 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 383372001459 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 383372001460 Bacterial sugar transferase; Region: Bac_transf; cl00939 383372001461 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 383372001462 putative ADP-binding pocket [chemical binding]; other site 383372001463 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 383372001464 MatE; Region: MatE; cl10513 383372001465 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 383372001466 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 383372001467 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 383372001468 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 383372001469 Chain length determinant protein; Region: Wzz; cl15801 383372001470 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 383372001471 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 383372001472 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 383372001473 active site 383372001474 metal binding site [ion binding]; metal-binding site 383372001475 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 383372001476 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 383372001477 Transglycosylase; Region: Transgly; cl07896 383372001478 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 383372001479 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 383372001480 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 383372001481 Catalytic domain of Protein Kinases; Region: PKc; cd00180 383372001482 active site 383372001483 ATP binding site [chemical binding]; other site 383372001484 substrate binding site [chemical binding]; other site 383372001485 activation loop (A-loop); other site 383372001486 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 383372001487 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 383372001488 DNA binding site [nucleotide binding] 383372001489 active site 383372001490 Transcriptional regulators [Transcription]; Region: PurR; COG1609 383372001491 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 383372001492 DNA binding site [nucleotide binding] 383372001493 domain linker motif; other site 383372001494 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 383372001495 putative dimerization interface [polypeptide binding]; other site 383372001496 putative ligand binding site [chemical binding]; other site 383372001497 PQQ-like domain; Region: PQQ_2; pfam13360 383372001498 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 383372001499 active site 383372001500 Trp docking motif [polypeptide binding]; other site 383372001501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372001502 dimer interface [polypeptide binding]; other site 383372001503 conserved gate region; other site 383372001504 putative PBP binding loops; other site 383372001505 ABC-ATPase subunit interface; other site 383372001506 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 383372001507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372001508 dimer interface [polypeptide binding]; other site 383372001509 conserved gate region; other site 383372001510 putative PBP binding loops; other site 383372001511 ABC-ATPase subunit interface; other site 383372001512 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 383372001513 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 383372001514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 383372001515 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 383372001516 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372001517 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 383372001518 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 383372001519 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 383372001520 putative active site [active] 383372001521 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 383372001522 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372001523 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 383372001524 Formate--tetrahydrofolate ligase; Region: FTHFS; pfam01268 383372001525 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 383372001526 Potassium binding sites [ion binding]; other site 383372001527 Cesium cation binding sites [ion binding]; other site 383372001528 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 383372001529 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 383372001530 active site 383372001531 metal binding site [ion binding]; metal-binding site 383372001532 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 383372001533 Predicted esterase [General function prediction only]; Region: COG0627 383372001534 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 383372001535 Catalytic domain of Protein Kinases; Region: PKc; cd00180 383372001536 active site 383372001537 ATP binding site [chemical binding]; other site 383372001538 substrate binding site [chemical binding]; other site 383372001539 activation loop (A-loop); other site 383372001540 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372001541 binding surface 383372001542 TPR motif; other site 383372001543 Tetratricopeptide repeat; Region: TPR_12; pfam13424 383372001544 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372001545 binding surface 383372001546 TPR motif; other site 383372001547 TPR repeat; Region: TPR_11; pfam13414 383372001548 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372001549 binding surface 383372001550 TPR motif; other site 383372001551 TPR repeat; Region: TPR_11; pfam13414 383372001552 MFS_1 like family; Region: MFS_1_like; pfam12832 383372001553 sugar efflux transporter; Region: 2A0120; TIGR00899 383372001554 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 383372001555 putative substrate translocation pore; other site 383372001556 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 383372001557 active site 383372001558 catalytic triad [active] 383372001559 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 383372001560 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 383372001561 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 383372001562 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372001563 Walker A/P-loop; other site 383372001564 ATP binding site [chemical binding]; other site 383372001565 Q-loop/lid; other site 383372001566 ABC transporter signature motif; other site 383372001567 Walker B; other site 383372001568 D-loop; other site 383372001569 H-loop/switch region; other site 383372001570 Uncharacterized membrane protein (DUF2298); Region: DUF2298; cl02250 383372001571 Uncharacterized membrane protein (DUF2298); Region: DUF2298; cl02250 383372001572 Uncharacterized membrane protein (DUF2298); Region: DUF2298; cl02250 383372001573 Uncharacterized membrane protein (DUF2298); Region: DUF2298; cl02250 383372001574 Uncharacterized membrane protein (DUF2298); Region: DUF2298; cl02250 383372001575 Uncharacterized membrane protein (DUF2298); Region: DUF2298; cl02250 383372001576 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372001577 TPR motif; other site 383372001578 Tetratricopeptide repeat; Region: TPR_16; pfam13432 383372001579 binding surface 383372001580 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372001581 TPR motif; other site 383372001582 binding surface 383372001583 TPR repeat; Region: TPR_11; pfam13414 383372001584 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 383372001585 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 383372001586 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 383372001587 Protein of unknown function (DUF433); Region: DUF433; cl01030 383372001588 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 383372001589 AMP-binding enzyme; Region: AMP-binding; cl15778 383372001590 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 383372001591 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 383372001592 Walker A/P-loop; other site 383372001593 ATP binding site [chemical binding]; other site 383372001594 Q-loop/lid; other site 383372001595 ABC transporter signature motif; other site 383372001596 Walker B; other site 383372001597 D-loop; other site 383372001598 H-loop/switch region; other site 383372001599 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 383372001600 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 383372001601 putative ligand binding site [chemical binding]; other site 383372001602 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 383372001603 TM-ABC transporter signature motif; other site 383372001604 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 383372001605 TM-ABC transporter signature motif; other site 383372001606 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 383372001607 AMP-binding enzyme; Region: AMP-binding; cl15778 383372001608 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 383372001609 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 383372001610 Walker A/P-loop; other site 383372001611 ATP binding site [chemical binding]; other site 383372001612 Q-loop/lid; other site 383372001613 ABC transporter signature motif; other site 383372001614 Walker B; other site 383372001615 D-loop; other site 383372001616 H-loop/switch region; other site 383372001617 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 383372001618 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 383372001619 active site 383372001620 endonuclease IV; Provisional; Region: PRK01060 383372001621 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 383372001622 AP (apurinic/apyrimidinic) site pocket; other site 383372001623 DNA interaction; other site 383372001624 Metal-binding active site; metal-binding site 383372001625 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 383372001626 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 383372001627 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 383372001628 ATP-grasp domain; Region: ATP-grasp_4; cl03087 383372001629 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 383372001630 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 383372001631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372001632 S-adenosylmethionine binding site [chemical binding]; other site 383372001633 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372001634 putative active site [active] 383372001635 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 383372001636 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 383372001637 dimer interface [polypeptide binding]; other site 383372001638 active site 383372001639 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 383372001640 substrate binding site [chemical binding]; other site 383372001641 catalytic residue [active] 383372001642 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 383372001643 active site 383372001644 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 383372001645 active site 383372001646 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 383372001647 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 383372001648 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 383372001649 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 383372001650 RNA binding surface [nucleotide binding]; other site 383372001651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 383372001652 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 383372001653 CoA-transferase family III; Region: CoA_transf_3; pfam02515 383372001654 malonyl-CoA synthase; Validated; Region: PRK07514 383372001655 AMP-binding enzyme; Region: AMP-binding; cl15778 383372001656 AMP-binding enzyme; Region: AMP-binding; cl15778 383372001657 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 383372001658 FAD binding domain; Region: FAD_binding_4; pfam01565 383372001659 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 383372001660 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 383372001661 Cysteine-rich domain; Region: CCG; pfam02754 383372001662 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 383372001663 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 383372001664 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 383372001665 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 383372001666 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 383372001667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 383372001668 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 383372001669 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372001670 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 383372001671 DNA binding site [nucleotide binding] 383372001672 Domain of unknown function (DUF897); Region: DUF897; cl01312 383372001673 Nitrogen regulatory protein P-II; Region: P-II; cl00412 383372001674 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 383372001675 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 383372001676 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 383372001677 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 383372001678 HEPN domain; Region: HEPN; cl00824 383372001679 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 383372001680 active site 383372001681 NTP binding site [chemical binding]; other site 383372001682 metal binding triad [ion binding]; metal-binding site 383372001683 antibiotic binding site [chemical binding]; other site 383372001684 HEPN domain; Region: HEPN; cl00824 383372001685 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 383372001686 active site 383372001687 NTP binding site [chemical binding]; other site 383372001688 metal binding triad [ion binding]; metal-binding site 383372001689 antibiotic binding site [chemical binding]; other site 383372001690 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 383372001691 Catalytic domain of Protein Kinases; Region: PKc; cd00180 383372001692 active site 383372001693 ATP binding site [chemical binding]; other site 383372001694 substrate binding site [chemical binding]; other site 383372001695 activation loop (A-loop); other site 383372001696 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 383372001697 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 383372001698 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 383372001699 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 383372001700 TPR repeat; Region: TPR_11; pfam13414 383372001701 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372001702 binding surface 383372001703 TPR motif; other site 383372001704 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 383372001705 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 383372001706 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 383372001707 Citrate synthase; Region: Citrate_synt; pfam00285 383372001708 oxalacetate binding site [chemical binding]; other site 383372001709 citrylCoA binding site [chemical binding]; other site 383372001710 coenzyme A binding site [chemical binding]; other site 383372001711 catalytic triad [active] 383372001712 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 383372001713 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 383372001714 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 383372001715 FAD binding site [chemical binding]; other site 383372001716 homotetramer interface [polypeptide binding]; other site 383372001717 substrate binding pocket [chemical binding]; other site 383372001718 catalytic base [active] 383372001719 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 383372001720 PhoU domain; Region: PhoU; pfam01895 383372001721 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 383372001722 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 383372001723 Walker A/P-loop; other site 383372001724 ATP binding site [chemical binding]; other site 383372001725 Q-loop/lid; other site 383372001726 ABC transporter signature motif; other site 383372001727 Walker B; other site 383372001728 D-loop; other site 383372001729 H-loop/switch region; other site 383372001730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372001731 dimer interface [polypeptide binding]; other site 383372001732 conserved gate region; other site 383372001733 putative PBP binding loops; other site 383372001734 ABC-ATPase subunit interface; other site 383372001735 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 383372001736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372001737 dimer interface [polypeptide binding]; other site 383372001738 conserved gate region; other site 383372001739 putative PBP binding loops; other site 383372001740 ABC-ATPase subunit interface; other site 383372001741 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 383372001742 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 383372001743 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 383372001744 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 383372001745 dimerization interface [polypeptide binding]; other site 383372001746 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 383372001747 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 383372001748 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 383372001749 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372001750 dimer interface [polypeptide binding]; other site 383372001751 phosphorylation site [posttranslational modification] 383372001752 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372001753 ATP binding site [chemical binding]; other site 383372001754 G-X-G motif; other site 383372001755 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 383372001756 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372001757 active site 383372001758 phosphorylation site [posttranslational modification] 383372001759 intermolecular recognition site; other site 383372001760 dimerization interface [polypeptide binding]; other site 383372001761 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 383372001762 DNA binding site [nucleotide binding] 383372001763 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 383372001764 active site 383372001765 catalytic residues [active] 383372001766 metal binding site [ion binding]; metal-binding site 383372001767 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 383372001768 active site 383372001769 Trp docking motif [polypeptide binding]; other site 383372001770 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 383372001771 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 383372001772 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 383372001773 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 383372001774 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 383372001775 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 383372001776 generic binding surface II; other site 383372001777 ssDNA binding site; other site 383372001778 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 383372001779 ATP binding site [chemical binding]; other site 383372001780 putative Mg++ binding site [ion binding]; other site 383372001781 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 383372001782 nucleotide binding region [chemical binding]; other site 383372001783 ATP-binding site [chemical binding]; other site 383372001784 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 383372001785 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 383372001786 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 383372001787 DAK2 domain; Region: Dak2; cl03685 383372001788 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 383372001789 Asp23 family; Region: Asp23; cl00574 383372001790 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 383372001791 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 383372001792 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 383372001793 active site 383372001794 motif I; other site 383372001795 motif II; other site 383372001796 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 383372001797 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372001798 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 383372001799 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 383372001800 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 383372001801 NAD(P) binding site [chemical binding]; other site 383372001802 catalytic residues [active] 383372001803 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 383372001804 Bacterial Ig-like domain; Region: Big_5; cl01012 383372001805 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372001806 putative active site [active] 383372001807 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 383372001808 active site 383372001809 Int/Topo IB signature motif; other site 383372001810 PemK-like protein; Region: PemK; cl00995 383372001811 Mrr N-terminal domain; Region: Mrr_N; pfam14338 383372001812 EamA-like transporter family; Region: EamA; cl01037 383372001813 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 383372001814 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 383372001815 substrate binding pocket [chemical binding]; other site 383372001816 substrate-Mg2+ binding site; other site 383372001817 aspartate-rich region 1; other site 383372001818 aspartate-rich region 2; other site 383372001819 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 383372001820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372001821 S-adenosylmethionine binding site [chemical binding]; other site 383372001822 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 383372001823 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 383372001824 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 383372001825 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 383372001826 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 383372001827 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 383372001828 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 383372001829 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 383372001830 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 383372001831 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 383372001832 cobyric acid synthase; Provisional; Region: PRK00784 383372001833 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372001834 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 383372001835 catalytic triad [active] 383372001836 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 383372001837 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 383372001838 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372001839 homodimer interface [polypeptide binding]; other site 383372001840 catalytic residue [active] 383372001841 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 383372001842 homotrimer interface [polypeptide binding]; other site 383372001843 Walker A motif; other site 383372001844 GTP binding site [chemical binding]; other site 383372001845 Walker B motif; other site 383372001846 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 383372001847 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 383372001848 catalytic triad [active] 383372001849 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 383372001850 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 383372001851 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 383372001852 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 383372001853 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 383372001854 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 383372001855 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 383372001856 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 383372001857 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372001858 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 383372001859 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 383372001860 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 383372001861 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 383372001862 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 383372001863 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 383372001864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372001865 S-adenosylmethionine binding site [chemical binding]; other site 383372001866 CbiD; Region: CbiD; cl00828 383372001867 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 383372001868 Precorrin-8X methylmutase; Region: CbiC; pfam02570 383372001869 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 383372001870 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 383372001871 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 383372001872 putative active site [active] 383372001873 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 383372001874 putative active site [active] 383372001875 CobD/Cbib protein; Region: CobD_Cbib; cl00561 383372001876 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 383372001877 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 383372001878 Walker A/P-loop; other site 383372001879 ATP binding site [chemical binding]; other site 383372001880 Q-loop/lid; other site 383372001881 ABC transporter signature motif; other site 383372001882 Walker B; other site 383372001883 D-loop; other site 383372001884 H-loop/switch region; other site 383372001885 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 383372001886 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 383372001887 putative dimer interface [polypeptide binding]; other site 383372001888 active site pocket [active] 383372001889 putative cataytic base [active] 383372001890 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 383372001891 dimer interface [polypeptide binding]; other site 383372001892 [2Fe-2S] cluster binding site [ion binding]; other site 383372001893 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 383372001894 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 383372001895 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 383372001896 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 383372001897 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 383372001898 Walker A motif; other site 383372001899 homodimer interface [polypeptide binding]; other site 383372001900 ATP binding site [chemical binding]; other site 383372001901 hydroxycobalamin binding site [chemical binding]; other site 383372001902 Walker B motif; other site 383372001903 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 383372001904 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 383372001905 Walker A/P-loop; other site 383372001906 ATP binding site [chemical binding]; other site 383372001907 Q-loop/lid; other site 383372001908 ABC transporter signature motif; other site 383372001909 Walker B; other site 383372001910 D-loop; other site 383372001911 H-loop/switch region; other site 383372001912 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 383372001913 putative carbohydrate binding site [chemical binding]; other site 383372001914 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372001915 putative active site [active] 383372001916 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 383372001917 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 383372001918 active site 383372001919 metal binding site [ion binding]; metal-binding site 383372001920 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372001921 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 383372001922 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 383372001923 Sulfatase; Region: Sulfatase; cl10460 383372001924 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 383372001925 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 383372001926 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 383372001927 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 383372001928 nucleotide binding region [chemical binding]; other site 383372001929 SEC-C motif; Region: SEC-C; pfam02810 383372001930 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 383372001931 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 383372001932 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 383372001933 Ligand binding site; other site 383372001934 metal-binding site 383372001935 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 383372001936 putative MPT binding site; other site 383372001937 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 383372001938 Domain of unknown function DUF59; Region: DUF59; cl00941 383372001939 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 383372001940 Domain of unknown function DUF77; Region: DUF77; cl00307 383372001941 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 383372001942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372001943 dimer interface [polypeptide binding]; other site 383372001944 conserved gate region; other site 383372001945 putative PBP binding loops; other site 383372001946 ABC-ATPase subunit interface; other site 383372001947 NMT1-like family; Region: NMT1_2; cl15260 383372001948 NMT1/THI5 like; Region: NMT1; pfam09084 383372001949 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 383372001950 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 383372001951 Walker A/P-loop; other site 383372001952 ATP binding site [chemical binding]; other site 383372001953 Q-loop/lid; other site 383372001954 ABC transporter signature motif; other site 383372001955 Walker B; other site 383372001956 D-loop; other site 383372001957 H-loop/switch region; other site 383372001958 Response regulator receiver domain; Region: Response_reg; pfam00072 383372001959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372001960 active site 383372001961 phosphorylation site [posttranslational modification] 383372001962 dimerization interface [polypeptide binding]; other site 383372001963 PAS domain S-box; Region: sensory_box; TIGR00229 383372001964 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 383372001965 putative active site [active] 383372001966 heme pocket [chemical binding]; other site 383372001967 GAF domain; Region: GAF_2; pfam13185 383372001968 GAF domain; Region: GAF; cl15785 383372001969 GAF domain; Region: GAF; cl15785 383372001970 GAF domain; Region: GAF_2; pfam13185 383372001971 Response regulator receiver domain; Region: Response_reg; pfam00072 383372001972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372001973 active site 383372001974 phosphorylation site [posttranslational modification] 383372001975 intermolecular recognition site; other site 383372001976 dimerization interface [polypeptide binding]; other site 383372001977 circadian clock protein KaiC; Reviewed; Region: PRK09302 383372001978 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372001979 Walker A motif; other site 383372001980 ATP binding site [chemical binding]; other site 383372001981 Walker B motif; other site 383372001982 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372001983 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372001984 Walker A motif; other site 383372001985 ATP binding site [chemical binding]; other site 383372001986 Walker B motif; other site 383372001987 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 383372001988 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 383372001989 IHF dimer interface [polypeptide binding]; other site 383372001990 IHF - DNA interface [nucleotide binding]; other site 383372001991 Response regulator receiver domain; Region: Response_reg; pfam00072 383372001992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372001993 active site 383372001994 phosphorylation site [posttranslational modification] 383372001995 intermolecular recognition site; other site 383372001996 dimerization interface [polypeptide binding]; other site 383372001997 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 383372001998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 383372001999 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 383372002000 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 383372002001 nudix motif; other site 383372002002 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 383372002003 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 383372002004 Lamin Tail Domain; Region: LTD; pfam00932 383372002005 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 383372002006 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 383372002007 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 383372002008 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 383372002009 dimer interface [polypeptide binding]; other site 383372002010 putative functional site; other site 383372002011 putative MPT binding site; other site 383372002012 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 383372002013 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 383372002014 FeS/SAM binding site; other site 383372002015 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 383372002016 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372002017 Tetratricopeptide repeat; Region: TPR_12; pfam13424 383372002018 Helix-turn-helix domains; Region: HTH; cl00088 383372002019 DNA binding site [nucleotide binding] 383372002020 Domain of unknown function DUF87; Region: DUF87; pfam01935 383372002021 AAA-like domain; Region: AAA_10; pfam12846 383372002022 NurA domain; Region: NurA; cl09134 383372002023 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 383372002024 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 383372002025 Walker A/P-loop; other site 383372002026 ATP binding site [chemical binding]; other site 383372002027 Q-loop/lid; other site 383372002028 ABC transporter signature motif; other site 383372002029 Walker B; other site 383372002030 D-loop; other site 383372002031 H-loop/switch region; other site 383372002032 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 383372002033 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 383372002034 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 383372002035 Peptidase M16C associated; Region: M16C_assoc; pfam08367 383372002036 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 383372002037 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 383372002038 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 383372002039 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 383372002040 DNA binding residues [nucleotide binding] 383372002041 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 383372002042 AMP-binding enzyme; Region: AMP-binding; cl15778 383372002043 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 383372002044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372002045 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 383372002046 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 383372002047 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372002048 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 383372002049 Bacterial transcriptional activator domain; Region: BTAD; smart01043 383372002050 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 383372002051 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 383372002052 NAD(P) binding site [chemical binding]; other site 383372002053 homotetramer interface [polypeptide binding]; other site 383372002054 homodimer interface [polypeptide binding]; other site 383372002055 active site 383372002056 beta-ketothiolase; Provisional; Region: PRK09051 383372002057 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 383372002058 dimer interface [polypeptide binding]; other site 383372002059 active site 383372002060 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 383372002061 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 383372002062 Coenzyme A binding pocket [chemical binding]; other site 383372002063 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 383372002064 HEPN domain; Region: HEPN; cl00824 383372002065 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 383372002066 active site 383372002067 NTP binding site [chemical binding]; other site 383372002068 metal binding triad [ion binding]; metal-binding site 383372002069 antibiotic binding site [chemical binding]; other site 383372002070 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 383372002071 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 383372002072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372002073 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 383372002074 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 383372002075 active site 383372002076 dimer interface [polypeptide binding]; other site 383372002077 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 383372002078 dimer interface [polypeptide binding]; other site 383372002079 active site 383372002080 Protein of unknown function (DUF433); Region: DUF433; cl01030 383372002081 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 383372002082 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 383372002083 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 383372002084 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 383372002085 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 383372002086 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 383372002087 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 383372002088 Walker A motif; other site 383372002089 ATP binding site [chemical binding]; other site 383372002090 Walker B motif; other site 383372002091 arginine finger; other site 383372002092 Peptidase family M41; Region: Peptidase_M41; pfam01434 383372002093 Transcriptional regulator; Region: Transcrip_reg; cl00361 383372002094 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 383372002095 active site 383372002096 putative DNA-binding cleft [nucleotide binding]; other site 383372002097 dimer interface [polypeptide binding]; other site 383372002098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372002099 S-adenosylmethionine binding site [chemical binding]; other site 383372002100 Domain of unknown function DUF77; Region: DUF77; cl00307 383372002101 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 383372002102 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 383372002103 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 383372002104 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 383372002105 Coenzyme A binding pocket [chemical binding]; other site 383372002106 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 383372002107 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 383372002108 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 383372002109 NAD(P) binding site [chemical binding]; other site 383372002110 ABC-2 type transporter; Region: ABC2_membrane; cl11417 383372002111 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 383372002112 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 383372002113 Walker A/P-loop; other site 383372002114 ATP binding site [chemical binding]; other site 383372002115 Q-loop/lid; other site 383372002116 ABC transporter signature motif; other site 383372002117 Walker B; other site 383372002118 D-loop; other site 383372002119 H-loop/switch region; other site 383372002120 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 383372002121 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 383372002122 Predicted membrane protein [Function unknown]; Region: COG1470 383372002123 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 383372002124 Response regulator receiver domain; Region: Response_reg; pfam00072 383372002125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372002126 active site 383372002127 phosphorylation site [posttranslational modification] 383372002128 intermolecular recognition site; other site 383372002129 dimerization interface [polypeptide binding]; other site 383372002130 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 383372002131 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 383372002132 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 383372002133 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 383372002134 DNA binding residues [nucleotide binding] 383372002135 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 383372002136 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372002137 ATP binding site [chemical binding]; other site 383372002138 Mg2+ binding site [ion binding]; other site 383372002139 G-X-G motif; other site 383372002140 O-Antigen ligase; Region: Wzy_C; cl04850 383372002141 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 383372002142 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 383372002143 tetramer interface [polypeptide binding]; other site 383372002144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372002145 catalytic residue [active] 383372002146 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 383372002147 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 383372002148 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 383372002149 homodimer interface [polypeptide binding]; other site 383372002150 NADP binding site [chemical binding]; other site 383372002151 substrate binding site [chemical binding]; other site 383372002152 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 383372002153 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 383372002154 Substrate binding site; other site 383372002155 Mg++ binding site; other site 383372002156 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 383372002157 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 383372002158 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 383372002159 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 383372002160 active site 383372002161 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 383372002162 Domain of unknown function DUF21; Region: DUF21; pfam01595 383372002163 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 383372002164 Transporter associated domain; Region: CorC_HlyC; cl08393 383372002165 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 383372002166 active site 383372002167 catalytic motif [active] 383372002168 Zn binding site [ion binding]; other site 383372002169 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 383372002170 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 383372002171 active site 383372002172 Substrate binding site; other site 383372002173 Mg++ binding site; other site 383372002174 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 383372002175 putative trimer interface [polypeptide binding]; other site 383372002176 putative CoA binding site [chemical binding]; other site 383372002177 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 383372002178 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 383372002179 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 383372002180 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 383372002181 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 383372002182 EamA-like transporter family; Region: EamA; cl01037 383372002183 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 383372002184 GAF domain; Region: GAF; cl15785 383372002185 GAF domain; Region: GAF_2; pfam13185 383372002186 GAF domain; Region: GAF; cl15785 383372002187 GAF domain; Region: GAF_2; pfam13185 383372002188 GAF domain; Region: GAF; cl15785 383372002189 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 383372002190 metal binding site [ion binding]; metal-binding site 383372002191 active site 383372002192 I-site; other site 383372002193 multidrug resistance protein MdtH; Provisional; Region: PRK11646 383372002194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 383372002195 putative substrate translocation pore; other site 383372002196 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 383372002197 hypothetical protein; Provisional; Region: PRK06815 383372002198 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 383372002199 tetramer interface [polypeptide binding]; other site 383372002200 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372002201 catalytic residue [active] 383372002202 DNA polymerase III subunit beta; Validated; Region: PRK05643 383372002203 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 383372002204 putative DNA binding surface [nucleotide binding]; other site 383372002205 dimer interface [polypeptide binding]; other site 383372002206 beta-clamp/clamp loader binding surface; other site 383372002207 beta-clamp/translesion DNA polymerase binding surface; other site 383372002208 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 383372002209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372002210 TPR repeat; Region: TPR_11; pfam13414 383372002211 binding surface 383372002212 TPR motif; other site 383372002213 Predicted membrane protein [Function unknown]; Region: COG3463 383372002214 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 383372002215 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 383372002216 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 383372002217 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372002218 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372002219 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 383372002220 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 383372002221 Probable Catalytic site; other site 383372002222 metal-binding site 383372002223 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 383372002224 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 383372002225 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 383372002226 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 383372002227 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 383372002228 Ligand binding site; other site 383372002229 Putative Catalytic site; other site 383372002230 DXD motif; other site 383372002231 Protein of unknown function DUF86; Region: DUF86; cl01031 383372002232 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 383372002233 active site 383372002234 NTP binding site [chemical binding]; other site 383372002235 metal binding triad [ion binding]; metal-binding site 383372002236 antibiotic binding site [chemical binding]; other site 383372002237 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 383372002238 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 383372002239 active site 383372002240 dimer interface [polypeptide binding]; other site 383372002241 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 383372002242 Ligand Binding Site [chemical binding]; other site 383372002243 Molecular Tunnel; other site 383372002244 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931 383372002245 putative active site [active] 383372002246 putative catalytic site [active] 383372002247 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 383372002248 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 383372002249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372002250 S-adenosylmethionine binding site [chemical binding]; other site 383372002251 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 383372002252 Protein of unknown function (DUF2872); Region: DUF2872; cl11924 383372002253 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 383372002254 MatE; Region: MatE; cl10513 383372002255 pseudaminic acid synthase; Region: PseI; TIGR03586 383372002256 NeuB family; Region: NeuB; cl00496 383372002257 SAF domain; Region: SAF; cl00555 383372002258 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 383372002259 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 383372002260 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 383372002261 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 383372002262 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 383372002263 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 383372002264 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 383372002265 inhibitor-cofactor binding pocket; inhibition site 383372002266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372002267 catalytic residue [active] 383372002268 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 383372002269 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 383372002270 NAD(P) binding site [chemical binding]; other site 383372002271 homodimer interface [polypeptide binding]; other site 383372002272 substrate binding site [chemical binding]; other site 383372002273 active site 383372002274 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372002275 putative active site [active] 383372002276 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 383372002277 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 383372002278 inhibitor-cofactor binding pocket; inhibition site 383372002279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372002280 catalytic residue [active] 383372002281 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 383372002282 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 383372002283 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 383372002284 putative trimer interface [polypeptide binding]; other site 383372002285 putative active site [active] 383372002286 putative substrate binding site [chemical binding]; other site 383372002287 putative CoA binding site [chemical binding]; other site 383372002288 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 383372002289 active site 383372002290 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 383372002291 homodimer interface [polypeptide binding]; other site 383372002292 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 383372002293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372002294 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 383372002295 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 383372002296 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 383372002297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372002298 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 383372002299 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 383372002300 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 383372002301 Probable Catalytic site; other site 383372002302 metal-binding site 383372002303 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 383372002304 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 383372002305 Probable Catalytic site; other site 383372002306 metal-binding site 383372002307 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 383372002308 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 383372002309 active site 383372002310 dimer interface [polypeptide binding]; other site 383372002311 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 383372002312 Ligand Binding Site [chemical binding]; other site 383372002313 Molecular Tunnel; other site 383372002314 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372002315 putative active site [active] 383372002316 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372002317 putative active site [active] 383372002318 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372002319 putative active site [active] 383372002320 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 383372002321 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 383372002322 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 383372002323 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 383372002324 Ligand binding site; other site 383372002325 Putative Catalytic site; other site 383372002326 DXD motif; other site 383372002327 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 383372002328 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 383372002329 Heme NO binding; Region: HNOB; cl15268 383372002330 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 383372002331 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14358 383372002332 Response regulator receiver domain; Region: Response_reg; pfam00072 383372002333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372002334 active site 383372002335 phosphorylation site [posttranslational modification] 383372002336 intermolecular recognition site; other site 383372002337 dimerization interface [polypeptide binding]; other site 383372002338 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 383372002339 metal binding site [ion binding]; metal-binding site 383372002340 active site 383372002341 I-site; other site 383372002342 GAF domain; Region: GAF; cl15785 383372002343 GAF domain; Region: GAF_2; pfam13185 383372002344 GAF domain; Region: GAF; cl15785 383372002345 GAF domain; Region: GAF_2; pfam13185 383372002346 GAF domain; Region: GAF; cl15785 383372002347 GAF domain; Region: GAF_2; pfam13185 383372002348 GAF domain; Region: GAF; cl15785 383372002349 GAF domain; Region: GAF; cl15785 383372002350 GAF domain; Region: GAF_2; pfam13185 383372002351 GAF domain; Region: GAF_2; pfam13185 383372002352 GAF domain; Region: GAF; cl15785 383372002353 GAF domain; Region: GAF_2; pfam13185 383372002354 GAF domain; Region: GAF; cl15785 383372002355 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 383372002356 GAF domain; Region: GAF; cl15785 383372002357 GAF domain; Region: GAF_2; pfam13185 383372002358 GAF domain; Region: GAF; cl15785 383372002359 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 383372002360 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 383372002361 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372002362 dimer interface [polypeptide binding]; other site 383372002363 phosphorylation site [posttranslational modification] 383372002364 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372002365 ATP binding site [chemical binding]; other site 383372002366 Mg2+ binding site [ion binding]; other site 383372002367 G-X-G motif; other site 383372002368 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 383372002369 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 383372002370 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 383372002371 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 383372002372 putative NAD(P) binding site [chemical binding]; other site 383372002373 catalytic Zn binding site [ion binding]; other site 383372002374 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372002375 S-adenosylmethionine binding site [chemical binding]; other site 383372002376 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 383372002377 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 383372002378 4Fe-4S binding domain; Region: Fer4; cl02805 383372002379 Cysteine-rich domain; Region: CCG; pfam02754 383372002380 Cysteine-rich domain; Region: CCG; pfam02754 383372002381 Cysteine-rich domain; Region: CCG; pfam02754 383372002382 Cysteine-rich domain; Region: CCG; pfam02754 383372002383 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 383372002384 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 383372002385 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 383372002386 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 383372002387 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 383372002388 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372002389 putative active site [active] 383372002390 YwiC-like protein; Region: YwiC; pfam14256 383372002391 Cupin domain; Region: Cupin_2; cl09118 383372002392 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372002393 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372002394 Iron permease FTR1 family; Region: FTR1; cl00475 383372002395 Imelysin; Region: Peptidase_M75; cl09159 383372002396 kynureninase; Region: kynureninase; TIGR01814 383372002397 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 383372002398 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 383372002399 catalytic residue [active] 383372002400 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 383372002401 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 383372002402 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 383372002403 catalytic residue [active] 383372002404 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 383372002405 Cysteine-rich domain; Region: CCG; pfam02754 383372002406 Cysteine-rich domain; Region: CCG; pfam02754 383372002407 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 383372002408 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 383372002409 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 383372002410 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 383372002411 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 383372002412 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 383372002413 putative active site [active] 383372002414 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 383372002415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 383372002416 Major Facilitator Superfamily; Region: MFS_1; pfam07690 383372002417 putative substrate translocation pore; other site 383372002418 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 383372002419 GAF domain; Region: GAF_2; pfam13185 383372002420 GAF domain; Region: GAF; cl15785 383372002421 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 383372002422 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372002423 dimer interface [polypeptide binding]; other site 383372002424 phosphorylation site [posttranslational modification] 383372002425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372002426 ATP binding site [chemical binding]; other site 383372002427 Mg2+ binding site [ion binding]; other site 383372002428 G-X-G motif; other site 383372002429 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 383372002430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372002431 active site 383372002432 phosphorylation site [posttranslational modification] 383372002433 intermolecular recognition site; other site 383372002434 dimerization interface [polypeptide binding]; other site 383372002435 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 383372002436 DNA binding site [nucleotide binding] 383372002437 Predicted membrane protein (DUF2085); Region: DUF2085; cl01570 383372002438 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 383372002439 catalytic residues [active] 383372002440 Predicted membrane protein (DUF2085); Region: DUF2085; cl01570 383372002441 Rrf2 family protein; Region: rrf2_super; TIGR00738 383372002442 Helix-turn-helix domains; Region: HTH; cl00088 383372002443 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 383372002444 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 383372002445 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372002446 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 383372002447 nucleotide binding site/active site [active] 383372002448 HIT family signature motif; other site 383372002449 catalytic residue [active] 383372002450 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 383372002451 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 383372002452 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 383372002453 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 383372002454 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 383372002455 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 383372002456 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 383372002457 catalytic loop [active] 383372002458 iron binding site [ion binding]; other site 383372002459 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 383372002460 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 383372002461 putative hydrophobic ligand binding site [chemical binding]; other site 383372002462 Response regulator receiver domain; Region: Response_reg; pfam00072 383372002463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372002464 active site 383372002465 phosphorylation site [posttranslational modification] 383372002466 intermolecular recognition site; other site 383372002467 dimerization interface [polypeptide binding]; other site 383372002468 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 383372002469 GAF domain; Region: GAF; cl15785 383372002470 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 383372002471 Zn2+ binding site [ion binding]; other site 383372002472 Mg2+ binding site [ion binding]; other site 383372002473 Response regulator receiver domain; Region: Response_reg; pfam00072 383372002474 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372002475 active site 383372002476 phosphorylation site [posttranslational modification] 383372002477 intermolecular recognition site; other site 383372002478 dimerization interface [polypeptide binding]; other site 383372002479 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 383372002480 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 383372002481 active site 383372002482 nucleophile elbow; other site 383372002483 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 383372002484 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 383372002485 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 383372002486 motif II; other site 383372002487 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 383372002488 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372002489 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 383372002490 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 383372002491 Walker A/P-loop; other site 383372002492 ATP binding site [chemical binding]; other site 383372002493 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 383372002494 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 383372002495 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 383372002496 ABC transporter signature motif; other site 383372002497 Walker B; other site 383372002498 D-loop; other site 383372002499 H-loop/switch region; other site 383372002500 phosphodiesterase; Provisional; Region: PRK12704 383372002501 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 383372002502 Zn2+ binding site [ion binding]; other site 383372002503 Mg2+ binding site [ion binding]; other site 383372002504 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 383372002505 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 383372002506 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372002507 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 383372002508 Ubiquitin-like proteins; Region: UBQ; cl00155 383372002509 Protein of unknown function DUF82; Region: DUF82; pfam01927 383372002510 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 383372002511 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 383372002512 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 383372002513 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 383372002514 catalytic residues [active] 383372002515 cytidylate kinase; Provisional; Region: cmk; PRK00023 383372002516 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 383372002517 CMP-binding site; other site 383372002518 The sites determining sugar specificity; other site 383372002519 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 383372002520 B3/4 domain; Region: B3_4; cl11458 383372002521 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 383372002522 active site 383372002523 tyrosine phenol-lyase; Provisional; Region: PRK13237 383372002524 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 383372002525 substrate binding site [chemical binding]; other site 383372002526 tetramer interface [polypeptide binding]; other site 383372002527 catalytic residue [active] 383372002528 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 383372002529 Periplasmic binding domain of two-component sensor kinase signaling systems; Region: PBP1_sensor_kinase_like; cd06308 383372002530 putative ligand binding site [chemical binding]; other site 383372002531 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 383372002532 dimerization interface [polypeptide binding]; other site 383372002533 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 383372002534 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 383372002535 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 383372002536 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 383372002537 active site 383372002538 catalytic triad [active] 383372002539 dimer interface [polypeptide binding]; other site 383372002540 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 383372002541 active site 383372002542 NTP binding site [chemical binding]; other site 383372002543 metal binding triad [ion binding]; metal-binding site 383372002544 hypothetical protein; Reviewed; Region: PRK09588 383372002545 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 383372002546 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372002547 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 383372002548 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 383372002549 nucleotide binding pocket [chemical binding]; other site 383372002550 K-X-D-G motif; other site 383372002551 catalytic site [active] 383372002552 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 383372002553 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 383372002554 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 383372002555 Dimer interface [polypeptide binding]; other site 383372002556 BRCT sequence motif; other site 383372002557 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 383372002558 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; pfam13366 383372002559 Transcriptional regulator [Transcription]; Region: LysR; COG0583 383372002560 Helix-turn-helix domains; Region: HTH; cl00088 383372002561 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 383372002562 putative dimerization interface [polypeptide binding]; other site 383372002563 aconitate hydratase; Validated; Region: PRK09277 383372002564 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 383372002565 substrate binding site [chemical binding]; other site 383372002566 ligand binding site [chemical binding]; other site 383372002567 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 383372002568 substrate binding site [chemical binding]; other site 383372002569 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 383372002570 active site 383372002571 NTP binding site [chemical binding]; other site 383372002572 metal binding triad [ion binding]; metal-binding site 383372002573 antibiotic binding site [chemical binding]; other site 383372002574 Protein of unknown function DUF86; Region: DUF86; cl01031 383372002575 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372002576 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 383372002577 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 383372002578 Dimer interface [polypeptide binding]; other site 383372002579 anticodon binding site; other site 383372002580 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 383372002581 homodimer interface [polypeptide binding]; other site 383372002582 motif 1; other site 383372002583 motif 2; other site 383372002584 active site 383372002585 motif 3; other site 383372002586 PAS fold; Region: PAS_4; pfam08448 383372002587 GAF domain; Region: GAF; cl15785 383372002588 GAF domain; Region: GAF_2; pfam13185 383372002589 GAF domain; Region: GAF; cl15785 383372002590 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372002591 dimer interface [polypeptide binding]; other site 383372002592 phosphorylation site [posttranslational modification] 383372002593 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372002594 ATP binding site [chemical binding]; other site 383372002595 G-X-G motif; other site 383372002596 Response regulator receiver domain; Region: Response_reg; pfam00072 383372002597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372002598 active site 383372002599 phosphorylation site [posttranslational modification] 383372002600 intermolecular recognition site; other site 383372002601 dimerization interface [polypeptide binding]; other site 383372002602 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 383372002603 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 383372002604 AMP-binding enzyme; Region: AMP-binding; cl15778 383372002605 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 383372002606 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 383372002607 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 383372002608 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 383372002609 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 383372002610 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 383372002611 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 383372002612 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 383372002613 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 383372002614 Sulfate transporter family; Region: Sulfate_transp; cl15842 383372002615 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 383372002616 Sulfate transporter family; Region: Sulfate_transp; cl15842 383372002617 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 383372002618 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 383372002619 active site residue [active] 383372002620 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 383372002621 phage shock protein A; Region: phageshock_pspA; TIGR02977 383372002622 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 383372002623 putative homodimer interface [polypeptide binding]; other site 383372002624 putative active site pocket [active] 383372002625 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 383372002626 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 383372002627 Cysteine-rich domain; Region: CCG; pfam02754 383372002628 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 383372002629 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 383372002630 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 383372002631 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 383372002632 Fibronectin type III-like domain; Region: Fn3-like; cl15273 383372002633 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 383372002634 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 383372002635 Walker A/P-loop; other site 383372002636 ATP binding site [chemical binding]; other site 383372002637 Q-loop/lid; other site 383372002638 ABC transporter signature motif; other site 383372002639 Walker B; other site 383372002640 D-loop; other site 383372002641 H-loop/switch region; other site 383372002642 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 383372002643 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 383372002644 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 383372002645 Walker A/P-loop; other site 383372002646 ATP binding site [chemical binding]; other site 383372002647 Q-loop/lid; other site 383372002648 ABC transporter signature motif; other site 383372002649 Walker B; other site 383372002650 D-loop; other site 383372002651 H-loop/switch region; other site 383372002652 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 383372002653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372002654 dimer interface [polypeptide binding]; other site 383372002655 conserved gate region; other site 383372002656 putative PBP binding loops; other site 383372002657 ABC-ATPase subunit interface; other site 383372002658 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 383372002659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 383372002660 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 383372002661 substrate binding site [chemical binding]; other site 383372002662 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 383372002663 Transcriptional regulators [Transcription]; Region: PurR; COG1609 383372002664 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 383372002665 DNA binding site [nucleotide binding] 383372002666 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 383372002667 putative dimerization interface [polypeptide binding]; other site 383372002668 putative ligand binding site [chemical binding]; other site 383372002669 Uncharacterized conserved protein [Function unknown]; Region: COG3777 383372002670 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 383372002671 active site 2 [active] 383372002672 active site 1 [active] 383372002673 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 383372002674 CoA-transferase family III; Region: CoA_transf_3; pfam02515 383372002675 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 383372002676 CoA-transferase family III; Region: CoA_transf_3; pfam02515 383372002677 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 383372002678 CoA-transferase family III; Region: CoA_transf_3; pfam02515 383372002679 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 383372002680 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 383372002681 putative active site [active] 383372002682 putative catalytic site [active] 383372002683 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 383372002684 putative active site [active] 383372002685 putative catalytic site [active] 383372002686 enoyl-CoA hydratase; Validated; Region: PRK08139 383372002687 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 383372002688 substrate binding site [chemical binding]; other site 383372002689 oxyanion hole (OAH) forming residues; other site 383372002690 trimer interface [polypeptide binding]; other site 383372002691 dihydroorotase; Provisional; Region: PRK09237 383372002692 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 383372002693 active site 383372002694 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 383372002695 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 383372002696 NADP-binding site; other site 383372002697 homotetramer interface [polypeptide binding]; other site 383372002698 substrate binding site [chemical binding]; other site 383372002699 homodimer interface [polypeptide binding]; other site 383372002700 active site 383372002701 YceI-like domain; Region: YceI; cl01001 383372002702 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 383372002703 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 383372002704 PA14 domain; Region: PA14; cl08459 383372002705 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 383372002706 Fibronectin type III-like domain; Region: Fn3-like; cl15273 383372002707 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 383372002708 Clp amino terminal domain; Region: Clp_N; pfam02861 383372002709 Clp amino terminal domain; Region: Clp_N; pfam02861 383372002710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 383372002711 Walker A motif; other site 383372002712 ATP binding site [chemical binding]; other site 383372002713 Walker B motif; other site 383372002714 arginine finger; other site 383372002715 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 383372002716 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 383372002717 Walker A motif; other site 383372002718 ATP binding site [chemical binding]; other site 383372002719 Walker B motif; other site 383372002720 arginine finger; other site 383372002721 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 383372002722 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 383372002723 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 383372002724 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 383372002725 active site 383372002726 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 383372002727 Aspartase; Region: Aspartase; cd01357 383372002728 active sites [active] 383372002729 tetramer interface [polypeptide binding]; other site 383372002730 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 383372002731 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 383372002732 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 383372002733 Fibronectin type III-like domain; Region: Fn3-like; cl15273 383372002734 Disulfide bond isomerase protein N-terminus; Region: DsbC_N; pfam10411 383372002735 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 383372002736 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372002737 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372002738 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 383372002739 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 383372002740 Sulfatase; Region: Sulfatase; cl10460 383372002741 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 383372002742 RNA binding site [nucleotide binding]; other site 383372002743 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 383372002744 RNA binding site [nucleotide binding]; other site 383372002745 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 383372002746 RNA binding site [nucleotide binding]; other site 383372002747 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 383372002748 RNA binding site [nucleotide binding]; other site 383372002749 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372002750 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 383372002751 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 383372002752 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 383372002753 active site 383372002754 catalytic site [active] 383372002755 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372002756 putative active site [active] 383372002757 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 383372002758 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372002759 Domain of unknown function (DUF368); Region: DUF368; cl00893 383372002760 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 383372002761 DEAD-like helicases superfamily; Region: DEXDc; smart00487 383372002762 ATP binding site [chemical binding]; other site 383372002763 Mg++ binding site [ion binding]; other site 383372002764 motif III; other site 383372002765 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 383372002766 nucleotide binding region [chemical binding]; other site 383372002767 ATP-binding site [chemical binding]; other site 383372002768 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 383372002769 active site 383372002770 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 383372002771 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 383372002772 ligand binding site; other site 383372002773 oligomer interface; other site 383372002774 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 383372002775 dimer interface [polypeptide binding]; other site 383372002776 N-terminal domain interface [polypeptide binding]; other site 383372002777 sulfate 1 binding site; other site 383372002778 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 383372002779 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 383372002780 ligand binding site; other site 383372002781 oligomer interface; other site 383372002782 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 383372002783 dimer interface [polypeptide binding]; other site 383372002784 N-terminal domain interface [polypeptide binding]; other site 383372002785 sulfate 1 binding site; other site 383372002786 Bacterial PH domain; Region: DUF304; cl01348 383372002787 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 383372002788 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 383372002789 substrate binding site [chemical binding]; other site 383372002790 ATP binding site [chemical binding]; other site 383372002791 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 383372002792 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 383372002793 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 383372002794 pyruvate carboxylase subunit B; Validated; Region: PRK09282 383372002795 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 383372002796 carboxyltransferase (CT) interaction site; other site 383372002797 biotinylation site [posttranslational modification]; other site 383372002798 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 383372002799 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 383372002800 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372002801 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 383372002802 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 383372002803 dimerization interface [polypeptide binding]; other site 383372002804 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372002805 dimer interface [polypeptide binding]; other site 383372002806 phosphorylation site [posttranslational modification] 383372002807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372002808 ATP binding site [chemical binding]; other site 383372002809 Mg2+ binding site [ion binding]; other site 383372002810 G-X-G motif; other site 383372002811 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 383372002812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372002813 active site 383372002814 phosphorylation site [posttranslational modification] 383372002815 intermolecular recognition site; other site 383372002816 dimerization interface [polypeptide binding]; other site 383372002817 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 383372002818 DNA binding site [nucleotide binding] 383372002819 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 383372002820 Protein of unknown function (DUF461); Region: DUF461; cl01071 383372002821 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 383372002822 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 383372002823 motif II; other site 383372002824 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 383372002825 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 383372002826 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 383372002827 Helix-turn-helix domains; Region: HTH; cl00088 383372002828 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 383372002829 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 383372002830 Walker A/P-loop; other site 383372002831 ATP binding site [chemical binding]; other site 383372002832 Q-loop/lid; other site 383372002833 ABC transporter signature motif; other site 383372002834 Walker B; other site 383372002835 D-loop; other site 383372002836 H-loop/switch region; other site 383372002837 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 383372002838 ADP-glucose phosphorylase; Region: PLN02643 383372002839 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 383372002840 nucleotide binding site/active site [active] 383372002841 HIT family signature motif; other site 383372002842 catalytic residue [active] 383372002843 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 383372002844 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 383372002845 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 383372002846 enoyl-CoA hydratase; Provisional; Region: PRK05995 383372002847 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 383372002848 substrate binding site [chemical binding]; other site 383372002849 oxyanion hole (OAH) forming residues; other site 383372002850 trimer interface [polypeptide binding]; other site 383372002851 aminoglycoside resistance protein; Provisional; Region: PRK13746 383372002852 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 383372002853 active site 383372002854 NTP binding site [chemical binding]; other site 383372002855 metal binding triad [ion binding]; metal-binding site 383372002856 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 383372002857 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 383372002858 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 383372002859 ATP-grasp domain; Region: ATP-grasp_4; cl03087 383372002860 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 383372002861 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 383372002862 carboxyltransferase (CT) interaction site; other site 383372002863 biotinylation site [posttranslational modification]; other site 383372002864 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 383372002865 homodimer interface [polypeptide binding]; other site 383372002866 NAD binding site [chemical binding]; other site 383372002867 catalytic residues [active] 383372002868 substrate binding pocket [chemical binding]; other site 383372002869 flexible flap; other site 383372002870 hypothetical protein; Provisional; Region: PRK04262 383372002871 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 383372002872 dimer interface [polypeptide binding]; other site 383372002873 active site 383372002874 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 383372002875 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 383372002876 active site 383372002877 DUF35 OB-fold domain; Region: DUF35; pfam01796 383372002878 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 383372002879 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 383372002880 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 383372002881 DNA binding residues [nucleotide binding] 383372002882 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 383372002883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372002884 S-adenosylmethionine binding site [chemical binding]; other site 383372002885 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 383372002886 active site 383372002887 putative substrate binding region [chemical binding]; other site 383372002888 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 383372002889 substrate binding site [chemical binding]; other site 383372002890 dimer interface [polypeptide binding]; other site 383372002891 catalytic triad [active] 383372002892 Response regulator receiver domain; Region: Response_reg; pfam00072 383372002893 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372002894 active site 383372002895 phosphorylation site [posttranslational modification] 383372002896 intermolecular recognition site; other site 383372002897 dimerization interface [polypeptide binding]; other site 383372002898 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 383372002899 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 383372002900 Walker A motif; other site 383372002901 ATP binding site [chemical binding]; other site 383372002902 Walker B motif; other site 383372002903 arginine finger; other site 383372002904 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 383372002905 sensory histidine kinase AtoS; Provisional; Region: PRK11360 383372002906 GAF domain; Region: GAF; cl15785 383372002907 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 383372002908 GAF domain; Region: GAF; cl15785 383372002909 GAF domain; Region: GAF_2; pfam13185 383372002910 GAF domain; Region: GAF; cl15785 383372002911 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 383372002912 metal binding site [ion binding]; metal-binding site 383372002913 active site 383372002914 I-site; other site 383372002915 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 383372002916 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372002917 dimer interface [polypeptide binding]; other site 383372002918 phosphorylation site [posttranslational modification] 383372002919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372002920 ATP binding site [chemical binding]; other site 383372002921 Mg2+ binding site [ion binding]; other site 383372002922 G-X-G motif; other site 383372002923 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 383372002924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372002925 active site 383372002926 phosphorylation site [posttranslational modification] 383372002927 intermolecular recognition site; other site 383372002928 dimerization interface [polypeptide binding]; other site 383372002929 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 383372002930 DNA binding site [nucleotide binding] 383372002931 galactokinase; Provisional; Region: PRK05101 383372002932 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 383372002933 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 383372002934 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 383372002935 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 383372002936 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 383372002937 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 383372002938 Restriction endonuclease; Region: Mrr_cat; cl00516 383372002939 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 383372002940 L-aspartate oxidase; Provisional; Region: PRK09077 383372002941 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372002942 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 383372002943 Quinolinate synthetase A protein; Region: NadA; cl00420 383372002944 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 383372002945 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 383372002946 dimerization interface [polypeptide binding]; other site 383372002947 active site 383372002948 YcfA-like protein; Region: YcfA; cl00752 383372002949 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 383372002950 Predicted transcriptional regulator [Transcription]; Region: COG2378 383372002951 Helix-turn-helix domains; Region: HTH; cl00088 383372002952 WYL domain; Region: WYL; cl14852 383372002953 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372002954 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 383372002955 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 383372002956 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 383372002957 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 383372002958 active site 383372002959 NTP binding site [chemical binding]; other site 383372002960 metal binding triad [ion binding]; metal-binding site 383372002961 antibiotic binding site [chemical binding]; other site 383372002962 PUCC protein; Region: PUCC; pfam03209 383372002963 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 383372002964 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372002965 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 383372002966 ATP binding site [chemical binding]; other site 383372002967 putative Mg++ binding site [ion binding]; other site 383372002968 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 383372002969 nucleotide binding region [chemical binding]; other site 383372002970 ATP-binding site [chemical binding]; other site 383372002971 DEAD/H associated; Region: DEAD_assoc; pfam08494 383372002972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 383372002973 putative substrate translocation pore; other site 383372002974 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372002975 S-adenosylmethionine binding site [chemical binding]; other site 383372002976 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 383372002977 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 383372002978 Ligand binding site; other site 383372002979 Bacterial sugar transferase; Region: Bac_transf; cl00939 383372002980 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 383372002981 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 383372002982 inhibitor-cofactor binding pocket; inhibition site 383372002983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372002984 catalytic residue [active] 383372002985 diaminopimelate decarboxylase; Region: lysA; TIGR01048 383372002986 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 383372002987 active site 383372002988 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 383372002989 substrate binding site [chemical binding]; other site 383372002990 catalytic residues [active] 383372002991 dimer interface [polypeptide binding]; other site 383372002992 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 383372002993 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 383372002994 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 383372002995 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 383372002996 dimer interface [polypeptide binding]; other site 383372002997 catalytic triad [active] 383372002998 peroxidatic and resolving cysteines [active] 383372002999 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 383372003000 PAS fold; Region: PAS_4; pfam08448 383372003001 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 383372003002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 383372003003 active site 383372003004 phosphorylation site [posttranslational modification] 383372003005 dimerization interface [polypeptide binding]; other site 383372003006 Helix-turn-helix domains; Region: HTH; cl00088 383372003007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 383372003008 H+ Antiporter protein; Region: 2A0121; TIGR00900 383372003009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 383372003010 active site 383372003011 phosphorylation site [posttranslational modification] 383372003012 dimerization interface [polypeptide binding]; other site 383372003013 Helix-turn-helix domains; Region: HTH; cl00088 383372003014 DNA binding residues [nucleotide binding] 383372003015 dimerization interface [polypeptide binding]; other site 383372003016 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 383372003017 Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706 383372003018 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 383372003019 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 383372003020 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 383372003021 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 383372003022 active site 383372003023 catalytic tetrad [active] 383372003024 Cupin domain; Region: Cupin_2; cl09118 383372003025 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 383372003026 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 383372003027 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 383372003028 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 383372003029 NADP+ binding site [chemical binding]; other site 383372003030 folate binding site [chemical binding]; other site 383372003031 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 383372003032 GAF domain; Region: GAF_2; pfam13185 383372003033 GAF domain; Region: GAF; cl15785 383372003034 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 383372003035 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372003036 dimer interface [polypeptide binding]; other site 383372003037 phosphorylation site [posttranslational modification] 383372003038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372003039 ATP binding site [chemical binding]; other site 383372003040 Mg2+ binding site [ion binding]; other site 383372003041 G-X-G motif; other site 383372003042 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 383372003043 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 383372003044 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 383372003045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372003046 dimer interface [polypeptide binding]; other site 383372003047 conserved gate region; other site 383372003048 putative PBP binding loops; other site 383372003049 ABC-ATPase subunit interface; other site 383372003050 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 383372003051 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 383372003052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372003053 dimer interface [polypeptide binding]; other site 383372003054 conserved gate region; other site 383372003055 putative PBP binding loops; other site 383372003056 ABC-ATPase subunit interface; other site 383372003057 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 383372003058 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 383372003059 Walker A/P-loop; other site 383372003060 ATP binding site [chemical binding]; other site 383372003061 Q-loop/lid; other site 383372003062 ABC transporter signature motif; other site 383372003063 Walker B; other site 383372003064 D-loop; other site 383372003065 H-loop/switch region; other site 383372003066 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 383372003067 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 383372003068 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 383372003069 Walker A/P-loop; other site 383372003070 ATP binding site [chemical binding]; other site 383372003071 Q-loop/lid; other site 383372003072 ABC transporter signature motif; other site 383372003073 Walker B; other site 383372003074 D-loop; other site 383372003075 H-loop/switch region; other site 383372003076 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 383372003077 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 383372003078 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 383372003079 Walker A/P-loop; other site 383372003080 ATP binding site [chemical binding]; other site 383372003081 Q-loop/lid; other site 383372003082 ABC transporter signature motif; other site 383372003083 Walker B; other site 383372003084 D-loop; other site 383372003085 H-loop/switch region; other site 383372003086 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 383372003087 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 383372003088 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 383372003089 Walker A/P-loop; other site 383372003090 ATP binding site [chemical binding]; other site 383372003091 Q-loop/lid; other site 383372003092 ABC transporter signature motif; other site 383372003093 Walker B; other site 383372003094 D-loop; other site 383372003095 H-loop/switch region; other site 383372003096 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 383372003097 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372003098 putative active site [active] 383372003099 YdjC-like protein; Region: YdjC; cl01344 383372003100 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 383372003101 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 383372003102 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 383372003103 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 383372003104 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 383372003105 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 383372003106 putative peptidoglycan binding site; other site 383372003107 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 383372003108 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 383372003109 5S rRNA interface [nucleotide binding]; other site 383372003110 CTC domain interface [polypeptide binding]; other site 383372003111 L16 interface [polypeptide binding]; other site 383372003112 LexA repressor; Validated; Region: PRK00215 383372003113 Helix-turn-helix domains; Region: HTH; cl00088 383372003114 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 383372003115 Catalytic site [active] 383372003116 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 383372003117 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 383372003118 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 383372003119 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 383372003120 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372003121 recombination factor protein RarA; Reviewed; Region: PRK13342 383372003122 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 383372003123 Walker A motif; other site 383372003124 ATP binding site [chemical binding]; other site 383372003125 Walker B motif; other site 383372003126 arginine finger; other site 383372003127 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 383372003128 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 383372003129 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 383372003130 thymidine kinase; Provisional; Region: PRK04296 383372003131 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372003132 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372003133 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 383372003134 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 383372003135 Integral membrane protein DUF95; Region: DUF95; cl00572 383372003136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 383372003137 putative substrate translocation pore; other site 383372003138 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 383372003139 Heterokaryon incompatibility protein Het-C; Region: Het-C; pfam07217 383372003140 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 383372003141 active site 383372003142 cell division protein FtsZ; Validated; Region: PRK09330 383372003143 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 383372003144 nucleotide binding site [chemical binding]; other site 383372003145 SulA interaction site; other site 383372003146 cell division protein FtsA; Region: ftsA; TIGR01174 383372003147 Cell division protein FtsA; Region: FtsA; cl11496 383372003148 Cell division protein FtsA; Region: FtsA; cl11496 383372003149 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 383372003150 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 383372003151 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 383372003152 ATP-grasp domain; Region: ATP-grasp_4; cl03087 383372003153 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14649 383372003154 FAD binding domain; Region: FAD_binding_4; pfam01565 383372003155 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 383372003156 Tetratricopeptide repeat; Region: TPR_12; pfam13424 383372003157 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 383372003158 Tetratricopeptide repeat; Region: TPR_12; pfam13424 383372003159 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 383372003160 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 383372003161 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 383372003162 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 383372003163 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 383372003164 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 383372003165 active site 383372003166 homodimer interface [polypeptide binding]; other site 383372003167 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 383372003168 Rhomboid family; Region: Rhomboid; cl11446 383372003169 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 383372003170 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 383372003171 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 383372003172 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 383372003173 Mg++ binding site [ion binding]; other site 383372003174 putative catalytic motif [active] 383372003175 putative substrate binding site [chemical binding]; other site 383372003176 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 383372003177 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 383372003178 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 383372003179 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 383372003180 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 383372003181 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 383372003182 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 383372003183 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 383372003184 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372003185 cell division protein MraZ; Reviewed; Region: PRK00326 383372003186 MraZ protein; Region: MraZ; pfam02381 383372003187 MraZ protein; Region: MraZ; pfam02381 383372003188 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 383372003189 active site 383372003190 NTP binding site [chemical binding]; other site 383372003191 metal binding triad [ion binding]; metal-binding site 383372003192 antibiotic binding site [chemical binding]; other site 383372003193 Protein of unknown function DUF86; Region: DUF86; cl01031 383372003194 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372003195 AAA domain; Region: AAA_21; pfam13304 383372003196 Walker A/P-loop; other site 383372003197 ATP binding site [chemical binding]; other site 383372003198 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372003199 Q-loop/lid; other site 383372003200 ABC transporter signature motif; other site 383372003201 Walker B; other site 383372003202 D-loop; other site 383372003203 H-loop/switch region; other site 383372003204 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 383372003205 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 383372003206 active site 383372003207 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 383372003208 metal-binding site [ion binding] 383372003209 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 383372003210 metal-binding site [ion binding] 383372003211 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 383372003212 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 383372003213 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 383372003214 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 383372003215 nudix motif; other site 383372003216 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14604 383372003217 RuvA N terminal domain; Region: RuvA_N; pfam01330 383372003218 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 383372003219 GAF domain; Region: GAF; cl15785 383372003220 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 383372003221 PAS domain; Region: PAS_9; pfam13426 383372003222 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 383372003223 PAS fold; Region: PAS_3; pfam08447 383372003224 putative active site [active] 383372003225 heme pocket [chemical binding]; other site 383372003226 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 383372003227 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 383372003228 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372003229 dimer interface [polypeptide binding]; other site 383372003230 phosphorylation site [posttranslational modification] 383372003231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372003232 ATP binding site [chemical binding]; other site 383372003233 Mg2+ binding site [ion binding]; other site 383372003234 G-X-G motif; other site 383372003235 Response regulator receiver domain; Region: Response_reg; pfam00072 383372003236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372003237 active site 383372003238 phosphorylation site [posttranslational modification] 383372003239 intermolecular recognition site; other site 383372003240 dimerization interface [polypeptide binding]; other site 383372003241 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 383372003242 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 383372003243 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 383372003244 DXD motif; other site 383372003245 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 383372003246 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 383372003247 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 383372003248 anti sigma factor interaction site; other site 383372003249 regulatory phosphorylation site [posttranslational modification]; other site 383372003250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 383372003251 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 383372003252 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 383372003253 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 383372003254 Sensor protein DegS; Region: DegS; pfam05384 383372003255 Histidine kinase; Region: HisKA_3; pfam07730 383372003256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372003257 ATP binding site [chemical binding]; other site 383372003258 Mg2+ binding site [ion binding]; other site 383372003259 G-X-G motif; other site 383372003260 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 383372003261 Ligand binding site; other site 383372003262 Putative Catalytic site; other site 383372003263 DXD motif; other site 383372003264 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 383372003265 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 383372003266 FtsX-like permease family; Region: FtsX; cl15850 383372003267 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 383372003268 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 383372003269 active site 383372003270 Riboflavin kinase; Region: Flavokinase; cl03312 383372003271 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 383372003272 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 383372003273 RNA binding site [nucleotide binding]; other site 383372003274 active site 383372003275 DHH family; Region: DHH; pfam01368 383372003276 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 383372003277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372003278 S-adenosylmethionine binding site [chemical binding]; other site 383372003279 Ribosome-binding factor A; Region: RBFA; cl00542 383372003280 translation initiation factor IF-2; Region: IF-2; TIGR00487 383372003281 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 383372003282 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 383372003283 G1 box; other site 383372003284 putative GEF interaction site [polypeptide binding]; other site 383372003285 GTP/Mg2+ binding site [chemical binding]; other site 383372003286 Switch I region; other site 383372003287 G2 box; other site 383372003288 G3 box; other site 383372003289 Switch II region; other site 383372003290 G4 box; other site 383372003291 G5 box; other site 383372003292 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 383372003293 Translation-initiation factor 2; Region: IF-2; pfam11987 383372003294 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 383372003295 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 383372003296 putative RNA binding cleft [nucleotide binding]; other site 383372003297 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 383372003298 NusA N-terminal domain; Region: NusA_N; pfam08529 383372003299 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 383372003300 RNA binding site [nucleotide binding]; other site 383372003301 homodimer interface [polypeptide binding]; other site 383372003302 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 383372003303 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 383372003304 G-X-X-G motif; other site 383372003305 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 383372003306 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 383372003307 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372003308 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 383372003309 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 383372003310 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 383372003311 NAD(P) binding site [chemical binding]; other site 383372003312 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372003313 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 383372003314 Histidine kinase; Region: HisKA_3; pfam07730 383372003315 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372003316 ATP binding site [chemical binding]; other site 383372003317 Mg2+ binding site [ion binding]; other site 383372003318 G-X-G motif; other site 383372003319 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 383372003320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372003321 active site 383372003322 phosphorylation site [posttranslational modification] 383372003323 intermolecular recognition site; other site 383372003324 dimerization interface [polypeptide binding]; other site 383372003325 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 383372003326 DNA binding residues [nucleotide binding] 383372003327 dimerization interface [polypeptide binding]; other site 383372003328 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 383372003329 putative active site [active] 383372003330 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 383372003331 hypothetical protein; Provisional; Region: PRK01346 383372003332 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 383372003333 Sterol carrier protein domain; Region: SCP2_2; pfam13530 383372003334 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 383372003335 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 383372003336 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 383372003337 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 383372003338 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 383372003339 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 383372003340 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 383372003341 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 383372003342 Bacterial SH3 domain; Region: SH3_3; cl02551 383372003343 Bacterial SH3 domain; Region: SH3_3; cl02551 383372003344 Bacterial SH3 domain; Region: SH3_3; cl02551 383372003345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372003346 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 383372003347 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 383372003348 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 383372003349 dimer interface [polypeptide binding]; other site 383372003350 glycine-pyridoxal phosphate binding site [chemical binding]; other site 383372003351 active site 383372003352 folate binding site [chemical binding]; other site 383372003353 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372003354 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 383372003355 NAD(P) binding site [chemical binding]; other site 383372003356 active site 383372003357 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 383372003358 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372003359 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 383372003360 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 383372003361 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 383372003362 active site 383372003363 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 383372003364 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 383372003365 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 383372003366 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 383372003367 PAS domain; Region: PAS_9; pfam13426 383372003368 putative active site [active] 383372003369 heme pocket [chemical binding]; other site 383372003370 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 383372003371 metal binding site [ion binding]; metal-binding site 383372003372 active site 383372003373 I-site; other site 383372003374 Protein of unknown function DUF111; Region: DUF111; cl03398 383372003375 PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855 383372003376 putative active site [active] 383372003377 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 383372003378 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 383372003379 putative active site [active] 383372003380 homotetrameric interface [polypeptide binding]; other site 383372003381 metal binding site [ion binding]; metal-binding site 383372003382 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372003383 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372003384 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 383372003385 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372003386 dimer interface [polypeptide binding]; other site 383372003387 conserved gate region; other site 383372003388 putative PBP binding loops; other site 383372003389 ABC-ATPase subunit interface; other site 383372003390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 383372003391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372003392 ABC-ATPase subunit interface; other site 383372003393 putative PBP binding loops; other site 383372003394 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 383372003395 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 383372003396 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 383372003397 dimerization interface [polypeptide binding]; other site 383372003398 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 383372003399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372003400 ATP binding site [chemical binding]; other site 383372003401 Mg2+ binding site [ion binding]; other site 383372003402 G-X-G motif; other site 383372003403 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 383372003404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372003405 active site 383372003406 phosphorylation site [posttranslational modification] 383372003407 intermolecular recognition site; other site 383372003408 dimerization interface [polypeptide binding]; other site 383372003409 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 383372003410 DNA binding site [nucleotide binding] 383372003411 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 383372003412 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372003413 S-adenosylmethionine binding site [chemical binding]; other site 383372003414 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 383372003415 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 383372003416 FeS/SAM binding site; other site 383372003417 Domain of unknown function DUF59; Region: DUF59; cl00941 383372003418 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 383372003419 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372003420 Walker A/P-loop; other site 383372003421 ATP binding site [chemical binding]; other site 383372003422 Q-loop/lid; other site 383372003423 ABC transporter signature motif; other site 383372003424 Walker B; other site 383372003425 D-loop; other site 383372003426 H-loop/switch region; other site 383372003427 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 383372003428 Sulfate transporter family; Region: Sulfate_transp; cl15842 383372003429 high affinity sulphate transporter 1; Region: sulP; TIGR00815 383372003430 Sulfate transporter family; Region: Sulfate_transp; cl15842 383372003431 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 383372003432 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 383372003433 active site 383372003434 catalytic residues [active] 383372003435 DsrE/DsrF-like family; Region: DrsE; cl00672 383372003436 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 383372003437 CPxP motif; other site 383372003438 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 383372003439 active site residue [active] 383372003440 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 383372003441 Cytochrome c; Region: Cytochrom_C; cl11414 383372003442 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 383372003443 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 383372003444 RNA/DNA hybrid binding site [nucleotide binding]; other site 383372003445 active site 383372003446 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 383372003447 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372003448 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 383372003449 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 383372003450 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372003451 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 383372003452 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 383372003453 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 383372003454 anti sigma factor interaction site; other site 383372003455 regulatory phosphorylation site [posttranslational modification]; other site 383372003456 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 383372003457 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 383372003458 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 383372003459 anti sigma factor interaction site; other site 383372003460 regulatory phosphorylation site [posttranslational modification]; other site 383372003461 GAF domain; Region: GAF_2; pfam13185 383372003462 GAF domain; Region: GAF; cl15785 383372003463 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 383372003464 GAF domain; Region: GAF; cl15785 383372003465 GAF domain; Region: GAF_2; pfam13185 383372003466 GAF domain; Region: GAF; cl15785 383372003467 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 383372003468 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 383372003469 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 383372003470 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 383372003471 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 383372003472 nucleophile elbow; other site 383372003473 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 383372003474 Clp protease ATP binding subunit; Region: clpC; CHL00095 383372003475 Clp amino terminal domain; Region: Clp_N; pfam02861 383372003476 Clp amino terminal domain; Region: Clp_N; pfam02861 383372003477 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 383372003478 Walker A motif; other site 383372003479 ATP binding site [chemical binding]; other site 383372003480 Walker B motif; other site 383372003481 arginine finger; other site 383372003482 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 383372003483 Walker A motif; other site 383372003484 ATP binding site [chemical binding]; other site 383372003485 Walker B motif; other site 383372003486 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 383372003487 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 383372003488 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 383372003489 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 383372003490 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 383372003491 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 383372003492 Ferrochelatase; Region: Ferrochelatase; pfam00762 383372003493 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 383372003494 active site 383372003495 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 383372003496 active site 383372003497 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 383372003498 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 383372003499 glutaminase active site [active] 383372003500 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 383372003501 dimer interface [polypeptide binding]; other site 383372003502 active site 383372003503 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 383372003504 dimer interface [polypeptide binding]; other site 383372003505 active site 383372003506 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 383372003507 active site 383372003508 NTP binding site [chemical binding]; other site 383372003509 metal binding triad [ion binding]; metal-binding site 383372003510 antibiotic binding site [chemical binding]; other site 383372003511 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl08495 383372003512 hypothetical protein; Provisional; Region: PRK08912 383372003513 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 383372003514 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372003515 homodimer interface [polypeptide binding]; other site 383372003516 catalytic residue [active] 383372003517 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 383372003518 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 383372003519 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 383372003520 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 383372003521 ring oligomerisation interface [polypeptide binding]; other site 383372003522 ATP/Mg binding site [chemical binding]; other site 383372003523 stacking interactions; other site 383372003524 hinge regions; other site 383372003525 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 383372003526 oligomerisation interface [polypeptide binding]; other site 383372003527 mobile loop; other site 383372003528 roof hairpin; other site 383372003529 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 383372003530 putative active site [active] 383372003531 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 383372003532 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 383372003533 substrate binding site; other site 383372003534 metal-binding site 383372003535 Oligomer interface; other site 383372003536 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 383372003537 putative carboxyl-terminal-processing protease, deltaproteobacterial; Region: prc_long_Delta; TIGR03900 383372003538 Bacterial SH3 domain; Region: SH3_3; cl02551 383372003539 Bacterial SH3 domain; Region: SH3_3; cl02551 383372003540 Bacterial SH3 domain; Region: SH3_3; cl02551 383372003541 NlpC/P60 family; Region: NLPC_P60; cl11438 383372003542 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 383372003543 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 383372003544 active site 383372003545 catalytic site [active] 383372003546 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 383372003547 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 383372003548 active site 383372003549 substrate binding site [chemical binding]; other site 383372003550 metal binding site [ion binding]; metal-binding site 383372003551 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 383372003552 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 383372003553 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 383372003554 synthetase active site [active] 383372003555 NTP binding site [chemical binding]; other site 383372003556 metal binding site [ion binding]; metal-binding site 383372003557 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 383372003558 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 383372003559 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 383372003560 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 383372003561 putative active site [active] 383372003562 Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; Region: ALDH_AldH-CAJ73105; cd07131 383372003563 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 383372003564 NAD binding site [chemical binding]; other site 383372003565 catalytic residues [active] 383372003566 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372003567 S-adenosylmethionine binding site [chemical binding]; other site 383372003568 acetylornithine aminotransferase; Provisional; Region: PRK02627 383372003569 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 383372003570 inhibitor-cofactor binding pocket; inhibition site 383372003571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372003572 catalytic residue [active] 383372003573 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 383372003574 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 383372003575 active site 383372003576 metal binding site [ion binding]; metal-binding site 383372003577 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 383372003578 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 383372003579 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 383372003580 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 383372003581 DNA binding residues [nucleotide binding] 383372003582 dimerization interface [polypeptide binding]; other site 383372003583 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 383372003584 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 383372003585 protein binding site [polypeptide binding]; other site 383372003586 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 383372003587 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 383372003588 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 383372003589 protein binding site [polypeptide binding]; other site 383372003590 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 383372003591 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 383372003592 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 383372003593 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 383372003594 Walker A/P-loop; other site 383372003595 ATP binding site [chemical binding]; other site 383372003596 Q-loop/lid; other site 383372003597 ABC transporter signature motif; other site 383372003598 Walker B; other site 383372003599 D-loop; other site 383372003600 H-loop/switch region; other site 383372003601 TOBE domain; Region: TOBE_2; cl01440 383372003602 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 383372003603 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 383372003604 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 383372003605 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 383372003606 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 383372003607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372003608 putative PBP binding loops; other site 383372003609 ABC-ATPase subunit interface; other site 383372003610 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 383372003611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372003612 dimer interface [polypeptide binding]; other site 383372003613 conserved gate region; other site 383372003614 putative PBP binding loops; other site 383372003615 ABC-ATPase subunit interface; other site 383372003616 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 383372003617 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372003618 Walker A/P-loop; other site 383372003619 ATP binding site [chemical binding]; other site 383372003620 Q-loop/lid; other site 383372003621 ABC transporter signature motif; other site 383372003622 Walker B; other site 383372003623 D-loop; other site 383372003624 H-loop/switch region; other site 383372003625 TOBE domain; Region: TOBE_2; cl01440 383372003626 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 383372003627 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372003628 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 383372003629 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 383372003630 Right handed beta helix region; Region: Beta_helix; pfam13229 383372003631 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 383372003632 isocitrate dehydrogenase; Validated; Region: PRK06451 383372003633 FOG: CBS domain [General function prediction only]; Region: COG0517 383372003634 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 383372003635 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 383372003636 apolar tunnel; other site 383372003637 heme binding site [chemical binding]; other site 383372003638 dimerization interface [polypeptide binding]; other site 383372003639 Sulfatase; Region: Sulfatase; cl10460 383372003640 HEAT repeats; Region: HEAT_2; pfam13646 383372003641 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; pfam13366 383372003642 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 383372003643 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 383372003644 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 383372003645 active site 383372003646 catalytic site [active] 383372003647 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 383372003648 nudix motif; other site 383372003649 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 383372003650 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 383372003651 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 383372003652 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 383372003653 Walker A/P-loop; other site 383372003654 ATP binding site [chemical binding]; other site 383372003655 Q-loop/lid; other site 383372003656 ABC transporter signature motif; other site 383372003657 Walker B; other site 383372003658 D-loop; other site 383372003659 H-loop/switch region; other site 383372003660 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 383372003661 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 383372003662 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372003663 Walker A/P-loop; other site 383372003664 ATP binding site [chemical binding]; other site 383372003665 Q-loop/lid; other site 383372003666 ABC transporter signature motif; other site 383372003667 Walker B; other site 383372003668 D-loop; other site 383372003669 H-loop/switch region; other site 383372003670 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 383372003671 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 383372003672 NADP binding site [chemical binding]; other site 383372003673 homodimer interface [polypeptide binding]; other site 383372003674 active site 383372003675 KduI/IolB family; Region: KduI; cl01508 383372003676 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 383372003677 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 383372003678 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 383372003679 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 383372003680 XdhC Rossmann domain; Region: XdhC_C; pfam13478 383372003681 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 383372003682 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 383372003683 NodB motif; other site 383372003684 active site 383372003685 catalytic site [active] 383372003686 metal binding site [ion binding]; metal-binding site 383372003687 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 383372003688 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 383372003689 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372003690 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 383372003691 Protein of unknown function (DUF402); Region: DUF402; cl00979 383372003692 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372003693 rod shape-determining protein MreB; Provisional; Region: PRK13930 383372003694 Cell division protein FtsA; Region: FtsA; cl11496 383372003695 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 383372003696 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 383372003697 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 383372003698 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 383372003699 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 383372003700 alpha subunit interaction interface [polypeptide binding]; other site 383372003701 Walker A motif; other site 383372003702 ATP binding site [chemical binding]; other site 383372003703 Walker B motif; other site 383372003704 inhibitor binding site; inhibition site 383372003705 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 383372003706 ATP synthase; Region: ATP-synt; cl00365 383372003707 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 383372003708 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 383372003709 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 383372003710 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 383372003711 beta subunit interaction interface [polypeptide binding]; other site 383372003712 Walker A motif; other site 383372003713 ATP binding site [chemical binding]; other site 383372003714 Walker B motif; other site 383372003715 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 383372003716 Plant ATP synthase F0; Region: YMF19; cl07975 383372003717 Plant ATP synthase F0; Region: YMF19; cl07975 383372003718 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 383372003719 ATP synthase subunit C; Region: ATP-synt_C; cl00466 383372003720 ATP synthase A chain; Region: ATP-synt_A; cl00413 383372003721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372003722 active site 383372003723 phosphorylation site [posttranslational modification] 383372003724 intermolecular recognition site; other site 383372003725 dimerization interface [polypeptide binding]; other site 383372003726 Response regulator receiver domain; Region: Response_reg; pfam00072 383372003727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372003728 active site 383372003729 phosphorylation site [posttranslational modification] 383372003730 intermolecular recognition site; other site 383372003731 dimerization interface [polypeptide binding]; other site 383372003732 GAF domain; Region: GAF; cl15785 383372003733 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372003734 dimer interface [polypeptide binding]; other site 383372003735 phosphorylation site [posttranslational modification] 383372003736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372003737 ATP binding site [chemical binding]; other site 383372003738 Mg2+ binding site [ion binding]; other site 383372003739 G-X-G motif; other site 383372003740 PspC domain; Region: PspC; cl00864 383372003741 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 383372003742 Transcriptional regulators [Transcription]; Region: PurR; COG1609 383372003743 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 383372003744 DNA binding site [nucleotide binding] 383372003745 domain linker motif; other site 383372003746 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 383372003747 dimerization interface [polypeptide binding]; other site 383372003748 ligand binding site [chemical binding]; other site 383372003749 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 383372003750 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 383372003751 Walker A/P-loop; other site 383372003752 ATP binding site [chemical binding]; other site 383372003753 Q-loop/lid; other site 383372003754 ABC transporter signature motif; other site 383372003755 Walker B; other site 383372003756 D-loop; other site 383372003757 H-loop/switch region; other site 383372003758 TOBE domain; Region: TOBE_2; cl01440 383372003759 Domain of unknown function (DUF385); Region: DUF385; cl04387 383372003760 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 383372003761 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 383372003762 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 383372003763 Protein of unknown function (DUF520); Region: DUF520; cl00723 383372003764 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 383372003765 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 383372003766 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 383372003767 FeS/SAM binding site; other site 383372003768 Helix-turn-helix domains; Region: HTH; cl00088 383372003769 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 383372003770 substrate binding pocket [chemical binding]; other site 383372003771 chain length determination region; other site 383372003772 substrate-Mg2+ binding site; other site 383372003773 catalytic residues [active] 383372003774 aspartate-rich region 1; other site 383372003775 active site lid residues [active] 383372003776 aspartate-rich region 2; other site 383372003777 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 383372003778 Integrase core domain; Region: rve; cl01316 383372003779 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 383372003780 putative substrate translocation pore; other site 383372003781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 383372003782 GTPase Era; Reviewed; Region: era; PRK00089 383372003783 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 383372003784 G1 box; other site 383372003785 GTP/Mg2+ binding site [chemical binding]; other site 383372003786 Switch I region; other site 383372003787 G2 box; other site 383372003788 Switch II region; other site 383372003789 G3 box; other site 383372003790 G4 box; other site 383372003791 G5 box; other site 383372003792 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 383372003793 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372003794 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372003795 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 383372003796 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 383372003797 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372003798 S-adenosylmethionine binding site [chemical binding]; other site 383372003799 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372003800 Type III pantothenate kinase; Region: Pan_kinase; cl09130 383372003801 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 383372003802 active site 383372003803 homotetramer interface [polypeptide binding]; other site 383372003804 homodimer interface [polypeptide binding]; other site 383372003805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372003806 S-adenosylmethionine binding site [chemical binding]; other site 383372003807 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 383372003808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372003809 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 383372003810 Bacterial Ig-like domain; Region: Big_5; cl01012 383372003811 Bacterial Ig-like domain; Region: Big_5; cl01012 383372003812 Bacterial Ig-like domain; Region: Big_5; cl01012 383372003813 Bacterial Ig-like domain; Region: Big_5; cl01012 383372003814 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 383372003815 MG2 domain; Region: A2M_N; pfam01835 383372003816 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 383372003817 Alpha-2-macroglobulin family; Region: A2M; pfam00207 383372003818 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 383372003819 surface patch; other site 383372003820 thioester region; other site 383372003821 specificity defining residues; other site 383372003822 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 383372003823 active site 383372003824 NTP binding site [chemical binding]; other site 383372003825 metal binding triad [ion binding]; metal-binding site 383372003826 antibiotic binding site [chemical binding]; other site 383372003827 HEPN domain; Region: HEPN; cl00824 383372003828 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 383372003829 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 383372003830 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 383372003831 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 383372003832 active site 383372003833 metal binding site [ion binding]; metal-binding site 383372003834 DNA binding site [nucleotide binding] 383372003835 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 383372003836 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 383372003837 active site 383372003838 Domain of unknown function (DUF955); Region: DUF955; cl01076 383372003839 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 383372003840 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 383372003841 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 383372003842 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 383372003843 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 383372003844 Ligand Binding Site [chemical binding]; other site 383372003845 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 383372003846 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 383372003847 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 383372003848 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 383372003849 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 383372003850 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 383372003851 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 383372003852 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 383372003853 putative dimer interface [polypeptide binding]; other site 383372003854 [2Fe-2S] cluster binding site [ion binding]; other site 383372003855 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 383372003856 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 383372003857 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 383372003858 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 383372003859 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 383372003860 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 383372003861 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 383372003862 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 383372003863 DNA binding site [nucleotide binding] 383372003864 active site 383372003865 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 383372003866 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 383372003867 Probable Catalytic site; other site 383372003868 metal-binding site 383372003869 Septum formation initiator; Region: DivIC; cl11433 383372003870 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 383372003871 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 383372003872 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 383372003873 active site clefts [active] 383372003874 zinc binding site [ion binding]; other site 383372003875 dimer interface [polypeptide binding]; other site 383372003876 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 383372003877 catalytic triad [active] 383372003878 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372003879 putative active site [active] 383372003880 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372003881 putative active site [active] 383372003882 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 383372003883 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 383372003884 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372003885 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 383372003886 putative active site [active] 383372003887 putative metal binding site [ion binding]; other site 383372003888 Membrane protein of unknown function; Region: DUF360; cl00850 383372003889 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 383372003890 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 383372003891 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 383372003892 putative active site [active] 383372003893 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 383372003894 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 383372003895 putative trimer interface [polypeptide binding]; other site 383372003896 putative CoA binding site [chemical binding]; other site 383372003897 Bacterial sugar transferase; Region: Bac_transf; cl00939 383372003898 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 383372003899 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 383372003900 putative ADP-binding pocket [chemical binding]; other site 383372003901 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 383372003902 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 383372003903 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 383372003904 Probable Catalytic site; other site 383372003905 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 383372003906 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 383372003907 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 383372003908 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 383372003909 O-Antigen ligase; Region: Wzy_C; cl04850 383372003910 MatE; Region: MatE; cl10513 383372003911 Chain length determinant protein; Region: Wzz; cl15801 383372003912 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 383372003913 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 383372003914 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372003915 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 383372003916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372003917 active site 383372003918 phosphorylation site [posttranslational modification] 383372003919 intermolecular recognition site; other site 383372003920 dimerization interface [polypeptide binding]; other site 383372003921 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 383372003922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372003923 active site 383372003924 phosphorylation site [posttranslational modification] 383372003925 intermolecular recognition site; other site 383372003926 dimerization interface [polypeptide binding]; other site 383372003927 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 383372003928 DNA binding residues [nucleotide binding] 383372003929 dimerization interface [polypeptide binding]; other site 383372003930 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 383372003931 Histidine kinase; Region: HisKA_3; pfam07730 383372003932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372003933 ATP binding site [chemical binding]; other site 383372003934 Mg2+ binding site [ion binding]; other site 383372003935 G-X-G motif; other site 383372003936 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 383372003937 active site 383372003938 catalytic site [active] 383372003939 Tetratricopeptide repeat; Region: TPR_12; pfam13424 383372003940 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372003941 binding surface 383372003942 TPR motif; other site 383372003943 Tetratricopeptide repeat; Region: TPR_12; pfam13424 383372003944 Tetratricopeptide repeat; Region: TPR_12; pfam13424 383372003945 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 383372003946 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372003947 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 383372003948 NAD(P) binding site [chemical binding]; other site 383372003949 homodimer interface [polypeptide binding]; other site 383372003950 substrate binding site [chemical binding]; other site 383372003951 active site 383372003952 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 383372003953 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 383372003954 inhibitor-cofactor binding pocket; inhibition site 383372003955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372003956 catalytic residue [active] 383372003957 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 383372003958 metal ion-dependent adhesion site (MIDAS); other site 383372003959 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 383372003960 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 383372003961 metal ion-dependent adhesion site (MIDAS); other site 383372003962 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 383372003963 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 383372003964 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 383372003965 putative dimer interface [polypeptide binding]; other site 383372003966 [2Fe-2S] cluster binding site [ion binding]; other site 383372003967 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 383372003968 dimer interface [polypeptide binding]; other site 383372003969 [2Fe-2S] cluster binding site [ion binding]; other site 383372003970 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 383372003971 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 383372003972 SLBB domain; Region: SLBB; pfam10531 383372003973 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 383372003974 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 383372003975 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 383372003976 catalytic loop [active] 383372003977 iron binding site [ion binding]; other site 383372003978 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 383372003979 4Fe-4S binding domain; Region: Fer4; cl02805 383372003980 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 383372003981 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 383372003982 Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066 383372003983 nickel binding site [ion binding]; other site 383372003984 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 383372003985 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 383372003986 PAS domain S-box; Region: sensory_box; TIGR00229 383372003987 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 383372003988 putative active site [active] 383372003989 heme pocket [chemical binding]; other site 383372003990 PAS fold; Region: PAS_4; pfam08448 383372003991 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 383372003992 putative active site [active] 383372003993 heme pocket [chemical binding]; other site 383372003994 PAS domain S-box; Region: sensory_box; TIGR00229 383372003995 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 383372003996 putative active site [active] 383372003997 heme pocket [chemical binding]; other site 383372003998 PAS fold; Region: PAS_4; pfam08448 383372003999 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 383372004000 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 383372004001 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 383372004002 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 383372004003 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 383372004004 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 383372004005 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 383372004006 Dynamin family; Region: Dynamin_N; pfam00350 383372004007 G1 box; other site 383372004008 GTP/Mg2+ binding site [chemical binding]; other site 383372004009 G2 box; other site 383372004010 Switch I region; other site 383372004011 G3 box; other site 383372004012 Switch II region; other site 383372004013 G4 box; other site 383372004014 G5 box; other site 383372004015 Uncharacterized conserved protein [Function unknown]; Region: COG1912 383372004016 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 383372004017 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 383372004018 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372004019 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 383372004020 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 383372004021 Uncharacterized conserved protein [Function unknown]; Region: COG2718 383372004022 SpoVR like protein; Region: SpoVR; pfam04293 383372004023 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 383372004024 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 383372004025 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08332 383372004026 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 383372004027 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 383372004028 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 383372004029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372004030 S-adenosylmethionine binding site [chemical binding]; other site 383372004031 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 383372004032 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 383372004033 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 383372004034 NAD binding site [chemical binding]; other site 383372004035 sugar binding site [chemical binding]; other site 383372004036 divalent metal binding site [ion binding]; other site 383372004037 tetramer (dimer of dimers) interface [polypeptide binding]; other site 383372004038 dimer interface [polypeptide binding]; other site 383372004039 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 383372004040 active site 383372004041 NAD binding site [chemical binding]; other site 383372004042 metal binding site [ion binding]; metal-binding site 383372004043 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 383372004044 additional DNA contacts [nucleotide binding]; other site 383372004045 mismatch recognition site; other site 383372004046 active site 383372004047 zinc binding site [ion binding]; other site 383372004048 DNA intercalation site [nucleotide binding]; other site 383372004049 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 383372004050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 383372004051 cofactor binding site; other site 383372004052 DNA binding site [nucleotide binding] 383372004053 substrate interaction site [chemical binding]; other site 383372004054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 383372004055 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 383372004056 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 383372004057 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372004058 envelope glycoprotein C; Provisional; Region: PHA03269 383372004059 envelope glycoprotein C; Provisional; Region: PHA03269 383372004060 AAA-like domain; Region: AAA_10; pfam12846 383372004061 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 383372004062 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 383372004063 Peptidase family M23; Region: Peptidase_M23; pfam01551 383372004064 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 383372004065 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 383372004066 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372004067 Walker A motif; other site 383372004068 ATP binding site [chemical binding]; other site 383372004069 Walker B motif; other site 383372004070 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 383372004071 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372004072 Walker A motif; other site 383372004073 ATP binding site [chemical binding]; other site 383372004074 Walker B motif; other site 383372004075 SAF domain; Region: SAF; cl00555 383372004076 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 383372004077 TadE-like protein; Region: TadE; cl10688 383372004078 Fibronectin type III-like domain; Region: Fn3-like; cl15273 383372004079 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 383372004080 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 383372004081 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 383372004082 transaminase; Validated; Region: PRK07324 383372004083 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 383372004084 HEAT repeats; Region: HEAT_2; pfam13646 383372004085 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 383372004086 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372004087 Walker A motif; other site 383372004088 ATP binding site [chemical binding]; other site 383372004089 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 383372004090 metal ion-dependent adhesion site (MIDAS); other site 383372004091 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 383372004092 RNA binding site [nucleotide binding]; other site 383372004093 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 383372004094 RNA binding site [nucleotide binding]; other site 383372004095 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 383372004096 RNA binding site [nucleotide binding]; other site 383372004097 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 383372004098 Ribonuclease P; Region: Ribonuclease_P; cl00457 383372004099 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372004100 Restriction endonuclease EcoRI; Region: EcoRI; pfam02963 383372004101 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 383372004102 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 383372004103 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 383372004104 G-X-X-G motif; other site 383372004105 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 383372004106 RxxxH motif; other site 383372004107 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 383372004108 ATP binding site [chemical binding]; other site 383372004109 substrate binding site [chemical binding]; other site 383372004110 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 383372004111 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 383372004112 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 383372004113 translation initiation factor IF-3; Region: infC; TIGR00168 383372004114 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 383372004115 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 383372004116 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 383372004117 ribosomal protein L20; Region: rpl20; CHL00068 383372004118 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 383372004119 23S rRNA binding site [nucleotide binding]; other site 383372004120 L21 binding site [polypeptide binding]; other site 383372004121 L13 binding site [polypeptide binding]; other site 383372004122 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 383372004123 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 383372004124 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 383372004125 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 383372004126 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 383372004127 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 383372004128 dimer interface [polypeptide binding]; other site 383372004129 motif 1; other site 383372004130 active site 383372004131 motif 2; other site 383372004132 motif 3; other site 383372004133 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 383372004134 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 383372004135 putative tRNA-binding site [nucleotide binding]; other site 383372004136 B3/4 domain; Region: B3_4; cl11458 383372004137 tRNA synthetase B5 domain; Region: B5; cl08394 383372004138 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 383372004139 dimer interface [polypeptide binding]; other site 383372004140 motif 1; other site 383372004141 motif 3; other site 383372004142 motif 2; other site 383372004143 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 383372004144 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372004145 putative active site [active] 383372004146 Winged helix-turn helix; Region: HTH_29; pfam13551 383372004147 Helix-turn-helix domains; Region: HTH; cl00088 383372004148 CHAT domain; Region: CHAT; pfam12770 383372004149 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 383372004150 amidase catalytic site [active] 383372004151 Zn binding residues [ion binding]; other site 383372004152 substrate binding site [chemical binding]; other site 383372004153 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 383372004154 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 383372004155 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 383372004156 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 383372004157 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 383372004158 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 383372004159 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 383372004160 trimer interface [polypeptide binding]; other site 383372004161 putative metal binding site [ion binding]; other site 383372004162 Tic20-like protein; Region: Tic20; pfam09685 383372004163 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372004164 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 383372004165 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 383372004166 metal ion-dependent adhesion site (MIDAS); other site 383372004167 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 383372004168 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 383372004169 substrate binding pocket [chemical binding]; other site 383372004170 membrane-bound complex binding site; other site 383372004171 hinge residues; other site 383372004172 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 383372004173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 383372004174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372004175 dimer interface [polypeptide binding]; other site 383372004176 conserved gate region; other site 383372004177 putative PBP binding loops; other site 383372004178 ABC-ATPase subunit interface; other site 383372004179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372004180 dimer interface [polypeptide binding]; other site 383372004181 conserved gate region; other site 383372004182 putative PBP binding loops; other site 383372004183 ABC-ATPase subunit interface; other site 383372004184 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 383372004185 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 383372004186 Walker A/P-loop; other site 383372004187 ATP binding site [chemical binding]; other site 383372004188 Q-loop/lid; other site 383372004189 ABC transporter signature motif; other site 383372004190 Walker B; other site 383372004191 D-loop; other site 383372004192 H-loop/switch region; other site 383372004193 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 383372004194 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 383372004195 Arginase family; Region: Arginase; cl00306 383372004196 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 383372004197 heme-binding residues [chemical binding]; other site 383372004198 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 383372004199 molybdopterin cofactor binding site; other site 383372004200 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 383372004201 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 383372004202 Polysulphide reductase, NrfD; Region: NrfD; cl01295 383372004203 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 383372004204 Cytochrome c; Region: Cytochrom_C; cl11414 383372004205 Transposase IS200 like; Region: Y1_Tnp; cl00848 383372004206 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 383372004207 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 383372004208 active site 383372004209 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 383372004210 active site 383372004211 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 383372004212 Helix-turn-helix domains; Region: HTH; cl00088 383372004213 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 383372004214 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 383372004215 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 383372004216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 383372004217 Walker A motif; other site 383372004218 ATP binding site [chemical binding]; other site 383372004219 Walker B motif; other site 383372004220 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 383372004221 Clp protease; Region: CLP_protease; pfam00574 383372004222 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 383372004223 oligomer interface [polypeptide binding]; other site 383372004224 active site residues [active] 383372004225 trigger factor; Provisional; Region: tig; PRK01490 383372004226 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 383372004227 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 383372004228 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 383372004229 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 383372004230 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 383372004231 ATP binding site [chemical binding]; other site 383372004232 putative Mg++ binding site [ion binding]; other site 383372004233 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 383372004234 nucleotide binding region [chemical binding]; other site 383372004235 ATP-binding site [chemical binding]; other site 383372004236 TRCF domain; Region: TRCF; cl04088 383372004237 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 383372004238 Catalytic domain of Protein Kinases; Region: PKc; cd00180 383372004239 active site 383372004240 ATP binding site [chemical binding]; other site 383372004241 substrate binding site [chemical binding]; other site 383372004242 activation loop (A-loop); other site 383372004243 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 383372004244 phosphopeptide binding site; other site 383372004245 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 383372004246 DNA binding site [nucleotide binding] 383372004247 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 383372004248 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 383372004249 hinge; other site 383372004250 active site 383372004251 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 383372004252 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 383372004253 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 383372004254 catalytic triad [active] 383372004255 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 383372004256 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 383372004257 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 383372004258 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372004259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372004260 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 383372004261 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 383372004262 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 383372004263 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 383372004264 Nitrogen regulatory protein P-II; Region: P-II; cl00412 383372004265 Acyl transferase domain; Region: Acyl_transf_1; cl08282 383372004266 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 383372004267 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 383372004268 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 383372004269 dimer interface [polypeptide binding]; other site 383372004270 active site 383372004271 seryl-tRNA synthetase; Provisional; Region: PRK05431 383372004272 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 383372004273 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 383372004274 dimer interface [polypeptide binding]; other site 383372004275 active site 383372004276 motif 1; other site 383372004277 motif 2; other site 383372004278 motif 3; other site 383372004279 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 383372004280 putative active site [active] 383372004281 nucleotide binding site [chemical binding]; other site 383372004282 nudix motif; other site 383372004283 putative metal binding site [ion binding]; other site 383372004284 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 383372004285 nudix motif; other site 383372004286 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 383372004287 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 383372004288 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 383372004289 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 383372004290 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 383372004291 active site 383372004292 ATP binding site [chemical binding]; other site 383372004293 Uncharacterized conserved protein [Function unknown]; Region: COG1543 383372004294 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 383372004295 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 383372004296 active site residue [active] 383372004297 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 383372004298 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 383372004299 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372004300 dimer interface [polypeptide binding]; other site 383372004301 phosphorylation site [posttranslational modification] 383372004302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372004303 ATP binding site [chemical binding]; other site 383372004304 G-X-G motif; other site 383372004305 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 383372004306 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372004307 active site 383372004308 phosphorylation site [posttranslational modification] 383372004309 intermolecular recognition site; other site 383372004310 dimerization interface [polypeptide binding]; other site 383372004311 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 383372004312 DNA binding site [nucleotide binding] 383372004313 Response regulator receiver domain; Region: Response_reg; pfam00072 383372004314 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 383372004315 PAS domain; Region: PAS_9; pfam13426 383372004316 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 383372004317 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 383372004318 metal binding site [ion binding]; metal-binding site 383372004319 active site 383372004320 I-site; other site 383372004321 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 383372004322 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 383372004323 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 383372004324 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 383372004325 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372004326 Walker A/P-loop; other site 383372004327 ATP binding site [chemical binding]; other site 383372004328 Q-loop/lid; other site 383372004329 ABC transporter signature motif; other site 383372004330 Walker B; other site 383372004331 D-loop; other site 383372004332 H-loop/switch region; other site 383372004333 amidophosphoribosyltransferase; Region: purF; TIGR01134 383372004334 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 383372004335 active site 383372004336 tetramer interface [polypeptide binding]; other site 383372004337 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 383372004338 active site 383372004339 DNA polymerase I; Region: pola; TIGR00593 383372004340 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 383372004341 active site 383372004342 metal binding site 1 [ion binding]; metal-binding site 383372004343 putative 5' ssDNA interaction site; other site 383372004344 metal binding site 3; metal-binding site 383372004345 metal binding site 2 [ion binding]; metal-binding site 383372004346 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 383372004347 putative DNA binding site [nucleotide binding]; other site 383372004348 putative metal binding site [ion binding]; other site 383372004349 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 383372004350 active site 383372004351 catalytic site [active] 383372004352 substrate binding site [chemical binding]; other site 383372004353 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 383372004354 active site 383372004355 DNA binding site [nucleotide binding] 383372004356 catalytic site [active] 383372004357 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 383372004358 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 383372004359 Ligand binding site; other site 383372004360 Putative Catalytic site; other site 383372004361 DXD motif; other site 383372004362 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 383372004363 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 383372004364 PemK-like protein; Region: PemK; cl00995 383372004365 elongation factor P; Validated; Region: PRK00529 383372004366 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 383372004367 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 383372004368 RNA binding site [nucleotide binding]; other site 383372004369 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 383372004370 RNA binding site [nucleotide binding]; other site 383372004371 putative carbohydrate kinase; Provisional; Region: PRK10565 383372004372 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 383372004373 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 383372004374 putative substrate binding site [chemical binding]; other site 383372004375 putative ATP binding site [chemical binding]; other site 383372004376 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372004377 putative active site [active] 383372004378 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 383372004379 reverse gyrase; Reviewed; Region: PRK09401 383372004380 SCP-2 sterol transfer family; Region: SCP2; cl01225 383372004381 FOG: CBS domain [General function prediction only]; Region: COG0517 383372004382 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 383372004383 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 383372004384 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 383372004385 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 383372004386 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 383372004387 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 383372004388 dimer interface [polypeptide binding]; other site 383372004389 ssDNA binding site [nucleotide binding]; other site 383372004390 tetramer (dimer of dimers) interface [polypeptide binding]; other site 383372004391 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 383372004392 PPIC-type PPIASE domain; Region: Rotamase; cl08278 383372004393 Protein of unknown function (DUF2679); Region: DUF2679; pfam10882 383372004394 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 383372004395 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 383372004396 E3 interaction surface; other site 383372004397 lipoyl attachment site [posttranslational modification]; other site 383372004398 e3 binding domain; Region: E3_binding; pfam02817 383372004399 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 383372004400 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 383372004401 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 383372004402 TPP-binding site [chemical binding]; other site 383372004403 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 383372004404 Fatty acid desaturase; Region: FA_desaturase; pfam00487 383372004405 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 383372004406 putative di-iron ligands [ion binding]; other site 383372004407 PUCC protein; Region: PUCC; pfam03209 383372004408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372004409 S-adenosylmethionine binding site [chemical binding]; other site 383372004410 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 383372004411 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 383372004412 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 383372004413 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 383372004414 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 383372004415 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 383372004416 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372004417 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 383372004418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372004419 S-adenosylmethionine binding site [chemical binding]; other site 383372004420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372004421 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 383372004422 diiron binding motif [ion binding]; other site 383372004423 magnesium chelatase subunit H; Provisional; Region: PRK12493 383372004424 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 383372004425 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 383372004426 PUCC protein; Region: PUCC; pfam03209 383372004427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 383372004428 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 383372004429 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 383372004430 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 383372004431 active site 383372004432 substrate binding site [chemical binding]; other site 383372004433 catalytic site [active] 383372004434 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372004435 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372004436 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 383372004437 tartrate dehydrogenase; Provisional; Region: PRK08194 383372004438 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 383372004439 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 383372004440 substrate binding site [chemical binding]; other site 383372004441 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 383372004442 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 383372004443 substrate binding site [chemical binding]; other site 383372004444 ligand binding site [chemical binding]; other site 383372004445 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 383372004446 homodimer interface [polypeptide binding]; other site 383372004447 substrate-cofactor binding pocket; other site 383372004448 catalytic residue [active] 383372004449 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 383372004450 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 383372004451 active site 383372004452 catalytic residues [active] 383372004453 metal binding site [ion binding]; metal-binding site 383372004454 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 383372004455 prephenate dehydratase; Provisional; Region: PRK11898 383372004456 Prephenate dehydratase; Region: PDT; pfam00800 383372004457 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 383372004458 putative L-Phe binding site [chemical binding]; other site 383372004459 2-isopropylmalate synthase; Validated; Region: PRK00915 383372004460 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 383372004461 active site 383372004462 catalytic residues [active] 383372004463 metal binding site [ion binding]; metal-binding site 383372004464 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 383372004465 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 383372004466 ketol-acid reductoisomerase; Provisional; Region: PRK05479 383372004467 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372004468 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 383372004469 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 383372004470 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 383372004471 putative valine binding site [chemical binding]; other site 383372004472 dimer interface [polypeptide binding]; other site 383372004473 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 383372004474 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 383372004475 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 383372004476 PYR/PP interface [polypeptide binding]; other site 383372004477 dimer interface [polypeptide binding]; other site 383372004478 TPP binding site [chemical binding]; other site 383372004479 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 383372004480 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 383372004481 TPP-binding site [chemical binding]; other site 383372004482 dimer interface [polypeptide binding]; other site 383372004483 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 383372004484 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 383372004485 tetramer interface [polypeptide binding]; other site 383372004486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372004487 catalytic residue [active] 383372004488 homoserine dehydrogenase; Provisional; Region: PRK06270 383372004489 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 383372004490 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372004491 putative active site [active] 383372004492 S-adenosylmethionine synthetase; Validated; Region: PRK05250 383372004493 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 383372004494 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 383372004495 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 383372004496 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 383372004497 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 383372004498 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 383372004499 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 383372004500 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 383372004501 motif II; other site 383372004502 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 383372004503 PAS domain; Region: PAS_9; pfam13426 383372004504 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 383372004505 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 383372004506 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 383372004507 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372004508 homodimer interface [polypeptide binding]; other site 383372004509 catalytic residue [active] 383372004510 Thymidylate synthase complementing protein; Region: Thy1; cl03630 383372004511 Thymidylate synthase complementing protein; Region: Thy1; cl03630 383372004512 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 383372004513 active site 383372004514 catalytic triad [active] 383372004515 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 383372004516 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 383372004517 P loop; other site 383372004518 Nucleotide binding site [chemical binding]; other site 383372004519 DTAP/Switch II; other site 383372004520 Switch I; other site 383372004521 Domain of unknown function DUF59; Region: DUF59; cl00941 383372004522 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 383372004523 Cu(I) binding site [ion binding]; other site 383372004524 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 383372004525 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 383372004526 Low-spin heme binding site [chemical binding]; other site 383372004527 D-pathway; other site 383372004528 Putative water exit pathway; other site 383372004529 Binuclear center (active site) [active] 383372004530 K-pathway; other site 383372004531 Putative proton exit pathway; other site 383372004532 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 383372004533 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 383372004534 non-specific DNA binding site [nucleotide binding]; other site 383372004535 salt bridge; other site 383372004536 sequence-specific DNA binding site [nucleotide binding]; other site 383372004537 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 383372004538 peptide binding site [polypeptide binding]; other site 383372004539 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 383372004540 dimer interface [polypeptide binding]; other site 383372004541 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 383372004542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372004543 active site 383372004544 phosphorylation site [posttranslational modification] 383372004545 intermolecular recognition site; other site 383372004546 dimerization interface [polypeptide binding]; other site 383372004547 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 383372004548 DNA binding residues [nucleotide binding] 383372004549 dimerization interface [polypeptide binding]; other site 383372004550 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 383372004551 Histidine kinase; Region: HisKA_3; pfam07730 383372004552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372004553 ATP binding site [chemical binding]; other site 383372004554 Mg2+ binding site [ion binding]; other site 383372004555 G-X-G motif; other site 383372004556 Heme NO binding; Region: HNOB; cl15268 383372004557 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 383372004558 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 383372004559 FeS/SAM binding site; other site 383372004560 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 383372004561 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 383372004562 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 383372004563 FeS/SAM binding site; other site 383372004564 phytoene desaturase; Region: crtI_fam; TIGR02734 383372004565 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372004566 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 383372004567 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 383372004568 putative active site [active] 383372004569 L-lactate permease; Region: Lactate_perm; cl00701 383372004570 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 383372004571 ABC-ATPase subunit interface; other site 383372004572 dimer interface [polypeptide binding]; other site 383372004573 putative PBP binding regions; other site 383372004574 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 383372004575 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 383372004576 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 383372004577 intersubunit interface [polypeptide binding]; other site 383372004578 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 383372004579 Protein kinase domain; Region: Pkinase; pfam00069 383372004580 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 383372004581 active site 383372004582 ATP binding site [chemical binding]; other site 383372004583 substrate binding site [chemical binding]; other site 383372004584 Bacterial SH3 domain; Region: SH3_3; cl02551 383372004585 NAD-dependent deacetylase; Provisional; Region: PRK00481 383372004586 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 383372004587 NAD+ binding site [chemical binding]; other site 383372004588 substrate binding site [chemical binding]; other site 383372004589 Zn binding site [ion binding]; other site 383372004590 NAD-dependent deacetylase; Provisional; Region: PRK00481 383372004591 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 383372004592 NAD+ binding site [chemical binding]; other site 383372004593 substrate binding site [chemical binding]; other site 383372004594 Zn binding site [ion binding]; other site 383372004595 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 383372004596 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 383372004597 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 383372004598 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 383372004599 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 383372004600 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 383372004601 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 383372004602 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 383372004603 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 383372004604 G-loop; other site 383372004605 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 383372004606 DNA binding site [nucleotide binding] 383372004607 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 383372004608 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 383372004609 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 383372004610 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 383372004611 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 383372004612 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 383372004613 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 383372004614 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 383372004615 RPB10 interaction site [polypeptide binding]; other site 383372004616 RPB1 interaction site [polypeptide binding]; other site 383372004617 RPB11 interaction site [polypeptide binding]; other site 383372004618 RPB3 interaction site [polypeptide binding]; other site 383372004619 RPB12 interaction site [polypeptide binding]; other site 383372004620 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 383372004621 Protein of unknown function (DUF499); Region: DUF499; pfam04465 383372004622 Divergent AAA domain; Region: AAA_4; pfam04326 383372004623 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 383372004624 hypothetical protein; Provisional; Region: PRK07483 383372004625 AAA domain; Region: AAA_23; pfam13476 383372004626 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372004627 Walker A/P-loop; other site 383372004628 ATP binding site [chemical binding]; other site 383372004629 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 383372004630 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372004631 ABC transporter signature motif; other site 383372004632 Walker B; other site 383372004633 D-loop; other site 383372004634 H-loop/switch region; other site 383372004635 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 383372004636 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372004637 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 383372004638 putative active site [active] 383372004639 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 383372004640 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 383372004641 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 383372004642 ATP binding site [chemical binding]; other site 383372004643 putative Mg++ binding site [ion binding]; other site 383372004644 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 383372004645 nucleotide binding region [chemical binding]; other site 383372004646 ATP-binding site [chemical binding]; other site 383372004647 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 383372004648 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 383372004649 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 383372004650 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 383372004651 nudix motif; other site 383372004652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372004653 NAD(P) binding pocket [chemical binding]; other site 383372004654 GTP-binding protein LepA; Provisional; Region: PRK05433 383372004655 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 383372004656 G1 box; other site 383372004657 putative GEF interaction site [polypeptide binding]; other site 383372004658 GTP/Mg2+ binding site [chemical binding]; other site 383372004659 Switch I region; other site 383372004660 G2 box; other site 383372004661 G3 box; other site 383372004662 Switch II region; other site 383372004663 G4 box; other site 383372004664 G5 box; other site 383372004665 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 383372004666 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 383372004667 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 383372004668 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 383372004669 SurA N-terminal domain; Region: SurA_N_3; cl07813 383372004670 PPIC-type PPIASE domain; Region: Rotamase; cl08278 383372004671 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 383372004672 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 383372004673 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 383372004674 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 383372004675 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 383372004676 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 383372004677 dimer interface [polypeptide binding]; other site 383372004678 active site residues [active] 383372004679 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 383372004680 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 383372004681 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 383372004682 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 383372004683 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 383372004684 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 383372004685 AIR carboxylase; Region: AIRC; cl00310 383372004686 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 383372004687 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 383372004688 Ligand Binding Site [chemical binding]; other site 383372004689 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 383372004690 ligand binding site [chemical binding]; other site 383372004691 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 383372004692 TM-ABC transporter signature motif; other site 383372004693 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 383372004694 TM-ABC transporter signature motif; other site 383372004695 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 383372004696 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 383372004697 Walker A/P-loop; other site 383372004698 ATP binding site [chemical binding]; other site 383372004699 Q-loop/lid; other site 383372004700 ABC transporter signature motif; other site 383372004701 Walker B; other site 383372004702 D-loop; other site 383372004703 H-loop/switch region; other site 383372004704 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 383372004705 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 383372004706 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 383372004707 active site 383372004708 Protein of unknown function (DUF433); Region: DUF433; cl01030 383372004709 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 383372004710 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 383372004711 Divergent AAA domain; Region: AAA_4; pfam04326 383372004712 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 383372004713 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 383372004714 active site 383372004715 motif I; other site 383372004716 motif II; other site 383372004717 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 383372004718 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 383372004719 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 383372004720 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 383372004721 active site 383372004722 HIGH motif; other site 383372004723 nucleotide binding site [chemical binding]; other site 383372004724 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 383372004725 KMSK motif region; other site 383372004726 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 383372004727 tRNA binding surface [nucleotide binding]; other site 383372004728 anticodon binding site; other site 383372004729 Cache domain; Region: Cache_1; pfam02743 383372004730 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 383372004731 dimerization interface [polypeptide binding]; other site 383372004732 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 383372004733 GAF domain; Region: GAF; cl15785 383372004734 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372004735 dimer interface [polypeptide binding]; other site 383372004736 phosphorylation site [posttranslational modification] 383372004737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372004738 ATP binding site [chemical binding]; other site 383372004739 Mg2+ binding site [ion binding]; other site 383372004740 G-X-G motif; other site 383372004741 Response regulator receiver domain; Region: Response_reg; pfam00072 383372004742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372004743 active site 383372004744 phosphorylation site [posttranslational modification] 383372004745 intermolecular recognition site; other site 383372004746 dimerization interface [polypeptide binding]; other site 383372004747 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 383372004748 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372004749 dimer interface [polypeptide binding]; other site 383372004750 phosphorylation site [posttranslational modification] 383372004751 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372004752 ATP binding site [chemical binding]; other site 383372004753 Mg2+ binding site [ion binding]; other site 383372004754 G-X-G motif; other site 383372004755 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 383372004756 GTP-binding protein YchF; Reviewed; Region: PRK09601 383372004757 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372004758 G1 box; other site 383372004759 GTP/Mg2+ binding site [chemical binding]; other site 383372004760 G2 box; other site 383372004761 Switch I region; other site 383372004762 G3 box; other site 383372004763 Switch II region; other site 383372004764 G4 box; other site 383372004765 G5 box; other site 383372004766 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 383372004767 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 383372004768 metal binding site 2 [ion binding]; metal-binding site 383372004769 putative DNA binding helix; other site 383372004770 metal binding site 1 [ion binding]; metal-binding site 383372004771 dimer interface [polypeptide binding]; other site 383372004772 structural Zn2+ binding site [ion binding]; other site 383372004773 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 383372004774 putative active site [active] 383372004775 putative CoA binding site [chemical binding]; other site 383372004776 nudix motif; other site 383372004777 metal binding site [ion binding]; metal-binding site 383372004778 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 383372004779 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 383372004780 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 383372004781 active site 383372004782 Domain of unknown function (DUF427); Region: DUF427; cl00998 383372004783 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 383372004784 Bacterial PH domain; Region: DUF304; cl01348 383372004785 Short C-terminal domain; Region: SHOCT; cl01373 383372004786 Recombination protein O N terminal; Region: RecO_N; cl15812 383372004787 DNA repair protein RecO; Region: reco; TIGR00613 383372004788 Recombination protein O C terminal; Region: RecO_C; pfam02565 383372004789 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 383372004790 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 383372004791 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 383372004792 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 383372004793 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 383372004794 DNA binding residues [nucleotide binding] 383372004795 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 383372004796 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 383372004797 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 383372004798 active site 383372004799 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 383372004800 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 383372004801 RimM N-terminal domain; Region: RimM; pfam01782 383372004802 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 383372004803 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 383372004804 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 383372004805 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 383372004806 signal recognition particle protein; Provisional; Region: PRK10867 383372004807 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 383372004808 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 383372004809 P loop; other site 383372004810 GTP binding site [chemical binding]; other site 383372004811 Signal peptide binding domain; Region: SRP_SPB; pfam02978 383372004812 ABC-2 type transporter; Region: ABC2_membrane; cl11417 383372004813 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 383372004814 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372004815 Walker A/P-loop; other site 383372004816 ATP binding site [chemical binding]; other site 383372004817 Q-loop/lid; other site 383372004818 ABC transporter signature motif; other site 383372004819 Walker B; other site 383372004820 D-loop; other site 383372004821 H-loop/switch region; other site 383372004822 rod shape-determining protein MreB; Provisional; Region: PRK13927 383372004823 Cell division protein FtsA; Region: FtsA; cl11496 383372004824 rod shape-determining protein MreC; Region: MreC; pfam04085 383372004825 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 383372004826 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 383372004827 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 383372004828 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 383372004829 oligomeric interface; other site 383372004830 putative active site [active] 383372004831 homodimer interface [polypeptide binding]; other site 383372004832 Protein of unknown function DUF104; Region: DUF104; cl11530 383372004833 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 383372004834 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 383372004835 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 383372004836 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 383372004837 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 383372004838 ATP binding site [chemical binding]; other site 383372004839 Walker A motif; other site 383372004840 hexamer interface [polypeptide binding]; other site 383372004841 Walker B motif; other site 383372004842 Response regulator receiver domain; Region: Response_reg; pfam00072 383372004843 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372004844 active site 383372004845 phosphorylation site [posttranslational modification] 383372004846 intermolecular recognition site; other site 383372004847 dimerization interface [polypeptide binding]; other site 383372004848 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 383372004849 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 383372004850 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 383372004851 SAF domain; Region: SAF; cl00555 383372004852 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 383372004853 PA14 domain; Region: PA14; cl08459 383372004854 DNA topoisomerase I; Validated; Region: PRK06599 383372004855 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 383372004856 active site 383372004857 interdomain interaction site; other site 383372004858 putative metal-binding site [ion binding]; other site 383372004859 nucleotide binding site [chemical binding]; other site 383372004860 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 383372004861 domain I; other site 383372004862 DNA binding groove [nucleotide binding] 383372004863 phosphate binding site [ion binding]; other site 383372004864 domain II; other site 383372004865 domain III; other site 383372004866 nucleotide binding site [chemical binding]; other site 383372004867 catalytic site [active] 383372004868 domain IV; other site 383372004869 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 383372004870 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 383372004871 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 383372004872 SLBB domain; Region: SLBB; pfam10531 383372004873 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 383372004874 pyruvate kinase; Provisional; Region: PRK05826 383372004875 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 383372004876 domain interfaces; other site 383372004877 active site 383372004878 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 383372004879 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 383372004880 substrate binding pocket [chemical binding]; other site 383372004881 membrane-bound complex binding site; other site 383372004882 hinge residues; other site 383372004883 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 383372004884 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 383372004885 metal binding site [ion binding]; metal-binding site 383372004886 putative dimer interface [polypeptide binding]; other site 383372004887 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 383372004888 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 383372004889 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 383372004890 NADP binding site [chemical binding]; other site 383372004891 active site 383372004892 putative substrate binding site [chemical binding]; other site 383372004893 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 383372004894 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 383372004895 Probable Catalytic site; other site 383372004896 metal-binding site 383372004897 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 383372004898 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 383372004899 Ligand binding site; other site 383372004900 Ligand binding site; other site 383372004901 Ligand binding site; other site 383372004902 Putative Catalytic site; other site 383372004903 DXD motif; other site 383372004904 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372004905 putative active site [active] 383372004906 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372004907 putative active site [active] 383372004908 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 383372004909 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 383372004910 active site 383372004911 catalytic tetrad [active] 383372004912 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 383372004913 Transposase domain (DUF772); Region: DUF772; cl15789 383372004914 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 383372004915 Transposase domain (DUF772); Region: DUF772; cl15789 383372004916 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 383372004917 hexamer interface [polypeptide binding]; other site 383372004918 Walker B motif; other site 383372004919 Type II/IV secretion system protein; Region: T2SE; pfam00437 383372004920 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 383372004921 ATP binding site [chemical binding]; other site 383372004922 Walker A motif; other site 383372004923 hexamer interface [polypeptide binding]; other site 383372004924 Walker B motif; other site 383372004925 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 383372004926 metal ion-dependent adhesion site (MIDAS); other site 383372004927 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 383372004928 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 383372004929 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 383372004930 active site 383372004931 NTP binding site [chemical binding]; other site 383372004932 metal binding triad [ion binding]; metal-binding site 383372004933 antibiotic binding site [chemical binding]; other site 383372004934 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 383372004935 ABC-ATPase subunit interface; other site 383372004936 dimer interface [polypeptide binding]; other site 383372004937 putative PBP binding regions; other site 383372004938 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 383372004939 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 383372004940 ABC-ATPase subunit interface; other site 383372004941 dimer interface [polypeptide binding]; other site 383372004942 putative PBP binding regions; other site 383372004943 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 383372004944 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 383372004945 Metal binding protein TroA. These proteins have been shown to function as initial receptors in ABC transport of Zn2+ and possibly Fe3+ in many eubacterial species. The TroA proteins belong to the TroA superfamily of periplasmic metal binding proteins...; Region: TroA; cd01016 383372004946 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 383372004947 metal binding site [ion binding]; metal-binding site 383372004948 intersubunit interface [polypeptide binding]; other site 383372004949 Predicted membrane protein (DUF2085); Region: DUF2085; cl01570 383372004950 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 383372004951 active site 383372004952 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 383372004953 putative active site [active] 383372004954 catalytic residue [active] 383372004955 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 383372004956 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 383372004957 G1 box; other site 383372004958 GTP/Mg2+ binding site [chemical binding]; other site 383372004959 G2 box; other site 383372004960 Switch I region; other site 383372004961 G3 box; other site 383372004962 Switch II region; other site 383372004963 G4 box; other site 383372004964 G5 box; other site 383372004965 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 383372004966 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 383372004967 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 383372004968 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 383372004969 Ligand Binding Site [chemical binding]; other site 383372004970 mevalonate kinase; Region: mevalon_kin; TIGR00549 383372004971 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 383372004972 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 383372004973 FAD binding domain; Region: FAD_binding_4; pfam01565 383372004974 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 383372004975 Cysteine-rich domain; Region: CCG; pfam02754 383372004976 Cysteine-rich domain; Region: CCG; pfam02754 383372004977 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 383372004978 Sensory domain found in PocR; Region: PocR; pfam10114 383372004979 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 383372004980 GMP synthase; Reviewed; Region: guaA; PRK00074 383372004981 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 383372004982 AMP/PPi binding site [chemical binding]; other site 383372004983 candidate oxyanion hole; other site 383372004984 catalytic triad [active] 383372004985 potential glutamine specificity residues [chemical binding]; other site 383372004986 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 383372004987 ATP Binding subdomain [chemical binding]; other site 383372004988 Ligand Binding sites [chemical binding]; other site 383372004989 Dimerization subdomain; other site 383372004990 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 383372004991 catalytic core [active] 383372004992 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 383372004993 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; cl01017 383372004994 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 383372004995 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 383372004996 active site 383372004997 metal binding site [ion binding]; metal-binding site 383372004998 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 383372004999 Divergent AAA domain; Region: AAA_4; pfam04326 383372005000 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 383372005001 Helix-turn-helix domains; Region: HTH; cl00088 383372005002 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 383372005003 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_7; cd04502 383372005004 active site 383372005005 catalytic triad [active] 383372005006 oxyanion hole [active] 383372005007 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 383372005008 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 383372005009 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 383372005010 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 383372005011 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 383372005012 protein binding site [polypeptide binding]; other site 383372005013 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 383372005014 TIGR01777 family protein; Region: yfcH 383372005015 putative NAD(P) binding site [chemical binding]; other site 383372005016 putative active site [active] 383372005017 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 383372005018 active site lid residues [active] 383372005019 substrate binding pocket [chemical binding]; other site 383372005020 catalytic residues [active] 383372005021 substrate-Mg2+ binding site; other site 383372005022 aspartate-rich region 1; other site 383372005023 aspartate-rich region 2; other site 383372005024 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 383372005025 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 383372005026 DNA binding residues [nucleotide binding] 383372005027 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 383372005028 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 383372005029 B12 binding site [chemical binding]; other site 383372005030 VPS10 domain; Region: VPS10; smart00602 383372005031 Trm112p-like protein; Region: Trm112p; cl01066 383372005032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372005033 Methyltransferase domain; Region: Methyltransf_31; pfam13847 383372005034 Domain of unknown function (DUF309); Region: DUF309; cl00667 383372005035 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 383372005036 active site residue [active] 383372005037 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 383372005038 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 383372005039 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 383372005040 FeS/SAM binding site; other site 383372005041 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 383372005042 antiporter inner membrane protein; Provisional; Region: PRK11670 383372005043 Domain of unknown function DUF59; Region: DUF59; cl00941 383372005044 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 383372005045 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 383372005046 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372005047 Walker A/P-loop; other site 383372005048 ATP binding site [chemical binding]; other site 383372005049 Q-loop/lid; other site 383372005050 ABC transporter signature motif; other site 383372005051 Walker B; other site 383372005052 D-loop; other site 383372005053 H-loop/switch region; other site 383372005054 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 383372005055 Ligand Binding Site [chemical binding]; other site 383372005056 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 383372005057 Ligand Binding Site [chemical binding]; other site 383372005058 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 383372005059 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 383372005060 Walker A/P-loop; other site 383372005061 ATP binding site [chemical binding]; other site 383372005062 Q-loop/lid; other site 383372005063 ABC transporter signature motif; other site 383372005064 Walker B; other site 383372005065 D-loop; other site 383372005066 H-loop/switch region; other site 383372005067 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 383372005068 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 383372005069 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 383372005070 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 383372005071 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 383372005072 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 383372005073 ABC-2 type transporter; Region: ABC2_membrane; cl11417 383372005074 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 383372005075 Helix-turn-helix domains; Region: HTH; cl00088 383372005076 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 383372005077 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 383372005078 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 383372005079 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 383372005080 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 383372005081 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 383372005082 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 383372005083 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 383372005084 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 383372005085 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 383372005086 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 383372005087 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 383372005088 AMP-binding enzyme; Region: AMP-binding; cl15778 383372005089 AMP-binding enzyme; Region: AMP-binding; cl15778 383372005090 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 383372005091 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 383372005092 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 383372005093 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 383372005094 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 383372005095 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 383372005096 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 383372005097 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 383372005098 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 383372005099 Cation transport protein; Region: TrkH; cl10514 383372005100 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 383372005101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372005102 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 383372005103 Helix-turn-helix domains; Region: HTH; cl00088 383372005104 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 383372005105 AMP-binding enzyme; Region: AMP-binding; cl15778 383372005106 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 383372005107 CpXC protein; Region: CpXC; pfam14353 383372005108 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 383372005109 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 383372005110 active site 383372005111 metal binding site [ion binding]; metal-binding site 383372005112 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 383372005113 GAF domain; Region: GAF; cl15785 383372005114 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 383372005115 dimer interface [polypeptide binding]; other site 383372005116 phosphorylation site [posttranslational modification] 383372005117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372005118 ATP binding site [chemical binding]; other site 383372005119 Mg2+ binding site [ion binding]; other site 383372005120 G-X-G motif; other site 383372005121 Cation efflux family; Region: Cation_efflux; cl00316 383372005122 Dodecin; Region: Dodecin; cl01328 383372005123 Uncharacterized conserved protein [Function unknown]; Region: COG3760 383372005124 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 383372005125 putative deacylase active site [active] 383372005126 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 383372005127 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 383372005128 active site 383372005129 HIGH motif; other site 383372005130 dimer interface [polypeptide binding]; other site 383372005131 KMSKS motif; other site 383372005132 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 383372005133 RNA binding surface [nucleotide binding]; other site 383372005134 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 383372005135 active site 383372005136 putative substrate binding region [chemical binding]; other site 383372005137 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 383372005138 ligand binding site [chemical binding]; other site 383372005139 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 383372005140 ligand binding site [chemical binding]; other site 383372005141 flexible hinge region; other site 383372005142 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 383372005143 classical (c) SDRs; Region: SDR_c; cd05233 383372005144 NAD(P) binding site [chemical binding]; other site 383372005145 active site 383372005146 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 383372005147 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 383372005148 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 383372005149 dimerization interface [polypeptide binding]; other site 383372005150 ATP binding site [chemical binding]; other site 383372005151 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 383372005152 dimerization interface [polypeptide binding]; other site 383372005153 ATP binding site [chemical binding]; other site 383372005154 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 383372005155 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 383372005156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372005157 S-adenosylmethionine binding site [chemical binding]; other site 383372005158 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 383372005159 Putative esterase; Region: Esterase; pfam00756 383372005160 ATP-grasp domain; Region: ATP-grasp_4; cl03087 383372005161 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 383372005162 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 383372005163 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 383372005164 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 383372005165 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 383372005166 dimer interface [polypeptide binding]; other site 383372005167 active site 383372005168 CoA binding pocket [chemical binding]; other site 383372005169 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 383372005170 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 383372005171 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 383372005172 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 383372005173 active site 383372005174 (T/H)XGH motif; other site 383372005175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 383372005176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372005177 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 383372005178 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 383372005179 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 383372005180 catalytic residue [active] 383372005181 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 383372005182 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 383372005183 active site 383372005184 metal binding site [ion binding]; metal-binding site 383372005185 Sporulation and spore germination; Region: Germane; cl11253 383372005186 Sporulation and spore germination; Region: Germane; cl11253 383372005187 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 383372005188 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 383372005189 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 383372005190 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 383372005191 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 383372005192 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 383372005193 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 383372005194 Protease prsW family; Region: PrsW-protease; cl15823 383372005195 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 383372005196 N-carbamolyputrescine amidase; Region: PLN02747 383372005197 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 383372005198 putative active site; other site 383372005199 catalytic triad [active] 383372005200 putative dimer interface [polypeptide binding]; other site 383372005201 agmatine deiminase; Region: agmatine_aguA; TIGR03380 383372005202 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 383372005203 Integral membrane protein DUF92; Region: DUF92; cl00793 383372005204 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 383372005205 hydrophobic ligand binding site; other site 383372005206 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 383372005207 inhibitor binding site; inhibition site 383372005208 catalytic motif [active] 383372005209 Catalytic residue [active] 383372005210 Active site flap [active] 383372005211 MatE; Region: MatE; cl10513 383372005212 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 383372005213 MatE; Region: MatE; cl10513 383372005214 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 383372005215 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 383372005216 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 383372005217 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372005218 Walker A/P-loop; other site 383372005219 ATP binding site [chemical binding]; other site 383372005220 Q-loop/lid; other site 383372005221 ABC transporter signature motif; other site 383372005222 Walker B; other site 383372005223 D-loop; other site 383372005224 H-loop/switch region; other site 383372005225 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 383372005226 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372005227 putative active site [active] 383372005228 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 383372005229 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372005230 TPR repeat; Region: TPR_11; pfam13414 383372005231 binding surface 383372005232 TPR motif; other site 383372005233 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372005234 binding surface 383372005235 TPR motif; other site 383372005236 TPR repeat; Region: TPR_11; pfam13414 383372005237 TPR repeat; Region: TPR_11; pfam13414 383372005238 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372005239 binding surface 383372005240 TPR motif; other site 383372005241 TPR repeat; Region: TPR_11; pfam13414 383372005242 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372005243 binding surface 383372005244 TPR motif; other site 383372005245 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 383372005246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 383372005247 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 383372005248 putative substrate translocation pore; other site 383372005249 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 383372005250 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 383372005251 active site 383372005252 motif I; other site 383372005253 motif II; other site 383372005254 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 383372005255 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 383372005256 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 383372005257 putative ADP-binding pocket [chemical binding]; other site 383372005258 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 383372005259 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 383372005260 metal binding site [ion binding]; metal-binding site 383372005261 dimer interface [polypeptide binding]; other site 383372005262 PHP domain; Region: PHP; pfam02811 383372005263 Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Ade5; cd01416 383372005264 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 383372005265 ATP binding site [chemical binding]; other site 383372005266 active site 383372005267 substrate binding site [chemical binding]; other site 383372005268 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 383372005269 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 383372005270 dimerization interface [polypeptide binding]; other site 383372005271 putative ATP binding site [chemical binding]; other site 383372005272 Acylphosphatase; Region: Acylphosphatase; cl00551 383372005273 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 383372005274 HypF finger; Region: zf-HYPF; pfam07503 383372005275 HypF finger; Region: zf-HYPF; pfam07503 383372005276 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 383372005277 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 383372005278 active site 383372005279 substrate binding pocket [chemical binding]; other site 383372005280 dimer interface [polypeptide binding]; other site 383372005281 Transcriptional regulators [Transcription]; Region: PurR; COG1609 383372005282 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 383372005283 DNA binding site [nucleotide binding] 383372005284 domain linker motif; other site 383372005285 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 383372005286 putative dimerization interface [polypeptide binding]; other site 383372005287 putative ligand binding site [chemical binding]; other site 383372005288 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 383372005289 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 383372005290 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 383372005291 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 383372005292 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 383372005293 Domain of unknown function (DUF427); Region: DUF427; cl00998 383372005294 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 383372005295 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 383372005296 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 383372005297 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372005298 putative active site [active] 383372005299 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 383372005300 FtsX-like permease family; Region: FtsX; cl15850 383372005301 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 383372005302 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 383372005303 FtsX-like permease family; Region: FtsX; cl15850 383372005304 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 383372005305 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 383372005306 active site 383372005307 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 383372005308 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 383372005309 dimer interface [polypeptide binding]; other site 383372005310 putative functional site; other site 383372005311 putative MPT binding site; other site 383372005312 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 383372005313 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 383372005314 dimer interface [polypeptide binding]; other site 383372005315 putative functional site; other site 383372005316 putative MPT binding site; other site 383372005317 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 383372005318 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 383372005319 MoaE interaction surface [polypeptide binding]; other site 383372005320 MoeB interaction surface [polypeptide binding]; other site 383372005321 thiocarboxylated glycine; other site 383372005322 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 383372005323 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 383372005324 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 383372005325 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 383372005326 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372005327 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372005328 putative active site [active] 383372005329 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 383372005330 uncharacterized xylulose kinase-like proteins, subgroup 2; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 383372005331 N- and C-terminal domain interface [polypeptide binding]; other site 383372005332 active site 383372005333 catalytic site [active] 383372005334 metal binding site [ion binding]; metal-binding site 383372005335 xylulose binding site [chemical binding]; other site 383372005336 ATP binding site [chemical binding]; other site 383372005337 putative homodimer interface [polypeptide binding]; other site 383372005338 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 383372005339 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 383372005340 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 383372005341 catalytic residue [active] 383372005342 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 383372005343 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 383372005344 Catalytic domain of Protein Kinases; Region: PKc; cd00180 383372005345 active site 383372005346 ATP binding site [chemical binding]; other site 383372005347 substrate binding site [chemical binding]; other site 383372005348 activation loop (A-loop); other site 383372005349 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 383372005350 Zn binding sites [ion binding]; other site 383372005351 Putative glucoamylase; Region: Glycoamylase; pfam10091 383372005352 Putative carbohydrate binding domain; Region: CBM_X; cl05621 383372005353 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 383372005354 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 383372005355 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 383372005356 Putative carbohydrate binding domain; Region: CBM_X; cl05621 383372005357 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 383372005358 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 383372005359 Putative glucoamylase; Region: Glycoamylase; pfam10091 383372005360 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 383372005361 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 383372005362 6-phosphofructokinase, eukaryotic type; Region: 6PF1K_euk; TIGR02478 383372005363 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 383372005364 active site 383372005365 ADP/pyrophosphate binding site [chemical binding]; other site 383372005366 dimerization interface [polypeptide binding]; other site 383372005367 allosteric effector site; other site 383372005368 fructose-1,6-bisphosphate binding site; other site 383372005369 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 383372005370 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 383372005371 putative substrate-binding site; other site 383372005372 nickel binding site [ion binding]; other site 383372005373 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 383372005374 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 383372005375 active site 383372005376 metal binding site [ion binding]; metal-binding site 383372005377 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 383372005378 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 383372005379 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 383372005380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372005381 dimer interface [polypeptide binding]; other site 383372005382 conserved gate region; other site 383372005383 putative PBP binding loops; other site 383372005384 ABC-ATPase subunit interface; other site 383372005385 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 383372005386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372005387 dimer interface [polypeptide binding]; other site 383372005388 conserved gate region; other site 383372005389 putative PBP binding loops; other site 383372005390 ABC-ATPase subunit interface; other site 383372005391 Family description; Region: VCBS; pfam13517 383372005392 Family description; Region: VCBS; pfam13517 383372005393 Family description; Region: VCBS; pfam13517 383372005394 Family description; Region: VCBS; pfam13517 383372005395 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 383372005396 alpha-galactosidase; Provisional; Region: PRK15076 383372005397 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 383372005398 NAD binding site [chemical binding]; other site 383372005399 sugar binding site [chemical binding]; other site 383372005400 divalent metal binding site [ion binding]; other site 383372005401 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 383372005402 dimer interface [polypeptide binding]; other site 383372005403 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 383372005404 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 383372005405 dimer interface [polypeptide binding]; other site 383372005406 active site 383372005407 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 383372005408 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 383372005409 dimer interface [polypeptide binding]; other site 383372005410 active site 383372005411 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 383372005412 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372005413 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 383372005414 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 383372005415 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 383372005416 substrate binding site [chemical binding]; other site 383372005417 oxyanion hole (OAH) forming residues; other site 383372005418 trimer interface [polypeptide binding]; other site 383372005419 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 383372005420 active site 383372005421 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 383372005422 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 383372005423 active site 383372005424 SCP-2 sterol transfer family; Region: SCP2; cl01225 383372005425 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 383372005426 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 383372005427 dimerization interface [polypeptide binding]; other site 383372005428 ligand binding site [chemical binding]; other site 383372005429 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 383372005430 TM-ABC transporter signature motif; other site 383372005431 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 383372005432 TM-ABC transporter signature motif; other site 383372005433 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 383372005434 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 383372005435 Walker A/P-loop; other site 383372005436 ATP binding site [chemical binding]; other site 383372005437 Q-loop/lid; other site 383372005438 ABC transporter signature motif; other site 383372005439 Walker B; other site 383372005440 D-loop; other site 383372005441 H-loop/switch region; other site 383372005442 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 383372005443 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 383372005444 Walker A/P-loop; other site 383372005445 ATP binding site [chemical binding]; other site 383372005446 Q-loop/lid; other site 383372005447 ABC transporter signature motif; other site 383372005448 Walker B; other site 383372005449 D-loop; other site 383372005450 H-loop/switch region; other site 383372005451 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 383372005452 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 383372005453 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 383372005454 alanine racemase; Reviewed; Region: alr; PRK00053 383372005455 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 383372005456 active site 383372005457 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 383372005458 dimer interface [polypeptide binding]; other site 383372005459 substrate binding site [chemical binding]; other site 383372005460 catalytic residues [active] 383372005461 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 383372005462 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 383372005463 active site 383372005464 glutamine synthetase, type I; Region: GlnA; TIGR00653 383372005465 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 383372005466 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 383372005467 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 383372005468 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 383372005469 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 383372005470 active site 383372005471 dimer interface [polypeptide binding]; other site 383372005472 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 383372005473 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 383372005474 active site 383372005475 FMN binding site [chemical binding]; other site 383372005476 substrate binding site [chemical binding]; other site 383372005477 3Fe-4S cluster binding site [ion binding]; other site 383372005478 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 383372005479 domain interface; other site 383372005480 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 383372005481 Helix-turn-helix domains; Region: HTH; cl00088 383372005482 DNA binding residues [nucleotide binding] 383372005483 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 383372005484 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 383372005485 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 383372005486 DNA binding residues [nucleotide binding] 383372005487 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 383372005488 Helix-turn-helix domains; Region: HTH; cl00088 383372005489 DNA binding residues [nucleotide binding] 383372005490 HEPN domain; Region: HEPN; cl00824 383372005491 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 383372005492 active site 383372005493 NTP binding site [chemical binding]; other site 383372005494 metal binding triad [ion binding]; metal-binding site 383372005495 antibiotic binding site [chemical binding]; other site 383372005496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372005497 active site 383372005498 phosphorylation site [posttranslational modification] 383372005499 intermolecular recognition site; other site 383372005500 dimerization interface [polypeptide binding]; other site 383372005501 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 383372005502 DNA binding residues [nucleotide binding] 383372005503 dimerization interface [polypeptide binding]; other site 383372005504 Domain of unknown function DUF87; Region: DUF87; pfam01935 383372005505 AAA-like domain; Region: AAA_10; pfam12846 383372005506 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 383372005507 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 383372005508 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372005509 Trimethylamine dehydrogenase (TMADH) and histamine dehydrogenase (HD) FMN-binding domain. TMADH is an iron-sulfur flavoprotein that catalyzes the oxidative demethylation of trimethylamine to form dimethylamine and formaldehyde. The protein forms a...; Region: TMADH_HD_FMN; cd02929 383372005510 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 383372005511 FMN binding site [chemical binding]; other site 383372005512 active site 383372005513 homodimer interface [polypeptide binding]; other site 383372005514 putative catalytic residue [active] 383372005515 4Fe-4S cluster binding site [ion binding]; other site 383372005516 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372005517 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 383372005518 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372005519 TPR motif; other site 383372005520 binding surface 383372005521 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 383372005522 DNA binding residues [nucleotide binding] 383372005523 dimerization interface [polypeptide binding]; other site 383372005524 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 383372005525 active site residue [active] 383372005526 ICEA Protein; Region: ICEA; pfam05315 383372005527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372005528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372005529 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 383372005530 homotrimer interaction site [polypeptide binding]; other site 383372005531 putative active site [active] 383372005532 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 383372005533 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 383372005534 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 383372005535 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 383372005536 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 383372005537 Protein of unknown function DUF86; Region: DUF86; cl01031 383372005538 pyruvate dehydrogenase E1 component, homodimeric type; Region: aceE; TIGR00759 383372005539 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 383372005540 TPP-binding site [chemical binding]; other site 383372005541 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 383372005542 dimer interface [polypeptide binding]; other site 383372005543 PYR/PP interface [polypeptide binding]; other site 383372005544 TPP binding site [chemical binding]; other site 383372005545 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 383372005546 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 383372005547 substrate binding site [chemical binding]; other site 383372005548 active site 383372005549 catalytic residues [active] 383372005550 heterodimer interface [polypeptide binding]; other site 383372005551 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 383372005552 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 383372005553 Probable Catalytic site; other site 383372005554 metal-binding site 383372005555 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 383372005556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372005557 Bacterial sugar transferase; Region: Bac_transf; cl00939 383372005558 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 383372005559 Amidase; Region: Amidase; cl11426 383372005560 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372005561 putative active site [active] 383372005562 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372005563 putative active site [active] 383372005564 Predicted esterase [General function prediction only]; Region: COG0400 383372005565 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 383372005566 HEPN domain; Region: HEPN; cl00824 383372005567 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 383372005568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 383372005569 putative substrate translocation pore; other site 383372005570 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 383372005571 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 383372005572 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 383372005573 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372005574 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323 383372005575 gating phenylalanine in ion channel; other site 383372005576 Predicted permease [General function prediction only]; Region: COG2985 383372005577 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 383372005578 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 383372005579 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 383372005580 Response regulator receiver domain; Region: Response_reg; pfam00072 383372005581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372005582 active site 383372005583 phosphorylation site [posttranslational modification] 383372005584 intermolecular recognition site; other site 383372005585 dimerization interface [polypeptide binding]; other site 383372005586 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 383372005587 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 383372005588 Protein of unknown function (DUF422); Region: DUF422; cl00991 383372005589 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 383372005590 putative acyl-acceptor binding pocket; other site 383372005591 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 383372005592 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 383372005593 metal ion-dependent adhesion site (MIDAS); other site 383372005594 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 383372005595 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 383372005596 metal ion-dependent adhesion site (MIDAS); other site 383372005597 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 383372005598 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 383372005599 metal ion-dependent adhesion site (MIDAS); other site 383372005600 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 383372005601 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 383372005602 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 383372005603 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 383372005604 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 383372005605 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 383372005606 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 383372005607 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 383372005608 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 383372005609 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 383372005610 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 383372005611 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 383372005612 active site 383372005613 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 383372005614 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 383372005615 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 383372005616 putative active site [active] 383372005617 metal binding site [ion binding]; metal-binding site 383372005618 Predicted membrane protein [Function unknown]; Region: COG3463 383372005619 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 383372005620 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 383372005621 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 383372005622 active site 383372005623 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 383372005624 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 383372005625 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372005626 putative active site [active] 383372005627 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 383372005628 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 383372005629 active site 383372005630 homodimer interface [polypeptide binding]; other site 383372005631 catalytic site [active] 383372005632 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 383372005633 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 383372005634 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 383372005635 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 383372005636 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 383372005637 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 383372005638 Predicted transcriptional regulator [Transcription]; Region: COG2378 383372005639 Helix-turn-helix domains; Region: HTH; cl00088 383372005640 WYL domain; Region: WYL; cl14852 383372005641 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 383372005642 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 383372005643 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 383372005644 NAD(P) binding site [chemical binding]; other site 383372005645 Restriction endonuclease; Region: Mrr_cat; cl00516 383372005646 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 383372005647 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 383372005648 putative trimer interface [polypeptide binding]; other site 383372005649 putative active site [active] 383372005650 putative substrate binding site [chemical binding]; other site 383372005651 putative CoA binding site [chemical binding]; other site 383372005652 FOG: CBS domain [General function prediction only]; Region: COG0517 383372005653 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 383372005654 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372005655 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 383372005656 E3 interaction surface; other site 383372005657 lipoyl attachment site [posttranslational modification]; other site 383372005658 e3 binding domain; Region: E3_binding; pfam02817 383372005659 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 383372005660 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 383372005661 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 383372005662 alpha subunit interface [polypeptide binding]; other site 383372005663 TPP binding site [chemical binding]; other site 383372005664 heterodimer interface [polypeptide binding]; other site 383372005665 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 383372005666 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 383372005667 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 383372005668 tetramer interface [polypeptide binding]; other site 383372005669 TPP-binding site [chemical binding]; other site 383372005670 heterodimer interface [polypeptide binding]; other site 383372005671 phosphorylation loop region [posttranslational modification] 383372005672 DHH family; Region: DHH; pfam01368 383372005673 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 383372005674 RNA binding site [nucleotide binding]; other site 383372005675 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 383372005676 RNA binding site [nucleotide binding]; other site 383372005677 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 383372005678 RNA binding site [nucleotide binding]; other site 383372005679 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 383372005680 RNA binding site [nucleotide binding]; other site 383372005681 Clp protease ATP binding subunit; Region: clpC; CHL00095 383372005682 Clp amino terminal domain; Region: Clp_N; pfam02861 383372005683 Clp amino terminal domain; Region: Clp_N; pfam02861 383372005684 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 383372005685 Walker A motif; other site 383372005686 ATP binding site [chemical binding]; other site 383372005687 Walker B motif; other site 383372005688 arginine finger; other site 383372005689 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 383372005690 Walker A motif; other site 383372005691 ATP binding site [chemical binding]; other site 383372005692 Walker B motif; other site 383372005693 arginine finger; other site 383372005694 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 383372005695 DNA repair protein RadA; Provisional; Region: PRK11823 383372005696 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 383372005697 Walker A motif/ATP binding site; other site 383372005698 ATP binding site [chemical binding]; other site 383372005699 Walker B motif; other site 383372005700 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 383372005701 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 383372005702 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 383372005703 putative active site [active] 383372005704 4-aminobutyrate aminotransferase; Provisional; Region: PRK05769 383372005705 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 383372005706 inhibitor-cofactor binding pocket; inhibition site 383372005707 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372005708 catalytic residue [active] 383372005709 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 383372005710 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 383372005711 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 383372005712 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 383372005713 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 383372005714 metal binding site [ion binding]; metal-binding site 383372005715 dimer interface [polypeptide binding]; other site 383372005716 intracellular protease, PfpI family; Region: PfpI; TIGR01382 383372005717 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 383372005718 conserved cys residue [active] 383372005719 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 383372005720 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372005721 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 383372005722 DNA binding residues [nucleotide binding] 383372005723 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 383372005724 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 383372005725 tRNA; other site 383372005726 putative tRNA binding site [nucleotide binding]; other site 383372005727 putative NADP binding site [chemical binding]; other site 383372005728 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 383372005729 Chlorite dismutase; Region: Chlor_dismutase; cl01280 383372005730 methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463 383372005731 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 383372005732 substrate binding site [chemical binding]; other site 383372005733 active site 383372005734 Ferrochelatase; Region: Ferrochelatase; pfam00762 383372005735 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 383372005736 C-terminal domain interface [polypeptide binding]; other site 383372005737 active site 383372005738 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 383372005739 active site 383372005740 N-terminal domain interface [polypeptide binding]; other site 383372005741 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 383372005742 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 383372005743 domain interfaces; other site 383372005744 active site 383372005745 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 383372005746 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 383372005747 active site 383372005748 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 383372005749 dimer interface [polypeptide binding]; other site 383372005750 active site 383372005751 Schiff base residues; other site 383372005752 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 383372005753 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 383372005754 inhibitor-cofactor binding pocket; inhibition site 383372005755 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372005756 catalytic residue [active] 383372005757 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 383372005758 Leucine carboxyl methyltransferase; Region: LCM; cl01306 383372005759 Putative zinc-finger; Region: zf-HC2; cl15806 383372005760 putative anti-sigmaE protein; Provisional; Region: PRK13920 383372005761 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 383372005762 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 383372005763 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 383372005764 DNA binding residues [nucleotide binding] 383372005765 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 383372005766 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 383372005767 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 383372005768 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 383372005769 homodimer interface [polypeptide binding]; other site 383372005770 substrate-cofactor binding pocket; other site 383372005771 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372005772 catalytic residue [active] 383372005773 Probable zinc-binding domain; Region: zf-trcl; pfam13451 383372005774 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 383372005775 GAF domain; Region: GAF; cl15785 383372005776 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 383372005777 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 383372005778 Walker A motif; other site 383372005779 ATP binding site [chemical binding]; other site 383372005780 Walker B motif; other site 383372005781 arginine finger; other site 383372005782 Helix-turn-helix domains; Region: HTH; cl00088 383372005783 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 383372005784 amphipathic channel; other site 383372005785 Asn-Pro-Ala signature motifs; other site 383372005786 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 383372005787 Dak1 domain; Region: Dak1; pfam02733 383372005788 DAK2 domain; Region: Dak2; cl03685 383372005789 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372005790 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 383372005791 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 383372005792 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 383372005793 dimerization domain swap beta strand [polypeptide binding]; other site 383372005794 regulatory protein interface [polypeptide binding]; other site 383372005795 active site 383372005796 regulatory phosphorylation site [posttranslational modification]; other site 383372005797 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 383372005798 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 383372005799 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 383372005800 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 383372005801 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 383372005802 dimer interface [polypeptide binding]; other site 383372005803 ssDNA binding site [nucleotide binding]; other site 383372005804 tetramer (dimer of dimers) interface [polypeptide binding]; other site 383372005805 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 383372005806 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 383372005807 putative substrate binding pocket [chemical binding]; other site 383372005808 AC domain interface; other site 383372005809 catalytic triad [active] 383372005810 AB domain interface; other site 383372005811 interchain disulfide; other site 383372005812 prolyl-tRNA synthetase; Provisional; Region: PRK08661 383372005813 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_arch_euk; cd00778 383372005814 dimer interface [polypeptide binding]; other site 383372005815 motif 1; other site 383372005816 active site 383372005817 motif 2; other site 383372005818 motif 3; other site 383372005819 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 383372005820 anticodon binding site; other site 383372005821 zinc-binding site [ion binding]; other site 383372005822 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372005823 putative active site [active] 383372005824 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 383372005825 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 383372005826 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 383372005827 substrate binding site [chemical binding]; other site 383372005828 hexamer interface [polypeptide binding]; other site 383372005829 metal binding site [ion binding]; metal-binding site 383372005830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 383372005831 putative substrate translocation pore; other site 383372005832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 383372005833 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 383372005834 phosphopeptide binding site; other site 383372005835 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 383372005836 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 383372005837 phosphopeptide binding site; other site 383372005838 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 383372005839 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 383372005840 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 383372005841 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 383372005842 putative active site [active] 383372005843 putative FMN binding site [chemical binding]; other site 383372005844 putative substrate binding site [chemical binding]; other site 383372005845 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 383372005846 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 383372005847 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 383372005848 ligand binding site [chemical binding]; other site 383372005849 flexible hinge region; other site 383372005850 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 383372005851 active site 383372005852 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 383372005853 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 383372005854 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 383372005855 DNA binding residues [nucleotide binding] 383372005856 Phosphoglycerate kinase; Region: PGK; pfam00162 383372005857 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 383372005858 substrate binding site [chemical binding]; other site 383372005859 hinge regions; other site 383372005860 ADP binding site [chemical binding]; other site 383372005861 catalytic site [active] 383372005862 classical (c) SDRs; Region: SDR_c; cd05233 383372005863 NAD(P) binding site [chemical binding]; other site 383372005864 active site 383372005865 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 383372005866 active site 383372005867 nucleotide binding site [chemical binding]; other site 383372005868 HIGH motif; other site 383372005869 KMSKS motif; other site 383372005870 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 383372005871 Cation efflux family; Region: Cation_efflux; cl00316 383372005872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372005873 probable polyamine oxidase; Region: PLN02268 383372005874 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 383372005875 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 383372005876 NADP binding site [chemical binding]; other site 383372005877 dimer interface [polypeptide binding]; other site 383372005878 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 383372005879 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 383372005880 Probable transposase; Region: OrfB_IS605; pfam01385 383372005881 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 383372005882 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 383372005883 active site 383372005884 catalytic site [active] 383372005885 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 383372005886 Double zinc ribbon; Region: DZR; pfam12773 383372005887 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 383372005888 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 383372005889 active site residue [active] 383372005890 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 383372005891 active site residue [active] 383372005892 putative inner membrane protein; Provisional; Region: PRK11099 383372005893 Sulphur transport; Region: Sulf_transp; cl01018 383372005894 putative inner membrane protein; Provisional; Region: PRK11099 383372005895 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 383372005896 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 383372005897 active site 383372005898 catalytic triad [active] 383372005899 dimer interface [polypeptide binding]; other site 383372005900 NurA domain; Region: NurA; cl09134 383372005901 UbiA prenyltransferase family; Region: UbiA; cl00337 383372005902 homoserine dehydrogenase; Provisional; Region: PRK06270 383372005903 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372005904 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 383372005905 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 383372005906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 383372005907 Coenzyme A binding pocket [chemical binding]; other site 383372005908 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 383372005909 NADH dehydrogenase subunit B; Provisional; Region: PRK14819 383372005910 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 383372005911 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 383372005912 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 383372005913 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 383372005914 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 383372005915 4Fe-4S binding domain; Region: Fer4; cl02805 383372005916 NADH dehydrogenase; Region: NADHdh; cl00469 383372005917 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 383372005918 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 383372005919 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 383372005920 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 383372005921 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372005922 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 383372005923 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 383372005924 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 383372005925 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 383372005926 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 383372005927 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 383372005928 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 383372005929 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 383372005930 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 383372005931 CAAX protease self-immunity; Region: Abi; cl00558 383372005932 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 383372005933 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 383372005934 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 383372005935 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 383372005936 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372005937 NAD(P) binding site [chemical binding]; other site 383372005938 active site 383372005939 AAA domain; Region: AAA_32; pfam13654 383372005940 ATP-dependent protease Lon; Provisional; Region: PRK13765 383372005941 Arginase family; Region: Arginase; cl00306 383372005942 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 383372005943 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 383372005944 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 383372005945 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372005946 dimer interface [polypeptide binding]; other site 383372005947 conserved gate region; other site 383372005948 putative PBP binding loops; other site 383372005949 ABC-ATPase subunit interface; other site 383372005950 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 383372005951 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372005952 dimer interface [polypeptide binding]; other site 383372005953 conserved gate region; other site 383372005954 putative PBP binding loops; other site 383372005955 ABC-ATPase subunit interface; other site 383372005956 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 383372005957 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 383372005958 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 383372005959 Walker A/P-loop; other site 383372005960 ATP binding site [chemical binding]; other site 383372005961 Q-loop/lid; other site 383372005962 ABC transporter signature motif; other site 383372005963 Walker B; other site 383372005964 D-loop; other site 383372005965 H-loop/switch region; other site 383372005966 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 383372005967 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 383372005968 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 383372005969 ligand binding site [chemical binding]; other site 383372005970 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 383372005971 TM-ABC transporter signature motif; other site 383372005972 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 383372005973 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 383372005974 metal binding site [ion binding]; metal-binding site 383372005975 substrate binding pocket [chemical binding]; other site 383372005976 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 383372005977 classical (c) SDRs; Region: SDR_c; cd05233 383372005978 NAD(P) binding site [chemical binding]; other site 383372005979 active site 383372005980 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 383372005981 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 383372005982 Transcriptional regulators [Transcription]; Region: GntR; COG1802 383372005983 Helix-turn-helix domains; Region: HTH; cl00088 383372005984 DNA-binding site [nucleotide binding]; DNA binding site 383372005985 FCD domain; Region: FCD; cl11656 383372005986 Helix-turn-helix domains; Region: HTH; cl00088 383372005987 Bacterial transcriptional activator domain; Region: BTAD; smart01043 383372005988 Ubiquitin-like proteins; Region: UBQ; cl00155 383372005989 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 383372005990 Proteins of 100 residues with WXG; Region: WXG100; cl02005 383372005991 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 383372005992 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372005993 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 383372005994 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372005995 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372005996 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 383372005997 phosphopeptide binding site; other site 383372005998 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 383372005999 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 383372006000 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 383372006001 Catalytic domain of Protein Kinases; Region: PKc; cd00180 383372006002 active site 383372006003 ATP binding site [chemical binding]; other site 383372006004 substrate binding site [chemical binding]; other site 383372006005 activation loop (A-loop); other site 383372006006 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 383372006007 active site 383372006008 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 383372006009 Ubiquitin-like proteins; Region: UBQ; cl00155 383372006010 Proteins of 100 residues with WXG; Region: WXG100; cl02005 383372006011 NlpC/P60 family; Region: NLPC_P60; cl11438 383372006012 Proteins of 100 residues with WXG; Region: WXG100; cl02005 383372006013 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372006014 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 383372006015 C-terminal peptidase (prc); Region: prc; TIGR00225 383372006016 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 383372006017 protein binding site [polypeptide binding]; other site 383372006018 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 383372006019 Catalytic dyad [active] 383372006020 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 383372006021 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 383372006022 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372006023 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 383372006024 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 383372006025 active site 383372006026 HIGH motif; other site 383372006027 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 383372006028 KMSKS motif; other site 383372006029 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 383372006030 tRNA binding surface [nucleotide binding]; other site 383372006031 anticodon binding site; other site 383372006032 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 383372006033 serine O-acetyltransferase; Region: cysE; TIGR01172 383372006034 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 383372006035 trimer interface [polypeptide binding]; other site 383372006036 active site 383372006037 substrate binding site [chemical binding]; other site 383372006038 CoA binding site [chemical binding]; other site 383372006039 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 383372006040 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 383372006041 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 383372006042 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 383372006043 Peptidase family M23; Region: Peptidase_M23; pfam01551 383372006044 Probable galacturonosyltransferase; Region: PLN02742 383372006045 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 383372006046 Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: GCD2; COG1184 383372006047 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 383372006048 Response regulator receiver domain; Region: Response_reg; pfam00072 383372006049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372006050 active site 383372006051 phosphorylation site [posttranslational modification] 383372006052 intermolecular recognition site; other site 383372006053 dimerization interface [polypeptide binding]; other site 383372006054 GAF domain; Region: GAF; cl15785 383372006055 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 383372006056 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 383372006057 putative active site [active] 383372006058 heme pocket [chemical binding]; other site 383372006059 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372006060 dimer interface [polypeptide binding]; other site 383372006061 phosphorylation site [posttranslational modification] 383372006062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372006063 ATP binding site [chemical binding]; other site 383372006064 Mg2+ binding site [ion binding]; other site 383372006065 G-X-G motif; other site 383372006066 Response regulator receiver domain; Region: Response_reg; pfam00072 383372006067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372006068 active site 383372006069 phosphorylation site [posttranslational modification] 383372006070 intermolecular recognition site; other site 383372006071 dimerization interface [polypeptide binding]; other site 383372006072 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 383372006073 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 383372006074 protein binding site [polypeptide binding]; other site 383372006075 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 383372006076 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 383372006077 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 383372006078 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 383372006079 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 383372006080 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 383372006081 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 383372006082 glutamine binding [chemical binding]; other site 383372006083 catalytic triad [active] 383372006084 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 383372006085 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 383372006086 chorismate binding enzyme; Region: Chorismate_bind; cl10555 383372006087 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 383372006088 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 383372006089 active site 383372006090 HIGH motif; other site 383372006091 dimer interface [polypeptide binding]; other site 383372006092 KMSKS motif; other site 383372006093 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 383372006094 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 383372006095 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 383372006096 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372006097 catalytic residue [active] 383372006098 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 383372006099 phosphopeptide binding site; other site 383372006100 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 383372006101 metal ion-dependent adhesion site (MIDAS); other site 383372006102 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 383372006103 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 383372006104 active site 383372006105 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 383372006106 Catalytic domain of Protein Kinases; Region: PKc; cd00180 383372006107 active site 383372006108 ATP binding site [chemical binding]; other site 383372006109 substrate binding site [chemical binding]; other site 383372006110 activation loop (A-loop); other site 383372006111 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 383372006112 Trp docking motif [polypeptide binding]; other site 383372006113 active site 383372006114 PQQ-like domain; Region: PQQ_2; pfam13360 383372006115 Bacterial SH3 domain; Region: SH3_3; cl02551 383372006116 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 383372006117 WYL domain; Region: WYL; cl14852 383372006118 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 383372006119 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 383372006120 Walker A motif; other site 383372006121 ATP binding site [chemical binding]; other site 383372006122 Walker B motif; other site 383372006123 arginine finger; other site 383372006124 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 383372006125 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 383372006126 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 383372006127 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 383372006128 4Fe-4S binding domain; Region: Fer4; cl02805 383372006129 Polysulphide reductase, NrfD; Region: NrfD; cl01295 383372006130 This CD includes the respiratory arsenate reductase, As(V), catalytic subunit (ArrA) and other related proteins. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_Arsenate-R; cd02757 383372006131 putative [Fe4-S4] binding site [ion binding]; other site 383372006132 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 383372006133 putative molybdopterin cofactor binding site [chemical binding]; other site 383372006134 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 383372006135 putative molybdopterin cofactor binding site; other site 383372006136 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 383372006137 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 383372006138 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 383372006139 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 383372006140 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 383372006141 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 383372006142 Walker A/P-loop; other site 383372006143 ATP binding site [chemical binding]; other site 383372006144 Q-loop/lid; other site 383372006145 ABC transporter signature motif; other site 383372006146 Walker B; other site 383372006147 D-loop; other site 383372006148 H-loop/switch region; other site 383372006149 TOBE domain; Region: TOBE_2; cl01440 383372006150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372006151 dimer interface [polypeptide binding]; other site 383372006152 conserved gate region; other site 383372006153 putative PBP binding loops; other site 383372006154 ABC-ATPase subunit interface; other site 383372006155 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 383372006156 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 383372006157 Helix-turn-helix domains; Region: HTH; cl00088 383372006158 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 383372006159 Uncharacterized conserved protein [Function unknown]; Region: COG2006 383372006160 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 383372006161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372006162 dimer interface [polypeptide binding]; other site 383372006163 conserved gate region; other site 383372006164 putative PBP binding loops; other site 383372006165 ABC-ATPase subunit interface; other site 383372006166 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 383372006167 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 383372006168 Walker A/P-loop; other site 383372006169 ATP binding site [chemical binding]; other site 383372006170 Q-loop/lid; other site 383372006171 ABC transporter signature motif; other site 383372006172 Walker B; other site 383372006173 D-loop; other site 383372006174 H-loop/switch region; other site 383372006175 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372006176 ABC-ATPase subunit interface; other site 383372006177 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 383372006178 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 383372006179 substrate binding pocket [chemical binding]; other site 383372006180 membrane-bound complex binding site; other site 383372006181 hinge residues; other site 383372006182 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 383372006183 Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904 383372006184 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 383372006185 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 383372006186 metal binding site [ion binding]; metal-binding site 383372006187 putative dimer interface [polypeptide binding]; other site 383372006188 short chain dehydrogenase; Validated; Region: PRK06182 383372006189 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 383372006190 NADP binding site [chemical binding]; other site 383372006191 active site 383372006192 steroid binding site; other site 383372006193 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 383372006194 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 383372006195 PYR/PP interface [polypeptide binding]; other site 383372006196 dimer interface [polypeptide binding]; other site 383372006197 TPP binding site [chemical binding]; other site 383372006198 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 383372006199 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 383372006200 TPP-binding site; other site 383372006201 dimer interface [polypeptide binding]; other site 383372006202 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372006203 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 383372006204 L-tyrosine decarboxylase; Provisional; Region: PRK13520 383372006205 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 383372006206 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 383372006207 catalytic residue [active] 383372006208 MFS/sugar transport protein; Region: MFS_2; pfam13347 383372006209 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 383372006210 Helix-turn-helix domains; Region: HTH; cl00088 383372006211 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372006212 putative active site [active] 383372006213 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372006214 putative active site [active] 383372006215 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372006216 putative active site [active] 383372006217 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372006218 putative active site [active] 383372006219 Fibronectin type III-like domain; Region: Fn3-like; cl15273 383372006220 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 383372006221 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 383372006222 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 383372006223 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 383372006224 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 383372006225 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 383372006226 YhhN-like protein; Region: YhhN; cl01505 383372006227 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 383372006228 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 383372006229 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 383372006230 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372006231 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 383372006232 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 383372006233 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372006234 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 383372006235 NAD synthetase; Reviewed; Region: nadE; PRK02628 383372006236 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 383372006237 multimer interface [polypeptide binding]; other site 383372006238 active site 383372006239 catalytic triad [active] 383372006240 protein interface 1 [polypeptide binding]; other site 383372006241 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 383372006242 homodimer interface [polypeptide binding]; other site 383372006243 NAD binding pocket [chemical binding]; other site 383372006244 ATP binding pocket [chemical binding]; other site 383372006245 Mg binding site [ion binding]; other site 383372006246 active-site loop [active] 383372006247 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372006248 putative active site [active] 383372006249 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 383372006250 active site 383372006251 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 383372006252 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 383372006253 UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449 383372006254 putative ADP-binding pocket [chemical binding]; other site 383372006255 Fic/DOC family; Region: Fic; cl00960 383372006256 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 383372006257 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 383372006258 NADP binding site [chemical binding]; other site 383372006259 dimer interface [polypeptide binding]; other site 383372006260 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 383372006261 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 383372006262 FeS/SAM binding site; other site 383372006263 recombination protein F; Reviewed; Region: recF; PRK00064 383372006264 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 383372006265 Walker A/P-loop; other site 383372006266 ATP binding site [chemical binding]; other site 383372006267 Q-loop/lid; other site 383372006268 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372006269 ABC transporter signature motif; other site 383372006270 Walker B; other site 383372006271 D-loop; other site 383372006272 H-loop/switch region; other site 383372006273 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 383372006274 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 383372006275 homotetramer interface [polypeptide binding]; other site 383372006276 FMN binding site [chemical binding]; other site 383372006277 homodimer contacts [polypeptide binding]; other site 383372006278 putative active site [active] 383372006279 putative substrate binding site [chemical binding]; other site 383372006280 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 383372006281 active site 383372006282 MutL protein; Region: MutL; pfam13941 383372006283 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 383372006284 putative active site [active] 383372006285 dimerization interface [polypeptide binding]; other site 383372006286 putative tRNAtyr binding site [nucleotide binding]; other site 383372006287 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 383372006288 CoenzymeA binding site [chemical binding]; other site 383372006289 subunit interaction site [polypeptide binding]; other site 383372006290 PHB binding site; other site 383372006291 XamI restriction endonuclease; Region: RE_XamI; pfam09572 383372006292 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 383372006293 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 383372006294 GIY-YIG motif/motif A; other site 383372006295 putative active site [active] 383372006296 putative metal binding site [ion binding]; other site 383372006297 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 383372006298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372006299 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372006300 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 383372006301 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372006302 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 383372006303 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 383372006304 Peptidase family M23; Region: Peptidase_M23; pfam01551 383372006305 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372006306 Restriction endonuclease EcoRV; Region: Endonuc-EcoRV; pfam09233 383372006307 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 383372006308 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 383372006309 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 383372006310 Chromate transporter; Region: Chromate_transp; pfam02417 383372006311 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 383372006312 Chromate transporter; Region: Chromate_transp; pfam02417 383372006313 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 383372006314 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 383372006315 metal-binding site [ion binding] 383372006316 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 383372006317 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 383372006318 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 383372006319 Amidase; Region: Amidase; cl11426 383372006320 Protein of unknown function DUF72; Region: DUF72; cl00777 383372006321 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 383372006322 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 383372006323 putative ligand binding site [chemical binding]; other site 383372006324 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 383372006325 dimer interface [polypeptide binding]; other site 383372006326 [2Fe-2S] cluster binding site [ion binding]; other site 383372006327 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 383372006328 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 383372006329 dimer interface [polypeptide binding]; other site 383372006330 putative PBP binding regions; other site 383372006331 ABC-ATPase subunit interface; other site 383372006332 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 383372006333 Walker A/P-loop; other site 383372006334 ATP binding site [chemical binding]; other site 383372006335 ABC transporter; Region: ABC_tran; pfam00005 383372006336 Q-loop/lid; other site 383372006337 ABC transporter signature motif; other site 383372006338 Walker B; other site 383372006339 D-loop; other site 383372006340 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 383372006341 phosphopeptide binding site; other site 383372006342 GAF domain; Region: GAF; cl15785 383372006343 GAF domain; Region: GAF_2; pfam13185 383372006344 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 383372006345 cyclase homology domain; Region: CHD; cd07302 383372006346 nucleotidyl binding site; other site 383372006347 metal binding site [ion binding]; metal-binding site 383372006348 dimer interface [polypeptide binding]; other site 383372006349 PSP1 C-terminal conserved region; Region: PSP1; cl00770 383372006350 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 383372006351 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372006352 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 383372006353 Maf-like protein; Region: Maf; pfam02545 383372006354 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 383372006355 active site 383372006356 dimer interface [polypeptide binding]; other site 383372006357 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 383372006358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372006359 active site 383372006360 phosphorylation site [posttranslational modification] 383372006361 intermolecular recognition site; other site 383372006362 dimerization interface [polypeptide binding]; other site 383372006363 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 383372006364 DNA binding residues [nucleotide binding] 383372006365 dimerization interface [polypeptide binding]; other site 383372006366 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 383372006367 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 383372006368 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 383372006369 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 383372006370 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 383372006371 Domain of unknown function (DUF4212); Region: DUF4212; cl01781 383372006372 Sodium:solute symporter family; Region: SSF; cl00456 383372006373 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 383372006374 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 383372006375 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 383372006376 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 383372006377 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 383372006378 Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852 383372006379 active site 383372006380 catalytic triad [active] 383372006381 PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from...; Region: PA_subtilisin_like; cd02120 383372006382 PA/protease or protease-like domain interface [polypeptide binding]; other site 383372006383 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 383372006384 catalytic residues [active] 383372006385 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 383372006386 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 383372006387 Clostripain family; Region: Peptidase_C11; cl04055 383372006388 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 383372006389 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 383372006390 active site 383372006391 ATP binding site [chemical binding]; other site 383372006392 substrate binding site [chemical binding]; other site 383372006393 activation loop (A-loop); other site 383372006394 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 383372006395 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 383372006396 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 383372006397 putative metal binding site [ion binding]; other site 383372006398 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 383372006399 active site 383372006400 metal binding site [ion binding]; metal-binding site 383372006401 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 383372006402 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 383372006403 tetramer interface [polypeptide binding]; other site 383372006404 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372006405 catalytic residue [active] 383372006406 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 383372006407 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 383372006408 tetramer interface [polypeptide binding]; other site 383372006409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372006410 catalytic residue [active] 383372006411 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 383372006412 lipoyl attachment site [posttranslational modification]; other site 383372006413 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 383372006414 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 383372006415 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 383372006416 Response regulator receiver domain; Region: Response_reg; pfam00072 383372006417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372006418 active site 383372006419 phosphorylation site [posttranslational modification] 383372006420 intermolecular recognition site; other site 383372006421 dimerization interface [polypeptide binding]; other site 383372006422 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 383372006423 HEAT repeats; Region: HEAT_2; pfam13646 383372006424 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 383372006425 Catalytic domain of Protein Kinases; Region: PKc; cd00180 383372006426 active site 383372006427 ATP binding site [chemical binding]; other site 383372006428 substrate binding site [chemical binding]; other site 383372006429 activation loop (A-loop); other site 383372006430 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 383372006431 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 383372006432 recombination protein RecR; Reviewed; Region: recR; PRK00076 383372006433 RecR protein; Region: RecR; pfam02132 383372006434 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 383372006435 putative active site [active] 383372006436 putative metal-binding site [ion binding]; other site 383372006437 tetramer interface [polypeptide binding]; other site 383372006438 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 383372006439 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 383372006440 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 383372006441 Walker A motif; other site 383372006442 ATP binding site [chemical binding]; other site 383372006443 Walker B motif; other site 383372006444 arginine finger; other site 383372006445 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 383372006446 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372006447 putative active site [active] 383372006448 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 383372006449 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 383372006450 Protein of unknown function (DUF692); Region: DUF692; cl01263 383372006451 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 383372006452 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 383372006453 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 383372006454 Walker A/P-loop; other site 383372006455 ATP binding site [chemical binding]; other site 383372006456 Q-loop/lid; other site 383372006457 ABC transporter signature motif; other site 383372006458 Walker B; other site 383372006459 D-loop; other site 383372006460 H-loop/switch region; other site 383372006461 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 383372006462 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 383372006463 Walker A/P-loop; other site 383372006464 ATP binding site [chemical binding]; other site 383372006465 Q-loop/lid; other site 383372006466 ABC transporter signature motif; other site 383372006467 Walker B; other site 383372006468 D-loop; other site 383372006469 H-loop/switch region; other site 383372006470 Putative cyclase; Region: Cyclase; cl00814 383372006471 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 383372006472 TM-ABC transporter signature motif; other site 383372006473 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 383372006474 TM-ABC transporter signature motif; other site 383372006475 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 383372006476 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338 383372006477 putative ligand binding site [chemical binding]; other site 383372006478 Transcriptional regulators [Transcription]; Region: GntR; COG1802 383372006479 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 383372006480 DNA-binding site [nucleotide binding]; DNA binding site 383372006481 FCD domain; Region: FCD; cl11656 383372006482 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 383372006483 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 383372006484 Glutamate binding site [chemical binding]; other site 383372006485 homodimer interface [polypeptide binding]; other site 383372006486 NAD binding site [chemical binding]; other site 383372006487 catalytic residues [active] 383372006488 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 383372006489 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 383372006490 active site 383372006491 Zn binding site [ion binding]; other site 383372006492 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 383372006493 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 383372006494 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 383372006495 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 383372006496 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 383372006497 dimer interface [polypeptide binding]; other site 383372006498 PYR/PP interface [polypeptide binding]; other site 383372006499 TPP binding site [chemical binding]; other site 383372006500 substrate binding site [chemical binding]; other site 383372006501 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 383372006502 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778 383372006503 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 383372006504 TPP-binding site [chemical binding]; other site 383372006505 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 383372006506 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 383372006507 dimerization interface [polypeptide binding]; other site 383372006508 putative DNA binding site [nucleotide binding]; other site 383372006509 putative Zn2+ binding site [ion binding]; other site 383372006510 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 383372006511 Coenzyme A binding pocket [chemical binding]; other site 383372006512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372006513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 383372006514 putative substrate translocation pore; other site 383372006515 Major Facilitator Superfamily; Region: MFS_1; pfam07690 383372006516 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 383372006517 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372006518 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 383372006519 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 383372006520 dimerization interface [polypeptide binding]; other site 383372006521 putative DNA binding site [nucleotide binding]; other site 383372006522 putative Zn2+ binding site [ion binding]; other site 383372006523 Low molecular weight phosphatase family; Region: LMWPc; cd00115 383372006524 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 383372006525 active site 383372006526 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 383372006527 dimerization interface [polypeptide binding]; other site 383372006528 putative DNA binding site [nucleotide binding]; other site 383372006529 putative Zn2+ binding site [ion binding]; other site 383372006530 Low molecular weight phosphatase family; Region: LMWPc; cl00105 383372006531 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 383372006532 active site 383372006533 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 383372006534 substrate binding site [chemical binding]; other site 383372006535 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 383372006536 UV-endonuclease UvdE; Region: UvdE; cl10036 383372006537 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 383372006538 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 383372006539 HIGH motif; other site 383372006540 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 383372006541 active site 383372006542 KMSKS motif; other site 383372006543 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 383372006544 phosphopeptide binding site; other site 383372006545 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 383372006546 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 383372006547 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 383372006548 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 383372006549 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 383372006550 substrate binding pocket [chemical binding]; other site 383372006551 chain length determination region; other site 383372006552 substrate-Mg2+ binding site; other site 383372006553 catalytic residues [active] 383372006554 aspartate-rich region 1; other site 383372006555 active site lid residues [active] 383372006556 aspartate-rich region 2; other site 383372006557 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 383372006558 catalytic core [active] 383372006559 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; cl02325 383372006560 Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences; Region: Peptidase_C1A; cd02248 383372006561 active site 383372006562 S2 subsite; other site 383372006563 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 383372006564 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 383372006565 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 383372006566 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 383372006567 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 383372006568 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 383372006569 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 383372006570 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 383372006571 active site 383372006572 homodimer interface [polypeptide binding]; other site 383372006573 catalytic site [active] 383372006574 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 383372006575 Interdomain contacts; other site 383372006576 Cytokine receptor motif; other site 383372006577 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 383372006578 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 383372006579 Protein of unknown function (DUF1626); Region: DUF1626; pfam07788 383372006580 PspC domain; Region: PspC; cl00864 383372006581 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 383372006582 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 383372006583 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 383372006584 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 383372006585 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 383372006586 B12 binding site [chemical binding]; other site 383372006587 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372006588 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 383372006589 asparagine synthetase B; Provisional; Region: asnB; PRK09431 383372006590 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 383372006591 active site 383372006592 dimer interface [polypeptide binding]; other site 383372006593 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 383372006594 Ligand Binding Site [chemical binding]; other site 383372006595 Molecular Tunnel; other site 383372006596 Ferritin-like domain; Region: Ferritin; pfam00210 383372006597 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 383372006598 dimerization interface [polypeptide binding]; other site 383372006599 DPS ferroxidase diiron center [ion binding]; other site 383372006600 ion pore; other site 383372006601 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 383372006602 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 383372006603 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 383372006604 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 383372006605 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 383372006606 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 383372006607 Sterol carrier protein domain; Region: SCP2_2; pfam13530 383372006608 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372006609 S-adenosylmethionine binding site [chemical binding]; other site 383372006610 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 383372006611 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 383372006612 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 383372006613 hypothetical protein; Provisional; Region: PRK11820 383372006614 NB-ARC domain; Region: NB-ARC; pfam00931 383372006615 HEPN domain; Region: HEPN; cl00824 383372006616 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 383372006617 active site 383372006618 NTP binding site [chemical binding]; other site 383372006619 metal binding triad [ion binding]; metal-binding site 383372006620 antibiotic binding site [chemical binding]; other site 383372006621 CHAT domain; Region: CHAT; pfam12770 383372006622 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 383372006623 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 383372006624 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 383372006625 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372006626 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 383372006627 Walker A/P-loop; other site 383372006628 ATP binding site [chemical binding]; other site 383372006629 Q-loop/lid; other site 383372006630 ABC transporter signature motif; other site 383372006631 Walker B; other site 383372006632 D-loop; other site 383372006633 H-loop/switch region; other site 383372006634 GTPase RsgA; Reviewed; Region: PRK00098 383372006635 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 383372006636 RNA binding site [nucleotide binding]; other site 383372006637 homodimer interface [polypeptide binding]; other site 383372006638 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 383372006639 GTPase/Zn-binding domain interface [polypeptide binding]; other site 383372006640 GTP/Mg2+ binding site [chemical binding]; other site 383372006641 G4 box; other site 383372006642 G5 box; other site 383372006643 G1 box; other site 383372006644 Switch I region; other site 383372006645 G2 box; other site 383372006646 G3 box; other site 383372006647 Switch II region; other site 383372006648 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 383372006649 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 383372006650 ABC-2 type transporter; Region: ABC2_membrane; cl11417 383372006651 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 383372006652 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 383372006653 ABC-2 type transporter; Region: ABC2_membrane; cl11417 383372006654 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 383372006655 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 383372006656 GAF domain; Region: GAF; cl15785 383372006657 Predicted dehydrogenase [General function prediction only]; Region: COG5322 383372006658 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372006659 NAD(P) binding pocket [chemical binding]; other site 383372006660 Cytochrome c; Region: Cytochrom_C; cl11414 383372006661 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 383372006662 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 383372006663 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 383372006664 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 383372006665 P-loop; other site 383372006666 Magnesium ion binding site [ion binding]; other site 383372006667 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 383372006668 Magnesium ion binding site [ion binding]; other site 383372006669 Flavin Reductases; Region: FlaRed; cl00801 383372006670 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 383372006671 phosphopeptide binding site; other site 383372006672 EVE domain; Region: EVE; cl00728 383372006673 translocation protein TolB; Provisional; Region: tolB; PRK04792 383372006674 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 383372006675 Sulfate transporter family; Region: Sulfate_transp; cl15842 383372006676 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 383372006677 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 383372006678 dimerization interface [polypeptide binding]; other site 383372006679 putative DNA binding site [nucleotide binding]; other site 383372006680 putative Zn2+ binding site [ion binding]; other site 383372006681 PAS fold; Region: PAS_4; pfam08448 383372006682 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 383372006683 putative active site [active] 383372006684 heme pocket [chemical binding]; other site 383372006685 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 383372006686 PAS domain; Region: PAS_9; pfam13426 383372006687 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 383372006688 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 383372006689 Predicted integral membrane protein (DUF2269); Region: DUF2269; cl02335 383372006690 Cupin domain; Region: Cupin_2; cl09118 383372006691 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 383372006692 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 383372006693 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 383372006694 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 383372006695 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 383372006696 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 383372006697 VanW like protein; Region: VanW; pfam04294 383372006698 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 383372006699 Active_site [active] 383372006700 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 383372006701 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 383372006702 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 383372006703 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 383372006704 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 383372006705 NMT1/THI5 like; Region: NMT1; pfam09084 383372006706 NMT1-like family; Region: NMT1_2; cl15260 383372006707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372006708 dimer interface [polypeptide binding]; other site 383372006709 conserved gate region; other site 383372006710 putative PBP binding loops; other site 383372006711 ABC-ATPase subunit interface; other site 383372006712 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 383372006713 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 383372006714 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 383372006715 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 383372006716 Protein phosphatase 2C; Region: PP2C; pfam00481 383372006717 active site 383372006718 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 383372006719 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 383372006720 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 383372006721 Protein phosphatase 2C; Region: PP2C; pfam00481 383372006722 active site 383372006723 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 383372006724 Protein kinase domain; Region: Pkinase; pfam00069 383372006725 Catalytic domain of Protein Kinases; Region: PKc; cd00180 383372006726 active site 383372006727 ATP binding site [chemical binding]; other site 383372006728 substrate binding site [chemical binding]; other site 383372006729 activation loop (A-loop); other site 383372006730 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 383372006731 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 383372006732 metal ion-dependent adhesion site (MIDAS); other site 383372006733 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 383372006734 Double zinc ribbon; Region: DZR; pfam12773 383372006735 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 383372006736 Double zinc ribbon; Region: DZR; pfam12773 383372006737 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 383372006738 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 383372006739 phosphopeptide binding site; other site 383372006740 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424 383372006741 Uncharacterized protein family (UPF0261); Region: UPF0261; cl02262 383372006742 FixH; Region: FixH; cl01254 383372006743 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 383372006744 intracellular protease, PfpI family; Region: PfpI; TIGR01382 383372006745 proposed catalytic triad [active] 383372006746 conserved cys residue [active] 383372006747 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 383372006748 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 383372006749 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 383372006750 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 383372006751 NAD binding site [chemical binding]; other site 383372006752 catalytic residues [active] 383372006753 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 383372006754 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 383372006755 active site 1 [active] 383372006756 dimer interface [polypeptide binding]; other site 383372006757 hexamer interface [polypeptide binding]; other site 383372006758 active site 2 [active] 383372006759 Flavin Reductases; Region: FlaRed; cl00801 383372006760 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 383372006761 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 383372006762 active site 383372006763 catalytic residues [active] 383372006764 metal binding site [ion binding]; metal-binding site 383372006765 DmpG-like communication domain; Region: DmpG_comm; pfam07836 383372006766 acetaldehyde dehydrogenase; Validated; Region: PRK08300 383372006767 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372006768 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 383372006769 Transcriptional regulator [Transcription]; Region: IclR; COG1414 383372006770 Helix-turn-helix domains; Region: HTH; cl00088 383372006771 Bacterial transcriptional regulator; Region: IclR; pfam01614 383372006772 N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013 383372006773 tetramer interface [polypeptide binding]; other site 383372006774 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 383372006775 C-terminal, catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_C_like; cd09014 383372006776 tetramer interface [polypeptide binding]; other site 383372006777 active site 383372006778 metal binding site [ion binding]; metal-binding site 383372006779 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 383372006780 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 383372006781 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 383372006782 active site 383372006783 NTP binding site [chemical binding]; other site 383372006784 metal binding triad [ion binding]; metal-binding site 383372006785 antibiotic binding site [chemical binding]; other site 383372006786 Protein of unknown function DUF86; Region: DUF86; cl01031 383372006787 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 383372006788 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 383372006789 Walker A/P-loop; other site 383372006790 ATP binding site [chemical binding]; other site 383372006791 Q-loop/lid; other site 383372006792 ABC transporter signature motif; other site 383372006793 Walker B; other site 383372006794 D-loop; other site 383372006795 H-loop/switch region; other site 383372006796 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 383372006797 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 383372006798 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 383372006799 Walker A/P-loop; other site 383372006800 ATP binding site [chemical binding]; other site 383372006801 Q-loop/lid; other site 383372006802 ABC transporter signature motif; other site 383372006803 Walker B; other site 383372006804 D-loop; other site 383372006805 H-loop/switch region; other site 383372006806 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 383372006807 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 383372006808 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 383372006809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372006810 dimer interface [polypeptide binding]; other site 383372006811 conserved gate region; other site 383372006812 putative PBP binding loops; other site 383372006813 ABC-ATPase subunit interface; other site 383372006814 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 383372006815 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372006816 dimer interface [polypeptide binding]; other site 383372006817 conserved gate region; other site 383372006818 putative PBP binding loops; other site 383372006819 ABC-ATPase subunit interface; other site 383372006820 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 383372006821 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 383372006822 DNA polymerase III PolC; Validated; Region: polC; PRK00448 383372006823 peptide chain release factor 1; Validated; Region: prfA; PRK00591 383372006824 RF-1 domain; Region: RF-1; cl02875 383372006825 RF-1 domain; Region: RF-1; cl02875 383372006826 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 383372006827 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 383372006828 active site 383372006829 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 383372006830 catalytic center binding site [active] 383372006831 ATP binding site [chemical binding]; other site 383372006832 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 383372006833 hydrophobic ligand binding site; other site 383372006834 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 383372006835 active site 383372006836 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 383372006837 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 383372006838 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372006839 dihydroorotase; Validated; Region: pyrC; PRK09357 383372006840 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 383372006841 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 383372006842 active site 383372006843 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 383372006844 FAD binding pocket [chemical binding]; other site 383372006845 conserved FAD binding motif [chemical binding]; other site 383372006846 phosphate binding motif [ion binding]; other site 383372006847 beta-alpha-beta structure motif; other site 383372006848 NAD binding pocket [chemical binding]; other site 383372006849 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 383372006850 quinone interaction residues [chemical binding]; other site 383372006851 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 383372006852 active site 383372006853 catalytic residues [active] 383372006854 FMN binding site [chemical binding]; other site 383372006855 substrate binding site [chemical binding]; other site 383372006856 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 383372006857 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 383372006858 active site 383372006859 octamer interface [polypeptide binding]; other site 383372006860 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 383372006861 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 383372006862 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 383372006863 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372006864 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 383372006865 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 383372006866 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372006867 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 383372006868 Cupin domain; Region: Cupin_2; cl09118 383372006869 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 383372006870 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 383372006871 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 383372006872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372006873 NAD(P) binding site [chemical binding]; other site 383372006874 LDH/MDH dimer interface [polypeptide binding]; other site 383372006875 substrate binding site [chemical binding]; other site 383372006876 bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975 383372006877 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 383372006878 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 383372006879 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 383372006880 Walker A/P-loop; other site 383372006881 ATP binding site [chemical binding]; other site 383372006882 Q-loop/lid; other site 383372006883 ABC transporter signature motif; other site 383372006884 Walker B; other site 383372006885 D-loop; other site 383372006886 H-loop/switch region; other site 383372006887 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 383372006888 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 383372006889 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 383372006890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372006891 dimer interface [polypeptide binding]; other site 383372006892 conserved gate region; other site 383372006893 putative PBP binding loops; other site 383372006894 ABC-ATPase subunit interface; other site 383372006895 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 383372006896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372006897 dimer interface [polypeptide binding]; other site 383372006898 conserved gate region; other site 383372006899 putative PBP binding loops; other site 383372006900 ABC-ATPase subunit interface; other site 383372006901 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 383372006902 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 383372006903 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 383372006904 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 383372006905 Walker A/P-loop; other site 383372006906 ATP binding site [chemical binding]; other site 383372006907 Q-loop/lid; other site 383372006908 ABC transporter signature motif; other site 383372006909 Walker B; other site 383372006910 D-loop; other site 383372006911 H-loop/switch region; other site 383372006912 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 383372006913 Transcriptional regulators [Transcription]; Region: PurR; COG1609 383372006914 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 383372006915 DNA binding site [nucleotide binding] 383372006916 domain linker motif; other site 383372006917 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 383372006918 dimerization interface [polypeptide binding]; other site 383372006919 ligand binding site [chemical binding]; other site 383372006920 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 383372006921 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372006922 Protein of unknown function (DUF993); Region: DUF993; pfam06187 383372006923 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 383372006924 PAS fold; Region: PAS_4; pfam08448 383372006925 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 383372006926 putative active site [active] 383372006927 heme pocket [chemical binding]; other site 383372006928 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 383372006929 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 383372006930 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 383372006931 active site 383372006932 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 383372006933 active site 383372006934 NTP binding site [chemical binding]; other site 383372006935 metal binding triad [ion binding]; metal-binding site 383372006936 antibiotic binding site [chemical binding]; other site 383372006937 Protein of unknown function DUF86; Region: DUF86; cl01031 383372006938 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 383372006939 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372006940 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 383372006941 DHH family; Region: DHH; pfam01368 383372006942 FOG: CBS domain [General function prediction only]; Region: COG0517 383372006943 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 383372006944 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 383372006945 active site 383372006946 NTP binding site [chemical binding]; other site 383372006947 metal binding triad [ion binding]; metal-binding site 383372006948 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 383372006949 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 383372006950 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 383372006951 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 383372006952 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 383372006953 ATP binding site [chemical binding]; other site 383372006954 putative Mg++ binding site [ion binding]; other site 383372006955 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 383372006956 nucleotide binding region [chemical binding]; other site 383372006957 ATP-binding site [chemical binding]; other site 383372006958 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 383372006959 active site 383372006960 PAS domain S-box; Region: sensory_box; TIGR00229 383372006961 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 383372006962 putative active site [active] 383372006963 heme pocket [chemical binding]; other site 383372006964 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372006965 dimer interface [polypeptide binding]; other site 383372006966 phosphorylation site [posttranslational modification] 383372006967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372006968 ATP binding site [chemical binding]; other site 383372006969 Mg2+ binding site [ion binding]; other site 383372006970 G-X-G motif; other site 383372006971 Response regulator receiver domain; Region: Response_reg; pfam00072 383372006972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372006973 active site 383372006974 phosphorylation site [posttranslational modification] 383372006975 intermolecular recognition site; other site 383372006976 dimerization interface [polypeptide binding]; other site 383372006977 Herpesvirus UL6 like; Region: Herpes_UL6; pfam01763 383372006978 GAF domain; Region: GAF_2; pfam13185 383372006979 GAF domain; Region: GAF; cl15785 383372006980 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 383372006981 GAF domain; Region: GAF; cl15785 383372006982 GAF domain; Region: GAF_2; pfam13185 383372006983 GAF domain; Region: GAF; cl15785 383372006984 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 383372006985 metal binding site [ion binding]; metal-binding site 383372006986 active site 383372006987 I-site; other site 383372006988 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 383372006989 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 383372006990 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 383372006991 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 383372006992 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 383372006993 dimer interface [polypeptide binding]; other site 383372006994 active site 383372006995 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 383372006996 catalytic residues [active] 383372006997 substrate binding site [chemical binding]; other site 383372006998 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 383372006999 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 383372007000 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 383372007001 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 383372007002 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372007003 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 383372007004 homodimer interface [polypeptide binding]; other site 383372007005 substrate-cofactor binding pocket; other site 383372007006 catalytic residue [active] 383372007007 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 383372007008 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 383372007009 dimer interface [polypeptide binding]; other site 383372007010 active site 383372007011 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372007012 putative active site [active] 383372007013 pyruvate phosphate dikinase; Provisional; Region: PRK09279 383372007014 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 383372007015 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 383372007016 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 383372007017 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 383372007018 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 383372007019 Major Facilitator Superfamily; Region: MFS_1; pfam07690 383372007020 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 383372007021 Domain of unknown function DUF20; Region: UPF0118; pfam01594 383372007022 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 383372007023 active site 383372007024 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 383372007025 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372007026 active site 383372007027 phosphorylation site [posttranslational modification] 383372007028 intermolecular recognition site; other site 383372007029 dimerization interface [polypeptide binding]; other site 383372007030 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 383372007031 DNA binding site [nucleotide binding] 383372007032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372007033 NAD(P) binding site [chemical binding]; other site 383372007034 active site 383372007035 Peptidase family M23; Region: Peptidase_M23; pfam01551 383372007036 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 383372007037 Malic enzyme, N-terminal domain; Region: malic; pfam00390 383372007038 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 383372007039 putative NAD(P) binding site [chemical binding]; other site 383372007040 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 383372007041 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 383372007042 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 383372007043 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 383372007044 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 383372007045 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 383372007046 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 383372007047 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 383372007048 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 383372007049 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 383372007050 dimerization interface [polypeptide binding]; other site 383372007051 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 383372007052 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 383372007053 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 383372007054 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 383372007055 Walker A/P-loop; other site 383372007056 ATP binding site [chemical binding]; other site 383372007057 Q-loop/lid; other site 383372007058 ABC transporter signature motif; other site 383372007059 Walker B; other site 383372007060 D-loop; other site 383372007061 H-loop/switch region; other site 383372007062 Domain of unknown function (DUF385); Region: DUF385; cl04387 383372007063 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 383372007064 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 383372007065 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372007066 Walker A/P-loop; other site 383372007067 ATP binding site [chemical binding]; other site 383372007068 Q-loop/lid; other site 383372007069 ABC transporter signature motif; other site 383372007070 Walker B; other site 383372007071 D-loop; other site 383372007072 H-loop/switch region; other site 383372007073 Helix-turn-helix domains; Region: HTH; cl00088 383372007074 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 383372007075 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 383372007076 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 383372007077 K+-transporting ATPase, B subunit; Region: kdpB; TIGR01497 383372007078 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372007079 S-adenosylmethionine binding site [chemical binding]; other site 383372007080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372007081 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 383372007082 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 383372007083 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 383372007084 MoxR-like ATPases [General function prediction only]; Region: COG0714 383372007085 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 383372007086 Walker A motif; other site 383372007087 ATP binding site [chemical binding]; other site 383372007088 Walker B motif; other site 383372007089 arginine finger; other site 383372007090 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 383372007091 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 383372007092 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 383372007093 active site 383372007094 ADP/pyrophosphate binding site [chemical binding]; other site 383372007095 dimerization interface [polypeptide binding]; other site 383372007096 allosteric effector site; other site 383372007097 fructose-1,6-bisphosphate binding site; other site 383372007098 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 383372007099 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 383372007100 active site 383372007101 ADP/pyrophosphate binding site [chemical binding]; other site 383372007102 dimerization interface [polypeptide binding]; other site 383372007103 allosteric effector site; other site 383372007104 fructose-1,6-bisphosphate binding site; other site 383372007105 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 383372007106 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 383372007107 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372007108 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 383372007109 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 383372007110 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 383372007111 MgtE intracellular N domain; Region: MgtE_N; cl15244 383372007112 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 383372007113 Divalent cation transporter; Region: MgtE; cl00786 383372007114 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 383372007115 phosphopeptide binding site; other site 383372007116 Peptidase C26; Region: Peptidase_C26; pfam07722 383372007117 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 383372007118 catalytic triad [active] 383372007119 AIR carboxylase; Region: AIRC; cl00310 383372007120 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 383372007121 ATP-grasp domain; Region: ATP-grasp_4; cl03087 383372007122 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 383372007123 tandem repeat interface [polypeptide binding]; other site 383372007124 oligomer interface [polypeptide binding]; other site 383372007125 active site residues [active] 383372007126 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 383372007127 tandem repeat interface [polypeptide binding]; other site 383372007128 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 383372007129 oligomer interface [polypeptide binding]; other site 383372007130 active site residues [active] 383372007131 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 383372007132 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 383372007133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 383372007134 NMT1-like family; Region: NMT1_2; cl15260 383372007135 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 383372007136 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 383372007137 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 383372007138 Walker A/P-loop; other site 383372007139 ATP binding site [chemical binding]; other site 383372007140 Q-loop/lid; other site 383372007141 ABC transporter signature motif; other site 383372007142 Walker B; other site 383372007143 D-loop; other site 383372007144 H-loop/switch region; other site 383372007145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372007146 dimer interface [polypeptide binding]; other site 383372007147 conserved gate region; other site 383372007148 putative PBP binding loops; other site 383372007149 ABC-ATPase subunit interface; other site 383372007150 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 383372007151 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372007152 phytoene desaturase; Region: crtI_fam; TIGR02734 383372007153 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 383372007154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372007155 NAD(P) binding site [chemical binding]; other site 383372007156 active site 383372007157 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 383372007158 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 383372007159 FtsX-like permease family; Region: FtsX; cl15850 383372007160 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 383372007161 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 383372007162 active site 383372007163 catalytic residues [active] 383372007164 magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031 383372007165 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 383372007166 metal ion-dependent adhesion site (MIDAS); other site 383372007167 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 383372007168 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 383372007169 phosphopeptide binding site; other site 383372007170 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 383372007171 ParB-like nuclease domain; Region: ParBc; cl02129 383372007172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372007173 dimer interface [polypeptide binding]; other site 383372007174 putative PBP binding loops; other site 383372007175 ABC-ATPase subunit interface; other site 383372007176 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 383372007177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372007178 dimer interface [polypeptide binding]; other site 383372007179 conserved gate region; other site 383372007180 putative PBP binding loops; other site 383372007181 ABC-ATPase subunit interface; other site 383372007182 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 383372007183 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 383372007184 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 383372007185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372007186 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 383372007187 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 383372007188 active site 2 [active] 383372007189 active site 1 [active] 383372007190 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 383372007191 CoA-transferase family III; Region: CoA_transf_3; pfam02515 383372007192 Transcriptional regulators [Transcription]; Region: GntR; COG1802 383372007193 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 383372007194 DNA-binding site [nucleotide binding]; DNA binding site 383372007195 FCD domain; Region: FCD; cl11656 383372007196 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 383372007197 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 383372007198 putative active site pocket [active] 383372007199 metal binding site [ion binding]; metal-binding site 383372007200 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 383372007201 OsmC-like protein; Region: OsmC; cl00767 383372007202 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 383372007203 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 383372007204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 383372007205 Walker A motif; other site 383372007206 ATP binding site [chemical binding]; other site 383372007207 Walker B motif; other site 383372007208 arginine finger; other site 383372007209 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 383372007210 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 383372007211 putative dimer interface [polypeptide binding]; other site 383372007212 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 383372007213 putative active site [active] 383372007214 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 383372007215 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 383372007216 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 383372007217 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372007218 S-adenosylmethionine binding site [chemical binding]; other site 383372007219 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 383372007220 RNA/DNA hybrid binding site [nucleotide binding]; other site 383372007221 active site 383372007222 NeuB family; Region: NeuB; cl00496 383372007223 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 383372007224 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 383372007225 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 383372007226 substrate binding site [chemical binding]; other site 383372007227 ATP binding site [chemical binding]; other site 383372007228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372007229 S-adenosylmethionine binding site [chemical binding]; other site 383372007230 RNA polymerase sigma factor; Provisional; Region: PRK11924 383372007231 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 383372007232 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 383372007233 DNA binding residues [nucleotide binding] 383372007234 Putative zinc-finger; Region: zf-HC2; cl15806 383372007235 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 383372007236 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 383372007237 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 383372007238 DNA binding residues [nucleotide binding] 383372007239 Putative zinc-finger; Region: zf-HC2; cl15806 383372007240 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 383372007241 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 383372007242 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 383372007243 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 383372007244 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 383372007245 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 383372007246 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 383372007247 metal ion-dependent adhesion site (MIDAS); other site 383372007248 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 383372007249 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 383372007250 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 383372007251 metal ion-dependent adhesion site (MIDAS); other site 383372007252 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 383372007253 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 383372007254 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 383372007255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372007256 S-adenosylmethionine binding site [chemical binding]; other site 383372007257 Major Facilitator Superfamily; Region: MFS_1; pfam07690 383372007258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 383372007259 putative substrate translocation pore; other site 383372007260 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 383372007261 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 383372007262 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 383372007263 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 383372007264 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 383372007265 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 383372007266 EamA-like transporter family; Region: EamA; cl01037 383372007267 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 383372007268 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 383372007269 Domain interface; other site 383372007270 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 383372007271 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 383372007272 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 383372007273 Glucose dehydrogenase; Region: glucose_DH; cd08230 383372007274 NADP binding site [chemical binding]; other site 383372007275 catalytic Zn binding site [ion binding]; other site 383372007276 structural Zn binding site [ion binding]; other site 383372007277 dimer interface [polypeptide binding]; other site 383372007278 MFS_1 like family; Region: MFS_1_like; pfam12832 383372007279 Major Facilitator Superfamily; Region: MFS_1; pfam07690 383372007280 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 383372007281 putative active site [active] 383372007282 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 383372007283 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 383372007284 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 383372007285 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 383372007286 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 383372007287 dimerization interface [polypeptide binding]; other site 383372007288 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372007289 dimer interface [polypeptide binding]; other site 383372007290 phosphorylation site [posttranslational modification] 383372007291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372007292 ATP binding site [chemical binding]; other site 383372007293 Mg2+ binding site [ion binding]; other site 383372007294 G-X-G motif; other site 383372007295 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 383372007296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372007297 active site 383372007298 phosphorylation site [posttranslational modification] 383372007299 intermolecular recognition site; other site 383372007300 dimerization interface [polypeptide binding]; other site 383372007301 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 383372007302 DNA binding site [nucleotide binding] 383372007303 Bacterial Ig-like domain; Region: Big_5; cl01012 383372007304 Bacterial Ig-like domain; Region: Big_5; cl01012 383372007305 Bacterial Ig-like domain; Region: Big_5; cl01012 383372007306 Bacterial Ig-like domain; Region: Big_5; cl01012 383372007307 Bacterial Ig-like domain; Region: Big_5; cl01012 383372007308 Bacterial Ig-like domain; Region: Big_5; cl01012 383372007309 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 383372007310 MG2 domain; Region: A2M_N; pfam01835 383372007311 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 383372007312 Alpha-2-macroglobulin family; Region: A2M; pfam00207 383372007313 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 383372007314 surface patch; other site 383372007315 thioester region; other site 383372007316 specificity defining residues; other site 383372007317 Transglycosylase; Region: Transgly; cl07896 383372007318 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 383372007319 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 383372007320 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 383372007321 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 383372007322 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 383372007323 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 383372007324 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 383372007325 Flagellin N-methylase; Region: FliB; cl00497 383372007326 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372007327 TPR motif; other site 383372007328 binding surface 383372007329 Tetratricopeptide repeat; Region: TPR_9; pfam13371 383372007330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 383372007331 putative substrate translocation pore; other site 383372007332 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 383372007333 active site 383372007334 metal binding site [ion binding]; metal-binding site 383372007335 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 383372007336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372007337 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 383372007338 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 383372007339 mannonate dehydratase; Region: uxuA; TIGR00695 383372007340 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 383372007341 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 383372007342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372007343 NAD(P) binding site [chemical binding]; other site 383372007344 active site 383372007345 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 383372007346 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 383372007347 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 383372007348 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 383372007349 polycystin cation channel protein; Region: PCC; TIGR00864 383372007350 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 383372007351 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 383372007352 N- and C-terminal domain interface [polypeptide binding]; other site 383372007353 D-xylulose kinase; Region: XylB; TIGR01312 383372007354 active site 383372007355 catalytic site [active] 383372007356 metal binding site [ion binding]; metal-binding site 383372007357 xylulose binding site [chemical binding]; other site 383372007358 putative ATP binding site [chemical binding]; other site 383372007359 homodimer interface [polypeptide binding]; other site 383372007360 VanW like protein; Region: VanW; pfam04294 383372007361 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 383372007362 homotrimer interaction site [polypeptide binding]; other site 383372007363 putative active site [active] 383372007364 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 383372007365 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 383372007366 conserved cys residue [active] 383372007367 Uncharacterized conserved protein [Function unknown]; Region: COG5476 383372007368 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 383372007369 MlrC C-terminus; Region: MlrC_C; pfam07171 383372007370 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 383372007371 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 383372007372 inhibitor-cofactor binding pocket; inhibition site 383372007373 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372007374 catalytic residue [active] 383372007375 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 383372007376 Cytochrome c; Region: Cytochrom_C; cl11414 383372007377 Bacterial Ig-like domain; Region: Big_5; cl01012 383372007378 Copper resistance protein D; Region: CopD; cl00563 383372007379 Bacterial Ig-like domain; Region: Big_5; cl01012 383372007380 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 383372007381 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 383372007382 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 383372007383 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 383372007384 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372007385 dimer interface [polypeptide binding]; other site 383372007386 phosphorylation site [posttranslational modification] 383372007387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372007388 ATP binding site [chemical binding]; other site 383372007389 Mg2+ binding site [ion binding]; other site 383372007390 G-X-G motif; other site 383372007391 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 383372007392 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 383372007393 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 383372007394 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 383372007395 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 383372007396 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 383372007397 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 383372007398 Small T antigen; Reviewed; Region: PHA03102 383372007399 enterobactin exporter EntS; Provisional; Region: PRK10489 383372007400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 383372007401 putative substrate translocation pore; other site 383372007402 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 383372007403 Herpes virus major outer envelope glycoprotein (BLLF1); Region: Herpes_BLLF1; pfam05109 383372007404 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 383372007405 Helix-turn-helix domains; Region: HTH; cl00088 383372007406 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372007407 binding surface 383372007408 TPR motif; other site 383372007409 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 383372007410 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 383372007411 NAD binding site [chemical binding]; other site 383372007412 homodimer interface [polypeptide binding]; other site 383372007413 active site 383372007414 substrate binding site [chemical binding]; other site 383372007415 CpXC protein; Region: CpXC; pfam14353 383372007416 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 383372007417 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 383372007418 dimer interface [polypeptide binding]; other site 383372007419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372007420 catalytic residue [active] 383372007421 TMAO/DMSO reductase; Reviewed; Region: PRK05363 383372007422 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 383372007423 Moco binding site; other site 383372007424 metal coordination site [ion binding]; other site 383372007425 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 383372007426 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 383372007427 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 383372007428 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 383372007429 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 383372007430 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 383372007431 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 383372007432 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372007433 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 383372007434 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 383372007435 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372007436 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 383372007437 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 383372007438 PAS fold; Region: PAS_4; pfam08448 383372007439 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 383372007440 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 383372007441 putative active site [active] 383372007442 heme pocket [chemical binding]; other site 383372007443 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372007444 dimer interface [polypeptide binding]; other site 383372007445 phosphorylation site [posttranslational modification] 383372007446 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372007447 ATP binding site [chemical binding]; other site 383372007448 Mg2+ binding site [ion binding]; other site 383372007449 G-X-G motif; other site 383372007450 Response regulator receiver domain; Region: Response_reg; pfam00072 383372007451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372007452 active site 383372007453 phosphorylation site [posttranslational modification] 383372007454 intermolecular recognition site; other site 383372007455 dimerization interface [polypeptide binding]; other site 383372007456 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 383372007457 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 383372007458 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 383372007459 putative active site [active] 383372007460 heme pocket [chemical binding]; other site 383372007461 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372007462 dimer interface [polypeptide binding]; other site 383372007463 phosphorylation site [posttranslational modification] 383372007464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372007465 ATP binding site [chemical binding]; other site 383372007466 Mg2+ binding site [ion binding]; other site 383372007467 G-X-G motif; other site 383372007468 Response regulator receiver domain; Region: Response_reg; pfam00072 383372007469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372007470 active site 383372007471 phosphorylation site [posttranslational modification] 383372007472 intermolecular recognition site; other site 383372007473 dimerization interface [polypeptide binding]; other site 383372007474 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 383372007475 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 383372007476 putative ligand binding site [chemical binding]; other site 383372007477 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 383372007478 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 383372007479 Walker A/P-loop; other site 383372007480 ATP binding site [chemical binding]; other site 383372007481 Q-loop/lid; other site 383372007482 ABC transporter signature motif; other site 383372007483 Walker B; other site 383372007484 D-loop; other site 383372007485 H-loop/switch region; other site 383372007486 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 383372007487 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 383372007488 TM-ABC transporter signature motif; other site 383372007489 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 383372007490 TM-ABC transporter signature motif; other site 383372007491 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 383372007492 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 383372007493 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 383372007494 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 383372007495 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 383372007496 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 383372007497 amidase catalytic site [active] 383372007498 Zn binding residues [ion binding]; other site 383372007499 substrate binding site [chemical binding]; other site 383372007500 WYL domain; Region: WYL; cl14852 383372007501 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 383372007502 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 383372007503 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 383372007504 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 383372007505 metal ion-dependent adhesion site (MIDAS); other site 383372007506 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 383372007507 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 383372007508 putative active site [active] 383372007509 putative NTP binding site [chemical binding]; other site 383372007510 putative nucleic acid binding site [nucleotide binding]; other site 383372007511 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 383372007512 putative active site [active] 383372007513 putative nucleic acid binding site [nucleotide binding]; other site 383372007514 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 383372007515 RNA/DNA hybrid binding site [nucleotide binding]; other site 383372007516 active site 383372007517 CRISPR/Cas system-associated protein Csx15; Region: Csx15_I-U; cd09766 383372007518 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 383372007519 WYL domain; Region: WYL; cl14852 383372007520 CRISPR-associated protein (Cas_Cas02710); Region: Cas_Cas02710; pfam09670 383372007521 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09747 383372007522 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 383372007523 nucleoside/Zn binding site; other site 383372007524 dimer interface [polypeptide binding]; other site 383372007525 catalytic motif [active] 383372007526 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372007527 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 383372007528 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 383372007529 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 383372007530 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 383372007531 N-acetyl-D-glucosamine binding site [chemical binding]; other site 383372007532 catalytic residue [active] 383372007533 Protein of unknown function (DUF507); Region: DUF507; cl01112 383372007534 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 383372007535 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 383372007536 Metal-binding active site; metal-binding site 383372007537 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 383372007538 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441 383372007539 GIY-YIG motif/motif A; other site 383372007540 putative active site [active] 383372007541 putative metal binding site [ion binding]; other site 383372007542 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 383372007543 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372007544 Walker A/P-loop; other site 383372007545 ATP binding site [chemical binding]; other site 383372007546 Q-loop/lid; other site 383372007547 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 383372007548 ABC transporter signature motif; other site 383372007549 Walker B; other site 383372007550 ABC transporter; Region: ABC_tran_2; pfam12848 383372007551 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 383372007552 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 383372007553 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 383372007554 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 383372007555 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 383372007556 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 383372007557 Walker A/P-loop; other site 383372007558 ATP binding site [chemical binding]; other site 383372007559 Q-loop/lid; other site 383372007560 ABC transporter signature motif; other site 383372007561 Walker B; other site 383372007562 D-loop; other site 383372007563 H-loop/switch region; other site 383372007564 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372007565 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 383372007566 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 383372007567 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 383372007568 Coenzyme A binding pocket [chemical binding]; other site 383372007569 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 383372007570 Helix-turn-helix domains; Region: HTH; cl00088 383372007571 primosome assembly protein PriA; Validated; Region: PRK05580 383372007572 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 383372007573 ATP binding site [chemical binding]; other site 383372007574 putative Mg++ binding site [ion binding]; other site 383372007575 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372007576 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 383372007577 intersubunit interface [polypeptide binding]; other site 383372007578 active site 383372007579 catalytic residue [active] 383372007580 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 383372007581 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 383372007582 [2Fe-2S] cluster binding site [ion binding]; other site 383372007583 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 383372007584 multidrug resistance protein MdtN; Provisional; Region: PRK10476 383372007585 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 383372007586 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 383372007587 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 383372007588 Walker A/P-loop; other site 383372007589 ATP binding site [chemical binding]; other site 383372007590 Q-loop/lid; other site 383372007591 ABC transporter signature motif; other site 383372007592 Walker B; other site 383372007593 D-loop; other site 383372007594 H-loop/switch region; other site 383372007595 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 383372007596 ligand binding site [chemical binding]; other site 383372007597 flexible hinge region; other site 383372007598 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 383372007599 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372007600 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 383372007601 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 383372007602 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 383372007603 putative substrate binding pocket [chemical binding]; other site 383372007604 dimer interface [polypeptide binding]; other site 383372007605 phosphate binding site [ion binding]; other site 383372007606 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 383372007607 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 383372007608 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 383372007609 substrate binding pocket [chemical binding]; other site 383372007610 substrate-Mg2+ binding site; other site 383372007611 aspartate-rich region 1; other site 383372007612 aspartate-rich region 2; other site 383372007613 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 383372007614 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 383372007615 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cl00425 383372007616 phosphate binding site [ion binding]; other site 383372007617 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 383372007618 active site 383372007619 metal binding site [ion binding]; metal-binding site 383372007620 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 383372007621 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 383372007622 active site 383372007623 substrate binding site [chemical binding]; other site 383372007624 metal binding site [ion binding]; metal-binding site 383372007625 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 383372007626 O-Antigen ligase; Region: Wzy_C; cl04850 383372007627 PAS domain S-box; Region: sensory_box; TIGR00229 383372007628 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 383372007629 putative active site [active] 383372007630 heme pocket [chemical binding]; other site 383372007631 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 383372007632 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 383372007633 putative active site [active] 383372007634 heme pocket [chemical binding]; other site 383372007635 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372007636 dimer interface [polypeptide binding]; other site 383372007637 phosphorylation site [posttranslational modification] 383372007638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372007639 ATP binding site [chemical binding]; other site 383372007640 Mg2+ binding site [ion binding]; other site 383372007641 G-X-G motif; other site 383372007642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372007643 Response regulator receiver domain; Region: Response_reg; pfam00072 383372007644 active site 383372007645 phosphorylation site [posttranslational modification] 383372007646 intermolecular recognition site; other site 383372007647 dimerization interface [polypeptide binding]; other site 383372007648 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 383372007649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 383372007650 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 383372007651 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 383372007652 TIGR01177 family protein; Region: TIGR01177 383372007653 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349; Region: Frankia_peptide; pfam14407 383372007654 cyclase homology domain; Region: CHD; cd07302 383372007655 nucleotidyl binding site; other site 383372007656 metal binding site [ion binding]; metal-binding site 383372007657 dimer interface [polypeptide binding]; other site 383372007658 cyclase homology domain; Region: CHD; cd07302 383372007659 nucleotidyl binding site; other site 383372007660 metal binding site [ion binding]; metal-binding site 383372007661 dimer interface [polypeptide binding]; other site 383372007662 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372007663 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372007664 TPR motif; other site 383372007665 Tetratricopeptide repeat; Region: TPR_12; pfam13424 383372007666 binding surface 383372007667 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372007668 binding surface 383372007669 Tetratricopeptide repeat; Region: TPR_12; pfam13424 383372007670 TPR motif; other site 383372007671 Tetratricopeptide repeat; Region: TPR_12; pfam13424 383372007672 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372007673 binding surface 383372007674 TPR motif; other site 383372007675 Tetratricopeptide repeat; Region: TPR_12; pfam13424 383372007676 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 383372007677 putative DNA binding site [nucleotide binding]; other site 383372007678 dimerization interface [polypeptide binding]; other site 383372007679 putative Zn2+ binding site [ion binding]; other site 383372007680 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 383372007681 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 383372007682 Walker A/P-loop; other site 383372007683 ATP binding site [chemical binding]; other site 383372007684 Q-loop/lid; other site 383372007685 ABC transporter signature motif; other site 383372007686 Walker B; other site 383372007687 D-loop; other site 383372007688 H-loop/switch region; other site 383372007689 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 383372007690 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 383372007691 proton-translocating NADH-quinone oxidoreductase, chain N; Region: NDH_I_N; TIGR01770 383372007692 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 383372007693 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 383372007694 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 383372007695 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 383372007696 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 383372007697 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372007698 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 383372007699 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 383372007700 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 383372007701 Probable Catalytic site; other site 383372007702 metal-binding site 383372007703 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 383372007704 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 383372007705 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 383372007706 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 383372007707 active site 383372007708 metal binding site [ion binding]; metal-binding site 383372007709 homotetramer interface [polypeptide binding]; other site 383372007710 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 383372007711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 383372007712 putative substrate translocation pore; other site 383372007713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 383372007714 putative substrate translocation pore; other site 383372007715 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 383372007716 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 383372007717 metal binding site [ion binding]; metal-binding site 383372007718 active site 383372007719 I-site; other site 383372007720 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 383372007721 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 383372007722 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 383372007723 Family description; Region: VCBS; pfam13517 383372007724 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 383372007725 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 383372007726 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 383372007727 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372007728 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 383372007729 hypothetical protein; Provisional; Region: PRK02947 383372007730 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 383372007731 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 383372007732 putative active site [active] 383372007733 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 383372007734 classical (c) SDRs; Region: SDR_c; cd05233 383372007735 NAD(P) binding site [chemical binding]; other site 383372007736 active site 383372007737 methionine synthase; Provisional; Region: PRK01207 383372007738 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 383372007739 substrate binding site [chemical binding]; other site 383372007740 THF binding site; other site 383372007741 zinc-binding site [ion binding]; other site 383372007742 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 383372007743 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 383372007744 EamA-like transporter family; Region: EamA; cl01037 383372007745 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 383372007746 metal ion-dependent adhesion site (MIDAS); other site 383372007747 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 383372007748 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 383372007749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372007750 catalytic residue [active] 383372007751 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 383372007752 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 383372007753 minor groove reading motif; other site 383372007754 helix-hairpin-helix signature motif; other site 383372007755 substrate binding pocket [chemical binding]; other site 383372007756 active site 383372007757 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 383372007758 magnesium chelatase, H subunit; Region: BchH; TIGR02025 383372007759 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 383372007760 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 383372007761 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 383372007762 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 383372007763 putative acyl-acceptor binding pocket; other site 383372007764 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 383372007765 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 383372007766 active site 383372007767 catalytic triad [active] 383372007768 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 383372007769 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 383372007770 generic binding surface I; other site 383372007771 generic binding surface II; other site 383372007772 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 383372007773 putative active site [active] 383372007774 putative catalytic site [active] 383372007775 putative Mg binding site IVb [ion binding]; other site 383372007776 putative phosphate binding site [ion binding]; other site 383372007777 putative DNA binding site [nucleotide binding]; other site 383372007778 putative Mg binding site IVa [ion binding]; other site 383372007779 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 383372007780 Protein of unknown function (DUF433); Region: DUF433; cl01030 383372007781 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 383372007782 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 383372007783 oligomerisation interface [polypeptide binding]; other site 383372007784 mobile loop; other site 383372007785 roof hairpin; other site 383372007786 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 383372007787 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 383372007788 ring oligomerisation interface [polypeptide binding]; other site 383372007789 ATP/Mg binding site [chemical binding]; other site 383372007790 stacking interactions; other site 383372007791 hinge regions; other site 383372007792 Cytochrome c; Region: Cytochrom_C; cl11414 383372007793 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 383372007794 dimerization interface [polypeptide binding]; other site 383372007795 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372007796 dimer interface [polypeptide binding]; other site 383372007797 phosphorylation site [posttranslational modification] 383372007798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372007799 ATP binding site [chemical binding]; other site 383372007800 Mg2+ binding site [ion binding]; other site 383372007801 G-X-G motif; other site 383372007802 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 383372007803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372007804 active site 383372007805 phosphorylation site [posttranslational modification] 383372007806 intermolecular recognition site; other site 383372007807 dimerization interface [polypeptide binding]; other site 383372007808 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 383372007809 DNA binding site [nucleotide binding] 383372007810 Domain of unknown function (DUF305); Region: DUF305; cl15795 383372007811 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372007812 putative active site [active] 383372007813 Protein of unknown function (DUF507); Region: DUF507; cl01112 383372007814 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 383372007815 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 383372007816 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372007817 active site 383372007818 glycogen synthase; Provisional; Region: glgA; PRK00654 383372007819 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 383372007820 ADP-binding pocket [chemical binding]; other site 383372007821 homodimer interface [polypeptide binding]; other site 383372007822 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 383372007823 PAS fold; Region: PAS_4; pfam08448 383372007824 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 383372007825 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 383372007826 intersubunit interface [polypeptide binding]; other site 383372007827 active site 383372007828 catalytic residue [active] 383372007829 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 383372007830 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372007831 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 383372007832 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 383372007833 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 383372007834 Metal-binding active site; metal-binding site 383372007835 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 383372007836 Moco binding site; other site 383372007837 metal coordination site [ion binding]; other site 383372007838 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 383372007839 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372007840 active site 383372007841 phosphorylation site [posttranslational modification] 383372007842 intermolecular recognition site; other site 383372007843 dimerization interface [polypeptide binding]; other site 383372007844 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 383372007845 DNA binding site [nucleotide binding] 383372007846 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 383372007847 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 383372007848 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372007849 homodimer interface [polypeptide binding]; other site 383372007850 catalytic residue [active] 383372007851 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 383372007852 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372007853 S-adenosylmethionine binding site [chemical binding]; other site 383372007854 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 383372007855 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 383372007856 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 383372007857 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 383372007858 protein binding site [polypeptide binding]; other site 383372007859 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 383372007860 Domain interface; other site 383372007861 Peptide binding site; other site 383372007862 Active site tetrad [active] 383372007863 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 383372007864 peptide binding site [polypeptide binding]; other site 383372007865 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 383372007866 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 383372007867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372007868 dimer interface [polypeptide binding]; other site 383372007869 conserved gate region; other site 383372007870 putative PBP binding loops; other site 383372007871 ABC-ATPase subunit interface; other site 383372007872 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 383372007873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372007874 dimer interface [polypeptide binding]; other site 383372007875 conserved gate region; other site 383372007876 putative PBP binding loops; other site 383372007877 ABC-ATPase subunit interface; other site 383372007878 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 383372007879 dimerization interface [polypeptide binding]; other site 383372007880 putative DNA binding site [nucleotide binding]; other site 383372007881 putative Zn2+ binding site [ion binding]; other site 383372007882 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 383372007883 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 383372007884 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 383372007885 E3 interaction surface; other site 383372007886 lipoyl attachment site [posttranslational modification]; other site 383372007887 e3 binding domain; Region: E3_binding; pfam02817 383372007888 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 383372007889 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 383372007890 Catalytic domain of Protein Kinases; Region: PKc; cd00180 383372007891 active site 383372007892 ATP binding site [chemical binding]; other site 383372007893 substrate binding site [chemical binding]; other site 383372007894 activation loop (A-loop); other site 383372007895 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 383372007896 phosphopeptide binding site; other site 383372007897 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 383372007898 putative active site [active] 383372007899 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 383372007900 phosphopeptide binding site; other site 383372007901 Predicted membrane protein [Function unknown]; Region: COG1470 383372007902 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 383372007903 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 383372007904 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 383372007905 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 383372007906 phosphopeptide binding site; other site 383372007907 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 383372007908 Calx-beta domain; Region: Calx-beta; cl02522 383372007909 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 383372007910 Catalytic domain of Protein Kinases; Region: PKc; cd00180 383372007911 active site 383372007912 ATP binding site [chemical binding]; other site 383372007913 substrate binding site [chemical binding]; other site 383372007914 activation loop (A-loop); other site 383372007915 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 383372007916 phosphopeptide binding site; other site 383372007917 Predicted membrane protein [Function unknown]; Region: COG1470 383372007918 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 383372007919 Catalytic domain of Protein Kinases; Region: PKc; cd00180 383372007920 active site 383372007921 ATP binding site [chemical binding]; other site 383372007922 substrate binding site [chemical binding]; other site 383372007923 activation loop (A-loop); other site 383372007924 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 383372007925 phosphopeptide binding site; other site 383372007926 Predicted membrane protein [Function unknown]; Region: COG1470 383372007927 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 383372007928 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 383372007929 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 383372007930 active site 383372007931 ATP binding site [chemical binding]; other site 383372007932 substrate binding site [chemical binding]; other site 383372007933 activation loop (A-loop); other site 383372007934 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 383372007935 phosphopeptide binding site; other site 383372007936 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 383372007937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372007938 S-adenosylmethionine binding site [chemical binding]; other site 383372007939 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 383372007940 Predicted regulatory domain of a methyltransferase [General function prediction only]; Region: COG4797 383372007941 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 383372007942 phosphopeptide binding site; other site 383372007943 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 383372007944 Baseplate J-like protein; Region: Baseplate_J; cl01294 383372007945 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 383372007946 PAAR motif; Region: PAAR_motif; cl15808 383372007947 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 383372007948 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 383372007949 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 383372007950 putative peptidoglycan binding site; other site 383372007951 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 383372007952 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 383372007953 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 383372007954 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 383372007955 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 383372007956 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 383372007957 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 383372007958 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 383372007959 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 383372007960 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 383372007961 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 383372007962 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 383372007963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 383372007964 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 383372007965 Walker A motif; other site 383372007966 ATP binding site [chemical binding]; other site 383372007967 Walker B motif; other site 383372007968 arginine finger; other site 383372007969 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 383372007970 Right handed beta helix region; Region: Beta_helix; pfam13229 383372007971 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 383372007972 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 383372007973 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 383372007974 DNA binding residues [nucleotide binding] 383372007975 putative dimer interface [polypeptide binding]; other site 383372007976 chaperone protein DnaJ; Provisional; Region: PRK14299 383372007977 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 383372007978 HSP70 interaction site [polypeptide binding]; other site 383372007979 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 383372007980 substrate binding site [polypeptide binding]; other site 383372007981 dimer interface [polypeptide binding]; other site 383372007982 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 383372007983 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 383372007984 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 383372007985 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372007986 dimer interface [polypeptide binding]; other site 383372007987 conserved gate region; other site 383372007988 putative PBP binding loops; other site 383372007989 ABC-ATPase subunit interface; other site 383372007990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372007991 dimer interface [polypeptide binding]; other site 383372007992 conserved gate region; other site 383372007993 putative PBP binding loops; other site 383372007994 ABC-ATPase subunit interface; other site 383372007995 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 383372007996 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 383372007997 Walker A/P-loop; other site 383372007998 ATP binding site [chemical binding]; other site 383372007999 Q-loop/lid; other site 383372008000 ABC transporter signature motif; other site 383372008001 Walker B; other site 383372008002 D-loop; other site 383372008003 H-loop/switch region; other site 383372008004 TOBE domain; Region: TOBE_2; cl01440 383372008005 adhesin; Provisional; Region: PRK09752 383372008006 Fibronectin type III-like domain; Region: Fn3-like; cl15273 383372008007 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 383372008008 CrcB-like protein; Region: CRCB; cl09114 383372008009 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 383372008010 FOG: CBS domain [General function prediction only]; Region: COG0517 383372008011 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 383372008012 FOG: CBS domain [General function prediction only]; Region: COG0517 383372008013 FOG: CBS domain [General function prediction only]; Region: COG0517 383372008014 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 383372008015 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 383372008016 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372008017 Walker A/P-loop; other site 383372008018 ATP binding site [chemical binding]; other site 383372008019 Q-loop/lid; other site 383372008020 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 383372008021 ABC transporter; Region: ABC_tran_2; pfam12848 383372008022 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 383372008023 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 383372008024 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 383372008025 active site 383372008026 substrate-binding site [chemical binding]; other site 383372008027 metal-binding site [ion binding] 383372008028 GTP binding site [chemical binding]; other site 383372008029 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372008030 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 383372008031 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 383372008032 GAF domain; Region: GAF; cl15785 383372008033 GAF domain; Region: GAF_2; pfam13185 383372008034 GAF domain; Region: GAF; cl15785 383372008035 GAF domain; Region: GAF; cl15785 383372008036 GAF domain; Region: GAF; cl15785 383372008037 GAF domain; Region: GAF_2; pfam13185 383372008038 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 383372008039 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 383372008040 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 383372008041 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 383372008042 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 383372008043 Arginase family; Region: Arginase; cl00306 383372008044 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 383372008045 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 383372008046 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 383372008047 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 383372008048 protein binding site [polypeptide binding]; other site 383372008049 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 383372008050 Domain interface; other site 383372008051 Peptide binding site; other site 383372008052 Active site tetrad [active] 383372008053 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 383372008054 active site 383372008055 ribulose/triose binding site [chemical binding]; other site 383372008056 phosphate binding site [ion binding]; other site 383372008057 substrate (anthranilate) binding pocket [chemical binding]; other site 383372008058 product (indole) binding pocket [chemical binding]; other site 383372008059 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 383372008060 amidase; Provisional; Region: PRK07486 383372008061 Amidase; Region: Amidase; cl11426 383372008062 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 383372008063 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 383372008064 Int/Topo IB signature motif; other site 383372008065 active site 383372008066 DNA binding site [nucleotide binding] 383372008067 PemK-like protein; Region: PemK; cl00995 383372008068 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 383372008069 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372008070 active site 383372008071 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 383372008072 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 383372008073 active site 383372008074 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 383372008075 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 383372008076 active site 383372008077 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 383372008078 Acyl transferase domain; Region: Acyl_transf_1; cl08282 383372008079 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 383372008080 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 383372008081 active site 383372008082 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 383372008083 putative NADP binding site [chemical binding]; other site 383372008084 active site 383372008085 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 383372008086 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 383372008087 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 383372008088 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 383372008089 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 383372008090 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 383372008091 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 383372008092 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 383372008093 ATP-grasp domain; Region: ATP-grasp_4; cl03087 383372008094 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 383372008095 pyruvate carboxylase subunit B; Validated; Region: PRK09282 383372008096 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 383372008097 carboxyltransferase (CT) interaction site; other site 383372008098 biotinylation site [posttranslational modification]; other site 383372008099 YcfA-like protein; Region: YcfA; cl00752 383372008100 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 383372008101 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 383372008102 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372008103 putative active site [active] 383372008104 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 383372008105 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 383372008106 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 383372008107 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 383372008108 DNA binding residues [nucleotide binding] 383372008109 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 383372008110 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 383372008111 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 383372008112 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 383372008113 trmE is a tRNA modification GTPase; Region: trmE; cd04164 383372008114 G1 box; other site 383372008115 GTP/Mg2+ binding site [chemical binding]; other site 383372008116 Switch I region; other site 383372008117 G2 box; other site 383372008118 Switch II region; other site 383372008119 G3 box; other site 383372008120 G4 box; other site 383372008121 G5 box; other site 383372008122 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 383372008123 Response regulator receiver domain; Region: Response_reg; pfam00072 383372008124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372008125 active site 383372008126 phosphorylation site [posttranslational modification] 383372008127 intermolecular recognition site; other site 383372008128 dimerization interface [polypeptide binding]; other site 383372008129 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 383372008130 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 383372008131 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372008132 Protein of unknown function (DUF3623); Region: DUF3623; cl11843 383372008133 PUCC protein; Region: PUCC; pfam03209 383372008134 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 383372008135 ligand binding site [chemical binding]; other site 383372008136 flexible hinge region; other site 383372008137 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 383372008138 ligand binding site [chemical binding]; other site 383372008139 flexible hinge region; other site 383372008140 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 383372008141 4Fe-4S binding domain; Region: Fer4; cl02805 383372008142 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 383372008143 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372008144 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 383372008145 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 383372008146 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 383372008147 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 383372008148 dimer interface [polypeptide binding]; other site 383372008149 active site 383372008150 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 383372008151 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 383372008152 carboxyltransferase (CT) interaction site; other site 383372008153 biotinylation site [posttranslational modification]; other site 383372008154 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 383372008155 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 383372008156 generic binding surface II; other site 383372008157 generic binding surface I; other site 383372008158 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 383372008159 Membrane transport protein; Region: Mem_trans; cl09117 383372008160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 383372008161 YGGT family; Region: YGGT; cl00508 383372008162 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 383372008163 histidinol dehydrogenase; Region: hisD; TIGR00069 383372008164 NAD binding site [chemical binding]; other site 383372008165 dimerization interface [polypeptide binding]; other site 383372008166 product binding site; other site 383372008167 substrate binding site [chemical binding]; other site 383372008168 zinc binding site [ion binding]; other site 383372008169 catalytic residues [active] 383372008170 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 383372008171 ATP phosphoribosyltransferase; Region: HisG; cl15266 383372008172 HisG, C-terminal domain; Region: HisG_C; cl06867 383372008173 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372008174 putative active site [active] 383372008175 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372008176 putative active site [active] 383372008177 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 383372008178 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 383372008179 MoxR-like ATPases [General function prediction only]; Region: COG0714 383372008180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 383372008181 Walker A motif; other site 383372008182 ATP binding site [chemical binding]; other site 383372008183 Walker B motif; other site 383372008184 arginine finger; other site 383372008185 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 383372008186 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 383372008187 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 383372008188 motif 1; other site 383372008189 dimer interface [polypeptide binding]; other site 383372008190 motif 2; other site 383372008191 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 383372008192 motif 3; other site 383372008193 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 383372008194 anticodon binding site; other site 383372008195 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 383372008196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372008197 ATP binding site [chemical binding]; other site 383372008198 Mg2+ binding site [ion binding]; other site 383372008199 G-X-G motif; other site 383372008200 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 383372008201 endonuclease III; Region: ENDO3c; smart00478 383372008202 minor groove reading motif; other site 383372008203 helix-hairpin-helix signature motif; other site 383372008204 substrate binding pocket [chemical binding]; other site 383372008205 active site 383372008206 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 383372008207 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 383372008208 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 383372008209 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 383372008210 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 383372008211 putative active site [active] 383372008212 oxyanion strand; other site 383372008213 catalytic triad [active] 383372008214 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 383372008215 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 383372008216 catalytic residues [active] 383372008217 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 383372008218 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 383372008219 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 383372008220 substrate binding site [chemical binding]; other site 383372008221 glutamase interaction surface [polypeptide binding]; other site 383372008222 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 383372008223 MoaE interaction surface [polypeptide binding]; other site 383372008224 MoeB interaction surface [polypeptide binding]; other site 383372008225 thiocarboxylated glycine; other site 383372008226 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 383372008227 MoaE homodimer interface [polypeptide binding]; other site 383372008228 MoaD interaction [polypeptide binding]; other site 383372008229 active site residues [active] 383372008230 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 383372008231 Domain of unknown function DUF21; Region: DUF21; pfam01595 383372008232 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 383372008233 Transporter associated domain; Region: CorC_HlyC; cl08393 383372008234 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 383372008235 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 383372008236 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 383372008237 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 383372008238 classical (c) SDRs; Region: SDR_c; cd05233 383372008239 NAD(P) binding site [chemical binding]; other site 383372008240 active site 383372008241 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372008242 NAD(P) binding site [chemical binding]; other site 383372008243 active site 383372008244 classical (c) SDRs; Region: SDR_c; cd05233 383372008245 NAD(P) binding site [chemical binding]; other site 383372008246 active site 383372008247 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 383372008248 AMP-binding enzyme; Region: AMP-binding; cl15778 383372008249 acyl-CoA synthetase; Validated; Region: PRK07787 383372008250 AMP-binding enzyme; Region: AMP-binding; cl15778 383372008251 acyl-CoA synthetase; Validated; Region: PRK07788 383372008252 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 383372008253 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 383372008254 substrate binding site [chemical binding]; other site 383372008255 oxyanion hole (OAH) forming residues; other site 383372008256 trimer interface [polypeptide binding]; other site 383372008257 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372008258 NAD(P) binding site [chemical binding]; other site 383372008259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372008260 NAD(P) binding site [chemical binding]; other site 383372008261 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 383372008262 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 383372008263 ATP-grasp domain; Region: ATP-grasp_4; cl03087 383372008264 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 383372008265 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 383372008266 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 383372008267 NAD(P) binding site [chemical binding]; other site 383372008268 catalytic residues [active] 383372008269 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 383372008270 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 383372008271 NADP binding site [chemical binding]; other site 383372008272 dimer interface [polypeptide binding]; other site 383372008273 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 383372008274 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 383372008275 protein binding site [polypeptide binding]; other site 383372008276 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 383372008277 Domain interface; other site 383372008278 Peptide binding site; other site 383372008279 Active site tetrad [active] 383372008280 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 383372008281 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 383372008282 intersubunit interface [polypeptide binding]; other site 383372008283 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 383372008284 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 383372008285 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 383372008286 cobalamin binding residues [chemical binding]; other site 383372008287 putative BtuC binding residues; other site 383372008288 dimer interface [polypeptide binding]; other site 383372008289 chaperone protein DnaJ; Provisional; Region: PRK10767 383372008290 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 383372008291 HSP70 interaction site [polypeptide binding]; other site 383372008292 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 383372008293 substrate binding site [polypeptide binding]; other site 383372008294 dimer interface [polypeptide binding]; other site 383372008295 hypothetical protein; Validated; Region: PRK06840 383372008296 Rhomboid family; Region: Rhomboid; cl11446 383372008297 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 383372008298 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 383372008299 active site 383372008300 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 383372008301 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372008302 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372008303 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 383372008304 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 383372008305 catalytic residues [active] 383372008306 dimer interface [polypeptide binding]; other site 383372008307 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 383372008308 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 383372008309 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372008310 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 383372008311 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 383372008312 G8 domain; Region: G8; pfam10162 383372008313 Right handed beta helix region; Region: Beta_helix; pfam13229 383372008314 Protein of unknown function (DUF497); Region: DUF497; cl01108 383372008315 oxaloacetate decarboxylase alpha subunit; Region: oadA; TIGR01108 383372008316 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 383372008317 active site 383372008318 catalytic residues [active] 383372008319 metal binding site [ion binding]; metal-binding site 383372008320 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 383372008321 carboxyltransferase (CT) interaction site; other site 383372008322 biotinylation site [posttranslational modification]; other site 383372008323 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 383372008324 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 383372008325 ATP-grasp domain; Region: ATP-grasp_4; cl03087 383372008326 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 383372008327 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 383372008328 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 383372008329 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 383372008330 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 383372008331 active site 383372008332 catalytic site [active] 383372008333 recombinase A; Provisional; Region: recA; PRK09354 383372008334 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 383372008335 hexamer interface [polypeptide binding]; other site 383372008336 Walker A motif; other site 383372008337 ATP binding site [chemical binding]; other site 383372008338 Walker B motif; other site 383372008339 RecX family; Region: RecX; cl00936 383372008340 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 383372008341 CTP synthetase; Validated; Region: pyrG; PRK05380 383372008342 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 383372008343 Catalytic site [active] 383372008344 active site 383372008345 UTP binding site [chemical binding]; other site 383372008346 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 383372008347 active site 383372008348 putative oxyanion hole; other site 383372008349 catalytic triad [active] 383372008350 hypothetical protein; Provisional; Region: PRK11770 383372008351 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 383372008352 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 383372008353 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 383372008354 Fibronectin type III-like domain; Region: Fn3-like; cl15273 383372008355 Fibronectin type III-like domain; Region: Fn3-like; cl15273 383372008356 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 383372008357 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 383372008358 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 383372008359 catalytic residue [active] 383372008360 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 383372008361 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 383372008362 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 383372008363 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 383372008364 O-Antigen ligase; Region: Wzy_C; cl04850 383372008365 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 383372008366 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 383372008367 putative active site [active] 383372008368 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 383372008369 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 383372008370 GIY-YIG motif/motif A; other site 383372008371 active site 383372008372 catalytic site [active] 383372008373 putative DNA binding site [nucleotide binding]; other site 383372008374 metal binding site [ion binding]; metal-binding site 383372008375 UvrB/uvrC motif; Region: UVR; pfam02151 383372008376 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 383372008377 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 383372008378 Dehydratase family; Region: ILVD_EDD; cl00340 383372008379 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 383372008380 tetramer (dimer of dimers) interface [polypeptide binding]; other site 383372008381 active site 383372008382 dimer interface [polypeptide binding]; other site 383372008383 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 383372008384 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 383372008385 Cu(I) binding site [ion binding]; other site 383372008386 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 383372008387 catalytic loop [active] 383372008388 iron binding site [ion binding]; other site 383372008389 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 383372008390 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 383372008391 ATP binding site [chemical binding]; other site 383372008392 putative Mg++ binding site [ion binding]; other site 383372008393 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372008394 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 383372008395 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 383372008396 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 383372008397 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 383372008398 motif II; other site 383372008399 Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein). Individual proteins of this band 7 domain family may...; Region: Band_7_prohibitin; cd03401 383372008400 adhesin; Provisional; Region: PRK09752 383372008401 adhesin; Provisional; Region: PRK09752 383372008402 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 383372008403 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 383372008404 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 383372008405 catalytic residues [active] 383372008406 prolyl-tRNA synthetase, family II; Region: proS_fam_II; TIGR00409 383372008407 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 383372008408 motif 1; other site 383372008409 dimer interface [polypeptide binding]; other site 383372008410 active site 383372008411 motif 2; other site 383372008412 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 383372008413 putative deacylase active site [active] 383372008414 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 383372008415 anticodon binding site; other site 383372008416 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 383372008417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372008418 S-adenosylmethionine binding site [chemical binding]; other site 383372008419 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 383372008420 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 383372008421 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 383372008422 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 383372008423 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 383372008424 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372008425 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 383372008426 B12 binding site [chemical binding]; other site 383372008427 cobalt ligand [ion binding]; other site 383372008428 LAO/AO transport system ATPase; Region: lao; TIGR00750 383372008429 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 383372008430 Walker A; other site 383372008431 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 383372008432 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 383372008433 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 383372008434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372008435 homodimer interface [polypeptide binding]; other site 383372008436 catalytic residue [active] 383372008437 GAF domain; Region: GAF_2; pfam13185 383372008438 GAF domain; Region: GAF; cl15785 383372008439 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 383372008440 PAS fold; Region: PAS_4; pfam08448 383372008441 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 383372008442 GAF domain; Region: GAF; cl15785 383372008443 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 383372008444 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 383372008445 putative active site [active] 383372008446 heme pocket [chemical binding]; other site 383372008447 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 383372008448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372008449 ATP binding site [chemical binding]; other site 383372008450 Mg2+ binding site [ion binding]; other site 383372008451 G-X-G motif; other site 383372008452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372008453 active site 383372008454 phosphorylation site [posttranslational modification] 383372008455 intermolecular recognition site; other site 383372008456 dimerization interface [polypeptide binding]; other site 383372008457 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 383372008458 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 383372008459 aspartate kinase; Provisional; Region: PRK06291 383372008460 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 383372008461 nucleotide binding site [chemical binding]; other site 383372008462 substrate binding site [chemical binding]; other site 383372008463 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 383372008464 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 383372008465 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 383372008466 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 383372008467 FAD binding site [chemical binding]; other site 383372008468 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 383372008469 Ligand Binding Site [chemical binding]; other site 383372008470 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 383372008471 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 383372008472 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 383372008473 active site 383372008474 HIGH motif; other site 383372008475 KMSKS motif; other site 383372008476 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 383372008477 tRNA binding surface [nucleotide binding]; other site 383372008478 anticodon binding site; other site 383372008479 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 383372008480 active site 383372008481 NTP binding site [chemical binding]; other site 383372008482 metal binding triad [ion binding]; metal-binding site 383372008483 antibiotic binding site [chemical binding]; other site 383372008484 Protein of unknown function DUF86; Region: DUF86; cl01031 383372008485 Cupin domain; Region: Cupin_2; cl09118 383372008486 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 383372008487 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 383372008488 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 383372008489 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 383372008490 Ligand Binding Site [chemical binding]; other site 383372008491 Molecular Tunnel; other site 383372008492 hypothetical protein; Validated; Region: PRK06201 383372008493 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 383372008494 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 383372008495 Fructose-1,6-bisphosphatase; Region: FBPase_3; cl00862 383372008496 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 383372008497 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 383372008498 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 383372008499 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 383372008500 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 383372008501 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 383372008502 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372008503 dimer interface [polypeptide binding]; other site 383372008504 phosphorylation site [posttranslational modification] 383372008505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372008506 ATP binding site [chemical binding]; other site 383372008507 Mg2+ binding site [ion binding]; other site 383372008508 G-X-G motif; other site 383372008509 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 383372008510 transmembrane helices; other site 383372008511 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 383372008512 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 383372008513 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 383372008514 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 383372008515 active site 383372008516 metal binding site [ion binding]; metal-binding site 383372008517 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 383372008518 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 383372008519 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 383372008520 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 383372008521 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 383372008522 Catalytic domain of Protein Kinases; Region: PKc; cd00180 383372008523 active site 383372008524 ATP binding site [chemical binding]; other site 383372008525 substrate binding site [chemical binding]; other site 383372008526 activation loop (A-loop); other site 383372008527 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 383372008528 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 383372008529 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 383372008530 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 383372008531 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 383372008532 active site 383372008533 tetramer interface [polypeptide binding]; other site 383372008534 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 383372008535 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 383372008536 Walker A/P-loop; other site 383372008537 ATP binding site [chemical binding]; other site 383372008538 Q-loop/lid; other site 383372008539 ABC transporter signature motif; other site 383372008540 Walker B; other site 383372008541 D-loop; other site 383372008542 H-loop/switch region; other site 383372008543 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 383372008544 HSP70 interaction site [polypeptide binding]; other site 383372008545 TPR repeat; Region: TPR_11; pfam13414 383372008546 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 383372008547 Double zinc ribbon; Region: DZR; pfam12773 383372008548 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 383372008549 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 383372008550 phosphopeptide binding site; other site 383372008551 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 383372008552 dimer interface [polypeptide binding]; other site 383372008553 ADP-ribose binding site [chemical binding]; other site 383372008554 active site 383372008555 nudix motif; other site 383372008556 metal binding site [ion binding]; metal-binding site 383372008557 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 383372008558 Peptidase C26; Region: Peptidase_C26; pfam07722 383372008559 catalytic triad [active] 383372008560 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 383372008561 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 383372008562 Coenzyme A binding pocket [chemical binding]; other site 383372008563 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 383372008564 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 383372008565 active site 383372008566 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 383372008567 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 383372008568 Walker A motif; other site 383372008569 ATP binding site [chemical binding]; other site 383372008570 Walker B motif; other site 383372008571 arginine finger; other site 383372008572 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 383372008573 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 383372008574 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 383372008575 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372008576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372008577 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 383372008578 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 383372008579 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 383372008580 Walker A/P-loop; other site 383372008581 ATP binding site [chemical binding]; other site 383372008582 Q-loop/lid; other site 383372008583 ABC transporter signature motif; other site 383372008584 Walker B; other site 383372008585 D-loop; other site 383372008586 H-loop/switch region; other site 383372008587 ABC-2 type transporter; Region: ABC2_membrane; cl11417 383372008588 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 383372008589 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 383372008590 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 383372008591 alpha subunit interface [polypeptide binding]; other site 383372008592 TPP binding site [chemical binding]; other site 383372008593 heterodimer interface [polypeptide binding]; other site 383372008594 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 383372008595 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 383372008596 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 383372008597 tetramer interface [polypeptide binding]; other site 383372008598 TPP-binding site [chemical binding]; other site 383372008599 heterodimer interface [polypeptide binding]; other site 383372008600 phosphorylation loop region [posttranslational modification] 383372008601 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 383372008602 GAF domain; Region: GAF; cl15785 383372008603 Histidine kinase; Region: HisKA_3; pfam07730 383372008604 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 383372008605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372008606 ATP binding site [chemical binding]; other site 383372008607 Mg2+ binding site [ion binding]; other site 383372008608 G-X-G motif; other site 383372008609 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 383372008610 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372008611 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 383372008612 short chain dehydrogenase; Provisional; Region: PRK06181 383372008613 classical (c) SDRs; Region: SDR_c; cd05233 383372008614 NAD(P) binding site [chemical binding]; other site 383372008615 active site 383372008616 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 383372008617 30S subunit binding site; other site 383372008618 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 383372008619 putative ligand binding pocket/active site [active] 383372008620 putative metal binding site [ion binding]; other site 383372008621 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 383372008622 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 383372008623 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 383372008624 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 383372008625 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372008626 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 383372008627 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 383372008628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372008629 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 383372008630 ornithine carbamoyltransferase; Provisional; Region: PRK00779 383372008631 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 383372008632 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372008633 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 383372008634 argininosuccinate lyase; Provisional; Region: PRK00855 383372008635 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 383372008636 active sites [active] 383372008637 tetramer interface [polypeptide binding]; other site 383372008638 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 383372008639 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 383372008640 putative active site [active] 383372008641 heme pocket [chemical binding]; other site 383372008642 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372008643 dimer interface [polypeptide binding]; other site 383372008644 phosphorylation site [posttranslational modification] 383372008645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372008646 ATP binding site [chemical binding]; other site 383372008647 Mg2+ binding site [ion binding]; other site 383372008648 G-X-G motif; other site 383372008649 Response regulator receiver domain; Region: Response_reg; pfam00072 383372008650 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372008651 active site 383372008652 phosphorylation site [posttranslational modification] 383372008653 intermolecular recognition site; other site 383372008654 dimerization interface [polypeptide binding]; other site 383372008655 Low molecular weight phosphatase family; Region: LMWPc; cl00105 383372008656 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 383372008657 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 383372008658 putative Iron-sulfur protein interface [polypeptide binding]; other site 383372008659 proximal heme binding site [chemical binding]; other site 383372008660 distal heme binding site [chemical binding]; other site 383372008661 putative dimer interface [polypeptide binding]; other site 383372008662 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 383372008663 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372008664 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 383372008665 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 383372008666 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 383372008667 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372008668 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 383372008669 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372008670 NAD(P) binding site [chemical binding]; other site 383372008671 active site 383372008672 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 383372008673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372008674 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 383372008675 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 383372008676 NAD binding site [chemical binding]; other site 383372008677 substrate binding site [chemical binding]; other site 383372008678 homodimer interface [polypeptide binding]; other site 383372008679 active site 383372008680 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 383372008681 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 383372008682 tandem repeat interface [polypeptide binding]; other site 383372008683 oligomer interface [polypeptide binding]; other site 383372008684 active site residues [active] 383372008685 adhesin; Provisional; Region: PRK09752 383372008686 adhesin; Provisional; Region: PRK09752 383372008687 TM1410 hypothetical-related protein; Region: DUF297; cl00997 383372008688 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 383372008689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372008690 S-adenosylmethionine binding site [chemical binding]; other site 383372008691 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 383372008692 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 383372008693 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 383372008694 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 383372008695 hypothetical protein; Provisional; Region: PRK08317 383372008696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372008697 S-adenosylmethionine binding site [chemical binding]; other site 383372008698 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 383372008699 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 383372008700 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372008701 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 383372008702 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 383372008703 extended (e) SDRs; Region: SDR_e; cd08946 383372008704 NAD(P) binding site [chemical binding]; other site 383372008705 active site 383372008706 substrate binding site [chemical binding]; other site 383372008707 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 383372008708 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 383372008709 substrate binding site; other site 383372008710 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 383372008711 active site 383372008712 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 383372008713 dimer interface [polypeptide binding]; other site 383372008714 active site 383372008715 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 383372008716 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 383372008717 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 383372008718 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 383372008719 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 383372008720 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 383372008721 active site 383372008722 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 383372008723 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 383372008724 active site 383372008725 MatE; Region: MatE; cl10513 383372008726 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 383372008727 active site 383372008728 O-Antigen ligase; Region: Wzy_C; cl04850 383372008729 Chain length determinant protein; Region: Wzz; cl15801 383372008730 Chain length determinant protein; Region: Wzz; cl15801 383372008731 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 383372008732 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 383372008733 DXD motif; other site 383372008734 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 383372008735 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 383372008736 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 383372008737 putative ADP-binding pocket [chemical binding]; other site 383372008738 Bacterial sugar transferase; Region: Bac_transf; cl00939 383372008739 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 383372008740 metal binding site [ion binding]; metal-binding site 383372008741 I-site; other site 383372008742 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 383372008743 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 383372008744 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 383372008745 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 383372008746 dimer interface [polypeptide binding]; other site 383372008747 active site 383372008748 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 383372008749 dimer interface [polypeptide binding]; other site 383372008750 active site 383372008751 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 383372008752 GAF domain; Region: GAF; cl15785 383372008753 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372008754 dimer interface [polypeptide binding]; other site 383372008755 phosphorylation site [posttranslational modification] 383372008756 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372008757 ATP binding site [chemical binding]; other site 383372008758 Mg2+ binding site [ion binding]; other site 383372008759 G-X-G motif; other site 383372008760 Right handed beta helix region; Region: Beta_helix; pfam13229 383372008761 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 383372008762 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 383372008763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372008764 active site 383372008765 phosphorylation site [posttranslational modification] 383372008766 intermolecular recognition site; other site 383372008767 dimerization interface [polypeptide binding]; other site 383372008768 ANTAR domain; Region: ANTAR; cl04297 383372008769 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 383372008770 homotrimer interaction site [polypeptide binding]; other site 383372008771 active site 383372008772 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 383372008773 NeuB family; Region: NeuB; cl00496 383372008774 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 383372008775 Family description; Region: VCBS; pfam13517 383372008776 Family description; Region: VCBS; pfam13517 383372008777 Family description; Region: VCBS; pfam13517 383372008778 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 383372008779 Esterase/lipase [General function prediction only]; Region: COG1647 383372008780 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 383372008781 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372008782 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372008783 TPR motif; other site 383372008784 binding surface 383372008785 Bacterial transcriptional activator domain; Region: BTAD; smart01043 383372008786 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 383372008787 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 383372008788 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 383372008789 Walker A/P-loop; other site 383372008790 ATP binding site [chemical binding]; other site 383372008791 Q-loop/lid; other site 383372008792 ABC transporter signature motif; other site 383372008793 Walker B; other site 383372008794 D-loop; other site 383372008795 H-loop/switch region; other site 383372008796 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 383372008797 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 383372008798 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372008799 Walker A/P-loop; other site 383372008800 ATP binding site [chemical binding]; other site 383372008801 Q-loop/lid; other site 383372008802 ABC transporter signature motif; other site 383372008803 Walker B; other site 383372008804 D-loop; other site 383372008805 H-loop/switch region; other site 383372008806 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372008807 dimer interface [polypeptide binding]; other site 383372008808 phosphorylation site [posttranslational modification] 383372008809 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372008810 ATP binding site [chemical binding]; other site 383372008811 Mg2+ binding site [ion binding]; other site 383372008812 G-X-G motif; other site 383372008813 PspC domain; Region: PspC; cl00864 383372008814 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 383372008815 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202 383372008816 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 383372008817 putative NAD(P) binding site [chemical binding]; other site 383372008818 Response regulator receiver domain; Region: Response_reg; pfam00072 383372008819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372008820 active site 383372008821 phosphorylation site [posttranslational modification] 383372008822 intermolecular recognition site; other site 383372008823 dimerization interface [polypeptide binding]; other site 383372008824 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 383372008825 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 383372008826 dimerization interface [polypeptide binding]; other site 383372008827 ligand binding site [chemical binding]; other site 383372008828 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 383372008829 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372008830 dimer interface [polypeptide binding]; other site 383372008831 phosphorylation site [posttranslational modification] 383372008832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372008833 ATP binding site [chemical binding]; other site 383372008834 Mg2+ binding site [ion binding]; other site 383372008835 G-X-G motif; other site 383372008836 Response regulator receiver domain; Region: Response_reg; pfam00072 383372008837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372008838 active site 383372008839 phosphorylation site [posttranslational modification] 383372008840 intermolecular recognition site; other site 383372008841 dimerization interface [polypeptide binding]; other site 383372008842 Response regulator receiver domain; Region: Response_reg; pfam00072 383372008843 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372008844 active site 383372008845 phosphorylation site [posttranslational modification] 383372008846 intermolecular recognition site; other site 383372008847 dimerization interface [polypeptide binding]; other site 383372008848 sensory histidine kinase AtoS; Provisional; Region: PRK11360 383372008849 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 383372008850 PAS fold; Region: PAS_3; pfam08447 383372008851 putative active site [active] 383372008852 heme pocket [chemical binding]; other site 383372008853 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 383372008854 metal binding site [ion binding]; metal-binding site 383372008855 active site 383372008856 I-site; other site 383372008857 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 383372008858 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 383372008859 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 383372008860 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 383372008861 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 383372008862 active site 383372008863 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 383372008864 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 383372008865 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 383372008866 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 383372008867 PHP-associated; Region: PHP_C; pfam13263 383372008868 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 383372008869 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 383372008870 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 383372008871 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 383372008872 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 383372008873 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 383372008874 HflX GTPase family; Region: HflX; cd01878 383372008875 G1 box; other site 383372008876 GTP/Mg2+ binding site [chemical binding]; other site 383372008877 Switch I region; other site 383372008878 G2 box; other site 383372008879 G3 box; other site 383372008880 Switch II region; other site 383372008881 G4 box; other site 383372008882 G5 box; other site 383372008883 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 383372008884 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 383372008885 putative substrate-binding site; other site 383372008886 nickel binding site [ion binding]; other site 383372008887 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 383372008888 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 383372008889 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 383372008890 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 383372008891 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 383372008892 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 383372008893 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 383372008894 Walker A/P-loop; other site 383372008895 ATP binding site [chemical binding]; other site 383372008896 Q-loop/lid; other site 383372008897 ABC transporter signature motif; other site 383372008898 Walker B; other site 383372008899 D-loop; other site 383372008900 H-loop/switch region; other site 383372008901 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 383372008902 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 383372008903 Walker A/P-loop; other site 383372008904 ATP binding site [chemical binding]; other site 383372008905 Q-loop/lid; other site 383372008906 ABC transporter signature motif; other site 383372008907 Walker B; other site 383372008908 D-loop; other site 383372008909 H-loop/switch region; other site 383372008910 FtsX-like permease family; Region: FtsX; cl15850 383372008911 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 383372008912 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 383372008913 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 383372008914 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 383372008915 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 383372008916 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 383372008917 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 383372008918 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 383372008919 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 383372008920 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 383372008921 structural tetrad; other site 383372008922 translocation protein TolB; Provisional; Region: tolB; PRK05137 383372008923 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 383372008924 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 383372008925 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 383372008926 protein binding site [polypeptide binding]; other site 383372008927 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 383372008928 Domain interface; other site 383372008929 Peptide binding site; other site 383372008930 Active site tetrad [active] 383372008931 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 383372008932 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 383372008933 active site 383372008934 catalytic residues [active] 383372008935 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 383372008936 active site 383372008937 putative substrate binding region [chemical binding]; other site 383372008938 FOG: CBS domain [General function prediction only]; Region: COG0517 383372008939 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_26; cd04639 383372008940 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 383372008941 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 383372008942 ligand binding site [chemical binding]; other site 383372008943 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 383372008944 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 383372008945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372008946 active site 383372008947 phosphorylation site [posttranslational modification] 383372008948 intermolecular recognition site; other site 383372008949 dimerization interface [polypeptide binding]; other site 383372008950 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 383372008951 DNA binding site [nucleotide binding] 383372008952 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 383372008953 PAS domain; Region: PAS_9; pfam13426 383372008954 putative active site [active] 383372008955 heme pocket [chemical binding]; other site 383372008956 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 383372008957 PAS domain; Region: PAS_9; pfam13426 383372008958 putative active site [active] 383372008959 heme pocket [chemical binding]; other site 383372008960 sensory histidine kinase AtoS; Provisional; Region: PRK11360 383372008961 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372008962 dimer interface [polypeptide binding]; other site 383372008963 phosphorylation site [posttranslational modification] 383372008964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372008965 ATP binding site [chemical binding]; other site 383372008966 Mg2+ binding site [ion binding]; other site 383372008967 G-X-G motif; other site 383372008968 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 383372008969 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 383372008970 NAD binding site [chemical binding]; other site 383372008971 homotetramer interface [polypeptide binding]; other site 383372008972 homodimer interface [polypeptide binding]; other site 383372008973 active site 383372008974 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 383372008975 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 383372008976 substrate binding site [chemical binding]; other site 383372008977 oxyanion hole (OAH) forming residues; other site 383372008978 trimer interface [polypeptide binding]; other site 383372008979 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 383372008980 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 383372008981 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 383372008982 active site 383372008983 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 383372008984 Ligand binding site [chemical binding]; other site 383372008985 Electron transfer flavoprotein domain; Region: ETF; pfam01012 383372008986 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 383372008987 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 383372008988 Ligand binding site [chemical binding]; other site 383372008989 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 383372008990 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 383372008991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372008992 ATP binding site [chemical binding]; other site 383372008993 Mg2+ binding site [ion binding]; other site 383372008994 G-X-G motif; other site 383372008995 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 383372008996 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 383372008997 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 383372008998 GAF domain; Region: GAF; cl15785 383372008999 GAF domain; Region: GAF; cl15785 383372009000 GAF domain; Region: GAF_2; pfam13185 383372009001 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 383372009002 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 383372009003 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372009004 dimer interface [polypeptide binding]; other site 383372009005 phosphorylation site [posttranslational modification] 383372009006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372009007 ATP binding site [chemical binding]; other site 383372009008 Mg2+ binding site [ion binding]; other site 383372009009 G-X-G motif; other site 383372009010 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 383372009011 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 383372009012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 383372009013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372009014 dimer interface [polypeptide binding]; other site 383372009015 conserved gate region; other site 383372009016 putative PBP binding loops; other site 383372009017 ABC-ATPase subunit interface; other site 383372009018 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 383372009019 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 383372009020 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 383372009021 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 383372009022 ATP-grasp domain; Region: ATP-grasp_4; cl03087 383372009023 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 383372009024 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 383372009025 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 383372009026 active site 383372009027 substrate binding site [chemical binding]; other site 383372009028 cosubstrate binding site; other site 383372009029 catalytic site [active] 383372009030 Response regulator receiver domain; Region: Response_reg; pfam00072 383372009031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372009032 active site 383372009033 phosphorylation site [posttranslational modification] 383372009034 intermolecular recognition site; other site 383372009035 dimerization interface [polypeptide binding]; other site 383372009036 GAF domain; Region: GAF; cl15785 383372009037 GAF domain; Region: GAF; cl15785 383372009038 GAF domain; Region: GAF_2; pfam13185 383372009039 GAF domain; Region: GAF; cl15785 383372009040 PAS domain; Region: PAS_9; pfam13426 383372009041 cyclase homology domain; Region: CHD; cd07302 383372009042 nucleotidyl binding site; other site 383372009043 metal binding site [ion binding]; metal-binding site 383372009044 dimer interface [polypeptide binding]; other site 383372009045 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 383372009046 active site 383372009047 dimer interfaces [polypeptide binding]; other site 383372009048 catalytic residues [active] 383372009049 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 383372009050 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 383372009051 metal binding site [ion binding]; metal-binding site 383372009052 dimer interface [polypeptide binding]; other site 383372009053 cyanophycin synthetase; Provisional; Region: PRK14016 383372009054 HerA helicase [Replication, recombination, and repair]; Region: COG0433 383372009055 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 383372009056 Domain of unknown function DUF87; Region: DUF87; pfam01935 383372009057 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 383372009058 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 383372009059 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 383372009060 protein binding site [polypeptide binding]; other site 383372009061 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 383372009062 threonine synthase; Reviewed; Region: PRK06721 383372009063 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 383372009064 homodimer interface [polypeptide binding]; other site 383372009065 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372009066 catalytic residue [active] 383372009067 aspartate kinase; Provisional; Region: PRK06291 383372009068 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 383372009069 nucleotide binding site [chemical binding]; other site 383372009070 substrate binding site [chemical binding]; other site 383372009071 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 383372009072 dimer interface [polypeptide binding]; other site 383372009073 putative threonine allosteric regulatory site; other site 383372009074 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 383372009075 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 383372009076 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372009077 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 383372009078 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 383372009079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372009080 S-adenosylmethionine binding site [chemical binding]; other site 383372009081 integral membrane protein MviN; Region: mviN; TIGR01695 383372009082 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 383372009083 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 383372009084 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 383372009085 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 383372009086 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 383372009087 active site 383372009088 catalytic tetrad [active] 383372009089 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 383372009090 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 383372009091 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372009092 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372009093 binding surface 383372009094 Tetratricopeptide repeat; Region: TPR_16; pfam13432 383372009095 TPR motif; other site 383372009096 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 383372009097 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372009098 active site 383372009099 phosphorylation site [posttranslational modification] 383372009100 intermolecular recognition site; other site 383372009101 dimerization interface [polypeptide binding]; other site 383372009102 CheB methylesterase; Region: CheB_methylest; pfam01339 383372009103 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 383372009104 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 383372009105 Response regulator receiver domain; Region: Response_reg; pfam00072 383372009106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372009107 active site 383372009108 phosphorylation site [posttranslational modification] 383372009109 intermolecular recognition site; other site 383372009110 dimerization interface [polypeptide binding]; other site 383372009111 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 383372009112 putative binding surface; other site 383372009113 active site 383372009114 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372009115 ATP binding site [chemical binding]; other site 383372009116 Mg2+ binding site [ion binding]; other site 383372009117 G-X-G motif; other site 383372009118 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 383372009119 Response regulator receiver domain; Region: Response_reg; pfam00072 383372009120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372009121 active site 383372009122 phosphorylation site [posttranslational modification] 383372009123 intermolecular recognition site; other site 383372009124 dimerization interface [polypeptide binding]; other site 383372009125 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 383372009126 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 383372009127 dimerization interface [polypeptide binding]; other site 383372009128 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 383372009129 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 383372009130 dimer interface [polypeptide binding]; other site 383372009131 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 383372009132 putative CheW interface [polypeptide binding]; other site 383372009133 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 383372009134 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 383372009135 ATP-grasp domain; Region: ATP-grasp_4; cl03087 383372009136 CoA-ligase; Region: Ligase_CoA; cl02894 383372009137 PspC domain; Region: PspC; cl00864 383372009138 putative acyltransferase; Provisional; Region: PRK05790 383372009139 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 383372009140 dimer interface [polypeptide binding]; other site 383372009141 active site 383372009142 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372009143 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 383372009144 structural tetrad; other site 383372009145 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 383372009146 CHAT domain; Region: CHAT; pfam12770 383372009147 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 383372009148 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 383372009149 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 383372009150 motif II; other site 383372009151 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 383372009152 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 383372009153 Ligand binding site; other site 383372009154 Putative Catalytic site; other site 383372009155 DXD motif; other site 383372009156 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 383372009157 FixH; Region: FixH; cl01254 383372009158 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 383372009159 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372009160 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 383372009161 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 383372009162 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 383372009163 active site 383372009164 catalytic tetrad [active] 383372009165 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 383372009166 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 383372009167 NADP-binding site; other site 383372009168 homotetramer interface [polypeptide binding]; other site 383372009169 substrate binding site [chemical binding]; other site 383372009170 homodimer interface [polypeptide binding]; other site 383372009171 active site 383372009172 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 383372009173 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 383372009174 inhibitor-cofactor binding pocket; inhibition site 383372009175 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372009176 catalytic residue [active] 383372009177 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 383372009178 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372009179 binding surface 383372009180 TPR motif; other site 383372009181 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372009182 binding surface 383372009183 TPR motif; other site 383372009184 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372009185 binding surface 383372009186 TPR motif; other site 383372009187 Tetratricopeptide repeat; Region: TPR_12; pfam13424 383372009188 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372009189 TPR motif; other site 383372009190 binding surface 383372009191 TPR repeat; Region: TPR_11; pfam13414 383372009192 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372009193 binding surface 383372009194 TPR motif; other site 383372009195 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372009196 binding surface 383372009197 TPR motif; other site 383372009198 Response regulator receiver domain; Region: Response_reg; pfam00072 383372009199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372009200 active site 383372009201 phosphorylation site [posttranslational modification] 383372009202 intermolecular recognition site; other site 383372009203 dimerization interface [polypeptide binding]; other site 383372009204 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 383372009205 metal binding site [ion binding]; metal-binding site 383372009206 active site 383372009207 I-site; other site 383372009208 Response regulator receiver domain; Region: Response_reg; pfam00072 383372009209 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 383372009210 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 383372009211 substrate binding site [chemical binding]; other site 383372009212 ATP binding site [chemical binding]; other site 383372009213 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 383372009214 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242 383372009215 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 383372009216 putative NAD(P) binding site [chemical binding]; other site 383372009217 catalytic Zn binding site [ion binding]; other site 383372009218 structural Zn binding site [ion binding]; other site 383372009219 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 383372009220 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 383372009221 putative active site [active] 383372009222 substrate binding site [chemical binding]; other site 383372009223 putative cosubstrate binding site; other site 383372009224 catalytic site [active] 383372009225 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 383372009226 substrate binding site [chemical binding]; other site 383372009227 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 383372009228 active site 383372009229 NTP binding site [chemical binding]; other site 383372009230 metal binding triad [ion binding]; metal-binding site 383372009231 antibiotic binding site [chemical binding]; other site 383372009232 HEPN domain; Region: HEPN; cl00824 383372009233 Haemolytic domain; Region: Haemolytic; cl00506 383372009234 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 383372009235 MPT binding site; other site 383372009236 trimer interface [polypeptide binding]; other site 383372009237 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 383372009238 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 383372009239 G1 box; other site 383372009240 GTP/Mg2+ binding site [chemical binding]; other site 383372009241 G2 box; other site 383372009242 Switch I region; other site 383372009243 G3 box; other site 383372009244 Switch II region; other site 383372009245 G4 box; other site 383372009246 G5 box; other site 383372009247 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 383372009248 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 383372009249 heme-binding site [chemical binding]; other site 383372009250 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 383372009251 CAAX protease self-immunity; Region: Abi; cl00558 383372009252 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14338 383372009253 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 383372009254 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 383372009255 FeS/SAM binding site; other site 383372009256 TRAM domain; Region: TRAM; cl01282 383372009257 CAAX protease self-immunity; Region: Abi; cl00558 383372009258 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372009259 TPR repeat; Region: TPR_11; pfam13414 383372009260 binding surface 383372009261 TPR motif; other site 383372009262 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 383372009263 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372009264 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 383372009265 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 383372009266 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 383372009267 ATP binding site [chemical binding]; other site 383372009268 Walker A motif; other site 383372009269 hexamer interface [polypeptide binding]; other site 383372009270 Walker B motif; other site 383372009271 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 383372009272 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 383372009273 active site 383372009274 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 383372009275 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 383372009276 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 383372009277 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 383372009278 DDE superfamily endonuclease; Region: DDE_5; cl02413 383372009279 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 383372009280 ATP cone domain; Region: ATP-cone; pfam03477 383372009281 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 383372009282 Restriction endonuclease; Region: Mrr_cat; cl00516 383372009283 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 383372009284 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 383372009285 NAD(P) binding site [chemical binding]; other site 383372009286 homotetramer interface [polypeptide binding]; other site 383372009287 homodimer interface [polypeptide binding]; other site 383372009288 active site 383372009289 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 383372009290 putative RNA binding site [nucleotide binding]; other site 383372009291 Phosphopantetheine attachment site; Region: PP-binding; cl09936 383372009292 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 383372009293 Topoisomerase II-associated protein PAT1; Region: PAT1; pfam09770 383372009294 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 383372009295 Ribosomal RNA methyltransferase (FmrO); Region: FmrO; pfam07091 383372009296 Peptidase family M48; Region: Peptidase_M48; cl12018 383372009297 Histidine kinase; Region: HisKA_3; pfam07730 383372009298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372009299 ATP binding site [chemical binding]; other site 383372009300 Mg2+ binding site [ion binding]; other site 383372009301 G-X-G motif; other site 383372009302 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 383372009303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372009304 active site 383372009305 phosphorylation site [posttranslational modification] 383372009306 intermolecular recognition site; other site 383372009307 dimerization interface [polypeptide binding]; other site 383372009308 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 383372009309 DNA binding residues [nucleotide binding] 383372009310 dimerization interface [polypeptide binding]; other site 383372009311 Domain of unknown function (DUF897); Region: DUF897; cl01312 383372009312 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372009313 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 383372009314 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 383372009315 Queuine tRNA-ribosyltransferase; Region: TGT; pfam01702 383372009316 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 383372009317 active site 383372009318 dimer interface [polypeptide binding]; other site 383372009319 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 383372009320 competence damage-inducible protein A; Provisional; Region: PRK01215 383372009321 putative MPT binding site; other site 383372009322 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 383372009323 MOFRL family; Region: MOFRL; pfam05161 383372009324 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 383372009325 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 383372009326 active site 383372009327 Zn binding site [ion binding]; other site 383372009328 TPR repeat; Region: TPR_11; pfam13414 383372009329 TPR repeat; Region: TPR_11; pfam13414 383372009330 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372009331 binding surface 383372009332 TPR motif; other site 383372009333 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 383372009334 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 383372009335 metal ion-dependent adhesion site (MIDAS); other site 383372009336 Protein kinase domain; Region: Pkinase; pfam00069 383372009337 Catalytic domain of Protein Kinases; Region: PKc; cd00180 383372009338 active site 383372009339 ATP binding site [chemical binding]; other site 383372009340 substrate binding site [chemical binding]; other site 383372009341 activation loop (A-loop); other site 383372009342 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 383372009343 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 383372009344 phosphopeptide binding site; other site 383372009345 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 383372009346 conserved cys residue [active] 383372009347 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 383372009348 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 383372009349 substrate binding pocket [chemical binding]; other site 383372009350 membrane-bound complex binding site; other site 383372009351 hinge residues; other site 383372009352 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 383372009353 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 383372009354 Walker A motif; other site 383372009355 ATP binding site [chemical binding]; other site 383372009356 Walker B motif; other site 383372009357 Peptidase family M41; Region: Peptidase_M41; pfam01434 383372009358 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 383372009359 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 383372009360 NADP-binding site; other site 383372009361 homotetramer interface [polypeptide binding]; other site 383372009362 substrate binding site [chemical binding]; other site 383372009363 homodimer interface [polypeptide binding]; other site 383372009364 active site 383372009365 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 383372009366 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 383372009367 active site 383372009368 Substrate binding site; other site 383372009369 Mg++ binding site; other site 383372009370 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 383372009371 putative trimer interface [polypeptide binding]; other site 383372009372 putative CoA binding site [chemical binding]; other site 383372009373 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 383372009374 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372009375 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 383372009376 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 383372009377 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 383372009378 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 383372009379 Ferritin-like domain; Region: Ferritin; pfam00210 383372009380 ferroxidase diiron center [ion binding]; other site 383372009381 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732 383372009382 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl14784 383372009383 CRISPR-associated protein; Region: TIGR03986 383372009384 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 383372009385 CRISPR-associated protein; Region: TIGR03986 383372009386 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 383372009387 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 383372009388 CRISPR-associated protein; Region: TIGR03986 383372009389 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 383372009390 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 383372009391 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 383372009392 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 383372009393 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 383372009394 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl09839 383372009395 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 383372009396 DNA binding residues [nucleotide binding] 383372009397 AAA domain; Region: AAA_33; pfam13671 383372009398 CRISPR/Cas system-associated protein Csx3; Region: Csx3_III-U; cl09837 383372009399 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 383372009400 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 383372009401 CRISPR-associated protein Cas5, subtype I-B/TNEAP; Region: cas_Cas5t; TIGR01895 383372009402 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693 383372009403 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 383372009404 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372009405 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 383372009406 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 383372009407 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 383372009408 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 383372009409 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 383372009410 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 383372009411 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 383372009412 FeS/SAM binding site; other site 383372009413 HemN C-terminal domain; Region: HemN_C; pfam06969 383372009414 CHASE4 domain; Region: CHASE4; cl01308 383372009415 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 383372009416 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 383372009417 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 383372009418 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372009419 dimer interface [polypeptide binding]; other site 383372009420 phosphorylation site [posttranslational modification] 383372009421 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372009422 ATP binding site [chemical binding]; other site 383372009423 Mg2+ binding site [ion binding]; other site 383372009424 G-X-G motif; other site 383372009425 Response regulator receiver domain; Region: Response_reg; pfam00072 383372009426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372009427 active site 383372009428 phosphorylation site [posttranslational modification] 383372009429 intermolecular recognition site; other site 383372009430 dimerization interface [polypeptide binding]; other site 383372009431 Response regulator receiver domain; Region: Response_reg; pfam00072 383372009432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372009433 active site 383372009434 phosphorylation site [posttranslational modification] 383372009435 intermolecular recognition site; other site 383372009436 dimerization interface [polypeptide binding]; other site 383372009437 Response regulator receiver domain; Region: Response_reg; pfam00072 383372009438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372009439 active site 383372009440 phosphorylation site [posttranslational modification] 383372009441 intermolecular recognition site; other site 383372009442 dimerization interface [polypeptide binding]; other site 383372009443 Response regulator receiver domain; Region: Response_reg; pfam00072 383372009444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372009445 active site 383372009446 phosphorylation site [posttranslational modification] 383372009447 intermolecular recognition site; other site 383372009448 dimerization interface [polypeptide binding]; other site 383372009449 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 383372009450 PAS domain; Region: PAS_9; pfam13426 383372009451 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 383372009452 PAS fold; Region: PAS_3; pfam08447 383372009453 putative active site [active] 383372009454 heme pocket [chemical binding]; other site 383372009455 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 383372009456 metal binding site [ion binding]; metal-binding site 383372009457 active site 383372009458 I-site; other site 383372009459 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 383372009460 40S ribosomal protein S2; Provisional; Region: PTZ00070 383372009461 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 383372009462 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 383372009463 active site 383372009464 dimer interface [polypeptide binding]; other site 383372009465 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 383372009466 active site 383372009467 Substrate binding site; other site 383372009468 Mg++ binding site; other site 383372009469 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 383372009470 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 383372009471 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 383372009472 dimer interaction site [polypeptide binding]; other site 383372009473 substrate-binding tunnel; other site 383372009474 active site 383372009475 catalytic site [active] 383372009476 substrate binding site [chemical binding]; other site 383372009477 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 383372009478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 383372009479 putative substrate translocation pore; other site 383372009480 Major Facilitator Superfamily; Region: MFS_1; pfam07690 383372009481 Protein of unknown function DUF45; Region: DUF45; cl00636 383372009482 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 383372009483 active site 383372009484 catalytic residues [active] 383372009485 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 383372009486 Helix-turn-helix domains; Region: HTH; cl00088 383372009487 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 383372009488 FeoA domain; Region: FeoA; cl00838 383372009489 UGMP family protein; Validated; Region: PRK09604 383372009490 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 383372009491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372009492 S-adenosylmethionine binding site [chemical binding]; other site 383372009493 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 383372009494 Protein export membrane protein; Region: SecD_SecF; cl14618 383372009495 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 383372009496 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 383372009497 Protein export membrane protein; Region: SecD_SecF; cl14618 383372009498 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 383372009499 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 383372009500 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 383372009501 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 383372009502 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 383372009503 ATP binding site [chemical binding]; other site 383372009504 putative Mg++ binding site [ion binding]; other site 383372009505 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 383372009506 nucleotide binding region [chemical binding]; other site 383372009507 ATP-binding site [chemical binding]; other site 383372009508 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 383372009509 active site 383372009510 Zn binding site [ion binding]; other site 383372009511 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 383372009512 catalytic core [active] 383372009513 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 383372009514 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 383372009515 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 383372009516 minor groove reading motif; other site 383372009517 helix-hairpin-helix signature motif; other site 383372009518 active site 383372009519 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 383372009520 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 383372009521 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 383372009522 AMP-binding enzyme; Region: AMP-binding; cl15778 383372009523 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 383372009524 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 383372009525 catalytic residues [active] 383372009526 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 383372009527 catalytic residues [active] 383372009528 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 383372009529 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 383372009530 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 383372009531 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 383372009532 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372009533 S-adenosylmethionine binding site [chemical binding]; other site 383372009534 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 383372009535 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 383372009536 Catalytic domain of Protein Kinases; Region: PKc; cd00180 383372009537 active site 383372009538 ATP binding site [chemical binding]; other site 383372009539 substrate binding site [chemical binding]; other site 383372009540 activation loop (A-loop); other site 383372009541 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 383372009542 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 383372009543 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 383372009544 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372009545 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 383372009546 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 383372009547 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 383372009548 Fibronectin type III-like domain; Region: Fn3-like; cl15273 383372009549 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 383372009550 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 383372009551 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 383372009552 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 383372009553 heterotetramer interface [polypeptide binding]; other site 383372009554 active site pocket [active] 383372009555 cleavage site 383372009556 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 383372009557 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 383372009558 ANP binding site [chemical binding]; other site 383372009559 Substrate Binding Site II [chemical binding]; other site 383372009560 Substrate Binding Site I [chemical binding]; other site 383372009561 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 383372009562 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 383372009563 ATP-grasp domain; Region: ATP-grasp_4; cl03087 383372009564 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 383372009565 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 383372009566 ATP-grasp domain; Region: ATP-grasp_4; cl03087 383372009567 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 383372009568 IMP binding site; other site 383372009569 dimer interface [polypeptide binding]; other site 383372009570 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 383372009571 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 383372009572 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 383372009573 catalytic site [active] 383372009574 subunit interface [polypeptide binding]; other site 383372009575 bifunctional argininosuccinate lyase/N-acetylglutamate synthase; Provisional; Region: PRK12308 383372009576 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 383372009577 Coenzyme A binding pocket [chemical binding]; other site 383372009578 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 383372009579 nucleotide binding site [chemical binding]; other site 383372009580 N-acetyl-L-glutamate binding site [chemical binding]; other site 383372009581 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 383372009582 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372009583 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 383372009584 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 383372009585 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 383372009586 homodimer interface [polypeptide binding]; other site 383372009587 substrate-cofactor binding pocket; other site 383372009588 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372009589 catalytic residue [active] 383372009590 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 383372009591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 383372009592 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 383372009593 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 383372009594 active site 383372009595 (T/H)XGH motif; other site 383372009596 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 383372009597 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 383372009598 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 383372009599 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372009600 putative active site [active] 383372009601 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372009602 putative active site [active] 383372009603 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372009604 putative active site [active] 383372009605 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372009606 putative active site [active] 383372009607 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 383372009608 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372009609 Family description; Region: UvrD_C_2; cl15862 383372009610 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 383372009611 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 383372009612 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 383372009613 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 383372009614 Catalytic domain of Protein Kinases; Region: PKc; cd00180 383372009615 active site 383372009616 ATP binding site [chemical binding]; other site 383372009617 substrate binding site [chemical binding]; other site 383372009618 activation loop (A-loop); other site 383372009619 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 383372009620 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 383372009621 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 383372009622 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 383372009623 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 383372009624 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 383372009625 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 383372009626 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 383372009627 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 383372009628 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 383372009629 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 383372009630 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 383372009631 NADH dehydrogenase; Region: NADHdh; cl00469 383372009632 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 383372009633 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 383372009634 catalytic loop [active] 383372009635 iron binding site [ion binding]; other site 383372009636 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 383372009637 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 383372009638 molybdopterin cofactor binding site; other site 383372009639 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 383372009640 molybdopterin cofactor binding site; other site 383372009641 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372009642 putative active site [active] 383372009643 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 383372009644 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 383372009645 SLBB domain; Region: SLBB; pfam10531 383372009646 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 383372009647 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 383372009648 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 383372009649 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372009650 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 383372009651 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 383372009652 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372009653 putative active site [active] 383372009654 adenylate kinase; Reviewed; Region: adk; PRK00279 383372009655 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 383372009656 AMP-binding site [chemical binding]; other site 383372009657 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 383372009658 haloacid dehalogenase superfamily protein; Provisional; Region: PRK14562 383372009659 Translin family; Region: Translin; cl00957 383372009660 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 383372009661 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 383372009662 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 383372009663 Walker A/P-loop; other site 383372009664 ATP binding site [chemical binding]; other site 383372009665 Q-loop/lid; other site 383372009666 ABC transporter signature motif; other site 383372009667 Walker B; other site 383372009668 D-loop; other site 383372009669 H-loop/switch region; other site 383372009670 Deoxyhypusine synthase; Region: DS; cl00826 383372009671 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 383372009672 Clp protease; Region: CLP_protease; pfam00574 383372009673 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 383372009674 oligomer interface [polypeptide binding]; other site 383372009675 active site residues [active] 383372009676 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 383372009677 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 383372009678 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 383372009679 NAD binding site [chemical binding]; other site 383372009680 homotetramer interface [polypeptide binding]; other site 383372009681 homodimer interface [polypeptide binding]; other site 383372009682 substrate binding site [chemical binding]; other site 383372009683 active site 383372009684 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 383372009685 Septum formation topological specificity factor MinE; Region: MinE; cl00538 383372009686 septum site-determining protein MinD; Region: minD_bact; TIGR01968 383372009687 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 383372009688 Switch I; other site 383372009689 Switch II; other site 383372009690 septum formation inhibitor; Reviewed; Region: minC; PRK00513 383372009691 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 383372009692 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 383372009693 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 383372009694 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372009695 homodimer interface [polypeptide binding]; other site 383372009696 catalytic residue [active] 383372009697 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 383372009698 Flavoprotein; Region: Flavoprotein; cl08021 383372009699 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 383372009700 HEAT repeats; Region: HEAT_2; pfam13646 383372009701 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 383372009702 YceG-like family; Region: YceG; pfam02618 383372009703 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 383372009704 dimerization interface [polypeptide binding]; other site 383372009705 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 383372009706 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 383372009707 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 383372009708 shikimate binding site; other site 383372009709 NAD(P) binding site [chemical binding]; other site 383372009710 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 383372009711 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 383372009712 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 383372009713 putative active site [active] 383372009714 catalytic triad [active] 383372009715 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 383372009716 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 383372009717 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 383372009718 dimerization interface [polypeptide binding]; other site 383372009719 GAF domain; Region: GAF; cl15785 383372009720 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 383372009721 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 383372009722 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372009723 dimer interface [polypeptide binding]; other site 383372009724 phosphorylation site [posttranslational modification] 383372009725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372009726 ATP binding site [chemical binding]; other site 383372009727 Mg2+ binding site [ion binding]; other site 383372009728 G-X-G motif; other site 383372009729 GAF domain; Region: GAF; cl15785 383372009730 GAF domain; Region: GAF_2; pfam13185 383372009731 GAF domain; Region: GAF_2; pfam13185 383372009732 GAF domain; Region: GAF; cl15785 383372009733 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 383372009734 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 383372009735 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372009736 dimer interface [polypeptide binding]; other site 383372009737 phosphorylation site [posttranslational modification] 383372009738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372009739 ATP binding site [chemical binding]; other site 383372009740 Mg2+ binding site [ion binding]; other site 383372009741 G-X-G motif; other site 383372009742 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 383372009743 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372009744 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 383372009745 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372009746 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 383372009747 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 383372009748 GAF domain; Region: GAF; cl15785 383372009749 GAF domain; Region: GAF_2; pfam13185 383372009750 GAF domain; Region: GAF; cl15785 383372009751 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 383372009752 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372009753 dimer interface [polypeptide binding]; other site 383372009754 phosphorylation site [posttranslational modification] 383372009755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372009756 ATP binding site [chemical binding]; other site 383372009757 Mg2+ binding site [ion binding]; other site 383372009758 G-X-G motif; other site 383372009759 Predicted permeases [General function prediction only]; Region: RarD; COG2962 383372009760 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 383372009761 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 383372009762 CcmE; Region: CcmE; cl00994 383372009763 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 383372009764 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 383372009765 ligand binding site [chemical binding]; other site 383372009766 flexible hinge region; other site 383372009767 Helix-turn-helix domains; Region: HTH; cl00088 383372009768 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 383372009769 FAD binding domain; Region: FAD_binding_4; pfam01565 383372009770 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 383372009771 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 383372009772 FAD binding domain; Region: FAD_binding_4; pfam01565 383372009773 Cytochrome c; Region: Cytochrom_C; cl11414 383372009774 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 383372009775 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 383372009776 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 383372009777 NAD binding site [chemical binding]; other site 383372009778 substrate binding site [chemical binding]; other site 383372009779 homodimer interface [polypeptide binding]; other site 383372009780 active site 383372009781 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 383372009782 amidase catalytic site [active] 383372009783 Zn binding residues [ion binding]; other site 383372009784 substrate binding site [chemical binding]; other site 383372009785 PA14 domain; Region: PA14; cl08459 383372009786 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 383372009787 Competence protein; Region: Competence; cl00471 383372009788 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 383372009789 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 383372009790 dimerization interface [polypeptide binding]; other site 383372009791 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 383372009792 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 383372009793 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 383372009794 dimer interface [polypeptide binding]; other site 383372009795 putative CheW interface [polypeptide binding]; other site 383372009796 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372009797 putative active site [active] 383372009798 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 383372009799 Peptidase M30; Region: Peptidase_M30; pfam10460 383372009800 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 383372009801 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 383372009802 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 383372009803 Found in ATP-dependent protease La (LON); Region: LON; smart00464 383372009804 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 383372009805 Walker A motif; other site 383372009806 ATP binding site [chemical binding]; other site 383372009807 Walker B motif; other site 383372009808 arginine finger; other site 383372009809 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 383372009810 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 383372009811 Phosphotransferase enzyme family; Region: APH; pfam01636 383372009812 formyl-coenzyme A transferase; Provisional; Region: PRK05398 383372009813 CoA-transferase family III; Region: CoA_transf_3; pfam02515 383372009814 SEC-C motif; Region: SEC-C; pfam02810 383372009815 HicB family; Region: HicB; pfam05534 383372009816 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 383372009817 active site 383372009818 metal binding site [ion binding]; metal-binding site 383372009819 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 383372009820 catalytic core [active] 383372009821 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 383372009822 RDD family; Region: RDD; cl00746 383372009823 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 383372009824 ATP-dependent DNA ligase; Validated; Region: PRK09247 383372009825 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 383372009826 active site 383372009827 DNA binding site [nucleotide binding] 383372009828 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 383372009829 DNA binding site [nucleotide binding] 383372009830 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 383372009831 L-rhamnulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 383372009832 N- and C-terminal domain interface [polypeptide binding]; other site 383372009833 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 383372009834 active site 383372009835 catalytic site [active] 383372009836 metal binding site [ion binding]; metal-binding site 383372009837 ATP binding site [chemical binding]; other site 383372009838 carbohydrate binding site [chemical binding]; other site 383372009839 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase; Region: RhaD_aldol-ADH; TIGR02632 383372009840 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 383372009841 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372009842 NAD(P) binding site [chemical binding]; other site 383372009843 active site 383372009844 L-rhamnose isomerase; Provisional; Region: PRK01076 383372009845 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 383372009846 Domain of unknown function (DUF718); Region: DUF718; cl01281 383372009847 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 383372009848 Helix-turn-helix domains; Region: HTH; cl00088 383372009849 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 383372009850 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372009851 putative active site [active] 383372009852 M20 Peptidase acetylornithine deacetylase/acetyl-lysine deacetylase; Region: M20_ArgE_LysK; cd05653 383372009853 acetyl-lysine deacetylase; Validated; Region: PRK00466 383372009854 metal binding site [ion binding]; metal-binding site 383372009855 putative dimer interface [polypeptide binding]; other site 383372009856 acetylornithine aminotransferase; Provisional; Region: PRK02627 383372009857 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 383372009858 inhibitor-cofactor binding pocket; inhibition site 383372009859 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372009860 catalytic residue [active] 383372009861 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 383372009862 drug efflux system protein MdtG; Provisional; Region: PRK09874 383372009863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 383372009864 putative substrate translocation pore; other site 383372009865 Transposase domain (DUF772); Region: DUF772; cl15789 383372009866 AAK_NAGK-UC: N-Acetyl-L-glutamate kinase - uncharacterized (NAGK-UC). This domain is similar to Escherichia coli and Pseudomonas aeruginosa NAGKs which catalyze the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the...; Region: AAK_NAGK-UC; cd04251 383372009867 putative N-acetyl-L-glutamate binding site [chemical binding]; other site 383372009868 putative nucleotide binding site [chemical binding]; other site 383372009869 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 383372009870 active site 383372009871 metal binding site [ion binding]; metal-binding site 383372009872 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 383372009873 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372009874 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 383372009875 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 383372009876 ATP-grasp domain; Region: ATP-grasp_4; cl03087 383372009877 lysine biosynthesis protein LysW; Region: lysW; TIGR01206 383372009878 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 383372009879 tartrate dehydrogenase; Provisional; Region: PRK08194 383372009880 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 383372009881 substrate binding site [chemical binding]; other site 383372009882 cystathionine gamma-synthase; Provisional; Region: PRK07811 383372009883 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 383372009884 homodimer interface [polypeptide binding]; other site 383372009885 substrate-cofactor binding pocket; other site 383372009886 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372009887 catalytic residue [active] 383372009888 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 383372009889 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 383372009890 substrate binding site [chemical binding]; other site 383372009891 ligand binding site [chemical binding]; other site 383372009892 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 383372009893 active site 383372009894 catalytic residues [active] 383372009895 metal binding site [ion binding]; metal-binding site 383372009896 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 383372009897 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 383372009898 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 383372009899 P loop; other site 383372009900 GTP binding site [chemical binding]; other site 383372009901 lysine biosynthesis protein LysW; Region: lysW; TIGR01206 383372009902 glutamine synthetase, type I; Region: GlnA; TIGR00653 383372009903 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 383372009904 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 383372009905 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 383372009906 Cytochrome oxidase complex assembly protein 1; Region: Coa1; cl14904 383372009907 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 383372009908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 383372009909 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 383372009910 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 383372009911 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372009912 putative active site [active] 383372009913 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 383372009914 putative catalytic residue [active] 383372009915 phytoene desaturase; Region: crtI_fam; TIGR02734 383372009916 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372009917 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 383372009918 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 383372009919 activation loop (A-loop); other site 383372009920 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 383372009921 structural tetrad; other site 383372009922 PQQ-like domain; Region: PQQ_2; pfam13360 383372009923 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 383372009924 structural tetrad; other site 383372009925 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 383372009926 Isochorismatase family; Region: Isochorismatase; pfam00857 383372009927 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015 383372009928 substrate binding site [chemical binding]; other site 383372009929 catalytic triad [active] 383372009930 domain interfaces; other site 383372009931 conserved cis-peptide bond; other site 383372009932 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 383372009933 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 383372009934 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 383372009935 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 383372009936 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 383372009937 active site 383372009938 catalytic residues [active] 383372009939 metal binding site [ion binding]; metal-binding site 383372009940 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 383372009941 CoA-transferase family III; Region: CoA_transf_3; pfam02515 383372009942 Transcriptional regulators [Transcription]; Region: GntR; COG1802 383372009943 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 383372009944 DNA-binding site [nucleotide binding]; DNA binding site 383372009945 FCD domain; Region: FCD; cl11656 383372009946 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 383372009947 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 383372009948 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 383372009949 Walker A/P-loop; other site 383372009950 ATP binding site [chemical binding]; other site 383372009951 Q-loop/lid; other site 383372009952 ABC transporter signature motif; other site 383372009953 Walker B; other site 383372009954 D-loop; other site 383372009955 H-loop/switch region; other site 383372009956 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 383372009957 TM-ABC transporter signature motif; other site 383372009958 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 383372009959 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 383372009960 Walker A/P-loop; other site 383372009961 ATP binding site [chemical binding]; other site 383372009962 Q-loop/lid; other site 383372009963 ABC transporter signature motif; other site 383372009964 Walker B; other site 383372009965 D-loop; other site 383372009966 H-loop/switch region; other site 383372009967 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 383372009968 TM-ABC transporter signature motif; other site 383372009969 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 383372009970 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 383372009971 ligand binding site [chemical binding]; other site 383372009972 Cupin domain; Region: Cupin_2; cl09118 383372009973 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 383372009974 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 383372009975 NAD(P) binding site [chemical binding]; other site 383372009976 catalytic residues [active] 383372009977 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_4; cd07582 383372009978 Predicted amidohydrolase [General function prediction only]; Region: COG0388 383372009979 putative active site [active] 383372009980 catalytic triad [active] 383372009981 putative dimer interface [polypeptide binding]; other site 383372009982 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 383372009983 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 383372009984 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 383372009985 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 383372009986 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 383372009987 DNA-binding site [nucleotide binding]; DNA binding site 383372009988 UTRA domain; Region: UTRA; cl01230 383372009989 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 383372009990 Domain of unknown function (DUF296); Region: DUF296; cl00720 383372009991 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 383372009992 catalytic triad [active] 383372009993 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 383372009994 active site 383372009995 catalytic residues [active] 383372009996 metal binding site [ion binding]; metal-binding site 383372009997 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 383372009998 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 383372009999 substrate binding site [chemical binding]; other site 383372010000 ligand binding site [chemical binding]; other site 383372010001 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 383372010002 substrate binding site [chemical binding]; other site 383372010003 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 383372010004 CoA-transferase family III; Region: CoA_transf_3; pfam02515 383372010005 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 383372010006 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 383372010007 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 383372010008 active site 383372010009 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 383372010010 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 383372010011 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 383372010012 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 383372010013 Catalytic site [active] 383372010014 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 383372010015 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 383372010016 phosphopeptide binding site; other site 383372010017 GTP-binding protein Der; Reviewed; Region: PRK00093 383372010018 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 383372010019 G1 box; other site 383372010020 GTP/Mg2+ binding site [chemical binding]; other site 383372010021 Switch I region; other site 383372010022 G2 box; other site 383372010023 Switch II region; other site 383372010024 G3 box; other site 383372010025 G4 box; other site 383372010026 G5 box; other site 383372010027 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 383372010028 G1 box; other site 383372010029 GTP/Mg2+ binding site [chemical binding]; other site 383372010030 Switch I region; other site 383372010031 G2 box; other site 383372010032 G3 box; other site 383372010033 Switch II region; other site 383372010034 G4 box; other site 383372010035 G5 box; other site 383372010036 GAF domain; Region: GAF; cl15785 383372010037 GAF domain; Region: GAF_2; pfam13185 383372010038 GAF domain; Region: GAF; cl15785 383372010039 GAF domain; Region: GAF_2; pfam13185 383372010040 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 383372010041 Zn2+ binding site [ion binding]; other site 383372010042 Mg2+ binding site [ion binding]; other site 383372010043 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 383372010044 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 383372010045 Protein of unknown function (DUF512); Region: DUF512; pfam04459 383372010046 malate dehydrogenase; Provisional; Region: PRK13529 383372010047 Malic enzyme, N-terminal domain; Region: malic; pfam00390 383372010048 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 383372010049 NAD(P) binding site [chemical binding]; other site 383372010050 excinuclease ABC subunit B; Provisional; Region: PRK05298 383372010051 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 383372010052 nucleotide binding region [chemical binding]; other site 383372010053 ATP-binding site [chemical binding]; other site 383372010054 Ultra-violet resistance protein B; Region: UvrB; pfam12344 383372010055 MutS domain I; Region: MutS_I; pfam01624 383372010056 MutS domain II; Region: MutS_II; pfam05188 383372010057 MutS domain III; Region: MutS_III; pfam05192 383372010058 MutS family domain IV; Region: MutS_IV; pfam05190 383372010059 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 383372010060 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 383372010061 Walker A/P-loop; other site 383372010062 ATP binding site [chemical binding]; other site 383372010063 Q-loop/lid; other site 383372010064 ABC transporter signature motif; other site 383372010065 Walker B; other site 383372010066 D-loop; other site 383372010067 H-loop/switch region; other site 383372010068 Phospholipid methyltransferase; Region: PEMT; cl00763 383372010069 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 383372010070 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 383372010071 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 383372010072 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 383372010073 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 383372010074 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 383372010075 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 383372010076 protein binding site [polypeptide binding]; other site 383372010077 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 383372010078 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 383372010079 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 383372010080 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 383372010081 polyphosphate kinase; Provisional; Region: PRK05443 383372010082 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 383372010083 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 383372010084 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 383372010085 putative domain interface [polypeptide binding]; other site 383372010086 putative active site [active] 383372010087 catalytic site [active] 383372010088 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 383372010089 putative domain interface [polypeptide binding]; other site 383372010090 putative active site [active] 383372010091 catalytic site [active] 383372010092 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 383372010093 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 383372010094 trimer interface [polypeptide binding]; other site 383372010095 active site 383372010096 substrate binding site [chemical binding]; other site 383372010097 CoA binding site [chemical binding]; other site 383372010098 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 383372010099 active site 383372010100 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 383372010101 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 383372010102 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 383372010103 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 383372010104 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 383372010105 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 383372010106 Protein of unknown function DUF262; Region: DUF262; cl14890 383372010107 Uncharacterized conserved protein [Function unknown]; Region: COG4938 383372010108 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372010109 Walker A/P-loop; other site 383372010110 ATP binding site [chemical binding]; other site 383372010111 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 383372010112 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 383372010113 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 383372010114 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372010115 Walker A/P-loop; other site 383372010116 ATP binding site [chemical binding]; other site 383372010117 Q-loop/lid; other site 383372010118 ABC transporter signature motif; other site 383372010119 Walker B; other site 383372010120 D-loop; other site 383372010121 H-loop/switch region; other site 383372010122 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 383372010123 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 383372010124 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 383372010125 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 383372010126 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 383372010127 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 383372010128 Walker A/P-loop; other site 383372010129 ATP binding site [chemical binding]; other site 383372010130 Q-loop/lid; other site 383372010131 ABC transporter signature motif; other site 383372010132 Walker B; other site 383372010133 D-loop; other site 383372010134 H-loop/switch region; other site 383372010135 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 383372010136 Cupin domain; Region: Cupin_2; cl09118 383372010137 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 383372010138 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 383372010139 Subunit I/III interface [polypeptide binding]; other site 383372010140 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 383372010141 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 383372010142 D-pathway; other site 383372010143 Putative ubiquinol binding site [chemical binding]; other site 383372010144 Low-spin heme (heme b) binding site [chemical binding]; other site 383372010145 Putative water exit pathway; other site 383372010146 Binuclear center (heme o3/CuB) [ion binding]; other site 383372010147 K-pathway; other site 383372010148 Putative proton exit pathway; other site 383372010149 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 383372010150 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 383372010151 Cytochrome c; Region: Cytochrom_C; cl11414 383372010152 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 383372010153 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 383372010154 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 383372010155 Probable zinc-binding domain; Region: zf-trcl; pfam13451 383372010156 Predicted transcriptional regulators [Transcription]; Region: COG1725 383372010157 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 383372010158 DNA-binding site [nucleotide binding]; DNA binding site 383372010159 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 383372010160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372010161 dimer interface [polypeptide binding]; other site 383372010162 conserved gate region; other site 383372010163 putative PBP binding loops; other site 383372010164 ABC-ATPase subunit interface; other site 383372010165 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 383372010166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372010167 dimer interface [polypeptide binding]; other site 383372010168 conserved gate region; other site 383372010169 putative PBP binding loops; other site 383372010170 ABC-ATPase subunit interface; other site 383372010171 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 383372010172 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 383372010173 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 383372010174 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 383372010175 active site 383372010176 catalytic residues [active] 383372010177 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 383372010178 classical (c) SDRs; Region: SDR_c; cd05233 383372010179 NAD(P) binding site [chemical binding]; other site 383372010180 active site 383372010181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 383372010182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 383372010183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372010184 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 383372010185 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 383372010186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372010187 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 383372010188 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 383372010189 catalytic residues [active] 383372010190 Rdx family; Region: Rdx; cl01407 383372010191 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 383372010192 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 383372010193 TPP-binding site [chemical binding]; other site 383372010194 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 383372010195 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 383372010196 dimer interface [polypeptide binding]; other site 383372010197 PYR/PP interface [polypeptide binding]; other site 383372010198 TPP binding site [chemical binding]; other site 383372010199 substrate binding site [chemical binding]; other site 383372010200 2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed; Region: oorD; PRK09626 383372010201 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 383372010202 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 383372010203 FeS/SAM binding site; other site 383372010204 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 383372010205 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 383372010206 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 383372010207 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14461 383372010208 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 383372010209 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 383372010210 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 383372010211 catalytic residue [active] 383372010212 oligoendopeptidase F; Region: pepF; TIGR00181 383372010213 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 383372010214 active site 383372010215 Zn binding site [ion binding]; other site 383372010216 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 383372010217 putative active site [active] 383372010218 putative metal binding residues [ion binding]; other site 383372010219 signature motif; other site 383372010220 putative triphosphate binding site [ion binding]; other site 383372010221 CHAD domain; Region: CHAD; cl10506 383372010222 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 383372010223 16S/18S rRNA binding site [nucleotide binding]; other site 383372010224 S13e-L30e interaction site [polypeptide binding]; other site 383372010225 25S rRNA binding site [nucleotide binding]; other site 383372010226 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 383372010227 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 383372010228 RNase E interface [polypeptide binding]; other site 383372010229 trimer interface [polypeptide binding]; other site 383372010230 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 383372010231 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 383372010232 RNase E interface [polypeptide binding]; other site 383372010233 trimer interface [polypeptide binding]; other site 383372010234 active site 383372010235 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 383372010236 putative nucleic acid binding region [nucleotide binding]; other site 383372010237 G-X-X-G motif; other site 383372010238 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 383372010239 RNA binding site [nucleotide binding]; other site 383372010240 domain interface; other site 383372010241 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 383372010242 transmembrane helices; other site 383372010243 CAAX protease self-immunity; Region: Abi; cl00558 383372010244 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 383372010245 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 383372010246 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372010247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372010248 hypothetical protein; Provisional; Region: PRK05858 383372010249 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 383372010250 PYR/PP interface [polypeptide binding]; other site 383372010251 dimer interface [polypeptide binding]; other site 383372010252 TPP binding site [chemical binding]; other site 383372010253 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 383372010254 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 383372010255 TPP-binding site; other site 383372010256 dimer interface [polypeptide binding]; other site 383372010257 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 383372010258 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 383372010259 Ligand binding site [chemical binding]; other site 383372010260 Electron transfer flavoprotein domain; Region: ETF; pfam01012 383372010261 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 383372010262 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 383372010263 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 383372010264 oxidoreductase; Provisional; Region: PRK10015 383372010265 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 383372010266 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 383372010267 PAS fold; Region: PAS_4; pfam08448 383372010268 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 383372010269 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372010270 dimer interface [polypeptide binding]; other site 383372010271 phosphorylation site [posttranslational modification] 383372010272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372010273 ATP binding site [chemical binding]; other site 383372010274 Mg2+ binding site [ion binding]; other site 383372010275 G-X-G motif; other site 383372010276 Response regulator receiver domain; Region: Response_reg; pfam00072 383372010277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372010278 active site 383372010279 phosphorylation site [posttranslational modification] 383372010280 intermolecular recognition site; other site 383372010281 dimerization interface [polypeptide binding]; other site 383372010282 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 383372010283 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 383372010284 Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154 383372010285 Rab subfamily motif 1 (RabSF1); other site 383372010286 G1 box; other site 383372010287 GTP/Mg2+ binding site [chemical binding]; other site 383372010288 Rab subfamily motif 2 (RabSF2); other site 383372010289 Switch I region; other site 383372010290 G2 box; other site 383372010291 effector interaction site; other site 383372010292 GDI interaction site; other site 383372010293 Rab family motif 1 (RabF1); other site 383372010294 GEF interaction site [polypeptide binding]; other site 383372010295 Rab family motif 2 (RabF2); other site 383372010296 G3 box; other site 383372010297 Switch II region; other site 383372010298 Rab family motif 3 (RabF3); other site 383372010299 Rab family motif 4 (RabF4); other site 383372010300 Rab family motif 5 (RabF5); other site 383372010301 Rab subfamily motif 3 (RabSF3); other site 383372010302 G4 box; other site 383372010303 G5 box; other site 383372010304 Response regulator receiver domain; Region: Response_reg; pfam00072 383372010305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372010306 active site 383372010307 phosphorylation site [posttranslational modification] 383372010308 intermolecular recognition site; other site 383372010309 dimerization interface [polypeptide binding]; other site 383372010310 PAS domain S-box; Region: sensory_box; TIGR00229 383372010311 GAF domain; Region: GAF_2; pfam13185 383372010312 GAF domain; Region: GAF; cl15785 383372010313 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 383372010314 Zn2+ binding site [ion binding]; other site 383372010315 Mg2+ binding site [ion binding]; other site 383372010316 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372010317 S-adenosylmethionine binding site [chemical binding]; other site 383372010318 Thiamine pyrophosphokinase; Region: TPK; cd07995 383372010319 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 383372010320 active site 383372010321 dimerization interface [polypeptide binding]; other site 383372010322 thiamine binding site [chemical binding]; other site 383372010323 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 383372010324 Double zinc ribbon; Region: DZR; pfam12773 383372010325 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 383372010326 phosphopeptide binding site; other site 383372010327 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 383372010328 phosphopeptide binding site; other site 383372010329 ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with processes...; Region: ABCG_EPDR; cd03213 383372010330 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 383372010331 Walker A/P-loop; other site 383372010332 ATP binding site [chemical binding]; other site 383372010333 Q-loop/lid; other site 383372010334 ABC transporter signature motif; other site 383372010335 Walker B; other site 383372010336 D-loop; other site 383372010337 H-loop/switch region; other site 383372010338 ABC-2 type transporter; Region: ABC2_membrane; cl11417 383372010339 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 383372010340 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 383372010341 phosphopeptide binding site; other site 383372010342 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 383372010343 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 383372010344 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 383372010345 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 383372010346 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372010347 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 383372010348 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 383372010349 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 383372010350 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 383372010351 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372010352 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 383372010353 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 383372010354 dimerization interface [polypeptide binding]; other site 383372010355 putative DNA binding site [nucleotide binding]; other site 383372010356 putative Zn2+ binding site [ion binding]; other site 383372010357 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 383372010358 Predicted permease; Region: DUF318; pfam03773 383372010359 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 383372010360 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 383372010361 Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO)-like family, N-terminal TRX-fold subdomain; composed of proteins with similarity to PfPDO, a redox active thermostable protein believed to be the archaeal counterpart of bacterial DsbA and...; Region: PfPDO_like_N; cd02975 383372010362 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 383372010363 catalytic residues [active] 383372010364 Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973 383372010365 catalytic residues [active] 383372010366 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 383372010367 Transmembrane secretion effector; Region: MFS_3; pfam05977 383372010368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 383372010369 putative substrate translocation pore; other site 383372010370 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 383372010371 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 383372010372 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 383372010373 inhibitor-cofactor binding pocket; inhibition site 383372010374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372010375 catalytic residue [active] 383372010376 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 383372010377 putative ligand binding pocket/active site [active] 383372010378 putative metal binding site [ion binding]; other site 383372010379 Bacterial SH3 domain; Region: SH3_3; cl02551 383372010380 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 383372010381 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 383372010382 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 383372010383 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 383372010384 active site residue [active] 383372010385 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 383372010386 L-aspartate oxidase; Provisional; Region: PRK07395 383372010387 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 383372010388 Transcriptional regulator [Transcription]; Region: LysR; COG0583 383372010389 Helix-turn-helix domains; Region: HTH; cl00088 383372010390 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 383372010391 dimerization interface [polypeptide binding]; other site 383372010392 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 383372010393 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 383372010394 active site 383372010395 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 383372010396 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 383372010397 active site 383372010398 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 383372010399 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 383372010400 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 383372010401 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 383372010402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372010403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372010404 S-adenosylmethionine binding site [chemical binding]; other site 383372010405 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 383372010406 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 383372010407 Walker A/P-loop; other site 383372010408 ATP binding site [chemical binding]; other site 383372010409 Q-loop/lid; other site 383372010410 ABC transporter signature motif; other site 383372010411 Walker B; other site 383372010412 D-loop; other site 383372010413 H-loop/switch region; other site 383372010414 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 383372010415 putative carbohydrate binding site [chemical binding]; other site 383372010416 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 383372010417 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 383372010418 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 383372010419 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 383372010420 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 383372010421 active site 383372010422 ubiquinone biosynthesis O-methyltransferase; Region: UbiG; TIGR01983 383372010423 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372010424 inosine-5'-monophosphate dehydrogenase; Region: PLN02274 383372010425 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 383372010426 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 383372010427 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 383372010428 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 383372010429 active site 383372010430 ABC-2 type transporter; Region: ABC2_membrane; cl11417 383372010431 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 383372010432 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 383372010433 Probable transposase; Region: OrfB_IS605; pfam01385 383372010434 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 383372010435 Cupin domain; Region: Cupin_2; cl09118 383372010436 Protein of unknown function DUF86; Region: DUF86; cl01031 383372010437 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 383372010438 active site 383372010439 NTP binding site [chemical binding]; other site 383372010440 metal binding triad [ion binding]; metal-binding site 383372010441 antibiotic binding site [chemical binding]; other site 383372010442 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372010443 putative active site [active] 383372010444 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372010445 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 383372010446 NAD(P) binding site [chemical binding]; other site 383372010447 active site 383372010448 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 383372010449 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372010450 active site 383372010451 phosphorylation site [posttranslational modification] 383372010452 intermolecular recognition site; other site 383372010453 dimerization interface [polypeptide binding]; other site 383372010454 ANTAR domain; Region: ANTAR; cl04297 383372010455 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 383372010456 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 383372010457 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 383372010458 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 383372010459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372010460 active site 383372010461 phosphorylation site [posttranslational modification] 383372010462 intermolecular recognition site; other site 383372010463 dimerization interface [polypeptide binding]; other site 383372010464 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 383372010465 DNA binding site [nucleotide binding] 383372010466 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 383372010467 Rubrerythrin [Energy production and conversion]; Region: COG1592 383372010468 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 383372010469 dinuclear metal binding motif [ion binding]; other site 383372010470 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 383372010471 DinB superfamily; Region: DinB_2; pfam12867 383372010472 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 383372010473 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 383372010474 putative ADP-binding pocket [chemical binding]; other site 383372010475 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 383372010476 Chain length determinant protein; Region: Wzz; cl15801 383372010477 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 383372010478 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372010479 Response regulator receiver domain; Region: Response_reg; pfam00072 383372010480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372010481 active site 383372010482 phosphorylation site [posttranslational modification] 383372010483 intermolecular recognition site; other site 383372010484 dimerization interface [polypeptide binding]; other site 383372010485 PAS domain; Region: PAS_9; pfam13426 383372010486 GAF domain; Region: GAF; cl15785 383372010487 GAF domain; Region: GAF_2; pfam13185 383372010488 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 383372010489 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372010490 dimer interface [polypeptide binding]; other site 383372010491 phosphorylation site [posttranslational modification] 383372010492 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372010493 ATP binding site [chemical binding]; other site 383372010494 Mg2+ binding site [ion binding]; other site 383372010495 G-X-G motif; other site 383372010496 Response regulator receiver domain; Region: Response_reg; pfam00072 383372010497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372010498 active site 383372010499 phosphorylation site [posttranslational modification] 383372010500 intermolecular recognition site; other site 383372010501 dimerization interface [polypeptide binding]; other site 383372010502 methionine gamma-lyase; Validated; Region: PRK07049 383372010503 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 383372010504 homodimer interface [polypeptide binding]; other site 383372010505 substrate-cofactor binding pocket; other site 383372010506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372010507 catalytic residue [active] 383372010508 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 383372010509 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 383372010510 active site 383372010511 metal binding site [ion binding]; metal-binding site 383372010512 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 383372010513 active site 383372010514 ATP binding site [chemical binding]; other site 383372010515 Bacterial PH domain; Region: DUF304; cl01348 383372010516 GAF domain; Region: GAF; cl15785 383372010517 Bacterial transcriptional activator domain; Region: BTAD; smart01043 383372010518 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 383372010519 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 383372010520 DNA binding residues [nucleotide binding] 383372010521 short chain dehydrogenase; Provisional; Region: PRK06197 383372010522 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 383372010523 putative NAD(P) binding site [chemical binding]; other site 383372010524 active site 383372010525 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 383372010526 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 383372010527 ligand binding site [chemical binding]; other site 383372010528 flexible hinge region; other site 383372010529 Helix-turn-helix domains; Region: HTH; cl00088 383372010530 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 383372010531 Coenzyme A binding pocket [chemical binding]; other site 383372010532 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 383372010533 active site 383372010534 catalytic site [active] 383372010535 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 383372010536 active site 383372010537 putative substrate binding region [chemical binding]; other site 383372010538 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: Arch_glmU; TIGR03992 383372010539 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 383372010540 active site 383372010541 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 383372010542 putative trimer interface [polypeptide binding]; other site 383372010543 putative CoA binding site [chemical binding]; other site 383372010544 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 383372010545 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 383372010546 putative active site [active] 383372010547 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372010548 Cupin domain; Region: Cupin_2; cl09118 383372010549 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 383372010550 Helix-turn-helix domains; Region: HTH; cl00088 383372010551 Predicted ATPase [General function prediction only]; Region: COG3903 383372010552 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 383372010553 binding surface 383372010554 TPR motif; other site 383372010555 Tetratricopeptide repeat; Region: TPR_12; pfam13424 383372010556 Transposase IS200 like; Region: Y1_Tnp; cl00848 383372010557 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 383372010558 PA14 domain; Region: PA14; cl08459 383372010559 Mo-co oxidoreductase dimerisation domain; Region: Mo-co_dimer; pfam03404 383372010560 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 383372010561 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 383372010562 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 383372010563 CHAT domain; Region: CHAT; pfam12770 383372010564 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372010565 Predicted ATPase [General function prediction only]; Region: COG3903 383372010566 Tetratricopeptide repeat; Region: TPR_12; pfam13424 383372010567 Tetratricopeptide repeat; Region: TPR_12; pfam13424 383372010568 Tetratricopeptide repeat; Region: TPR_12; pfam13424 383372010569 Tetratricopeptide repeat; Region: TPR_12; pfam13424 383372010570 Tetratricopeptide repeat; Region: TPR_12; pfam13424 383372010571 Tetratricopeptide repeat; Region: TPR_12; pfam13424 383372010572 Tetratricopeptide repeat; Region: TPR_12; pfam13424 383372010573 Tetratricopeptide repeat; Region: TPR_12; pfam13424 383372010574 Tetratricopeptide repeat; Region: TPR_12; pfam13424 383372010575 Tetratricopeptide repeat; Region: TPR_12; pfam13424 383372010576 Tetratricopeptide repeat; Region: TPR_12; pfam13424 383372010577 Tetratricopeptide repeat; Region: TPR_12; pfam13424 383372010578 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 383372010579 active site 383372010580 Ap6A binding site [chemical binding]; other site 383372010581 nudix motif; other site 383372010582 metal binding site [ion binding]; metal-binding site 383372010583 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 383372010584 dimer interface [polypeptide binding]; other site 383372010585 substrate binding site [chemical binding]; other site 383372010586 metal binding sites [ion binding]; metal-binding site 383372010587 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 383372010588 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 383372010589 transcription termination factor Rho; Provisional; Region: rho; PRK09376 383372010590 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 383372010591 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 383372010592 RNA binding site [nucleotide binding]; other site 383372010593 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 383372010594 multimer interface [polypeptide binding]; other site 383372010595 Walker A motif; other site 383372010596 ATP binding site [chemical binding]; other site 383372010597 Walker B motif; other site 383372010598 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 383372010599 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 383372010600 motif 1; other site 383372010601 active site 383372010602 motif 2; other site 383372010603 motif 3; other site 383372010604 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 383372010605 DHHA1 domain; Region: DHHA1; pfam02272 383372010606 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 383372010607 Predicted kinase [General function prediction only]; Region: COG0645 383372010608 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372010609 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372010610 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 383372010611 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 383372010612 putative active site pocket [active] 383372010613 cleavage site 383372010614 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 383372010615 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 383372010616 Double zinc ribbon; Region: DZR; pfam12773 383372010617 Nitrogen regulatory protein P-II; Region: P-II; cl00412 383372010618 thymidylate kinase; Validated; Region: tmk; PRK00698 383372010619 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 383372010620 TMP-binding site; other site 383372010621 ATP-binding site [chemical binding]; other site 383372010622 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 383372010623 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 383372010624 Walker A motif; other site 383372010625 ATP binding site [chemical binding]; other site 383372010626 Walker B motif; other site 383372010627 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 383372010628 RxxxH motif; other site 383372010629 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 383372010630 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 383372010631 predicted active site [active] 383372010632 catalytic triad [active] 383372010633 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 383372010634 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 383372010635 active site 383372010636 multimer interface [polypeptide binding]; other site 383372010637 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 383372010638 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 383372010639 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 383372010640 Predicted transcriptional regulator [Transcription]; Region: COG2345 383372010641 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 383372010642 dimerization interface [polypeptide binding]; other site 383372010643 putative DNA binding site [nucleotide binding]; other site 383372010644 putative Zn2+ binding site [ion binding]; other site 383372010645 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 383372010646 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372010647 NAD(P) binding site [chemical binding]; other site 383372010648 active site 383372010649 hypothetical protein; Validated; Region: PRK07682 383372010650 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 383372010651 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372010652 homodimer interface [polypeptide binding]; other site 383372010653 catalytic residue [active] 383372010654 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 383372010655 Ligand binding site; other site 383372010656 Putative Catalytic site; other site 383372010657 DXD motif; other site 383372010658 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 383372010659 trimer interface [polypeptide binding]; other site 383372010660 active site 383372010661 dimer interface [polypeptide binding]; other site 383372010662 Right handed beta helix region; Region: Beta_helix; pfam13229 383372010663 Right handed beta helix region; Region: Beta_helix; pfam13229 383372010664 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 383372010665 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 383372010666 Colicin V production protein; Region: Colicin_V; cl00567 383372010667 Oligomerisation domain; Region: Oligomerisation; cl00519 383372010668 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 383372010669 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372010670 CoA-ligase; Region: Ligase_CoA; cl02894 383372010671 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 383372010672 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 383372010673 catalytic residue [active] 383372010674 Low molecular weight phosphatase family; Region: LMWPc; cd00115 383372010675 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 383372010676 active site 383372010677 chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014 383372010678 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 383372010679 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 383372010680 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 383372010681 chlorophyllide reductase subunit Y; Region: BchY; TIGR02015 383372010682 Uncharacterized ArCR, COG2043; Region: DUF169; cl00894 383372010683 chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016 383372010684 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372010685 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202 383372010686 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 383372010687 putative NAD(P) binding site [chemical binding]; other site 383372010688 2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; cl06353 383372010689 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 383372010690 Ligand Binding Site [chemical binding]; other site 383372010691 Protein of unknown function (DUF3623); Region: DUF3623; cl11843 383372010692 geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023 383372010693 UbiA prenyltransferase family; Region: UbiA; cl00337 383372010694 Cytochrome C subunit of the bacterial photosynthetic reaction center; Region: CytoC_RC; cd09224 383372010695 subunit interface [polypeptide binding]; other site 383372010696 Heme binding sites [chemical binding]; other site 383372010697 bifunctional photosynthetic reaction center subunit L/M; Provisional; Region: PRK14505 383372010698 Subunit L of bacterial photosynthetic reaction center; Region: Photo-RC_L; cd09290 383372010699 subunit M interface; other site 383372010700 subunit H interface; other site 383372010701 quinone binding site; other site 383372010702 bacteriopheophytin binding site; other site 383372010703 bacteriochlorophyll binding site; other site 383372010704 cytochrome C subunit interface; other site 383372010705 Fe binding site [ion binding]; other site 383372010706 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 383372010707 pheophytin binding site; other site 383372010708 chlorophyll binding site; other site 383372010709 quinone binding site; other site 383372010710 Fe binding site [ion binding]; other site 383372010711 Antenna complex alpha/beta subunit; Region: LHC; pfam00556 383372010712 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 383372010713 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 383372010714 DNA binding residues [nucleotide binding] 383372010715 B12 binding domain; Region: B12-binding_2; cl03653 383372010716 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 383372010717 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 383372010718 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 383372010719 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 383372010720 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 383372010721 Uncharacterized conserved protein [Function unknown]; Region: COG2308 383372010722 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 383372010723 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 383372010724 Histidine kinase; Region: HisKA_3; pfam07730 383372010725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372010726 ATP binding site [chemical binding]; other site 383372010727 Mg2+ binding site [ion binding]; other site 383372010728 G-X-G motif; other site 383372010729 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 383372010730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372010731 active site 383372010732 phosphorylation site [posttranslational modification] 383372010733 intermolecular recognition site; other site 383372010734 dimerization interface [polypeptide binding]; other site 383372010735 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 383372010736 DNA binding residues [nucleotide binding] 383372010737 dimerization interface [polypeptide binding]; other site 383372010738 ABC-2 type transporter; Region: ABC2_membrane; cl11417 383372010739 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 383372010740 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 383372010741 substrate binding site [chemical binding]; other site 383372010742 dimer interface [polypeptide binding]; other site 383372010743 ATP binding site [chemical binding]; other site 383372010744 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 383372010745 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 383372010746 motif II; other site 383372010747 LrgA family; Region: LrgA; cl00608 383372010748 LrgB-like family; Region: LrgB; cl00596 383372010749 classical (c) SDRs; Region: SDR_c; cd05233 383372010750 NAD(P) binding site [chemical binding]; other site 383372010751 active site 383372010752 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 383372010753 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 383372010754 homodimer interface [polypeptide binding]; other site 383372010755 active site 383372010756 TDP-binding site; other site 383372010757 acceptor substrate-binding pocket; other site 383372010758 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 383372010759 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 383372010760 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 383372010761 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372010762 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 383372010763 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 383372010764 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 383372010765 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 383372010766 Ligand Binding Site [chemical binding]; other site 383372010767 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 383372010768 Ligand Binding Site [chemical binding]; other site 383372010769 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 383372010770 Ligand Binding Site [chemical binding]; other site 383372010771 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 383372010772 Ligand Binding Site [chemical binding]; other site 383372010773 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 383372010774 Ligand Binding Site [chemical binding]; other site 383372010775 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 383372010776 FOG: CBS domain [General function prediction only]; Region: COG0517 383372010777 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 383372010778 FOG: CBS domain [General function prediction only]; Region: COG0517 383372010779 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 383372010780 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 383372010781 active site 383372010782 diiron metal binding site [ion binding]; other site 383372010783 Transcriptional regulator [Transcription]; Region: LysR; COG0583 383372010784 Helix-turn-helix domains; Region: HTH; cl00088 383372010785 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 383372010786 dimerization interface [polypeptide binding]; other site 383372010787 calcium/proton exchanger (cax); Region: cax; TIGR00378 383372010788 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 383372010789 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372010790 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 383372010791 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 383372010792 dimerization interface [polypeptide binding]; other site 383372010793 putative active cleft [active] 383372010794 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 383372010795 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 383372010796 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 383372010797 dimer interface [polypeptide binding]; other site 383372010798 anticodon binding site; other site 383372010799 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 383372010800 homodimer interface [polypeptide binding]; other site 383372010801 motif 1; other site 383372010802 active site 383372010803 motif 2; other site 383372010804 GAD domain; Region: GAD; pfam02938 383372010805 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 383372010806 active site 383372010807 motif 3; other site 383372010808 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 383372010809 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 383372010810 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372010811 putative active site [active] 383372010812 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372010813 putative active site [active] 383372010814 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 383372010815 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 383372010816 [2Fe-2S] cluster binding site [ion binding]; other site 383372010817 C-terminal catalytic domain of plant choline monooxygenase (CMO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_CMO-like; cd08883 383372010818 putative alpha subunit interface [polypeptide binding]; other site 383372010819 putative active site [active] 383372010820 putative substrate binding site [chemical binding]; other site 383372010821 Fe binding site [ion binding]; other site 383372010822 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 383372010823 dimerization interface [polypeptide binding]; other site 383372010824 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 383372010825 ATP binding site [chemical binding]; other site 383372010826 Hydrogenase formation hypA family; Region: HypD; cl12072 383372010827 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 383372010828 HupF/HypC family; Region: HupF_HypC; cl00394 383372010829 NifU-like domain; Region: NifU; cl00484 383372010830 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 383372010831 iron-sulfur cluster [ion binding]; other site 383372010832 [2Fe-2S] cluster binding site [ion binding]; other site 383372010833 This group of endopeptidases include HupW enzymes that are specific to the cyanobacterial hydrogenase and are involved in the C-terminal cleavage of the hydrogenase large subunit precursor protein. Cyanobacterial nickel-iron (NiFe)-hydrogenases are found...; Region: H2MP_Cyano-H2up; cd06063 383372010834 nickel binding site [ion binding]; other site 383372010835 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 383372010836 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 383372010837 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372010838 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 383372010839 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 383372010840 hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418 383372010841 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 383372010842 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 383372010843 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 383372010844 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 383372010845 active site 383372010846 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 383372010847 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 383372010848 inhibitor-cofactor binding pocket; inhibition site 383372010849 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372010850 catalytic residue [active] 383372010851 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 383372010852 MoxR-like ATPases [General function prediction only]; Region: COG0714 383372010853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 383372010854 Walker A motif; other site 383372010855 ATP binding site [chemical binding]; other site 383372010856 Walker B motif; other site 383372010857 arginine finger; other site 383372010858 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 383372010859 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 383372010860 Aerotolerance regulator N-terminal; Region: BatA; cl06567 383372010861 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 383372010862 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 383372010863 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 383372010864 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 383372010865 metal ion-dependent adhesion site (MIDAS); other site 383372010866 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 383372010867 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 383372010868 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 383372010869 Phosphotransferase enzyme family; Region: APH; pfam01636 383372010870 active site 383372010871 substrate binding site [chemical binding]; other site 383372010872 ATP binding site [chemical binding]; other site 383372010873 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 383372010874 GAF domain; Region: GAF_2; pfam13185 383372010875 GAF domain; Region: GAF; cl15785 383372010876 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372010877 dimer interface [polypeptide binding]; other site 383372010878 phosphorylation site [posttranslational modification] 383372010879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372010880 ATP binding site [chemical binding]; other site 383372010881 Mg2+ binding site [ion binding]; other site 383372010882 G-X-G motif; other site 383372010883 Response regulator receiver domain; Region: Response_reg; pfam00072 383372010884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372010885 active site 383372010886 phosphorylation site [posttranslational modification] 383372010887 intermolecular recognition site; other site 383372010888 dimerization interface [polypeptide binding]; other site 383372010889 shikimate kinase; Reviewed; Region: aroK; PRK00131 383372010890 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372010891 active site 383372010892 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 383372010893 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 383372010894 AMP-binding enzyme; Region: AMP-binding; cl15778 383372010895 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 383372010896 Tetramer interface [polypeptide binding]; other site 383372010897 active site 383372010898 FMN-binding site [chemical binding]; other site 383372010899 TPR repeat; Region: TPR_11; pfam13414 383372010900 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372010901 binding surface 383372010902 TPR motif; other site 383372010903 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 383372010904 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 383372010905 active site 383372010906 GAF domain; Region: GAF_2; pfam13185 383372010907 GAF domain; Region: GAF; cl15785 383372010908 GAF domain; Region: GAF_2; pfam13185 383372010909 GAF domain; Region: GAF; cl15785 383372010910 GAF domain; Region: GAF; cl15785 383372010911 GAF domain; Region: GAF_2; pfam13185 383372010912 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 383372010913 metal binding site [ion binding]; metal-binding site 383372010914 active site 383372010915 I-site; other site 383372010916 Transglycosylase; Region: Transgly; cl07896 383372010917 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 383372010918 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 383372010919 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 383372010920 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 383372010921 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 383372010922 DNA binding site [nucleotide binding] 383372010923 catalytic residue [active] 383372010924 H2TH interface [polypeptide binding]; other site 383372010925 putative catalytic residues [active] 383372010926 turnover-facilitating residue; other site 383372010927 intercalation triad [nucleotide binding]; other site 383372010928 8OG recognition residue [nucleotide binding]; other site 383372010929 putative reading head residues; other site 383372010930 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 383372010931 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 383372010932 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 383372010933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372010934 dimer interface [polypeptide binding]; other site 383372010935 conserved gate region; other site 383372010936 putative PBP binding loops; other site 383372010937 ABC-ATPase subunit interface; other site 383372010938 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 383372010939 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372010940 dimer interface [polypeptide binding]; other site 383372010941 conserved gate region; other site 383372010942 putative PBP binding loops; other site 383372010943 ABC-ATPase subunit interface; other site 383372010944 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 383372010945 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 383372010946 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 383372010947 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 383372010948 inhibitor-cofactor binding pocket; inhibition site 383372010949 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372010950 catalytic residue [active] 383372010951 Transcriptional regulators [Transcription]; Region: GntR; COG1802 383372010952 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 383372010953 DNA-binding site [nucleotide binding]; DNA binding site 383372010954 FCD domain; Region: FCD; cl11656 383372010955 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 383372010956 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 383372010957 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 383372010958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372010959 dimer interface [polypeptide binding]; other site 383372010960 conserved gate region; other site 383372010961 putative PBP binding loops; other site 383372010962 ABC-ATPase subunit interface; other site 383372010963 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 383372010964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 383372010965 dimer interface [polypeptide binding]; other site 383372010966 conserved gate region; other site 383372010967 putative PBP binding loops; other site 383372010968 ABC-ATPase subunit interface; other site 383372010969 galactonate dehydratase; Provisional; Region: PRK14017 383372010970 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 383372010971 metal binding site [ion binding]; metal-binding site 383372010972 substrate binding pocket [chemical binding]; other site 383372010973 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 383372010974 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 383372010975 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 383372010976 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 383372010977 classical (c) SDRs; Region: SDR_c; cd05233 383372010978 NAD(P) binding site [chemical binding]; other site 383372010979 active site 383372010980 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 383372010981 DNA-binding site [nucleotide binding]; DNA binding site 383372010982 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 383372010983 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 383372010984 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 383372010985 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 383372010986 putative active site [active] 383372010987 Zn binding site [ion binding]; other site 383372010988 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 383372010989 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 383372010990 active site pocket [active] 383372010991 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 383372010992 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 383372010993 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 383372010994 dimerization interface [polypeptide binding]; other site 383372010995 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 383372010996 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372010997 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 383372010998 Restriction endonuclease; Region: Mrr_cat; cl00516 383372010999 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331 383372011000 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 383372011001 active site 383372011002 catalytic site [active] 383372011003 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 383372011004 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372011005 putative active site [active] 383372011006 BtpA family; Region: BtpA; cl00440 383372011007 pteridine reductase; Provisional; Region: PRK09135 383372011008 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372011009 NAD(P) binding site [chemical binding]; other site 383372011010 active site 383372011011 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 383372011012 trimer interface [polypeptide binding]; other site 383372011013 dimer interface [polypeptide binding]; other site 383372011014 putative active site [active] 383372011015 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 383372011016 heterodimer interface [polypeptide binding]; other site 383372011017 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 383372011018 substrate interaction site [chemical binding]; other site 383372011019 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 383372011020 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 383372011021 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 383372011022 active site 383372011023 substrate binding site [chemical binding]; other site 383372011024 coenzyme B12 binding site [chemical binding]; other site 383372011025 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 383372011026 B12 binding site [chemical binding]; other site 383372011027 cobalt ligand [ion binding]; other site 383372011028 membrane ATPase/protein kinase; Provisional; Region: PRK09435 383372011029 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372011030 GTP/Mg2+ binding site [chemical binding]; other site 383372011031 G5 box; other site 383372011032 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 383372011033 Walker A; other site 383372011034 G1 box; other site 383372011035 Helix-turn-helix domains; Region: HTH; cl00088 383372011036 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 383372011037 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 383372011038 FeoA domain; Region: FeoA; cl00838 383372011039 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 383372011040 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 383372011041 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 383372011042 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 383372011043 substrate binding pocket [chemical binding]; other site 383372011044 dimer interface [polypeptide binding]; other site 383372011045 inhibitor binding site; inhibition site 383372011046 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 383372011047 B12 binding site [chemical binding]; other site 383372011048 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 383372011049 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 383372011050 intersubunit interface [polypeptide binding]; other site 383372011051 active site 383372011052 Zn2+ binding site [ion binding]; other site 383372011053 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372011054 NAD(P) binding site [chemical binding]; other site 383372011055 active site 383372011056 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 383372011057 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 383372011058 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 383372011059 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 383372011060 PAS fold; Region: PAS_3; pfam08447 383372011061 putative active site [active] 383372011062 heme pocket [chemical binding]; other site 383372011063 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372011064 dimer interface [polypeptide binding]; other site 383372011065 phosphorylation site [posttranslational modification] 383372011066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372011067 ATP binding site [chemical binding]; other site 383372011068 Mg2+ binding site [ion binding]; other site 383372011069 G-X-G motif; other site 383372011070 Response regulator receiver domain; Region: Response_reg; pfam00072 383372011071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372011072 active site 383372011073 phosphorylation site [posttranslational modification] 383372011074 intermolecular recognition site; other site 383372011075 dimerization interface [polypeptide binding]; other site 383372011076 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 383372011077 Predicted membrane protein [Function unknown]; Region: COG3463 383372011078 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 383372011079 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 383372011080 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372011081 TPR motif; other site 383372011082 binding surface 383372011083 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 383372011084 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372011085 S-adenosylmethionine binding site [chemical binding]; other site 383372011086 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 383372011087 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 383372011088 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 383372011089 Predicted permease; Region: DUF318; pfam03773 383372011090 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 383372011091 metal binding site 2 [ion binding]; metal-binding site 383372011092 putative DNA binding helix; other site 383372011093 metal binding site 1 [ion binding]; metal-binding site 383372011094 dimer interface [polypeptide binding]; other site 383372011095 structural Zn2+ binding site [ion binding]; other site 383372011096 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 383372011097 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 383372011098 ligand binding site [chemical binding]; other site 383372011099 flexible hinge region; other site 383372011100 Helix-turn-helix domains; Region: HTH; cl00088 383372011101 Probable zinc-binding domain; Region: zf-trcl; pfam13451 383372011102 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 383372011103 DNA-binding site [nucleotide binding]; DNA binding site 383372011104 RNA-binding motif; other site 383372011105 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 383372011106 metal binding site 2 [ion binding]; metal-binding site 383372011107 putative DNA binding helix; other site 383372011108 metal binding site 1 [ion binding]; metal-binding site 383372011109 dimer interface [polypeptide binding]; other site 383372011110 structural Zn2+ binding site [ion binding]; other site 383372011111 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 383372011112 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 383372011113 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 383372011114 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372011115 NAD(P) binding site [chemical binding]; other site 383372011116 active site 383372011117 ornithine cyclodeaminase; Validated; Region: PRK08618 383372011118 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372011119 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 383372011120 ligand binding site [chemical binding]; other site 383372011121 flexible hinge region; other site 383372011122 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 383372011123 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372011124 NAD(P) binding site [chemical binding]; other site 383372011125 active site 383372011126 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 383372011127 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_5; cd11352 383372011128 active site 383372011129 catalytic site [active] 383372011130 HEAT repeats; Region: HEAT_2; pfam13646 383372011131 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 383372011132 active site 383372011133 NTP binding site [chemical binding]; other site 383372011134 metal binding triad [ion binding]; metal-binding site 383372011135 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl15461 383372011136 HEPN domain; Region: HEPN; cl00824 383372011137 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 383372011138 active site 383372011139 NTP binding site [chemical binding]; other site 383372011140 metal binding triad [ion binding]; metal-binding site 383372011141 antibiotic binding site [chemical binding]; other site 383372011142 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 383372011143 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 383372011144 rRNA interaction site [nucleotide binding]; other site 383372011145 S8 interaction site; other site 383372011146 putative laminin-1 binding site; other site 383372011147 elongation factor Ts; Reviewed; Region: tsf; PRK12332 383372011148 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 383372011149 Elongation factor TS; Region: EF_TS; pfam00889 383372011150 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 383372011151 putative nucleotide binding site [chemical binding]; other site 383372011152 uridine monophosphate binding site [chemical binding]; other site 383372011153 homohexameric interface [polypeptide binding]; other site 383372011154 ribosome recycling factor; Reviewed; Region: frr; PRK00083 383372011155 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 383372011156 hinge region; other site 383372011157 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 383372011158 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 383372011159 catalytic residue [active] 383372011160 putative FPP diphosphate binding site; other site 383372011161 putative FPP binding hydrophobic cleft; other site 383372011162 dimer interface [polypeptide binding]; other site 383372011163 putative IPP diphosphate binding site; other site 383372011164 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 383372011165 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 383372011166 DHH family; Region: DHH; pfam01368 383372011167 DHHA1 domain; Region: DHHA1; pfam02272 383372011168 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 383372011169 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 383372011170 ligand binding site [chemical binding]; other site 383372011171 flexible hinge region; other site 383372011172 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 383372011173 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 383372011174 metal binding triad; other site 383372011175 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 383372011176 active site 383372011177 substrate binding site [chemical binding]; other site 383372011178 catalytic site [active] 383372011179 acetyl-CoA synthetase; Provisional; Region: PRK00174 383372011180 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 383372011181 AMP-binding enzyme; Region: AMP-binding; cl15778 383372011182 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 383372011183 acetyl-CoA synthetase; Provisional; Region: PRK00174 383372011184 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 383372011185 AMP-binding enzyme; Region: AMP-binding; cl15778 383372011186 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 383372011187 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 383372011188 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 383372011189 ribonuclease PH; Reviewed; Region: rph; PRK00173 383372011190 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 383372011191 oligomer interface [polypeptide binding]; other site 383372011192 RNA binding site [nucleotide binding]; other site 383372011193 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 383372011194 Bacterial Ig-like domain; Region: Big_5; cl01012 383372011195 Bacterial Ig-like domain; Region: Big_5; cl01012 383372011196 Bacterial Ig-like domain; Region: Big_5; cl01012 383372011197 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 383372011198 MG2 domain; Region: A2M_N; pfam01835 383372011199 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 383372011200 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 383372011201 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 383372011202 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 383372011203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372011204 S-adenosylmethionine binding site [chemical binding]; other site 383372011205 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 383372011206 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 383372011207 active site 383372011208 catalytic residues [active] 383372011209 Helix-turn-helix domains; Region: HTH; cl00088 383372011210 Adenosine specific kinase; Region: Adenosine_kin; cl00796 383372011211 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 383372011212 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 383372011213 GatB domain; Region: GatB_Yqey; cl11497 383372011214 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 383372011215 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 383372011216 Putative esterase; Region: Esterase; pfam00756 383372011217 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 383372011218 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 383372011219 Walker A/P-loop; other site 383372011220 ATP binding site [chemical binding]; other site 383372011221 Q-loop/lid; other site 383372011222 ABC transporter signature motif; other site 383372011223 Walker B; other site 383372011224 D-loop; other site 383372011225 H-loop/switch region; other site 383372011226 Predicted periplasmic protein [Function unknown]; Region: COG3698 383372011227 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 383372011228 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 383372011229 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 383372011230 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 383372011231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 383372011232 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 383372011233 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 383372011234 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 383372011235 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 383372011236 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 383372011237 protein binding site [polypeptide binding]; other site 383372011238 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 383372011239 Domain interface; other site 383372011240 Peptide binding site; other site 383372011241 Active site tetrad [active] 383372011242 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 383372011243 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 383372011244 putative active site pocket [active] 383372011245 4-fold oligomerization interface [polypeptide binding]; other site 383372011246 metal binding residues [ion binding]; metal-binding site 383372011247 3-fold/trimer interface [polypeptide binding]; other site 383372011248 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 383372011249 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 383372011250 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 383372011251 active site 383372011252 NTP binding site [chemical binding]; other site 383372011253 metal binding triad [ion binding]; metal-binding site 383372011254 antibiotic binding site [chemical binding]; other site 383372011255 Protein of unknown function DUF86; Region: DUF86; cl01031 383372011256 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 383372011257 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 383372011258 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 383372011259 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 383372011260 classical (c) SDRs; Region: SDR_c; cd05233 383372011261 NAD(P) binding site [chemical binding]; other site 383372011262 active site 383372011263 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 383372011264 AMP-binding enzyme; Region: AMP-binding; cl15778 383372011265 AMP-binding enzyme; Region: AMP-binding; cl15778 383372011266 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931 383372011267 putative active site [active] 383372011268 putative catalytic site [active] 383372011269 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 383372011270 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 383372011271 putative trimer interface [polypeptide binding]; other site 383372011272 putative CoA binding site [chemical binding]; other site 383372011273 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 383372011274 trimer interface [polypeptide binding]; other site 383372011275 active site 383372011276 substrate binding site [chemical binding]; other site 383372011277 CoA binding site [chemical binding]; other site 383372011278 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 383372011279 Ligand binding site; other site 383372011280 Putative Catalytic site; other site 383372011281 DXD motif; other site 383372011282 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 383372011283 active site 383372011284 homodimer interface [polypeptide binding]; other site 383372011285 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 383372011286 hypothetical protein; Provisional; Region: PRK07233 383372011287 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 383372011288 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372011289 Bacterial sugar transferase; Region: Bac_transf; cl00939 383372011290 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372011291 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 383372011292 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 383372011293 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 383372011294 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 383372011295 putative FMN binding site [chemical binding]; other site 383372011296 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 383372011297 phosphate binding site [ion binding]; other site 383372011298 dimer interface [polypeptide binding]; other site 383372011299 substrate binding site [chemical binding]; other site 383372011300 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 383372011301 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 383372011302 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 383372011303 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 383372011304 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 383372011305 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 383372011306 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 383372011307 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 383372011308 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 383372011309 YbbR-like protein; Region: YbbR; pfam07949 383372011310 Uncharacterized conserved protein [Function unknown]; Region: COG1624 383372011311 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 383372011312 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372011313 TPR motif; other site 383372011314 binding surface 383372011315 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372011316 binding surface 383372011317 TPR motif; other site 383372011318 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 383372011319 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 383372011320 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372011321 TPR motif; other site 383372011322 binding surface 383372011323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372011324 binding surface 383372011325 TPR motif; other site 383372011326 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 383372011327 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 383372011328 Walker A motif; other site 383372011329 ATP binding site [chemical binding]; other site 383372011330 Walker B motif; other site 383372011331 arginine finger; other site 383372011332 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 383372011333 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 383372011334 replicative DNA helicase; Region: DnaB; TIGR00665 383372011335 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 383372011336 Walker A motif; other site 383372011337 ATP binding site [chemical binding]; other site 383372011338 Walker B motif; other site 383372011339 DNA binding loops [nucleotide binding] 383372011340 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 383372011341 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 383372011342 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 383372011343 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 383372011344 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 383372011345 motif II; other site 383372011346 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 383372011347 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 383372011348 active site 383372011349 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 383372011350 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 383372011351 23S rRNA interface [nucleotide binding]; other site 383372011352 L3 interface [polypeptide binding]; other site 383372011353 tRNA pseudouridine synthase ACD; Provisional; Region: PRK14588 383372011354 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 383372011355 dimerization interface 3.5A [polypeptide binding]; other site 383372011356 active site 383372011357 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 383372011358 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 383372011359 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 383372011360 alphaNTD homodimer interface [polypeptide binding]; other site 383372011361 alphaNTD - beta interaction site [polypeptide binding]; other site 383372011362 alphaNTD - beta' interaction site [polypeptide binding]; other site 383372011363 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 383372011364 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 383372011365 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 383372011366 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 383372011367 RNA binding surface [nucleotide binding]; other site 383372011368 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 383372011369 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 383372011370 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 383372011371 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 383372011372 rRNA binding site [nucleotide binding]; other site 383372011373 predicted 30S ribosome binding site; other site 383372011374 adenylate kinase; Reviewed; Region: adk; PRK00279 383372011375 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 383372011376 AMP-binding site [chemical binding]; other site 383372011377 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 383372011378 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 383372011379 SecY translocase; Region: SecY; pfam00344 383372011380 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 383372011381 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 383372011382 23S rRNA binding site [nucleotide binding]; other site 383372011383 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 383372011384 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 383372011385 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 383372011386 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 383372011387 5S rRNA interface [nucleotide binding]; other site 383372011388 L27 interface [polypeptide binding]; other site 383372011389 23S rRNA interface [nucleotide binding]; other site 383372011390 L5 interface [polypeptide binding]; other site 383372011391 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 383372011392 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 383372011393 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 383372011394 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 383372011395 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 383372011396 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 383372011397 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 383372011398 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 383372011399 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 383372011400 KOW motif; Region: KOW; cl00354 383372011401 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 383372011402 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 383372011403 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 383372011404 putative translocon interaction site; other site 383372011405 23S rRNA interface [nucleotide binding]; other site 383372011406 signal recognition particle (SRP54) interaction site; other site 383372011407 L23 interface [polypeptide binding]; other site 383372011408 trigger factor interaction site; other site 383372011409 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 383372011410 23S rRNA interface [nucleotide binding]; other site 383372011411 5S rRNA interface [nucleotide binding]; other site 383372011412 putative antibiotic binding site [chemical binding]; other site 383372011413 L25 interface [polypeptide binding]; other site 383372011414 L27 interface [polypeptide binding]; other site 383372011415 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 383372011416 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 383372011417 G-X-X-G motif; other site 383372011418 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 383372011419 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 383372011420 putative translocon binding site; other site 383372011421 protein-rRNA interface [nucleotide binding]; other site 383372011422 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 383372011423 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 383372011424 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 383372011425 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 383372011426 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 383372011427 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 383372011428 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 383372011429 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 383372011430 elongation factor Tu; Reviewed; Region: PRK00049 383372011431 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 383372011432 G1 box; other site 383372011433 GEF interaction site [polypeptide binding]; other site 383372011434 GTP/Mg2+ binding site [chemical binding]; other site 383372011435 Switch I region; other site 383372011436 G2 box; other site 383372011437 G3 box; other site 383372011438 Switch II region; other site 383372011439 G4 box; other site 383372011440 G5 box; other site 383372011441 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 383372011442 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 383372011443 Antibiotic Binding Site [chemical binding]; other site 383372011444 elongation factor G; Reviewed; Region: PRK00007 383372011445 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 383372011446 G1 box; other site 383372011447 putative GEF interaction site [polypeptide binding]; other site 383372011448 GTP/Mg2+ binding site [chemical binding]; other site 383372011449 Switch I region; other site 383372011450 G2 box; other site 383372011451 G3 box; other site 383372011452 Switch II region; other site 383372011453 G4 box; other site 383372011454 G5 box; other site 383372011455 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 383372011456 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 383372011457 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 383372011458 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 383372011459 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 383372011460 16S rRNA interaction site [nucleotide binding]; other site 383372011461 streptomycin interaction site [chemical binding]; other site 383372011462 23S rRNA interaction site [nucleotide binding]; other site 383372011463 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 383372011464 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 383372011465 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 383372011466 NgoMIV restriction enzyme; Region: NgoMIV_restric; pfam09015 383372011467 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372011468 Predicted archaeal methyltransferase [General function prediction only]; Region: COG2521 383372011469 Nitrogenase_MoFe_beta_like: Nitrogenase MoFe protein, beta subunit_like. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen (N2) to ammonia. This group contains the beta subunits of component 1 of the three known genetically...; Region: Nitrogenase_MoFe_beta_like; cd01965 383372011470 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 383372011471 nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284 383372011472 Nitrogenase_MoFe_alpha_like: Nitrogenase MoFe protein, alpha subunit_like. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. Three genetically distinct types of nitrogenase systems are known to exist: a...; Region: Nitrogenase_MoFe_alpha_like; cd01967 383372011473 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 383372011474 Radical SAM superfamily; Region: Radical_SAM; pfam04055 383372011475 FeS/SAM binding site; other site 383372011476 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 383372011477 nitrogenase iron protein; Region: nifH; TIGR01287 383372011478 Nucleotide-binding sites [chemical binding]; other site 383372011479 Walker A motif; other site 383372011480 Switch I region of nucleotide binding site; other site 383372011481 Fe4S4 binding sites [ion binding]; other site 383372011482 Switch II region of nucleotide binding site; other site 383372011483 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 383372011484 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 383372011485 FtsX-like permease family; Region: FtsX; cl15850 383372011486 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cl03181 383372011487 active site 383372011488 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372011489 Putative cyclase; Region: Cyclase; cl00814 383372011490 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 383372011491 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 383372011492 dimer interface [polypeptide binding]; other site 383372011493 PYR/PP interface [polypeptide binding]; other site 383372011494 TPP binding site [chemical binding]; other site 383372011495 substrate binding site [chemical binding]; other site 383372011496 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 383372011497 Domain of unknown function; Region: EKR; cl11037 383372011498 4Fe-4S binding domain; Region: Fer4; cl02805 383372011499 4Fe-4S binding domain; Region: Fer4; cl02805 383372011500 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 383372011501 TPP-binding site [chemical binding]; other site 383372011502 dimer interface [polypeptide binding]; other site 383372011503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 383372011504 Major Facilitator Superfamily; Region: MFS_1; pfam07690 383372011505 putative substrate translocation pore; other site 383372011506 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 383372011507 MatE; Region: MatE; cl10513 383372011508 MatE; Region: MatE; cl10513 383372011509 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 383372011510 putative active site [active] 383372011511 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 383372011512 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 383372011513 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 383372011514 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 383372011515 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 383372011516 AAK_FomA-like: This CD includes a fosfomycin biosynthetic gene product, FomA, and similar proteins found in a wide range of organisms. Together, the fomA and fomB genes in the fosfomycin biosynthetic gene cluster of Streptomyces wedmorensis confer...; Region: AAK_FomA-like; cd04241 383372011517 putative nucleotide binding site [chemical binding]; other site 383372011518 putative substrate binding site [chemical binding]; other site 383372011519 UbiA prenyltransferase family; Region: UbiA; cl00337 383372011520 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 383372011521 active site 383372011522 dimerization interface [polypeptide binding]; other site 383372011523 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 383372011524 Protein of unknown function (DUF524); Region: DUF524; pfam04411 383372011525 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 383372011526 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 383372011527 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372011528 Family description; Region: UvrD_C_2; cl15862 383372011529 Transposase domain (DUF772); Region: DUF772; cl15789 383372011530 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372011531 hypothetical protein; Provisional; Region: PRK13560 383372011532 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 383372011533 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 383372011534 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 383372011535 translocation protein TolB; Provisional; Region: tolB; PRK00178 383372011536 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 383372011537 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 383372011538 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 383372011539 protein binding site [polypeptide binding]; other site 383372011540 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 383372011541 Catalytic dyad [active] 383372011542 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 383372011543 active site 383372011544 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 383372011545 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 383372011546 Mg++ binding site [ion binding]; other site 383372011547 putative catalytic motif [active] 383372011548 substrate binding site [chemical binding]; other site 383372011549 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 383372011550 substrate binding site [chemical binding]; other site 383372011551 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 383372011552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372011553 S-adenosylmethionine binding site [chemical binding]; other site 383372011554 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 383372011555 Fe-S cluster binding site [ion binding]; other site 383372011556 active site 383372011557 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 383372011558 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 383372011559 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 383372011560 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 383372011561 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 383372011562 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 383372011563 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 383372011564 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 383372011565 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 383372011566 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 383372011567 active site 383372011568 Substrate binding site; other site 383372011569 Mg++ binding site; other site 383372011570 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 383372011571 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 383372011572 Walker A motif; other site 383372011573 ATP binding site [chemical binding]; other site 383372011574 Walker B motif; other site 383372011575 arginine finger; other site 383372011576 Protein of unknown function (DUF503); Region: DUF503; cl00669 383372011577 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 383372011578 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 383372011579 heterotetramer interface [polypeptide binding]; other site 383372011580 active site pocket [active] 383372011581 cleavage site 383372011582 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 383372011583 PUA domain; Region: PUA; cl00607 383372011584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 383372011585 Cupin domain; Region: Cupin_2; cl09118 383372011586 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 383372011587 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 383372011588 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372011589 Walker A/P-loop; other site 383372011590 ATP binding site [chemical binding]; other site 383372011591 Q-loop/lid; other site 383372011592 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 383372011593 ABC transporter signature motif; other site 383372011594 Walker B; other site 383372011595 D-loop; other site 383372011596 H-loop/switch region; other site 383372011597 argininosuccinate lyase; Provisional; Region: PRK02186 383372011598 ATP-grasp domain; Region: ATP-grasp_4; cl03087 383372011599 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 383372011600 dimer interface [polypeptide binding]; other site 383372011601 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 383372011602 dimer interface [polypeptide binding]; other site 383372011603 Major Facilitator Superfamily; Region: MFS_1; pfam07690 383372011604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 383372011605 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 383372011606 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 383372011607 anti sigma factor interaction site; other site 383372011608 regulatory phosphorylation site [posttranslational modification]; other site 383372011609 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 383372011610 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 383372011611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 383372011612 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 383372011613 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 383372011614 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 383372011615 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 383372011616 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 383372011617 catalytic residues [active] 383372011618 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 383372011619 putative homotetramer interface [polypeptide binding]; other site 383372011620 putative homodimer interface [polypeptide binding]; other site 383372011621 putative allosteric switch controlling residues; other site 383372011622 putative metal binding site [ion binding]; other site 383372011623 putative homodimer-homodimer interface [polypeptide binding]; other site 383372011624 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 383372011625 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 383372011626 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 383372011627 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 383372011628 Dak1 domain; Region: Dak1; pfam02733 383372011629 DAK2 domain; Region: Dak2; cl03685 383372011630 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 383372011631 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 383372011632 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 383372011633 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372011634 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 383372011635 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 383372011636 Cysteine-rich domain; Region: CCG; pfam02754 383372011637 Cysteine-rich domain; Region: CCG; pfam02754 383372011638 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 383372011639 active pocket/dimerization site; other site 383372011640 active site 383372011641 phosphorylation site [posttranslational modification] 383372011642 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 383372011643 dimerization domain swap beta strand [polypeptide binding]; other site 383372011644 regulatory protein interface [polypeptide binding]; other site 383372011645 active site 383372011646 regulatory phosphorylation site [posttranslational modification]; other site 383372011647 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 383372011648 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 383372011649 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 383372011650 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 383372011651 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 383372011652 Catalytic domain of Protein Kinases; Region: PKc; cd00180 383372011653 active site 383372011654 ATP binding site [chemical binding]; other site 383372011655 substrate binding site [chemical binding]; other site 383372011656 activation loop (A-loop); other site 383372011657 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 383372011658 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 383372011659 active site 383372011660 NTP binding site [chemical binding]; other site 383372011661 metal binding triad [ion binding]; metal-binding site 383372011662 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 383372011663 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 383372011664 Zn2+ binding site [ion binding]; other site 383372011665 Mg2+ binding site [ion binding]; other site 383372011666 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 383372011667 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 383372011668 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 383372011669 putative dimer interface [polypeptide binding]; other site 383372011670 Peptidase family M48; Region: Peptidase_M48; cl12018 383372011671 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 383372011672 thiamine phosphate binding site [chemical binding]; other site 383372011673 active site 383372011674 pyrophosphate binding site [ion binding]; other site 383372011675 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 383372011676 substrate binding site [chemical binding]; other site 383372011677 multimerization interface [polypeptide binding]; other site 383372011678 ATP binding site [chemical binding]; other site 383372011679 Thiamine-precursor transporter protein (ThiW); Region: ThiW; cl01952 383372011680 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 383372011681 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 383372011682 Walker A/P-loop; other site 383372011683 ATP binding site [chemical binding]; other site 383372011684 Q-loop/lid; other site 383372011685 ABC transporter signature motif; other site 383372011686 Walker B; other site 383372011687 D-loop; other site 383372011688 H-loop/switch region; other site 383372011689 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 383372011690 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 383372011691 Walker A/P-loop; other site 383372011692 ATP binding site [chemical binding]; other site 383372011693 Q-loop/lid; other site 383372011694 ABC transporter signature motif; other site 383372011695 Walker B; other site 383372011696 D-loop; other site 383372011697 H-loop/switch region; other site 383372011698 Cobalt transport protein; Region: CbiQ; cl00463 383372011699 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 383372011700 dimer interface [polypeptide binding]; other site 383372011701 substrate binding site [chemical binding]; other site 383372011702 ATP binding site [chemical binding]; other site 383372011703 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 383372011704 active site 383372011705 NTP binding site [chemical binding]; other site 383372011706 metal binding triad [ion binding]; metal-binding site 383372011707 antibiotic binding site [chemical binding]; other site 383372011708 HEPN domain; Region: HEPN; cl00824 383372011709 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 383372011710 structural tetrad; other site 383372011711 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 383372011712 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 383372011713 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 383372011714 PAS fold; Region: PAS; pfam00989 383372011715 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 383372011716 putative active site [active] 383372011717 heme pocket [chemical binding]; other site 383372011718 GAF domain; Region: GAF_2; pfam13185 383372011719 GAF domain; Region: GAF; cl15785 383372011720 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 383372011721 Zn2+ binding site [ion binding]; other site 383372011722 Mg2+ binding site [ion binding]; other site 383372011723 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 383372011724 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 383372011725 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 383372011726 Probable Catalytic site; other site 383372011727 metal-binding site 383372011728 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 383372011729 ABC-2 type transporter; Region: ABC2_membrane; cl11417 383372011730 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 383372011731 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 383372011732 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 383372011733 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 383372011734 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 383372011735 FAD binding domain; Region: FAD_binding_4; pfam01565 383372011736 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 383372011737 putative active site [active] 383372011738 FAD binding domain; Region: FAD_binding_4; pfam01565 383372011739 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 383372011740 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 383372011741 putative peptidoglycan binding site; other site 383372011742 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 383372011743 putative peptidoglycan binding site; other site 383372011744 circadian clock protein KaiC; Reviewed; Region: PRK09302 383372011745 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 383372011746 Walker A motif; other site 383372011747 ATP binding site [chemical binding]; other site 383372011748 Walker B motif; other site 383372011749 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372011750 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372011751 Walker A motif; other site 383372011752 ATP binding site [chemical binding]; other site 383372011753 Walker B motif; other site 383372011754 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 383372011755 tetramer interface [polypeptide binding]; other site 383372011756 dimer interface [polypeptide binding]; other site 383372011757 Response regulator receiver domain; Region: Response_reg; pfam00072 383372011758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372011759 active site 383372011760 dimerization interface [polypeptide binding]; other site 383372011761 sensory histidine kinase AtoS; Provisional; Region: PRK11360 383372011762 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372011763 dimer interface [polypeptide binding]; other site 383372011764 phosphorylation site [posttranslational modification] 383372011765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372011766 ATP binding site [chemical binding]; other site 383372011767 Mg2+ binding site [ion binding]; other site 383372011768 G-X-G motif; other site 383372011769 Response regulator receiver domain; Region: Response_reg; pfam00072 383372011770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372011771 active site 383372011772 phosphorylation site [posttranslational modification] 383372011773 intermolecular recognition site; other site 383372011774 dimerization interface [polypeptide binding]; other site 383372011775 SAF domain; Region: SAF; cl00555 383372011776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372011777 active site 383372011778 phosphorylation site [posttranslational modification] 383372011779 intermolecular recognition site; other site 383372011780 dimerization interface [polypeptide binding]; other site 383372011781 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 383372011782 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372011783 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 383372011784 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 383372011785 ATP binding site [chemical binding]; other site 383372011786 Walker A motif; other site 383372011787 hexamer interface [polypeptide binding]; other site 383372011788 Walker B motif; other site 383372011789 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 383372011790 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 383372011791 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 383372011792 metal ion-dependent adhesion site (MIDAS); other site 383372011793 TadE-like protein; Region: TadE; cl10688 383372011794 RF-1 domain; Region: RF-1; cl02875 383372011795 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 383372011796 RF-1 domain; Region: RF-1; cl02875 383372011797 NAD-dependent deacetylase; Provisional; Region: PRK00481 383372011798 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 383372011799 LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475 383372011800 Protein of unknown function (DUF3633); Region: DUF3633; pfam12315 383372011801 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 383372011802 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 383372011803 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 383372011804 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 383372011805 Ca binding site [ion binding]; other site 383372011806 active site 383372011807 catalytic site [active] 383372011808 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 383372011809 heat shock protein 90; Provisional; Region: PRK05218 383372011810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372011811 ATP binding site [chemical binding]; other site 383372011812 Mg2+ binding site [ion binding]; other site 383372011813 G-X-G motif; other site 383372011814 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 383372011815 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 383372011816 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 383372011817 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 383372011818 Helix-turn-helix domains; Region: HTH; cl00088 383372011819 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 383372011820 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 383372011821 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 383372011822 active site 383372011823 Radical SAM superfamily; Region: Radical_SAM; pfam04055 383372011824 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 383372011825 FeS/SAM binding site; other site 383372011826 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 383372011827 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372011828 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 383372011829 Moco binding site; other site 383372011830 metal coordination site [ion binding]; other site 383372011831 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 383372011832 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 383372011833 CoA-binding site [chemical binding]; other site 383372011834 ATP-binding [chemical binding]; other site 383372011835 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 383372011836 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 383372011837 active site 383372011838 putative substrate binding pocket [chemical binding]; other site 383372011839 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 383372011840 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372011841 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372011842 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 383372011843 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 383372011844 Flavin Reductases; Region: FlaRed; cl00801 383372011845 Domain of unknown function (DUF955); Region: DUF955; cl01076 383372011846 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 383372011847 Family description; Region: UvrD_C_2; cl15862 383372011848 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 383372011849 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 383372011850 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 383372011851 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 383372011852 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 383372011853 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 383372011854 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 383372011855 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 383372011856 Peptidase family M23; Region: Peptidase_M23; pfam01551 383372011857 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 383372011858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372011859 ATP binding site [chemical binding]; other site 383372011860 Mg2+ binding site [ion binding]; other site 383372011861 G-X-G motif; other site 383372011862 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 383372011863 anchoring element; other site 383372011864 dimer interface [polypeptide binding]; other site 383372011865 ATP binding site [chemical binding]; other site 383372011866 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 383372011867 active site 383372011868 putative metal-binding site [ion binding]; other site 383372011869 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 383372011870 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 383372011871 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372011872 adenylosuccinate lyase; Provisional; Region: PRK09285 383372011873 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 383372011874 tetramer interface [polypeptide binding]; other site 383372011875 active site 383372011876 Protein of unknown function (DUF454); Region: DUF454; cl01063 383372011877 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 383372011878 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 383372011879 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 383372011880 dimer interface [polypeptide binding]; other site 383372011881 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 383372011882 putative CheW interface [polypeptide binding]; other site 383372011883 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 383372011884 putative binding surface; other site 383372011885 active site 383372011886 putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916 383372011887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372011888 ATP binding site [chemical binding]; other site 383372011889 Mg2+ binding site [ion binding]; other site 383372011890 G-X-G motif; other site 383372011891 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 383372011892 Response regulator receiver domain; Region: Response_reg; pfam00072 383372011893 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372011894 active site 383372011895 phosphorylation site [posttranslational modification] 383372011896 intermolecular recognition site; other site 383372011897 dimerization interface [polypeptide binding]; other site 383372011898 Response regulator receiver domain; Region: Response_reg; pfam00072 383372011899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372011900 active site 383372011901 phosphorylation site [posttranslational modification] 383372011902 intermolecular recognition site; other site 383372011903 dimerization interface [polypeptide binding]; other site 383372011904 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 383372011905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372011906 active site 383372011907 phosphorylation site [posttranslational modification] 383372011908 intermolecular recognition site; other site 383372011909 dimerization interface [polypeptide binding]; other site 383372011910 CheB methylesterase; Region: CheB_methylest; pfam01339 383372011911 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 383372011912 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372011913 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 383372011914 TPR repeat; Region: TPR_11; pfam13414 383372011915 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372011916 binding surface 383372011917 TPR motif; other site 383372011918 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 383372011919 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 383372011920 TPR repeat; Region: TPR_11; pfam13414 383372011921 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372011922 binding surface 383372011923 TPR motif; other site 383372011924 TPR repeat; Region: TPR_11; pfam13414 383372011925 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372011926 binding surface 383372011927 TPR motif; other site 383372011928 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372011929 binding surface 383372011930 TPR motif; other site 383372011931 TPR repeat; Region: TPR_11; pfam13414 383372011932 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372011933 binding surface 383372011934 TPR motif; other site 383372011935 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372011936 binding surface 383372011937 TPR motif; other site 383372011938 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 383372011939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372011940 ATP binding site [chemical binding]; other site 383372011941 Mg2+ binding site [ion binding]; other site 383372011942 G-X-G motif; other site 383372011943 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 383372011944 anti sigma factor interaction site; other site 383372011945 regulatory phosphorylation site [posttranslational modification]; other site 383372011946 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 383372011947 Helix-turn-helix domains; Region: HTH; cl00088 383372011948 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 383372011949 chorismate binding enzyme; Region: Chorismate_bind; cl10555 383372011950 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 383372011951 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 383372011952 dimer interface [polypeptide binding]; other site 383372011953 tetramer interface [polypeptide binding]; other site 383372011954 PYR/PP interface [polypeptide binding]; other site 383372011955 TPP binding site [chemical binding]; other site 383372011956 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 383372011957 TPP-binding site; other site 383372011958 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 383372011959 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 383372011960 substrate binding site [chemical binding]; other site 383372011961 oxyanion hole (OAH) forming residues; other site 383372011962 trimer interface [polypeptide binding]; other site 383372011963 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 383372011964 AMP-binding enzyme; Region: AMP-binding; cl15778 383372011965 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 383372011966 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such...; Region: APH_ChoK_like_1; cd05155 383372011967 Phosphotransferase enzyme family; Region: APH; pfam01636 383372011968 putative active site [active] 383372011969 putative substrate binding site [chemical binding]; other site 383372011970 ATP binding site [chemical binding]; other site 383372011971 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 383372011972 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 383372011973 DNA binding residues [nucleotide binding] 383372011974 dimerization interface [polypeptide binding]; other site 383372011975 Transposase IS200 like; Region: Y1_Tnp; cl00848 383372011976 Predicted acetyltransferase [General function prediction only]; Region: COG3153 383372011977 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 383372011978 Coenzyme A binding pocket [chemical binding]; other site 383372011979 CAAX protease self-immunity; Region: Abi; cl00558 383372011980 Cache domain; Region: Cache_1; pfam02743 383372011981 two component system sensor kinase SsrA; Provisional; Region: PRK15347 383372011982 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 383372011983 dimerization interface [polypeptide binding]; other site 383372011984 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 383372011985 Histidine kinase; Region: HisKA_3; pfam07730 383372011986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372011987 ATP binding site [chemical binding]; other site 383372011988 Mg2+ binding site [ion binding]; other site 383372011989 G-X-G motif; other site 383372011990 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 383372011991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372011992 active site 383372011993 phosphorylation site [posttranslational modification] 383372011994 intermolecular recognition site; other site 383372011995 dimerization interface [polypeptide binding]; other site 383372011996 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 383372011997 DNA binding residues [nucleotide binding] 383372011998 dimerization interface [polypeptide binding]; other site 383372011999 Response regulator receiver domain; Region: Response_reg; pfam00072 383372012000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372012001 active site 383372012002 phosphorylation site [posttranslational modification] 383372012003 intermolecular recognition site; other site 383372012004 dimerization interface [polypeptide binding]; other site 383372012005 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 383372012006 LabA_like proteins; Region: LabA_like; cd06167 383372012007 putative metal binding site [ion binding]; other site 383372012008 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 383372012009 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 383372012010 putative active site pocket [active] 383372012011 dimerization interface [polypeptide binding]; other site 383372012012 putative catalytic residue [active] 383372012013 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 383372012014 Predicted ATPase [General function prediction only]; Region: COG4637 383372012015 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372012016 Walker A/P-loop; other site 383372012017 ATP binding site [chemical binding]; other site 383372012018 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 383372012019 ABC transporter signature motif; other site 383372012020 Walker B; other site 383372012021 D-loop; other site 383372012022 H-loop/switch region; other site 383372012023 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 383372012024 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 383372012025 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09701 383372012026 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 383372012027 Predicted ATPases [General function prediction only]; Region: COG1106 383372012028 AAA domain; Region: AAA_21; pfam13304 383372012029 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 383372012030 trehalose synthase; Region: treS_nterm; TIGR02456 383372012031 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 383372012032 Ca binding site [ion binding]; other site 383372012033 active site 383372012034 catalytic site [active] 383372012035 DNA photolyase; Region: DNA_photolyase; pfam00875 383372012036 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 383372012037 putative acyl-acceptor binding pocket; other site 383372012038 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 383372012039 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; cl01792 383372012040 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 383372012041 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 383372012042 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 383372012043 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 383372012044 catalytic core [active] 383372012045 Protein of unknown function (DUF3090); Region: DUF3090; cl12832 383372012046 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 383372012047 ferredoxin-NADP+ reductase; Region: PLN02852 383372012048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372012049 Helix-turn-helix domains; Region: HTH; cl00088 383372012050 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 383372012051 Nucleoside recognition; Region: Gate; cl00486 383372012052 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 383372012053 Nucleoside recognition; Region: Gate; cl00486 383372012054 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 383372012055 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 383372012056 G1 box; other site 383372012057 GTP/Mg2+ binding site [chemical binding]; other site 383372012058 Switch I region; other site 383372012059 G2 box; other site 383372012060 G3 box; other site 383372012061 Switch II region; other site 383372012062 G4 box; other site 383372012063 FeoA domain; Region: FeoA; cl00838 383372012064 FeoA domain; Region: FeoA; cl00838 383372012065 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 383372012066 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 383372012067 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 383372012068 catalytic residue [active] 383372012069 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 383372012070 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 383372012071 Walker A/P-loop; other site 383372012072 ATP binding site [chemical binding]; other site 383372012073 Q-loop/lid; other site 383372012074 ABC transporter signature motif; other site 383372012075 Walker B; other site 383372012076 D-loop; other site 383372012077 H-loop/switch region; other site 383372012078 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 383372012079 GTPase CgtA; Reviewed; Region: obgE; PRK12297 383372012080 GTP1/OBG; Region: GTP1_OBG; pfam01018 383372012081 Obg GTPase; Region: Obg; cd01898 383372012082 G1 box; other site 383372012083 GTP/Mg2+ binding site [chemical binding]; other site 383372012084 Switch I region; other site 383372012085 G2 box; other site 383372012086 G3 box; other site 383372012087 Switch II region; other site 383372012088 G4 box; other site 383372012089 G5 box; other site 383372012090 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 383372012091 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 383372012092 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372012093 Bacterial sugar transferase; Region: Bac_transf; cl00939 383372012094 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 383372012095 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 383372012096 NAD binding site [chemical binding]; other site 383372012097 putative substrate binding site 2 [chemical binding]; other site 383372012098 putative substrate binding site 1 [chemical binding]; other site 383372012099 active site 383372012100 O-Antigen ligase; Region: Wzy_C; cl04850 383372012101 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 383372012102 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372012103 NAD(P) binding site [chemical binding]; other site 383372012104 active site 383372012105 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 383372012106 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 383372012107 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 383372012108 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 383372012109 N- and C-terminal domain interface [polypeptide binding]; other site 383372012110 putative active site [active] 383372012111 catalytic site [active] 383372012112 metal binding site [ion binding]; metal-binding site 383372012113 carbohydrate binding site [chemical binding]; other site 383372012114 ATP binding site [chemical binding]; other site 383372012115 Tetratricopeptide repeat; Region: TPR_12; pfam13424 383372012116 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 383372012117 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 383372012118 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372012119 DNA polymerase III subunit delta'; Validated; Region: PRK07940 383372012120 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 383372012121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372012122 active site 383372012123 phosphorylation site [posttranslational modification] 383372012124 intermolecular recognition site; other site 383372012125 dimerization interface [polypeptide binding]; other site 383372012126 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 383372012127 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 383372012128 dimer interface [polypeptide binding]; other site 383372012129 active site 383372012130 Bacitracin resistance protein BacA; Region: BacA; cl00858 383372012131 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 383372012132 putative active site [active] 383372012133 catalytic site [active] 383372012134 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 383372012135 PLD-like domain; Region: PLDc_2; pfam13091 383372012136 putative active site [active] 383372012137 catalytic site [active] 383372012138 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 383372012139 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 383372012140 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 383372012141 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 383372012142 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 383372012143 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 383372012144 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 383372012145 GatB domain; Region: GatB_Yqey; cl11497 383372012146 Guanylate kinase; Region: Guanylate_kin; pfam00625 383372012147 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 383372012148 catalytic site [active] 383372012149 G-X2-G-X-G-K; other site 383372012150 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 383372012151 Domain of unknown function (DUF814); Region: DUF814; pfam05670 383372012152 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 383372012153 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 383372012154 ATP-grasp domain; Region: ATP-grasp_4; cl03087 383372012155 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 383372012156 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 383372012157 carboxyltransferase (CT) interaction site; other site 383372012158 biotinylation site [posttranslational modification]; other site 383372012159 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 383372012160 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 383372012161 inhibitor site; inhibition site 383372012162 active site 383372012163 dimer interface [polypeptide binding]; other site 383372012164 catalytic residue [active] 383372012165 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372012166 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 383372012167 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 383372012168 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 383372012169 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 383372012170 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 383372012171 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 383372012172 Cysteine-rich domain; Region: CCG; pfam02754 383372012173 Cysteine-rich domain; Region: CCG; pfam02754 383372012174 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 383372012175 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 383372012176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372012177 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 383372012178 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 383372012179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372012180 active site 383372012181 phosphorylation site [posttranslational modification] 383372012182 intermolecular recognition site; other site 383372012183 dimerization interface [polypeptide binding]; other site 383372012184 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 383372012185 DNA binding site [nucleotide binding] 383372012186 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 383372012187 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 383372012188 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 383372012189 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 383372012190 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 383372012191 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 383372012192 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 383372012193 dimerization interface [polypeptide binding]; other site 383372012194 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372012195 dimer interface [polypeptide binding]; other site 383372012196 phosphorylation site [posttranslational modification] 383372012197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372012198 ATP binding site [chemical binding]; other site 383372012199 Mg2+ binding site [ion binding]; other site 383372012200 G-X-G motif; other site 383372012201 Response regulator receiver domain; Region: Response_reg; pfam00072 383372012202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372012203 active site 383372012204 phosphorylation site [posttranslational modification] 383372012205 intermolecular recognition site; other site 383372012206 dimerization interface [polypeptide binding]; other site 383372012207 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 383372012208 active site 383372012209 substrate binding site [chemical binding]; other site 383372012210 metal binding site [ion binding]; metal-binding site 383372012211 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 383372012212 UbiA prenyltransferase family; Region: UbiA; cl00337 383372012213 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 383372012214 Sulfatase; Region: Sulfatase; cl10460 383372012215 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 383372012216 Sulfatase; Region: Sulfatase; cl10460 383372012217 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 383372012218 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537 383372012219 ATP-sulfurylase; Region: ATPS; cd00517 383372012220 active site 383372012221 HXXH motif; other site 383372012222 flexible loop; other site 383372012223 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 383372012224 ligand-binding site [chemical binding]; other site 383372012225 hypothetical protein; Provisional; Region: PRK08609 383372012226 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372012227 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 383372012228 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 383372012229 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 383372012230 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 383372012231 active site 383372012232 HIGH motif; other site 383372012233 nucleotide binding site [chemical binding]; other site 383372012234 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 383372012235 KMSKS motif; other site 383372012236 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 383372012237 tRNA binding surface [nucleotide binding]; other site 383372012238 anticodon binding site; other site 383372012239 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 383372012240 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 383372012241 L11 interface [polypeptide binding]; other site 383372012242 putative EF-Tu interaction site [polypeptide binding]; other site 383372012243 putative EF-G interaction site [polypeptide binding]; other site 383372012244 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 383372012245 23S rRNA interface [nucleotide binding]; other site 383372012246 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 383372012247 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 383372012248 mRNA/rRNA interface [nucleotide binding]; other site 383372012249 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 383372012250 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 383372012251 23S rRNA interface [nucleotide binding]; other site 383372012252 L7/L12 interface [polypeptide binding]; other site 383372012253 putative thiostrepton binding site; other site 383372012254 L25 interface [polypeptide binding]; other site 383372012255 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 383372012256 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 383372012257 putative homodimer interface [polypeptide binding]; other site 383372012258 KOW motif; Region: KOW; cl00354 383372012259 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 383372012260 elongation factor Tu; Reviewed; Region: PRK00049 383372012261 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 383372012262 G1 box; other site 383372012263 GEF interaction site [polypeptide binding]; other site 383372012264 GTP/Mg2+ binding site [chemical binding]; other site 383372012265 Switch I region; other site 383372012266 G2 box; other site 383372012267 G3 box; other site 383372012268 Switch II region; other site 383372012269 G4 box; other site 383372012270 G5 box; other site 383372012271 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 383372012272 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 383372012273 Antibiotic Binding Site [chemical binding]; other site 383372012274 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 383372012275 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372012276 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 383372012277 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 383372012278 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 383372012279 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 383372012280 DNA binding residues [nucleotide binding] 383372012281 H+ Antiporter protein; Region: 2A0121; TIGR00900 383372012282 Domain of unknown function (DUF697); Region: DUF697; cl12064 383372012283 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 383372012284 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 383372012285 hinge; other site 383372012286 active site 383372012287 YGGT family; Region: YGGT; cl00508 383372012288 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372012289 dimer interface [polypeptide binding]; other site 383372012290 phosphorylation site [posttranslational modification] 383372012291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372012292 ATP binding site [chemical binding]; other site 383372012293 Mg2+ binding site [ion binding]; other site 383372012294 G-X-G motif; other site 383372012295 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 383372012296 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 383372012297 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 383372012298 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 383372012299 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 383372012300 purine monophosphate binding site [chemical binding]; other site 383372012301 dimer interface [polypeptide binding]; other site 383372012302 putative catalytic residues [active] 383372012303 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 383372012304 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 383372012305 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 383372012306 Helix-turn-helix domains; Region: HTH; cl00088 383372012307 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 383372012308 G1 box; other site 383372012309 GTP/Mg2+ binding site [chemical binding]; other site 383372012310 G2 box; other site 383372012311 Switch I region; other site 383372012312 G3 box; other site 383372012313 Switch II region; other site 383372012314 G4 box; other site 383372012315 G5 box; other site 383372012316 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 383372012317 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 383372012318 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 383372012319 putative dimer interface [polypeptide binding]; other site 383372012320 GAF domain; Region: GAF_2; pfam13185 383372012321 GAF domain; Region: GAF; cl15785 383372012322 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 383372012323 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 383372012324 putative active site [active] 383372012325 heme pocket [chemical binding]; other site 383372012326 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 383372012327 dimer interface [polypeptide binding]; other site 383372012328 phosphorylation site [posttranslational modification] 383372012329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 383372012330 ATP binding site [chemical binding]; other site 383372012331 Mg2+ binding site [ion binding]; other site 383372012332 G-X-G motif; other site 383372012333 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 383372012334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372012335 active site 383372012336 phosphorylation site [posttranslational modification] 383372012337 intermolecular recognition site; other site 383372012338 dimerization interface [polypeptide binding]; other site 383372012339 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 383372012340 DNA binding site [nucleotide binding] 383372012341 ScpA/B protein; Region: ScpA_ScpB; cl00598 383372012342 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 383372012343 aromatic arch; other site 383372012344 DCoH dimer interaction site [polypeptide binding]; other site 383372012345 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 383372012346 DCoH tetramer interaction site [polypeptide binding]; other site 383372012347 substrate binding site [chemical binding]; other site 383372012348 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 383372012349 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 383372012350 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 383372012351 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 383372012352 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 383372012353 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 383372012354 DNA binding residues [nucleotide binding] 383372012355 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 383372012356 active site 383372012357 dimer interface [polypeptide binding]; other site 383372012358 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 383372012359 SmpB-tmRNA interface; other site 383372012360 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 383372012361 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372012362 active site 383372012363 phosphorylation site [posttranslational modification] 383372012364 intermolecular recognition site; other site 383372012365 dimerization interface [polypeptide binding]; other site 383372012366 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 383372012367 DNA binding site [nucleotide binding] 383372012368 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 383372012369 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 383372012370 Walker A motif; other site 383372012371 ATP binding site [chemical binding]; other site 383372012372 Walker B motif; other site 383372012373 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 383372012374 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; pfam13366 383372012375 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 383372012376 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 383372012377 Walker A/P-loop; other site 383372012378 ATP binding site [chemical binding]; other site 383372012379 Q-loop/lid; other site 383372012380 ABC transporter signature motif; other site 383372012381 Walker B; other site 383372012382 D-loop; other site 383372012383 H-loop/switch region; other site 383372012384 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 383372012385 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 383372012386 Walker A/P-loop; other site 383372012387 ATP binding site [chemical binding]; other site 383372012388 Q-loop/lid; other site 383372012389 ABC transporter signature motif; other site 383372012390 Walker B; other site 383372012391 D-loop; other site 383372012392 H-loop/switch region; other site 383372012393 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 383372012394 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 383372012395 FtsX-like permease family; Region: FtsX; cl15850 383372012396 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 383372012397 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 383372012398 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 383372012399 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 383372012400 H+ Antiporter protein; Region: 2A0121; TIGR00900 383372012401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 383372012402 putative substrate translocation pore; other site 383372012403 serine racemase; Region: PLN02970 383372012404 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 383372012405 tetramer interface [polypeptide binding]; other site 383372012406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 383372012407 catalytic residue [active] 383372012408 cobalt transport protein CbiM; Provisional; Region: PRK07331 383372012409 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 383372012410 PDGLE domain; Region: PDGLE; cl07986 383372012411 Cobalt transport protein; Region: CbiQ; cl00463 383372012412 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 383372012413 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 383372012414 FeoA domain; Region: FeoA; cl00838 383372012415 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 383372012416 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 383372012417 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 383372012418 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 383372012419 putative PBP binding regions; other site 383372012420 ABC-ATPase subunit interface; other site 383372012421 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 383372012422 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 383372012423 putative hemin binding site; other site 383372012424 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 383372012425 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 383372012426 Walker A/P-loop; other site 383372012427 ATP binding site [chemical binding]; other site 383372012428 Q-loop/lid; other site 383372012429 ABC transporter signature motif; other site 383372012430 Walker B; other site 383372012431 D-loop; other site 383372012432 H-loop/switch region; other site 383372012433 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 383372012434 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 383372012435 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 383372012436 tetramer interface [polypeptide binding]; other site 383372012437 active site 383372012438 Mg2+/Mn2+ binding site [ion binding]; other site 383372012439 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 383372012440 malate synthase A; Region: malate_syn_A; TIGR01344 383372012441 active site 383372012442 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 383372012443 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 383372012444 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 383372012445 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 383372012446 putative molybdopterin cofactor binding site [chemical binding]; other site 383372012447 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 383372012448 molybdopterin cofactor binding site; other site 383372012449 Protein of unknown function DUF45; Region: DUF45; cl00636 383372012450 Predicted DNA-binding protein with the Helix-hairpin-helix motif [General function prediction only]; Region: COG4277 383372012451 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 383372012452 FeS/SAM binding site; other site 383372012453 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 383372012454 Helix-turn-helix domains; Region: HTH; cl00088 383372012455 HrcA protein C terminal domain; Region: HrcA; pfam01628 383372012456 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 383372012457 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 383372012458 dimer interface [polypeptide binding]; other site 383372012459 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 383372012460 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 383372012461 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 383372012462 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 383372012463 HSP70 interaction site [polypeptide binding]; other site 383372012464 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 383372012465 substrate binding site [polypeptide binding]; other site 383372012466 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 383372012467 Zn binding sites [ion binding]; other site 383372012468 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 383372012469 dimer interface [polypeptide binding]; other site 383372012470 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 383372012471 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 383372012472 integron integrase; Region: integrase_gron; TIGR02249 383372012473 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 383372012474 Int/Topo IB signature motif; other site 383372012475 active site 383372012476 DNA binding site [nucleotide binding] 383372012477 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 383372012478 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372012479 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 383372012480 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 383372012481 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 383372012482 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 383372012483 putative substrate binding site [chemical binding]; other site 383372012484 putative ATP binding site [chemical binding]; other site 383372012485 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 383372012486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 383372012487 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 383372012488 Cobalt transport protein; Region: CbiQ; cl00463 383372012489 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 383372012490 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 383372012491 Walker A/P-loop; other site 383372012492 ATP binding site [chemical binding]; other site 383372012493 Q-loop/lid; other site 383372012494 ABC transporter signature motif; other site 383372012495 Walker B; other site 383372012496 D-loop; other site 383372012497 H-loop/switch region; other site 383372012498 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 383372012499 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 383372012500 Walker A/P-loop; other site 383372012501 ATP binding site [chemical binding]; other site 383372012502 Q-loop/lid; other site 383372012503 ABC transporter signature motif; other site 383372012504 Walker B; other site 383372012505 D-loop; other site 383372012506 H-loop/switch region; other site 383372012507 TPR repeat; Region: TPR_11; pfam13414 383372012508 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372012509 binding surface 383372012510 TPR motif; other site 383372012511 TPR repeat; Region: TPR_11; pfam13414 383372012512 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 383372012513 DNA photolyase; Region: DNA_photolyase; pfam00875 383372012514 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 383372012515 LabA_like proteins; Region: LabA_like; cd06167 383372012516 putative metal binding site [ion binding]; other site 383372012517 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 383372012518 active site 383372012519 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 383372012520 putative active site [active] 383372012521 putative metal binding site [ion binding]; other site 383372012522 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 383372012523 Trm112p-like protein; Region: Trm112p; cl01066 383372012524 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 383372012525 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 383372012526 NMT1-like family; Region: NMT1_2; cl15260 383372012527 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 383372012528 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 383372012529 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 383372012530 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 383372012531 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 383372012532 Transposase domain (DUF772); Region: DUF772; cl15789 383372012533 Transposase domain (DUF772); Region: DUF772; cl15789 383372012534 Major Facilitator Superfamily; Region: MFS_1; pfam07690 383372012535 Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649 383372012536 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 383372012537 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 383372012538 active site 383372012539 catalytic tetrad [active] 383372012540 Predicted membrane protein [Function unknown]; Region: COG2311 383372012541 Protein of unknown function (DUF418); Region: DUF418; cl12135 383372012542 Protein of unknown function (DUF418); Region: DUF418; cl12135 383372012543 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 383372012544 Predicted ATPase [General function prediction only]; Region: COG3899 383372012545 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372012546 Tetratricopeptide repeat; Region: TPR_12; pfam13424 383372012547 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372012548 binding surface 383372012549 TPR motif; other site 383372012550 YceI-like domain; Region: YceI; cl01001 383372012551 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 383372012552 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 383372012553 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 383372012554 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 383372012555 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 383372012556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372012557 active site 383372012558 phosphorylation site [posttranslational modification] 383372012559 intermolecular recognition site; other site 383372012560 dimerization interface [polypeptide binding]; other site 383372012561 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 383372012562 DNA binding residues [nucleotide binding] 383372012563 dimerization interface [polypeptide binding]; other site 383372012564 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 383372012565 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 383372012566 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 383372012567 dimer interface [polypeptide binding]; other site 383372012568 active site 383372012569 catalytic nucleophile [active] 383372012570 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 383372012571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 383372012572 S-adenosylmethionine binding site [chemical binding]; other site 383372012573 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 383372012574 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 383372012575 dimer interface [polypeptide binding]; other site 383372012576 active site 383372012577 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 383372012578 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 383372012579 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 383372012580 NAD binding site [chemical binding]; other site 383372012581 substrate binding site [chemical binding]; other site 383372012582 catalytic Zn binding site [ion binding]; other site 383372012583 tetramer interface [polypeptide binding]; other site 383372012584 structural Zn binding site [ion binding]; other site 383372012585 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 383372012586 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 383372012587 Walker A/P-loop; other site 383372012588 ATP binding site [chemical binding]; other site 383372012589 Q-loop/lid; other site 383372012590 ABC transporter signature motif; other site 383372012591 Walker B; other site 383372012592 D-loop; other site 383372012593 CcmB protein; Region: CcmB; cl01016 383372012594 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 383372012595 CcmE; Region: CcmE; cl00994 383372012596 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 383372012597 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 383372012598 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 383372012599 HSP70 interaction site [polypeptide binding]; other site 383372012600 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 383372012601 TPR motif; other site 383372012602 binding surface 383372012603 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 383372012604 putative active site [active] 383372012605 homotetrameric interface [polypeptide binding]; other site 383372012606 metal binding site [ion binding]; metal-binding site 383372012607 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 383372012608 catalytic residues [active] 383372012609 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 383372012610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 383372012611 active site 383372012612 phosphorylation site [posttranslational modification] 383372012613 intermolecular recognition site; other site 383372012614 dimerization interface [polypeptide binding]; other site 383372012615 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 383372012616 DNA binding site [nucleotide binding] 383372012617 gamma-glutamyl kinase; Provisional; Region: PRK05429 383372012618 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 383372012619 nucleotide binding site [chemical binding]; other site 383372012620 homotetrameric interface [polypeptide binding]; other site 383372012621 putative phosphate binding site [ion binding]; other site 383372012622 putative allosteric binding site; other site 383372012623 PUA domain; Region: PUA; cl00607 383372012624 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 383372012625 putative catalytic cysteine [active] 383372012626 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 383372012627 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 383372012628 phosphate binding site [ion binding]; other site 383372012629 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 383372012630 GAF domain; Region: GAF_2; pfam13185 383372012631 GAF domain; Region: GAF; cl15785 383372012632 GAF domain; Region: GAF_2; pfam13185 383372012633 GAF domain; Region: GAF; cl15785 383372012634 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 383372012635 Histidine kinase; Region: HisKA_2; cl06527 383372012636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 383372012637 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 383372012638 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 383372012639 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 383372012640 active site 383372012641 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612