-- dump date   	20111121_014404
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
680646000001	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
680646000002	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
680646000003	Walker A motif; other site
680646000004	ATP binding site [chemical binding]; other site
680646000005	Walker B motif; other site
680646000006	arginine finger; other site
680646000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
680646000008	DnaA box-binding interface [nucleotide binding]; other site
680646000009	DNA polymerase III subunit beta; Validated; Region: PRK07761
680646000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140
680646000011	putative DNA binding surface [nucleotide binding]; other site
680646000012	dimer interface [polypeptide binding]; other site
680646000013	beta-clamp/clamp loader binding surface; other site
680646000014	beta-clamp/translesion DNA polymerase binding surface; other site
680646000015	recombination protein F; Reviewed; Region: recF; PRK00064
680646000016	RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage.  When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242
680646000017	Walker A/P-loop; other site
680646000018	ATP binding site [chemical binding]; other site
680646000019	Q-loop/lid; other site
680646000020	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646000021	ABC transporter signature motif; other site
680646000022	Walker B; other site
680646000023	D-loop; other site
680646000024	H-loop/switch region; other site
680646000025	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
680646000026	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
680646000027	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822
680646000028	anchoring element; other site
680646000029	dimer interface [polypeptide binding]; other site
680646000030	ATP binding site [chemical binding]; other site
680646000031	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366
680646000032	active site
680646000033	putative metal-binding site [ion binding]; other site
680646000034	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
680646000035	DNA gyrase subunit A; Validated; Region: PRK05560
680646000036	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187
680646000037	CAP-like domain; other site
680646000038	Active site [active]
680646000039	primary dimer interface [polypeptide binding]; other site
680646000040	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
680646000041	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
680646000042	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
680646000043	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
680646000044	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
680646000045	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
680646000046	Phosphate transporter family; Region: PHO4; cl00396
680646000047	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
680646000048	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
680646000049	active site
680646000050	Rhomboid family; Region: Rhomboid; cl11446
680646000051	Rhomboid family; Region: Rhomboid; cl11446
680646000052	potential protein location (hypothetical protein) that overlaps protein (shikimate 5-dehydrogenase)
680646000053	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
680646000054	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
680646000055	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
680646000056	shikimate binding site; other site
680646000057	NAD(P) binding site [chemical binding]; other site
680646000058	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976
680646000059	catalytic residues [active]
680646000060	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
680646000061	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
680646000062	GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256
680646000063	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
680646000064	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
680646000065	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
680646000066	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
680646000067	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
680646000068	active site
680646000069	motif I; other site
680646000070	motif II; other site
680646000071	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
680646000072	PTS system sorbose-specific iic component; Region: EII-Sor; cl01506
680646000073	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
680646000074	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006
680646000075	active pocket/dimerization site; other site
680646000076	active site
680646000077	phosphorylation site [posttranslational modification]
680646000078	Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four...; Region: PTS_IIB_man; cd00001
680646000079	active site
680646000080	phosphorylation site [posttranslational modification]
680646000081	transcriptional antiterminator BglG; Provisional; Region: PRK09772
680646000082	CAT RNA binding domain; Region: CAT_RBD; pfam03123
680646000083	PRD domain; Region: PRD; pfam00874
680646000084	PRD domain; Region: PRD; pfam00874
680646000085	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
680646000086	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
680646000087	active site
680646000088	phosphorylation site [posttranslational modification]
680646000089	intermolecular recognition site; other site
680646000090	dimerization interface [polypeptide binding]; other site
680646000091	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
680646000092	DNA binding site [nucleotide binding]
680646000093	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
680646000094	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
680646000095	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
680646000096	dimer interface [polypeptide binding]; other site
680646000097	phosphorylation site [posttranslational modification]
680646000098	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
680646000099	ATP binding site [chemical binding]; other site
680646000100	Mg2+ binding site [ion binding]; other site
680646000101	G-X-G motif; other site
680646000102	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
680646000103	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
680646000104	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
680646000105	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
680646000106	Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368
680646000107	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
680646000108	CrcB-like protein; Region: CRCB; cl09114
680646000109	CrcB-like protein; Region: CRCB; cl09114
680646000110	VanZ like family; Region: VanZ; cl01971
680646000111	potential protein location (hypothetical protein) that overlaps protein (glycerol uptake facilitator)
680646000112	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cd00333
680646000113	amphipathic channel; other site
680646000114	Asn-Pro-Ala signature motifs; other site
680646000115	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
680646000116	acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892
680646000117	metal binding site [ion binding]; metal-binding site
680646000118	putative dimer interface [polypeptide binding]; other site
680646000119	Flavin Reductases; Region: FlaRed; cl00801
680646000120	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
680646000121	Ligand binding site [chemical binding]; other site
680646000122	Putative Catalytic site [active]
680646000123	DXD motif; other site
680646000124	Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034
680646000125	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
680646000126	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
680646000127	metabolite-proton symporter; Region: 2A0106; TIGR00883
680646000128	putative substrate translocation pore; other site
680646000129	shikimate 5-dehydrogenase; Reviewed; Region: PRK12549
680646000130	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
680646000131	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
680646000132	shikimate binding site; other site
680646000133	NAD(P) binding site [chemical binding]; other site
680646000134	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
680646000135	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
680646000136	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
680646000137	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
680646000138	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
680646000139	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
680646000140	putative substrate binding site [chemical binding]; other site
680646000141	putative ATP binding site [chemical binding]; other site
680646000142	potential protein location (hypothetical protein) that overlaps protein (phospholipid-binding protein)
680646000143	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
680646000144	substrate binding site [chemical binding]; other site
680646000145	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
680646000146	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
680646000147	active site
680646000148	motif I; other site
680646000149	motif II; other site
680646000150	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
680646000151	Sulfate transporter family; Region: Sulfate_transp; cl00967
680646000152	Permease family; Region: Xan_ur_permease; pfam00860
680646000153	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
680646000154	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
680646000155	active site
680646000156	potential protein location (hypothetical protein) that overlaps protein (ABC-type dipeptide/oligopeptide/nickel transport system, permease component)
680646000157	Fic family protein [Function unknown]; Region: COG3177
680646000158	Fic/DOC family; Region: Fic; cl00960
680646000159	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
680646000160	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
680646000161	putative substrate translocation pore; other site
680646000162	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
680646000163	potential protein location (hypothetical protein) that overlaps protein (rhodanese-related sulfurtransferase)
680646000164	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
680646000165	active site residue [active]
680646000166	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
680646000167	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
680646000168	chorismate binding enzyme; Region: Chorismate_bind; cl10555
680646000169	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
680646000170	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
680646000171	ornithine cyclodeaminase; Validated; Region: PRK07589
680646000172	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
680646000173	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
680646000174	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
680646000175	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
680646000176	active site
680646000177	intersubunit interface [polypeptide binding]; other site
680646000178	zinc binding site [ion binding]; other site
680646000179	Na+ binding site [ion binding]; other site
680646000180	Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953
680646000181	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162
680646000182	HPr interaction site; other site
680646000183	glycerol kinase (GK) interaction site [polypeptide binding]; other site
680646000184	active site
680646000185	phosphorylation site [posttranslational modification]
680646000186	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
680646000187	active site
680646000188	catalytic site [active]
680646000189	metal binding site [ion binding]; metal-binding site
680646000190	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
680646000191	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
680646000192	tetramerization interface [polypeptide binding]; other site
680646000193	NAD(P) binding site [chemical binding]; other site
680646000194	catalytic residues [active]
680646000195	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
680646000196	putative dimer interface [polypeptide binding]; other site
680646000197	putative [2Fe-2S] cluster binding site [ion binding]; other site
680646000198	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
680646000199	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
680646000200	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
680646000201	RNA binding surface [nucleotide binding]; other site
680646000202	putative efflux protein, MATE family; Region: matE; TIGR00797
680646000203	MatE; Region: MatE; pfam01554
680646000204	MatE; Region: MatE; pfam01554
680646000205	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
680646000206	dimer interface [polypeptide binding]; other site
680646000207	FMN binding site [chemical binding]; other site
680646000208	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
680646000209	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
680646000210	metal-binding site [ion binding]
680646000211	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
680646000212	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
680646000213	potential protein location (hypothetical protein) that overlaps protein (asparagine synthase)
680646000214	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
680646000215	putative homotetramer interface [polypeptide binding]; other site
680646000216	putative homodimer interface [polypeptide binding]; other site
680646000217	putative allosteric switch controlling residues; other site
680646000218	putative metal binding site [ion binding]; other site
680646000219	putative homodimer-homodimer interface [polypeptide binding]; other site
680646000220	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
680646000221	putative active site [active]
680646000222	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
680646000223	putative active site [active]
680646000224	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
680646000225	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
680646000226	cofactor binding site; other site
680646000227	DNA binding site [nucleotide binding]
680646000228	substrate interaction site [chemical binding]; other site
680646000229	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
680646000230	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440
680646000231	phosphate acetyltransferase; Reviewed; Region: PRK05632
680646000232	DRTGG domain; Region: DRTGG; cl12147
680646000233	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
680646000234	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
680646000235	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
680646000236	prephenate dehydratase; Provisional; Region: PRK11898
680646000237	Prephenate dehydratase; Region: PDT; pfam00800
680646000238	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
680646000239	putative L-Phe binding site [chemical binding]; other site
680646000240	seryl-tRNA synthetase; Provisional; Region: PRK05431
680646000241	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
680646000242	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
680646000243	dimer interface [polypeptide binding]; other site
680646000244	active site
680646000245	motif 1; other site
680646000246	motif 2; other site
680646000247	motif 3; other site
680646000248	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
680646000249	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
680646000250	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
680646000251	Fic/DOC family; Region: Fic; cl00960
680646000252	potential protein location (hypothetical protein) that overlaps protein (Rhs family protein)
680646000253	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646000254	Fic/DOC family; Region: Fic; cl00960
680646000255	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646000256	ABC transporter signature motif; other site
680646000257	Walker B; other site
680646000258	D-loop; other site
680646000259	The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export.  They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins.  The ABCC subfamily contains transporters with...; Region: ABCC_MRP_Like; cd03228
680646000260	Walker A/P-loop; other site
680646000261	ATP binding site [chemical binding]; other site
680646000262	ABC transporter signature motif; other site
680646000263	Walker B; other site
680646000264	D-loop; other site
680646000265	H-loop/switch region; other site
680646000266	Acetokinase family; Region: Acetate_kinase; cl01029
680646000267	Peptidase family M48; Region: Peptidase_M48; cl12018
680646000268	Membrane transport protein; Region: Mem_trans; cl09117
680646000269	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
680646000270	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
680646000271	S-layer homology domain; Region: SLH; pfam00395
680646000272	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
680646000273	putative phosphate binding site [ion binding]; other site
680646000274	putative catalytic site [active]
680646000275	active site
680646000276	metal binding site A [ion binding]; metal-binding site
680646000277	DNA binding site [nucleotide binding]
680646000278	putative AP binding site [nucleotide binding]; other site
680646000279	putative metal binding site B [ion binding]; other site
680646000280	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
680646000281	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
680646000282	metal binding site [ion binding]; metal-binding site
680646000283	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
680646000284	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235
680646000285	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
680646000286	ABC-ATPase subunit  interface; other site
680646000287	dimer interface [polypeptide binding]; other site
680646000288	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
680646000289	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
680646000290	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
680646000291	FeoA domain; Region: FeoA; cl00838
680646000292	H+ Antiporter protein; Region: 2A0121; TIGR00900
680646000293	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
680646000294	putative substrate translocation pore; other site
680646000295	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757
680646000296	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
680646000297	ATP binding site [chemical binding]; other site
680646000298	substrate interface [chemical binding]; other site
680646000299	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
680646000300	Beta-lactamase; Region: Beta-lactamase; cl01009
680646000301	PBP4 family; Region: PBP4; TIGR00666
680646000302	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
680646000303	dimer interface [polypeptide binding]; other site
680646000304	substrate binding site [chemical binding]; other site
680646000305	metal binding sites [ion binding]; metal-binding site
680646000306	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
680646000307	Ligand Binding Site [chemical binding]; other site
680646000308	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
680646000309	FtsH Extracellular; Region: FtsH_ext; pfam06480
680646000310	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
680646000311	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
680646000312	Walker A motif; other site
680646000313	ATP binding site [chemical binding]; other site
680646000314	Walker B motif; other site
680646000315	arginine finger; other site
680646000316	Peptidase family M41; Region: Peptidase_M41; pfam01434
680646000317	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
680646000318	homodecamer interface [polypeptide binding]; other site
680646000319	GTP cyclohydrolase I; Provisional; Region: PLN03044
680646000320	active site
680646000321	putative catalytic site residues [active]
680646000322	zinc binding site [ion binding]; other site
680646000323	GTP-CH-I/GFRP interaction surface; other site
680646000324	Abi-like protein; Region: Abi_2; cl01988
680646000325	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
680646000326	dihydropteroate synthase; Region: DHPS; TIGR01496
680646000327	substrate binding pocket [chemical binding]; other site
680646000328	dimer interface [polypeptide binding]; other site
680646000329	inhibitor binding site; inhibition site
680646000330	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines...; Region: DHNA_DHNTPE; cd00534
680646000331	homooctamer interface [polypeptide binding]; other site
680646000332	active site
680646000333	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
680646000334	catalytic center binding site [active]
680646000335	ATP binding site [chemical binding]; other site
680646000336	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
680646000337	Bacterial membrane flanked domain; Region: DUF304; cl01348
680646000338	Predicted membrane protein [Function unknown]; Region: COG3428
680646000339	Bacterial membrane flanked domain; Region: DUF304; cl01348
680646000340	Predicted membrane protein [Function unknown]; Region: COG3428
680646000341	Bacterial membrane flanked domain; Region: DUF304; cl01348
680646000342	Bacterial membrane flanked domain; Region: DUF304; cl01348
680646000343	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
680646000344	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
680646000345	Pantoate-beta-alanine ligase; Region: PanC; cd00560
680646000346	pantoate--beta-alanine ligase; Region: panC; TIGR00018
680646000347	active site
680646000348	ATP-binding site [chemical binding]; other site
680646000349	pantoate-binding site; other site
680646000350	HXXH motif; other site
680646000351	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
680646000352	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322
680646000353	putative anticodon binding site; other site
680646000354	dimer interface [polypeptide binding]; other site
680646000355	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
680646000356	motif 1; other site
680646000357	dimer interface [polypeptide binding]; other site
680646000358	active site
680646000359	motif 2; other site
680646000360	motif 3; other site
680646000361	Lsr2; Region: Lsr2; pfam11774
680646000362	Clp protease ATP binding subunit; Region: clpC; CHL00095
680646000363	Clp amino terminal domain; Region: Clp_N; pfam02861
680646000364	Clp amino terminal domain; Region: Clp_N; pfam02861
680646000365	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
680646000366	Walker A motif; other site
680646000367	ATP binding site [chemical binding]; other site
680646000368	Walker B motif; other site
680646000369	arginine finger; other site
680646000370	UvrB/uvrC motif; Region: UVR; pfam02151
680646000371	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
680646000372	Walker A motif; other site
680646000373	ATP binding site [chemical binding]; other site
680646000374	Walker B motif; other site
680646000375	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
680646000376	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
680646000377	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
680646000378	minor groove reading motif; other site
680646000379	helix-hairpin-helix signature motif; other site
680646000380	active site
680646000381	FES domain; Region: FES; smart00525
680646000382	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
680646000383	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
680646000384	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
680646000385	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
680646000386	DNA repair protein RadA; Provisional; Region: PRK11823
680646000387	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646000388	Walker A motif; other site
680646000389	ATP binding site [chemical binding]; other site
680646000390	Walker B motif; other site
680646000391	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
680646000392	Predicted membrane protein [Function unknown]; Region: COG4129
680646000393	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156
680646000394	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
680646000395	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
680646000396	active site
680646000397	Phosphate transporter family; Region: PHO4; cl00396
680646000398	Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one  highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216
680646000399	active site/substrate binding site [active]
680646000400	tetramer interface [polypeptide binding]; other site
680646000401	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756
680646000402	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
680646000403	DEAD-like helicases superfamily; Region: DEXDc; smart00487
680646000404	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
680646000405	ATP binding site [chemical binding]; other site
680646000406	putative Mg++ binding site [ion binding]; other site
680646000407	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
680646000408	nucleotide binding region [chemical binding]; other site
680646000409	ATP-binding site [chemical binding]; other site
680646000410	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
680646000411	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
680646000412	nucleoside/Zn binding site; other site
680646000413	dimer interface [polypeptide binding]; other site
680646000414	catalytic motif [active]
680646000415	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646000416	Walker A/P-loop; other site
680646000417	ATP binding site [chemical binding]; other site
680646000418	Q-loop/lid; other site
680646000419	ABC transporter signature motif; other site
680646000420	Walker B; other site
680646000421	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
680646000422	Predicted membrane protein [Function unknown]; Region: COG1511
680646000423	Predicted membrane protein [Function unknown]; Region: COG1511
680646000424	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
680646000425	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
680646000426	ABC-2 type transporter; Region: ABC2_membrane; cl11417
680646000427	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
680646000428	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
680646000429	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
680646000430	potential protein location (hypothetical protein RMDY18_01940 [Rothia mucilaginosa DY-18]) that overlaps RNA (tRNA-S)
680646000431	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
680646000432	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
680646000433	DNA binding site [nucleotide binding]
680646000434	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
680646000435	catalytic core [active]
680646000436	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
680646000437	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
680646000438	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
680646000439	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
680646000440	NAD(P) binding site [chemical binding]; other site
680646000441	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
680646000442	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
680646000443	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
680646000444	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
680646000445	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
680646000446	adenylosuccinate lyase; Provisional; Region: PRK09285
680646000447	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
680646000448	tetramer interface [polypeptide binding]; other site
680646000449	active site
680646000450	chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086
680646000451	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
680646000452	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
680646000453	pyridoxal 5'-phosphate binding site [chemical binding]; other site
680646000454	homodimer interface [polypeptide binding]; other site
680646000455	catalytic residue [active]
680646000456	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
680646000457	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
680646000458	tetramer interface [polypeptide binding]; other site
680646000459	TPP-binding site [chemical binding]; other site
680646000460	heterodimer interface [polypeptide binding]; other site
680646000461	phosphorylation loop region [posttranslational modification]
680646000462	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
680646000463	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
680646000464	alpha subunit interface [polypeptide binding]; other site
680646000465	TPP binding site [chemical binding]; other site
680646000466	heterodimer interface [polypeptide binding]; other site
680646000467	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
680646000468	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
680646000469	E3 interaction surface; other site
680646000470	lipoyl attachment site [posttranslational modification]; other site
680646000471	e3 binding domain; Region: E3_binding; pfam02817
680646000472	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
680646000473	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
680646000474	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
680646000475	maltose O-acetyltransferase; Provisional; Region: PRK10092
680646000476	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
680646000477	trimer interface [polypeptide binding]; other site
680646000478	active site
680646000479	substrate binding site [chemical binding]; other site
680646000480	CoA binding site [chemical binding]; other site
680646000481	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605
680646000482	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
680646000483	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
680646000484	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
680646000485	MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport.  Other members of this system include the MetP permease and  the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258
680646000486	Walker A/P-loop; other site
680646000487	ATP binding site [chemical binding]; other site
680646000488	Q-loop/lid; other site
680646000489	ABC transporter signature motif; other site
680646000490	Walker B; other site
680646000491	D-loop; other site
680646000492	H-loop/switch region; other site
680646000493	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
680646000494	dimer interface [polypeptide binding]; other site
680646000495	conserved gate region; other site
680646000496	putative PBP binding loops; other site
680646000497	ABC-ATPase subunit interface; other site
680646000498	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
680646000499	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
680646000500	motif II; other site
680646000501	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
680646000502	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
680646000503	Walker A/P-loop; other site
680646000504	ATP binding site [chemical binding]; other site
680646000505	Q-loop/lid; other site
680646000506	ABC transporter signature motif; other site
680646000507	Walker B; other site
680646000508	D-loop; other site
680646000509	H-loop/switch region; other site
680646000510	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
680646000511	catalytic core [active]
680646000512	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
680646000513	catalytic core [active]
680646000514	VanZ like family; Region: VanZ; cl01971
680646000515	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
680646000516	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
680646000517	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
680646000518	potential protein location (hypothetical protein) that overlaps protein (fructose-1-phosphate kinase)
680646000519	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
680646000520	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
680646000521	putative substrate binding site [chemical binding]; other site
680646000522	putative ATP binding site [chemical binding]; other site
680646000523	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
680646000524	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
680646000525	active site
680646000526	phosphorylation site [posttranslational modification]
680646000527	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569
680646000528	P-loop; other site
680646000529	active site
680646000530	phosphorylation site [posttranslational modification]
680646000531	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
680646000532	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
680646000533	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
680646000534	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
680646000535	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
680646000536	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
680646000537	dimerization domain swap beta strand [polypeptide binding]; other site
680646000538	regulatory protein interface [polypeptide binding]; other site
680646000539	active site
680646000540	regulatory phosphorylation site [posttranslational modification]; other site
680646000541	Uncharacterized conserved protein [Function unknown]; Region: COG2966
680646000542	Protein of unknown function (DUF1212); Region: DUF1212; cl01118
680646000543	Protein of unknown function (DUF1212); Region: DUF1212; cl01118
680646000544	Uracil DNA glycosylase superfamily; Region: UDG; cl00483
680646000545	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
680646000546	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
680646000547	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
680646000548	ring oligomerisation interface [polypeptide binding]; other site
680646000549	ATP/Mg binding site [chemical binding]; other site
680646000550	stacking interactions; other site
680646000551	hinge regions; other site
680646000552	23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522
680646000553	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
680646000554	S-adenosylmethionine binding site [chemical binding]; other site
680646000555	H+ Antiporter protein; Region: 2A0121; TIGR00900
680646000556	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
680646000557	DinB superfamily; Region: DinB_2; cl00986
680646000558	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
680646000559	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
680646000560	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
680646000561	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
680646000562	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
680646000563	Isochorismatase family; Region: Isochorismatase; pfam00857
680646000564	catalytic triad [active]
680646000565	conserved cis-peptide bond; other site
680646000566	potential protein location (hypothetical protein) that overlaps protein (dehydrogenase)
680646000567	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
680646000568	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
680646000569	NAD(P) binding site [chemical binding]; other site
680646000570	active site
680646000571	isochorismate synthase DhbC; Validated; Region: PRK06923
680646000572	chorismate binding enzyme; Region: Chorismate_bind; cl10555
680646000573	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
680646000574	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
680646000575	RNA/DNA hybrid binding site [nucleotide binding]; other site
680646000576	active site
680646000577	Proteins of 100 residues with WXG; Region: WXG100; cl02005
680646000578	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
680646000579	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
680646000580	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
680646000581	dimer interface [polypeptide binding]; other site
680646000582	phosphorylation site [posttranslational modification]
680646000583	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
680646000584	ATP binding site [chemical binding]; other site
680646000585	Mg2+ binding site [ion binding]; other site
680646000586	G-X-G motif; other site
680646000587	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
680646000588	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
680646000589	active site
680646000590	phosphorylation site [posttranslational modification]
680646000591	intermolecular recognition site; other site
680646000592	dimerization interface [polypeptide binding]; other site
680646000593	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
680646000594	DNA binding site [nucleotide binding]
680646000595	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
680646000596	potential protein location (hypothetical protein) that overlaps protein (acyl-CoA dehydrogenase)
680646000597	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
680646000598	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
680646000599	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
680646000600	FeoA domain; Region: FeoA; cl00838
680646000601	NlpC/P60 family; Region: NLPC_P60; cl11438
680646000602	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
680646000603	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
680646000604	UvrD/REP helicase; Region: UvrD-helicase; cl14126
680646000605	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
680646000606	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
680646000607	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
680646000608	CoA-ligase; Region: Ligase_CoA; pfam00549
680646000609	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
680646000610	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
680646000611	CoA-ligase; Region: Ligase_CoA; pfam00549
680646000612	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
680646000613	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
680646000614	diiron binding motif [ion binding]; other site
680646000615	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
680646000616	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
680646000617	dimerization interface [polypeptide binding]; other site
680646000618	DPS ferroxidase diiron center [ion binding]; other site
680646000619	ion pore; other site
680646000620	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
680646000621	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
680646000622	motif II; other site
680646000623	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
680646000624	NAD(P) binding site [chemical binding]; other site
680646000625	active site
680646000626	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
680646000627	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
680646000628	Walker A motif; other site
680646000629	ATP binding site [chemical binding]; other site
680646000630	Walker B motif; other site
680646000631	arginine finger; other site
680646000632	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
680646000633	Walker A motif; other site
680646000634	ATP binding site [chemical binding]; other site
680646000635	Walker B motif; other site
680646000636	arginine finger; other site
680646000637	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
680646000638	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195
680646000639	Excalibur calcium-binding domain; Region: Excalibur; pfam05901
680646000640	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
680646000641	putative metal binding residues [ion binding]; other site
680646000642	signature motif; other site
680646000643	dimer interface [polypeptide binding]; other site
680646000644	polyP binding site; other site
680646000645	active site
680646000646	substrate binding site [chemical binding]; other site
680646000647	acceptor-phosphate pocket; other site
680646000648	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
680646000649	Predicted periplasmic protein (DUF2233); Region: DUF2233; cl10481
680646000650	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
680646000651	Ligand binding site [chemical binding]; other site
680646000652	Putative Catalytic site [active]
680646000653	DXD motif; other site
680646000654	GtrA-like protein; Region: GtrA; cl00971
680646000655	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
680646000656	active site
680646000657	catalytic triad [active]
680646000658	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
680646000659	active site
680646000660	catalytic triad [active]
680646000661	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
680646000662	active site
680646000663	catalytic triad [active]
680646000664	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
680646000665	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196
680646000666	dimerization interface [polypeptide binding]; other site
680646000667	putative ATP binding site [chemical binding]; other site
680646000668	amidophosphoribosyltransferase; Provisional; Region: PRK07847
680646000669	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
680646000670	active site
680646000671	tetramer interface [polypeptide binding]; other site
680646000672	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
680646000673	L-asparaginase II; Region: Asparaginase_II; cl01842
680646000674	PQ loop repeat; Region: PQ-loop; cl12056
680646000675	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
680646000676	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
680646000677	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
680646000678	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
680646000679	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
680646000680	ATP binding site [chemical binding]; other site
680646000681	active site
680646000682	substrate binding site [chemical binding]; other site
680646000683	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
680646000684	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
680646000685	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
680646000686	Walker A/P-loop; other site
680646000687	ATP binding site [chemical binding]; other site
680646000688	Q-loop/lid; other site
680646000689	ABC transporter signature motif; other site
680646000690	Walker B; other site
680646000691	D-loop; other site
680646000692	H-loop/switch region; other site
680646000693	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
680646000694	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
680646000695	FtsX-like permease family; Region: FtsX; pfam02687
680646000696	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
680646000697	DNA-binding site [nucleotide binding]; DNA binding site
680646000698	FCD domain; Region: FCD; cl11656
680646000699	glycolate transporter; Provisional; Region: PRK09695
680646000700	L-lactate permease; Region: Lactate_perm; cl00701
680646000701	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
680646000702	Cysteine-rich domain; Region: CCG; pfam02754
680646000703	Cysteine-rich domain; Region: CCG; pfam02754
680646000704	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
680646000705	Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674
680646000706	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
680646000707	Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674
680646000708	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859
680646000709	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
680646000710	Moco binding site; other site
680646000711	metal coordination site [ion binding]; other site
680646000712	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
680646000713	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
680646000714	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
680646000715	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646000716	Walker A/P-loop; other site
680646000717	ATP binding site [chemical binding]; other site
680646000718	Q-loop/lid; other site
680646000719	ABC transporter signature motif; other site
680646000720	Walker B; other site
680646000721	D-loop; other site
680646000722	H-loop/switch region; other site
680646000723	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
680646000724	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
680646000725	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646000726	Walker A/P-loop; other site
680646000727	ATP binding site [chemical binding]; other site
680646000728	Q-loop/lid; other site
680646000729	ABC transporter signature motif; other site
680646000730	Walker B; other site
680646000731	D-loop; other site
680646000732	H-loop/switch region; other site
680646000733	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
680646000734	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
680646000735	active site
680646000736	metal binding site [ion binding]; metal-binding site
680646000737	Transglycosylase; Region: Transgly; cl07896
680646000738	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
680646000739	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
680646000740	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
680646000741	homotrimer interaction site [polypeptide binding]; other site
680646000742	putative active site [active]
680646000743	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447
680646000744	nudix motif; other site
680646000745	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
680646000746	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
680646000747	ligand binding site [chemical binding]; other site
680646000748	flexible hinge region; other site
680646000749	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
680646000750	Colicin V production protein; Region: Colicin_V; cl00567
680646000751	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149
680646000752	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
680646000753	trimer interface [polypeptide binding]; other site
680646000754	active site
680646000755	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
680646000756	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
680646000757	minor groove reading motif; other site
680646000758	helix-hairpin-helix signature motif; other site
680646000759	substrate binding pocket [chemical binding]; other site
680646000760	active site
680646000761	FES domain; Region: FES; smart00525
680646000762	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
680646000763	putative active site [active]
680646000764	putative CoA binding site [chemical binding]; other site
680646000765	nudix motif; other site
680646000766	metal binding site [ion binding]; metal-binding site
680646000767	bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975
680646000768	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444
680646000769	active site
680646000770	DNA binding site [nucleotide binding]
680646000771	catalytic site [active]
680646000772	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
680646000773	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646000774	Walker A motif; other site
680646000775	ATP binding site [chemical binding]; other site
680646000776	Walker B motif; other site
680646000777	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
680646000778	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
680646000779	ATP binding site [chemical binding]; other site
680646000780	putative Mg++ binding site [ion binding]; other site
680646000781	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
680646000782	nucleotide binding region [chemical binding]; other site
680646000783	ATP-binding site [chemical binding]; other site
680646000784	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
680646000785	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
680646000786	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
680646000787	active site residue [active]
680646000788	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368
680646000789	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
680646000790	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
680646000791	Cation efflux family; Region: Cation_efflux; cl00316
680646000792	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
680646000793	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
680646000794	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
680646000795	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363
680646000796	active site
680646000797	interdomain interaction site; other site
680646000798	putative metal-binding site [ion binding]; other site
680646000799	nucleotide binding site [chemical binding]; other site
680646000800	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cl11986
680646000801	domain I; other site
680646000802	phosphate binding site [ion binding]; other site
680646000803	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186
680646000804	domain II; other site
680646000805	domain III; other site
680646000806	nucleotide binding site [chemical binding]; other site
680646000807	DNA binding groove [nucleotide binding]
680646000808	catalytic site [active]
680646000809	domain IV; other site
680646000810	exopolyphosphatase; Region: exo_poly_only; TIGR03706
680646000811	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
680646000812	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
680646000813	Cl- selectivity filter; other site
680646000814	Cl- binding residues [ion binding]; other site
680646000815	pore gating glutamate residue; other site
680646000816	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
680646000817	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
680646000818	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
680646000819	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
680646000820	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
680646000821	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
680646000822	Cation transport protein; Region: TrkH; cl10514
680646000823	potential protein location (hypothetical protein) that overlaps protein (predicted transcriptional regulator)
680646000824	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
680646000825	dimerization interface [polypeptide binding]; other site
680646000826	putative DNA binding site [nucleotide binding]; other site
680646000827	putative Zn2+ binding site [ion binding]; other site
680646000828	Transcriptional regulators [Transcription]; Region: GntR; COG1802
680646000829	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
680646000830	FCD domain; Region: FCD; cl11656
680646000831	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
680646000832	catalytic core [active]
680646000833	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
680646000834	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; COG1575
680646000835	UbiA prenyltransferase family; Region: UbiA; cl00337
680646000836	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
680646000837	naphthoate synthase; Validated; Region: PRK08321
680646000838	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558
680646000839	substrate binding site [chemical binding]; other site
680646000840	oxyanion hole (OAH) forming residues; other site
680646000841	trimer interface [polypeptide binding]; other site
680646000842	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
680646000843	Sodium:solute symporter family; Region: SSF; cl00456
680646000844	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
680646000845	active site
680646000846	HIGH motif; other site
680646000847	nucleotide binding site [chemical binding]; other site
680646000848	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
680646000849	active site
680646000850	KMSKS motif; other site
680646000851	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
680646000852	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173
680646000853	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
680646000854	dimer interface [polypeptide binding]; other site
680646000855	tetramer interface [polypeptide binding]; other site
680646000856	PYR/PP interface [polypeptide binding]; other site
680646000857	TPP binding site [chemical binding]; other site
680646000858	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629
680646000859	TPP-binding site [chemical binding]; other site
680646000860	O-succinylbenzoate synthase; Provisional; Region: PRK02901
680646000861	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway...; Region: OSBS; cd03320
680646000862	active site
680646000863	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
680646000864	active site
680646000865	Cupin domain; Region: Cupin_2; cl09118
680646000866	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
680646000867	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
680646000868	NADP binding site [chemical binding]; other site
680646000869	active site
680646000870	steroid binding site; other site
680646000871	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
680646000872	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262
680646000873	Walker A/P-loop; other site
680646000874	ATP binding site [chemical binding]; other site
680646000875	Q-loop/lid; other site
680646000876	ABC transporter signature motif; other site
680646000877	Walker B; other site
680646000878	D-loop; other site
680646000879	H-loop/switch region; other site
680646000880	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
680646000881	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
680646000882	dimer interface [polypeptide binding]; other site
680646000883	conserved gate region; other site
680646000884	putative PBP binding loops; other site
680646000885	ABC-ATPase subunit interface; other site
680646000886	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
680646000887	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
680646000888	substrate binding pocket [chemical binding]; other site
680646000889	membrane-bound complex binding site; other site
680646000890	hinge residues; other site
680646000891	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
680646000892	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
680646000893	S-adenosylmethionine binding site [chemical binding]; other site
680646000894	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
680646000895	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
680646000896	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
680646000897	substrate binding pocket [chemical binding]; other site
680646000898	chain length determination region; other site
680646000899	substrate-Mg2+ binding site; other site
680646000900	catalytic residues [active]
680646000901	aspartate-rich region 1; other site
680646000902	active site lid residues [active]
680646000903	aspartate-rich region 2; other site
680646000904	Sodium:neurotransmitter symporter family; Region: SNF; cl11976
680646000905	Predicted permeases [General function prediction only]; Region: RarD; COG2962
680646000906	EamA-like transporter family; Region: EamA; cl01037
680646000907	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
680646000908	metal binding site 2 [ion binding]; metal-binding site
680646000909	putative DNA binding helix; other site
680646000910	metal binding site 1 [ion binding]; metal-binding site
680646000911	dimer interface [polypeptide binding]; other site
680646000912	structural Zn2+ binding site [ion binding]; other site
680646000913	potential protein location (hypothetical protein) that overlaps protein (predicted hydrolase of the HD superfamily)
680646000914	Peptidase family M48; Region: Peptidase_M48; cl12018
680646000915	Protein of unknown function (DUF520); Region: DUF520; cl00723
680646000916	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
680646000917	catalytic residues [active]
680646000918	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
680646000919	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
680646000920	Predicted membrane protein (DUF2079); Region: DUF2079; cl01374
680646000921	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
680646000922	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif (...; Region: DEADc; cd00268
680646000923	ATP binding site [chemical binding]; other site
680646000924	Mg++ binding site [ion binding]; other site
680646000925	motif III; other site
680646000926	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
680646000927	nucleotide binding region [chemical binding]; other site
680646000928	ATP-binding site [chemical binding]; other site
680646000929	DbpA RNA binding domain; Region: DbpA; pfam03880
680646000930	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
680646000931	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
680646000932	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
680646000933	active site
680646000934	catalytic site [active]
680646000935	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
680646000936	active site
680646000937	catalytic site [active]
680646000938	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
680646000939	FAD binding domain; Region: FAD_binding_4; pfam01565
680646000940	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
680646000941	benzoate transport; Region: 2A0115; TIGR00895
680646000942	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
680646000943	putative substrate translocation pore; other site
680646000944	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
680646000945	Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870
680646000946	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
680646000947	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
680646000948	Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774
680646000949	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209
680646000950	folate binding site [chemical binding]; other site
680646000951	NADP+ binding site [chemical binding]; other site
680646000952	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
680646000953	dimerization interface [polypeptide binding]; other site
680646000954	active site
680646000955	potential protein location (hypothetical protein) that overlaps protein (NTP pyrophosphohydrolase including oxidative damage repair enzyme)
680646000956	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
680646000957	active site
680646000958	Ap6A binding site [chemical binding]; other site
680646000959	nudix motif; other site
680646000960	metal binding site [ion binding]; metal-binding site
680646000961	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
680646000962	catalytic core [active]
680646000963	polyphosphate kinase; Provisional; Region: PRK05443
680646000964	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
680646000965	putative domain interface [polypeptide binding]; other site
680646000966	putative active site [active]
680646000967	catalytic site [active]
680646000968	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
680646000969	putative domain interface [polypeptide binding]; other site
680646000970	putative active site [active]
680646000971	catalytic site [active]
680646000972	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
680646000973	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
680646000974	Coenzyme A binding pocket [chemical binding]; other site
680646000975	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
680646000976	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
680646000977	DNA binding site [nucleotide binding]
680646000978	potential protein location (hypothetical protein) that overlaps protein (response regulator consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain)
680646000979	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
680646000980	heme-binding site [chemical binding]; other site
680646000981	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
680646000982	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
680646000983	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
680646000984	potential protein location (hypothetical protein) that overlaps protein (6-phosphofructokinase)
680646000985	6-phosphofructokinase; Provisional; Region: PRK03202
680646000986	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204
680646000987	active site
680646000988	ADP/pyrophosphate binding site [chemical binding]; other site
680646000989	dimerization interface [polypeptide binding]; other site
680646000990	allosteric effector site; other site
680646000991	fructose-1,6-bisphosphate binding site; other site
680646000992	aspartate aminotransferase; Provisional; Region: PRK08361
680646000993	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
680646000994	pyridoxal 5'-phosphate binding site [chemical binding]; other site
680646000995	homodimer interface [polypeptide binding]; other site
680646000996	catalytic residue [active]
680646000997	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
680646000998	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
680646000999	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
680646001000	putative homodimer interface [polypeptide binding]; other site
680646001001	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
680646001002	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
680646001003	23S rRNA interface [nucleotide binding]; other site
680646001004	L7/L12 interface [polypeptide binding]; other site
680646001005	putative thiostrepton binding site; other site
680646001006	L25 interface [polypeptide binding]; other site
680646001007	potential protein location (hypothetical protein) that overlaps protein (ribosomal protein L1)
680646001008	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403
680646001009	mRNA/rRNA interface [nucleotide binding]; other site
680646001010	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324
680646001011	gating phenylalanine in ion channel; other site
680646001012	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
680646001013	ABC Carbohydrate and Solute Transporters-like subgroup.  This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols.  ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259
680646001014	Walker A/P-loop; other site
680646001015	ATP binding site [chemical binding]; other site
680646001016	Q-loop/lid; other site
680646001017	ABC transporter signature motif; other site
680646001018	Walker B; other site
680646001019	D-loop; other site
680646001020	H-loop/switch region; other site
680646001021	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797
680646001022	23S rRNA interface [nucleotide binding]; other site
680646001023	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
680646001024	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
680646001025	core dimer interface [polypeptide binding]; other site
680646001026	peripheral dimer interface [polypeptide binding]; other site
680646001027	L10 interface [polypeptide binding]; other site
680646001028	L11 interface [polypeptide binding]; other site
680646001029	putative EF-Tu interaction site [polypeptide binding]; other site
680646001030	putative EF-G interaction site [polypeptide binding]; other site
680646001031	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
680646001032	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
680646001033	substrate binding [chemical binding]; other site
680646001034	active site
680646001035	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
680646001036	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212
680646001037	active site turn [active]
680646001038	phosphorylation site [posttranslational modification]
680646001039	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
680646001040	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162
680646001041	HPr interaction site; other site
680646001042	glycerol kinase (GK) interaction site [polypeptide binding]; other site
680646001043	active site
680646001044	phosphorylation site [posttranslational modification]
680646001045	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
680646001046	Transcriptional regulators [Transcription]; Region: PurR; COG1609
680646001047	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
680646001048	DNA binding site [nucleotide binding]
680646001049	domain linker motif; other site
680646001050	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
680646001051	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
680646001052	dimer interface [polypeptide binding]; other site
680646001053	putative functional site; other site
680646001054	putative MPT binding site; other site
680646001055	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
680646001056	GTP binding site [chemical binding]; other site
680646001057	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
680646001058	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
680646001059	FeS/SAM binding site; other site
680646001060	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
680646001061	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
680646001062	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
680646001063	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
680646001064	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
680646001065	dimer interface [polypeptide binding]; other site
680646001066	putative functional site; other site
680646001067	putative MPT binding site; other site
680646001068	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420
680646001069	trimer interface [polypeptide binding]; other site
680646001070	dimer interface [polypeptide binding]; other site
680646001071	putative active site [active]
680646001072	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886
680646001073	MPT binding site; other site
680646001074	trimer interface [polypeptide binding]; other site
680646001075	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
680646001076	MoaE homodimer interface [polypeptide binding]; other site
680646001077	MoaD interaction [polypeptide binding]; other site
680646001078	active site residues [active]
680646001079	molybdopterin biosynthesis protein MoeB; Validated; Region: PRK05597
680646001080	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757
680646001081	ATP binding site [chemical binding]; other site
680646001082	substrate interface [chemical binding]; other site
680646001083	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
680646001084	active site residue [active]
680646001085	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
680646001086	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate...; Region: MopB_Nitrate-R-NarG-like; cd02750
680646001087	[4Fe-4S] binding site [ion binding]; other site
680646001088	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928
680646001089	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928
680646001090	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928
680646001091	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
680646001092	molybdopterin cofactor binding site; other site
680646001093	potential protein location (hypothetical protein) that overlaps protein (nitrate reductase delta subunit)
680646001094	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
680646001095	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
680646001096	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
680646001097	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
680646001098	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
680646001099	putative substrate translocation pore; other site
680646001100	glycine dehydrogenase; Provisional; Region: PRK05367
680646001101	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
680646001102	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
680646001103	catalytic residue [active]
680646001104	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
680646001105	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
680646001106	catalytic residue [active]
680646001107	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
680646001108	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
680646001109	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
680646001110	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
680646001111	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
680646001112	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
680646001113	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
680646001114	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
680646001115	RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591
680646001116	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
680646001117	RPB1 interaction site [polypeptide binding]; other site
680646001118	RPB10 interaction site [polypeptide binding]; other site
680646001119	RPB11 interaction site [polypeptide binding]; other site
680646001120	RPB3 interaction site [polypeptide binding]; other site
680646001121	RPB12 interaction site [polypeptide binding]; other site
680646001122	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
680646001123	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
680646001124	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
680646001125	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
680646001126	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
680646001127	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
680646001128	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
680646001129	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
680646001130	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
680646001131	G-loop; other site
680646001132	DNA binding site [nucleotide binding]
680646001133	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
680646001134	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
680646001135	S17 interaction site [polypeptide binding]; other site
680646001136	S8 interaction site; other site
680646001137	16S rRNA interaction site [nucleotide binding]; other site
680646001138	streptomycin interaction site [chemical binding]; other site
680646001139	23S rRNA interaction site [nucleotide binding]; other site
680646001140	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
680646001141	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
680646001142	elongation factor G; Reviewed; Region: PRK00007
680646001143	Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase).  The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA.  This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886
680646001144	G1 box; other site
680646001145	putative GEF interaction site [polypeptide binding]; other site
680646001146	GTP/Mg2+ binding site [chemical binding]; other site
680646001147	Switch I region; other site
680646001148	G2 box; other site
680646001149	G3 box; other site
680646001150	Switch II region; other site
680646001151	G4 box; other site
680646001152	G5 box; other site
680646001153	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088
680646001154	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434
680646001155	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713
680646001156	elongation factor Tu; Reviewed; Region: PRK00049
680646001157	EF-Tu subfamily.  This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts.  It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884
680646001158	G1 box; other site
680646001159	GEF interaction site [polypeptide binding]; other site
680646001160	GTP/Mg2+ binding site [chemical binding]; other site
680646001161	Switch I region; other site
680646001162	G2 box; other site
680646001163	G3 box; other site
680646001164	Switch II region; other site
680646001165	G4 box; other site
680646001166	G5 box; other site
680646001167	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
680646001168	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707
680646001169	Antibiotic Binding Site [chemical binding]; other site
680646001170	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
680646001171	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
680646001172	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
680646001173	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
680646001174	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
680646001175	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
680646001176	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
680646001177	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
680646001178	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
680646001179	putative translocon binding site; other site
680646001180	protein-rRNA interface [nucleotide binding]; other site
680646001181	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
680646001182	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The...; Region: 30S_S3_KH; cd02412
680646001183	G-X-X-G motif; other site
680646001184	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
680646001185	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
680646001186	23S rRNA interface [nucleotide binding]; other site
680646001187	putative antibiotic binding site [chemical binding]; other site
680646001188	L25 interface [polypeptide binding]; other site
680646001189	L27 interface [polypeptide binding]; other site
680646001190	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427
680646001191	putative translocon interaction site; other site
680646001192	23S rRNA interface [nucleotide binding]; other site
680646001193	signal recognition particle (SRP54) interaction site; other site
680646001194	L23 interface [polypeptide binding]; other site
680646001195	trigger factor interaction site; other site
680646001196	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
680646001197	Uncharacterized conserved protein [Function unknown]; Region: COG3391
680646001198	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567
680646001199	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950
680646001200	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
680646001201	KOW motif; Region: KOW; cl00354
680646001202	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
680646001203	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
680646001204	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
680646001205	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
680646001206	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
680646001207	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
680646001208	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
680646001209	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
680646001210	5S rRNA interface [nucleotide binding]; other site
680646001211	L27 interface [polypeptide binding]; other site
680646001212	23S rRNA interface [nucleotide binding]; other site
680646001213	L5 interface [polypeptide binding]; other site
680646001214	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
680646001215	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
680646001216	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
680646001217	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658
680646001218	23S rRNA binding site [nucleotide binding]; other site
680646001219	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
680646001220	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
680646001221	SecY translocase; Region: SecY; pfam00344
680646001222	adenylate kinase; Reviewed; Region: adk; PRK00279
680646001223	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
680646001224	AMP-binding site [chemical binding]; other site
680646001225	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
680646001226	methionine aminopeptidase; Reviewed; Region: PRK07281
680646001227	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
680646001228	active site
680646001229	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056
680646001230	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
680646001231	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
680646001232	rRNA binding site [nucleotide binding]; other site
680646001233	predicted 30S ribosome binding site; other site
680646001234	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
680646001235	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
680646001236	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
680646001237	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
680646001238	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
680646001239	alphaNTD - beta interaction site [polypeptide binding]; other site
680646001240	alphaNTD homodimer interface [polypeptide binding]; other site
680646001241	alphaNTD - beta' interaction site [polypeptide binding]; other site
680646001242	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
680646001243	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
680646001244	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
680646001245	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
680646001246	PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570
680646001247	dimerization interface 3.5A [polypeptide binding]; other site
680646001248	active site
680646001249	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
680646001250	23S rRNA interface [nucleotide binding]; other site
680646001251	L3 interface [polypeptide binding]; other site
680646001252	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
680646001253	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646001254	Active site [active]
680646001255	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
680646001256	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802
680646001257	active site
680646001258	substrate binding site [chemical binding]; other site
680646001259	metal binding site [ion binding]; metal-binding site
680646001260	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
680646001261	pantothenate kinase; Provisional; Region: PRK05439
680646001262	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025
680646001263	ATP-binding site [chemical binding]; other site
680646001264	CoA-binding site [chemical binding]; other site
680646001265	Mg2+-binding site [ion binding]; other site
680646001266	potential protein location (hypothetical protein) that overlaps protein (glucosamine 6-phosphate synthetase)
680646001267	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
680646001268	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714
680646001269	glutaminase active site [active]
680646001270	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
680646001271	dimer interface [polypeptide binding]; other site
680646001272	active site
680646001273	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
680646001274	dimer interface [polypeptide binding]; other site
680646001275	active site
680646001276	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
680646001277	putative carbohydrate kinase; Provisional; Region: PRK10565
680646001278	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
680646001279	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
680646001280	putative substrate binding site [chemical binding]; other site
680646001281	putative ATP binding site [chemical binding]; other site
680646001282	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
680646001283	Bacterial sugar transferase; Region: Bac_transf; cl00939
680646001284	UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449
680646001285	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
680646001286	putative ADP-binding pocket [chemical binding]; other site
680646001287	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
680646001288	alanine racemase; Reviewed; Region: alr; PRK00053
680646001289	active site
680646001290	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
680646001291	dimer interface [polypeptide binding]; other site
680646001292	substrate binding site [chemical binding]; other site
680646001293	catalytic residues [active]
680646001294	Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520
680646001295	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
680646001296	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
680646001297	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
680646001298	Coenzyme A binding pocket [chemical binding]; other site
680646001299	putative glycoprotease GCP; Region: bact_gcp; TIGR03723
680646001300	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
680646001301	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
680646001302	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
680646001303	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
680646001304	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320
680646001305	oligomerisation interface [polypeptide binding]; other site
680646001306	mobile loop; other site
680646001307	roof hairpin; other site
680646001308	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
680646001309	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
680646001310	ring oligomerisation interface [polypeptide binding]; other site
680646001311	ATP/Mg binding site [chemical binding]; other site
680646001312	stacking interactions; other site
680646001313	hinge regions; other site
680646001314	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
680646001315	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
680646001316	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601
680646001317	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381
680646001318	active site
680646001319	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
680646001320	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
680646001321	phosphate binding site [ion binding]; other site
680646001322	GMP synthase; Reviewed; Region: guaA; PRK00074
680646001323	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
680646001324	AMP/PPi binding site [chemical binding]; other site
680646001325	candidate oxyanion hole; other site
680646001326	catalytic triad [active]
680646001327	potential glutamine specificity residues [chemical binding]; other site
680646001328	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
680646001329	ATP Binding subdomain [chemical binding]; other site
680646001330	Ligand Binding sites [chemical binding]; other site
680646001331	Dimerization subdomain; other site
680646001332	Membrane transport protein; Region: Mem_trans; cl09117
680646001333	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
680646001334	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
680646001335	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
680646001336	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
680646001337	Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079
680646001338	putative catalytic site [active]
680646001339	putative metal binding site [ion binding]; other site
680646001340	putative phosphate binding site [ion binding]; other site
680646001341	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
680646001342	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
680646001343	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212
680646001344	active site turn [active]
680646001345	phosphorylation site [posttranslational modification]
680646001346	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
680646001347	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013
680646001348	putative active site [active]
680646001349	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
680646001350	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
680646001351	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
680646001352	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
680646001353	active site
680646001354	tetramer interface [polypeptide binding]; other site
680646001355	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
680646001356	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
680646001357	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
680646001358	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X...; Region: Nudix_Hydrolase_25; cd04684
680646001359	nudix motif; other site
680646001360	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
680646001361	alanine aminotransferase; Provisional; Region: PTZ00377
680646001362	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
680646001363	pyridoxal 5'-phosphate binding site [chemical binding]; other site
680646001364	homodimer interface [polypeptide binding]; other site
680646001365	catalytic residue [active]
680646001366	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
680646001367	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
680646001368	LytB protein; Region: LYTB; cl00507
680646001369	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
680646001370	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
680646001371	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
680646001372	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646001373	Walker A/P-loop; other site
680646001374	ATP binding site [chemical binding]; other site
680646001375	Q-loop/lid; other site
680646001376	ABC transporter signature motif; other site
680646001377	Walker B; other site
680646001378	D-loop; other site
680646001379	H-loop/switch region; other site
680646001380	ABC-2 type transporter; Region: ABC2_membrane; cl11417
680646001381	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
680646001382	Histidine kinase; Region: HisKA_3; pfam07730
680646001383	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
680646001384	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
680646001385	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
680646001386	active site
680646001387	phosphorylation site [posttranslational modification]
680646001388	intermolecular recognition site; other site
680646001389	dimerization interface [polypeptide binding]; other site
680646001390	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
680646001391	DNA binding residues [nucleotide binding]
680646001392	dimerization interface [polypeptide binding]; other site
680646001393	GTP-binding protein YchF; Reviewed; Region: PRK09601
680646001394	YchF subfamily.  YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1.  Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900
680646001395	G1 box; other site
680646001396	GTP/Mg2+ binding site [chemical binding]; other site
680646001397	Switch I region; other site
680646001398	G2 box; other site
680646001399	Switch II region; other site
680646001400	G3 box; other site
680646001401	G4 box; other site
680646001402	G5 box; other site
680646001403	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
680646001404	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646001405	Walker A/P-loop; other site
680646001406	ATP binding site [chemical binding]; other site
680646001407	ABC transporter signature motif; other site
680646001408	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
680646001409	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646001410	Q-loop/lid; other site
680646001411	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4694
680646001412	ABC transporter signature motif; other site
680646001413	Walker B; other site
680646001414	D-loop; other site
680646001415	H-loop/switch region; other site
680646001416	TOBE domain; Region: TOBE_2; cl01440
680646001417	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
680646001418	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
680646001419	PhnA protein; Region: PhnA; pfam03831
680646001420	Predicted membrane protein [Function unknown]; Region: COG4270
680646001421	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
680646001422	dimer interface [polypeptide binding]; other site
680646001423	catalytic triad [active]
680646001424	peroxidatic and resolving cysteines [active]
680646001425	AzlC protein; Region: AzlC; cl00570
680646001426	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
680646001427	AzlC protein; Region: AzlC; cl00570
680646001428	OsmC-like protein; Region: OsmC; cl00767
680646001429	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
680646001430	Amino acid permease; Region: AA_permease; pfam00324
680646001431	Neisseria meningitidis TspB protein; Region: Neisseria_TspB; pfam05616
680646001432	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
680646001433	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
680646001434	nudix motif; other site
680646001435	DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695
680646001436	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
680646001437	putative substrate binding pocket [chemical binding]; other site
680646001438	AC domain interface; other site
680646001439	catalytic triad [active]
680646001440	AB domain interface; other site
680646001441	potential protein location (hypothetical protein) that overlaps protein (glucose-6-phosphate isomerase)
680646001442	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
680646001443	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
680646001444	active site
680646001445	dimer interface [polypeptide binding]; other site
680646001446	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
680646001447	dimer interface [polypeptide binding]; other site
680646001448	active site
680646001449	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
680646001450	putative NADH binding site [chemical binding]; other site
680646001451	putative active site [active]
680646001452	nudix motif; other site
680646001453	putative metal binding site [ion binding]; other site
680646001454	TypA (tyrosine phosphorylated protein A)/BipA subfamily.  BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants.  BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891
680646001455	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
680646001456	G1 box; other site
680646001457	putative GEF interaction site [polypeptide binding]; other site
680646001458	GTP/Mg2+ binding site [chemical binding]; other site
680646001459	Switch I region; other site
680646001460	G2 box; other site
680646001461	G3 box; other site
680646001462	Switch II region; other site
680646001463	G4 box; other site
680646001464	G5 box; other site
680646001465	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
680646001466	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a...; Region: BipA_TypA_C; cd03710
680646001467	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
680646001468	Ferredoxin [Energy production and conversion]; Region: COG1146
680646001469	4Fe-4S binding domain; Region: Fer4; cl02805
680646001470	aspartate aminotransferase; Provisional; Region: PRK07681
680646001471	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
680646001472	pyridoxal 5'-phosphate binding site [chemical binding]; other site
680646001473	homodimer interface [polypeptide binding]; other site
680646001474	catalytic residue [active]
680646001475	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
680646001476	dimer interface [polypeptide binding]; other site
680646001477	conserved gate region; other site
680646001478	putative PBP binding loops; other site
680646001479	ABC-ATPase subunit interface; other site
680646001480	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
680646001481	dimer interface [polypeptide binding]; other site
680646001482	conserved gate region; other site
680646001483	putative PBP binding loops; other site
680646001484	ABC-ATPase subunit interface; other site
680646001485	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
680646001486	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
680646001487	substrate binding pocket [chemical binding]; other site
680646001488	membrane-bound complex binding site; other site
680646001489	hinge residues; other site
680646001490	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
680646001491	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262
680646001492	Walker A/P-loop; other site
680646001493	ATP binding site [chemical binding]; other site
680646001494	Q-loop/lid; other site
680646001495	ABC transporter signature motif; other site
680646001496	Walker B; other site
680646001497	D-loop; other site
680646001498	H-loop/switch region; other site
680646001499	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
680646001500	UDP-glucose 4-epimerase; Region: PLN02240
680646001501	NAD binding site [chemical binding]; other site
680646001502	homodimer interface [polypeptide binding]; other site
680646001503	active site
680646001504	substrate binding site [chemical binding]; other site
680646001505	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
680646001506	Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956
680646001507	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
680646001508	putative trimer interface [polypeptide binding]; other site
680646001509	putative CoA binding site [chemical binding]; other site
680646001510	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
680646001511	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
680646001512	metal binding site [ion binding]; metal-binding site
680646001513	putative dimer interface [polypeptide binding]; other site
680646001514	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
680646001515	Domain of unknown function DUF59; Region: DUF59; cl00941
680646001516	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
680646001517	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
680646001518	Protein of unknown function (DUF1003); Region: DUF1003; cl01831
680646001519	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
680646001520	MgtE intracellular N domain; Region: MgtE_N; cl15244
680646001521	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
680646001522	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
680646001523	proline aminopeptidase P II; Provisional; Region: PRK10879
680646001524	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action...; Region: Prolidase; cd01087
680646001525	active site
680646001526	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
680646001527	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
680646001528	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
680646001529	potential protein location (hypothetical protein) that overlaps protein (superfamily II DNA and RNA helicase)
680646001530	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif (...; Region: DEADc; cd00268
680646001531	DEAD-like helicases superfamily; Region: DEXDc; smart00487
680646001532	ATP binding site [chemical binding]; other site
680646001533	Mg++ binding site [ion binding]; other site
680646001534	motif III; other site
680646001535	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
680646001536	nucleotide binding region [chemical binding]; other site
680646001537	ATP-binding site [chemical binding]; other site
680646001538	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
680646001539	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
680646001540	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
680646001541	NAD(P) binding pocket [chemical binding]; other site
680646001542	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
680646001543	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717
680646001544	substrate binding site [chemical binding]; other site
680646001545	active site
680646001546	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
680646001547	Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232
680646001548	Chlorite dismutase; Region: Chlor_dismutase; cl01280
680646001549	ferrochelatase; Reviewed; Region: hemH; PRK00035
680646001550	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
680646001551	C-terminal domain interface [polypeptide binding]; other site
680646001552	active site
680646001553	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
680646001554	active site
680646001555	N-terminal domain interface [polypeptide binding]; other site
680646001556	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189
680646001557	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
680646001558	domain interfaces; other site
680646001559	active site
680646001560	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578
680646001561	active site
680646001562	Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602
680646001563	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
680646001564	dimer interface [polypeptide binding]; other site
680646001565	active site
680646001566	Schiff base residues; other site
680646001567	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
680646001568	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610
680646001569	inhibitor-cofactor binding pocket; inhibition site
680646001570	pyridoxal 5'-phosphate binding site [chemical binding]; other site
680646001571	catalytic residue [active]
680646001572	Uncharacterized conserved protein [Function unknown]; Region: COG2966
680646001573	Protein of unknown function (DUF1212); Region: DUF1212; cl01118
680646001574	Protein of unknown function (DUF1212); Region: DUF1212; cl01118
680646001575	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
680646001576	active site
680646001577	substrate binding site [chemical binding]; other site
680646001578	catalytic site [active]
680646001579	UvrD/REP helicase; Region: UvrD-helicase; cl14126
680646001580	UvrD/REP helicase; Region: UvrD-helicase; cl14126
680646001581	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
680646001582	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
680646001583	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
680646001584	UvrD/REP helicase; Region: UvrD-helicase; cl14126
680646001585	UvrD/REP helicase; Region: UvrD-helicase; cl14126
680646001586	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
680646001587	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
680646001588	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
680646001589	active site
680646001590	ATP binding site [chemical binding]; other site
680646001591	substrate binding site [chemical binding]; other site
680646001592	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
680646001593	UvrD/REP helicase; Region: UvrD-helicase; cl14126
680646001594	Protein of unknown function DUF45; Region: DUF45; cl00636
680646001595	Uncharacterised conserved protein (DUF2342); Region: DUF2342; cl02183
680646001596	potential protein location (hypothetical protein) that overlaps protein (predicted secreted protein containing a PDZ domain)
680646001597	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
680646001598	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989
680646001599	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
680646001600	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
680646001601	Uncharacterised protein family (UPF0182); Region: UPF0182; pfam03699
680646001602	Transposase, Mutator family; Region: Transposase_mut; pfam00872
680646001603	MULE transposase domain; Region: MULE; pfam10551
680646001604	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
680646001605	S-layer homology domain; Region: SLH; pfam00395
680646001606	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
680646001607	phage shock protein PspA; Provisional; Region: PRK10698
680646001608	Domain of unknown function (DUF477); Region: DUF477; cl01535
680646001609	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
680646001610	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149
680646001611	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
680646001612	protein binding site [polypeptide binding]; other site
680646001613	Uracil DNA glycosylase superfamily; Region: UDG; cl00483
680646001614	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
680646001615	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
680646001616	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
680646001617	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
680646001618	catalytic residue [active]
680646001619	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998
680646001620	Chorismate mutase type II; Region: CM_2; cl00693
680646001621	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine...; Region: URO-D_CIMS_like; cl00464
680646001622	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
680646001623	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
680646001624	active site
680646001625	phosphorylation site [posttranslational modification]
680646001626	intermolecular recognition site; other site
680646001627	dimerization interface [polypeptide binding]; other site
680646001628	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
680646001629	DNA binding site [nucleotide binding]
680646001630	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
680646001631	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
680646001632	dimer interface [polypeptide binding]; other site
680646001633	phosphorylation site [posttranslational modification]
680646001634	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
680646001635	ATP binding site [chemical binding]; other site
680646001636	Mg2+ binding site [ion binding]; other site
680646001637	G-X-G motif; other site
680646001638	lipoprotein LpqB; Provisional; Region: PRK13614
680646001639	Sporulation and spore germination; Region: Germane; pfam10646
680646001640	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552
680646001641	30S subunit binding site; other site
680646001642	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
680646001643	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882
680646001644	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
680646001645	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
680646001646	nucleotide binding region [chemical binding]; other site
680646001647	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107
680646001648	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
680646001649	SAF domain; Region: SAF; cl00555
680646001650	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
680646001651	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
680646001652	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
680646001653	PAS fold; Region: PAS_4; pfam08448
680646001654	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
680646001655	Histidine kinase; Region: HisKA_2; cl06527
680646001656	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
680646001657	ATP binding site [chemical binding]; other site
680646001658	Mg2+ binding site [ion binding]; other site
680646001659	G-X-G motif; other site
680646001660	Transcription factor WhiB; Region: Whib; pfam02467
680646001661	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
680646001662	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646001663	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
680646001664	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
680646001665	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
680646001666	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
680646001667	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
680646001668	ABC-2 type transporter; Region: ABC2_membrane; cl11417
680646001669	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
680646001670	ABC_KpsT_Wzt   The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export.  Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220
680646001671	Walker A/P-loop; other site
680646001672	ATP binding site [chemical binding]; other site
680646001673	Q-loop/lid; other site
680646001674	ABC transporter signature motif; other site
680646001675	Walker B; other site
680646001676	D-loop; other site
680646001677	H-loop/switch region; other site
680646001678	helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819
680646001679	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130
680646001680	Walker A motif; other site
680646001681	hexamer interface [polypeptide binding]; other site
680646001682	ATP binding site [chemical binding]; other site
680646001683	Walker B motif; other site
680646001684	Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
680646001685	potential protein location (hypothetical protein) that overlaps protein (Flp pilus assembly protein TadC)
680646001686	Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
680646001687	TadE-like protein; Region: TadE; pfam07811
680646001688	peptide chain release factor 2; Validated; Region: prfB; PRK00578
680646001689	RF-1 domain; Region: RF-1; cl02875
680646001690	RF-1 domain; Region: RF-1; cl02875
680646001691	potential protein location (hypothetical protein) that overlaps protein (tmRNA-binding protein)
680646001692	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
680646001693	SmpB-tmRNA interface; other site
680646001694	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
680646001695	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
680646001696	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
680646001697	active site
680646001698	Predicted GTPases [General function prediction only]; Region: COG1162
680646001699	YjeQ/EngC.  YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854
680646001700	GTPase/OB domain interface [polypeptide binding]; other site
680646001701	GTPase/Zn-binding domain interface [polypeptide binding]; other site
680646001702	GTP/Mg2+ binding site [chemical binding]; other site
680646001703	G4 box; other site
680646001704	G5 box; other site
680646001705	G1 box; other site
680646001706	Switch I region; other site
680646001707	G2 box; other site
680646001708	G3 box; other site
680646001709	Switch II region; other site
680646001710	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
680646001711	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556
680646001712	hinge; other site
680646001713	active site
680646001714	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl11829
680646001715	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
680646001716	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
680646001717	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
680646001718	DNA binding residues [nucleotide binding]
680646001719	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
680646001720	active site
680646001721	catalytic triad [active]
680646001722	oxyanion hole [active]
680646001723	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
680646001724	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
680646001725	TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of...; Region: TPP_E1_OGDC_like; cd02016
680646001726	TPP-binding site [chemical binding]; other site
680646001727	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
680646001728	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
680646001729	Domain of unknown function DUF21; Region: DUF21; pfam01595
680646001730	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
680646001731	Transporter associated domain; Region: CorC_HlyC; pfam03471
680646001732	Domain of unknown function DUF21; Region: DUF21; pfam01595
680646001733	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
680646001734	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262
680646001735	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
680646001736	intersubunit interface [polypeptide binding]; other site
680646001737	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
680646001738	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235
680646001739	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462
680646001740	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
680646001741	metal binding site 2 [ion binding]; metal-binding site
680646001742	putative DNA binding helix; other site
680646001743	metal binding site 1 [ion binding]; metal-binding site
680646001744	dimer interface [polypeptide binding]; other site
680646001745	structural Zn2+ binding site [ion binding]; other site
680646001746	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
680646001747	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228
680646001748	nucleotide binding site/active site [active]
680646001749	HIT family signature motif; other site
680646001750	catalytic residue [active]
680646001751	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408
680646001752	glutamine synthetase, type I; Region: GlnA; TIGR00653
680646001753	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
680646001754	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
680646001755	WzyE protein; Region: WzyE; cl11643
680646001756	lipoyl synthase; Provisional; Region: PRK05481
680646001757	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
680646001758	FeS/SAM binding site; other site
680646001759	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
680646001760	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
680646001761	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
680646001762	E3 interaction surface; other site
680646001763	lipoyl attachment site [posttranslational modification]; other site
680646001764	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
680646001765	E3 interaction surface; other site
680646001766	lipoyl attachment site [posttranslational modification]; other site
680646001767	e3 binding domain; Region: E3_binding; pfam02817
680646001768	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
680646001769	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
680646001770	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
680646001771	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
680646001772	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
680646001773	multifunctional aminopeptidase A; Provisional; Region: PRK00913
680646001774	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433
680646001775	interface (dimer of trimers) [polypeptide binding]; other site
680646001776	Substrate-binding/catalytic site; other site
680646001777	Zn-binding sites [ion binding]; other site
680646001778	PAC2 family; Region: PAC2; cl00847
680646001779	potential protein location (hypothetical protein) that overlaps protein (DNA-directed RNA polymerase, sigma subunit)
680646001780	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
680646001781	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
680646001782	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
680646001783	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
680646001784	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
680646001785	DNA binding residues [nucleotide binding]
680646001786	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
680646001787	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
680646001788	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
680646001789	active site
680646001790	metal binding site [ion binding]; metal-binding site
680646001791	DNA binding site [nucleotide binding]
680646001792	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
680646001793	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646001794	Walker A/P-loop; other site
680646001795	ATP binding site [chemical binding]; other site
680646001796	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
680646001797	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646001798	Walker B; other site
680646001799	D-loop; other site
680646001800	H-loop/switch region; other site
680646001801	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948
680646001802	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
680646001803	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
680646001804	mycothiol-dependent formaldehyde dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
680646001805	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
680646001806	NAD binding site [chemical binding]; other site
680646001807	catalytic Zn binding site [ion binding]; other site
680646001808	substrate binding site [chemical binding]; other site
680646001809	structural Zn binding site [ion binding]; other site
680646001810	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
680646001811	Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918
680646001812	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881
680646001813	Predicted dehydrogenase [General function prediction only]; Region: COG0579
680646001814	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
680646001815	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
680646001816	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017
680646001817	catalytic triad [active]
680646001818	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
680646001819	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
680646001820	PYR/PP interface [polypeptide binding]; other site
680646001821	dimer interface [polypeptide binding]; other site
680646001822	TPP binding site [chemical binding]; other site
680646001823	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
680646001824	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
680646001825	TPP-binding site [chemical binding]; other site
680646001826	dimer interface [polypeptide binding]; other site
680646001827	potential protein location (hypothetical protein) that overlaps protein (acetolactate synthase, small (regulatory) subunit)
680646001828	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
680646001829	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
680646001830	putative valine binding site [chemical binding]; other site
680646001831	dimer interface [polypeptide binding]; other site
680646001832	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
680646001833	potential protein location (hypothetical protein) that overlaps protein (ketol-acid reductoisomerase)
680646001834	ketol-acid reductoisomerase; Provisional; Region: PRK05479
680646001835	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
680646001836	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
680646001837	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
680646001838	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
680646001839	active site
680646001840	HIGH motif; other site
680646001841	KMSKS motif; other site
680646001842	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
680646001843	tRNA binding surface [nucleotide binding]; other site
680646001844	anticodon binding site; other site
680646001845	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
680646001846	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
680646001847	Walker A/P-loop; other site
680646001848	ATP binding site [chemical binding]; other site
680646001849	Q-loop/lid; other site
680646001850	ABC transporter signature motif; other site
680646001851	Walker B; other site
680646001852	D-loop; other site
680646001853	H-loop/switch region; other site
680646001854	FtsX-like permease family; Region: FtsX; pfam02687
680646001855	FtsX-like permease family; Region: FtsX; pfam02687
680646001856	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
680646001857	active site
680646001858	NTP binding site [chemical binding]; other site
680646001859	metal binding triad [ion binding]; metal-binding site
680646001860	antibiotic binding site [chemical binding]; other site
680646001861	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
680646001862	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
680646001863	active site
680646001864	phosphorylation site [posttranslational modification]
680646001865	intermolecular recognition site; other site
680646001866	dimerization interface [polypeptide binding]; other site
680646001867	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
680646001868	DNA binding residues [nucleotide binding]
680646001869	dimerization interface [polypeptide binding]; other site
680646001870	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
680646001871	Histidine kinase; Region: HisKA_3; pfam07730
680646001872	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
680646001873	potential protein location (hypothetical protein) that overlaps protein (signal transduction histidine kinase)
680646001874	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
680646001875	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
680646001876	potential protein location (hypothetical protein) that overlaps protein (isocitrate/isopropylmalate dehydrogenase)
680646001877	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
680646001878	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
680646001879	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557
680646001880	homodimer interface [polypeptide binding]; other site
680646001881	substrate-cofactor binding pocket; other site
680646001882	catalytic residue [active]
680646001883	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
680646001884	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
680646001885	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
680646001886	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
680646001887	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
680646001888	HIGH motif; other site
680646001889	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
680646001890	active site
680646001891	KMSKS motif; other site
680646001892	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
680646001893	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487
680646001894	active site
680646001895	catalytic residues [active]
680646001896	metal binding site [ion binding]; metal-binding site
680646001897	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
680646001898	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
680646001899	putative active site [active]
680646001900	substrate binding site [chemical binding]; other site
680646001901	putative cosubstrate binding site; other site
680646001902	catalytic site [active]
680646001903	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
680646001904	substrate binding site [chemical binding]; other site
680646001905	16S rRNA methyltransferase B; Provisional; Region: PRK14902
680646001906	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223
680646001907	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
680646001908	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
680646001909	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429
680646001910	substrate binding site [chemical binding]; other site
680646001911	hexamer interface [polypeptide binding]; other site
680646001912	metal binding site [ion binding]; metal-binding site
680646001913	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor...; Region: FhuD; cd01146
680646001914	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
680646001915	siderophore binding site; other site
680646001916	potential protein location (hypothetical protein) that overlaps protein (poly(3-hydroxybutyrate) depolymerase)
680646001917	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
680646001918	ABC-ATPase subunit  interface; other site
680646001919	dimer interface [polypeptide binding]; other site
680646001920	putative PBP binding regions; other site
680646001921	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
680646001922	ABC-ATPase subunit  interface; other site
680646001923	dimer interface [polypeptide binding]; other site
680646001924	putative PBP binding regions; other site
680646001925	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
680646001926	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
680646001927	Walker A/P-loop; other site
680646001928	ATP binding site [chemical binding]; other site
680646001929	Q-loop/lid; other site
680646001930	ABC transporter signature motif; other site
680646001931	Walker B; other site
680646001932	D-loop; other site
680646001933	H-loop/switch region; other site
680646001934	potential protein location (hypothetical protein) that overlaps protein (enterochelin esterase)
680646001935	enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439
680646001936	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
680646001937	2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275
680646001938	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
680646001939	Phosphopantetheine attachment site; Region: PP-binding; cl09936
680646001940	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
680646001941	Condensation domain; Region: Condensation; cl09290
680646001942	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
680646001943	Phosphopantetheine attachment site; Region: PP-binding; cl09936
680646001944	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
680646001945	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
680646001946	dimer interface [polypeptide binding]; other site
680646001947	TPP-binding site [chemical binding]; other site
680646001948	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
680646001949	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
680646001950	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
680646001951	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
680646001952	serine O-acetyltransferase; Region: cysE; TIGR01172
680646001953	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354
680646001954	trimer interface [polypeptide binding]; other site
680646001955	active site
680646001956	substrate binding site [chemical binding]; other site
680646001957	CoA binding site [chemical binding]; other site
680646001958	cysteine synthases; Region: cysKM; TIGR01136
680646001959	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561
680646001960	dimer interface [polypeptide binding]; other site
680646001961	pyridoxal 5'-phosphate binding site [chemical binding]; other site
680646001962	catalytic residue [active]
680646001963	Era (E. coli Ras-like protein)-like.  This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880
680646001964	G1 box; other site
680646001965	GTP/Mg2+ binding site [chemical binding]; other site
680646001966	Switch I region; other site
680646001967	G2 box; other site
680646001968	Switch II region; other site
680646001969	G3 box; other site
680646001970	Era (E. coli Ras-like protein)-like.  This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880
680646001971	G1 box; other site
680646001972	GTP/Mg2+ binding site [chemical binding]; other site
680646001973	Switch I region; other site
680646001974	G2 box; other site
680646001975	Switch II region; other site
680646001976	G3 box; other site
680646001977	Era (E. coli Ras-like protein)-like.  This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880
680646001978	Switch II region; other site
680646001979	G3 box; other site
680646001980	G4 box; other site
680646001981	G5 box; other site
680646001982	Bacterial transcriptional regulator; Region: IclR; pfam01614
680646001983	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
680646001984	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
680646001985	substrate binding site [chemical binding]; other site
680646001986	ligand binding site [chemical binding]; other site
680646001987	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577
680646001988	substrate binding site [chemical binding]; other site
680646001989	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369
680646001990	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
680646001991	hinge; other site
680646001992	active site
680646001993	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
680646001994	putative acyl-acceptor binding pocket; other site
680646001995	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
680646001996	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
680646001997	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
680646001998	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
680646001999	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
680646002000	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
680646002001	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
680646002002	Thiamine monophosphate kinase [Coenzyme metabolism]; Region: ThiL; COG0611
680646002003	ATP binding site [chemical binding]; other site
680646002004	dimerization interface [polypeptide binding]; other site
680646002005	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
680646002006	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
680646002007	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488
680646002008	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
680646002009	ssDNA binding site; other site
680646002010	generic binding surface II; other site
680646002011	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
680646002012	ATP binding site [chemical binding]; other site
680646002013	putative Mg++ binding site [ion binding]; other site
680646002014	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
680646002015	nucleotide binding region [chemical binding]; other site
680646002016	ATP-binding site [chemical binding]; other site
680646002017	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
680646002018	S-adenosylmethionine binding site [chemical binding]; other site
680646002019	Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057
680646002020	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
680646002021	active site
680646002022	(T/H)XGH motif; other site
680646002023	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
680646002024	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
680646002025	ribonuclease III; Reviewed; Region: rnc; PRK00102
680646002026	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593
680646002027	dimerization interface [polypeptide binding]; other site
680646002028	active site
680646002029	metal binding site [ion binding]; metal-binding site
680646002030	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048
680646002031	dsRNA binding site [nucleotide binding]; other site
680646002032	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
680646002033	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
680646002034	DNA binding site [nucleotide binding]
680646002035	catalytic residue [active]
680646002036	H2TH interface [polypeptide binding]; other site
680646002037	putative catalytic residues [active]
680646002038	turnover-facilitating residue; other site
680646002039	intercalation triad [nucleotide binding]; other site
680646002040	8OG recognition residue [nucleotide binding]; other site
680646002041	putative reading head residues; other site
680646002042	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
680646002043	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
680646002044	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
680646002045	NAD(P) binding site [chemical binding]; other site
680646002046	active site
680646002047	haloalkane dehalogenase; Provisional; Region: PRK03204
680646002048	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
680646002049	peptide synthase; Provisional; Region: PRK09274
680646002050	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258
680646002051	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
680646002052	active site
680646002053	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
680646002054	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278
680646002055	Walker A/P-loop; other site
680646002056	ATP binding site [chemical binding]; other site
680646002057	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
680646002058	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646002059	ABC transporter signature motif; other site
680646002060	Walker B; other site
680646002061	D-loop; other site
680646002062	H-loop/switch region; other site
680646002063	tryptophan synthase, beta chain; Region: PLN02618
680646002064	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
680646002065	pyridoxal 5'-phosphate binding site [chemical binding]; other site
680646002066	catalytic residue [active]
680646002067	tryptophan synthase; Region: PLN02591
680646002068	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724
680646002069	substrate binding site [chemical binding]; other site
680646002070	active site
680646002071	catalytic residues [active]
680646002072	heterodimer interface [polypeptide binding]; other site
680646002073	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
680646002074	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
680646002075	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
680646002076	NAD binding site [chemical binding]; other site
680646002077	substrate binding site [chemical binding]; other site
680646002078	catalytic Zn binding site [ion binding]; other site
680646002079	tetramer interface [polypeptide binding]; other site
680646002080	structural Zn binding site [ion binding]; other site
680646002081	CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans.  CH-type lysozymes exhibit both lysozyme (; Region: GH25_CH-type; cd06412
680646002082	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
680646002083	active site
680646002084	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
680646002085	potential protein location (hypothetical protein) that overlaps protein (pyruvate kinase)
680646002086	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
680646002087	pyruvate kinase; Provisional; Region: PRK06247
680646002088	domain interfaces; other site
680646002089	active site
680646002090	signal recognition particle protein; Provisional; Region: PRK10867
680646002091	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
680646002092	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
680646002093	P loop; other site
680646002094	GTP binding site [chemical binding]; other site
680646002095	Signal peptide binding domain; Region: SRP_SPB; pfam02978
680646002096	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883
680646002097	nudix motif; other site
680646002098	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
680646002099	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794
680646002100	RimM N-terminal domain; Region: RimM; pfam01782
680646002101	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
680646002102	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
680646002103	Protein of unknown function (DUF419); Region: DUF419; cl09948
680646002104	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
680646002105	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
680646002106	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646002107	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
680646002108	ABC transporter; Region: ABC_tran_2; pfam12848
680646002109	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
680646002110	Uncharacterized conserved protein [Function unknown]; Region: HdeD; cl01277
680646002111	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
680646002112	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
680646002113	active site
680646002114	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
680646002115	catalytic triad [active]
680646002116	dimer interface [polypeptide binding]; other site
680646002117	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
680646002118	active site
680646002119	catalytic triad [active]
680646002120	oxyanion hole [active]
680646002121	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
680646002122	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
680646002123	Zn binding site [ion binding]; other site
680646002124	Domain of unknown function (DUF3358); Region: DUF3358; pfam11838
680646002125	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
680646002126	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
680646002127	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
680646002128	putative DNA binding site [nucleotide binding]; other site
680646002129	catalytic residue [active]
680646002130	putative H2TH interface [polypeptide binding]; other site
680646002131	putative catalytic residues [active]
680646002132	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
680646002133	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
680646002134	potential protein location (hypothetical protein) that overlaps protein (FKBP-type peptidyl-prolyl cis-trans isomerase)
680646002135	trigger factor; Provisional; Region: tig; PRK01490
680646002136	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
680646002137	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
680646002138	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
680646002139	oligomer interface [polypeptide binding]; other site
680646002140	active site residues [active]
680646002141	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
680646002142	oligomer interface [polypeptide binding]; other site
680646002143	active site residues [active]
680646002144	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
680646002145	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
680646002146	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646002147	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
680646002148	Walker A motif; other site
680646002149	ATP binding site [chemical binding]; other site
680646002150	Walker B motif; other site
680646002151	potential protein location (hypothetical protein) that overlaps protein (2-hydroxychromene-2-carboxylate isomerase)
680646002152	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
680646002153	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
680646002154	valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208
680646002155	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
680646002156	active site
680646002157	HIGH motif; other site
680646002158	nucleotide binding site [chemical binding]; other site
680646002159	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
680646002160	active site
680646002161	KMSKS motif; other site
680646002162	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
680646002163	tRNA binding surface [nucleotide binding]; other site
680646002164	anticodon binding site; other site
680646002165	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
680646002166	NAD(P) binding site [chemical binding]; other site
680646002167	active site
680646002168	Htaa; Region: HtaA; pfam04213
680646002169	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_N; cd03416
680646002170	putative active site [active]
680646002171	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain...; Region: Rieske_NirD; cd03529
680646002172	nitrite reductase subunit NirD; Provisional; Region: PRK14989
680646002173	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
680646002174	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
680646002175	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
680646002176	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
680646002177	Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060
680646002178	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
680646002179	HIGH motif; other site
680646002180	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
680646002181	active site
680646002182	KMSKS motif; other site
680646002183	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
680646002184	tRNA binding surface [nucleotide binding]; other site
680646002185	anticodon binding site; other site
680646002186	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
680646002187	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
680646002188	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
680646002189	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
680646002190	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243
680646002191	Vitamin K epoxide reductase family; Region: VKOR; cl01729
680646002192	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
680646002193	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
680646002194	homodimer interface [polypeptide binding]; other site
680646002195	oligonucleotide binding site [chemical binding]; other site
680646002196	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
680646002197	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
680646002198	potential protein location (hypothetical protein) that overlaps protein (predicted GTPase)
680646002199	GTPase CgtA; Reviewed; Region: obgE; PRK12296
680646002200	GTP1/OBG; Region: GTP1_OBG; pfam01018
680646002201	Obg subfamily.  The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation.  Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898
680646002202	G1 box; other site
680646002203	GTP/Mg2+ binding site [chemical binding]; other site
680646002204	Switch I region; other site
680646002205	G2 box; other site
680646002206	G3 box; other site
680646002207	Switch II region; other site
680646002208	G4 box; other site
680646002209	G5 box; other site
680646002210	Domain of unknown function (DUF1967); Region: DUF1967; cl07779
680646002211	Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057
680646002212	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
680646002213	active site
680646002214	(T/H)XGH motif; other site
680646002215	Domain of unknown function DUF143; Region: DUF143; cl00519
680646002216	Cation efflux family; Region: Cation_efflux; cl00316
680646002217	Glutaminase; Region: Glutaminase; cl00907
680646002218	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
680646002219	Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061
680646002220	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
680646002221	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
680646002222	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
680646002223	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
680646002224	catalytic residues [active]
680646002225	Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061
680646002226	Uncharacterized conserved protein (DUF2183); Region: DUF2183; cl02012
680646002227	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976
680646002228	catalytic residues [active]
680646002229	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
680646002230	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
680646002231	Class I ribonucleotide reductase; Region: RNR_I; cd01679
680646002232	active site
680646002233	dimer interface [polypeptide binding]; other site
680646002234	catalytic residues [active]
680646002235	effector binding site; other site
680646002236	R2 peptide binding site; other site
680646002237	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
680646002238	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
680646002239	dimer interface [polypeptide binding]; other site
680646002240	putative radical transfer pathway; other site
680646002241	diiron center [ion binding]; other site
680646002242	tyrosyl radical; other site
680646002243	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
680646002244	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
680646002245	catalytic Zn binding site [ion binding]; other site
680646002246	NAD(P) binding site [chemical binding]; other site
680646002247	structural Zn binding site [ion binding]; other site
680646002248	Formate--tetrahydrofolate ligase; Region: FTHFS; pfam01268
680646002249	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
680646002250	Potassium binding sites [ion binding]; other site
680646002251	Cesium cation binding sites [ion binding]; other site
680646002252	potential protein location (hypothetical protein) that overlaps protein (Zn-dependent hydrolase including glyoxylase)
680646002253	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
680646002254	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
680646002255	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
680646002256	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
680646002257	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
680646002258	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
680646002259	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
680646002260	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
680646002261	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
680646002262	dimerization interface [polypeptide binding]; other site
680646002263	putative DNA binding site [nucleotide binding]; other site
680646002264	putative Zn2+ binding site [ion binding]; other site
680646002265	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
680646002266	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
680646002267	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
680646002268	active site
680646002269	dimer interface [polypeptide binding]; other site
680646002270	motif 1; other site
680646002271	motif 2; other site
680646002272	motif 3; other site
680646002273	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
680646002274	anticodon binding site; other site
680646002275	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
680646002276	FAD binding domain; Region: FAD_binding_4; pfam01565
680646002277	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655
680646002278	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
680646002279	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
680646002280	Restriction endonuclease; Region: Mrr_cat; cl00747
680646002281	voltage-gated potassium channel; Provisional; Region: PRK10537
680646002282	Ion channel; Region: Ion_trans_2; cl11596
680646002283	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
680646002284	nucleotide binding site/active site [active]
680646002285	HIT family signature motif; other site
680646002286	catalytic residue [active]
680646002287	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
680646002288	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
680646002289	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
680646002290	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
680646002291	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
680646002292	catalytic triad [active]
680646002293	Domain of unknown function DUF28; Region: DUF28; cl00361
680646002294	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529
680646002295	active site
680646002296	putative DNA-binding cleft [nucleotide binding]; other site
680646002297	dimer interface [polypeptide binding]; other site
680646002298	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
680646002299	RuvA N terminal domain; Region: RuvA_N; pfam01330
680646002300	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
680646002301	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
680646002302	Walker A motif; other site
680646002303	ATP binding site [chemical binding]; other site
680646002304	Walker B motif; other site
680646002305	arginine finger; other site
680646002306	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
680646002307	Preprotein translocase subunit; Region: YajC; cl00806
680646002308	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
680646002309	Protein export membrane protein; Region: SecD_SecF; cl14618
680646002310	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
680646002311	Protein export membrane protein; Region: SecD_SecF; cl14618
680646002312	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
680646002313	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
680646002314	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
680646002315	synthetase active site [active]
680646002316	NTP binding site [chemical binding]; other site
680646002317	metal binding site [ion binding]; metal-binding site
680646002318	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668
680646002319	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
680646002320	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
680646002321	HsdM N-terminal domain; Region: HsdM_N; pfam12161
680646002322	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
680646002323	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
680646002324	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
680646002325	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
680646002326	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
680646002327	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
680646002328	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
680646002329	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
680646002330	ATP binding site [chemical binding]; other site
680646002331	putative Mg++ binding site [ion binding]; other site
680646002332	Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008
680646002333	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
680646002334	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
680646002335	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
680646002336	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
680646002337	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
680646002338	dimer interface [polypeptide binding]; other site
680646002339	motif 1; other site
680646002340	active site
680646002341	motif 2; other site
680646002342	motif 3; other site
680646002343	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
680646002344	anticodon binding site; other site
680646002345	Predicted transcriptional regulator [Transcription]; Region: COG5340
680646002346	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
680646002347	putative active site [active]
680646002348	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
680646002349	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
680646002350	dimer interface [polypeptide binding]; other site
680646002351	anticodon binding site; other site
680646002352	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
680646002353	homodimer interface [polypeptide binding]; other site
680646002354	motif 1; other site
680646002355	active site
680646002356	motif 2; other site
680646002357	GAD domain; Region: GAD; pfam02938
680646002358	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
680646002359	active site
680646002360	motif 3; other site
680646002361	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646002362	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563
680646002363	putative active site [active]
680646002364	dimerization interface [polypeptide binding]; other site
680646002365	putative tRNAtyr binding site [nucleotide binding]; other site
680646002366	recombination factor protein RarA; Reviewed; Region: PRK13342
680646002367	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
680646002368	Walker A motif; other site
680646002369	ATP binding site [chemical binding]; other site
680646002370	Walker B motif; other site
680646002371	MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl13440
680646002372	potential protein location (hypothetical protein) that overlaps protein (ribosomal protein S4)
680646002373	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
680646002374	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
680646002375	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
680646002376	RNA binding surface [nucleotide binding]; other site
680646002377	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
680646002378	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673
680646002379	motif 1; other site
680646002380	active site
680646002381	motif 2; other site
680646002382	motif 3; other site
680646002383	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
680646002384	Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525
680646002385	YceG-like family; Region: YceG; pfam02618
680646002386	proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675
680646002387	dimerization interface [polypeptide binding]; other site
680646002388	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
680646002389	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
680646002390	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
680646002391	shikimate binding site; other site
680646002392	NAD(P) binding site [chemical binding]; other site
680646002393	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
680646002394	Tetramer interface [polypeptide binding]; other site
680646002395	Active site [active]
680646002396	FMN-binding site [chemical binding]; other site
680646002397	potential protein location (hypothetical protein) that overlaps protein (shikimate kinase)
680646002398	shikimate kinase; Reviewed; Region: aroK; PRK00131
680646002399	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464
680646002400	ADP binding site [chemical binding]; other site
680646002401	magnesium binding site [ion binding]; other site
680646002402	putative shikimate binding site; other site
680646002403	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
680646002404	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
680646002405	active site
680646002406	dimer interface [polypeptide binding]; other site
680646002407	metal binding site [ion binding]; metal-binding site
680646002408	elongation factor P; Validated; Region: PRK00529
680646002409	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
680646002410	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470
680646002411	RNA binding site [nucleotide binding]; other site
680646002412	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794
680646002413	RNA binding site [nucleotide binding]; other site
680646002414	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223
680646002415	putative RNA binding site [nucleotide binding]; other site
680646002416	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
680646002417	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
680646002418	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
680646002419	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
680646002420	potential protein location (hypothetical protein) that overlaps protein (membrane-associated lipoprotein involved in thiamine biosynthesis)
680646002421	dihydroorotase; Validated; Region: pyrC; PRK09357
680646002422	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
680646002423	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317
680646002424	active site
680646002425	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
680646002426	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
680646002427	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
680646002428	catalytic site [active]
680646002429	subunit interface [polypeptide binding]; other site
680646002430	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
680646002431	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
680646002432	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
680646002433	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
680646002434	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
680646002435	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
680646002436	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
680646002437	IMP binding site; other site
680646002438	dimer interface [polypeptide binding]; other site
680646002439	interdomain contacts; other site
680646002440	partial ornithine binding site; other site
680646002441	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
680646002442	active site
680646002443	dimer interface [polypeptide binding]; other site
680646002444	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071
680646002445	catalytic site [active]
680646002446	G-X2-G-X-G-K; other site
680646002447	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
680646002448	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
680646002449	Flavoprotein; Region: Flavoprotein; cl08021
680646002450	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
680646002451	P-loop ATPase protein family; Region: ATP_bind_2; cl10035
680646002452	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
680646002453	Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933
680646002454	phosphate binding site [ion binding]; other site
680646002455	putative substrate binding pocket [chemical binding]; other site
680646002456	dimer interface [polypeptide binding]; other site
680646002457	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
680646002458	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
680646002459	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
680646002460	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
680646002461	Competence protein; Region: Competence; cl00471
680646002462	hypothetical protein; Reviewed; Region: PRK07914
680646002463	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
680646002464	PemK-like protein; Region: PemK; cl00995
680646002465	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
680646002466	PAC2 family; Region: PAC2; cl00847
680646002467	GTP-binding protein LepA; Provisional; Region: PRK05433
680646002468	LepA subfamily.  LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome.  LepA is ubiquitous in bacteria and...; Region: LepA; cd01890
680646002469	G1 box; other site
680646002470	putative GEF interaction site [polypeptide binding]; other site
680646002471	GTP/Mg2+ binding site [chemical binding]; other site
680646002472	Switch I region; other site
680646002473	G2 box; other site
680646002474	G3 box; other site
680646002475	Switch II region; other site
680646002476	G4 box; other site
680646002477	G5 box; other site
680646002478	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699
680646002479	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
680646002480	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
680646002481	coproporphyrinogen III oxidase; Validated; Region: PRK05628
680646002482	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
680646002483	FeS/SAM binding site; other site
680646002484	HemN C-terminal region; Region: HemN_C; pfam06969
680646002485	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296
680646002486	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
680646002487	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257
680646002488	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
680646002489	HSP70 interaction site [polypeptide binding]; other site
680646002490	DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908
680646002491	DnaJ C terminal domain; Region: DnaJ_C; pfam01556
680646002492	RNA methyltransferase; Region: Methyltrans_RNA; cl00611
680646002493	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
680646002494	PhoH-like protein; Region: PhoH; cl12134
680646002495	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
680646002496	Domain of unknown function DUF21; Region: DUF21; pfam01595
680646002497	FOG: CBS domain [General function prediction only]; Region: COG0517
680646002498	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
680646002499	Transporter associated domain; Region: CorC_HlyC; pfam03471
680646002500	Era subfamily.  Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria.  It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163
680646002501	G1 box; other site
680646002502	GTP/Mg2+ binding site [chemical binding]; other site
680646002503	Switch I region; other site
680646002504	G2 box; other site
680646002505	Switch II region; other site
680646002506	G3 box; other site
680646002507	G4 box; other site
680646002508	GTPase Era; Reviewed; Region: era; PRK00089
680646002509	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098
680646002510	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
680646002511	2-isopropylmalate synthase; Validated; Region: PRK03739
680646002512	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
680646002513	active site
680646002514	catalytic residues [active]
680646002515	metal binding site [ion binding]; metal-binding site
680646002516	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
680646002517	Bacitracin resistance protein BacA; Region: BacA; cl00858
680646002518	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
680646002519	cysteinyl-tRNA synthetase; Provisional; Region: PRK12418
680646002520	active site
680646002521	HIGH motif; other site
680646002522	nucleotide binding site [chemical binding]; other site
680646002523	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
680646002524	active site
680646002525	KMSKS motif; other site
680646002526	potential protein location (hypothetical protein) that overlaps protein (tRNA(1-methyladenosine) methyltransferase)
680646002527	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
680646002528	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
680646002529	S-adenosylmethionine binding site [chemical binding]; other site
680646002530	proteasome ATPase; Region: pup_AAA; TIGR03689
680646002531	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
680646002532	Walker A motif; other site
680646002533	ATP binding site [chemical binding]; other site
680646002534	Walker B motif; other site
680646002535	arginine finger; other site
680646002536	proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688
680646002537	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
680646002538	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
680646002539	proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686
680646002540	proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688
680646002541	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
680646002542	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
680646002543	Predicted transcriptional regulator [Transcription]; Region: COG2378
680646002544	Predicted transcriptional regulator [Transcription]; Region: COG2378
680646002545	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
680646002546	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
680646002547	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
680646002548	ATP binding site [chemical binding]; other site
680646002549	putative Mg++ binding site [ion binding]; other site
680646002550	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
680646002551	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
680646002552	nucleotide binding region [chemical binding]; other site
680646002553	ATP-binding site [chemical binding]; other site
680646002554	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
680646002555	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
680646002556	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
680646002557	Ligand binding site [chemical binding]; other site
680646002558	Putative Catalytic site [active]
680646002559	DXD motif; other site
680646002560	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
680646002561	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
680646002562	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
680646002563	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
680646002564	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
680646002565	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
680646002566	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
680646002567	active site
680646002568	metal binding site [ion binding]; metal-binding site
680646002569	dimer interface [polypeptide binding]; other site
680646002570	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
680646002571	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_2_like; cd04738
680646002572	quinone interaction residues [chemical binding]; other site
680646002573	Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167
680646002574	active site
680646002575	catalytic residues [active]
680646002576	FMN binding site [chemical binding]; other site
680646002577	substrate binding site [chemical binding]; other site
680646002578	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
680646002579	catalytic residue [active]
680646002580	putative FPP diphosphate  binding site; other site
680646002581	putative FPP binding hydrophobic cleft; other site
680646002582	dimer interface [polypeptide binding]; other site
680646002583	putative IPP diphosphate binding site; other site
680646002584	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
680646002585	Recombination protein O N terminal; Region: RecO_N; pfam11967
680646002586	Recombination protein O C terminal; Region: RecO_C; pfam02565
680646002587	potential protein location (hypothetical protein) that overlaps protein (dehydrogenase)
680646002588	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
680646002589	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
680646002590	NAD binding site [chemical binding]; other site
680646002591	dimer interface [polypeptide binding]; other site
680646002592	substrate binding site [chemical binding]; other site
680646002593	tetramer (dimer of dimers) interface [polypeptide binding]; other site
680646002594	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
680646002595	amidohydrolase; Region: amidohydrolases; TIGR01891
680646002596	metal binding site [ion binding]; metal-binding site
680646002597	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
680646002598	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
680646002599	putative NAD(P) binding site [chemical binding]; other site
680646002600	catalytic Zn binding site [ion binding]; other site
680646002601	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
680646002602	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
680646002603	Zn binding site [ion binding]; other site
680646002604	Domain of unknown function (DUF3358); Region: DUF3358; pfam11838
680646002605	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
680646002606	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
680646002607	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
680646002608	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
680646002609	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
680646002610	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This...; Region: ABC_cobalt_CbiO_domain1; cd03225
680646002611	Walker A/P-loop; other site
680646002612	ATP binding site [chemical binding]; other site
680646002613	Q-loop/lid; other site
680646002614	ABC transporter signature motif; other site
680646002615	Walker B; other site
680646002616	D-loop; other site
680646002617	H-loop/switch region; other site
680646002618	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
680646002619	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
680646002620	potential protein location (hypothetical protein) that overlaps protein (dehydrogenase)
680646002621	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
680646002622	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
680646002623	NAD(P) binding site [chemical binding]; other site
680646002624	homotetramer interface [polypeptide binding]; other site
680646002625	homodimer interface [polypeptide binding]; other site
680646002626	active site
680646002627	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
680646002628	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646002629	Walker A/P-loop; other site
680646002630	ATP binding site [chemical binding]; other site
680646002631	Q-loop/lid; other site
680646002632	ABC transporter signature motif; other site
680646002633	Walker B; other site
680646002634	D-loop; other site
680646002635	H-loop/switch region; other site
680646002636	ABC transporter; Region: ABC_tran_2; pfam12848
680646002637	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
680646002638	BioY family; Region: BioY; cl00560
680646002639	K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927
680646002640	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
680646002641	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This...; Region: ABC_cobalt_CbiO_domain1; cd03225
680646002642	Walker A/P-loop; other site
680646002643	ATP binding site [chemical binding]; other site
680646002644	Q-loop/lid; other site
680646002645	ABC transporter signature motif; other site
680646002646	Walker B; other site
680646002647	D-loop; other site
680646002648	H-loop/switch region; other site
680646002649	(p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691
680646002650	Domain of unknown function DUF59; Region: DUF59; cl00941
680646002651	FeS assembly ATPase SufC; Region: sufC; TIGR01978
680646002652	ABC-type transport system involved in Fe-S cluster assembly, ATPase component.  Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems.  The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217
680646002653	Walker A/P-loop; other site
680646002654	ATP binding site [chemical binding]; other site
680646002655	Q-loop/lid; other site
680646002656	ABC transporter signature motif; other site
680646002657	Walker B; other site
680646002658	D-loop; other site
680646002659	H-loop/switch region; other site
680646002660	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
680646002661	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
680646002662	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
680646002663	FeS assembly protein SufB; Region: sufB; TIGR01980
680646002664	Predicted transcriptional regulator [Transcription]; Region: COG2345
680646002665	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
680646002666	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
680646002667	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
680646002668	Walker A/P-loop; other site
680646002669	ATP binding site [chemical binding]; other site
680646002670	Q-loop/lid; other site
680646002671	ABC transporter signature motif; other site
680646002672	Walker B; other site
680646002673	D-loop; other site
680646002674	H-loop/switch region; other site
680646002675	ABC-2 type transporter; Region: ABC2_membrane; cl11417
680646002676	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
680646002677	transketolase; Reviewed; Region: PRK05899
680646002678	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
680646002679	TPP-binding site [chemical binding]; other site
680646002680	dimer interface [polypeptide binding]; other site
680646002681	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
680646002682	PYR/PP interface [polypeptide binding]; other site
680646002683	dimer interface [polypeptide binding]; other site
680646002684	TPP binding site [chemical binding]; other site
680646002685	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
680646002686	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
680646002687	putative active site [active]
680646002688	transaldolase; Provisional; Region: PRK03903
680646002689	catalytic residue [active]
680646002690	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
680646002691	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
680646002692	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
680646002693	opcA protein; Region: OpcA; TIGR00534
680646002694	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359
680646002695	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
680646002696	active site
680646002697	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
680646002698	putative active site [active]
680646002699	Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691
680646002700	HicB family; Region: HicB; pfam05534
680646002701	Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691
680646002702	HicB family; Region: HicB; pfam05534
680646002703	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
680646002704	putative metal binding site [ion binding]; other site
680646002705	potential frameshift: common BLAST hit: gi|256390386|ref|YP_003111950.1| zinc finger SWIM domain protein
680646002706	SWIM zinc finger; Region: SWIM; cl11618
680646002707	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
680646002708	substrate binding site [chemical binding]; other site
680646002709	dimer interface [polypeptide binding]; other site
680646002710	catalytic triad [active]
680646002711	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
680646002712	RHS Repeat; Region: RHS_repeat; cl11982
680646002713	RHS Repeat; Region: RHS_repeat; cl11982
680646002714	RHS Repeat; Region: RHS_repeat; cl11982
680646002715	RHS Repeat; Region: RHS_repeat; cl11982
680646002716	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
680646002717	RHS Repeat; Region: RHS_repeat; cl11982
680646002718	RHS Repeat; Region: RHS_repeat; cl11982
680646002719	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
680646002720	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883
680646002721	nucleophilic elbow; other site
680646002722	catalytic triad; other site
680646002723	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
680646002724	substrate binding site [chemical binding]; other site
680646002725	hinge regions; other site
680646002726	ADP binding site [chemical binding]; other site
680646002727	catalytic site [active]
680646002728	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
680646002729	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
680646002730	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
680646002731	Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577
680646002732	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
680646002733	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
680646002734	HIGH motif; other site
680646002735	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
680646002736	active site
680646002737	KMSKS motif; other site
680646002738	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
680646002739	tRNA binding surface [nucleotide binding]; other site
680646002740	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
680646002741	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
680646002742	potential protein location (hypothetical protein) that overlaps protein (primosomal protein N' - superfamily II helicase)
680646002743	primosome assembly protein PriA; Provisional; Region: PRK14873
680646002744	primosome assembly protein PriA; Provisional; Region: PRK14873
680646002745	S-adenosylmethionine synthetase; Validated; Region: PRK05250
680646002746	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
680646002747	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
680646002748	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
680646002749	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
680646002750	GIY-YIG catalytic domain; Region: GIY-YIG; cl01061
680646002751	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
680646002752	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
680646002753	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
680646002754	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
680646002755	putative acyl-acceptor binding pocket; other site
680646002756	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily...; Region: Heme_Cu_Oxidase_I; cl00275
680646002757	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
680646002758	multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713
680646002759	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
680646002760	dimer interface [polypeptide binding]; other site
680646002761	substrate binding site [chemical binding]; other site
680646002762	ATP binding site [chemical binding]; other site
680646002763	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243
680646002764	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
680646002765	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
680646002766	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646002767	Walker A/P-loop; other site
680646002768	ATP binding site [chemical binding]; other site
680646002769	Q-loop/lid; other site
680646002770	ABC transporter signature motif; other site
680646002771	Walker B; other site
680646002772	D-loop; other site
680646002773	H-loop/switch region; other site
680646002774	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
680646002775	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646002776	Walker A/P-loop; other site
680646002777	ATP binding site [chemical binding]; other site
680646002778	Q-loop/lid; other site
680646002779	ABC transporter signature motif; other site
680646002780	Walker B; other site
680646002781	D-loop; other site
680646002782	ATP-dependent helicase; Provisional; Region: PRK13767
680646002783	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
680646002784	ATP binding site [chemical binding]; other site
680646002785	putative Mg++ binding site [ion binding]; other site
680646002786	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
680646002787	nucleotide binding region [chemical binding]; other site
680646002788	ATP-binding site [chemical binding]; other site
680646002789	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
680646002790	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
680646002791	Integral membrane protein TerC family; Region: TerC; cl10468
680646002792	Protein of unknown function (DUF812); Region: DUF812; pfam05667
680646002793	excinuclease ABC subunit B; Provisional; Region: PRK05298
680646002794	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
680646002795	nucleotide binding region [chemical binding]; other site
680646002796	ATP-binding site [chemical binding]; other site
680646002797	Ultra-violet resistance protein B; Region: UvrB; pfam12344
680646002798	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
680646002799	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
680646002800	ABC-ATPase subunit  interface; other site
680646002801	dimer interface [polypeptide binding]; other site
680646002802	putative PBP binding regions; other site
680646002803	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
680646002804	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235
680646002805	Periplasmic binding protein TroA_e.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142
680646002806	putative ligand binding residues [chemical binding]; other site
680646002807	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
680646002808	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
680646002809	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
680646002810	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
680646002811	CoA-binding site [chemical binding]; other site
680646002812	ATP-binding [chemical binding]; other site
680646002813	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
680646002814	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
680646002815	RNA binding site [nucleotide binding]; other site
680646002816	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
680646002817	RNA binding site [nucleotide binding]; other site
680646002818	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927
680646002819	RNA binding site [nucleotide binding]; other site
680646002820	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472
680646002821	RNA binding site [nucleotide binding]; other site
680646002822	domain interface; other site
680646002823	5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739
680646002824	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
680646002825	active site
680646002826	metal binding site 1 [ion binding]; metal-binding site
680646002827	putative 5' ssDNA interaction site; other site
680646002828	metal binding site 3; metal-binding site
680646002829	metal binding site 2 [ion binding]; metal-binding site
680646002830	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
680646002831	putative DNA binding site [nucleotide binding]; other site
680646002832	putative metal binding site [ion binding]; other site
680646002833	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
680646002834	active site
680646002835	substrate binding site [chemical binding]; other site
680646002836	catalytic site [active]
680646002837	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
680646002838	active site
680646002839	DNA binding site [nucleotide binding]
680646002840	catalytic site [active]
680646002841	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
680646002842	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
680646002843	CoenzymeA binding site [chemical binding]; other site
680646002844	subunit interaction site [polypeptide binding]; other site
680646002845	PHB binding site; other site
680646002846	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
680646002847	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
680646002848	active site
680646002849	phosphorylation site [posttranslational modification]
680646002850	intermolecular recognition site; other site
680646002851	dimerization interface [polypeptide binding]; other site
680646002852	ANTAR domain; Region: ANTAR; pfam03861
680646002853	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
680646002854	Major Facilitator Superfamily; Region: MFS_1; pfam07690
680646002855	putative substrate translocation pore; other site
680646002856	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
680646002857	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
680646002858	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
680646002859	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
680646002860	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
680646002861	active site
680646002862	ribulose/triose binding site [chemical binding]; other site
680646002863	phosphate binding site [ion binding]; other site
680646002864	substrate (anthranilate) binding pocket [chemical binding]; other site
680646002865	product (indole) binding pocket [chemical binding]; other site
680646002866	anthranilate synthase component I; Provisional; Region: PRK13571
680646002867	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
680646002868	chorismate binding enzyme; Region: Chorismate_bind; cl10555
680646002869	potential protein location (hypothetical protein) that overlaps protein (riboflavin synthase beta-chain)
680646002870	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
680646002871	homopentamer interface [polypeptide binding]; other site
680646002872	active site
680646002873	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
680646002874	GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807
680646002875	dimerization interface [polypeptide binding]; other site
680646002876	active site
680646002877	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
680646002878	Lumazine binding domain; Region: Lum_binding; pfam00677
680646002879	Lumazine binding domain; Region: Lum_binding; pfam00677
680646002880	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
680646002881	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
680646002882	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
680646002883	catalytic motif [active]
680646002884	Zn binding site [ion binding]; other site
680646002885	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161
680646002886	Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256
680646002887	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
680646002888	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
680646002889	dimer interface [polypeptide binding]; other site
680646002890	active site
680646002891	Phosphopantetheine attachment site; Region: PP-binding; cl09936
680646002892	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
680646002893	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
680646002894	dimer interface [polypeptide binding]; other site
680646002895	active site
680646002896	CoA binding pocket [chemical binding]; other site
680646002897	Acyl transferase domain; Region: Acyl_transf_1; cl08282
680646002898	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
680646002899	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
680646002900	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
680646002901	DNA binding site [nucleotide binding]
680646002902	Int/Topo IB signature motif; other site
680646002903	active site
680646002904	DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695
680646002905	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
680646002906	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
680646002907	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646002908	Uncharacterised protein family UPF0102; Region: UPF0102; cl00516
680646002909	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
680646002910	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
680646002911	RNA/DNA hybrid binding site [nucleotide binding]; other site
680646002912	active site
680646002913	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
680646002914	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
680646002915	Catalytic site [active]
680646002916	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
680646002917	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
680646002918	dimer interface [polypeptide binding]; other site
680646002919	ssDNA binding site [nucleotide binding]; other site
680646002920	tetramer (dimer of dimers) interface [polypeptide binding]; other site
680646002921	Domain of unknown function (DUF1994); Region: DUF1994; pfam09352
680646002922	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
680646002923	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
680646002924	putative active site [active]
680646002925	putative substrate binding site [chemical binding]; other site
680646002926	catalytic site [active]
680646002927	dimer interface [polypeptide binding]; other site
680646002928	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487
680646002929	active site
680646002930	catalytic residues [active]
680646002931	metal binding site [ion binding]; metal-binding site
680646002932	Protein of unknown function (DUF328); Region: DUF328; cl01143
680646002933	S-layer homology domain; Region: SLH; pfam00395
680646002934	S-layer homology domain; Region: SLH; pfam00395
680646002935	potential protein location (hypothetical protein) that overlaps protein (predicted nucleic acid-binding protein)
680646002936	S-layer homology domain; Region: SLH; pfam00395
680646002937	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309
680646002938	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
680646002939	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567
680646002940	structural tetrad; other site
680646002941	Uncharacterized conserved protein [Function unknown]; Region: COG3391
680646002942	Uncharacterized conserved protein [Function unknown]; Region: COG3391
680646002943	S-layer homology domain; Region: SLH; pfam00395
680646002944	S-layer homology domain; Region: SLH; pfam00395
680646002945	CRISPR/Cas system-associated RAMP superfamily protein Csb3; Region: Csb3_I-U; cd09764
680646002946	CRISPR-associated helicase Cas3, subtype Dpsyc; Region: cas3_GSU0051; TIGR02621
680646002947	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882
680646002948	CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827
680646002949	CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834
680646002950	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
680646002951	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
680646002952	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
680646002953	AFG1-like ATPase; Region: AFG1_ATPase; pfam03969
680646002954	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646002955	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
680646002956	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS); Region: YbaK_deacylase; cd00002
680646002957	putative deacylase active site [active]
680646002958	SelR domain; Region: SelR; cl00369
680646002959	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
680646002960	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
680646002961	putative active site [active]
680646002962	catalytic site [active]
680646002963	putative substrate binding site [chemical binding]; other site
680646002964	HRDC domain; Region: HRDC; cl02578
680646002965	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
680646002966	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467
680646002967	iron-sulfur cluster [ion binding]; other site
680646002968	[2Fe-2S] cluster binding site [ion binding]; other site
680646002969	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
680646002970	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629
680646002971	TPP-binding site [chemical binding]; other site
680646002972	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629
680646002973	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
680646002974	PYR/PP interface [polypeptide binding]; other site
680646002975	dimer interface [polypeptide binding]; other site
680646002976	TPP binding site [chemical binding]; other site
680646002977	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
680646002978	TRAM domain; Region: TRAM; cl01282
680646002979	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
680646002980	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
680646002981	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
680646002982	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
680646002983	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
680646002984	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
680646002985	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
680646002986	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
680646002987	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
680646002988	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
680646002989	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
680646002990	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
680646002991	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
680646002992	trimer interface [polypeptide binding]; other site
680646002993	active site
680646002994	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
680646002995	Sulfatase; Region: Sulfatase; cl10460
680646002996	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
680646002997	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187
680646002998	CAP-like domain; other site
680646002999	Active site [active]
680646003000	primary dimer interface [polypeptide binding]; other site
680646003001	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
680646003002	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
680646003003	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
680646003004	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
680646003005	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646003006	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
680646003007	Walker A/P-loop; other site
680646003008	ATP binding site [chemical binding]; other site
680646003009	Q-loop/lid; other site
680646003010	ABC transporter signature motif; other site
680646003011	Walker B; other site
680646003012	D-loop; other site
680646003013	H-loop/switch region; other site
680646003014	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
680646003015	The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export.  They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins.  The ABCC subfamily contains transporters with...; Region: ABCC_MRP_Like; cd03228
680646003016	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
680646003017	Walker A/P-loop; other site
680646003018	ATP binding site [chemical binding]; other site
680646003019	Q-loop/lid; other site
680646003020	ABC transporter signature motif; other site
680646003021	Walker B; other site
680646003022	D-loop; other site
680646003023	H-loop/switch region; other site
680646003024	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
680646003025	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
680646003026	Walker A/P-loop; other site
680646003027	ATP binding site [chemical binding]; other site
680646003028	Q-loop/lid; other site
680646003029	ABC transporter signature motif; other site
680646003030	Walker B; other site
680646003031	D-loop; other site
680646003032	H-loop/switch region; other site
680646003033	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
680646003034	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
680646003035	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
680646003036	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
680646003037	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
680646003038	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
680646003039	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
680646003040	ATP binding site [chemical binding]; other site
680646003041	Mg2+ binding site [ion binding]; other site
680646003042	G-X-G motif; other site
680646003043	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822
680646003044	anchoring element; other site
680646003045	dimer interface [polypeptide binding]; other site
680646003046	ATP binding site [chemical binding]; other site
680646003047	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
680646003048	active site
680646003049	metal binding site [ion binding]; metal-binding site
680646003050	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
680646003051	RDD family; Region: RDD; cl00746
680646003052	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515
680646003053	active site
680646003054	dimerization interface [polypeptide binding]; other site
680646003055	ribonuclease PH; Reviewed; Region: rph; PRK00173
680646003056	3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
680646003057	3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725
680646003058	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
680646003059	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
680646003060	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
680646003061	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
680646003062	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
680646003063	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_A; cd01570
680646003064	active site
680646003065	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
680646003066	catalytic triad [active]
680646003067	metal binding site [ion binding]; metal-binding site
680646003068	conserved cis-peptide bond; other site
680646003069	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
680646003070	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
680646003071	ATP binding site [chemical binding]; other site
680646003072	putative Mg++ binding site [ion binding]; other site
680646003073	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882
680646003074	nucleotide binding region [chemical binding]; other site
680646003075	ATP-binding site [chemical binding]; other site
680646003076	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
680646003077	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
680646003078	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
680646003079	Walker A/P-loop; other site
680646003080	ATP binding site [chemical binding]; other site
680646003081	Q-loop/lid; other site
680646003082	ABC transporter signature motif; other site
680646003083	Walker B; other site
680646003084	D-loop; other site
680646003085	H-loop/switch region; other site
680646003086	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
680646003087	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
680646003088	Domain of unknown function DUF20; Region: UPF0118; cl00465
680646003089	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
680646003090	Protein of unknown function DUF91; Region: DUF91; cl00709
680646003091	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
680646003092	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
680646003093	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
680646003094	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
680646003095	alpha subunit interaction interface [polypeptide binding]; other site
680646003096	Walker A motif; other site
680646003097	ATP binding site [chemical binding]; other site
680646003098	Walker B motif; other site
680646003099	inhibitor binding site; inhibition site
680646003100	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
680646003101	ATP synthase; Region: ATP-synt; cl00365
680646003102	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
680646003103	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
680646003104	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
680646003105	beta subunit interaction interface [polypeptide binding]; other site
680646003106	Walker A motif; other site
680646003107	ATP binding site [chemical binding]; other site
680646003108	Walker B motif; other site
680646003109	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
680646003110	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
680646003111	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
680646003112	potential protein location (hypothetical protein) that overlaps protein (F0F1-type ATP synthase, delta subunit)
680646003113	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
680646003114	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
680646003115	ATP synthase subunit C; Region: ATP-synt_C; cl00466
680646003116	ATP synthase A chain; Region: ATP-synt_A; cl00413
680646003117	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
680646003118	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine...; Region: GT_WbpL_WbcO_like; cd06854
680646003119	Mg++ binding site [ion binding]; other site
680646003120	putative catalytic motif [active]
680646003121	putative substrate binding site [chemical binding]; other site
680646003122	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
680646003123	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
680646003124	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
680646003125	NAD(P) binding site [chemical binding]; other site
680646003126	homodimer interface [polypeptide binding]; other site
680646003127	substrate binding site [chemical binding]; other site
680646003128	active site
680646003129	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
680646003130	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185
680646003131	Probable Catalytic site [active]
680646003132	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
680646003133	active site
680646003134	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
680646003135	NAD(P) binding site [chemical binding]; other site
680646003136	active site
680646003137	potential protein location (hypothetical protein) that overlaps protein (putative translation factor)
680646003138	yrdC domain; Region: Sua5_yciO_yrdC; cl00305
680646003139	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
680646003140	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
680646003141	S-adenosylmethionine binding site [chemical binding]; other site
680646003142	peptide chain release factor 1; Validated; Region: prfA; PRK00591
680646003143	RF-1 domain; Region: RF-1; cl02875
680646003144	RF-1 domain; Region: RF-1; cl02875
680646003145	potential protein location (hypothetical protein) that overlaps protein (transcription termination factor)
680646003146	transcription termination factor Rho; Provisional; Region: PRK12678
680646003147	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
680646003148	transcription termination factor Rho; Provisional; Region: rho; PRK09376
680646003149	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459
680646003150	RNA binding site [nucleotide binding]; other site
680646003151	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128
680646003152	multimer interface [polypeptide binding]; other site
680646003153	Walker A motif; other site
680646003154	ATP binding site [chemical binding]; other site
680646003155	Walker B motif; other site
680646003156	homoserine kinase; Provisional; Region: PRK01212
680646003157	threonine synthase; Reviewed; Region: PRK06721
680646003158	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563
680646003159	homodimer interface [polypeptide binding]; other site
680646003160	pyridoxal 5'-phosphate binding site [chemical binding]; other site
680646003161	catalytic residue [active]
680646003162	homoserine dehydrogenase; Provisional; Region: PRK06349
680646003163	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
680646003164	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
680646003165	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
680646003166	diaminopimelate decarboxylase; Region: lysA; TIGR01048
680646003167	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
680646003168	active site
680646003169	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
680646003170	substrate binding site [chemical binding]; other site
680646003171	catalytic residues [active]
680646003172	dimer interface [polypeptide binding]; other site
680646003173	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
680646003174	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
680646003175	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
680646003176	active site
680646003177	HIGH motif; other site
680646003178	KMSK motif region; other site
680646003179	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
680646003180	tRNA binding surface [nucleotide binding]; other site
680646003181	anticodon binding site; other site
680646003182	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
680646003183	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
680646003184	putative NAD(P) binding site [chemical binding]; other site
680646003185	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
680646003186	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
680646003187	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
680646003188	DNA binding residues [nucleotide binding]
680646003189	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
680646003190	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
680646003191	ATP binding site [chemical binding]; other site
680646003192	putative Mg++ binding site [ion binding]; other site
680646003193	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882
680646003194	Helicase associated domain (HA2); Region: HA2; cl04503
680646003195	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
680646003196	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
680646003197	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085
680646003198	active site
680646003199	potential protein location (hypothetical protein) that overlaps protein (restriction endonuclease)
680646003200	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
680646003201	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
680646003202	metal binding triad; other site
680646003203	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
680646003204	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
680646003205	metal binding triad; other site
680646003206	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
680646003207	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
680646003208	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
680646003209	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
680646003210	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
680646003211	active site
680646003212	oligomerization interface [polypeptide binding]; other site
680646003213	metal binding site [ion binding]; metal-binding site
680646003214	methionine aminopeptidase; Reviewed; Region: PRK07281
680646003215	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
680646003216	active site
680646003217	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
680646003218	fructokinase; Reviewed; Region: PRK09557
680646003219	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
680646003220	ATP cone domain; Region: ATP-cone; pfam03477
680646003221	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
680646003222	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
680646003223	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
680646003224	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485
680646003225	generic binding surface II; other site
680646003226	generic binding surface I; other site
680646003227	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
680646003228	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
680646003229	active site
680646003230	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
680646003231	DivIVA domain; Region: DivI1A_domain; TIGR03544
680646003232	Protein of unknown function (DUF552); Region: DUF552; cl00775
680646003233	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
680646003234	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
680646003235	catalytic residue [active]
680646003236	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
680646003237	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
680646003238	potential protein location (hypothetical protein) that overlaps protein (cell division GTPase)
680646003239	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201
680646003240	nucleotide binding site [chemical binding]; other site
680646003241	SulA interaction site; other site
680646003242	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
680646003243	Cell division protein FtsQ; Region: FtsQ; pfam03799
680646003244	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
680646003245	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
680646003246	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
680646003247	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
680646003248	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
680646003249	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785
680646003250	active site
680646003251	homodimer interface [polypeptide binding]; other site
680646003252	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
680646003253	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438
680646003254	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
680646003255	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
680646003256	phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445
680646003257	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852
680646003258	Mg++ binding site [ion binding]; other site
680646003259	putative catalytic motif [active]
680646003260	putative substrate binding site [chemical binding]; other site
680646003261	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
680646003262	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
680646003263	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
680646003264	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
680646003265	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
680646003266	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
680646003267	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
680646003268	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
680646003269	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
680646003270	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
680646003271	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
680646003272	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
680646003273	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
680646003274	cell division protein MraZ; Reviewed; Region: PRK00326
680646003275	MraZ protein; Region: MraZ; pfam02381
680646003276	MraZ protein; Region: MraZ; pfam02381
680646003277	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
680646003278	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
680646003279	active site
680646003280	DNA polymerase IV; Validated; Region: PRK02406
680646003281	DNA binding site [nucleotide binding]
680646003282	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
680646003283	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
680646003284	substrate binding pocket [chemical binding]; other site
680646003285	chain length determination region; other site
680646003286	substrate-Mg2+ binding site; other site
680646003287	catalytic residues [active]
680646003288	aspartate-rich region 1; other site
680646003289	active site lid residues [active]
680646003290	aspartate-rich region 2; other site
680646003291	Catalytic domain of Protein Kinases; Region: PKc; cd00180
680646003292	active site
680646003293	ATP binding site [chemical binding]; other site
680646003294	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
680646003295	substrate binding site [chemical binding]; other site
680646003296	activation loop (A-loop); other site
680646003297	Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230
680646003298	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
680646003299	putative acyl-acceptor binding pocket; other site
680646003300	Esterase/lipase [General function prediction only]; Region: COG1647
680646003301	Protein of unknown function (DUF3530); Region: DUF3530; pfam12048
680646003302	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
680646003303	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
680646003304	mycothione reductase; Reviewed; Region: PRK07846
680646003305	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
680646003306	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
680646003307	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
680646003308	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
680646003309	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
680646003310	Magnesium ion binding site [ion binding]; other site
680646003311	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
680646003312	DNA binding residues [nucleotide binding]
680646003313	putative dimer interface [polypeptide binding]; other site
680646003314	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
680646003315	DNA binding residues [nucleotide binding]
680646003316	dimer interface [polypeptide binding]; other site
680646003317	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848
680646003318	lipoyl attachment site [posttranslational modification]; other site
680646003319	Proline dehydrogenase; Region: Pro_dh; cl03282
680646003320	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
680646003321	NAD(P) binding site [chemical binding]; other site
680646003322	catalytic residues [active]
680646003323	Transcriptional regulator [Transcription]; Region: LysR; COG0583
680646003324	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
680646003325	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
680646003326	putative dimerization interface [polypeptide binding]; other site
680646003327	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
680646003328	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055
680646003329	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
680646003330	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
680646003331	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cl00200
680646003332	amphipathic channel; other site
680646003333	Asn-Pro-Ala signature motifs; other site
680646003334	glycerol kinase; Provisional; Region: glpK; PRK00047
680646003335	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
680646003336	FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782
680646003337	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
680646003338	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
680646003339	DNA binding site [nucleotide binding]
680646003340	active site
680646003341	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
680646003342	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
680646003343	Protein of unknown function (DUF1304); Region: DUF1304; cl01533
680646003344	glycolate transporter; Provisional; Region: PRK09695
680646003345	L-lactate permease; Region: Lactate_perm; cl00701
680646003346	glycolate transporter; Provisional; Region: PRK09695
680646003347	L-lactate permease; Region: Lactate_perm; cl00701
680646003348	GTP-binding protein Der; Reviewed; Region: PRK03003
680646003349	EngA1 subfamily.  This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains.  Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894
680646003350	G1 box; other site
680646003351	GTP/Mg2+ binding site [chemical binding]; other site
680646003352	Switch I region; other site
680646003353	G2 box; other site
680646003354	Switch II region; other site
680646003355	G3 box; other site
680646003356	G4 box; other site
680646003357	G5 box; other site
680646003358	EngA2 subfamily.  This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains.  Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895
680646003359	G1 box; other site
680646003360	GTP/Mg2+ binding site [chemical binding]; other site
680646003361	Switch I region; other site
680646003362	G2 box; other site
680646003363	G3 box; other site
680646003364	Switch II region; other site
680646003365	G4 box; other site
680646003366	G5 box; other site
680646003367	cytidylate kinase; Provisional; Region: cmk; PRK00023
680646003368	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
680646003369	CMP-binding site; other site
680646003370	The sites determining sugar specificity; other site
680646003371	prephenate dehydrogenase; Validated; Region: PRK06545
680646003372	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
680646003373	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
680646003374	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
680646003375	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
680646003376	RNA binding surface [nucleotide binding]; other site
680646003377	Pseudouridine synthases  are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870
680646003378	active site
680646003379	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
680646003380	ScpA/B protein; Region: ScpA_ScpB; cl00598
680646003381	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
680646003382	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
680646003383	P-loop; other site
680646003384	Magnesium ion binding site [ion binding]; other site
680646003385	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
680646003386	Magnesium ion binding site [ion binding]; other site
680646003387	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
680646003388	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
680646003389	Phage integrase family; Region: Phage_integrase; pfam00589
680646003390	DNA binding site [nucleotide binding]
680646003391	Int/Topo IB signature motif; other site
680646003392	active site
680646003393	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424
680646003394	dimer interface [polypeptide binding]; other site
680646003395	ADP-ribose binding site [chemical binding]; other site
680646003396	active site
680646003397	nudix motif; other site
680646003398	metal binding site [ion binding]; metal-binding site
680646003399	CTP synthetase; Validated; Region: pyrG; PRK05380
680646003400	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113
680646003401	Catalytic site [active]
680646003402	Active site [active]
680646003403	UTP binding site [chemical binding]; other site
680646003404	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
680646003405	active site
680646003406	putative oxyanion hole; other site
680646003407	catalytic triad [active]
680646003408	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
680646003409	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241
680646003410	Walker A/P-loop; other site
680646003411	ATP binding site [chemical binding]; other site
680646003412	Q-loop/lid; other site
680646003413	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241
680646003414	ABC transporter signature motif; other site
680646003415	Walker B; other site
680646003416	D-loop; other site
680646003417	H-loop/switch region; other site
680646003418	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
680646003419	ATP-NAD kinase; Region: NAD_kinase; pfam01513
680646003420	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
680646003421	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
680646003422	RNA binding surface [nucleotide binding]; other site
680646003423	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
680646003424	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
680646003425	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
680646003426	active site
680646003427	motif I; other site
680646003428	motif II; other site
680646003429	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
680646003430	potential protein location (hypothetical protein) that overlaps protein (tyrosyl-tRNA synthetase)
680646003431	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
680646003432	active site
680646003433	KMSKS motif; other site
680646003434	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
680646003435	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
680646003436	UvrD/REP helicase; Region: UvrD-helicase; cl14126
680646003437	UvrD/REP helicase; Region: UvrD-helicase; cl14126
680646003438	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
680646003439	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
680646003440	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
680646003441	arginine repressor; Provisional; Region: PRK03341
680646003442	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
680646003443	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
680646003444	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
680646003445	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
680646003446	putative tRNA-binding site [nucleotide binding]; other site
680646003447	B3/4 domain; Region: B3_4; cl11458
680646003448	tRNA synthetase B5 domain; Region: B5; cl08394
680646003449	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
680646003450	dimer interface [polypeptide binding]; other site
680646003451	motif 1; other site
680646003452	motif 3; other site
680646003453	motif 2; other site
680646003454	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
680646003455	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
680646003456	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
680646003457	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
680646003458	dimer interface [polypeptide binding]; other site
680646003459	motif 1; other site
680646003460	active site
680646003461	motif 2; other site
680646003462	motif 3; other site
680646003463	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
680646003464	potential protein location (hypothetical protein) that overlaps protein (predicted periplasmic lipoprotein involved in iron transport)
680646003465	Imelysin; Region: Peptidase_M75; cl09159
680646003466	Iron permease FTR1 family; Region: FTR1; cl00475
680646003467	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
680646003468	active site
680646003469	8-oxo-dGMP binding site [chemical binding]; other site
680646003470	nudix motif; other site
680646003471	metal binding site [ion binding]; metal-binding site
680646003472	Protein of unknown function (DUF421); Region: DUF421; cl00990
680646003473	Cation efflux family; Region: Cation_efflux; cl00316
680646003474	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
680646003475	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
680646003476	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
680646003477	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
680646003478	23S rRNA binding site [nucleotide binding]; other site
680646003479	L21 binding site [polypeptide binding]; other site
680646003480	L13 binding site [polypeptide binding]; other site
680646003481	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
680646003482	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
680646003483	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
680646003484	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
680646003485	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106
680646003486	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732
680646003487	catalytic residues [active]
680646003488	imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; Region: IMP_synth_hisH; TIGR01855
680646003489	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
680646003490	conserved cys residue [active]
680646003491	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107
680646003492	LexA repressor; Validated; Region: PRK00215
680646003493	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
680646003494	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529
680646003495	Catalytic site [active]
680646003496	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
680646003497	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl09250
680646003498	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl09250
680646003499	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
680646003500	HflX subfamily.  A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily.  The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878
680646003501	G1 box; other site
680646003502	GTP/Mg2+ binding site [chemical binding]; other site
680646003503	Switch I region; other site
680646003504	G2 box; other site
680646003505	G3 box; other site
680646003506	Switch II region; other site
680646003507	G4 box; other site
680646003508	G5 box; other site
680646003509	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
680646003510	S-adenosylmethionine binding site [chemical binding]; other site
680646003511	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
680646003512	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
680646003513	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
680646003514	IPP transferase; Region: IPPT; cl00403
680646003515	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
680646003516	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
680646003517	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
680646003518	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
680646003519	FeS/SAM binding site; other site
680646003520	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
680646003521	RecX family; Region: RecX; cl00936
680646003522	recombinase A; Provisional; Region: recA; PRK09354
680646003523	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
680646003524	hexamer interface [polypeptide binding]; other site
680646003525	Walker A motif; other site
680646003526	ATP binding site [chemical binding]; other site
680646003527	Walker B motif; other site
680646003528	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
680646003529	potential protein location (hypothetical protein) that overlaps protein (predicted transcriptional regulator)
680646003530	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100
680646003531	Competence-damaged protein; Region: CinA; cl00666
680646003532	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
680646003533	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646003534	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
680646003535	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
680646003536	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
680646003537	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
680646003538	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
680646003539	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
680646003540	dimer interface [polypeptide binding]; other site
680646003541	active site
680646003542	catalytic residue [active]
680646003543	dihydrodipicolinate reductase; Provisional; Region: PRK00048
680646003544	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
680646003545	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
680646003546	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
680646003547	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
680646003548	active site
680646003549	catalytic triad [active]
680646003550	oxyanion hole [active]
680646003551	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
680646003552	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
680646003553	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
680646003554	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
680646003555	3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
680646003556	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
680646003557	3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
680646003558	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
680646003559	putative nucleic acid binding region [nucleotide binding]; other site
680646003560	G-X-X-G motif; other site
680646003561	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472
680646003562	RNA binding site [nucleotide binding]; other site
680646003563	domain interface; other site
680646003564	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353
680646003565	16S/18S rRNA binding site [nucleotide binding]; other site
680646003566	S13e-L30e interaction site [polypeptide binding]; other site
680646003567	25S rRNA binding site [nucleotide binding]; other site
680646003568	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
680646003569	Amino acid permease; Region: AA_permease; pfam00324
680646003570	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
680646003571	S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802
680646003572	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
680646003573	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
680646003574	active site
680646003575	Riboflavin kinase; Region: Flavokinase; pfam01687
680646003576	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
680646003577	PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573
680646003578	RNA binding site [nucleotide binding]; other site
680646003579	active site
680646003580	potential protein location (hypothetical protein) that overlaps protein (ribosome-binding factor A)
680646003581	Ribosome-binding factor A; Region: RBFA; cl00542
680646003582	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
680646003583	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
680646003584	translation initiation factor IF-2; Region: IF-2; TIGR00487
680646003585	IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily.  IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits.  As seen in other GTPases...; Region: IF2_eIF5B; cd01887
680646003586	G1 box; other site
680646003587	putative GEF interaction site [polypeptide binding]; other site
680646003588	GTP/Mg2+ binding site [chemical binding]; other site
680646003589	Switch I region; other site
680646003590	G2 box; other site
680646003591	G3 box; other site
680646003592	Switch II region; other site
680646003593	G4 box; other site
680646003594	G5 box; other site
680646003595	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702
680646003596	Translation-initiation factor 2; Region: IF-2; pfam11987
680646003597	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692
680646003598	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189
680646003599	putative RNA binding cleft [nucleotide binding]; other site
680646003600	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
680646003601	NusA N-terminal domain; Region: NusA_N; pfam08529
680646003602	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455
680646003603	RNA binding site [nucleotide binding]; other site
680646003604	homodimer interface [polypeptide binding]; other site
680646003605	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
680646003606	G-X-X-G motif; other site
680646003607	ribosome maturation protein RimP; Reviewed; Region: PRK00092
680646003608	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members...; Region: Sm_like; cl00259
680646003609	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members...; Region: Sm_like; cl00259
680646003610	Sm1 motif; other site
680646003611	D1 - D2 interaction site; other site
680646003612	D3 - B interaction site; other site
680646003613	Hfq - Hfq interaction site; other site
680646003614	RNA binding pocket [nucleotide binding]; other site
680646003615	Sm2 motif; other site
680646003616	prolyl-tRNA synthetase; Provisional; Region: PRK09194
680646003617	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779
680646003618	dimer interface [polypeptide binding]; other site
680646003619	motif 1; other site
680646003620	active site
680646003621	motif 2; other site
680646003622	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX.  The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
680646003623	putative deacylase active site [active]
680646003624	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
680646003625	active site
680646003626	motif 3; other site
680646003627	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible...; Region: HGTP_anticodon; cl00266
680646003628	anticodon binding site; other site
680646003629	Predicted acetyltransferase [General function prediction only]; Region: COG3393
680646003630	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
680646003631	1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612
680646003632	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
680646003633	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
680646003634	active site
680646003635	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989
680646003636	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
680646003637	putative substrate binding region [chemical binding]; other site
680646003638	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
680646003639	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
680646003640	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
680646003641	DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543
680646003642	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
680646003643	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
680646003644	hinge region; other site
680646003645	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254
680646003646	putative nucleotide binding site [chemical binding]; other site
680646003647	uridine monophosphate binding site [chemical binding]; other site
680646003648	homohexameric interface [polypeptide binding]; other site
680646003649	elongation factor Ts; Reviewed; Region: tsf; PRK12332
680646003650	Elongation factor TS; Region: EF_TS; pfam00889
680646003651	Elongation factor TS; Region: EF_TS; pfam00889
680646003652	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
680646003653	rRNA interaction site [nucleotide binding]; other site
680646003654	S8 interaction site; other site
680646003655	putative laminin-1 binding site; other site
680646003656	Peptidase family M23; Region: Peptidase_M23; pfam01551
680646003657	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
680646003658	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-...; Region: GT1_UGDG_like; cd03817
680646003659	putative ADP-binding pocket [chemical binding]; other site
680646003660	Protein of unknown function (DUF1469); Region: DUF1469; cl12095
680646003661	DNA primase, catalytic core; Region: dnaG; TIGR01391
680646003662	CHC2 zinc finger; Region: zf-CHC2; cl02597
680646003663	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
680646003664	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
680646003665	active site
680646003666	metal binding site [ion binding]; metal-binding site
680646003667	interdomain interaction site; other site
680646003668	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
680646003669	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
680646003670	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801
680646003671	FMN binding site [chemical binding]; other site
680646003672	active site
680646003673	catalytic residues [active]
680646003674	substrate binding site [chemical binding]; other site
680646003675	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
680646003676	Coenzyme A binding pocket [chemical binding]; other site
680646003677	glycyl-tRNA synthetase; Provisional; Region: PRK04173
680646003678	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
680646003679	motif 1; other site
680646003680	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the...; Region: GlyRS-like_core; cd00774
680646003681	active site
680646003682	motif 2; other site
680646003683	motif 3; other site
680646003684	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
680646003685	anticodon binding site; other site
680646003686	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
680646003687	RNA binding surface [nucleotide binding]; other site
680646003688	Predicted esterase [General function prediction only]; Region: COG0400
680646003689	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
680646003690	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
680646003691	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
680646003692	DNA binding residues [nucleotide binding]
680646003693	dimer interface [polypeptide binding]; other site
680646003694	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
680646003695	potential protein location (hypothetical protein) that overlaps protein (predicted transcriptional regulator)
680646003696	mercuric resistence transcriptional repressor protein MerD; Region: MerD; TIGR02054
680646003697	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
680646003698	DNA binding residues [nucleotide binding]
680646003699	putative dimer interface [polypeptide binding]; other site
680646003700	potential protein location (hypothetical protein) that overlaps protein (homoserine acetyltransferase)
680646003701	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
680646003702	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
680646003703	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812
680646003704	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
680646003705	homodimer interface [polypeptide binding]; other site
680646003706	substrate-cofactor binding pocket; other site
680646003707	pyridoxal 5'-phosphate binding site [chemical binding]; other site
680646003708	catalytic residue [active]
680646003709	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646003710	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
680646003711	ABC transporter signature motif; other site
680646003712	Walker B; other site
680646003713	D-loop; other site
680646003714	H-loop/switch region; other site
680646003715	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
680646003716	GTPase RsgA; Reviewed; Region: PRK01889
680646003717	YjeQ/EngC.  YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854
680646003718	GTPase/OB domain interface [polypeptide binding]; other site
680646003719	GTPase/Zn-binding domain interface [polypeptide binding]; other site
680646003720	GTP/Mg2+ binding site [chemical binding]; other site
680646003721	G4 box; other site
680646003722	G5 box; other site
680646003723	G1 box; other site
680646003724	Switch I region; other site
680646003725	G2 box; other site
680646003726	G3 box; other site
680646003727	Switch II region; other site
680646003728	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
680646003729	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
680646003730	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
680646003731	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
680646003732	GatB domain; Region: GatB_Yqey; cl11497
680646003733	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
680646003734	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
680646003735	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
680646003736	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
680646003737	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
680646003738	putative peptidoglycan binding site; other site
680646003739	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
680646003740	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
680646003741	nucleotide binding pocket [chemical binding]; other site
680646003742	K-X-D-G motif; other site
680646003743	catalytic site [active]
680646003744	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
680646003745	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
680646003746	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
680646003747	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cl00038
680646003748	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
680646003749	Protein phosphatase 2C; Region: PP2C; pfam00481
680646003750	Active site [active]
680646003751	cyclase homology domain; Region: CHD; cd07302
680646003752	nucleotidyl binding site; other site
680646003753	metal binding site [ion binding]; metal-binding site
680646003754	dimer interface [polypeptide binding]; other site
680646003755	potential protein location (hypothetical protein) that overlaps protein (ABC-type glucose/galactose transport system, permease component)
680646003756	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
680646003757	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
680646003758	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
680646003759	YCII-related domain; Region: YCII; cl00999
680646003760	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
680646003761	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513
680646003762	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513
680646003763	Restriction endonuclease; Region: Mrr_cat; cl00747
680646003764	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
680646003765	Glutathionylspermidine synthase; Region: GSP_synth; cl00503
680646003766	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
680646003767	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
680646003768	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
680646003769	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
680646003770	active site
680646003771	dimer interface [polypeptide binding]; other site
680646003772	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
680646003773	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
680646003774	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
680646003775	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
680646003776	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850
680646003777	carboxyltransferase (CT) interaction site; other site
680646003778	biotinylation site [posttranslational modification]; other site
680646003779	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
680646003780	metabolite-proton symporter; Region: 2A0106; TIGR00883
680646003781	putative substrate translocation pore; other site
680646003782	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
680646003783	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
680646003784	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
680646003785	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
680646003786	CarD-like/TRCF domain; Region: CarD_TRCF; cl00588
680646003787	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
680646003788	ATP binding site [chemical binding]; other site
680646003789	putative Mg++ binding site [ion binding]; other site
680646003790	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
680646003791	nucleotide binding region [chemical binding]; other site
680646003792	ATP-binding site [chemical binding]; other site
680646003793	TRCF domain; Region: TRCF; pfam03461
680646003794	Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085
680646003795	Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085
680646003796	Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085
680646003797	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
680646003798	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
680646003799	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
680646003800	active site
680646003801	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
680646003802	Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513
680646003803	Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513
680646003804	Glycosyltransferase family 28 N-terminal domain; Region: Glyco_transf_28; cl07328
680646003805	Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012
680646003806	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
680646003807	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
680646003808	active site
680646003809	nucleotide binding site [chemical binding]; other site
680646003810	HIGH motif; other site
680646003811	KMSKS motif; other site
680646003812	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
680646003813	trimerization site [polypeptide binding]; other site
680646003814	active site
680646003815	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
680646003816	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
680646003817	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
680646003818	catalytic residue [active]
680646003819	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
680646003820	putative active site [active]
680646003821	catalytic residue [active]
680646003822	Ribosomal_L25_TL5_CTC: Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain. L25 is a single-domain protein, homologous to the N-terminal domain of TL5 and CTC, which each contain two domains. CTC is a known stress protein, and proteins of this...; Region: Ribosomal_L25_TL5_CTC; cd00495
680646003823	5S rRNA interface [nucleotide binding]; other site
680646003824	CTC domain interface; other site
680646003825	L16 interface [polypeptide binding]; other site
680646003826	Cupin domain; Region: Cupin_2; cl09118
680646003827	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
680646003828	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
680646003829	NADP binding site [chemical binding]; other site
680646003830	active site
680646003831	putative substrate binding site [chemical binding]; other site
680646003832	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
680646003833	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
680646003834	NAD binding site [chemical binding]; other site
680646003835	substrate binding site [chemical binding]; other site
680646003836	homodimer interface [polypeptide binding]; other site
680646003837	active site
680646003838	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
680646003839	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
680646003840	substrate binding site [chemical binding]; other site
680646003841	tetramer interface [polypeptide binding]; other site
680646003842	Chain length determinant protein; Region: Wzz; cl01623
680646003843	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
680646003844	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
680646003845	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
680646003846	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
680646003847	putative ADP-binding pocket [chemical binding]; other site
680646003848	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
680646003849	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
680646003850	active site
680646003851	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
680646003852	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
680646003853	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
680646003854	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
680646003855	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
680646003856	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
680646003857	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607
680646003858	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
680646003859	NeuB family; Region: NeuB; cl00496
680646003860	SAF domain; Region: SAF; cl00555
680646003861	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
680646003862	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
680646003863	ligand binding site [chemical binding]; other site
680646003864	tetramer interface [polypeptide binding]; other site
680646003865	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-...; Region: LbH_MAT_like; cd04647
680646003866	trimer interface [polypeptide binding]; other site
680646003867	active site
680646003868	substrate binding site [chemical binding]; other site
680646003869	CoA binding site [chemical binding]; other site
680646003870	Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012
680646003871	potential protein location (hypothetical protein) that overlaps protein (predicted glycosyltransferase)
680646003872	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
680646003873	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
680646003874	active site
680646003875	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
680646003876	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
680646003877	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646003878	Walker A/P-loop; other site
680646003879	ATP binding site [chemical binding]; other site
680646003880	Q-loop/lid; other site
680646003881	ABC transporter signature motif; other site
680646003882	Walker B; other site
680646003883	D-loop; other site
680646003884	H-loop/switch region; other site
680646003885	Low molecular weight phosphatase family; Region: LMWPc; cl00105
680646003886	Active site [active]
680646003887	Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462
680646003888	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
680646003889	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
680646003890	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
680646003891	Substrate binding site [chemical binding]; other site
680646003892	Mg++ binding site [ion binding]; other site
680646003893	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
680646003894	active site
680646003895	substrate binding site [chemical binding]; other site
680646003896	CoA binding site [chemical binding]; other site
680646003897	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
680646003898	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
680646003899	ABC transporter; Region: ABC_tran_2; pfam12848
680646003900	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
680646003901	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
680646003902	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
680646003903	potential protein location (hypothetical protein) that overlaps protein (4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase)
680646003904	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
680646003905	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
680646003906	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
680646003907	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
680646003908	active site
680646003909	Predicted methyltransferases [General function prediction only]; Region: COG0313
680646003910	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
680646003911	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961
680646003912	Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928
680646003913	Protein of unknown function (DUF1461); Region: DUF1461; cl01862
680646003914	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
680646003915	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
680646003916	GtrA-like protein; Region: GtrA; cl00971
680646003917	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
680646003918	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
680646003919	AIR carboxylase; Region: AIRC; cl00310
680646003920	Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348
680646003921	FemAB family; Region: FemAB; cl11444
680646003922	FemAB family; Region: FemAB; cl11444
680646003923	Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins [Carbohydrate transport and metabolism]; Region: GlpX; COG1494
680646003924	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
680646003925	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
680646003926	active site clefts [active]
680646003927	zinc binding site [ion binding]; other site
680646003928	dimer interface [polypeptide binding]; other site
680646003929	fumarate hydratase; Reviewed; Region: fumC; PRK00485
680646003930	Class II fumarases; Region: Fumarase_classII; cd01362
680646003931	active site
680646003932	tetramer interface [polypeptide binding]; other site
680646003933	pyruvate dehydrogenase; Provisional; Region: PRK06546
680646003934	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
680646003935	PYR/PP interface [polypeptide binding]; other site
680646003936	tetramer interface [polypeptide binding]; other site
680646003937	dimer interface [polypeptide binding]; other site
680646003938	TPP binding site [chemical binding]; other site
680646003939	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
680646003940	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX...; Region: TPP_POX; cd02014
680646003941	TPP-binding site [chemical binding]; other site
680646003942	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
680646003943	nudix motif; other site
680646003944	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
680646003945	catalytic residue [active]
680646003946	putative FPP diphosphate  binding site; other site
680646003947	putative FPP binding hydrophobic cleft; other site
680646003948	dimer interface [polypeptide binding]; other site
680646003949	putative IPP diphosphate binding site; other site
680646003950	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
680646003951	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
680646003952	domain; Region: GreA_GreB_N; pfam03449
680646003953	C-term; Region: GreA_GreB; pfam01272
680646003954	threonine dehydratase; Provisional; Region: PRK08198
680646003955	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
680646003956	tetramer interface [polypeptide binding]; other site
680646003957	pyridoxal 5'-phosphate binding site [chemical binding]; other site
680646003958	catalytic residue [active]
680646003959	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
680646003960	Domain of unknown function DUF20; Region: UPF0118; cl00465
680646003961	BAX inhibitor (BI)-1 like protein family. Mammalian members of this family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well characterized oncogene, or...; Region: BI-1-like; cl00473
680646003962	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
680646003963	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
680646003964	active site
680646003965	motif I; other site
680646003966	motif II; other site
680646003967	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
680646003968	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
680646003969	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
680646003970	active site
680646003971	catalytic residues [active]
680646003972	exopolyphosphatase; Region: exo_poly_only; TIGR03706
680646003973	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
680646003974	Protein of unknown function (DUF501); Region: DUF501; cl00652
680646003975	Septum formation initiator; Region: DivIC; cl11433
680646003976	Core-2/I-Branching enzyme; Region: Branch; pfam02485
680646003977	enolase; Provisional; Region: eno; PRK00077
680646003978	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
680646003979	dimer interface [polypeptide binding]; other site
680646003980	metal binding site [ion binding]; metal-binding site
680646003981	substrate binding pocket [chemical binding]; other site
680646003982	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334
680646003983	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
680646003984	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
680646003985	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
680646003986	metal binding site [ion binding]; metal-binding site
680646003987	putative dimer interface [polypeptide binding]; other site
680646003988	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
680646003989	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
680646003990	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
680646003991	domain; Region: Succ_DH_flav_C; pfam02910
680646003992	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500
680646003993	putative Iron-sulfur protein interface [polypeptide binding]; other site
680646003994	putative proximal heme binding site [chemical binding]; other site
680646003995	putative SdhC-like subunit interface [polypeptide binding]; other site
680646003996	putative distal heme binding site [chemical binding]; other site
680646003997	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501
680646003998	putative Iron-sulfur protein interface [polypeptide binding]; other site
680646003999	putative proximal heme binding site [chemical binding]; other site
680646004000	putative SdhD-like interface [polypeptide binding]; other site
680646004001	putative distal heme binding site [chemical binding]; other site
680646004002	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
680646004003	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
680646004004	Substrate binding site [chemical binding]; other site
680646004005	Cupin domain; Region: Cupin_2; cl09118
680646004006	hypothetical protein; Provisional; Region: PRK13679
680646004007	tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233
680646004008	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
680646004009	active site
680646004010	HIGH motif; other site
680646004011	dimer interface [polypeptide binding]; other site
680646004012	KMSKS motif; other site
680646004013	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
680646004014	putative active site [active]
680646004015	putative DNA binding site [nucleotide binding]; other site
680646004016	putative phosphate binding site [ion binding]; other site
680646004017	putative catalytic site [active]
680646004018	metal binding site A [ion binding]; metal-binding site
680646004019	putative AP binding site [nucleotide binding]; other site
680646004020	putative metal binding site B [ion binding]; other site
680646004021	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
680646004022	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
680646004023	DNA-binding site [nucleotide binding]; DNA binding site
680646004024	UTRA domain; Region: UTRA; cl06649
680646004025	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
680646004026	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
680646004027	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
680646004028	homodimer interface [polypeptide binding]; other site
680646004029	NADP binding site [chemical binding]; other site
680646004030	substrate binding site [chemical binding]; other site
680646004031	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378
680646004032	dimer interface [polypeptide binding]; other site
680646004033	glycine-pyridoxal phosphate binding site [chemical binding]; other site
680646004034	active site
680646004035	folate binding site [chemical binding]; other site
680646004036	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
680646004037	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
680646004038	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421
680646004039	purine monophosphate binding site [chemical binding]; other site
680646004040	dimer interface [polypeptide binding]; other site
680646004041	putative catalytic residues [active]
680646004042	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
680646004043	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
680646004044	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
680646004045	active site
680646004046	substrate binding site [chemical binding]; other site
680646004047	cosubstrate binding site; other site
680646004048	catalytic site [active]
680646004049	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
680646004050	putative active site [active]
680646004051	Uncharacterized conserved protein [Function unknown]; Region: COG4715
680646004052	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
680646004053	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
680646004054	ATP binding site [chemical binding]; other site
680646004055	putative Mg++ binding site [ion binding]; other site
680646004056	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
680646004057	nucleotide binding region [chemical binding]; other site
680646004058	ATP-binding site [chemical binding]; other site
680646004059	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
680646004060	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
680646004061	active site
680646004062	catalytic tetrad [active]
680646004063	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
680646004064	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
680646004065	Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525
680646004066	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685
680646004067	RNA binding site [nucleotide binding]; other site
680646004068	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
680646004069	Amino acid permease; Region: AA_permease; pfam00324
680646004070	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
680646004071	Amino acid permease; Region: AA_permease; pfam00324
680646004072	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
680646004073	S-adenosylmethionine binding site [chemical binding]; other site
680646004074	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
680646004075	DNA binding residues [nucleotide binding]
680646004076	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257
680646004077	HSP70 interaction site [polypeptide binding]; other site
680646004078	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
680646004079	DnaJ C terminal domain; Region: DnaJ_C; pfam01556
680646004080	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446
680646004081	dimer interface [polypeptide binding]; other site
680646004082	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
680646004083	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
680646004084	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
680646004085	Low molecular weight phosphatase family; Region: LMWPc; cd00115
680646004086	Active site [active]
680646004087	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646004088	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
680646004089	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
680646004090	putative substrate translocation pore; other site
680646004091	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
680646004092	Aminotransferase class IV; Region: Aminotran_4; pfam01063
680646004093	pyridoxal 5'-phosphate binding site [chemical binding]; other site
680646004094	catalytic residue [active]
680646004095	Cobalt transport protein; Region: CbiQ; cl00463
680646004096	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
680646004097	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This...; Region: ABC_cobalt_CbiO_domain1; cd03225
680646004098	Walker A/P-loop; other site
680646004099	ATP binding site [chemical binding]; other site
680646004100	Q-loop/lid; other site
680646004101	ABC transporter signature motif; other site
680646004102	Walker B; other site
680646004103	D-loop; other site
680646004104	H-loop/switch region; other site
680646004105	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This...; Region: ABC_cobalt_CbiO_domain1; cd03225
680646004106	Walker A/P-loop; other site
680646004107	ATP binding site [chemical binding]; other site
680646004108	Q-loop/lid; other site
680646004109	ABC transporter signature motif; other site
680646004110	Walker B; other site
680646004111	D-loop; other site
680646004112	H-loop/switch region; other site
680646004113	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943
680646004114	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
680646004115	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
680646004116	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564
680646004117	thiamine phosphate binding site [chemical binding]; other site
680646004118	active site
680646004119	pyrophosphate binding site [ion binding]; other site
680646004120	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881
680646004121	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
680646004122	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
680646004123	thiS-thiF/thiG interaction site; other site
680646004124	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
680646004125	ThiS interaction site; other site
680646004126	putative active site [active]
680646004127	tetramer interface [polypeptide binding]; other site
680646004128	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757
680646004129	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
680646004130	ATP binding site [chemical binding]; other site
680646004131	substrate interface [chemical binding]; other site
680646004132	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
680646004133	Methylamine utilisation protein MauE; Region: MauE; pfam07291
680646004134	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227
680646004135	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
680646004136	S-adenosylmethionine binding site [chemical binding]; other site
680646004137	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
680646004138	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
680646004139	potential protein location (hypothetical protein) that overlaps protein (uncharacterized membrane protein)
680646004140	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
680646004141	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
680646004142	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591
680646004143	IHF dimer interface [polypeptide binding]; other site
680646004144	IHF - DNA interface [nucleotide binding]; other site
680646004145	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
680646004146	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
680646004147	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
680646004148	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
680646004149	active site
680646004150	catalytic triad [active]
680646004151	oxyanion hole [active]
680646004152	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
680646004153	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
680646004154	Walker A/P-loop; other site
680646004155	ATP binding site [chemical binding]; other site
680646004156	Q-loop/lid; other site
680646004157	ABC transporter signature motif; other site
680646004158	Walker B; other site
680646004159	D-loop; other site
680646004160	H-loop/switch region; other site
680646004161	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
680646004162	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
680646004163	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
680646004164	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
680646004165	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
680646004166	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
680646004167	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
680646004168	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
680646004169	active site
680646004170	HIGH motif; other site
680646004171	nucleotide binding site [chemical binding]; other site
680646004172	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
680646004173	KMSKS motif; other site
680646004174	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
680646004175	tRNA binding surface [nucleotide binding]; other site
680646004176	anticodon binding site; other site
680646004177	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554
680646004178	homotrimer interaction site [polypeptide binding]; other site
680646004179	zinc binding site [ion binding]; other site
680646004180	CDP-binding sites; other site
680646004181	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
680646004182	substrate binding site [chemical binding]; other site
680646004183	dimer interface [polypeptide binding]; other site
680646004184	potential protein location (hypothetical protein) that overlaps protein (response regulator consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain)
680646004185	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
680646004186	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
680646004187	active site
680646004188	phosphorylation site [posttranslational modification]
680646004189	intermolecular recognition site; other site
680646004190	dimerization interface [polypeptide binding]; other site
680646004191	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
680646004192	DNA binding site [nucleotide binding]
680646004193	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
680646004194	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
680646004195	dimer interface [polypeptide binding]; other site
680646004196	phosphorylation site [posttranslational modification]
680646004197	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
680646004198	ATP binding site [chemical binding]; other site
680646004199	Mg2+ binding site [ion binding]; other site
680646004200	G-X-G motif; other site
680646004201	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
680646004202	catalytic core [active]
680646004203	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
680646004204	Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
680646004205	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
680646004206	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
680646004207	homodimer interface [polypeptide binding]; other site
680646004208	substrate-cofactor binding pocket; other site
680646004209	pyridoxal 5'-phosphate binding site [chemical binding]; other site
680646004210	catalytic residue [active]
680646004211	thymidylate kinase; Validated; Region: tmk; PRK00698
680646004212	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672
680646004213	TMP-binding site; other site
680646004214	ATP-binding site [chemical binding]; other site
680646004215	DNA polymerase III subunit delta'; Validated; Region: PRK07940
680646004216	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646004217	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
680646004218	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
680646004219	mannose-6-phosphate isomerase; Provisional; Region: PRK15131; cl14659
680646004220	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
680646004221	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
680646004222	active site
680646004223	substrate binding site [chemical binding]; other site
680646004224	metal binding site [ion binding]; metal-binding site
680646004225	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
680646004226	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
680646004227	heme-binding site [chemical binding]; other site
680646004228	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
680646004229	FAD binding pocket [chemical binding]; other site
680646004230	FAD binding motif [chemical binding]; other site
680646004231	phosphate binding motif [ion binding]; other site
680646004232	beta-alpha-beta structure motif; other site
680646004233	NAD binding pocket [chemical binding]; other site
680646004234	Heme binding  pocket [chemical binding]; other site
680646004235	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
680646004236	Rrf2 family protein; Region: rrf2_super; TIGR00738
680646004237	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
680646004238	Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821
680646004239	active site
680646004240	substrate-binding site [chemical binding]; other site
680646004241	metal-binding site [ion binding]
680646004242	GTP binding site [chemical binding]; other site
680646004243	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
680646004244	potential protein location (hypothetical protein) that overlaps protein (ABC-type antimicrobial peptide transport system, permease component)
680646004245	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
680646004246	putative FMN binding site [chemical binding]; other site
680646004247	DEAD-like helicases superfamily; Region: DEXDc; smart00487
680646004248	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
680646004249	ATP binding site [chemical binding]; other site
680646004250	putative Mg++ binding site [ion binding]; other site
680646004251	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
680646004252	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
680646004253	nucleotide binding region [chemical binding]; other site
680646004254	ATP-binding site [chemical binding]; other site
680646004255	DEAD/H associated; Region: DEAD_assoc; pfam08494
680646004256	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
680646004257	HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008
680646004258	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
680646004259	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
680646004260	PseudoU_synth:  Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families.  This group consists of...; Region: PseudoU_synth; cl00130
680646004261	active site
680646004262	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996
680646004263	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
680646004264	Queuine tRNA-ribosyltransferase; Region: TGT; cl00409
680646004265	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
680646004266	hydrophobic ligand binding site; other site
680646004267	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
680646004268	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
680646004269	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586
680646004270	active site
680646004271	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
680646004272	ethanolamine permease; Region: 2A0305; TIGR00908
680646004273	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
680646004274	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756
680646004275	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
680646004276	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
680646004277	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270
680646004278	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
680646004279	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
680646004280	Walker A motif; other site
680646004281	ATP binding site [chemical binding]; other site
680646004282	Walker B motif; other site
680646004283	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
680646004284	recombination protein RecR; Reviewed; Region: recR; PRK00076
680646004285	RecR protein; Region: RecR; pfam02132
680646004286	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
680646004287	putative active site [active]
680646004288	putative metal-binding site [ion binding]; other site
680646004289	tetramer interface [polypeptide binding]; other site
680646004290	aspartate kinase; Reviewed; Region: PRK06635
680646004291	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
680646004292	putative nucleotide binding site [chemical binding]; other site
680646004293	putative catalytic residues [active]
680646004294	putative Mg ion binding site [ion binding]; other site
680646004295	putative aspartate binding site [chemical binding]; other site
680646004296	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
680646004297	putative allosteric regulatory site; other site
680646004298	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
680646004299	putative allosteric regulatory residue; other site
680646004300	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789
680646004301	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
680646004302	putative active site [active]
680646004303	catalytic triad [active]
680646004304	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
680646004305	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203
680646004306	dimerization interface [polypeptide binding]; other site
680646004307	ATP binding site [chemical binding]; other site
680646004308	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204
680646004309	dimerization interface [polypeptide binding]; other site
680646004310	ATP binding site [chemical binding]; other site
680646004311	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
680646004312	heme binding pocket [chemical binding]; other site
680646004313	heme ligand [chemical binding]; other site
680646004314	Htaa; Region: HtaA; pfam04213
680646004315	Htaa; Region: HtaA; pfam04213
680646004316	Htaa; Region: HtaA; pfam04213
680646004317	ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558
680646004318	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262
680646004319	intersubunit interface [polypeptide binding]; other site
680646004320	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
680646004321	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
680646004322	ABC-ATPase subunit  interface; other site
680646004323	dimer interface [polypeptide binding]; other site
680646004324	putative PBP binding regions; other site
680646004325	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
680646004326	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
680646004327	Walker A/P-loop; other site
680646004328	ATP binding site [chemical binding]; other site
680646004329	Q-loop/lid; other site
680646004330	ABC transporter signature motif; other site
680646004331	Walker B; other site
680646004332	D-loop; other site
680646004333	H-loop/switch region; other site
680646004334	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
680646004335	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
680646004336	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
680646004337	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
680646004338	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212
680646004339	active site turn [active]
680646004340	phosphorylation site [posttranslational modification]
680646004341	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
680646004342	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162
680646004343	HPr interaction site; other site
680646004344	glycerol kinase (GK) interaction site [polypeptide binding]; other site
680646004345	active site
680646004346	phosphorylation site [posttranslational modification]
680646004347	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
680646004348	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
680646004349	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
680646004350	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
680646004351	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
680646004352	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
680646004353	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
680646004354	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
680646004355	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
680646004356	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
680646004357	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
680646004358	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
680646004359	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
680646004360	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
680646004361	Walker A/P-loop; other site
680646004362	ATP binding site [chemical binding]; other site
680646004363	Q-loop/lid; other site
680646004364	ABC transporter signature motif; other site
680646004365	Walker B; other site
680646004366	D-loop; other site
680646004367	H-loop/switch region; other site
680646004368	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
680646004369	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
680646004370	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
680646004371	Walker A/P-loop; other site
680646004372	ATP binding site [chemical binding]; other site
680646004373	Q-loop/lid; other site
680646004374	ABC transporter signature motif; other site
680646004375	Walker B; other site
680646004376	D-loop; other site
680646004377	H-loop/switch region; other site
680646004378	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
680646004379	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
680646004380	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
680646004381	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
680646004382	dimer interface [polypeptide binding]; other site
680646004383	conserved gate region; other site
680646004384	putative PBP binding loops; other site
680646004385	ABC-ATPase subunit interface; other site
680646004386	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
680646004387	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
680646004388	dimer interface [polypeptide binding]; other site
680646004389	conserved gate region; other site
680646004390	putative PBP binding loops; other site
680646004391	ABC-ATPase subunit interface; other site
680646004392	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
680646004393	Major Facilitator Superfamily; Region: MFS_1; pfam07690
680646004394	putative substrate translocation pore; other site
680646004395	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
680646004396	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
680646004397	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
680646004398	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
680646004399	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
680646004400	putative active site [active]
680646004401	catalytic site [active]
680646004402	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
680646004403	putative active site [active]
680646004404	catalytic site [active]
680646004405	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
680646004406	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
680646004407	putative active site [active]
680646004408	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
680646004409	Dehydratase family; Region: ILVD_EDD; cl00340
680646004410	dihydroxy-acid dehydratase; Region: ilvD; TIGR00110
680646004411	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
680646004412	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
680646004413	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
680646004414	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
680646004415	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
680646004416	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
680646004417	dimer interface [polypeptide binding]; other site
680646004418	conserved gate region; other site
680646004419	putative PBP binding loops; other site
680646004420	ABC-ATPase subunit interface; other site
680646004421	OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment.  ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family...; Region: ABC_OpuCA_Osmoprotection; cd03295
680646004422	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
680646004423	Walker A/P-loop; other site
680646004424	ATP binding site [chemical binding]; other site
680646004425	Q-loop/lid; other site
680646004426	ABC transporter signature motif; other site
680646004427	Walker B; other site
680646004428	D-loop; other site
680646004429	H-loop/switch region; other site
680646004430	light-independent protochlorophyllide reductase, B subunit; Region: DPOR_BchB; TIGR01278
680646004431	ferredoxin-NADP+ reductase; Region: PLN02852
680646004432	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
680646004433	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424
680646004434	potential protein location (hypothetical protein) that overlaps protein (permease)
680646004435	Sulfate transporter family; Region: Sulfate_transp; cl00967
680646004436	Permease family; Region: Xan_ur_permease; pfam00860
680646004437	Sulfate transporter family; Region: Sulfate_transp; cl00967
680646004438	Permease family; Region: Xan_ur_permease; pfam00860
680646004439	SEC-C motif; Region: SEC-C; cl12132
680646004440	hypothetical protein; Provisional; Region: PRK04233
680646004441	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
680646004442	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
680646004443	active site
680646004444	non-prolyl cis peptide bond; other site
680646004445	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
680646004446	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293
680646004447	Walker A/P-loop; other site
680646004448	ATP binding site [chemical binding]; other site
680646004449	Q-loop/lid; other site
680646004450	ABC transporter signature motif; other site
680646004451	Walker B; other site
680646004452	D-loop; other site
680646004453	H-loop/switch region; other site
680646004454	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
680646004455	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
680646004456	substrate binding pocket [chemical binding]; other site
680646004457	membrane-bound complex binding site; other site
680646004458	potential protein location (hypothetical protein) that overlaps protein (ABC-type nitrate/sulfonate/bicarbonate transport system, permease component)
680646004459	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
680646004460	dimer interface [polypeptide binding]; other site
680646004461	conserved gate region; other site
680646004462	putative PBP binding loops; other site
680646004463	ABC-ATPase subunit interface; other site
680646004464	acetyl-CoA synthetase; Provisional; Region: PRK00174
680646004465	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
680646004466	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
680646004467	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064
680646004468	active site
680646004469	potential protein location (hypothetical protein) that overlaps protein (exonuclease III)
680646004470	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
680646004471	NAD(P) binding site [chemical binding]; other site
680646004472	putative active site [active]
680646004473	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
680646004474	putative substrate translocation pore; other site
680646004475	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
680646004476	Acylphosphatase; Region: Acylphosphatase; cl00551
680646004477	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
680646004478	potential protein location (hypothetical protein) that overlaps protein (uncharacterized conserved protein)
680646004479	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
680646004480	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015
680646004481	dimer interface [polypeptide binding]; other site
680646004482	decamer (pentamer of dimers) interface [polypeptide binding]; other site
680646004483	catalytic triad [active]
680646004484	peroxidatic and resolving cysteines [active]
680646004485	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
680646004486	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
680646004487	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
680646004488	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
680646004489	putative substrate translocation pore; other site
680646004490	UPF0126 domain; Region: UPF0126; pfam03458
680646004491	UPF0126 domain; Region: UPF0126; pfam03458
680646004492	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
680646004493	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262
680646004494	Walker A/P-loop; other site
680646004495	ATP binding site [chemical binding]; other site
680646004496	Q-loop/lid; other site
680646004497	ABC transporter signature motif; other site
680646004498	Walker B; other site
680646004499	D-loop; other site
680646004500	H-loop/switch region; other site
680646004501	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
680646004502	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
680646004503	dimer interface [polypeptide binding]; other site
680646004504	conserved gate region; other site
680646004505	putative PBP binding loops; other site
680646004506	ABC-ATPase subunit interface; other site
680646004507	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
680646004508	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
680646004509	substrate binding pocket [chemical binding]; other site
680646004510	membrane-bound complex binding site; other site
680646004511	hinge residues; other site
680646004512	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
680646004513	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
680646004514	substrate binding pocket [chemical binding]; other site
680646004515	membrane-bound complex binding site; other site
680646004516	hinge residues; other site
680646004517	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
680646004518	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
680646004519	homodimer interface [polypeptide binding]; other site
680646004520	substrate-cofactor binding pocket; other site
680646004521	pyridoxal 5'-phosphate binding site [chemical binding]; other site
680646004522	catalytic residue [active]
680646004523	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
680646004524	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
680646004525	homodimer interface [polypeptide binding]; other site
680646004526	substrate-cofactor binding pocket; other site
680646004527	pyridoxal 5'-phosphate binding site [chemical binding]; other site
680646004528	catalytic residue [active]
680646004529	Abi-like protein; Region: Abi_2; cl01988
680646004530	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
680646004531	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
680646004532	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
680646004533	homodimer interface [polypeptide binding]; other site
680646004534	substrate-cofactor binding pocket; other site
680646004535	pyridoxal 5'-phosphate binding site [chemical binding]; other site
680646004536	catalytic residue [active]
680646004537	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
680646004538	Domain of unknown function (DUF1963); Region: DUF1963; cl01600
680646004539	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor...; Region: FhuD; cd01146
680646004540	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
680646004541	siderophore binding site; other site
680646004542	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
680646004543	ABC-ATPase subunit  interface; other site
680646004544	dimer interface [polypeptide binding]; other site
680646004545	putative PBP binding regions; other site
680646004546	ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism]; Region: CeuC; COG4605
680646004547	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
680646004548	ABC-ATPase subunit  interface; other site
680646004549	dimer interface [polypeptide binding]; other site
680646004550	putative PBP binding regions; other site
680646004551	potential protein location (hypothetical protein) that overlaps protein (integrase)
680646004552	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
680646004553	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
680646004554	adenylosuccinate synthetase; Provisional; Region: PRK01117
680646004555	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108
680646004556	GDP-binding site [chemical binding]; other site
680646004557	ACT binding site; other site
680646004558	IMP binding site; other site
680646004559	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
680646004560	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
680646004561	active site
680646004562	catalytic residues [active]
680646004563	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain...; Region: PA; cl08238
680646004564	PA/protease or protease-like domain interface [polypeptide binding]; other site
680646004565	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
680646004566	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
680646004567	S-layer homology domain; Region: SLH; pfam00395
680646004568	S-layer homology domain; Region: SLH; pfam00395
680646004569	S-layer homology domain; Region: SLH; pfam00395
680646004570	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
680646004571	putative active site [active]
680646004572	catalytic triad [active]
680646004573	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
680646004574	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
680646004575	S-layer homology domain; Region: SLH; pfam00395
680646004576	S-layer homology domain; Region: SLH; pfam00395
680646004577	S-layer homology domain; Region: SLH; pfam00395
680646004578	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
680646004579	putative active site [active]
680646004580	catalytic triad [active]
680646004581	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain...; Region: PA; cl08238
680646004582	PA/protease or protease-like domain interface [polypeptide binding]; other site
680646004583	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
680646004584	catalytic residues [active]
680646004585	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
680646004586	S-layer homology domain; Region: SLH; pfam00395
680646004587	S-layer homology domain; Region: SLH; pfam00395
680646004588	S-layer homology domain; Region: SLH; pfam00395
680646004589	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
680646004590	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553
680646004591	homodimer interface [polypeptide binding]; other site
680646004592	NAD binding pocket [chemical binding]; other site
680646004593	ATP binding pocket [chemical binding]; other site
680646004594	Mg binding site [ion binding]; other site
680646004595	active-site loop [active]
680646004596	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
680646004597	MatE; Region: MatE; pfam01554
680646004598	MatE; Region: MatE; pfam01554
680646004599	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
680646004600	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
680646004601	pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180
680646004602	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
680646004603	active site
680646004604	multimer interface [polypeptide binding]; other site
680646004605	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
680646004606	predicted active site [active]
680646004607	catalytic triad [active]
680646004608	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
680646004609	active site
680646004610	metal binding site [ion binding]; metal-binding site
680646004611	CAAX amino terminal protease self- immunity; Region: Abi; cl00558
680646004612	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
680646004613	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
680646004614	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
680646004615	Multicopper oxidase; Region: Cu-oxidase; cl14658
680646004616	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
680646004617	N-acetyl-D-glucosamine binding site [chemical binding]; other site
680646004618	catalytic residue [active]
680646004619	Cytochrome P450; Region: p450; cl12078
680646004620	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
680646004621	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
680646004622	putative substrate translocation pore; other site
680646004623	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
680646004624	potential protein location (hypothetical protein) that overlaps protein (predicted oxidoreductase)
680646004625	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
680646004626	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
680646004627	active site
680646004628	catalytic tetrad [active]
680646004629	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
680646004630	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646004631	Walker A/P-loop; other site
680646004632	ATP binding site [chemical binding]; other site
680646004633	Q-loop/lid; other site
680646004634	ABC transporter signature motif; other site
680646004635	Walker B; other site
680646004636	D-loop; other site
680646004637	H-loop/switch region; other site
680646004638	Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219
680646004639	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537
680646004640	FAD binding site [chemical binding]; other site
680646004641	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
680646004642	N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_N_terminal_like; cd03312
680646004643	THF binding site; other site
680646004644	C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311
680646004645	substrate binding site [chemical binding]; other site
680646004646	THF binding site; other site
680646004647	zinc-binding site [ion binding]; other site
680646004648	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
680646004649	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
680646004650	putative substrate translocation pore; other site
680646004651	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
680646004652	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
680646004653	active site
680646004654	Zn binding site [ion binding]; other site
680646004655	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cd01391
680646004656	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
680646004657	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
680646004658	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646004659	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646004660	Protein kinase domain; Region: Pkinase; pfam00069
680646004661	Catalytic domain of Protein Kinases; Region: PKc; cd00180
680646004662	active site
680646004663	ATP binding site [chemical binding]; other site
680646004664	substrate binding site [chemical binding]; other site
680646004665	activation loop (A-loop); other site
680646004666	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
680646004667	RHS Repeat; Region: RHS_repeat; cl11982
680646004668	RHS Repeat; Region: RHS_repeat; cl11982
680646004669	RHS Repeat; Region: RHS_repeat; cl11982
680646004670	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
680646004671	putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773
680646004672	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
680646004673	putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773
680646004674	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
680646004675	putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773
680646004676	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
680646004677	putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773
680646004678	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
680646004679	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262
680646004680	anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772
680646004681	intersubunit interface [polypeptide binding]; other site
680646004682	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
680646004683	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262
680646004684	putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773
680646004685	actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769
680646004686	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
680646004687	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235
680646004688	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
680646004689	ABC-ATPase subunit  interface; other site
680646004690	dimer interface [polypeptide binding]; other site
680646004691	putative PBP binding regions; other site
680646004692	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286
680646004693	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
680646004694	catalytic Zn binding site [ion binding]; other site
680646004695	structural Zn binding site [ion binding]; other site
680646004696	NAD(P) binding site [chemical binding]; other site
680646004697	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
680646004698	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
680646004699	putative substrate translocation pore; other site
680646004700	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
680646004701	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
680646004702	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447
680646004703	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447
680646004704	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
680646004705	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646004706	Walker A/P-loop; other site
680646004707	ATP binding site [chemical binding]; other site
680646004708	Q-loop/lid; other site
680646004709	ABC transporter signature motif; other site
680646004710	Walker B; other site
680646004711	D-loop; other site
680646004712	H-loop/switch region; other site
680646004713	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
680646004714	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
680646004715	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
680646004716	Walker A/P-loop; other site
680646004717	ATP binding site [chemical binding]; other site
680646004718	Q-loop/lid; other site
680646004719	ABC transporter signature motif; other site
680646004720	Walker B; other site
680646004721	D-loop; other site
680646004722	H-loop/switch region; other site
680646004723	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
680646004724	Divergent AAA domain; Region: AAA_4; pfam04326
680646004725	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
680646004726	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
680646004727	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
680646004728	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
680646004729	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
680646004730	Transcriptional regulators [Transcription]; Region: MarR; COG1846
680646004731	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
680646004732	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
680646004733	Ferritin-like domain; Region: Ferritin; pfam00210
680646004734	ferroxidase diiron center [ion binding]; other site
680646004735	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
680646004736	lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983
680646004737	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
680646004738	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322
680646004739	dimer interface [polypeptide binding]; other site
680646004740	putative anticodon binding site; other site
680646004741	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
680646004742	motif 1; other site
680646004743	dimer interface [polypeptide binding]; other site
680646004744	active site
680646004745	motif 2; other site
680646004746	motif 3; other site
680646004747	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
680646004748	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
680646004749	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
680646004750	phosphopeptide binding site; other site
680646004751	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
680646004752	phosphopeptide binding site; other site
680646004753	Protein phosphatase 2C; Region: PP2C; pfam00481
680646004754	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
680646004755	Active site [active]
680646004756	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
680646004757	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
680646004758	Catalytic domain of Protein Kinases; Region: PKc; cd00180
680646004759	active site
680646004760	ATP binding site [chemical binding]; other site
680646004761	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
680646004762	substrate binding site [chemical binding]; other site
680646004763	activation loop (A-loop); other site
680646004764	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577
680646004765	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577
680646004766	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
680646004767	active site
680646004768	ATP binding site [chemical binding]; other site
680646004769	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
680646004770	substrate binding site [chemical binding]; other site
680646004771	activation loop (A-loop); other site
680646004772	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577
680646004773	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577
680646004774	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577
680646004775	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
680646004776	Glutamine amidotransferase class-I; Region: GATase; pfam00117
680646004777	glutamine binding [chemical binding]; other site
680646004778	catalytic triad [active]
680646004779	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase_D_5; cd05830
680646004780	active site
680646004781	catalytic site [active]
680646004782	Uncharacterised protein family (UPF0233); Region: UPF0233; cl11506
680646004783	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
680646004784	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
680646004785	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
680646004786	dimerization interface [polypeptide binding]; other site
680646004787	LysE type translocator; Region: LysE; cl00565
680646004788	potential protein location (hypothetical protein) that overlaps protein (D-mannonate dehydratase)
680646004789	replicative DNA helicase; Region: DnaB; TIGR00665
680646004790	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
680646004791	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
680646004792	Walker A motif; other site
680646004793	ATP binding site [chemical binding]; other site
680646004794	Walker B motif; other site
680646004795	DNA binding loops [nucleotide binding]
680646004796	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
680646004797	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
680646004798	homodimer interface [polypeptide binding]; other site
680646004799	active site
680646004800	TDP-binding site; other site
680646004801	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
680646004802	S-adenosylmethionine binding site [chemical binding]; other site
680646004803	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
680646004804	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
680646004805	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
680646004806	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
680646004807	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
680646004808	dimer interface [polypeptide binding]; other site
680646004809	ssDNA binding site [nucleotide binding]; other site
680646004810	tetramer (dimer of dimers) interface [polypeptide binding]; other site
680646004811	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
680646004812	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
680646004813	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
680646004814	active site
680646004815	NTP binding site [chemical binding]; other site
680646004816	metal binding triad [ion binding]; metal-binding site
680646004817	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
680646004818	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
680646004819	Zn2+ binding site [ion binding]; other site
680646004820	Mg2+ binding site [ion binding]; other site
680646004821	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
680646004822	active site
680646004823	Ap6A binding site [chemical binding]; other site
680646004824	nudix motif; other site
680646004825	metal binding site [ion binding]; metal-binding site
680646004826	integral membrane protein MviN; Region: mviN; TIGR01695
680646004827	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
680646004828	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520
680646004829	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
680646004830	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
680646004831	catalytic residues [active]
680646004832	ParB-like partition proteins; Region: parB_part; TIGR00180
680646004833	ParB-like nuclease domain; Region: ParBc; cl02129
680646004834	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
680646004835	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
680646004836	P-loop; other site
680646004837	Magnesium ion binding site [ion binding]; other site
680646004838	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
680646004839	Magnesium ion binding site [ion binding]; other site
680646004840	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
680646004841	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
680646004842	potential protein location (hypothetical protein) that overlaps protein (predicted RNA-binding protein)
680646004843	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
680646004844	G-X-X-G motif; other site
680646004845	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
680646004846	RxxxH motif; other site
680646004847	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
680646004848	Domain of unknown function DUF37; Region: DUF37; cl00506
680646004849	Ribonuclease P; Region: Ribonuclease_P; cl00457
680646004850	Ribosomal protein L34; Region: Ribosomal_L34; cl00370