-- dump date 20111121_014431 -- class Genbank::misc_feature -- table misc_feature_note -- id note 471857000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 471857000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471857000003 Walker A motif; other site 471857000004 ATP binding site [chemical binding]; other site 471857000005 Walker B motif; other site 471857000006 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 471857000007 DnaA box-binding interface [nucleotide binding]; other site 471857000008 DNA polymerase III subunit beta; Validated; Region: PRK07761 471857000009 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 471857000010 putative DNA binding surface [nucleotide binding]; other site 471857000011 dimer interface [polypeptide binding]; other site 471857000012 beta-clamp/clamp loader binding surface; other site 471857000013 beta-clamp/translesion DNA polymerase binding surface; other site 471857000014 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857000015 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 471857000016 recombination protein F; Reviewed; Region: recF; PRK00064 471857000017 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 471857000018 Walker A/P-loop; other site 471857000019 ATP binding site [chemical binding]; other site 471857000020 Q-loop/lid; other site 471857000021 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857000022 ABC transporter signature motif; other site 471857000023 Walker B; other site 471857000024 D-loop; other site 471857000025 H-loop/switch region; other site 471857000026 Protein of unknown function (DUF721); Region: DUF721; cl02324 471857000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 471857000028 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 471857000029 anchoring element; other site 471857000030 dimer interface [polypeptide binding]; other site 471857000031 ATP binding site [chemical binding]; other site 471857000032 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 471857000033 active site 471857000034 putative metal-binding site [ion binding]; other site 471857000035 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 471857000036 DNA gyrase subunit A; Validated; Region: PRK05560 471857000037 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 471857000038 CAP-like domain; other site 471857000039 Active site [active] 471857000040 primary dimer interface [polypeptide binding]; other site 471857000041 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471857000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471857000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471857000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471857000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471857000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471857000047 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 471857000048 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 471857000049 active site 471857000050 NTP binding site [chemical binding]; other site 471857000051 metal binding triad [ion binding]; metal-binding site 471857000052 antibiotic binding site [chemical binding]; other site 471857000053 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 471857000054 nudix motif; other site 471857000055 Predicted membrane protein [Function unknown]; Region: COG2311 471857000056 Protein of unknown function (DUF418); Region: DUF418; cl12135 471857000057 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857000058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471857000059 active site 471857000060 phosphorylation site [posttranslational modification] 471857000061 intermolecular recognition site; other site 471857000062 dimerization interface [polypeptide binding]; other site 471857000063 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471857000064 DNA binding residues [nucleotide binding] 471857000065 dimerization interface [polypeptide binding]; other site 471857000066 Histidine kinase; Region: HisKA_3; pfam07730 471857000067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471857000068 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 471857000069 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 471857000070 active site 471857000071 Rhomboid family; Region: Rhomboid; cl11446 471857000072 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 471857000073 Uncharacterised protein family (UPF0233); Region: UPF0233; cl11506 471857000074 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase_D_5; cd05830 471857000075 active site 471857000076 catalytic site [active] 471857000077 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857000078 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857000079 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 471857000080 Walker A/P-loop; other site 471857000081 ATP binding site [chemical binding]; other site 471857000082 Q-loop/lid; other site 471857000083 ABC transporter signature motif; other site 471857000084 Walker B; other site 471857000085 D-loop; other site 471857000086 H-loop/switch region; other site 471857000087 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471857000088 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 471857000089 Glutamine amidotransferase class-I; Region: GATase; pfam00117 471857000090 glutamine binding [chemical binding]; other site 471857000091 catalytic triad [active] 471857000092 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471857000093 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471857000094 active site 471857000095 ATP binding site [chemical binding]; other site 471857000096 substrate binding site [chemical binding]; other site 471857000097 activation loop (A-loop); other site 471857000098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 471857000099 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 471857000100 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 471857000101 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 471857000102 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 471857000103 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471857000104 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471857000105 active site 471857000106 ATP binding site [chemical binding]; other site 471857000107 substrate binding site [chemical binding]; other site 471857000108 activation loop (A-loop); other site 471857000109 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 471857000110 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 471857000111 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 471857000112 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 471857000113 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 471857000114 Active site [active] 471857000115 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471857000116 phosphopeptide binding site; other site 471857000117 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 471857000118 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471857000119 phosphopeptide binding site; other site 471857000120 TQXA domain; Region: TQXA_dom; TIGR03934 471857000121 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 471857000122 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857000123 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471857000124 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 471857000125 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857000126 NAD(P) binding site [chemical binding]; other site 471857000127 active site 471857000128 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 471857000129 FAD binding domain; Region: FAD_binding_4; pfam01565 471857000130 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 471857000131 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 471857000132 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 471857000133 dimer interface [polypeptide binding]; other site 471857000134 active site 471857000135 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471857000136 substrate binding site [chemical binding]; other site 471857000137 catalytic residue [active] 471857000138 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857000139 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857000140 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471857000141 Phosphotransferase enzyme family; Region: APH; pfam01636 471857000142 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 471857000143 Copper resistance protein D; Region: CopD; cl00563 471857000144 BCCT family transporter; Region: BCCT; cl00569 471857000145 Copper resistance protein CopC; Region: CopC; cl01012 471857000146 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 471857000147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 471857000148 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 471857000149 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family...; Region: ABC_OpuCA_Osmoprotection; cd03295 471857000150 Walker A/P-loop; other site 471857000151 ATP binding site [chemical binding]; other site 471857000152 Q-loop/lid; other site 471857000153 ABC transporter signature motif; other site 471857000154 Walker B; other site 471857000155 D-loop; other site 471857000156 H-loop/switch region; other site 471857000157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857000158 dimer interface [polypeptide binding]; other site 471857000159 conserved gate region; other site 471857000160 putative PBP binding loops; other site 471857000161 ABC-ATPase subunit interface; other site 471857000162 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 471857000163 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 471857000164 TM0106 family; Region: TIGR03491 471857000165 sorbitol dehydrogenase; Provisional; Region: PRK07067 471857000166 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857000167 NAD(P) binding site [chemical binding]; other site 471857000168 active site 471857000169 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 471857000170 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 471857000171 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 471857000172 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 471857000173 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 471857000174 NADP-binding site; other site 471857000175 homotetramer interface [polypeptide binding]; other site 471857000176 substrate binding site [chemical binding]; other site 471857000177 homodimer interface [polypeptide binding]; other site 471857000178 active site 471857000179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471857000180 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471857000181 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471857000182 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471857000183 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471857000184 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 471857000185 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471857000186 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857000187 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 471857000188 Histidine kinase; Region: His_kinase; pfam06580 471857000189 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857000190 ATP binding site [chemical binding]; other site 471857000191 Mg2+ binding site [ion binding]; other site 471857000192 G-X-G motif; other site 471857000193 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 471857000194 tandem repeat interface [polypeptide binding]; other site 471857000195 oligomer interface [polypeptide binding]; other site 471857000196 active site residues [active] 471857000197 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471857000198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471857000199 active site 471857000200 phosphorylation site [posttranslational modification] 471857000201 intermolecular recognition site; other site 471857000202 dimerization interface [polypeptide binding]; other site 471857000203 LytTr DNA-binding domain; Region: LytTR; cl04498 471857000204 Sodium:solute symporter family; Region: SSF; cl00456 471857000205 Sodium:solute symporter family; Region: SSF; cl00456 471857000206 Sodium:solute symporter family; Region: SSF; cl00456 471857000207 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471857000208 active site residue [active] 471857000209 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 471857000210 Protein of unknown function (DUF952); Region: DUF952; cl01393 471857000211 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 471857000212 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857000213 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471857000214 DNA binding residues [nucleotide binding] 471857000215 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 471857000216 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 471857000217 Ferritin-like domain; Region: Ferritin; pfam00210 471857000218 ferroxidase diiron center [ion binding]; other site 471857000219 Amidinotransferase; Region: Amidinotransf; cl12043 471857000220 Arginine deiminase [Amino acid transport and metabolism]; Region: ArcA; COG2235 471857000221 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 471857000222 BCCT family transporter; Region: BCCT; cl00569 471857000223 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857000224 Predicted membrane protein [Function unknown]; Region: COG2119 471857000225 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 471857000226 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 471857000227 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 471857000228 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 471857000229 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 471857000230 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 471857000231 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 471857000232 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 471857000233 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857000234 Walker A/P-loop; other site 471857000235 ATP binding site [chemical binding]; other site 471857000236 Q-loop/lid; other site 471857000237 ABC transporter signature motif; other site 471857000238 Walker B; other site 471857000239 D-loop; other site 471857000240 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 471857000241 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857000242 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471857000243 Walker A/P-loop; other site 471857000244 ATP binding site [chemical binding]; other site 471857000245 Q-loop/lid; other site 471857000246 ABC transporter signature motif; other site 471857000247 Walker B; other site 471857000248 D-loop; other site 471857000249 H-loop/switch region; other site 471857000250 GAF domain; Region: GAF; cl00853 471857000251 Histidine kinase; Region: HisKA_3; pfam07730 471857000252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471857000253 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857000254 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471857000255 active site 471857000256 phosphorylation site [posttranslational modification] 471857000257 intermolecular recognition site; other site 471857000258 dimerization interface [polypeptide binding]; other site 471857000259 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471857000260 DNA binding residues [nucleotide binding] 471857000261 dimerization interface [polypeptide binding]; other site 471857000262 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 471857000263 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 471857000264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857000265 dimer interface [polypeptide binding]; other site 471857000266 conserved gate region; other site 471857000267 putative PBP binding loops; other site 471857000268 ABC-ATPase subunit interface; other site 471857000269 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 471857000270 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 471857000271 Walker A/P-loop; other site 471857000272 ATP binding site [chemical binding]; other site 471857000273 Q-loop/lid; other site 471857000274 ABC transporter signature motif; other site 471857000275 Walker B; other site 471857000276 D-loop; other site 471857000277 H-loop/switch region; other site 471857000278 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 471857000279 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 471857000280 Uncharacterized conserved protein [Function unknown]; Region: COG4715 471857000281 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 471857000282 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857000283 pantothenate kinase; Provisional; Region: PRK05439 471857000284 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 471857000285 ATP-binding site [chemical binding]; other site 471857000286 CoA-binding site [chemical binding]; other site 471857000287 Mg2+-binding site [ion binding]; other site 471857000288 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 471857000289 ADP-ribose binding site [chemical binding]; other site 471857000290 prephenate dehydratase; Provisional; Region: PRK11898 471857000291 Prephenate dehydratase; Region: PDT; pfam00800 471857000292 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 471857000293 putative L-Phe binding site [chemical binding]; other site 471857000294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857000295 putative substrate translocation pore; other site 471857000296 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 471857000297 Glutathionylspermidine synthase; Region: GSP_synth; cl00503 471857000298 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 471857000299 haloalkane dehalogenase; Provisional; Region: PRK00870 471857000300 seryl-tRNA synthetase; Provisional; Region: PRK05431 471857000301 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 471857000302 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 471857000303 dimer interface [polypeptide binding]; other site 471857000304 active site 471857000305 motif 1; other site 471857000306 motif 2; other site 471857000307 motif 3; other site 471857000308 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 471857000309 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 471857000310 active site 471857000311 motif I; other site 471857000312 motif II; other site 471857000313 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 471857000314 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471857000315 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 471857000316 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857000317 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857000318 UbiA prenyltransferase family; Region: UbiA; cl00337 471857000319 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 471857000320 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 471857000321 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 471857000322 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 471857000323 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857000324 NAD(P) binding site [chemical binding]; other site 471857000325 active site 471857000326 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471857000327 FAD binding domain; Region: FAD_binding_4; pfam01565 471857000328 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 471857000329 GtrA-like protein; Region: GtrA; cl00971 471857000330 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 471857000331 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471857000332 active site 471857000333 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471857000334 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471857000335 active site 471857000336 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 471857000337 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 471857000338 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 471857000339 Walker A/P-loop; other site 471857000340 ATP binding site [chemical binding]; other site 471857000341 Q-loop/lid; other site 471857000342 ABC transporter signature motif; other site 471857000343 Walker B; other site 471857000344 D-loop; other site 471857000345 H-loop/switch region; other site 471857000346 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471857000347 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 471857000348 pseudaminic acid synthase; Region: PseI; TIGR03586 471857000349 NeuB family; Region: NeuB; cl00496 471857000350 SAF domain; Region: SAF; cl00555 471857000351 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 471857000352 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 471857000353 inhibitor-cofactor binding pocket; inhibition site 471857000354 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857000355 catalytic residue [active] 471857000356 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 471857000357 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 471857000358 NAD(P) binding site [chemical binding]; other site 471857000359 homodimer interface [polypeptide binding]; other site 471857000360 substrate binding site [chemical binding]; other site 471857000361 active site 471857000362 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471857000363 active site 471857000364 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 471857000365 Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012 471857000366 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 471857000367 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 471857000368 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471857000369 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471857000370 catalytic residue [active] 471857000371 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 471857000372 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 471857000373 NAD(P) binding site [chemical binding]; other site 471857000374 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 471857000375 M28, and M42; Region: Zinc_peptidase_like; cl14876 471857000376 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain...; Region: PA; cl08238 471857000377 PA/protease or protease-like domain interface [polypeptide binding]; other site 471857000378 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 471857000379 active site 471857000380 metal binding site [ion binding]; metal-binding site 471857000381 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471857000382 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857000383 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 471857000384 Predicted transcriptional regulator [Transcription]; Region: COG1959 471857000385 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857000386 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471857000387 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857000388 NAD(P) binding site [chemical binding]; other site 471857000389 active site 471857000390 Domain of unknown function (DUF955); Region: DUF955; cl01076 471857000391 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471857000392 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 471857000393 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 471857000394 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 471857000395 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 471857000396 dimer interface [polypeptide binding]; other site 471857000397 active site 471857000398 CoA binding pocket [chemical binding]; other site 471857000399 cyclase homology domain; Region: CHD; cd07302 471857000400 nucleotidyl binding site; other site 471857000401 metal binding site [ion binding]; metal-binding site 471857000402 dimer interface [polypeptide binding]; other site 471857000403 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 471857000404 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 471857000405 putative DNA binding site [nucleotide binding]; other site 471857000406 putative homodimer interface [polypeptide binding]; other site 471857000407 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 471857000408 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 471857000409 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 471857000410 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857000411 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471857000412 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471857000413 DNA binding residues [nucleotide binding] 471857000414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471857000415 peptide chain release factor eRF/aRF, subunit 1; Region: eRF; TIGR00108 471857000416 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 471857000417 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 471857000418 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 471857000419 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471857000420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857000421 homodimer interface [polypeptide binding]; other site 471857000422 catalytic residue [active] 471857000423 Dienelactone hydrolase family; Region: DLH; pfam01738 471857000424 PPE family; Region: PPE; pfam00823 471857000425 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 471857000426 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 471857000427 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857000428 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 471857000429 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471857000430 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857000431 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 471857000432 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 471857000433 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 471857000434 inhibitor-cofactor binding pocket; inhibition site 471857000435 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857000436 catalytic residue [active] 471857000437 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 471857000438 nudix motif; other site 471857000439 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 471857000440 putative metal binding site [ion binding]; other site 471857000441 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471857000442 dimerization interface [polypeptide binding]; other site 471857000443 putative DNA binding site [nucleotide binding]; other site 471857000444 putative Zn2+ binding site [ion binding]; other site 471857000445 haloalkane dehalogenase; Provisional; Region: PRK03592 471857000446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471857000447 S-adenosylmethionine binding site [chemical binding]; other site 471857000448 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857000449 non-specific DNA binding site [nucleotide binding]; other site 471857000450 salt bridge; other site 471857000451 sequence-specific DNA binding site [nucleotide binding]; other site 471857000452 Cupin domain; Region: Cupin_2; cl09118 471857000453 Protein of unknown function (DUF421); Region: DUF421; cl00990 471857000454 Protein of unknown function DUF262; Region: DUF262; cl14890 471857000455 Uncharacterized conserved protein (DUF2081); Region: DUF2081; cl09179 471857000456 Divergent AAA domain; Region: AAA_4; pfam04326 471857000457 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 471857000458 asparagine synthetase B; Provisional; Region: asnB; PRK09431 471857000459 dimer interface [polypeptide binding]; other site 471857000460 active site 471857000461 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 471857000462 Ligand Binding Site [chemical binding]; other site 471857000463 Molecular Tunnel; other site 471857000464 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857000465 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471857000466 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 471857000467 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 471857000468 putative active site [active] 471857000469 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471857000470 DNA binding residues [nucleotide binding] 471857000471 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 471857000472 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 471857000473 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471857000474 S-adenosylmethionine binding site [chemical binding]; other site 471857000475 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857000476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471857000477 active site 471857000478 phosphorylation site [posttranslational modification] 471857000479 intermolecular recognition site; other site 471857000480 dimerization interface [polypeptide binding]; other site 471857000481 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471857000482 DNA binding residues [nucleotide binding] 471857000483 dimerization interface [polypeptide binding]; other site 471857000484 Histidine kinase; Region: HisKA_3; pfam07730 471857000485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471857000486 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471857000487 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 471857000488 Walker A/P-loop; other site 471857000489 ATP binding site [chemical binding]; other site 471857000490 Q-loop/lid; other site 471857000491 ABC transporter signature motif; other site 471857000492 Walker B; other site 471857000493 D-loop; other site 471857000494 H-loop/switch region; other site 471857000495 Nitrate and nitrite sensing; Region: NIT; pfam08376 471857000496 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471857000497 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471857000498 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 471857000499 Protein of unknown function (DUF742); Region: DUF742; pfam05331 471857000500 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471857000501 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 471857000502 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 471857000503 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471857000504 S-adenosylmethionine binding site [chemical binding]; other site 471857000505 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 471857000506 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 471857000507 Cysteine-rich domain; Region: CCG; pfam02754 471857000508 Cysteine-rich domain; Region: CCG; pfam02754 471857000509 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 471857000510 FAD binding domain; Region: FAD_binding_4; pfam01565 471857000511 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 471857000512 FAD binding domain; Region: FAD_binding_4; pfam01565 471857000513 Cytochrome P450; Region: p450; cl12078 471857000514 Predicted membrane protein [Function unknown]; Region: COG2364 471857000515 hypothetical protein; Provisional; Region: PRK08912 471857000516 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471857000517 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857000518 homodimer interface [polypeptide binding]; other site 471857000519 catalytic residue [active] 471857000520 Protein of unknown function (DUF445); Region: DUF445; pfam04286 471857000521 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857000522 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471857000523 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 471857000524 Walker A/P-loop; other site 471857000525 ATP binding site [chemical binding]; other site 471857000526 Q-loop/lid; other site 471857000527 ABC transporter signature motif; other site 471857000528 Walker B; other site 471857000529 D-loop; other site 471857000530 H-loop/switch region; other site 471857000531 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3809 471857000532 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857000533 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 471857000534 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857000535 non-specific DNA binding site [nucleotide binding]; other site 471857000536 salt bridge; other site 471857000537 sequence-specific DNA binding site [nucleotide binding]; other site 471857000538 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 471857000539 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-...; Region: PA2301; cd04939 471857000540 putative deacylase active site [active] 471857000541 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 471857000542 Prostaglandin dehydrogenases; Region: PGDH; cd05288 471857000543 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 471857000544 NAD(P) binding site [chemical binding]; other site 471857000545 substrate binding site [chemical binding]; other site 471857000546 dimer interface [polypeptide binding]; other site 471857000547 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 471857000548 active site 471857000549 substrate binding site [chemical binding]; other site 471857000550 cosubstrate binding site; other site 471857000551 catalytic site [active] 471857000552 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 471857000553 active site 471857000554 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 471857000555 MbtH-like protein; Region: MbtH; cl01279 471857000556 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 471857000557 ABC-ATPase subunit interface; other site 471857000558 dimer interface [polypeptide binding]; other site 471857000559 putative PBP binding regions; other site 471857000560 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 471857000561 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 471857000562 ABC-ATPase subunit interface; other site 471857000563 dimer interface [polypeptide binding]; other site 471857000564 putative PBP binding regions; other site 471857000565 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 471857000566 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 471857000567 Walker A/P-loop; other site 471857000568 ATP binding site [chemical binding]; other site 471857000569 Q-loop/lid; other site 471857000570 ABC transporter signature motif; other site 471857000571 Walker B; other site 471857000572 D-loop; other site 471857000573 H-loop/switch region; other site 471857000574 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 471857000575 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 471857000576 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 471857000577 putative active site [active] 471857000578 putative substrate binding site [chemical binding]; other site 471857000579 putative cosubstrate binding site; other site 471857000580 catalytic site [active] 471857000581 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 471857000582 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 471857000583 FAD binding domain; Region: FAD_binding_4; pfam01565 471857000584 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 471857000585 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857000586 NAD(P) binding site [chemical binding]; other site 471857000587 active site 471857000588 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471857000589 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 471857000590 UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449 471857000591 putative ADP-binding pocket [chemical binding]; other site 471857000592 Protein of unknown function (DUF2596); Region: DUF2596; pfam10770 471857000593 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 471857000594 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471857000595 catalytic core [active] 471857000596 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471857000597 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 471857000598 dimer interface [polypeptide binding]; other site 471857000599 phosphorylation site [posttranslational modification] 471857000600 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857000601 ATP binding site [chemical binding]; other site 471857000602 Mg2+ binding site [ion binding]; other site 471857000603 G-X-G motif; other site 471857000604 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471857000605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471857000606 active site 471857000607 phosphorylation site [posttranslational modification] 471857000608 intermolecular recognition site; other site 471857000609 dimerization interface [polypeptide binding]; other site 471857000610 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 471857000611 DNA binding site [nucleotide binding] 471857000612 exopolyphosphatase; Region: exo_poly_only; TIGR03706 471857000613 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 471857000614 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 471857000615 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471857000616 AP (apurinic/apyrimidinic) site pocket; other site 471857000617 DNA interaction; other site 471857000618 Metal-binding active site; metal-binding site 471857000619 Proline dehydrogenase; Region: Pro_dh; cl03282 471857000620 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 471857000621 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857000622 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471857000623 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857000624 NAD(P) binding site [chemical binding]; other site 471857000625 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471857000626 active site 471857000627 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 471857000628 putative acyl-acceptor binding pocket; other site 471857000629 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 471857000630 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 471857000631 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 471857000632 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857000633 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471857000634 DNA binding residues [nucleotide binding] 471857000635 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 471857000636 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857000637 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471857000638 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 471857000639 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 471857000640 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857000641 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 471857000642 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 471857000643 tRNA; other site 471857000644 putative tRNA binding site [nucleotide binding]; other site 471857000645 putative NADP binding site [chemical binding]; other site 471857000646 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 471857000647 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 471857000648 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 471857000649 domain interfaces; other site 471857000650 active site 471857000651 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 471857000652 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 471857000653 active site 471857000654 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 471857000655 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cl00338 471857000656 dimer interface [polypeptide binding]; other site 471857000657 active site 471857000658 Schiff base residues; other site 471857000659 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 471857000660 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 471857000661 inhibitor-cofactor binding pocket; inhibition site 471857000662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857000663 catalytic residue [active] 471857000664 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 471857000665 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 471857000666 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 471857000667 catalytic residues [active] 471857000668 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 471857000669 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 471857000670 ResB-like family; Region: ResB; pfam05140 471857000671 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 471857000672 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 471857000673 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 471857000674 DNA binding residues [nucleotide binding] 471857000675 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 471857000676 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 471857000677 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471857000678 catalytic residue [active] 471857000679 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; COG1575 471857000680 UbiA prenyltransferase family; Region: UbiA; cl00337 471857000681 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857000682 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857000683 non-specific DNA binding site [nucleotide binding]; other site 471857000684 salt bridge; other site 471857000685 sequence-specific DNA binding site [nucleotide binding]; other site 471857000686 naphthoate synthase; Validated; Region: PRK08321 471857000687 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471857000688 substrate binding site [chemical binding]; other site 471857000689 oxyanion hole (OAH) forming residues; other site 471857000690 trimer interface [polypeptide binding]; other site 471857000691 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 471857000692 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 471857000693 dimer interface [polypeptide binding]; other site 471857000694 tetramer interface [polypeptide binding]; other site 471857000695 PYR/PP interface [polypeptide binding]; other site 471857000696 TPP binding site [chemical binding]; other site 471857000697 TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key role in the menaquinone biosynthetic pathway, converting...; Region: TPP_SHCHC_synthase; cd02009 471857000698 TPP-binding site; other site 471857000699 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 471857000700 Zn binding site [ion binding]; other site 471857000701 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 471857000702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471857000703 S-adenosylmethionine binding site [chemical binding]; other site 471857000704 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857000705 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 471857000706 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 471857000707 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 471857000708 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 471857000709 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 471857000710 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 471857000711 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064 471857000712 putative dimer interface [polypeptide binding]; other site 471857000713 [2Fe-2S] cluster binding site [ion binding]; other site 471857000714 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 471857000715 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 471857000716 SLBB domain; Region: SLBB; pfam10531 471857000717 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 471857000718 NADH dehydrogenase subunit G; Validated; Region: PRK07860 471857000719 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471857000720 catalytic loop [active] 471857000721 iron binding site [ion binding]; other site 471857000722 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 471857000723 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 471857000724 molybdopterin cofactor binding site; other site 471857000725 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 471857000726 NADH dehydrogenase; Region: NADHdh; cl00469 471857000727 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 471857000728 4Fe-4S binding domain; Region: Fer4; cl02805 471857000729 4Fe-4S binding domain; Region: Fer4; cl02805 471857000730 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 471857000731 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 471857000732 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 471857000733 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 471857000734 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 471857000735 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 471857000736 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 471857000737 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 471857000738 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 471857000739 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 471857000740 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 471857000741 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 471857000742 substrate binding pocket [chemical binding]; other site 471857000743 chain length determination region; other site 471857000744 substrate-Mg2+ binding site; other site 471857000745 catalytic residues [active] 471857000746 aspartate-rich region 1; other site 471857000747 active site lid residues [active] 471857000748 aspartate-rich region 2; other site 471857000749 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 471857000750 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 471857000751 TPP-binding site [chemical binding]; other site 471857000752 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 471857000753 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 471857000754 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 471857000755 dimer interface [polypeptide binding]; other site 471857000756 PYR/PP interface [polypeptide binding]; other site 471857000757 TPP binding site [chemical binding]; other site 471857000758 substrate binding site [chemical binding]; other site 471857000759 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 471857000760 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857000761 Amidinotransferase; Region: Amidinotransf; cl12043 471857000762 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 471857000763 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 471857000764 ABC-ATPase subunit interface; other site 471857000765 dimer interface [polypeptide binding]; other site 471857000766 putative PBP binding regions; other site 471857000767 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 471857000768 ABC-ATPase subunit interface; other site 471857000769 dimer interface [polypeptide binding]; other site 471857000770 putative PBP binding regions; other site 471857000771 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 471857000772 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 471857000773 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 471857000774 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 471857000775 intersubunit interface [polypeptide binding]; other site 471857000776 Peptidase family M48; Region: Peptidase_M48; cl12018 471857000777 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 471857000778 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 471857000779 substrate binding site [chemical binding]; other site 471857000780 tetramer interface [polypeptide binding]; other site 471857000781 Protein of unknown function (DUF520); Region: DUF520; cl00723 471857000782 amidase; Provisional; Region: PRK06529 471857000783 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 471857000784 Domain of unknown function (DUF309); Region: DUF309; cl00667 471857000785 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 471857000786 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 471857000787 D-pathway; other site 471857000788 Putative ubiquinol binding site [chemical binding]; other site 471857000789 Low-spin heme (heme b) binding site [chemical binding]; other site 471857000790 Putative water exit pathway; other site 471857000791 Binuclear center (heme o3/CuB) [ion binding]; other site 471857000792 K-pathway; other site 471857000793 Putative proton exit pathway; other site 471857000794 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 471857000795 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 471857000796 GAF domain; Region: GAF; cl00853 471857000797 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 471857000798 metal binding site [ion binding]; metal-binding site 471857000799 active site 471857000800 I-site; other site 471857000801 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 471857000802 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 471857000803 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 471857000804 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 471857000805 active site 471857000806 catalytic site [active] 471857000807 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 471857000808 active site 471857000809 catalytic site [active] 471857000810 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 471857000811 active site 471857000812 catalytic triad [active] 471857000813 oxyanion hole [active] 471857000814 Predicted transcriptional regulators [Transcription]; Region: COG1725 471857000815 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857000816 DNA-binding site [nucleotide binding]; DNA binding site 471857000817 hypothetical protein; Validated; Region: PRK07682 471857000818 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471857000819 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857000820 homodimer interface [polypeptide binding]; other site 471857000821 catalytic residue [active] 471857000822 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 471857000823 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 471857000824 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 471857000825 putative homodimer interface [polypeptide binding]; other site 471857000826 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 471857000827 23S rRNA interface [nucleotide binding]; other site 471857000828 putative thiostrepton binding site; other site 471857000829 L7/L12 interface [polypeptide binding]; other site 471857000830 L25 interface [polypeptide binding]; other site 471857000831 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 471857000832 mRNA/rRNA interface [nucleotide binding]; other site 471857000833 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 471857000834 23S rRNA interface [nucleotide binding]; other site 471857000835 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 471857000836 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 471857000837 core dimer interface [polypeptide binding]; other site 471857000838 peripheral dimer interface [polypeptide binding]; other site 471857000839 L10 interface [polypeptide binding]; other site 471857000840 L11 interface [polypeptide binding]; other site 471857000841 putative EF-Tu interaction site [polypeptide binding]; other site 471857000842 putative EF-G interaction site [polypeptide binding]; other site 471857000843 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 471857000844 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 471857000845 Walker A/P-loop; other site 471857000846 ATP binding site [chemical binding]; other site 471857000847 Q-loop/lid; other site 471857000848 ABC transporter signature motif; other site 471857000849 Walker B; other site 471857000850 D-loop; other site 471857000851 H-loop/switch region; other site 471857000852 Domain of unknown function DUF140; Region: DUF140; cl00510 471857000853 Domain of unknown function DUF140; Region: DUF140; cl00510 471857000854 mce related protein; Region: MCE; pfam02470 471857000855 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 471857000856 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471857000857 mce related protein; Region: MCE; pfam02470 471857000858 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471857000859 mce related protein; Region: MCE; pfam02470 471857000860 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 471857000861 active site 2 [active] 471857000862 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471857000863 active site 1 [active] 471857000864 mce related protein; Region: MCE; pfam02470 471857000865 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471857000866 mce related protein; Region: MCE; pfam02470 471857000867 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences...; Region: SPEC; cl02488 471857000868 linker region; other site 471857000869 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471857000870 mce related protein; Region: MCE; pfam02470 471857000871 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 471857000872 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 471857000873 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 471857000874 RPB10 interaction site [polypeptide binding]; other site 471857000875 RPB1 interaction site [polypeptide binding]; other site 471857000876 RPB11 interaction site [polypeptide binding]; other site 471857000877 RPB3 interaction site [polypeptide binding]; other site 471857000878 RPB12 interaction site [polypeptide binding]; other site 471857000879 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 471857000880 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 471857000881 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 471857000882 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 471857000883 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 471857000884 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 471857000885 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 471857000886 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 471857000887 DNA binding site [nucleotide binding] 471857000888 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 471857000889 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 471857000890 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 471857000891 S17 interaction site [polypeptide binding]; other site 471857000892 S8 interaction site; other site 471857000893 16S rRNA interaction site [nucleotide binding]; other site 471857000894 streptomycin interaction site [chemical binding]; other site 471857000895 23S rRNA interaction site [nucleotide binding]; other site 471857000896 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 471857000897 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 471857000898 elongation factor G; Reviewed; Region: PRK00007 471857000899 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 471857000900 G1 box; other site 471857000901 putative GEF interaction site [polypeptide binding]; other site 471857000902 GTP/Mg2+ binding site [chemical binding]; other site 471857000903 Switch I region; other site 471857000904 G2 box; other site 471857000905 G3 box; other site 471857000906 Switch II region; other site 471857000907 G4 box; other site 471857000908 G5 box; other site 471857000909 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 471857000910 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 471857000911 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 471857000912 elongation factor Tu; Reviewed; Region: PRK00049 471857000913 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 471857000914 G1 box; other site 471857000915 GEF interaction site [polypeptide binding]; other site 471857000916 GTP/Mg2+ binding site [chemical binding]; other site 471857000917 Switch I region; other site 471857000918 G2 box; other site 471857000919 G3 box; other site 471857000920 Switch II region; other site 471857000921 G4 box; other site 471857000922 G5 box; other site 471857000923 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 471857000924 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 471857000925 Antibiotic Binding Site [chemical binding]; other site 471857000926 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 471857000927 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 471857000928 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 471857000929 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 471857000930 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 471857000931 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 471857000932 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 471857000933 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 471857000934 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 471857000935 putative translocon binding site; other site 471857000936 protein-rRNA interface [nucleotide binding]; other site 471857000937 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 471857000938 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 471857000939 G-X-X-G motif; other site 471857000940 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 471857000941 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 471857000942 23S rRNA interface [nucleotide binding]; other site 471857000943 5S rRNA interface [nucleotide binding]; other site 471857000944 putative antibiotic binding site [chemical binding]; other site 471857000945 L25 interface [polypeptide binding]; other site 471857000946 L27 interface [polypeptide binding]; other site 471857000947 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 471857000948 23S rRNA interface [nucleotide binding]; other site 471857000949 putative translocon interaction site; other site 471857000950 signal recognition particle (SRP54) interaction site; other site 471857000951 L23 interface [polypeptide binding]; other site 471857000952 trigger factor interaction site; other site 471857000953 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 471857000954 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 471857000955 KOW motif; Region: KOW; cl00354 471857000956 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 471857000957 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 471857000958 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 471857000959 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 471857000960 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 471857000961 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 471857000962 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 471857000963 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 471857000964 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 471857000965 5S rRNA interface [nucleotide binding]; other site 471857000966 L27 interface [polypeptide binding]; other site 471857000967 23S rRNA interface [nucleotide binding]; other site 471857000968 L5 interface [polypeptide binding]; other site 471857000969 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 471857000970 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 471857000971 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 471857000972 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658 471857000973 23S rRNA binding site [nucleotide binding]; other site 471857000974 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 471857000975 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 471857000976 SecY translocase; Region: SecY; pfam00344 471857000977 adenylate kinase; Reviewed; Region: adk; PRK00279 471857000978 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 471857000979 AMP-binding site [chemical binding]; other site 471857000980 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 471857000981 methionine aminopeptidase; Reviewed; Region: PRK07281 471857000982 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 471857000983 active site 471857000984 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 471857000985 rRNA binding site [nucleotide binding]; other site 471857000986 predicted 30S ribosome binding site; other site 471857000987 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 471857000988 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 471857000989 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 471857000990 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 471857000991 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 471857000992 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 471857000993 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471857000994 RNA binding surface [nucleotide binding]; other site 471857000995 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 471857000996 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 471857000997 alphaNTD homodimer interface [polypeptide binding]; other site 471857000998 alphaNTD - beta interaction site [polypeptide binding]; other site 471857000999 alphaNTD - beta' interaction site [polypeptide binding]; other site 471857001000 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 471857001001 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 471857001002 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 471857001003 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 471857001004 dimerization interface 3.5A [polypeptide binding]; other site 471857001005 active site 471857001006 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 471857001007 putative active site [active] 471857001008 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 471857001009 Protein of unknown function (DUF690); Region: DUF690; cl04939 471857001010 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 471857001011 active site 471857001012 catalytic residues [active] 471857001013 secretion protein snm4; Region: sec_mycoba_snm4; TIGR02958 471857001014 Protein of unknown function (DUF571); Region: DUF571; pfam04600 471857001015 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 471857001016 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857001017 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 471857001018 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857001019 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857001020 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 471857001021 C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 471857001022 Proteins of 100 residues with WXG; Region: WXG100; cl02005 471857001023 Proteins of 100 residues with WXG; Region: WXG100; cl02005 471857001024 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 471857001025 23S rRNA interface [nucleotide binding]; other site 471857001026 L3 interface [polypeptide binding]; other site 471857001027 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 471857001028 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 471857001029 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 471857001030 active site 471857001031 substrate binding site [chemical binding]; other site 471857001032 metal binding site [ion binding]; metal-binding site 471857001033 Proteins of 100 residues with WXG; Region: WXG100; cl02005 471857001034 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471857001035 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 471857001036 active site 471857001037 Chlorophyllase; Region: Chlorophyllase; cl15281 471857001038 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 471857001039 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 471857001040 glutaminase active site [active] 471857001041 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 471857001042 dimer interface [polypeptide binding]; other site 471857001043 active site 471857001044 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 471857001045 dimer interface [polypeptide binding]; other site 471857001046 active site 471857001047 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 471857001048 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 471857001049 putative substrate binding site [chemical binding]; other site 471857001050 putative ATP binding site [chemical binding]; other site 471857001051 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 471857001052 N- and C-terminal domain interface [polypeptide binding]; other site 471857001053 active site 471857001054 MgATP binding site [chemical binding]; other site 471857001055 catalytic site [active] 471857001056 metal binding site [ion binding]; metal-binding site 471857001057 carbohydrate binding site [chemical binding]; other site 471857001058 alanine racemase; Reviewed; Region: alr; PRK00053 471857001059 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 471857001060 active site 471857001061 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471857001062 dimer interface [polypeptide binding]; other site 471857001063 substrate binding site [chemical binding]; other site 471857001064 catalytic residues [active] 471857001065 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471857001066 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471857001067 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 471857001068 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 471857001069 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 471857001070 trimer interface [polypeptide binding]; other site 471857001071 active site 471857001072 substrate binding site [chemical binding]; other site 471857001073 CoA binding site [chemical binding]; other site 471857001074 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 471857001075 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 471857001076 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471857001077 putative glycoprotease GCP; Region: bact_gcp; TIGR03723 471857001078 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 471857001079 oligomerisation interface [polypeptide binding]; other site 471857001080 mobile loop; other site 471857001081 roof hairpin; other site 471857001082 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 471857001083 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 471857001084 ring oligomerisation interface [polypeptide binding]; other site 471857001085 ATP/Mg binding site [chemical binding]; other site 471857001086 stacking interactions; other site 471857001087 hinge regions; other site 471857001088 Transcription factor WhiB; Region: Whib; pfam02467 471857001089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 471857001090 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857001091 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471857001092 DNA binding residues [nucleotide binding] 471857001093 dimerization interface [polypeptide binding]; other site 471857001094 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 471857001095 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857001096 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471857001097 DNA binding residues [nucleotide binding] 471857001098 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 471857001099 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 471857001100 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 471857001101 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 471857001102 active site 471857001103 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 471857001104 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 471857001105 phosphate binding site [ion binding]; other site 471857001106 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 471857001107 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 471857001108 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 471857001109 GMP synthase; Reviewed; Region: guaA; PRK00074 471857001110 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 471857001111 AMP/PPi binding site [chemical binding]; other site 471857001112 candidate oxyanion hole; other site 471857001113 catalytic triad [active] 471857001114 potential glutamine specificity residues [chemical binding]; other site 471857001115 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 471857001116 ATP Binding subdomain [chemical binding]; other site 471857001117 Ligand Binding sites [chemical binding]; other site 471857001118 Dimerization subdomain; other site 471857001119 E3 Ubiquitin ligase; Region: GIDE; pfam12483 471857001120 PspC domain; Region: PspC; cl00864 471857001121 Predicted membrane protein (DUF2154); Region: DUF2154; cl12089 471857001122 PspC domain; Region: PspC; cl00864 471857001123 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471857001124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857001125 ATP binding site [chemical binding]; other site 471857001126 Mg2+ binding site [ion binding]; other site 471857001127 G-X-G motif; other site 471857001128 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857001129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471857001130 active site 471857001131 phosphorylation site [posttranslational modification] 471857001132 intermolecular recognition site; other site 471857001133 dimerization interface [polypeptide binding]; other site 471857001134 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471857001135 DNA binding residues [nucleotide binding] 471857001136 dimerization interface [polypeptide binding]; other site 471857001137 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471857001138 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471857001139 active site 471857001140 ATP binding site [chemical binding]; other site 471857001141 substrate binding site [chemical binding]; other site 471857001142 activation loop (A-loop); other site 471857001143 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471857001144 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471857001145 active site 471857001146 ATP binding site [chemical binding]; other site 471857001147 substrate binding site [chemical binding]; other site 471857001148 activation loop (A-loop); other site 471857001149 Chorismate mutase type II; Region: CM_2; cl00693 471857001150 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 471857001151 UvrD/REP helicase; Region: UvrD-helicase; cl14126 471857001152 Peptidase family M23; Region: Peptidase_M23; pfam01551 471857001153 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 471857001154 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 471857001155 CoA-ligase; Region: Ligase_CoA; pfam00549 471857001156 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 471857001157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857001158 CoA-ligase; Region: Ligase_CoA; pfam00549 471857001159 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 471857001160 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 471857001161 active site 471857001162 substrate binding site [chemical binding]; other site 471857001163 cosubstrate binding site; other site 471857001164 catalytic site [active] 471857001165 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 471857001166 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 471857001167 purine monophosphate binding site [chemical binding]; other site 471857001168 dimer interface [polypeptide binding]; other site 471857001169 putative catalytic residues [active] 471857001170 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 471857001171 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 471857001172 Protein of unknown function, DUF606; Region: DUF606; cl01273 471857001173 Protein of unknown function, DUF606; Region: DUF606; cl01273 471857001174 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 471857001175 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 471857001176 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 471857001177 homodimer interface [polypeptide binding]; other site 471857001178 NADP binding site [chemical binding]; other site 471857001179 substrate binding site [chemical binding]; other site 471857001180 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 471857001181 GtrA-like protein; Region: GtrA; cl00971 471857001182 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471857001183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857001184 putative substrate translocation pore; other site 471857001185 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 471857001186 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 471857001187 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 471857001188 putative active site [active] 471857001189 putative DNA binding site [nucleotide binding]; other site 471857001190 putative phosphate binding site [ion binding]; other site 471857001191 putative catalytic site [active] 471857001192 metal binding site A [ion binding]; metal-binding site 471857001193 putative AP binding site [nucleotide binding]; other site 471857001194 putative metal binding site B [ion binding]; other site 471857001195 Nuclease-related domain; Region: NERD; pfam08378 471857001196 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471857001197 active site 471857001198 ATP binding site [chemical binding]; other site 471857001199 substrate binding site [chemical binding]; other site 471857001200 activation loop (A-loop); other site 471857001201 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471857001202 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471857001203 active site 471857001204 ATP binding site [chemical binding]; other site 471857001205 substrate binding site [chemical binding]; other site 471857001206 activation loop (A-loop); other site 471857001207 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 471857001208 PglZ domain; Region: PglZ; pfam08665 471857001209 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 471857001210 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 471857001211 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471857001212 ATP binding site [chemical binding]; other site 471857001213 putative Mg++ binding site [ion binding]; other site 471857001214 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857001215 nucleotide binding region [chemical binding]; other site 471857001216 ATP-binding site [chemical binding]; other site 471857001217 Uncharacterised BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 471857001218 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 471857001219 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 471857001220 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 471857001221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857001222 putative substrate translocation pore; other site 471857001223 Beta-lactamase; Region: Beta-lactamase; cl01009 471857001224 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 471857001225 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 471857001226 Cellulose binding domain; Region: CBM_2; cl02709 471857001227 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 471857001228 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 471857001229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857001230 domain; Region: Succ_DH_flav_C; pfam02910 471857001231 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 471857001232 putative Iron-sulfur protein interface [polypeptide binding]; other site 471857001233 putative proximal heme binding site [chemical binding]; other site 471857001234 putative SdhC-like subunit interface [polypeptide binding]; other site 471857001235 putative distal heme binding site [chemical binding]; other site 471857001236 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 471857001237 putative Iron-sulfur protein interface [polypeptide binding]; other site 471857001238 putative proximal heme binding site [chemical binding]; other site 471857001239 putative SdhD-like interface [polypeptide binding]; other site 471857001240 putative distal heme binding site [chemical binding]; other site 471857001241 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 471857001242 ligand binding site [chemical binding]; other site 471857001243 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 471857001244 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 471857001245 Walker A/P-loop; other site 471857001246 ATP binding site [chemical binding]; other site 471857001247 Q-loop/lid; other site 471857001248 ABC transporter signature motif; other site 471857001249 Walker B; other site 471857001250 D-loop; other site 471857001251 H-loop/switch region; other site 471857001252 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 471857001253 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 471857001254 TM-ABC transporter signature motif; other site 471857001255 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 471857001256 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 471857001257 TM-ABC transporter signature motif; other site 471857001258 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 471857001259 active site 471857001260 catalytic motif [active] 471857001261 Zn binding site [ion binding]; other site 471857001262 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 471857001263 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 471857001264 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 471857001265 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 471857001266 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 471857001267 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 471857001268 active site 471857001269 ATP-dependent helicase; Provisional; Region: PRK13767 471857001270 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471857001271 ATP binding site [chemical binding]; other site 471857001272 putative Mg++ binding site [ion binding]; other site 471857001273 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 471857001274 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857001275 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 471857001276 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471857001277 NAD(P) binding site [chemical binding]; other site 471857001278 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 471857001279 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471857001280 NAD(P) binding site [chemical binding]; other site 471857001281 catalytic residues [active] 471857001282 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 471857001283 intersubunit interface [polypeptide binding]; other site 471857001284 active site 471857001285 catalytic residue [active] 471857001286 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 471857001287 Predicted membrane protein (DUF2154); Region: DUF2154; cl12089 471857001288 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 471857001289 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857001290 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857001291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857001292 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 471857001293 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 471857001294 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 471857001295 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 471857001296 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799 471857001297 active site 471857001298 substrate binding site [chemical binding]; other site 471857001299 metal binding site [ion binding]; metal-binding site 471857001300 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 471857001301 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg5; cd04780 471857001302 DNA binding residues [nucleotide binding] 471857001303 putative dimer interface [polypeptide binding]; other site 471857001304 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471857001305 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471857001306 active site 471857001307 ATP binding site [chemical binding]; other site 471857001308 substrate binding site [chemical binding]; other site 471857001309 activation loop (A-loop); other site 471857001310 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 471857001311 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 471857001312 heterodimer interface [polypeptide binding]; other site 471857001313 substrate interaction site [chemical binding]; other site 471857001314 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 471857001315 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 471857001316 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily...; Region: MM_CoA_mutase_alpha_like; cd03679 471857001317 active site 471857001318 substrate binding site [chemical binding]; other site 471857001319 coenzyme B12 binding site [chemical binding]; other site 471857001320 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen...; Region: MM_CoA_mut_B12_BD; cd02071 471857001321 B12 binding site [chemical binding]; other site 471857001322 cobalt ligand [ion binding]; other site 471857001323 membrane ATPase/protein kinase; Provisional; Region: PRK09435 471857001324 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 471857001325 Walker A; other site 471857001326 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 471857001327 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 471857001328 metal binding site [ion binding]; metal-binding site 471857001329 putative dimer interface [polypeptide binding]; other site 471857001330 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 471857001331 putative active site pocket [active] 471857001332 dimerization interface [polypeptide binding]; other site 471857001333 putative catalytic residue [active] 471857001334 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 471857001335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857001336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857001337 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471857001338 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 471857001339 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 471857001340 glycerol kinase; Provisional; Region: glpK; PRK00047 471857001341 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 471857001342 N- and C-terminal domain interface [polypeptide binding]; other site 471857001343 putative active site [active] 471857001344 putative MgATP binding site [chemical binding]; other site 471857001345 catalytic site [active] 471857001346 metal binding site [ion binding]; metal-binding site 471857001347 putative homotetramer interface [polypeptide binding]; other site 471857001348 putative glycerol binding site [chemical binding]; other site 471857001349 homodimer interface [polypeptide binding]; other site 471857001350 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cl00200 471857001351 amphipathic channel; other site 471857001352 Asn-Pro-Ala signature motifs; other site 471857001353 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 471857001354 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 471857001355 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 471857001356 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 471857001357 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 471857001358 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471857001359 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 471857001360 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 471857001361 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 471857001362 carboxyltransferase (CT) interaction site; other site 471857001363 biotinylation site [posttranslational modification]; other site 471857001364 Maf-like protein; Region: Maf; pfam02545 471857001365 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 471857001366 active site 471857001367 dimer interface [polypeptide binding]; other site 471857001368 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 471857001369 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 471857001370 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 471857001371 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 471857001372 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 471857001373 Predicted membrane protein [Function unknown]; Region: COG3428 471857001374 Bacterial membrane flanked domain; Region: DUF304; cl01348 471857001375 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 471857001376 active site 471857001377 catalytic residues [active] 471857001378 metal binding site [ion binding]; metal-binding site 471857001379 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 471857001380 active site 471857001381 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471857001382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471857001383 active site 471857001384 phosphorylation site [posttranslational modification] 471857001385 intermolecular recognition site; other site 471857001386 dimerization interface [polypeptide binding]; other site 471857001387 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 471857001388 DNA binding site [nucleotide binding] 471857001389 two-component sensor protein; Provisional; Region: cpxA; PRK09470 471857001390 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 471857001391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857001392 ATP binding site [chemical binding]; other site 471857001393 Mg2+ binding site [ion binding]; other site 471857001394 G-X-G motif; other site 471857001395 GtrA-like protein; Region: GtrA; cl00971 471857001396 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471857001397 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857001398 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471857001399 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 471857001400 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 471857001401 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 471857001402 AIR carboxylase; Region: AIRC; cl00310 471857001403 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857001404 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 471857001405 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857001406 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 471857001407 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 471857001408 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 471857001409 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 471857001410 NAD binding site [chemical binding]; other site 471857001411 substrate binding site [chemical binding]; other site 471857001412 homodimer interface [polypeptide binding]; other site 471857001413 active site 471857001414 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 471857001415 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 471857001416 NADP binding site [chemical binding]; other site 471857001417 active site 471857001418 putative substrate binding site [chemical binding]; other site 471857001419 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 471857001420 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 471857001421 Probable Catalytic site [active] 471857001422 metal binding site [ion binding]; metal-binding site 471857001423 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471857001424 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 471857001425 Probable Catalytic site [active] 471857001426 metal binding site [ion binding]; metal-binding site 471857001427 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 471857001428 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471857001429 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 471857001430 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471857001431 active site 471857001432 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471857001433 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 471857001434 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 471857001435 active site 471857001436 Substrate binding site [chemical binding]; other site 471857001437 Mg++ binding site [ion binding]; other site 471857001438 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 471857001439 N-terminal domain interface [polypeptide binding]; other site 471857001440 sulfate 1 binding site; other site 471857001441 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 471857001442 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 471857001443 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 471857001444 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 471857001445 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 471857001446 nudix motif; other site 471857001447 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 471857001448 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 471857001449 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 471857001450 FMN binding site [chemical binding]; other site 471857001451 dimer interface [polypeptide binding]; other site 471857001452 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 471857001453 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 471857001454 dimer interface [polypeptide binding]; other site 471857001455 substrate binding site [chemical binding]; other site 471857001456 phosphate binding site [ion binding]; other site 471857001457 Ferredoxin [Energy production and conversion]; Region: COG1146 471857001458 4Fe-4S binding domain; Region: Fer4; cl02805 471857001459 aspartate aminotransferase; Provisional; Region: PRK07681 471857001460 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471857001461 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857001462 homodimer interface [polypeptide binding]; other site 471857001463 catalytic residue [active] 471857001464 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 471857001465 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 471857001466 putative trimer interface [polypeptide binding]; other site 471857001467 putative CoA binding site [chemical binding]; other site 471857001468 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 471857001469 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 471857001470 metal binding site [ion binding]; metal-binding site 471857001471 putative dimer interface [polypeptide binding]; other site 471857001472 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 471857001473 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 471857001474 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471857001475 putative acyl-acceptor binding pocket; other site 471857001476 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471857001477 DivIVA domain; Region: DivI1A_domain; TIGR03544 471857001478 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 471857001479 hydrophobic ligand binding site; other site 471857001480 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 471857001481 enoyl-CoA hydratase; Provisional; Region: PRK06688 471857001482 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471857001483 substrate binding site [chemical binding]; other site 471857001484 oxyanion hole (OAH) forming residues; other site 471857001485 trimer interface [polypeptide binding]; other site 471857001486 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 471857001487 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 471857001488 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 471857001489 interface (dimer of trimers) [polypeptide binding]; other site 471857001490 Substrate-binding/catalytic site; other site 471857001491 Zn-binding sites [ion binding]; other site 471857001492 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857001493 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 471857001494 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 471857001495 putative dimerization interface [polypeptide binding]; other site 471857001496 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471857001497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857001498 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 471857001499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471857001500 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 471857001501 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857001502 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471857001503 DNA binding residues [nucleotide binding] 471857001504 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 471857001505 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 471857001506 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 471857001507 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 471857001508 Domain of unknown function DUF59; Region: DUF59; cl00941 471857001509 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 471857001510 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 471857001511 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471857001512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857001513 dimer interface [polypeptide binding]; other site 471857001514 conserved gate region; other site 471857001515 putative PBP binding loops; other site 471857001516 ABC-ATPase subunit interface; other site 471857001517 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471857001518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857001519 dimer interface [polypeptide binding]; other site 471857001520 conserved gate region; other site 471857001521 putative PBP binding loops; other site 471857001522 ABC-ATPase subunit interface; other site 471857001523 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 471857001524 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 471857001525 Walker A/P-loop; other site 471857001526 ATP binding site [chemical binding]; other site 471857001527 Q-loop/lid; other site 471857001528 ABC transporter signature motif; other site 471857001529 Walker B; other site 471857001530 D-loop; other site 471857001531 H-loop/switch region; other site 471857001532 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 471857001533 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 471857001534 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837 471857001535 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 471857001536 nudix motif; other site 471857001537 Bacterial membrane flanked domain; Region: DUF304; cl01348 471857001538 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 471857001539 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 471857001540 MarC family integral membrane protein; Region: MarC; cl00919 471857001541 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 471857001542 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471857001543 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 471857001544 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 471857001545 DEAD-like helicases superfamily; Region: DEXDc; smart00487 471857001546 ATP binding site [chemical binding]; other site 471857001547 Mg++ binding site [ion binding]; other site 471857001548 motif III; other site 471857001549 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857001550 nucleotide binding region [chemical binding]; other site 471857001551 ATP-binding site [chemical binding]; other site 471857001552 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 471857001553 dinuclear metal binding motif [ion binding]; other site 471857001554 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 471857001555 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857001556 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857001557 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 471857001558 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471857001559 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857001560 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857001561 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 471857001562 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 471857001563 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 471857001564 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 471857001565 ATP binding site [chemical binding]; other site 471857001566 substrate interface [chemical binding]; other site 471857001567 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471857001568 active site residue [active] 471857001569 TIGR02569 family protein; Region: TIGR02569_actnb 471857001570 Putative esterase; Region: Esterase; pfam00756 471857001571 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471857001572 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 471857001573 FAD binding pocket [chemical binding]; other site 471857001574 FAD binding motif [chemical binding]; other site 471857001575 phosphate binding motif [ion binding]; other site 471857001576 NAD binding pocket [chemical binding]; other site 471857001577 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 471857001578 DNA binding site [nucleotide binding] 471857001579 active site 471857001580 UvrD/REP helicase; Region: UvrD-helicase; cl14126 471857001581 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 471857001582 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 471857001583 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 471857001584 UvrD/REP helicase; Region: UvrD-helicase; cl14126 471857001585 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 471857001586 Ion channel; Region: Ion_trans_2; cl11596 471857001587 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 471857001588 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857001589 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 471857001590 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 471857001591 active site 471857001592 catalytic triad [active] 471857001593 oxyanion hole [active] 471857001594 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 471857001595 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 471857001596 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471857001597 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 471857001598 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 471857001599 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471857001600 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 471857001601 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 471857001602 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 471857001603 putative NADH binding site [chemical binding]; other site 471857001604 putative active site [active] 471857001605 nudix motif; other site 471857001606 putative metal binding site [ion binding]; other site 471857001607 CobD/Cbib protein; Region: CobD_Cbib; cl00561 471857001608 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 471857001609 Phosphotransferase enzyme family; Region: APH; pfam01636 471857001610 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471857001611 Low molecular weight phosphatase family; Region: LMWPc; cd00115 471857001612 Active site [active] 471857001613 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471857001614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857001615 ATP binding site [chemical binding]; other site 471857001616 Mg2+ binding site [ion binding]; other site 471857001617 G-X-G motif; other site 471857001618 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 471857001619 Protein of unknown function (DUF742); Region: DUF742; pfam05331 471857001620 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 471857001621 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471857001622 Uncharacterized conserved protein [Function unknown]; Region: COG0327 471857001623 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 471857001624 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471857001625 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857001626 homogentisate 1,2-dioxygenase; Region: HgmA; cl10473 471857001627 fumarylacetoacetase; Region: PLN02856 471857001628 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 471857001629 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 471857001630 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 471857001631 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 471857001632 metabolite-proton symporter; Region: 2A0106; TIGR00883 471857001633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857001634 Cytochrome P450; Region: p450; cl12078 471857001635 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 471857001636 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-...; Region: PDR_like; cd06185 471857001637 FMN-binding pocket [chemical binding]; other site 471857001638 flavin binding motif; other site 471857001639 phosphate binding motif [ion binding]; other site 471857001640 beta-alpha-beta structure motif; other site 471857001641 NAD binding pocket [chemical binding]; other site 471857001642 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471857001643 catalytic loop [active] 471857001644 iron binding site [ion binding]; other site 471857001645 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 471857001646 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 471857001647 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 471857001648 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 471857001649 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 471857001650 Glucuronate isomerase; Region: UxaC; cl00829 471857001651 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 471857001652 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471857001653 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471857001654 DNA binding site [nucleotide binding] 471857001655 domain linker motif; other site 471857001656 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471857001657 dimerization interface [polypeptide binding]; other site 471857001658 ligand binding site [chemical binding]; other site 471857001659 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 471857001660 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857001661 Walker A/P-loop; other site 471857001662 ATP binding site [chemical binding]; other site 471857001663 Q-loop/lid; other site 471857001664 ABC transporter signature motif; other site 471857001665 Walker B; other site 471857001666 D-loop; other site 471857001667 H-loop/switch region; other site 471857001668 TOBE domain; Region: TOBE_2; cl01440 471857001669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857001670 dimer interface [polypeptide binding]; other site 471857001671 conserved gate region; other site 471857001672 putative PBP binding loops; other site 471857001673 ABC-ATPase subunit interface; other site 471857001674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857001675 dimer interface [polypeptide binding]; other site 471857001676 conserved gate region; other site 471857001677 putative PBP binding loops; other site 471857001678 ABC-ATPase subunit interface; other site 471857001679 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 471857001680 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 471857001681 putative active site pocket [active] 471857001682 putative metal binding site [ion binding]; other site 471857001683 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 471857001684 substrate binding site [chemical binding]; other site 471857001685 ATP binding site [chemical binding]; other site 471857001686 galactarate dehydratase; Region: galactar-dH20; TIGR03248 471857001687 SAF domain; Region: SAF; cl00555 471857001688 SAF domain; Region: SAF; cl00555 471857001689 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 471857001690 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 471857001691 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 471857001692 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471857001693 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857001694 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 471857001695 Putative zinc ribbon domain; Region: DUF164; pfam02591 471857001696 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 471857001697 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 471857001698 RNA/DNA hybrid binding site [nucleotide binding]; other site 471857001699 active site 471857001700 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471857001701 catalytic core [active] 471857001702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471857001703 AAA-like domain; Region: AAA_10; pfam12846 471857001704 NlpC/P60 family; Region: NLPC_P60; cl11438 471857001705 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 471857001706 intersubunit interface [polypeptide binding]; other site 471857001707 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 471857001708 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 471857001709 oligomerization interface [polypeptide binding]; other site 471857001710 active site 471857001711 metal binding site [ion binding]; metal-binding site 471857001712 DinB superfamily; Region: DinB_2; cl00986 471857001713 NAD synthetase; Provisional; Region: PRK13981 471857001714 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 471857001715 multimer interface [polypeptide binding]; other site 471857001716 active site 471857001717 catalytic triad [active] 471857001718 protein interface 1 [polypeptide binding]; other site 471857001719 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 471857001720 homodimer interface [polypeptide binding]; other site 471857001721 NAD binding pocket [chemical binding]; other site 471857001722 ATP binding pocket [chemical binding]; other site 471857001723 Mg binding site [ion binding]; other site 471857001724 active-site loop [active] 471857001725 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 471857001726 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 471857001727 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857001728 nucleotide binding region [chemical binding]; other site 471857001729 ATP-binding site [chemical binding]; other site 471857001730 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 471857001731 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471857001732 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 471857001733 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 471857001734 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 471857001735 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 471857001736 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 471857001737 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 471857001738 catalytic triad [active] 471857001739 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 471857001740 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 471857001741 metal binding triad; other site 471857001742 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 471857001743 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 471857001744 metal binding triad; other site 471857001745 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 471857001746 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 471857001747 active site 471857001748 glutamine synthetase, type I; Region: GlnA; TIGR00653 471857001749 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 471857001750 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 471857001751 RDD family; Region: RDD; cl00746 471857001752 UvrD/REP helicase; Region: UvrD-helicase; cl14126 471857001753 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 471857001754 HRDC domain; Region: HRDC; cl02578 471857001755 Transcription factor WhiB; Region: Whib; pfam02467 471857001756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471857001757 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 471857001758 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471857001759 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 471857001760 active site 471857001761 ATP binding site [chemical binding]; other site 471857001762 Protein of unknown function DUF45; Region: DUF45; cl00636 471857001763 Uncharacterised conserved protein (DUF2342); Region: DUF2342; cl02183 471857001764 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 471857001765 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated...; Region: PDZ; cl00117 471857001766 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 471857001767 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 471857001768 Uncharacterised protein family (UPF0182); Region: UPF0182; pfam03699 471857001769 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857001770 peptide chain release factor 2; Validated; Region: prfB; PRK00578 471857001771 RF-1 domain; Region: RF-1; cl02875 471857001772 RF-1 domain; Region: RF-1; cl02875 471857001773 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 471857001774 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857001775 Walker A/P-loop; other site 471857001776 ATP binding site [chemical binding]; other site 471857001777 Q-loop/lid; other site 471857001778 ABC transporter signature motif; other site 471857001779 Walker B; other site 471857001780 D-loop; other site 471857001781 H-loop/switch region; other site 471857001782 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 471857001783 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 471857001784 SmpB-tmRNA interface; other site 471857001785 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cd01292 471857001786 active site 471857001787 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 471857001788 Dienelactone hydrolase family; Region: DLH; pfam01738 471857001789 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 471857001790 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471857001791 ATP binding site [chemical binding]; other site 471857001792 putative Mg++ binding site [ion binding]; other site 471857001793 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857001794 nucleotide binding region [chemical binding]; other site 471857001795 ATP-binding site [chemical binding]; other site 471857001796 Helicase associated domain (HA2); Region: HA2; cl04503 471857001797 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 471857001798 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 471857001799 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 471857001800 substrate binding pocket [chemical binding]; other site 471857001801 membrane-bound complex binding site; other site 471857001802 hinge residues; other site 471857001803 Methylamine utilisation protein MauE; Region: MauE; pfam07291 471857001804 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471857001805 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 471857001806 NlpC/P60 family; Region: NLPC_P60; cl11438 471857001807 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471857001808 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 471857001809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857001810 putative substrate translocation pore; other site 471857001811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857001812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 471857001813 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471857001814 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471857001815 TspO/MBR family; Region: TspO_MBR; cl01379 471857001816 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 471857001817 Acylphosphatase; Region: Acylphosphatase; cl00551 471857001818 HypF finger; Region: zf-HYPF; pfam07503 471857001819 HypF finger; Region: zf-HYPF; pfam07503 471857001820 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 471857001821 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471857001822 Hydrogenase expression/synthesis hypA family; Region: HypA; cl00418 471857001823 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 471857001824 dimerization interface [polypeptide binding]; other site 471857001825 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 471857001826 ATP binding site [chemical binding]; other site 471857001827 Hydrogenase formation hypA family; Region: HypD; cl12072 471857001828 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409 471857001829 HupF/HypC family; Region: HupF_HypC; cl00394 471857001830 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 471857001831 Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068 471857001832 nickel binding site [ion binding]; other site 471857001833 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 471857001834 dimer interface [polypeptide binding]; other site 471857001835 active site 471857001836 HupF/HypC family; Region: HupF_HypC; cl00394 471857001837 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 471857001838 dimer interface [polypeptide binding]; other site 471857001839 active site 471857001840 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 471857001841 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 471857001842 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471857001843 Transcription factor WhiB; Region: Whib; pfam02467 471857001844 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471857001845 FOG: CBS domain [General function prediction only]; Region: COG0517 471857001846 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_9; cd04622 471857001847 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 471857001848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471857001849 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 471857001850 anchoring element; other site 471857001851 dimer interface [polypeptide binding]; other site 471857001852 ATP binding site [chemical binding]; other site 471857001853 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 471857001854 active site 471857001855 metal binding site [ion binding]; metal-binding site 471857001856 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 471857001857 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 471857001858 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 471857001859 CAP-like domain; other site 471857001860 Active site [active] 471857001861 primary dimer interface [polypeptide binding]; other site 471857001862 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471857001863 Ligand Binding Site [chemical binding]; other site 471857001864 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471857001865 Ligand Binding Site [chemical binding]; other site 471857001866 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 471857001867 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 471857001868 Domain of unknown function DUF20; Region: UPF0118; cl00465 471857001869 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 471857001870 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 471857001871 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 471857001872 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 471857001873 ATP binding site [chemical binding]; other site 471857001874 active site 471857001875 substrate binding site [chemical binding]; other site 471857001876 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 471857001877 UbiA prenyltransferase family; Region: UbiA; cl00337 471857001878 Cytochrome P450; Region: p450; cl12078 471857001879 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 471857001880 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 471857001881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471857001882 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471857001883 FAD binding domain; Region: FAD_binding_4; pfam01565 471857001884 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471857001885 DNA binding residues [nucleotide binding] 471857001886 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 471857001887 argininosuccinate lyase; Provisional; Region: PRK02186 471857001888 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 471857001889 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 471857001890 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471857001891 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 471857001892 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 471857001893 C-term; Region: GreA_GreB; pfam01272 471857001894 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 471857001895 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 471857001896 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 471857001897 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685 471857001898 RNA binding site [nucleotide binding]; other site 471857001899 Dehydratase family; Region: ILVD_EDD; cl00340 471857001900 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 471857001901 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 471857001902 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471857001903 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 471857001904 catalytic triad [active] 471857001905 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 471857001906 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 471857001907 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 471857001908 putative dimer interface [polypeptide binding]; other site 471857001909 active site pocket [active] 471857001910 putative cataytic base [active] 471857001911 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857001912 ATP binding site [chemical binding]; other site 471857001913 Walker B motif; other site 471857001914 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471857001915 FAD binding domain; Region: FAD_binding_4; pfam01565 471857001916 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 471857001917 Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism; Region: HOT; cd08190 471857001918 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 471857001919 putative active site [active] 471857001920 metal binding site [ion binding]; metal-binding site 471857001921 Transcriptional regulators [Transcription]; Region: GntR; COG1802 471857001922 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857001923 DNA-binding site [nucleotide binding]; DNA binding site 471857001924 FCD domain; Region: FCD; cl11656 471857001925 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 471857001926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857001927 putative substrate translocation pore; other site 471857001928 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471857001929 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 471857001930 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471857001931 catalytic residue [active] 471857001932 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 471857001933 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 471857001934 acyl-CoA synthetase; Validated; Region: PRK08316 471857001935 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857001936 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471857001937 Predicted amidohydrolase [General function prediction only]; Region: COG0388 471857001938 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586 471857001939 putative active site [active] 471857001940 catalytic triad [active] 471857001941 putative dimer interface [polypeptide binding]; other site 471857001942 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step...; Region: CIMS_like; cd03310 471857001943 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 471857001944 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 471857001945 nucleotide binding pocket [chemical binding]; other site 471857001946 K-X-D-G motif; other site 471857001947 catalytic site [active] 471857001948 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 471857001949 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 471857001950 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 471857001951 Dimer interface [polypeptide binding]; other site 471857001952 BRCT sequence motif; other site 471857001953 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 471857001954 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471857001955 Coenzyme A binding pocket [chemical binding]; other site 471857001956 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 471857001957 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 471857001958 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 471857001959 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 471857001960 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 471857001961 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 471857001962 GatB domain; Region: GatB_Yqey; cl11497 471857001963 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 471857001964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857001965 RHS Repeat; Region: RHS_repeat; cl11982 471857001966 RHS Repeat; Region: RHS_repeat; cl11982 471857001967 RHS Repeat; Region: RHS_repeat; cl11982 471857001968 RHS Repeat; Region: RHS_repeat; cl11982 471857001969 RHS Repeat; Region: RHS_repeat; cl11982 471857001970 RHS Repeat; Region: RHS_repeat; cl11982 471857001971 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 471857001972 RHS Repeat; Region: RHS_repeat; cl11982 471857001973 RHS Repeat; Region: RHS_repeat; cl11982 471857001974 RHS Repeat; Region: RHS_repeat; cl11982 471857001975 RHS Repeat; Region: RHS_repeat; cl11982 471857001976 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 471857001977 DoxX; Region: DoxX; cl00976 471857001978 Dehydratase family; Region: ILVD_EDD; cl00340 471857001979 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 471857001980 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 471857001981 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 471857001982 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 471857001983 PYR/PP interface [polypeptide binding]; other site 471857001984 dimer interface [polypeptide binding]; other site 471857001985 TPP binding site [chemical binding]; other site 471857001986 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 471857001987 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 471857001988 TPP-binding site [chemical binding]; other site 471857001989 dimer interface [polypeptide binding]; other site 471857001990 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 471857001991 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 471857001992 putative valine binding site [chemical binding]; other site 471857001993 dimer interface [polypeptide binding]; other site 471857001994 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 471857001995 ketol-acid reductoisomerase; Provisional; Region: PRK05479 471857001996 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857001997 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 471857001998 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471857001999 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 471857002000 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857002001 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 471857002002 putative L-serine binding site [chemical binding]; other site 471857002003 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 471857002004 isocitrate dehydrogenase; Validated; Region: PRK06451 471857002005 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 471857002006 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 471857002007 active site 471857002008 catalytic residues [active] 471857002009 metal binding site [ion binding]; metal-binding site 471857002010 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 471857002011 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 471857002012 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 471857002013 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 471857002014 hypothetical protein; Provisional; Region: PRK06185 471857002015 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857002016 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857002017 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 471857002018 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 471857002019 HIGH motif; other site 471857002020 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 471857002021 active site 471857002022 KMSKS motif; other site 471857002023 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 471857002024 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 471857002025 motif II; other site 471857002026 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857002027 Bacterial transcriptional regulator; Region: IclR; pfam01614 471857002028 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 471857002029 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 471857002030 substrate binding site [chemical binding]; other site 471857002031 ligand binding site [chemical binding]; other site 471857002032 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 471857002033 substrate binding site [chemical binding]; other site 471857002034 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 471857002035 active site 471857002036 Ap6A binding site [chemical binding]; other site 471857002037 nudix motif; other site 471857002038 metal binding site [ion binding]; metal-binding site 471857002039 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471857002040 catalytic core [active] 471857002041 polyphosphate kinase; Provisional; Region: PRK05443 471857002042 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 471857002043 putative domain interface [polypeptide binding]; other site 471857002044 putative active site [active] 471857002045 catalytic site [active] 471857002046 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 471857002047 putative domain interface [polypeptide binding]; other site 471857002048 putative active site [active] 471857002049 catalytic site [active] 471857002050 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471857002051 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471857002052 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471857002053 putative acyl-acceptor binding pocket; other site 471857002054 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 471857002055 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857002056 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 471857002057 Cysteine dioxygenase type I; Region: CDO_I; cl02350 471857002058 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 471857002059 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857002060 DNA-binding site [nucleotide binding]; DNA binding site 471857002061 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471857002062 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471857002063 catalytic residue [active] 471857002064 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 471857002065 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 471857002066 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 471857002067 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 471857002068 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857002069 thiamine monophosphate kinase; Provisional; Region: PRK05731 471857002070 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 471857002071 ATP binding site [chemical binding]; other site 471857002072 dimerization interface [polypeptide binding]; other site 471857002073 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471857002074 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471857002075 Coenzyme A binding pocket [chemical binding]; other site 471857002076 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 471857002077 ligand binding site [chemical binding]; other site 471857002078 active site 471857002079 UGI interface [polypeptide binding]; other site 471857002080 catalytic site [active] 471857002081 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 471857002082 DAK2 domain; Region: Dak2; cl03685 471857002083 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 471857002084 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 471857002085 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 471857002086 generic binding surface II; other site 471857002087 ssDNA binding site; other site 471857002088 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471857002089 ATP binding site [chemical binding]; other site 471857002090 putative Mg++ binding site [ion binding]; other site 471857002091 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857002092 nucleotide binding region [chemical binding]; other site 471857002093 ATP-binding site [chemical binding]; other site 471857002094 pyruvate carboxylase; Reviewed; Region: PRK12999 471857002095 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471857002096 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 471857002097 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 471857002098 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 471857002099 active site 471857002100 catalytic residues [active] 471857002101 metal binding site [ion binding]; metal-binding site 471857002102 homodimer binding site [polypeptide binding]; other site 471857002103 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 471857002104 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 471857002105 carboxyltransferase (CT) interaction site; other site 471857002106 biotinylation site [posttranslational modification]; other site 471857002107 Arginase family; Region: Arginase; cl00306 471857002108 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 471857002109 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471857002110 mce related protein; Region: MCE; pfam02470 471857002111 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471857002112 mce related protein; Region: MCE; pfam02470 471857002113 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471857002114 mce related protein; Region: MCE; pfam02470 471857002115 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471857002116 mce related protein; Region: MCE; pfam02470 471857002117 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471857002118 mce related protein; Region: MCE; pfam02470 471857002119 mce related protein; Region: MCE; pfam02470 471857002120 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 471857002121 Domain of unknown function DUF140; Region: DUF140; cl00510 471857002122 Domain of unknown function DUF140; Region: DUF140; cl00510 471857002123 RNA polymerase factor sigma-54; Provisional; Region: PRK12469 471857002124 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the...; Region: mcbC-like_oxidoreductase; cd02142 471857002125 putative FMN binding site [chemical binding]; other site 471857002126 NADPH bind site [chemical binding]; other site 471857002127 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 471857002128 UvrD/REP helicase; Region: UvrD-helicase; cl14126 471857002129 UvrD/REP helicase; Region: UvrD-helicase; cl14126 471857002130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471857002131 S-adenosylmethionine binding site [chemical binding]; other site 471857002132 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 471857002133 active site 471857002134 (T/H)XGH motif; other site 471857002135 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 471857002136 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 471857002137 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 471857002138 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 471857002139 ribonuclease III; Reviewed; Region: rnc; PRK00102 471857002140 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 471857002141 dimerization interface [polypeptide binding]; other site 471857002142 active site 471857002143 metal binding site [ion binding]; metal-binding site 471857002144 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 471857002145 dsRNA binding site [nucleotide binding]; other site 471857002146 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 471857002147 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 471857002148 DNA binding site [nucleotide binding] 471857002149 catalytic residue [active] 471857002150 H2TH interface [polypeptide binding]; other site 471857002151 putative catalytic residues [active] 471857002152 turnover-facilitating residue; other site 471857002153 intercalation triad [nucleotide binding]; other site 471857002154 8OG recognition residue [nucleotide binding]; other site 471857002155 putative reading head residues; other site 471857002156 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 471857002157 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 471857002158 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857002159 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 471857002160 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471857002161 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471857002162 Acylphosphatase; Region: Acylphosphatase; cl00551 471857002163 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 471857002164 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 471857002165 Walker A/P-loop; other site 471857002166 ATP binding site [chemical binding]; other site 471857002167 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 471857002168 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 471857002169 ABC transporter signature motif; other site 471857002170 Walker B; other site 471857002171 D-loop; other site 471857002172 H-loop/switch region; other site 471857002173 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 471857002174 Sodium:solute symporter family; Region: SSF; cl00456 471857002175 Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217 471857002176 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 471857002177 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 471857002178 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471857002179 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 471857002180 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471857002181 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857002182 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471857002183 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857002184 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471857002185 Bacterial transcriptional regulator; Region: IclR; pfam01614 471857002186 malate synthase A; Region: malate_syn_A; TIGR01344 471857002187 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 471857002188 active site 471857002189 LamB/YcsF family; Region: LamB_YcsF; cl00664 471857002190 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471857002191 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 471857002192 signal recognition particle protein; Provisional; Region: PRK10867 471857002193 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 471857002194 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 471857002195 P loop; other site 471857002196 GTP binding site [chemical binding]; other site 471857002197 Signal peptide binding domain; Region: SRP_SPB; pfam02978 471857002198 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 471857002199 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 471857002200 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 471857002201 active site 471857002202 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 471857002203 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 471857002204 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 471857002205 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794 471857002206 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 471857002207 RimM N-terminal domain; Region: RimM; pfam01782 471857002208 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 471857002209 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 471857002210 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 471857002211 Catalytic site [active] 471857002212 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 471857002213 RNA/DNA hybrid binding site [nucleotide binding]; other site 471857002214 active site 471857002215 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 471857002216 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 471857002217 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 471857002218 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857002219 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 471857002220 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 471857002221 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471857002222 DNA binding site [nucleotide binding] 471857002223 Int/Topo IB signature motif; other site 471857002224 active site 471857002225 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 471857002226 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857002227 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471857002228 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471857002229 DNA binding residues [nucleotide binding] 471857002230 Peptidase family M23; Region: Peptidase_M23; pfam01551 471857002231 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 471857002232 rRNA interaction site [nucleotide binding]; other site 471857002233 S8 interaction site; other site 471857002234 elongation factor Ts; Provisional; Region: tsf; PRK09377 471857002235 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 471857002236 Elongation factor TS; Region: EF_TS; pfam00889 471857002237 Elongation factor TS; Region: EF_TS; pfam00889 471857002238 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 471857002239 putative nucleotide binding site [chemical binding]; other site 471857002240 uridine monophosphate binding site [chemical binding]; other site 471857002241 homohexameric interface [polypeptide binding]; other site 471857002242 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 471857002243 hinge region; other site 471857002244 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 471857002245 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 471857002246 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 471857002247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471857002248 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 471857002249 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 471857002250 FeS/SAM binding site; other site 471857002251 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 471857002252 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 471857002253 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 471857002254 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 471857002255 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 471857002256 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 471857002257 active site 471857002258 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 471857002259 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 471857002260 putative substrate binding region [chemical binding]; other site 471857002261 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 471857002262 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 471857002263 Predicted acetyltransferase [General function prediction only]; Region: COG3393 471857002264 methionine aminopeptidase; Reviewed; Region: PRK07281 471857002265 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 471857002266 active site 471857002267 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857002268 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 471857002269 NAD(P) binding site [chemical binding]; other site 471857002270 active site 471857002271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857002272 metabolite-proton symporter; Region: 2A0106; TIGR00883 471857002273 putative substrate translocation pore; other site 471857002274 GAF domain; Region: GAF; cl00853 471857002275 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 471857002276 transcriptional regulator NanR; Provisional; Region: PRK03837 471857002277 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857002278 DNA-binding site [nucleotide binding]; DNA binding site 471857002279 FCD domain; Region: FCD; cl11656 471857002280 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 471857002281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857002282 mycothione reductase; Reviewed; Region: PRK07846 471857002283 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857002284 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471857002285 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cd00190 471857002286 cleavage site 471857002287 active site 471857002288 substrate binding sites [chemical binding]; other site 471857002289 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471857002290 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 471857002291 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471857002292 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471857002293 catalytic residue [active] 471857002294 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 471857002295 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 471857002296 DEAD-like helicases superfamily; Region: DEXDc; smart00487 471857002297 ATP binding site [chemical binding]; other site 471857002298 Mg++ binding site [ion binding]; other site 471857002299 motif III; other site 471857002300 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857002301 nucleotide binding region [chemical binding]; other site 471857002302 ATP-binding site [chemical binding]; other site 471857002303 FAD dependent oxidoreductase; Region: DAO; pfam01266 471857002304 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 471857002305 Protein of unknown function (DUF328); Region: DUF328; cl01143 471857002306 prolyl-tRNA synthetase; Provisional; Region: PRK09194 471857002307 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 471857002308 dimer interface [polypeptide binding]; other site 471857002309 motif 1; other site 471857002310 active site 471857002311 motif 2; other site 471857002312 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 471857002313 putative deacylase active site [active] 471857002314 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 471857002315 active site 471857002316 motif 3; other site 471857002317 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 471857002318 anticodon binding site; other site 471857002319 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 471857002320 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 471857002321 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 471857002322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857002323 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 471857002324 NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566 471857002325 Lsr2; Region: Lsr2; pfam11774 471857002326 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 471857002327 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 471857002328 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 471857002329 dimer interface [polypeptide binding]; other site 471857002330 active site 471857002331 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471857002332 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 471857002333 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 471857002334 dimer interface [polypeptide binding]; other site 471857002335 active site 471857002336 CoA binding pocket [chemical binding]; other site 471857002337 Acyl transferase domain; Region: Acyl_transf_1; cl08282 471857002338 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 471857002339 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 471857002340 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 471857002341 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 471857002342 dimer interface [polypeptide binding]; other site 471857002343 TPP-binding site [chemical binding]; other site 471857002344 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 471857002345 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 471857002346 dimer interface [polypeptide binding]; other site 471857002347 catalytic triad [active] 471857002348 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 471857002349 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 471857002350 Protein phosphatase 2C; Region: PP2C; pfam00481 471857002351 Active site [active] 471857002352 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 471857002353 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 471857002354 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 471857002355 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 471857002356 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 471857002357 generic binding surface I; other site 471857002358 generic binding surface II; other site 471857002359 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 471857002360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857002361 putative substrate translocation pore; other site 471857002362 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 471857002363 lipoyl synthase; Provisional; Region: PRK05481 471857002364 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 471857002365 FeS/SAM binding site; other site 471857002366 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857002367 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857002368 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 471857002369 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471857002370 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 471857002371 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 471857002372 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857002373 TIGR01777 family protein; Region: yfcH 471857002374 NAD(P) binding site [chemical binding]; other site 471857002375 active site 471857002376 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471857002377 E3 interaction surface; other site 471857002378 lipoyl attachment site [posttranslational modification]; other site 471857002379 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471857002380 E3 interaction surface; other site 471857002381 lipoyl attachment site [posttranslational modification]; other site 471857002382 e3 binding domain; Region: E3_binding; pfam02817 471857002383 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 471857002384 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 471857002385 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 471857002386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857002387 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857002388 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471857002389 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 471857002390 multifunctional aminopeptidase A; Provisional; Region: PRK00913 471857002391 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 471857002392 interface (dimer of trimers) [polypeptide binding]; other site 471857002393 Substrate-binding/catalytic site; other site 471857002394 Zn-binding sites [ion binding]; other site 471857002395 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 471857002396 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 471857002397 homodimer interface [polypeptide binding]; other site 471857002398 substrate-cofactor binding pocket; other site 471857002399 catalytic residue [active] 471857002400 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435 471857002401 putative dimer interface [polypeptide binding]; other site 471857002402 active site pocket [active] 471857002403 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 471857002404 substrate binding site [chemical binding]; other site 471857002405 dimer interface [polypeptide binding]; other site 471857002406 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 471857002407 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 471857002408 active site 471857002409 catalytic tetrad [active] 471857002410 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 471857002411 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 471857002412 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 471857002413 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 471857002414 active site 471857002415 dimer interface [polypeptide binding]; other site 471857002416 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 471857002417 Ligand Binding Site [chemical binding]; other site 471857002418 Molecular Tunnel; other site 471857002419 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 471857002420 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 471857002421 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 471857002422 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 471857002423 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 471857002424 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 471857002425 active site 471857002426 phosphorylation site [posttranslational modification] 471857002427 intermolecular recognition site; other site 471857002428 dimerization interface [polypeptide binding]; other site 471857002429 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 471857002430 Cytochrome c; Region: Cytochrom_C; cl11414 471857002431 Cytochrome c; Region: Cytochrom_C; cl11414 471857002432 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 471857002433 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 471857002434 iron-sulfur cluster [ion binding]; other site 471857002435 [2Fe-2S] cluster binding site [ion binding]; other site 471857002436 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 471857002437 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 471857002438 heme bH binding site [chemical binding]; other site 471857002439 intrachain domain interface; other site 471857002440 heme bL binding site [chemical binding]; other site 471857002441 interchain domain interface [polypeptide binding]; other site 471857002442 Qo binding site; other site 471857002443 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857002444 hypothetical protein; Validated; Region: PRK07883 471857002445 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 471857002446 active site 471857002447 substrate binding site [chemical binding]; other site 471857002448 catalytic site [active] 471857002449 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 471857002450 GIY-YIG motif/motif A; other site 471857002451 active site 471857002452 catalytic site [active] 471857002453 putative DNA binding site [nucleotide binding]; other site 471857002454 YacP-like NYN domain; Region: NYN_YacP; cl01491 471857002455 NlpC/P60 family; Region: NLPC_P60; cl11438 471857002456 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471857002457 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471857002458 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857002459 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 471857002460 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 471857002461 inhibitor-cofactor binding pocket; inhibition site 471857002462 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857002463 catalytic residue [active] 471857002464 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471857002465 biotin synthase; Validated; Region: PRK06256 471857002466 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 471857002467 FeS/SAM binding site; other site 471857002468 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 471857002469 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 471857002470 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 471857002471 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883 471857002472 nudix motif; other site 471857002473 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 471857002474 Quinolinate synthetase A protein; Region: NadA; cl00420 471857002475 L-aspartate oxidase; Provisional; Region: PRK07804 471857002476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857002477 domain; Region: Succ_DH_flav_C; pfam02910 471857002478 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 471857002479 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572 471857002480 dimerization interface [polypeptide binding]; other site 471857002481 active site 471857002482 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 471857002483 Predicted amidohydrolase [General function prediction only]; Region: COG0388 471857002484 putative active site [active] 471857002485 catalytic triad [active] 471857002486 putative dimer interface [polypeptide binding]; other site 471857002487 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 471857002488 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 471857002489 NAD binding site [chemical binding]; other site 471857002490 dimerization interface [polypeptide binding]; other site 471857002491 product binding site; other site 471857002492 substrate binding site [chemical binding]; other site 471857002493 zinc binding site [ion binding]; other site 471857002494 catalytic residues [active] 471857002495 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 471857002496 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471857002497 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857002498 homodimer interface [polypeptide binding]; other site 471857002499 catalytic residue [active] 471857002500 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 471857002501 putative active site pocket [active] 471857002502 4-fold oligomerization interface [polypeptide binding]; other site 471857002503 metal binding residues [ion binding]; metal-binding site 471857002504 3-fold/trimer interface [polypeptide binding]; other site 471857002505 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 471857002506 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857002507 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857002508 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 471857002509 DNA binding residues [nucleotide binding] 471857002510 dimer interface [polypeptide binding]; other site 471857002511 [2Fe-2S] cluster binding site [ion binding]; other site 471857002512 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 471857002513 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 471857002514 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 471857002515 tetramer interface [polypeptide binding]; other site 471857002516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857002517 catalytic residue [active] 471857002518 Domain of unknown function (DUF385); Region: DUF385; cl04387 471857002519 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471857002520 putative acyl-acceptor binding pocket; other site 471857002521 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 471857002522 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857002523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857002524 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471857002525 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 471857002526 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 471857002527 Walker A/P-loop; other site 471857002528 ATP binding site [chemical binding]; other site 471857002529 Q-loop/lid; other site 471857002530 ABC transporter signature motif; other site 471857002531 Walker B; other site 471857002532 D-loop; other site 471857002533 H-loop/switch region; other site 471857002534 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 471857002535 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 471857002536 TM-ABC transporter signature motif; other site 471857002537 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 471857002538 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471857002539 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857002540 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 471857002541 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 471857002542 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 471857002543 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 471857002544 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 471857002545 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 471857002546 metal binding site [ion binding]; metal-binding site 471857002547 ligand binding site [chemical binding]; other site 471857002548 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 471857002549 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 471857002550 Myo-inositol-1-phosphate synthase; Region: Inos-1-P_synth; cl00554 471857002551 UbiA prenyltransferase family; Region: UbiA; cl00337 471857002552 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471857002553 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 471857002554 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 471857002555 active site 471857002556 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471857002557 Sulfatase; Region: Sulfatase; cl10460 471857002558 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471857002559 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 471857002560 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471857002561 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 471857002562 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471857002563 anti sigma factor interaction site; other site 471857002564 regulatory phosphorylation site [posttranslational modification]; other site 471857002565 FOG: CBS domain [General function prediction only]; Region: COG0517 471857002566 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_9; cd04622 471857002567 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 471857002568 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 471857002569 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857002570 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 471857002571 putative active site [active] 471857002572 short chain dehydrogenase; Provisional; Region: PRK08219 471857002573 classical (c) SDRs; Region: SDR_c; cd05233 471857002574 NAD(P) binding site [chemical binding]; other site 471857002575 active site 471857002576 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 471857002577 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 471857002578 substrate binding site [chemical binding]; other site 471857002579 ATP binding site [chemical binding]; other site 471857002580 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471857002581 active site 471857002582 HIGH motif; other site 471857002583 nucleotide binding site [chemical binding]; other site 471857002584 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 471857002585 dimer interface [polypeptide binding]; other site 471857002586 active site 471857002587 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 471857002588 putative active site [active] 471857002589 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471857002590 active site 471857002591 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 471857002592 active site 471857002593 motif I; other site 471857002594 motif II; other site 471857002595 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 471857002596 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 471857002597 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471857002598 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 471857002599 NAD binding site [chemical binding]; other site 471857002600 putative substrate binding site 2 [chemical binding]; other site 471857002601 putative substrate binding site 1 [chemical binding]; other site 471857002602 active site 471857002603 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156 471857002604 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471857002605 active site 471857002606 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471857002607 active site 471857002608 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 471857002609 Clp amino terminal domain; Region: Clp_N; pfam02861 471857002610 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471857002611 Walker A motif; other site 471857002612 ATP binding site [chemical binding]; other site 471857002613 Walker B motif; other site 471857002614 arginine finger; other site 471857002615 UvrB/uvrC motif; Region: UVR; pfam02151 471857002616 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471857002617 Walker A motif; other site 471857002618 ATP binding site [chemical binding]; other site 471857002619 Walker B motif; other site 471857002620 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 471857002621 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 471857002622 UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449 471857002623 putative ADP-binding pocket [chemical binding]; other site 471857002624 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471857002625 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471857002626 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 471857002627 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471857002628 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 471857002629 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 471857002630 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 471857002631 putative substrate binding region [chemical binding]; other site 471857002632 FOG: CBS domain [General function prediction only]; Region: COG0517 471857002633 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC...; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 471857002634 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471857002635 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 471857002636 putative NAD(P) binding site [chemical binding]; other site 471857002637 active site 471857002638 putative substrate binding site [chemical binding]; other site 471857002639 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 471857002640 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 471857002641 dihydropteroate synthase; Region: DHPS; TIGR01496 471857002642 substrate binding pocket [chemical binding]; other site 471857002643 dimer interface [polypeptide binding]; other site 471857002644 inhibitor binding site; inhibition site 471857002645 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857002646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471857002647 active site 471857002648 phosphorylation site [posttranslational modification] 471857002649 intermolecular recognition site; other site 471857002650 dimerization interface [polypeptide binding]; other site 471857002651 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471857002652 DNA binding residues [nucleotide binding] 471857002653 dimerization interface [polypeptide binding]; other site 471857002654 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471857002655 Histidine kinase; Region: HisKA_3; pfam07730 471857002656 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471857002657 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 471857002658 Walker A/P-loop; other site 471857002659 ATP binding site [chemical binding]; other site 471857002660 Q-loop/lid; other site 471857002661 ABC transporter signature motif; other site 471857002662 Walker B; other site 471857002663 D-loop; other site 471857002664 H-loop/switch region; other site 471857002665 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 471857002666 Leucine carboxyl methyltransferase; Region: LCM; cl01306 471857002667 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 471857002668 nucleoside/Zn binding site; other site 471857002669 dimer interface [polypeptide binding]; other site 471857002670 catalytic motif [active] 471857002671 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 471857002672 nudix motif; other site 471857002673 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471857002674 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471857002675 DNA binding site [nucleotide binding] 471857002676 domain linker motif; other site 471857002677 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 471857002678 putative dimerization interface [polypeptide binding]; other site 471857002679 putative ligand binding site [chemical binding]; other site 471857002680 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 471857002681 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 471857002682 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471857002683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857002684 dimer interface [polypeptide binding]; other site 471857002685 conserved gate region; other site 471857002686 putative PBP binding loops; other site 471857002687 ABC-ATPase subunit interface; other site 471857002688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857002689 putative PBP binding loops; other site 471857002690 ABC-ATPase subunit interface; other site 471857002691 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471857002692 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471857002693 Peptidase family M23; Region: Peptidase_M23; pfam01551 471857002694 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471857002695 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471857002696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471857002697 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 471857002698 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cl00246 471857002699 FAD binding site [chemical binding]; other site 471857002700 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 471857002701 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 471857002702 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 471857002703 putative active site [active] 471857002704 putative substrate binding site [chemical binding]; other site 471857002705 putative cosubstrate binding site; other site 471857002706 catalytic site [active] 471857002707 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14192 471857002708 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 471857002709 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 471857002710 homodimer interface [polypeptide binding]; other site 471857002711 NADP binding site [chemical binding]; other site 471857002712 substrate binding site [chemical binding]; other site 471857002713 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 471857002714 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 471857002715 putative molybdopterin cofactor binding site [chemical binding]; other site 471857002716 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT)...; Region: MopB_CT_ydeP; cd02787 471857002717 putative molybdopterin cofactor binding site; other site 471857002718 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 471857002719 dihydropteroate synthase; Region: DHPS; TIGR01496 471857002720 substrate binding pocket [chemical binding]; other site 471857002721 dimer interface [polypeptide binding]; other site 471857002722 inhibitor binding site; inhibition site 471857002723 Copper resistance protein D; Region: CopD; cl00563 471857002724 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 471857002725 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 471857002726 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857002727 Walker A/P-loop; other site 471857002728 ATP binding site [chemical binding]; other site 471857002729 Q-loop/lid; other site 471857002730 ABC transporter signature motif; other site 471857002731 Walker B; other site 471857002732 D-loop; other site 471857002733 H-loop/switch region; other site 471857002734 ABC transporter; Region: ABC_tran_2; pfam12848 471857002735 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 471857002736 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 471857002737 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 471857002738 active site 471857002739 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454 471857002740 apolar tunnel; other site 471857002741 heme binding site [chemical binding]; other site 471857002742 dimerization interface [polypeptide binding]; other site 471857002743 Mechanosensitive ion channel; Region: MS_channel; pfam00924 471857002744 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 471857002745 active site 471857002746 Domain of unknown function (DUF477); Region: DUF477; cl01535 471857002747 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 471857002748 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 471857002749 Zn binding site [ion binding]; other site 471857002750 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 471857002751 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 471857002752 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471857002753 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471857002754 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 471857002755 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 471857002756 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 471857002757 putative DNA binding site [nucleotide binding]; other site 471857002758 catalytic residue [active] 471857002759 putative H2TH interface [polypeptide binding]; other site 471857002760 putative catalytic residues [active] 471857002761 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 471857002762 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 471857002763 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 471857002764 NlpC/P60 family; Region: NLPC_P60; cl11438 471857002765 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 471857002766 putative active site; other site 471857002767 putative triphosphate binding site [ion binding]; other site 471857002768 putative metal binding residues [ion binding]; other site 471857002769 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471857002770 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471857002771 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471857002772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471857002773 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 471857002774 Sodium:solute symporter family; Region: SSF; cl00456 471857002775 Protein of unknown function, DUF485; Region: DUF485; cl01231 471857002776 Sodium:solute symporter family; Region: SSF; cl00456 471857002777 Sodium:solute symporter family; Region: SSF; cl00456 471857002778 Sodium:solute symporter family; Region: SSF; cl00456 471857002779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471857002780 active site 471857002781 phosphorylation site [posttranslational modification] 471857002782 intermolecular recognition site; other site 471857002783 dimerization interface [polypeptide binding]; other site 471857002784 LytTr DNA-binding domain; Region: LytTR; cl04498 471857002785 Histidine kinase; Region: His_kinase; pfam06580 471857002786 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857002787 ATP binding site [chemical binding]; other site 471857002788 Mg2+ binding site [ion binding]; other site 471857002789 G-X-G motif; other site 471857002790 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 471857002791 trigger factor; Provisional; Region: tig; PRK01490 471857002792 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 471857002793 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 471857002794 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 471857002795 oligomer interface [polypeptide binding]; other site 471857002796 active site residues [active] 471857002797 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 471857002798 oligomer interface [polypeptide binding]; other site 471857002799 active site residues [active] 471857002800 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 471857002801 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 471857002802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471857002803 Walker A motif; other site 471857002804 ATP binding site [chemical binding]; other site 471857002805 Walker B motif; other site 471857002806 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 471857002807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471857002808 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 471857002809 Predicted esterase [General function prediction only]; Region: COG0627 471857002810 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 471857002811 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 471857002812 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 471857002813 HIGH motif; other site 471857002814 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 471857002815 active site 471857002816 KMSKS motif; other site 471857002817 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 471857002818 tRNA binding surface [nucleotide binding]; other site 471857002819 anticodon binding site; other site 471857002820 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 471857002821 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 471857002822 active site 471857002823 catalytic triad [active] 471857002824 oxyanion hole [active] 471857002825 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 471857002826 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 471857002827 Walker A/P-loop; other site 471857002828 ATP binding site [chemical binding]; other site 471857002829 Q-loop/lid; other site 471857002830 ABC transporter signature motif; other site 471857002831 Walker B; other site 471857002832 D-loop; other site 471857002833 H-loop/switch region; other site 471857002834 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 471857002835 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 471857002836 TM-ABC transporter signature motif; other site 471857002837 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 471857002838 TM-ABC transporter signature motif; other site 471857002839 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 471857002840 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 471857002841 putative ligand binding site [chemical binding]; other site 471857002842 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471857002843 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 471857002844 DNA interaction; other site 471857002845 Metal-binding active site; metal-binding site 471857002846 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 471857002847 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 471857002848 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 471857002849 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 471857002850 metal binding site [ion binding]; metal-binding site 471857002851 ligand binding site [chemical binding]; other site 471857002852 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857002853 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471857002854 putative substrate translocation pore; other site 471857002855 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471857002856 S-adenosylmethionine binding site [chemical binding]; other site 471857002857 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 471857002858 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471857002859 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471857002860 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 471857002861 active site 471857002862 multimer interface [polypeptide binding]; other site 471857002863 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 471857002864 Asp-box motif; other site 471857002865 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471857002866 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 471857002867 active site 471857002868 catalytic residues [active] 471857002869 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 471857002870 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 471857002871 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 471857002872 homodimer interface [polypeptide binding]; other site 471857002873 oligonucleotide binding site [chemical binding]; other site 471857002874 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 471857002875 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 471857002876 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 471857002877 GTPase CgtA; Reviewed; Region: obgE; PRK12296 471857002878 GTP1/OBG; Region: GTP1_OBG; pfam01018 471857002879 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 471857002880 G1 box; other site 471857002881 GTP/Mg2+ binding site [chemical binding]; other site 471857002882 Switch I region; other site 471857002883 G2 box; other site 471857002884 G3 box; other site 471857002885 Switch II region; other site 471857002886 G4 box; other site 471857002887 G5 box; other site 471857002888 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 471857002889 gamma-glutamyl kinase; Provisional; Region: PRK05429 471857002890 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 471857002891 nucleotide binding site [chemical binding]; other site 471857002892 homotetrameric interface [polypeptide binding]; other site 471857002893 putative phosphate binding site [ion binding]; other site 471857002894 putative allosteric binding site; other site 471857002895 PUA domain; Region: PUA; cl00607 471857002896 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 471857002897 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 471857002898 active site 471857002899 (T/H)XGH motif; other site 471857002900 Domain of unknown function DUF143; Region: DUF143; cl00519 471857002901 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471857002902 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 471857002903 catalytic core [active] 471857002904 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 471857002905 active site 471857002906 catalytic triad [active] 471857002907 oxyanion hole [active] 471857002908 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 471857002909 SLBB domain; Region: SLBB; pfam10531 471857002910 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 471857002911 Competence protein; Region: Competence; cl00471 471857002912 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471857002913 threonine synthase; Validated; Region: PRK07591 471857002914 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563 471857002915 homodimer interface [polypeptide binding]; other site 471857002916 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857002917 catalytic residue [active] 471857002918 hypothetical protein; Reviewed; Region: PRK07914 471857002919 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 471857002920 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 471857002921 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471857002922 active site 471857002923 metal binding site [ion binding]; metal-binding site 471857002924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471857002925 GTP-binding protein LepA; Provisional; Region: PRK05433 471857002926 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 471857002927 G1 box; other site 471857002928 putative GEF interaction site [polypeptide binding]; other site 471857002929 GTP/Mg2+ binding site [chemical binding]; other site 471857002930 Switch I region; other site 471857002931 G2 box; other site 471857002932 G3 box; other site 471857002933 Switch II region; other site 471857002934 G4 box; other site 471857002935 G5 box; other site 471857002936 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 471857002937 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 471857002938 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 471857002939 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 471857002940 Nitronate monooxygenase; Region: NMO; pfam03060 471857002941 FMN binding site [chemical binding]; other site 471857002942 substrate binding site [chemical binding]; other site 471857002943 putative catalytic residue [active] 471857002944 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471857002945 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 471857002946 NAD(P) binding site [chemical binding]; other site 471857002947 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 471857002948 putative RNAase interaction site [polypeptide binding]; other site 471857002949 enoyl-CoA hydratase; Provisional; Region: PRK07827 471857002950 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471857002951 substrate binding site [chemical binding]; other site 471857002952 oxyanion hole (OAH) forming residues; other site 471857002953 trimer interface [polypeptide binding]; other site 471857002954 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 471857002955 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 471857002956 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 471857002957 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_N; cd03416 471857002958 putative active site [active] 471857002959 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_C; cd03414 471857002960 putative active site [active] 471857002961 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 471857002962 CysN_ATPS subfamily. CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes. ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate. CysD, which...; Region: CysN_ATPS; cd04166 471857002963 CysD dimerization site [polypeptide binding]; other site 471857002964 G1 box; other site 471857002965 putative GEF interaction site [polypeptide binding]; other site 471857002966 GTP/Mg2+ binding site [chemical binding]; other site 471857002967 Switch I region; other site 471857002968 G2 box; other site 471857002969 G3 box; other site 471857002970 Switch II region; other site 471857002971 G4 box; other site 471857002972 G5 box; other site 471857002973 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NodQ_II; cd03695 471857002974 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NoDQ_III; cd04095 471857002975 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 471857002976 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 471857002977 Active Sites [active] 471857002978 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 471857002979 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 471857002980 Active Sites [active] 471857002981 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 471857002982 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 471857002983 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 471857002984 coproporphyrinogen III oxidase; Validated; Region: PRK05628 471857002985 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 471857002986 HemN C-terminal region; Region: HemN_C; pfam06969 471857002987 Uncharacterized conserved protein [Function unknown]; Region: COG3268 471857002988 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857002989 Transcription factor WhiB; Region: Whib; pfam02467 471857002990 Domain of unknown function DUF; Region: DUF202; cl09954 471857002991 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471857002992 anti sigma factor interaction site; other site 471857002993 regulatory phosphorylation site [posttranslational modification]; other site 471857002994 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 471857002995 Fe-S cluster binding site [ion binding]; other site 471857002996 active site 471857002997 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 471857002998 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 471857002999 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 471857003000 NAD binding site [chemical binding]; other site 471857003001 catalytic Zn binding site [ion binding]; other site 471857003002 structural Zn binding site [ion binding]; other site 471857003003 Glycerate kinase family; Region: Gly_kinase; cl00841 471857003004 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857003005 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 471857003006 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 471857003007 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 471857003008 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471857003009 dimer interface [polypeptide binding]; other site 471857003010 active site 471857003011 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 471857003012 multimer interface [polypeptide binding]; other site 471857003013 heterodimer interface [polypeptide binding]; other site 471857003014 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 471857003015 active site 471857003016 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 471857003017 heterodimer interface [polypeptide binding]; other site 471857003018 active site 471857003019 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 471857003020 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 471857003021 tetramer interface [polypeptide binding]; other site 471857003022 active site 471857003023 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 471857003024 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471857003025 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 471857003026 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 471857003027 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857003028 Bacterial transcriptional regulator; Region: IclR; pfam01614 471857003029 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 471857003030 metal binding site [ion binding]; metal-binding site 471857003031 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471857003032 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 471857003033 Walker A motif; other site 471857003034 ATP binding site [chemical binding]; other site 471857003035 Walker B motif; other site 471857003036 arginine finger; other site 471857003037 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 471857003038 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471857003039 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 471857003040 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 471857003041 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 471857003042 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471857003043 catalytic loop [active] 471857003044 iron binding site [ion binding]; other site 471857003045 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 471857003046 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 471857003047 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 471857003048 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 471857003049 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 471857003050 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 471857003051 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 471857003052 putative hydrophobic ligand binding site [chemical binding]; other site 471857003053 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857003054 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 471857003055 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan...; Region: Sortase_E; cd05829 471857003056 active site 471857003057 putative catalytic site [active] 471857003058 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 471857003059 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471857003060 Walker A/P-loop; other site 471857003061 ATP binding site [chemical binding]; other site 471857003062 Q-loop/lid; other site 471857003063 ABC transporter signature motif; other site 471857003064 Walker B; other site 471857003065 D-loop; other site 471857003066 H-loop/switch region; other site 471857003067 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471857003068 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 471857003069 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471857003070 Walker A/P-loop; other site 471857003071 ATP binding site [chemical binding]; other site 471857003072 Q-loop/lid; other site 471857003073 ABC transporter signature motif; other site 471857003074 Walker B; other site 471857003075 D-loop; other site 471857003076 H-loop/switch region; other site 471857003077 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471857003078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857003079 putative PBP binding loops; other site 471857003080 dimer interface [polypeptide binding]; other site 471857003081 ABC-ATPase subunit interface; other site 471857003082 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471857003083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857003084 dimer interface [polypeptide binding]; other site 471857003085 conserved gate region; other site 471857003086 putative PBP binding loops; other site 471857003087 ABC-ATPase subunit interface; other site 471857003088 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471857003089 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471857003090 DNA binding site [nucleotide binding] 471857003091 domain linker motif; other site 471857003092 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471857003093 dimerization interface [polypeptide binding]; other site 471857003094 ligand binding site [chemical binding]; other site 471857003095 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 471857003096 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471857003097 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 471857003098 putative active site [active] 471857003099 catalytic site [active] 471857003100 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 471857003101 putative active site [active] 471857003102 catalytic site [active] 471857003103 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471857003104 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 471857003105 catalytic core [active] 471857003106 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 471857003107 N- and C-terminal domain interface [polypeptide binding]; other site 471857003108 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 471857003109 active site 471857003110 MgATP binding site [chemical binding]; other site 471857003111 catalytic site [active] 471857003112 metal binding site [ion binding]; metal-binding site 471857003113 carbohydrate binding site [chemical binding]; other site 471857003114 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 471857003115 L-xylulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 471857003116 putative N- and C-terminal domain interface [polypeptide binding]; other site 471857003117 putative active site [active] 471857003118 putative MgATP binding site [chemical binding]; other site 471857003119 catalytic site [active] 471857003120 metal binding site [ion binding]; metal-binding site 471857003121 putative xylulose binding site [chemical binding]; other site 471857003122 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 471857003123 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857003124 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 471857003125 glycine dehydrogenase; Provisional; Region: PRK05367 471857003126 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471857003127 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471857003128 catalytic residue [active] 471857003129 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 471857003130 tetramer interface [polypeptide binding]; other site 471857003131 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857003132 catalytic residue [active] 471857003133 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 471857003134 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 471857003135 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 471857003136 lipoyl attachment site [posttranslational modification]; other site 471857003137 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 471857003138 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 471857003139 dimer interface [polypeptide binding]; other site 471857003140 glycine-pyridoxal phosphate binding site [chemical binding]; other site 471857003141 active site 471857003142 folate binding site [chemical binding]; other site 471857003143 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 471857003144 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471857003145 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 471857003146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857003147 putative substrate translocation pore; other site 471857003148 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 471857003149 DNA binding residues [nucleotide binding] 471857003150 drug binding residues [chemical binding]; other site 471857003151 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cl02940 471857003152 beta-clamp/clamp loader binding surface; other site 471857003153 beta-clamp/translesion DNA polymerase binding surface; other site 471857003154 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 471857003155 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 471857003156 putative active site [active] 471857003157 putative substrate binding site [chemical binding]; other site 471857003158 putative FMN binding site [chemical binding]; other site 471857003159 putative catalytic residues [active] 471857003160 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 471857003161 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471857003162 ATP binding site [chemical binding]; other site 471857003163 putative Mg++ binding site [ion binding]; other site 471857003164 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857003165 Helicase associated domain (HA2); Region: HA2; cl04503 471857003166 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 471857003167 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 471857003168 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 471857003169 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 471857003170 active site 471857003171 DNA binding site [nucleotide binding] 471857003172 catalytic site [active] 471857003173 acyl-CoA synthetase; Validated; Region: PRK07788 471857003174 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857003175 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 471857003176 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 471857003177 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 471857003178 calcium binding site 2 [ion binding]; other site 471857003179 active site 471857003180 catalytic triad [active] 471857003181 calcium binding site 1 [ion binding]; other site 471857003182 short chain dehydrogenase; Provisional; Region: PRK08251 471857003183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857003184 NAD(P) binding site [chemical binding]; other site 471857003185 active site 471857003186 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 471857003187 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471857003188 catalytic core [active] 471857003189 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 471857003190 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857003191 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 471857003192 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 471857003193 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 471857003194 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 471857003195 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 471857003196 FAD binding pocket [chemical binding]; other site 471857003197 FAD binding motif [chemical binding]; other site 471857003198 phosphate binding motif [ion binding]; other site 471857003199 NAD binding pocket [chemical binding]; other site 471857003200 Subtilisin inhibitor-like; Region: SSI; cl11594 471857003201 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 471857003202 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857003203 HrcA protein C terminal domain; Region: HrcA; pfam01628 471857003204 chaperone protein DnaJ; Provisional; Region: PRK14278 471857003205 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 471857003206 HSP70 interaction site [polypeptide binding]; other site 471857003207 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 471857003208 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 471857003209 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 471857003210 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 471857003211 nucleotide binding site/active site [active] 471857003212 HIT family signature motif; other site 471857003213 catalytic residue [active] 471857003214 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 471857003215 PhoH-like protein; Region: PhoH; cl12134 471857003216 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 471857003217 Domain of unknown function DUF21; Region: DUF21; pfam01595 471857003218 FOG: CBS domain [General function prediction only]; Region: COG0517 471857003219 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471857003220 Transporter associated domain; Region: CorC_HlyC; cl08393 471857003221 GTPase Era; Reviewed; Region: era; PRK00089 471857003222 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 471857003223 G1 box; other site 471857003224 GTP/Mg2+ binding site [chemical binding]; other site 471857003225 Switch I region; other site 471857003226 G2 box; other site 471857003227 Switch II region; other site 471857003228 G3 box; other site 471857003229 G4 box; other site 471857003230 G5 box; other site 471857003231 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 471857003232 RDD family; Region: RDD; cl00746 471857003233 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 471857003234 Recombination protein O N terminal; Region: RecO_N; pfam11967 471857003235 Recombination protein O C terminal; Region: RecO_C; pfam02565 471857003236 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 471857003237 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 471857003238 catalytic residue [active] 471857003239 putative FPP diphosphate binding site; other site 471857003240 putative FPP binding hydrophobic cleft; other site 471857003241 dimer interface [polypeptide binding]; other site 471857003242 putative IPP diphosphate binding site; other site 471857003243 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 471857003244 metal binding site 2 [ion binding]; metal-binding site 471857003245 putative DNA binding helix; other site 471857003246 metal binding site 1 [ion binding]; metal-binding site 471857003247 dimer interface [polypeptide binding]; other site 471857003248 structural Zn2+ binding site [ion binding]; other site 471857003249 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471857003250 dimerization interface [polypeptide binding]; other site 471857003251 putative DNA binding site [nucleotide binding]; other site 471857003252 putative Zn2+ binding site [ion binding]; other site 471857003253 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan...; Region: Sortase_E; cd05829 471857003254 active site 471857003255 putative catalytic site [active] 471857003256 glycyl-tRNA synthetase; Provisional; Region: PRK04173 471857003257 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 471857003258 motif 1; other site 471857003259 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the...; Region: GlyRS-like_core; cd00774 471857003260 active site 471857003261 motif 2; other site 471857003262 motif 3; other site 471857003263 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 471857003264 anticodon binding site; other site 471857003265 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 471857003266 putative active site [active] 471857003267 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 471857003268 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 471857003269 homodimer interface [polypeptide binding]; other site 471857003270 substrate-cofactor binding pocket; other site 471857003271 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857003272 catalytic residue [active] 471857003273 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471857003274 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 471857003275 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471857003276 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471857003277 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471857003278 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 471857003279 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which...; Region: SERPIN; cd00172 471857003280 reactive center loop; other site 471857003281 DNA primase; Validated; Region: dnaG; PRK05667 471857003282 CHC2 zinc finger; Region: zf-CHC2; cl02597 471857003283 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 471857003284 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 471857003285 active site 471857003286 metal binding site [ion binding]; metal-binding site 471857003287 interdomain interaction site; other site 471857003288 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 471857003289 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 471857003290 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 471857003291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471857003292 S-adenosylmethionine binding site [chemical binding]; other site 471857003293 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 471857003294 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857003295 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 471857003296 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 471857003297 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cl09719 471857003298 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 471857003299 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 471857003300 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 471857003301 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cl08497 471857003302 BCCT family transporter; Region: BCCT; cl00569 471857003303 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 471857003304 active site 471857003305 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 471857003306 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471857003307 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857003308 DNA-binding site [nucleotide binding]; DNA binding site 471857003309 UTRA domain; Region: UTRA; cl01230 471857003310 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 471857003311 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 471857003312 cyanate hydratase; Validated; Region: PRK02866 471857003313 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 471857003314 oligomer interface [polypeptide binding]; other site 471857003315 active site 471857003316 hydroperoxidase II; Provisional; Region: katE; PRK11249 471857003317 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 471857003318 heme binding pocket [chemical binding]; other site 471857003319 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 471857003320 domain interactions; other site 471857003321 Penicillin amidase; Region: Penicil_amidase; pfam01804 471857003322 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 471857003323 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 471857003324 active site 471857003325 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 471857003326 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 471857003327 putative hydrophobic ligand binding site [chemical binding]; other site 471857003328 NAD-dependent deacetylase; Provisional; Region: PRK05333 471857003329 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195 471857003330 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 471857003331 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857003332 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 471857003333 TPP-binding site [chemical binding]; other site 471857003334 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 471857003335 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471857003336 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471857003337 S-adenosylmethionine binding site [chemical binding]; other site 471857003338 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 471857003339 dimer interface [polypeptide binding]; other site 471857003340 ADP-ribose binding site [chemical binding]; other site 471857003341 active site 471857003342 nudix motif; other site 471857003343 metal binding site [ion binding]; metal-binding site 471857003344 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471857003345 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471857003346 Sodium:solute symporter family; Region: SSF; cl00456 471857003347 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 471857003348 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 471857003349 dimer interface [polypeptide binding]; other site 471857003350 active site 471857003351 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 471857003352 domain; Region: Glyco_hydro_2; pfam00703 471857003353 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 471857003354 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 471857003355 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 471857003356 galactokinase; Provisional; Region: PRK03817 471857003357 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 471857003358 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 471857003359 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 471857003360 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857003361 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 471857003362 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 471857003363 catalytic residues [active] 471857003364 dimer interface [polypeptide binding]; other site 471857003365 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and...; Region: XynE_like; cd01830 471857003366 active site 471857003367 catalytic triad [active] 471857003368 oxyanion hole [active] 471857003369 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 471857003370 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 471857003371 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 471857003372 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 471857003373 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 471857003374 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 471857003375 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471857003376 ChaB; Region: ChaB; cl01887 471857003377 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 471857003378 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 471857003379 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 471857003380 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857003381 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471857003382 DNA binding residues [nucleotide binding] 471857003383 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471857003384 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 471857003385 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 471857003386 putative active site [active] 471857003387 putative metal binding site [ion binding]; other site 471857003388 Bacterial membrane flanked domain; Region: DUF304; cl01348 471857003389 Bacterial membrane flanked domain; Region: DUF304; cl01348 471857003390 Predicted membrane protein [Function unknown]; Region: COG3428 471857003391 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471857003392 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471857003393 catalytic residue [active] 471857003394 ribosome maturation protein RimP; Reviewed; Region: PRK00092 471857003395 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 471857003396 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 471857003397 Sm1 motif; other site 471857003398 D3 - B interaction site; other site 471857003399 D1 - D2 interaction site; other site 471857003400 Hfq - Hfq interaction site; other site 471857003401 RNA binding pocket [nucleotide binding]; other site 471857003402 Sm2 motif; other site 471857003403 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 471857003404 NusA N-terminal domain; Region: NusA_N; pfam08529 471857003405 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 471857003406 RNA binding site [nucleotide binding]; other site 471857003407 homodimer interface [polypeptide binding]; other site 471857003408 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 471857003409 G-X-X-G motif; other site 471857003410 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 471857003411 putative RNA binding cleft [nucleotide binding]; other site 471857003412 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 471857003413 translation initiation factor IF-2; Region: IF-2; TIGR00487 471857003414 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 471857003415 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 471857003416 G1 box; other site 471857003417 putative GEF interaction site [polypeptide binding]; other site 471857003418 GTP/Mg2+ binding site [chemical binding]; other site 471857003419 Switch I region; other site 471857003420 G2 box; other site 471857003421 G3 box; other site 471857003422 Switch II region; other site 471857003423 G4 box; other site 471857003424 G5 box; other site 471857003425 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 471857003426 Translation-initiation factor 2; Region: IF-2; pfam11987 471857003427 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 471857003428 Protein of unknown function (DUF503); Region: DUF503; cl00669 471857003429 Ribosome-binding factor A; Region: RBFA; cl00542 471857003430 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857003431 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 471857003432 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 471857003433 MatE; Region: MatE; cl10513 471857003434 MatE; Region: MatE; cl10513 471857003435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857003436 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471857003437 putative substrate translocation pore; other site 471857003438 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 471857003439 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 471857003440 RNA binding site [nucleotide binding]; other site 471857003441 active site 471857003442 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 471857003443 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 471857003444 active site 471857003445 Riboflavin kinase; Region: Flavokinase; cl03312 471857003446 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471857003447 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 471857003448 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 471857003449 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 471857003450 16S/18S rRNA binding site [nucleotide binding]; other site 471857003451 S13e-L30e interaction site [polypeptide binding]; other site 471857003452 25S rRNA binding site [nucleotide binding]; other site 471857003453 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 471857003454 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 471857003455 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 471857003456 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 471857003457 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 471857003458 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 471857003459 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 471857003460 putative nucleic acid binding region [nucleotide binding]; other site 471857003461 G-X-X-G motif; other site 471857003462 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 471857003463 RNA binding site [nucleotide binding]; other site 471857003464 domain interface; other site 471857003465 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 471857003466 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 471857003467 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471857003468 dihydrodipicolinate reductase; Provisional; Region: PRK00048 471857003469 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857003470 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 471857003471 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 471857003472 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 471857003473 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 471857003474 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 471857003475 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 471857003476 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 471857003477 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 471857003478 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 471857003479 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 471857003480 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 471857003481 cytidylate kinase; Provisional; Region: cmk; PRK00023 471857003482 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 471857003483 CMP-binding site; other site 471857003484 The sites determining sugar specificity; other site 471857003485 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471857003486 putative acyl-acceptor binding pocket; other site 471857003487 GTP-binding protein Der; Reviewed; Region: PRK03003 471857003488 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 471857003489 G1 box; other site 471857003490 GTP/Mg2+ binding site [chemical binding]; other site 471857003491 Switch I region; other site 471857003492 G2 box; other site 471857003493 Switch II region; other site 471857003494 G3 box; other site 471857003495 G4 box; other site 471857003496 G5 box; other site 471857003497 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 471857003498 G1 box; other site 471857003499 GTP/Mg2+ binding site [chemical binding]; other site 471857003500 Switch I region; other site 471857003501 G2 box; other site 471857003502 G3 box; other site 471857003503 Switch II region; other site 471857003504 G4 box; other site 471857003505 G5 box; other site 471857003506 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 471857003507 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471857003508 PAC2 family; Region: PAC2; cl00847 471857003509 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 471857003510 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 471857003511 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 471857003512 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 471857003513 active site 471857003514 dimer interface [polypeptide binding]; other site 471857003515 motif 1; other site 471857003516 motif 2; other site 471857003517 motif 3; other site 471857003518 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 471857003519 anticodon binding site; other site 471857003520 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 471857003521 nucleotide binding site/active site [active] 471857003522 HIT family signature motif; other site 471857003523 catalytic residue [active] 471857003524 YceI-like domain; Region: YceI; cl01001 471857003525 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471857003526 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857003527 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 471857003528 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471857003529 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 471857003530 putative acyl-acceptor binding pocket; other site 471857003531 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471857003532 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471857003533 pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180 471857003534 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 471857003535 active site 471857003536 multimer interface [polypeptide binding]; other site 471857003537 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857003538 non-specific DNA binding site [nucleotide binding]; other site 471857003539 salt bridge; other site 471857003540 sequence-specific DNA binding site [nucleotide binding]; other site 471857003541 AzlC protein; Region: AzlC; cl00570 471857003542 Domain of unknown function DUF28; Region: DUF28; cl00361 471857003543 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 471857003544 active site 471857003545 putative DNA-binding cleft [nucleotide binding]; other site 471857003546 dimer interface [polypeptide binding]; other site 471857003547 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 471857003548 RuvA N terminal domain; Region: RuvA_N; pfam01330 471857003549 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 471857003550 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 471857003551 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471857003552 Walker A motif; other site 471857003553 ATP binding site [chemical binding]; other site 471857003554 Walker B motif; other site 471857003555 arginine finger; other site 471857003556 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 471857003557 Preprotein translocase subunit; Region: YajC; cl00806 471857003558 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 471857003559 Protein export membrane protein; Region: SecD_SecF; cl14618 471857003560 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 471857003561 Protein export membrane protein; Region: SecD_SecF; cl14618 471857003562 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 471857003563 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 471857003564 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 471857003565 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 471857003566 synthetase active site [active] 471857003567 NTP binding site [chemical binding]; other site 471857003568 metal binding site [ion binding]; metal-binding site 471857003569 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 471857003570 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 471857003571 enoyl-CoA hydratase; Provisional; Region: PRK06127 471857003572 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471857003573 substrate binding site [chemical binding]; other site 471857003574 oxyanion hole (OAH) forming residues; other site 471857003575 trimer interface [polypeptide binding]; other site 471857003576 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 471857003577 homodimer interface [polypeptide binding]; other site 471857003578 substrate-cofactor binding pocket; other site 471857003579 Aminotransferase class IV; Region: Aminotran_4; pfam01063 471857003580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857003581 catalytic residue [active] 471857003582 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 471857003583 active site 471857003584 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471857003585 YibE/F-like protein; Region: YibE_F; cl02259 471857003586 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 471857003587 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 471857003588 PYR/PP interface [polypeptide binding]; other site 471857003589 dimer interface [polypeptide binding]; other site 471857003590 TPP binding site [chemical binding]; other site 471857003591 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 471857003592 TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of benzoylformate to benzaldehyde and carbon dioxide. This...; Region: TPP_BFDC; cd02002 471857003593 TPP-binding site [chemical binding]; other site 471857003594 dimer interface [polypeptide binding]; other site 471857003595 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471857003596 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857003597 Bacterial transcriptional regulator; Region: IclR; pfam01614 471857003598 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 471857003599 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 471857003600 dimer interface [polypeptide binding]; other site 471857003601 anticodon binding site; other site 471857003602 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 471857003603 homodimer interface [polypeptide binding]; other site 471857003604 motif 1; other site 471857003605 active site 471857003606 motif 2; other site 471857003607 GAD domain; Region: GAD; pfam02938 471857003608 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 471857003609 motif 3; other site 471857003610 recombination factor protein RarA; Reviewed; Region: PRK13342 471857003611 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471857003612 Walker A motif; other site 471857003613 ATP binding site [chemical binding]; other site 471857003614 Walker B motif; other site 471857003615 arginine finger; other site 471857003616 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 471857003617 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 471857003618 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 471857003619 motif 1; other site 471857003620 active site 471857003621 motif 2; other site 471857003622 motif 3; other site 471857003623 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 471857003624 DHHA1 domain; Region: DHHA1; pfam02272 471857003625 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 471857003626 YceG-like family; Region: YceG; pfam02618 471857003627 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 471857003628 dimerization interface [polypeptide binding]; other site 471857003629 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 471857003630 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 471857003631 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 471857003632 shikimate binding site; other site 471857003633 NAD(P) binding site [chemical binding]; other site 471857003634 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 471857003635 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857003636 Beta-lactamase; Region: Beta-lactamase; cl01009 471857003637 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 471857003638 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 471857003639 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 471857003640 dimerization domain swap beta strand [polypeptide binding]; other site 471857003641 regulatory protein interface [polypeptide binding]; other site 471857003642 active site 471857003643 regulatory phosphorylation site [posttranslational modification]; other site 471857003644 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 471857003645 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471857003646 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857003647 DNA-binding site [nucleotide binding]; DNA binding site 471857003648 UTRA domain; Region: UTRA; cl01230 471857003649 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 471857003650 active site turn [active] 471857003651 phosphorylation site [posttranslational modification] 471857003652 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 471857003653 HPr interaction site; other site 471857003654 glycerol kinase (GK) interaction site [polypeptide binding]; other site 471857003655 active site 471857003656 phosphorylation site [posttranslational modification] 471857003657 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 471857003658 iron-sulfur cluster [ion binding]; other site 471857003659 [2Fe-2S] cluster binding site [ion binding]; other site 471857003660 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 471857003661 Tetramer interface [polypeptide binding]; other site 471857003662 Active site [active] 471857003663 FMN-binding site [chemical binding]; other site 471857003664 shikimate kinase; Reviewed; Region: aroK; PRK00131 471857003665 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 471857003666 ADP binding site [chemical binding]; other site 471857003667 magnesium binding site [ion binding]; other site 471857003668 putative shikimate binding site; other site 471857003669 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 471857003670 active site 471857003671 dimer interface [polypeptide binding]; other site 471857003672 metal binding site [ion binding]; metal-binding site 471857003673 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 471857003674 trimer interface [polypeptide binding]; other site 471857003675 active site 471857003676 dimer interface [polypeptide binding]; other site 471857003677 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 471857003678 active site 471857003679 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 471857003680 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 471857003681 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 471857003682 active site 471857003683 elongation factor P; Validated; Region: PRK00529 471857003684 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 471857003685 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 471857003686 RNA binding site [nucleotide binding]; other site 471857003687 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 471857003688 RNA binding site [nucleotide binding]; other site 471857003689 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 471857003690 putative RNA binding site [nucleotide binding]; other site 471857003691 Predicted transcriptional regulator [Transcription]; Region: COG1395 471857003692 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471857003693 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 471857003694 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 471857003695 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 471857003696 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857003697 dihydroorotase; Validated; Region: pyrC; PRK09357 471857003698 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 471857003699 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317 471857003700 active site 471857003701 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 471857003702 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 471857003703 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 471857003704 catalytic site [active] 471857003705 subunit interface [polypeptide binding]; other site 471857003706 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 471857003707 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471857003708 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 471857003709 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 471857003710 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471857003711 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 471857003712 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 471857003713 IMP binding site; other site 471857003714 dimer interface [polypeptide binding]; other site 471857003715 interdomain contacts; other site 471857003716 partial ornithine binding site; other site 471857003717 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 471857003718 active site 471857003719 dimer interface [polypeptide binding]; other site 471857003720 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 471857003721 catalytic site [active] 471857003722 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 471857003723 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 471857003724 Flavoprotein; Region: Flavoprotein; cl08021 471857003725 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 471857003726 S-adenosylmethionine synthetase; Validated; Region: PRK05250 471857003727 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 471857003728 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 471857003729 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 471857003730 primosome assembly protein PriA; Provisional; Region: PRK14873 471857003731 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 471857003732 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 471857003733 putative active site [active] 471857003734 substrate binding site [chemical binding]; other site 471857003735 putative cosubstrate binding site; other site 471857003736 catalytic site [active] 471857003737 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 471857003738 substrate binding site [chemical binding]; other site 471857003739 16S rRNA methyltransferase B; Provisional; Region: PRK14902 471857003740 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 471857003741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471857003742 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 471857003743 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 471857003744 substrate binding site [chemical binding]; other site 471857003745 hexamer interface [polypeptide binding]; other site 471857003746 metal binding site [ion binding]; metal-binding site 471857003747 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 471857003748 catalytic motif [active] 471857003749 Zn binding site [ion binding]; other site 471857003750 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 471857003751 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 471857003752 Lumazine binding domain; Region: Lum_binding; pfam00677 471857003753 Lumazine binding domain; Region: Lum_binding; pfam00677 471857003754 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 471857003755 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 471857003756 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 471857003757 dimerization interface [polypeptide binding]; other site 471857003758 active site 471857003759 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 471857003760 homopentamer interface [polypeptide binding]; other site 471857003761 active site 471857003762 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 471857003763 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 471857003764 EamA-like transporter family; Region: EamA; cl01037 471857003765 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 471857003766 putative phosphate binding site [ion binding]; other site 471857003767 putative catalytic site [active] 471857003768 active site 471857003769 metal binding site A [ion binding]; metal-binding site 471857003770 DNA binding site [nucleotide binding] 471857003771 putative AP binding site [nucleotide binding]; other site 471857003772 putative metal binding site B [ion binding]; other site 471857003773 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 471857003774 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 471857003775 GIY-YIG motif/motif A; other site 471857003776 active site 471857003777 catalytic site [active] 471857003778 putative DNA binding site [nucleotide binding]; other site 471857003779 metal binding site [ion binding]; metal-binding site 471857003780 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 471857003781 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857003782 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 471857003783 dimer interface [polypeptide binding]; other site 471857003784 phosphate binding site [ion binding]; other site 471857003785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 471857003786 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 471857003787 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471857003788 active site 471857003789 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 471857003790 putative hydrophobic ligand binding site [chemical binding]; other site 471857003791 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 471857003792 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 471857003793 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 471857003794 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 471857003795 substrate binding site [chemical binding]; other site 471857003796 hinge regions; other site 471857003797 ADP binding site [chemical binding]; other site 471857003798 catalytic site [active] 471857003799 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 471857003800 substrate binding site [chemical binding]; other site 471857003801 dimer interface [polypeptide binding]; other site 471857003802 catalytic triad [active] 471857003803 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471857003804 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 471857003805 putative active site [active] 471857003806 opcA protein; Region: OpcA; TIGR00534 471857003807 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 471857003808 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 471857003809 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 471857003810 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 471857003811 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 471857003812 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 471857003813 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 471857003814 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 471857003815 putative active site [active] 471857003816 transaldolase; Provisional; Region: PRK03903 471857003817 catalytic residue [active] 471857003818 transketolase; Reviewed; Region: PRK05899 471857003819 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 471857003820 TPP-binding site [chemical binding]; other site 471857003821 dimer interface [polypeptide binding]; other site 471857003822 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 471857003823 PYR/PP interface [polypeptide binding]; other site 471857003824 dimer interface [polypeptide binding]; other site 471857003825 TPP binding site [chemical binding]; other site 471857003826 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471857003827 UbiA prenyltransferase family; Region: UbiA; cl00337 471857003828 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 471857003829 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 471857003830 UvrD/REP helicase; Region: UvrD-helicase; cl14126 471857003831 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 471857003832 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 471857003833 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 471857003834 NADP binding site [chemical binding]; other site 471857003835 dimer interface [polypeptide binding]; other site 471857003836 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 471857003837 active site 471857003838 Fatty acid desaturase; Region: FA_desaturase; pfam00487 471857003839 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 471857003840 Di-iron ligands [ion binding]; other site 471857003841 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 471857003842 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 471857003843 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471857003844 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471857003845 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency...; Region: ABC_subfamily_A; cd03263 471857003846 Walker A/P-loop; other site 471857003847 ATP binding site [chemical binding]; other site 471857003848 Q-loop/lid; other site 471857003849 ABC transporter signature motif; other site 471857003850 Walker B; other site 471857003851 D-loop; other site 471857003852 H-loop/switch region; other site 471857003853 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 471857003854 Predicted transcriptional regulator [Transcription]; Region: COG2345 471857003855 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857003856 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 471857003857 FeS assembly protein SufB; Region: sufB; TIGR01980 471857003858 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 471857003859 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 471857003860 FeS assembly ATPase SufC; Region: sufC; TIGR01978 471857003861 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 471857003862 Walker A/P-loop; other site 471857003863 ATP binding site [chemical binding]; other site 471857003864 Q-loop/lid; other site 471857003865 ABC transporter signature motif; other site 471857003866 Walker B; other site 471857003867 D-loop; other site 471857003868 H-loop/switch region; other site 471857003869 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 471857003870 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 471857003871 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471857003872 catalytic residue [active] 471857003873 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 471857003874 trimerization site [polypeptide binding]; other site 471857003875 active site 471857003876 Domain of unknown function DUF59; Region: DUF59; cl00941 471857003877 Beta-lactamase; Region: Beta-lactamase; cl01009 471857003878 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 471857003879 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471857003880 Walker A/P-loop; other site 471857003881 ATP binding site [chemical binding]; other site 471857003882 Q-loop/lid; other site 471857003883 ABC transporter signature motif; other site 471857003884 Walker B; other site 471857003885 D-loop; other site 471857003886 H-loop/switch region; other site 471857003887 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471857003888 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471857003889 Walker A/P-loop; other site 471857003890 ATP binding site [chemical binding]; other site 471857003891 Q-loop/lid; other site 471857003892 ABC transporter signature motif; other site 471857003893 Walker B; other site 471857003894 D-loop; other site 471857003895 H-loop/switch region; other site 471857003896 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471857003897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857003898 dimer interface [polypeptide binding]; other site 471857003899 conserved gate region; other site 471857003900 putative PBP binding loops; other site 471857003901 ABC-ATPase subunit interface; other site 471857003902 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471857003903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857003904 dimer interface [polypeptide binding]; other site 471857003905 conserved gate region; other site 471857003906 putative PBP binding loops; other site 471857003907 ABC-ATPase subunit interface; other site 471857003908 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 471857003909 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471857003910 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 471857003911 active site 471857003912 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 471857003913 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 471857003914 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471857003915 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl01276 471857003916 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471857003917 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857003918 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857003919 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 471857003920 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471857003921 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857003922 Walker A/P-loop; other site 471857003923 ATP binding site [chemical binding]; other site 471857003924 Q-loop/lid; other site 471857003925 ABC transporter signature motif; other site 471857003926 Walker B; other site 471857003927 D-loop; other site 471857003928 H-loop/switch region; other site 471857003929 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 471857003930 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 471857003931 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857003932 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 471857003933 Walker A/P-loop; other site 471857003934 ATP binding site [chemical binding]; other site 471857003935 Q-loop/lid; other site 471857003936 ABC transporter signature motif; other site 471857003937 Walker B; other site 471857003938 D-loop; other site 471857003939 H-loop/switch region; other site 471857003940 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 471857003941 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 471857003942 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 471857003943 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 471857003944 catalytic triad [active] 471857003945 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 471857003946 sensory histidine kinase AtoS; Provisional; Region: PRK11360 471857003947 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 471857003948 metal binding site [ion binding]; metal-binding site 471857003949 active site 471857003950 I-site; other site 471857003951 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 471857003952 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 471857003953 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 471857003954 dimer interface [polypeptide binding]; other site 471857003955 putative radical transfer pathway; other site 471857003956 diiron center [ion binding]; other site 471857003957 tyrosyl radical; other site 471857003958 ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506 471857003959 Class I ribonucleotide reductase; Region: RNR_I; cd01679 471857003960 active site 471857003961 dimer interface [polypeptide binding]; other site 471857003962 catalytic residues [active] 471857003963 effector binding site; other site 471857003964 R2 peptide binding site; other site 471857003965 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 471857003966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857003967 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 471857003968 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471857003969 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 471857003970 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 471857003971 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 471857003972 dimer interface [polypeptide binding]; other site 471857003973 putative anticodon binding site; other site 471857003974 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 471857003975 motif 1; other site 471857003976 dimer interface [polypeptide binding]; other site 471857003977 active site 471857003978 motif 2; other site 471857003979 motif 3; other site 471857003980 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 471857003981 enoyl-CoA hydratase; Provisional; Region: PRK08260 471857003982 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471857003983 substrate binding site [chemical binding]; other site 471857003984 oxyanion hole (OAH) forming residues; other site 471857003985 trimer interface [polypeptide binding]; other site 471857003986 TIGR03084 family protein; Region: TIGR03084 471857003987 DinB superfamily; Region: DinB_2; cl00986 471857003988 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 471857003989 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857003990 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857003991 active site 471857003992 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 471857003993 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 471857003994 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 471857003995 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 471857003996 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471857003997 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 471857003998 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 471857003999 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 471857004000 carboxyltransferase (CT) interaction site; other site 471857004001 biotinylation site [posttranslational modification]; other site 471857004002 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857004003 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 471857004004 active site 471857004005 short chain dehydrogenase; Provisional; Region: PRK08278 471857004006 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857004007 NAD(P) binding site [chemical binding]; other site 471857004008 active site 471857004009 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 471857004010 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857004011 Carbon starvation protein CstA; Region: CstA; cl00856 471857004012 Protein of unknown function (DUF466); Region: DUF466; cl01082 471857004013 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 471857004014 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 471857004015 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 471857004016 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857004017 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857004018 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 471857004019 intersubunit interface [polypeptide binding]; other site 471857004020 active site 471857004021 zinc binding site [ion binding]; other site 471857004022 Na+ binding site [ion binding]; other site 471857004023 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 471857004024 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 471857004025 dimer interface [polypeptide binding]; other site 471857004026 active site 471857004027 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 471857004028 dimer interface [polypeptide binding]; other site 471857004029 active site 471857004030 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471857004031 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471857004032 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471857004033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857004034 dimer interface [polypeptide binding]; other site 471857004035 conserved gate region; other site 471857004036 putative PBP binding loops; other site 471857004037 ABC-ATPase subunit interface; other site 471857004038 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 471857004039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857004040 ABC-ATPase subunit interface; other site 471857004041 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471857004042 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471857004043 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857004044 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 471857004045 putative substrate binding site [chemical binding]; other site 471857004046 putative ATP binding site [chemical binding]; other site 471857004047 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 471857004048 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857004049 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 471857004050 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857004051 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857004052 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 471857004053 classical (c) SDRs; Region: SDR_c; cd05233 471857004054 NAD(P) binding site [chemical binding]; other site 471857004055 active site 471857004056 classical (c) SDRs; Region: SDR_c; cd05233 471857004057 NAD(P) binding site [chemical binding]; other site 471857004058 active site 471857004059 TetR family transcriptional regulator; Provisional; Region: PRK14996 471857004060 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857004061 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857004062 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857004063 active site 471857004064 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 471857004065 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 471857004066 FAD binding site [chemical binding]; other site 471857004067 substrate binding site [chemical binding]; other site 471857004068 catalytic base [active] 471857004069 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857004070 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857004071 active site 471857004072 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 471857004073 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: ACAD10_11_like; cd05154 471857004074 putative active site [active] 471857004075 putative substrate binding site [chemical binding]; other site 471857004076 ATP binding site [chemical binding]; other site 471857004077 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 471857004078 putative active site [active] 471857004079 putative catalytic site [active] 471857004080 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471857004081 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857004082 NAD(P) binding site [chemical binding]; other site 471857004083 active site 471857004084 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 471857004085 HSP70 interaction site [polypeptide binding]; other site 471857004086 Nuclease-related domain; Region: NERD; pfam08378 471857004087 Conserved TM helix; Region: TM_helix; pfam05552 471857004088 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471857004089 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471857004090 active site 471857004091 ATP binding site [chemical binding]; other site 471857004092 substrate binding site [chemical binding]; other site 471857004093 activation loop (A-loop); other site 471857004094 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 471857004095 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 471857004096 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471857004097 active site 471857004098 metal binding site [ion binding]; metal-binding site 471857004099 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 471857004100 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471857004101 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 471857004102 NAD(P) binding site [chemical binding]; other site 471857004103 catalytic residues [active] 471857004104 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 471857004105 substrate binding site [chemical binding]; other site 471857004106 selenophosphate synthetase; Provisional; Region: PRK00943 471857004107 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 471857004108 dimerization interface [polypeptide binding]; other site 471857004109 putative ATP binding site [chemical binding]; other site 471857004110 selenocysteine synthase; Provisional; Region: PRK04311 471857004111 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 471857004112 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471857004113 SelB subfamily. SelB is an elongation factor needed for the co-translational incorporation of selenocysteine. Selenocysteine is coded by a UGA stop codon in combination with a specific downstream mRNA hairpin. In bacteria, the C-terminal part of...; Region: SelB; cd04171 471857004114 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 471857004115 G1 box; other site 471857004116 putative GEF interaction site [polypeptide binding]; other site 471857004117 GTP/Mg2+ binding site [chemical binding]; other site 471857004118 Switch I region; other site 471857004119 G2 box; other site 471857004120 G3 box; other site 471857004121 Switch II region; other site 471857004122 G4 box; other site 471857004123 G5 box; other site 471857004124 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires...; Region: selB_II; cd03696 471857004125 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 471857004126 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471857004127 catalytic residues [active] 471857004128 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 471857004129 nudix motif; other site 471857004130 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471857004131 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471857004132 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 471857004133 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 471857004134 Walker A/P-loop; other site 471857004135 ATP binding site [chemical binding]; other site 471857004136 Q-loop/lid; other site 471857004137 ABC transporter signature motif; other site 471857004138 Walker B; other site 471857004139 D-loop; other site 471857004140 H-loop/switch region; other site 471857004141 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857004142 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 471857004143 hydrophobic ligand binding site; other site 471857004144 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 471857004145 nucleotide binding site/active site [active] 471857004146 HIT family signature motif; other site 471857004147 catalytic residue [active] 471857004148 Lsr2; Region: Lsr2; pfam11774 471857004149 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 471857004150 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471857004151 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471857004152 catalytic residue [active] 471857004153 hypothetical protein; Provisional; Region: PRK07906 471857004154 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 471857004155 putative metal binding site [ion binding]; other site 471857004156 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 471857004157 Uncharacterized conserved protein [Function unknown]; Region: COG1739 471857004158 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 471857004159 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 471857004160 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 471857004161 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 471857004162 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857004163 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 471857004164 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 471857004165 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 471857004166 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 471857004167 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 471857004168 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 471857004169 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 471857004170 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 471857004171 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 471857004172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 471857004173 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 471857004174 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 471857004175 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 471857004176 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 471857004177 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 471857004178 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 471857004179 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 471857004180 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 471857004181 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cl09719 471857004182 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 471857004183 helicase Cas3; Provisional; Region: PRK09694 471857004184 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 471857004185 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857004186 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471857004187 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 471857004188 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471857004189 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 471857004190 homodimer interface [polypeptide binding]; other site 471857004191 homotetramer interface [polypeptide binding]; other site 471857004192 active site pocket [active] 471857004193 cleavage site 471857004194 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471857004195 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857004196 CoA-transferase family III; Region: CoA_transf_3; cl00778 471857004197 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857004198 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857004199 active site 471857004200 FOG: CBS domain [General function prediction only]; Region: COG0517 471857004201 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 471857004202 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 471857004203 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 471857004204 heme-binding site [chemical binding]; other site 471857004205 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 471857004206 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471857004207 peptide synthase; Validated; Region: PRK05691 471857004208 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857004209 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 471857004210 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857004211 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857004212 NAD(P) binding site [chemical binding]; other site 471857004213 active site 471857004214 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 471857004215 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 471857004216 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980 471857004217 dimer interface [polypeptide binding]; other site 471857004218 [2Fe-2S] cluster binding site [ion binding]; other site 471857004219 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 471857004220 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 471857004221 Walker A/P-loop; other site 471857004222 ATP binding site [chemical binding]; other site 471857004223 Q-loop/lid; other site 471857004224 ABC transporter signature motif; other site 471857004225 Walker B; other site 471857004226 D-loop; other site 471857004227 H-loop/switch region; other site 471857004228 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 471857004229 dimer interface [polypeptide binding]; other site 471857004230 putative PBP binding regions; other site 471857004231 ABC-ATPase subunit interface; other site 471857004232 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 471857004233 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 471857004234 putative ligand binding residues [chemical binding]; other site 471857004235 precorrin-3B synthase; Region: CobG; TIGR02435 471857004236 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 471857004237 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 471857004238 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 471857004239 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 471857004240 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 471857004241 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 471857004242 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 471857004243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471857004244 cobyric acid synthase; Provisional; Region: PRK00784 471857004245 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471857004246 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 471857004247 catalytic triad [active] 471857004248 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 471857004249 CobD/Cbib protein; Region: CobD_Cbib; cl00561 471857004250 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 471857004251 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 471857004252 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 471857004253 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 471857004254 catalytic triad [active] 471857004255 hypothetical protein; Provisional; Region: PRK07908 471857004256 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471857004257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857004258 homodimer interface [polypeptide binding]; other site 471857004259 catalytic residue [active] 471857004260 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 471857004261 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a...; Region: CobA_CobO_BtuR; cd00561 471857004262 homodimer interface [polypeptide binding]; other site 471857004263 Walker A motif; other site 471857004264 ATP binding site [chemical binding]; other site 471857004265 hydroxycobalamin binding site [chemical binding]; other site 471857004266 Walker B motif; other site 471857004267 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857004268 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 471857004269 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase...; Region: vWA_Magnesium_chelatase; cd01451 471857004270 metal ion-dependent adhesion site (MIDAS); other site 471857004271 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471857004272 Coenzyme A binding pocket [chemical binding]; other site 471857004273 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 471857004274 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857004275 NAD(P) binding site [chemical binding]; other site 471857004276 active site 471857004277 Cytochrome P450; Region: p450; cl12078 471857004278 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 471857004279 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 471857004280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857004281 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 471857004282 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471857004283 NAD binding site [chemical binding]; other site 471857004284 catalytic residues [active] 471857004285 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 471857004286 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 471857004287 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 471857004288 active site 471857004289 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 471857004290 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471857004291 substrate binding site [chemical binding]; other site 471857004292 oxyanion hole (OAH) forming residues; other site 471857004293 trimer interface [polypeptide binding]; other site 471857004294 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 471857004295 DUF35 OB-fold domain; Region: DUF35; pfam01796 471857004296 lipid-transfer protein; Provisional; Region: PRK08256 471857004297 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 471857004298 active site 471857004299 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857004300 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857004301 active site 471857004302 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: ACAD10_11_like; cd05154 471857004303 putative active site [active] 471857004304 putative substrate binding site [chemical binding]; other site 471857004305 ATP binding site [chemical binding]; other site 471857004306 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 471857004307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857004308 NAD(P) binding site [chemical binding]; other site 471857004309 active site 471857004310 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 471857004311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857004312 NAD(P) binding site [chemical binding]; other site 471857004313 active site 471857004314 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 471857004315 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 471857004316 NAD binding site [chemical binding]; other site 471857004317 substrate binding site [chemical binding]; other site 471857004318 catalytic Zn binding site [ion binding]; other site 471857004319 structural Zn binding site [ion binding]; other site 471857004320 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857004321 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857004322 EthD protein; Region: EthD; cl06234 471857004323 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471857004324 putative acyltransferase; Provisional; Region: PRK05790 471857004325 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471857004326 dimer interface [polypeptide binding]; other site 471857004327 active site 471857004328 enoyl-CoA hydratase; Provisional; Region: PRK06688 471857004329 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471857004330 substrate binding site [chemical binding]; other site 471857004331 oxyanion hole (OAH) forming residues; other site 471857004332 trimer interface [polypeptide binding]; other site 471857004333 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 471857004334 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 471857004335 substrate binding site [chemical binding]; other site 471857004336 ATP binding site [chemical binding]; other site 471857004337 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 471857004338 Sodium:solute symporter family; Region: SSF; cl00456 471857004339 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 471857004340 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471857004341 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857004342 DNA-binding site [nucleotide binding]; DNA binding site 471857004343 UTRA domain; Region: UTRA; cl01230 471857004344 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471857004345 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency...; Region: ABC_subfamily_A; cd03263 471857004346 Walker A/P-loop; other site 471857004347 ATP binding site [chemical binding]; other site 471857004348 Q-loop/lid; other site 471857004349 ABC transporter signature motif; other site 471857004350 Walker B; other site 471857004351 D-loop; other site 471857004352 H-loop/switch region; other site 471857004353 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471857004354 putative Zn2+ binding site [ion binding]; other site 471857004355 putative DNA binding site [nucleotide binding]; other site 471857004356 dimerization interface [polypeptide binding]; other site 471857004357 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471857004358 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857004359 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 471857004360 putative dimerization interface [polypeptide binding]; other site 471857004361 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 471857004362 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 471857004363 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 471857004364 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 471857004365 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857004366 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471857004367 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 471857004368 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 471857004369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 471857004370 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 471857004371 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 471857004372 Walker A/P-loop; other site 471857004373 ATP binding site [chemical binding]; other site 471857004374 Q-loop/lid; other site 471857004375 ABC transporter signature motif; other site 471857004376 Walker B; other site 471857004377 D-loop; other site 471857004378 H-loop/switch region; other site 471857004379 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 471857004380 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 471857004381 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 471857004382 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 471857004383 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 471857004384 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 471857004385 trimer interface [polypeptide binding]; other site 471857004386 putative metal binding site [ion binding]; other site 471857004387 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 471857004388 active site 471857004389 catalytic residues [active] 471857004390 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 471857004391 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 471857004392 catalytic residues [active] 471857004393 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 471857004394 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471857004395 YCII-related domain; Region: YCII; cl00999 471857004396 metabolite-proton symporter; Region: 2A0106; TIGR00883 471857004397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857004398 putative substrate translocation pore; other site 471857004399 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 471857004400 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 471857004401 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471857004402 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857004403 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 471857004404 Walker A/P-loop; other site 471857004405 ATP binding site [chemical binding]; other site 471857004406 Q-loop/lid; other site 471857004407 ABC transporter signature motif; other site 471857004408 Walker B; other site 471857004409 D-loop; other site 471857004410 H-loop/switch region; other site 471857004411 acyl-CoA synthetase; Validated; Region: PRK05850 471857004412 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857004413 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857004414 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857004415 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 471857004416 active site 471857004417 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 471857004418 active site 471857004419 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471857004420 peptide synthase; Provisional; Region: PRK12467 471857004421 Condensation domain; Region: Condensation; cl09290 471857004422 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857004423 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857004424 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471857004425 Condensation domain; Region: Condensation; cl09290 471857004426 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857004427 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471857004428 Condensation domain; Region: Condensation; cl09290 471857004429 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 471857004430 Condensation domain; Region: Condensation; cl09290 471857004431 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857004432 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471857004433 Condensation domain; Region: Condensation; cl09290 471857004434 L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443 471857004435 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 471857004436 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857004437 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471857004438 Condensation domain; Region: Condensation; cl09290 471857004439 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 471857004440 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857004441 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857004442 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471857004443 Condensation domain; Region: Condensation; cl09290 471857004444 L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443 471857004445 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 471857004446 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857004447 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471857004448 peptide synthase; Provisional; Region: PRK12467 471857004449 Condensation domain; Region: Condensation; cl09290 471857004450 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857004451 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857004452 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471857004453 Condensation domain; Region: Condensation; cl09290 471857004454 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857004455 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471857004456 Condensation domain; Region: Condensation; cl09290 471857004457 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 471857004458 Condensation domain; Region: Condensation; cl09290 471857004459 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857004460 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471857004461 Condensation domain; Region: Condensation; cl09290 471857004462 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 471857004463 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857004464 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471857004465 Condensation domain; Region: Condensation; cl09290 471857004466 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 471857004467 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857004468 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857004469 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471857004470 Condensation domain; Region: Condensation; cl09290 471857004471 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 471857004472 Condensation domain; Region: Condensation; cl09290 471857004473 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 471857004474 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857004475 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857004476 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471857004477 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 471857004478 Condensation domain; Region: Condensation; cl09290 471857004479 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857004480 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471857004481 MbtH-like protein; Region: MbtH; cl01279 471857004482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471857004483 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 471857004484 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 471857004485 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471857004486 substrate binding pocket [chemical binding]; other site 471857004487 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 471857004488 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471857004489 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857004490 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 471857004491 putative dimerization interface [polypeptide binding]; other site 471857004492 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 471857004493 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 471857004494 Predicted acyl esterases [General function prediction only]; Region: COG2936 471857004495 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471857004496 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 471857004497 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 471857004498 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 471857004499 Putative cyclase; Region: Cyclase; cl00814 471857004500 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 471857004501 CoA-transferase family III; Region: CoA_transf_3; cl00778 471857004502 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 471857004503 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-...; Region: PA_degradation_oxidoreductase_like; cd06214 471857004504 FAD binding pocket [chemical binding]; other site 471857004505 FAD binding motif [chemical binding]; other site 471857004506 phosphate binding motif [ion binding]; other site 471857004507 beta-alpha-beta structure motif; other site 471857004508 NAD(p) ribose binding residues [chemical binding]; other site 471857004509 NAD binding pocket [chemical binding]; other site 471857004510 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 471857004511 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471857004512 catalytic loop [active] 471857004513 iron binding site [ion binding]; other site 471857004514 Chlorophyllase; Region: Chlorophyllase; cl15281 471857004515 ornithine carbamoyltransferase; Provisional; Region: PRK00779 471857004516 hypothetical protein; Provisional; Region: PRK06185 471857004517 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 471857004518 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 471857004519 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857004520 active site 471857004521 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: ACAD10_11_like; cd05154 471857004522 putative active site [active] 471857004523 putative substrate binding site [chemical binding]; other site 471857004524 ATP binding site [chemical binding]; other site 471857004525 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 471857004526 classical (c) SDRs; Region: SDR_c; cd05233 471857004527 NAD(P) binding site [chemical binding]; other site 471857004528 active site 471857004529 PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong...; Region: PA_GCPII_like; cd02121 471857004530 apical/protease domain interface [polypeptide binding]; other site 471857004531 substrate binding [chemical binding]; other site 471857004532 dimer interface [polypeptide binding]; other site 471857004533 M28, and M42; Region: Zinc_peptidase_like; cl14876 471857004534 metal binding site [ion binding]; metal-binding site 471857004535 Transferrin receptor-like dimerisation domain; Region: TFR_dimer; pfam04253 471857004536 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 471857004537 metabolite-proton symporter; Region: 2A0106; TIGR00883 471857004538 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857004539 putative substrate translocation pore; other site 471857004540 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471857004541 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857004542 Bacterial transcriptional regulator; Region: IclR; pfam01614 471857004543 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise...; Region: Rieske_RO_ferredoxin; cd03528 471857004544 [2Fe-2S] cluster binding site [ion binding]; other site 471857004545 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 471857004546 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857004547 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 471857004548 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 471857004549 [2Fe-2S] cluster binding site [ion binding]; other site 471857004550 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 471857004551 putative alpha subunit interface [polypeptide binding]; other site 471857004552 putative active site [active] 471857004553 putative substrate binding site [chemical binding]; other site 471857004554 Fe binding site [ion binding]; other site 471857004555 mycothiol-dependent formaldehyde dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 471857004556 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 471857004557 NAD binding site [chemical binding]; other site 471857004558 catalytic Zn binding site [ion binding]; other site 471857004559 substrate binding site [chemical binding]; other site 471857004560 structural Zn binding site [ion binding]; other site 471857004561 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471857004562 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 471857004563 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 471857004564 dimer interface [polypeptide binding]; other site 471857004565 glycine-pyridoxal phosphate binding site [chemical binding]; other site 471857004566 active site 471857004567 folate binding site [chemical binding]; other site 471857004568 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 471857004569 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 471857004570 Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767 471857004571 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 471857004572 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 471857004573 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 471857004574 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 471857004575 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857004576 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 471857004577 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 471857004578 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 471857004579 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 471857004580 Transcriptional regulators [Transcription]; Region: GntR; COG1802 471857004581 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857004582 DNA-binding site [nucleotide binding]; DNA binding site 471857004583 FCD domain; Region: FCD; cl11656 471857004584 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 471857004585 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 471857004586 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 471857004587 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 471857004588 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 471857004589 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 471857004590 putative active site [active] 471857004591 putative substrate binding site [chemical binding]; other site 471857004592 putative cosubstrate binding site; other site 471857004593 catalytic site [active] 471857004594 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 471857004595 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 471857004596 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 471857004597 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471857004598 DNA binding site [nucleotide binding] 471857004599 active site 471857004600 Int/Topo IB signature motif; other site 471857004601 homogentisate 1,2-dioxygenase; Region: HgmA; cl10473 471857004602 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 471857004603 DNA binding site [nucleotide binding] 471857004604 GAF domain; Region: GAF; cl00853 471857004605 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 471857004606 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 471857004607 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 471857004608 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 471857004609 active site 471857004610 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471857004611 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857004612 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471857004613 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 471857004614 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857004615 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 471857004616 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471857004617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 471857004618 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857004619 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471857004620 Domain of unknown function (DUF336); Region: DUF336; cl01249 471857004621 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_Nitrate-R-NapA-like; cd02754 471857004622 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 471857004623 [4Fe-4S] binding site [ion binding]; other site 471857004624 molybdopterin cofactor binding site; other site 471857004625 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of...; Region: MopB_CT_Fdh-Nap-like; cd00508 471857004626 molybdopterin cofactor binding site; other site 471857004627 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 471857004628 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 471857004629 metabolite-proton symporter; Region: 2A0106; TIGR00883 471857004630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857004631 putative substrate translocation pore; other site 471857004632 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 471857004633 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 471857004634 homodimer interface [polypeptide binding]; other site 471857004635 substrate-cofactor binding pocket; other site 471857004636 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857004637 catalytic residue [active] 471857004638 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 471857004639 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471857004640 active site 471857004641 catalytic tetrad [active] 471857004642 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 471857004643 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 471857004644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 471857004645 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857004646 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857004647 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471857004648 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 471857004649 DNA binding site [nucleotide binding] 471857004650 Int/Topo IB signature motif; other site 471857004651 active site 471857004652 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 471857004653 Fe-S containing; Region: FDH-beta; TIGR01582 471857004654 Fe-S containing; Region: FDH-beta; TIGR01582 471857004655 4Fe-4S binding domain; Region: Fer4; cl02805 471857004656 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 471857004657 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 471857004658 molybdopterin cofactor binding site; other site 471857004659 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 471857004660 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 471857004661 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 471857004662 molybdopterin cofactor binding site; other site 471857004663 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 471857004664 Muconolactone delta-isomerase; Region: MIase; cl01992 471857004665 Actinobacterial; Region: catachol_actin; TIGR02438 471857004666 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl01383 471857004667 Active site [active] 471857004668 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 471857004669 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471857004670 putative NAD(P) binding site [chemical binding]; other site 471857004671 active site 471857004672 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471857004673 DNA binding residues [nucleotide binding] 471857004674 dimerization interface [polypeptide binding]; other site 471857004675 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 471857004676 active site 471857004677 metal binding site [ion binding]; metal-binding site 471857004678 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857004679 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857004680 Domain of unknown function (DUF385); Region: DUF385; cl04387 471857004681 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 471857004682 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857004683 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 471857004684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471857004685 S-adenosylmethionine binding site [chemical binding]; other site 471857004686 YCII-related domain; Region: YCII; cl00999 471857004687 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 471857004688 LysE type translocator; Region: LysE; cl00565 471857004689 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins...; Region: GH25_BacA-like; cd06418 471857004690 active site 471857004691 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 471857004692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857004693 putative substrate translocation pore; other site 471857004694 Cytochrome P450; Region: p450; cl12078 471857004695 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471857004696 dimerization interface [polypeptide binding]; other site 471857004697 putative DNA binding site [nucleotide binding]; other site 471857004698 putative Zn2+ binding site [ion binding]; other site 471857004699 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 471857004700 Sulfate transporter family; Region: Sulfate_transp; cl00967 471857004701 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 471857004702 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 471857004703 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 471857004704 Alpha/beta hydrolase of unknown function (DUF1023); Region: DUF1023; pfam06259 471857004705 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 471857004706 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 471857004707 DNA binding residues [nucleotide binding] 471857004708 drug binding residues [chemical binding]; other site 471857004709 dimer interface [polypeptide binding]; other site 471857004710 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 471857004711 Active site [active] 471857004712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857004713 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471857004714 putative substrate translocation pore; other site 471857004715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857004716 N-acetyltransferase; Region: Acetyltransf_2; cl00949 471857004717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857004718 putative substrate translocation pore; other site 471857004719 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471857004720 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857004721 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 471857004722 putative dimerization interface [polypeptide binding]; other site 471857004723 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 471857004724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471857004725 S-adenosylmethionine binding site [chemical binding]; other site 471857004726 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471857004727 dimerization interface [polypeptide binding]; other site 471857004728 putative DNA binding site [nucleotide binding]; other site 471857004729 putative Zn2+ binding site [ion binding]; other site 471857004730 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 471857004731 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471857004732 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 471857004733 Phage integrase family; Region: Phage_integrase; pfam00589 471857004734 C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family include the bacteriophage lambda integrase, the...; Region: INT_REC_C; cd01182 471857004735 DNA binding site [nucleotide binding] 471857004736 Int/Topo IB signature motif; other site 471857004737 active site 471857004738 catalytic residues [active] 471857004739 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 471857004740 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 471857004741 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 471857004742 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 471857004743 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 471857004744 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 471857004745 active site 471857004746 Predicted amidohydrolase [General function prediction only]; Region: COG0388 471857004747 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 471857004748 putative active site [active] 471857004749 catalytic triad [active] 471857004750 putative dimer interface [polypeptide binding]; other site 471857004751 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 471857004752 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 471857004753 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 471857004754 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471857004755 DNA binding site [nucleotide binding] 471857004756 Int/Topo IB signature motif; other site 471857004757 active site 471857004758 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 471857004759 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 471857004760 putative active site [active] 471857004761 catalytic site [active] 471857004762 putative metal binding site [ion binding]; other site 471857004763 putative inner membrane protein; Provisional; Region: PRK11099 471857004764 YeeE/YedE family (DUF395); Region: DUF395; cl01018 471857004765 YeeE/YedE family (DUF395); Region: DUF395; cl01018 471857004766 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cl00436 471857004767 CPxP motif; other site 471857004768 YCII-related domain; Region: YCII; cl00999 471857004769 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 471857004770 active site 471857004771 catalytic triad [active] 471857004772 oxyanion hole [active] 471857004773 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 471857004774 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 471857004775 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 471857004776 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 471857004777 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (...; Region: PI3Kc_like; cl00119 471857004778 Protein of unknown function (DUF3090); Region: DUF3090; cl12832 471857004779 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471857004780 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 471857004781 dimer interface [polypeptide binding]; other site 471857004782 catalytic triad [active] 471857004783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471857004784 S-adenosylmethionine binding site [chemical binding]; other site 471857004785 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471857004786 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 471857004787 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 471857004788 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471857004789 Walker A/P-loop; other site 471857004790 ATP binding site [chemical binding]; other site 471857004791 Q-loop/lid; other site 471857004792 ABC transporter signature motif; other site 471857004793 Walker B; other site 471857004794 D-loop; other site 471857004795 H-loop/switch region; other site 471857004796 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471857004797 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471857004798 Walker A/P-loop; other site 471857004799 ATP binding site [chemical binding]; other site 471857004800 Q-loop/lid; other site 471857004801 ABC transporter signature motif; other site 471857004802 Walker B; other site 471857004803 D-loop; other site 471857004804 H-loop/switch region; other site 471857004805 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 471857004806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857004807 dimer interface [polypeptide binding]; other site 471857004808 conserved gate region; other site 471857004809 putative PBP binding loops; other site 471857004810 ABC-ATPase subunit interface; other site 471857004811 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471857004812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857004813 dimer interface [polypeptide binding]; other site 471857004814 conserved gate region; other site 471857004815 putative PBP binding loops; other site 471857004816 ABC-ATPase subunit interface; other site 471857004817 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 471857004818 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471857004819 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 471857004820 SxDxEG motif; other site 471857004821 active site 471857004822 metal binding site [ion binding]; metal-binding site 471857004823 homopentamer interface [polypeptide binding]; other site 471857004824 hypothetical protein; Provisional; Region: PRK07906 471857004825 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 471857004826 putative metal binding site [ion binding]; other site 471857004827 malate dehydrogenase; Provisional; Region: PRK05442 471857004828 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 471857004829 NAD(P) binding site [chemical binding]; other site 471857004830 dimer interface [polypeptide binding]; other site 471857004831 malate binding site [chemical binding]; other site 471857004832 Predicted integral membrane protein [Function unknown]; Region: COG5522; cl02331 471857004833 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 471857004834 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 471857004835 active site 471857004836 Zn binding site [ion binding]; other site 471857004837 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471857004838 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 471857004839 catalytic core [active] 471857004840 Bacitracin resistance protein BacA; Region: BacA; cl00858 471857004841 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 471857004842 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471857004843 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471857004844 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 471857004845 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 471857004846 active site 471857004847 catalytic tetrad [active] 471857004848 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 471857004849 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 471857004850 FAD binding domain; Region: FAD_binding_4; pfam01565 471857004851 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 471857004852 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 471857004853 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 471857004854 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 471857004855 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 471857004856 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 471857004857 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 471857004858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857004859 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857004860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857004861 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471857004862 NAD(P) binding site [chemical binding]; other site 471857004863 active site 471857004864 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 471857004865 hydrophobic ligand binding site; other site 471857004866 Membrane transport protein; Region: Mem_trans; cl09117 471857004867 bile acid transporter; Region: bass; TIGR00841 471857004868 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 471857004869 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a...; Region: GT1_AviGT4_like; cd03802 471857004870 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471857004871 putative ADP-binding pocket [chemical binding]; other site 471857004872 Tannase and feruloyl esterase; Region: Tannase; pfam07519 471857004873 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 471857004874 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 471857004875 active site 471857004876 DNA binding site [nucleotide binding] 471857004877 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 471857004878 DNA binding site [nucleotide binding] 471857004879 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 471857004880 Leucine carboxyl methyltransferase; Region: LCM; cl01306 471857004881 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 471857004882 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 471857004883 active site 471857004884 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471857004885 NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152 471857004886 NAD(P) binding site [chemical binding]; other site 471857004887 catalytic residues [active] 471857004888 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 471857004889 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 471857004890 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857004891 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 471857004892 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 471857004893 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 471857004894 Sulfatase; Region: Sulfatase; cl10460 471857004895 PhoD-like phosphatase; Region: PhoD; pfam09423 471857004896 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 471857004897 putative active site [active] 471857004898 putative metal binding site [ion binding]; other site 471857004899 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 471857004900 heat shock protein 90; Provisional; Region: PRK05218 471857004901 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471857004902 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 471857004903 putative active site [active] 471857004904 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 471857004905 SpoOM protein; Region: Spo0M; pfam07070 471857004906 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 471857004907 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 471857004908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471857004909 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857004910 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857004911 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857004912 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical...; Region: CHS_like; cd00831 471857004913 malonyl-CoA binding site [chemical binding]; other site 471857004914 dimer interface [polypeptide binding]; other site 471857004915 active site 471857004916 product binding site; other site 471857004917 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 471857004918 metal binding site 2 [ion binding]; metal-binding site 471857004919 putative DNA binding helix; other site 471857004920 metal binding site 1 [ion binding]; metal-binding site 471857004921 dimer interface [polypeptide binding]; other site 471857004922 structural Zn2+ binding site [ion binding]; other site 471857004923 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 471857004924 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 471857004925 tetramer interface [polypeptide binding]; other site 471857004926 heme binding pocket [chemical binding]; other site 471857004927 NADPH binding site [chemical binding]; other site 471857004928 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 471857004929 dimer interface [polypeptide binding]; other site 471857004930 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 471857004931 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471857004932 putative NAD(P) binding site [chemical binding]; other site 471857004933 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 471857004934 catalytic residues [active] 471857004935 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 471857004936 Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353 471857004937 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 471857004938 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 471857004939 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 471857004940 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 471857004941 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 471857004942 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 471857004943 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471857004944 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471857004945 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471857004946 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857004947 non-specific DNA binding site [nucleotide binding]; other site 471857004948 salt bridge; other site 471857004949 sequence-specific DNA binding site [nucleotide binding]; other site 471857004950 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 471857004951 active site 471857004952 NTP binding site [chemical binding]; other site 471857004953 metal binding triad [ion binding]; metal-binding site 471857004954 antibiotic binding site [chemical binding]; other site 471857004955 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 471857004956 DinB superfamily; Region: DinB_2; cl00986 471857004957 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 471857004958 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 471857004959 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 471857004960 Cupin domain; Region: Cupin_2; cl09118 471857004961 Cupin domain; Region: Cupin_2; cl09118 471857004962 salicylate hydroxylase; Provisional; Region: PRK08163 471857004963 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857004964 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471857004965 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857004966 Bacterial transcriptional regulator; Region: IclR; pfam01614 471857004967 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 471857004968 OsmC-like protein; Region: OsmC; cl00767 471857004969 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 471857004970 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857004971 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 471857004972 NAD(P) binding site [chemical binding]; other site 471857004973 active site 471857004974 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 471857004975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857004976 putative substrate translocation pore; other site 471857004977 Condensation domain; Region: Condensation; cl09290 471857004978 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 471857004979 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 471857004980 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857004981 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471857004982 Condensation domain; Region: Condensation; cl09290 471857004983 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 471857004984 Condensation domain; Region: Condensation; cl09290 471857004985 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 471857004986 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857004987 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471857004988 Condensation domain; Region: Condensation; cl09290 471857004989 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 471857004990 Condensation domain; Region: Condensation; cl09290 471857004991 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 471857004992 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 471857004993 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 471857004994 Walker A/P-loop; other site 471857004995 ATP binding site [chemical binding]; other site 471857004996 Q-loop/lid; other site 471857004997 ABC transporter signature motif; other site 471857004998 Walker B; other site 471857004999 D-loop; other site 471857005000 H-loop/switch region; other site 471857005001 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 471857005002 ABC-ATPase subunit interface; other site 471857005003 dimer interface [polypeptide binding]; other site 471857005004 putative PBP binding regions; other site 471857005005 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 471857005006 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 471857005007 ABC-ATPase subunit interface; other site 471857005008 dimer interface [polypeptide binding]; other site 471857005009 putative PBP binding regions; other site 471857005010 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 471857005011 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 471857005012 intersubunit interface [polypeptide binding]; other site 471857005013 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 471857005014 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 471857005015 FAD binding pocket [chemical binding]; other site 471857005016 FAD binding motif [chemical binding]; other site 471857005017 phosphate binding motif [ion binding]; other site 471857005018 NAD binding pocket [chemical binding]; other site 471857005019 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471857005020 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 471857005021 Isochorismatase family; Region: Isochorismatase; pfam00857 471857005022 catalytic triad [active] 471857005023 conserved cis-peptide bond; other site 471857005024 2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275 471857005025 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857005026 chorismate binding enzyme; Region: Chorismate_bind; cl10555 471857005027 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 471857005028 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 471857005029 Sulfate transporter family; Region: Sulfate_transp; cl00967 471857005030 Permease family; Region: Xan_ur_permease; pfam00860 471857005031 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 471857005032 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 471857005033 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 471857005034 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 471857005035 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 471857005036 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 471857005037 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 471857005038 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 471857005039 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 471857005040 putative hydrophobic ligand binding site [chemical binding]; other site 471857005041 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 471857005042 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 471857005043 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 471857005044 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 471857005045 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; pfam09663 471857005046 ring-opening amidohydrolases; Region: amido_AtzD_TrzD; TIGR02714 471857005047 amidase; Provisional; Region: PRK07486 471857005048 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 471857005049 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 471857005050 active site 471857005051 metal binding site [ion binding]; metal-binding site 471857005052 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471857005053 active site 471857005054 metal binding site [ion binding]; metal-binding site 471857005055 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857005056 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857005057 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 471857005058 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 471857005059 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 471857005060 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 471857005061 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 471857005062 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 471857005063 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471857005064 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 471857005065 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471857005066 catalytic residue [active] 471857005067 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 471857005068 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 471857005069 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 471857005070 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 471857005071 tetramer interface [polypeptide binding]; other site 471857005072 heme binding pocket [chemical binding]; other site 471857005073 NADPH binding site [chemical binding]; other site 471857005074 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 471857005075 metal binding site 2 [ion binding]; metal-binding site 471857005076 putative DNA binding helix; other site 471857005077 metal binding site 1 [ion binding]; metal-binding site 471857005078 dimer interface [polypeptide binding]; other site 471857005079 structural Zn2+ binding site [ion binding]; other site 471857005080 CHAT domain; Region: CHAT; cl02083 471857005081 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 471857005082 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 471857005083 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 471857005084 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 471857005085 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 471857005086 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 471857005087 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 471857005088 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 471857005089 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 471857005090 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the...; Region: AhpF_NTD_N; cd02974 471857005091 catalytic residue [active] 471857005092 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 471857005093 catalytic residues [active] 471857005094 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857005095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857005096 peroxiredoxin; Region: AhpC; TIGR03137 471857005097 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015 471857005098 dimer interface [polypeptide binding]; other site 471857005099 decamer (pentamer of dimers) interface [polypeptide binding]; other site 471857005100 catalytic triad [active] 471857005101 peroxidatic and resolving cysteines [active] 471857005102 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 471857005103 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857005104 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 471857005105 Peptidase M14-like domain of carboxypeptidase (CP) T (CPT), CPT belongs to the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding CPs which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a...; Region: M14_CPT; cd03859 471857005106 putative active site [active] 471857005107 Zn-binding site [ion binding]; other site 471857005108 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 471857005109 metal binding site 2 [ion binding]; metal-binding site 471857005110 putative DNA binding helix; other site 471857005111 metal binding site 1 [ion binding]; metal-binding site 471857005112 dimer interface [polypeptide binding]; other site 471857005113 structural Zn2+ binding site [ion binding]; other site 471857005114 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 471857005115 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 471857005116 dimer interface [polypeptide binding]; other site 471857005117 putative PBP binding regions; other site 471857005118 ABC-ATPase subunit interface; other site 471857005119 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 471857005120 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 471857005121 intersubunit interface [polypeptide binding]; other site 471857005122 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 471857005123 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 471857005124 Walker A/P-loop; other site 471857005125 ATP binding site [chemical binding]; other site 471857005126 Q-loop/lid; other site 471857005127 ABC transporter signature motif; other site 471857005128 Walker B; other site 471857005129 D-loop; other site 471857005130 H-loop/switch region; other site 471857005131 BioY family; Region: BioY; cl00560 471857005132 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 471857005133 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471857005134 nucleophilic elbow; other site 471857005135 catalytic triad; other site 471857005136 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 471857005137 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857005138 Bacterial transcriptional regulator; Region: IclR; pfam01614 471857005139 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 471857005140 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 471857005141 tetramer interface [polypeptide binding]; other site 471857005142 TPP-binding site [chemical binding]; other site 471857005143 heterodimer interface [polypeptide binding]; other site 471857005144 phosphorylation loop region [posttranslational modification] 471857005145 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 471857005146 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 471857005147 alpha subunit interface [polypeptide binding]; other site 471857005148 TPP binding site [chemical binding]; other site 471857005149 heterodimer interface [polypeptide binding]; other site 471857005150 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471857005151 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471857005152 E3 interaction surface; other site 471857005153 lipoyl attachment site [posttranslational modification]; other site 471857005154 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 471857005155 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 471857005156 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 471857005157 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 471857005158 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 471857005159 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 471857005160 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; cl01902 471857005161 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 471857005162 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 471857005163 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and 7-...; Region: Ntn_PGA_like; cd03747 471857005164 active site 471857005165 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; cl09205 471857005166 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 471857005167 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 471857005168 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 471857005169 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 471857005170 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 471857005171 active site 471857005172 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 471857005173 catalytic residues [active] 471857005174 catalytic nucleophile [active] 471857005175 Presynaptic Site I dimer interface [polypeptide binding]; other site 471857005176 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 471857005177 Synaptic Flat tetramer interface [polypeptide binding]; other site 471857005178 Synaptic Site I dimer interface [polypeptide binding]; other site 471857005179 DNA binding site [nucleotide binding] 471857005180 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 471857005181 DNA-binding interface [nucleotide binding]; DNA binding site 471857005182 PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 471857005183 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857005184 Walker A/P-loop; other site 471857005185 ATP binding site [chemical binding]; other site 471857005186 Q-loop/lid; other site 471857005187 ABC transporter signature motif; other site 471857005188 Walker B; other site 471857005189 D-loop; other site 471857005190 H-loop/switch region; other site 471857005191 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 471857005192 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 471857005193 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 471857005194 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 471857005195 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 471857005196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471857005197 S-adenosylmethionine binding site [chemical binding]; other site 471857005198 Transcriptional regulators [Transcription]; Region: FadR; COG2186 471857005199 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857005200 DNA-binding site [nucleotide binding]; DNA binding site 471857005201 FCD domain; Region: FCD; cl11656 471857005202 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 471857005203 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 471857005204 acyl-CoA synthetase; Validated; Region: PRK07787 471857005205 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857005206 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 471857005207 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 471857005208 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 471857005209 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 471857005210 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471857005211 Protein of unknown function, DUF488; Region: DUF488; cl01246 471857005212 Cupin domain; Region: Cupin_2; cl09118 471857005213 Protein of unknown function (DUF421); Region: DUF421; cl00990 471857005214 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 471857005215 Thymidine kinase; Region: TK; cl00631 471857005216 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 471857005217 Ligand binding site [chemical binding]; other site 471857005218 Putative Catalytic site [active] 471857005219 DXD motif; other site 471857005220 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 471857005221 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 471857005222 putative active site [active] 471857005223 catalytic triad [active] 471857005224 putative dimer interface [polypeptide binding]; other site 471857005225 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 471857005226 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 471857005227 active site 471857005228 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 471857005229 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471857005230 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 471857005231 Walker A/P-loop; other site 471857005232 ATP binding site [chemical binding]; other site 471857005233 Q-loop/lid; other site 471857005234 ABC transporter signature motif; other site 471857005235 Walker B; other site 471857005236 D-loop; other site 471857005237 H-loop/switch region; other site 471857005238 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 471857005239 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 471857005240 Walker A/P-loop; other site 471857005241 ATP binding site [chemical binding]; other site 471857005242 Q-loop/lid; other site 471857005243 ABC transporter signature motif; other site 471857005244 Walker B; other site 471857005245 D-loop; other site 471857005246 H-loop/switch region; other site 471857005247 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 471857005248 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 471857005249 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 471857005250 active site 471857005251 catalytic triad [active] 471857005252 oxyanion hole [active] 471857005253 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 471857005254 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857005255 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 471857005256 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 471857005257 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cl00279 471857005258 active site 471857005259 5'-3' exonuclease; Region: 53EXOc; smart00475 471857005260 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 471857005261 active site 471857005262 metal binding site 1 [ion binding]; metal-binding site 471857005263 putative 5' ssDNA interaction site; other site 471857005264 metal binding site 3; metal-binding site 471857005265 metal binding site 2 [ion binding]; metal-binding site 471857005266 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 471857005267 putative DNA binding site [nucleotide binding]; other site 471857005268 putative metal binding site [ion binding]; other site 471857005269 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471857005270 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 471857005271 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471857005272 ATP binding site [chemical binding]; other site 471857005273 putative Mg++ binding site [ion binding]; other site 471857005274 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857005275 nucleotide binding region [chemical binding]; other site 471857005276 ATP-binding site [chemical binding]; other site 471857005277 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 471857005278 diacylglycerol kinase; Reviewed; Region: PRK11914 471857005279 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 471857005280 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 471857005281 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 471857005282 Predicted transcriptional regulator [Transcription]; Region: COG2378 471857005283 Predicted transcriptional regulator [Transcription]; Region: COG2378 471857005284 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 471857005285 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 471857005286 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 471857005287 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 471857005288 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 471857005289 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 471857005290 MOSC domain; Region: MOSC; pfam03473 471857005291 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 471857005292 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded...; Region: proteasome_protease_HslV; cd01906 471857005293 active site 471857005294 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded...; Region: proteasome_protease_HslV; cd01906 471857005295 active site 471857005296 Pup-like protein; Region: Pup; cl05289 471857005297 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 471857005298 Pup-ligase protein; Region: Pup_ligase; pfam03136 471857005299 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 471857005300 active site 471857005301 catalytic tetrad [active] 471857005302 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 471857005303 proteasome ATPase; Region: pup_AAA; TIGR03689 471857005304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471857005305 Walker A motif; other site 471857005306 ATP binding site [chemical binding]; other site 471857005307 Walker B motif; other site 471857005308 arginine finger; other site 471857005309 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 471857005310 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471857005311 S-adenosylmethionine binding site [chemical binding]; other site 471857005312 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 471857005313 active site 471857005314 putative substrate binding region [chemical binding]; other site 471857005315 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cd02205 471857005316 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 471857005317 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 471857005318 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 471857005319 P-loop; other site 471857005320 Magnesium ion binding site [ion binding]; other site 471857005321 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 471857005322 Magnesium ion binding site [ion binding]; other site 471857005323 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471857005324 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 471857005325 ATP phosphoribosyltransferase; Region: HisG; cl15266 471857005326 HisG, C-terminal domain; Region: HisG_C; cl06867 471857005327 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 471857005328 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471857005329 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 471857005330 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 471857005331 motif II; other site 471857005332 PAC2 family; Region: PAC2; cl00847 471857005333 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471857005334 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471857005335 active site 471857005336 metal binding site [ion binding]; metal-binding site 471857005337 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471857005338 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471857005339 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 471857005340 active site 471857005341 HIGH motif; other site 471857005342 nucleotide binding site [chemical binding]; other site 471857005343 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471857005344 active site 471857005345 KMSKS motif; other site 471857005346 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 471857005347 putative tRNA binding surface [nucleotide binding]; other site 471857005348 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857005349 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857005350 Cytochrome P450; Region: p450; cl12078 471857005351 ferulate 5-hydroxylase; Region: PLN02183 471857005352 Peptidase S8 family domain, uncharacterized subfamily 12; Region: Peptidases_S8_12; cd07480 471857005353 active site 471857005354 catalytic triad [active] 471857005355 Clp amino terminal domain; Region: Clp_N; pfam02861 471857005356 Clp amino terminal domain; Region: Clp_N; pfam02861 471857005357 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 471857005358 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471857005359 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 471857005360 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857005361 ferrochelatase; Reviewed; Region: hemH; PRK00035 471857005362 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 471857005363 C-terminal domain interface [polypeptide binding]; other site 471857005364 active site 471857005365 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 471857005366 active site 471857005367 N-terminal domain interface [polypeptide binding]; other site 471857005368 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 471857005369 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 471857005370 NAD binding site [chemical binding]; other site 471857005371 homotetramer interface [polypeptide binding]; other site 471857005372 homodimer interface [polypeptide binding]; other site 471857005373 substrate binding site [chemical binding]; other site 471857005374 active site 471857005375 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 471857005376 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 471857005377 NAD(P) binding site [chemical binding]; other site 471857005378 homotetramer interface [polypeptide binding]; other site 471857005379 homodimer interface [polypeptide binding]; other site 471857005380 active site 471857005381 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 471857005382 hypothetical protein; Provisional; Region: PRK13685 471857005383 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471857005384 metal ion-dependent adhesion site (MIDAS); other site 471857005385 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 471857005386 Protein of unknown function DUF58; Region: DUF58; pfam01882 471857005387 MoxR-like ATPases [General function prediction only]; Region: COG0714 471857005388 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471857005389 Walker A motif; other site 471857005390 ATP binding site [chemical binding]; other site 471857005391 Walker B motif; other site 471857005392 arginine finger; other site 471857005393 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857005394 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 471857005395 GTP binding site [chemical binding]; other site 471857005396 aconitate hydratase; Validated; Region: PRK09277 471857005397 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 471857005398 substrate binding site [chemical binding]; other site 471857005399 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 471857005400 ligand binding site [chemical binding]; other site 471857005401 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 471857005402 substrate binding site [chemical binding]; other site 471857005403 probable methyltransferase; Region: TIGR03438 471857005404 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 471857005405 TIGR03442 family protein; Region: TIGR03442 471857005406 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 471857005407 putative active site [active] 471857005408 putative dimer interface [polypeptide binding]; other site 471857005409 TIGR03440 family protein; Region: unchr_TIGR03440 471857005410 DinB superfamily; Region: DinB_2; cl00986 471857005411 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 471857005412 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 471857005413 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857005414 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 471857005415 putative dimerization interface [polypeptide binding]; other site 471857005416 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 471857005417 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 471857005418 NAD(P) binding site [chemical binding]; other site 471857005419 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857005420 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857005421 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 471857005422 Domain of unknown function DUF21; Region: DUF21; pfam01595 471857005423 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471857005424 Transporter associated domain; Region: CorC_HlyC; cl08393 471857005425 Domain of unknown function DUF21; Region: DUF21; pfam01595 471857005426 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471857005427 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 471857005428 DNA binding residues [nucleotide binding] 471857005429 putative dimer interface [polypeptide binding]; other site 471857005430 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 471857005431 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857005432 Uncharacterised ACR, COG1259; Region: DUF151; cl00553 471857005433 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 471857005434 DNA binding residues [nucleotide binding] 471857005435 dimer interface [polypeptide binding]; other site 471857005436 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471857005437 phosphopeptide binding site; other site 471857005438 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 471857005439 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 471857005440 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857005441 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857005442 enoyl-CoA hydratase; Provisional; Region: PRK06142 471857005443 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471857005444 substrate binding site [chemical binding]; other site 471857005445 oxyanion hole (OAH) forming residues; other site 471857005446 trimer interface [polypeptide binding]; other site 471857005447 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 471857005448 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 471857005449 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 471857005450 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 471857005451 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471857005452 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471857005453 catalytic residue [active] 471857005454 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 471857005455 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857005456 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857005457 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 471857005458 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 471857005459 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857005460 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471857005461 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471857005462 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 471857005463 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor...; Region: FhuD; cd01146 471857005464 siderophore binding site; other site 471857005465 Cytochrome P450; Region: p450; cl12078 471857005466 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 471857005467 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857005468 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 471857005469 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 471857005470 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 471857005471 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857005472 Cytochrome P450; Region: p450; cl12078 471857005473 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 471857005474 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 471857005475 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 471857005476 classical (c) SDRs; Region: SDR_c; cd05233 471857005477 NAD(P) binding site [chemical binding]; other site 471857005478 active site 471857005479 pyruvate dehydrogenase; Provisional; Region: PRK06546 471857005480 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 471857005481 PYR/PP interface [polypeptide binding]; other site 471857005482 tetramer interface [polypeptide binding]; other site 471857005483 dimer interface [polypeptide binding]; other site 471857005484 TPP binding site [chemical binding]; other site 471857005485 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 471857005486 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX...; Region: TPP_POX; cd02014 471857005487 TPP-binding site [chemical binding]; other site 471857005488 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 471857005489 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 471857005490 heme-binding site [chemical binding]; other site 471857005491 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 471857005492 FAD binding pocket [chemical binding]; other site 471857005493 FAD binding motif [chemical binding]; other site 471857005494 phosphate binding motif [ion binding]; other site 471857005495 beta-alpha-beta structure motif; other site 471857005496 NAD binding pocket [chemical binding]; other site 471857005497 Heme binding pocket [chemical binding]; other site 471857005498 Rrf2 family protein; Region: rrf2_super; TIGR00738 471857005499 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857005500 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471857005501 short chain dehydrogenase; Provisional; Region: PRK08251 471857005502 classical (c) SDRs; Region: SDR_c; cd05233 471857005503 NAD(P) binding site [chemical binding]; other site 471857005504 active site 471857005505 hypothetical protein; Provisional; Region: PRK14851 471857005506 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857005507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471857005508 active site 471857005509 phosphorylation site [posttranslational modification] 471857005510 intermolecular recognition site; other site 471857005511 dimerization interface [polypeptide binding]; other site 471857005512 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471857005513 DNA binding residues [nucleotide binding] 471857005514 dimerization interface [polypeptide binding]; other site 471857005515 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 471857005516 Histidine kinase; Region: HisKA_3; pfam07730 471857005517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857005518 ATP binding site [chemical binding]; other site 471857005519 Mg2+ binding site [ion binding]; other site 471857005520 G-X-G motif; other site 471857005521 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471857005522 Ligand Binding Site [chemical binding]; other site 471857005523 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471857005524 Ligand Binding Site [chemical binding]; other site 471857005525 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471857005526 Ligand Binding Site [chemical binding]; other site 471857005527 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 471857005528 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 471857005529 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 471857005530 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 471857005531 active site 471857005532 putative substrate binding region [chemical binding]; other site 471857005533 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471857005534 Ligand Binding Site [chemical binding]; other site 471857005535 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 471857005536 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 471857005537 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 471857005538 putative dimer interface [polypeptide binding]; other site 471857005539 tRNA synthetases class I (C) catalytic domain; Region: tRNA-synt_1e; pfam01406 471857005540 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471857005541 active site 471857005542 HIGH motif; other site 471857005543 nucleotide binding site [chemical binding]; other site 471857005544 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471857005545 active site 471857005546 KMSKS motif; other site 471857005547 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 471857005548 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 471857005549 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 471857005550 TM-ABC transporter signature motif; other site 471857005551 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 471857005552 TM-ABC transporter signature motif; other site 471857005553 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 471857005554 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 471857005555 Walker A/P-loop; other site 471857005556 ATP binding site [chemical binding]; other site 471857005557 Q-loop/lid; other site 471857005558 ABC transporter signature motif; other site 471857005559 Walker B; other site 471857005560 D-loop; other site 471857005561 H-loop/switch region; other site 471857005562 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 471857005563 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 471857005564 Walker A/P-loop; other site 471857005565 ATP binding site [chemical binding]; other site 471857005566 Q-loop/lid; other site 471857005567 ABC transporter signature motif; other site 471857005568 Walker B; other site 471857005569 D-loop; other site 471857005570 H-loop/switch region; other site 471857005571 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 471857005572 Condensation domain; Region: Condensation; cl09290 471857005573 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 471857005574 classical (c) SDRs; Region: SDR_c; cd05233 471857005575 NAD(P) binding site [chemical binding]; other site 471857005576 active site 471857005577 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 471857005578 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 471857005579 FeS/SAM binding site; other site 471857005580 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 471857005581 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 471857005582 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 471857005583 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 471857005584 Active site cavity [active] 471857005585 catalytic acid [active] 471857005586 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 471857005587 substrate binding pocket [chemical binding]; other site 471857005588 chain length determination region; other site 471857005589 substrate-Mg2+ binding site; other site 471857005590 catalytic residues [active] 471857005591 aspartate-rich region 1; other site 471857005592 active site lid residues [active] 471857005593 aspartate-rich region 2; other site 471857005594 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 471857005595 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857005596 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 471857005597 active site lid residues [active] 471857005598 substrate binding pocket [chemical binding]; other site 471857005599 catalytic residues [active] 471857005600 substrate-Mg2+ binding site; other site 471857005601 aspartate-rich region 1; other site 471857005602 aspartate-rich region 2; other site 471857005603 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 471857005604 active site lid residues [active] 471857005605 substrate binding pocket [chemical binding]; other site 471857005606 catalytic residues [active] 471857005607 substrate-Mg2+ binding site; other site 471857005608 aspartate-rich region 1; other site 471857005609 aspartate-rich region 2; other site 471857005610 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471857005611 Ligand Binding Site [chemical binding]; other site 471857005612 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857005613 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471857005614 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 471857005615 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857005616 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857005617 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 471857005618 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471857005619 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 471857005620 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 471857005621 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 471857005622 carboxyltransferase (CT) interaction site; other site 471857005623 biotinylation site [posttranslational modification]; other site 471857005624 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 471857005625 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 471857005626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857005627 putative substrate translocation pore; other site 471857005628 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 471857005629 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 471857005630 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 471857005631 hypothetical protein; Reviewed; Region: PRK09588 471857005632 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 471857005633 GAF domain; Region: GAF; cl00853 471857005634 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471857005635 Histidine kinase; Region: HisKA_3; pfam07730 471857005636 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 471857005637 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 471857005638 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471857005639 tetramerization interface [polypeptide binding]; other site 471857005640 NAD(P) binding site [chemical binding]; other site 471857005641 catalytic residues [active] 471857005642 choline transport protein BetT; Provisional; Region: PRK09928 471857005643 BCCT family transporter; Region: BCCT; cl00569 471857005644 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 471857005645 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 471857005646 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 471857005647 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 471857005648 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471857005649 NAD(P) binding site [chemical binding]; other site 471857005650 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 471857005651 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 471857005652 threonine dehydratase; Validated; Region: PRK08639 471857005653 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 471857005654 tetramer interface [polypeptide binding]; other site 471857005655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857005656 catalytic residue [active] 471857005657 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 471857005658 putative Ile/Val binding site [chemical binding]; other site 471857005659 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 471857005660 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857005661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857005662 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471857005663 putative substrate translocation pore; other site 471857005664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857005665 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 471857005666 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 471857005667 dimer interface [polypeptide binding]; other site 471857005668 motif 1; other site 471857005669 active site 471857005670 motif 2; other site 471857005671 motif 3; other site 471857005672 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 471857005673 anticodon binding site; other site 471857005674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857005675 dimer interface [polypeptide binding]; other site 471857005676 conserved gate region; other site 471857005677 putative PBP binding loops; other site 471857005678 ABC-ATPase subunit interface; other site 471857005679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857005680 dimer interface [polypeptide binding]; other site 471857005681 conserved gate region; other site 471857005682 putative PBP binding loops; other site 471857005683 ABC-ATPase subunit interface; other site 471857005684 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471857005685 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471857005686 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471857005687 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471857005688 DNA binding site [nucleotide binding] 471857005689 domain linker motif; other site 471857005690 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 471857005691 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 471857005692 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 471857005693 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 471857005694 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 471857005695 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258 471857005696 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 471857005697 Walker A/P-loop; other site 471857005698 ATP binding site [chemical binding]; other site 471857005699 Q-loop/lid; other site 471857005700 ABC transporter signature motif; other site 471857005701 Walker B; other site 471857005702 D-loop; other site 471857005703 H-loop/switch region; other site 471857005704 NIL domain; Region: NIL; cl09633 471857005705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 471857005706 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 471857005707 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 471857005708 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 471857005709 oligomeric interface; other site 471857005710 putative active site [active] 471857005711 homodimer interface [polypeptide binding]; other site 471857005712 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 471857005713 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471857005714 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857005715 homodimer interface [polypeptide binding]; other site 471857005716 catalytic residue [active] 471857005717 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 471857005718 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 471857005719 putative active site [active] 471857005720 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 471857005721 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 471857005722 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 471857005723 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857005724 Walker A/P-loop; other site 471857005725 ATP binding site [chemical binding]; other site 471857005726 Q-loop/lid; other site 471857005727 ABC transporter signature motif; other site 471857005728 Walker B; other site 471857005729 D-loop; other site 471857005730 H-loop/switch region; other site 471857005731 CoA-transferase family III; Region: CoA_transf_3; cl00778 471857005732 tetracycline repressor protein TetR; Provisional; Region: PRK13756 471857005733 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857005734 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 471857005735 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471857005736 enoyl-CoA hydratase; Provisional; Region: PRK08252 471857005737 substrate binding site [chemical binding]; other site 471857005738 oxyanion hole (OAH) forming residues; other site 471857005739 trimer interface [polypeptide binding]; other site 471857005740 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471857005741 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471857005742 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471857005743 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471857005744 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857005745 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 471857005746 NAD(P) binding site [chemical binding]; other site 471857005747 active site 471857005748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857005749 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 471857005750 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 471857005751 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857005752 NAD(P) binding site [chemical binding]; other site 471857005753 active site 471857005754 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471857005755 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 471857005756 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857005757 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471857005758 Phage integrase family; Region: Phage_integrase; pfam00589 471857005759 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 471857005760 Int/Topo IB signature motif; other site 471857005761 aconitate hydratase; Validated; Region: PRK07229 471857005762 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 471857005763 substrate binding site [chemical binding]; other site 471857005764 ligand binding site [chemical binding]; other site 471857005765 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 471857005766 substrate binding site [chemical binding]; other site 471857005767 Beta-lactamase; Region: Beta-lactamase; cl01009 471857005768 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 471857005769 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471857005770 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 471857005771 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 471857005772 inhibitor-cofactor binding pocket; inhibition site 471857005773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857005774 catalytic residue [active] 471857005775 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 471857005776 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857005777 Walker A motif; other site 471857005778 ATP binding site [chemical binding]; other site 471857005779 Walker B motif; other site 471857005780 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 471857005781 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 471857005782 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471857005783 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 471857005784 putative catalytic site [active] 471857005785 putative metal binding site [ion binding]; other site 471857005786 putative phosphate binding site [ion binding]; other site 471857005787 acyl-CoA synthetase; Validated; Region: PRK06164 471857005788 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857005789 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 471857005790 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471857005791 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471857005792 active site 471857005793 ATP binding site [chemical binding]; other site 471857005794 substrate binding site [chemical binding]; other site 471857005795 activation loop (A-loop); other site 471857005796 SelR domain; Region: SelR; cl00369 471857005797 Chlorite dismutase; Region: Chlor_dismutase; cl01280 471857005798 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857005799 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717 471857005800 substrate binding site [chemical binding]; other site 471857005801 active site 471857005802 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 471857005803 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 471857005804 putative active site [active] 471857005805 catalytic site [active] 471857005806 putative substrate binding site [chemical binding]; other site 471857005807 HRDC domain; Region: HRDC; cl02578 471857005808 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 471857005809 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 471857005810 dimer interface [polypeptide binding]; other site 471857005811 phosphorylation site [posttranslational modification] 471857005812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857005813 ATP binding site [chemical binding]; other site 471857005814 Mg2+ binding site [ion binding]; other site 471857005815 G-X-G motif; other site 471857005816 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471857005817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471857005818 active site 471857005819 phosphorylation site [posttranslational modification] 471857005820 intermolecular recognition site; other site 471857005821 dimerization interface [polypeptide binding]; other site 471857005822 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 471857005823 DNA binding site [nucleotide binding] 471857005824 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 471857005825 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 471857005826 TPP-binding site; other site 471857005827 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 471857005828 PYR/PP interface [polypeptide binding]; other site 471857005829 dimer interface [polypeptide binding]; other site 471857005830 TPP binding site [chemical binding]; other site 471857005831 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471857005832 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857005833 DNA-binding site [nucleotide binding]; DNA binding site 471857005834 FCD domain; Region: FCD; cl11656 471857005835 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 471857005836 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 471857005837 ATP-binding site [chemical binding]; other site 471857005838 Gluconate-6-phosphate binding site [chemical binding]; other site 471857005839 GntP family permease; Region: GntP_permease; cl15264 471857005840 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 471857005841 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857005842 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857005843 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 471857005844 TRAM domain; Region: TRAM; cl01282 471857005845 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 471857005846 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471857005847 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 471857005848 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 471857005849 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 471857005850 trimer interface [polypeptide binding]; other site 471857005851 active site 471857005852 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 471857005853 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 471857005854 active site 471857005855 dimerization interface [polypeptide binding]; other site 471857005856 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 471857005857 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471857005858 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 471857005859 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857005860 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471857005861 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471857005862 DNA binding residues [nucleotide binding] 471857005863 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 471857005864 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857005865 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471857005866 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 471857005867 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 471857005868 TM-ABC transporter signature motif; other site 471857005869 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 471857005870 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857005871 Walker A/P-loop; other site 471857005872 ATP binding site [chemical binding]; other site 471857005873 Q-loop/lid; other site 471857005874 ABC transporter signature motif; other site 471857005875 Walker B; other site 471857005876 D-loop; other site 471857005877 H-loop/switch region; other site 471857005878 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 471857005879 putative ligand binding site [chemical binding]; other site 471857005880 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471857005881 ATP binding site [chemical binding]; other site 471857005882 putative Mg++ binding site [ion binding]; other site 471857005883 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857005884 ATP-binding site [chemical binding]; other site 471857005885 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 471857005886 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 471857005887 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 471857005888 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 471857005889 substrate binding site [chemical binding]; other site 471857005890 ATP binding site [chemical binding]; other site 471857005891 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 471857005892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471857005893 S-adenosylmethionine binding site [chemical binding]; other site 471857005894 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563 471857005895 putative active site [active] 471857005896 dimerization interface [polypeptide binding]; other site 471857005897 putative tRNAtyr binding site [nucleotide binding]; other site 471857005898 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 471857005899 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 471857005900 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857005901 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471857005902 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471857005903 DNA binding residues [nucleotide binding] 471857005904 fumarate hydratase; Provisional; Region: PRK15389 471857005905 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 471857005906 Fumarase C-terminus; Region: Fumerase_C; cl00795 471857005907 poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938 471857005908 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 471857005909 Protein of unknown function (DUF3607); Region: DUF3607; pfam12245 471857005910 Uncharacterized conserved protein [Function unknown]; Region: COG1306 471857005911 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 471857005912 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471857005913 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 471857005914 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471857005915 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen...; Region: MM_CoA_mut_B12_BD; cd02071 471857005916 B12 binding site [chemical binding]; other site 471857005917 cobalt ligand [ion binding]; other site 471857005918 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 471857005919 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471857005920 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of methylmalonyl-; Region: MM_CoA_mutase; cl00817 471857005921 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 471857005922 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 471857005923 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cd00882 471857005924 G1 box; other site 471857005925 GTP/Mg2+ binding site [chemical binding]; other site 471857005926 G2 box; other site 471857005927 Switch I region; other site 471857005928 G3 box; other site 471857005929 Switch II region; other site 471857005930 G4 box; other site 471857005931 G5 box; other site 471857005932 Protein of unknown function (DUF742); Region: DUF742; pfam05331 471857005933 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 471857005934 Nitrate and nitrite sensing; Region: NIT; pfam08376 471857005935 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 471857005936 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471857005937 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857005938 ATP binding site [chemical binding]; other site 471857005939 Mg2+ binding site [ion binding]; other site 471857005940 G-X-G motif; other site 471857005941 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 471857005942 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 471857005943 dimer interface [polypeptide binding]; other site 471857005944 active site 471857005945 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471857005946 catalytic residues [active] 471857005947 substrate binding site [chemical binding]; other site 471857005948 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 471857005949 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 471857005950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471857005951 S-adenosylmethionine binding site [chemical binding]; other site 471857005952 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 471857005953 Glucitol operon activator protein (GutM); Region: GutM; cl01890 471857005954 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 471857005955 N-acetyl-D-glucosamine binding site [chemical binding]; other site 471857005956 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857005957 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857005958 active site 471857005959 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 471857005960 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857005961 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 471857005962 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471857005963 NAD(P) binding site [chemical binding]; other site 471857005964 catalytic residues [active] 471857005965 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471857005966 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471857005967 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 471857005968 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 471857005969 active site 471857005970 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 471857005971 catalytic triad [active] 471857005972 dimer interface [polypeptide binding]; other site 471857005973 pyruvate kinase; Provisional; Region: PRK06247 471857005974 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 471857005975 domain interfaces; other site 471857005976 active site 471857005977 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 471857005978 transmembrane helices; other site 471857005979 6-phosphofructokinase; Provisional; Region: PRK03202 471857005980 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 471857005981 active site 471857005982 ADP/pyrophosphate binding site [chemical binding]; other site 471857005983 dimerization interface [polypeptide binding]; other site 471857005984 allosteric effector site; other site 471857005985 fructose-1,6-bisphosphate binding site; other site 471857005986 NeuB family; Region: NeuB; cl00496 471857005987 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 471857005988 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471857005989 putative acyl-acceptor binding pocket; other site 471857005990 Esterase/lipase [General function prediction only]; Region: COG1647 471857005991 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 471857005992 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 471857005993 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471857005994 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 471857005995 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471857005996 dimerization interface [polypeptide binding]; other site 471857005997 Metal binding site [ion binding]; metal-binding site 471857005998 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 471857005999 putative hydrophobic ligand binding site [chemical binding]; other site 471857006000 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471857006001 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471857006002 active site 471857006003 metal binding site [ion binding]; metal-binding site 471857006004 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 471857006005 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857006006 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857006007 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857006008 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 471857006009 Walker A/P-loop; other site 471857006010 ATP binding site [chemical binding]; other site 471857006011 Q-loop/lid; other site 471857006012 ABC transporter signature motif; other site 471857006013 Walker B; other site 471857006014 D-loop; other site 471857006015 H-loop/switch region; other site 471857006016 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471857006017 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 471857006018 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 471857006019 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 471857006020 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 471857006021 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471857006022 cell division protein MraZ; Reviewed; Region: PRK00326 471857006023 MraZ protein; Region: MraZ; pfam02381 471857006024 MraZ protein; Region: MraZ; pfam02381 471857006025 MoxR-like ATPases [General function prediction only]; Region: COG0714 471857006026 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471857006027 Walker A motif; other site 471857006028 ATP binding site [chemical binding]; other site 471857006029 Walker B motif; other site 471857006030 arginine finger; other site 471857006031 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 471857006032 Protein of unknown function DUF58; Region: DUF58; pfam01882 471857006033 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 471857006034 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 471857006035 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 471857006036 active site 471857006037 DNA polymerase IV; Validated; Region: PRK02406 471857006038 DNA binding site [nucleotide binding] 471857006039 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471857006040 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 471857006041 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 471857006042 P loop; other site 471857006043 Nucleotide binding site [chemical binding]; other site 471857006044 DTAP/Switch II; other site 471857006045 Switch I; other site 471857006046 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_2_like; cd04738 471857006047 quinone interaction residues [chemical binding]; other site 471857006048 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 471857006049 active site 471857006050 catalytic residues [active] 471857006051 FMN binding site [chemical binding]; other site 471857006052 substrate binding site [chemical binding]; other site 471857006053 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 471857006054 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 471857006055 PspA/IM30 family; Region: PspA_IM30; pfam04012 471857006056 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857006057 non-specific DNA binding site [nucleotide binding]; other site 471857006058 salt bridge; other site 471857006059 sequence-specific DNA binding site [nucleotide binding]; other site 471857006060 Competence-damaged protein; Region: CinA; cl00666 471857006061 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 471857006062 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 471857006063 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 471857006064 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 471857006065 FeS/SAM binding site; other site 471857006066 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 471857006067 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471857006068 Coenzyme A binding pocket [chemical binding]; other site 471857006069 O-succinylbenzoate synthase; Provisional; Region: PRK02901 471857006070 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway...; Region: OSBS; cd03320 471857006071 active site 471857006072 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 471857006073 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857006074 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 471857006075 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 471857006076 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471857006077 putative acyl-acceptor binding pocket; other site 471857006078 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 471857006079 EamA-like transporter family; Region: EamA; cl01037 471857006080 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 471857006081 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471857006082 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 471857006083 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 471857006084 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 471857006085 dimer interface [polypeptide binding]; other site 471857006086 active site 471857006087 catalytic residue [active] 471857006088 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471857006089 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471857006090 active site 471857006091 ATP binding site [chemical binding]; other site 471857006092 substrate binding site [chemical binding]; other site 471857006093 activation loop (A-loop); other site 471857006094 Uncharacterized conserved protein [Function unknown]; Region: COG3603 471857006095 Thymidylate synthase complementing protein; Region: Thy1; cl03630 471857006096 HicB family; Region: HicB; pfam05534 471857006097 Uncharacterized conserved protein [Function unknown]; Region: COG3595 471857006098 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 471857006099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 471857006100 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471857006101 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 471857006102 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 471857006103 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 471857006104 active site 471857006105 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 471857006106 ScpA/B protein; Region: ScpA_ScpB; cl00598 471857006107 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 471857006108 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471857006109 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 471857006110 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471857006111 DNA binding site [nucleotide binding] 471857006112 Int/Topo IB signature motif; other site 471857006113 active site 471857006114 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 471857006115 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 471857006116 TM2 domain; Region: TM2; cl00984 471857006117 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 471857006118 dimer interface [polypeptide binding]; other site 471857006119 active site 471857006120 ADP-ribose binding site [chemical binding]; other site 471857006121 nudix motif; other site 471857006122 metal binding site [ion binding]; metal-binding site 471857006123 CTP synthetase; Validated; Region: pyrG; PRK05380 471857006124 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 471857006125 Catalytic site [active] 471857006126 Active site [active] 471857006127 UTP binding site [chemical binding]; other site 471857006128 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 471857006129 active site 471857006130 putative oxyanion hole; other site 471857006131 catalytic triad [active] 471857006132 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 471857006133 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 471857006134 hinge; other site 471857006135 active site 471857006136 Thiamine pyrophosphokinase; Region: TPK; cl09135 471857006137 DNA repair protein RecN; Region: recN; TIGR00634 471857006138 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 471857006139 Walker A/P-loop; other site 471857006140 ATP binding site [chemical binding]; other site 471857006141 Q-loop/lid; other site 471857006142 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 471857006143 ABC transporter signature motif; other site 471857006144 Walker B; other site 471857006145 D-loop; other site 471857006146 H-loop/switch region; other site 471857006147 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 471857006148 ATP-NAD kinase; Region: NAD_kinase; pfam01513 471857006149 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 471857006150 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 471857006151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471857006152 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 471857006153 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 471857006154 active site 471857006155 motif I; other site 471857006156 motif II; other site 471857006157 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 471857006158 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 471857006159 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 471857006160 active site 471857006161 HIGH motif; other site 471857006162 dimer interface [polypeptide binding]; other site 471857006163 KMSKS motif; other site 471857006164 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 471857006165 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 471857006166 active site 471857006167 DNA binding site [nucleotide binding] 471857006168 argininosuccinate lyase; Provisional; Region: PRK00855 471857006169 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 471857006170 active sites [active] 471857006171 tetramer interface [polypeptide binding]; other site 471857006172 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 471857006173 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 471857006174 ANP binding site [chemical binding]; other site 471857006175 Substrate Binding Site II [chemical binding]; other site 471857006176 Substrate Binding Site I [chemical binding]; other site 471857006177 arginine repressor; Provisional; Region: PRK03341 471857006178 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 471857006179 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 471857006180 ornithine carbamoyltransferase; Provisional; Region: PRK00779 471857006181 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 471857006182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857006183 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 471857006184 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 471857006185 inhibitor-cofactor binding pocket; inhibition site 471857006186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857006187 catalytic residue [active] 471857006188 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using...; Region: AAK_NAGK-C; cd04250 471857006189 feedback inhibition sensing region; other site 471857006190 homohexameric interface [polypeptide binding]; other site 471857006191 nucleotide binding site [chemical binding]; other site 471857006192 N-acetyl-L-glutamate binding site [chemical binding]; other site 471857006193 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152 471857006194 heterotetramer interface [polypeptide binding]; other site 471857006195 active site pocket [active] 471857006196 cleavage site 471857006197 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 471857006198 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857006199 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 471857006200 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 471857006201 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 471857006202 putative tRNA-binding site [nucleotide binding]; other site 471857006203 B3/4 domain; Region: B3_4; cl11458 471857006204 tRNA synthetase B5 domain; Region: B5; cl08394 471857006205 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 471857006206 dimer interface [polypeptide binding]; other site 471857006207 motif 1; other site 471857006208 motif 3; other site 471857006209 motif 2; other site 471857006210 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 471857006211 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 471857006212 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 471857006213 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 471857006214 dimer interface [polypeptide binding]; other site 471857006215 motif 1; other site 471857006216 active site 471857006217 motif 2; other site 471857006218 motif 3; other site 471857006219 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 471857006220 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 471857006221 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 471857006222 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 471857006223 23S rRNA binding site [nucleotide binding]; other site 471857006224 L21 binding site [polypeptide binding]; other site 471857006225 L13 binding site [polypeptide binding]; other site 471857006226 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 471857006227 translation initiation factor IF-3; Region: infC; TIGR00168 471857006228 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 471857006229 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 471857006230 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 471857006231 homotrimer interaction site [polypeptide binding]; other site 471857006232 putative active site [active] 471857006233 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 471857006234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471857006235 active site 471857006236 phosphorylation site [posttranslational modification] 471857006237 intermolecular recognition site; other site 471857006238 dimerization interface [polypeptide binding]; other site 471857006239 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 471857006240 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857006241 Mg2+ binding site [ion binding]; other site 471857006242 G-X-G motif; other site 471857006243 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 471857006244 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 471857006245 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 471857006246 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 471857006247 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 471857006248 Acyltransferase family; Region: Acyl_transf_3; pfam01757 471857006249 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 471857006250 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471857006251 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 471857006252 nudix motif; other site 471857006253 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471857006254 L-arabinose isomerase; Provisional; Region: PRK02929 471857006255 RES domain; Region: RES; cl02411 471857006256 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 471857006257 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471857006258 Integral membrane protein TerC family; Region: TerC; cl10468 471857006259 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 471857006260 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471857006261 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 471857006262 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471857006263 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 471857006264 Walker A/P-loop; other site 471857006265 ATP binding site [chemical binding]; other site 471857006266 Q-loop/lid; other site 471857006267 ABC transporter signature motif; other site 471857006268 Walker B; other site 471857006269 D-loop; other site 471857006270 H-loop/switch region; other site 471857006271 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 471857006272 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 471857006273 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 471857006274 excinuclease ABC subunit B; Provisional; Region: PRK05298 471857006275 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857006276 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857006277 nucleotide binding region [chemical binding]; other site 471857006278 ATP-binding site [chemical binding]; other site 471857006279 Ultra-violet resistance protein B; Region: UvrB; pfam12344 471857006280 UvrB/uvrC motif; Region: UVR; pfam02151 471857006281 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 471857006282 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471857006283 dimerization interface [polypeptide binding]; other site 471857006284 putative DNA binding site [nucleotide binding]; other site 471857006285 putative Zn2+ binding site [ion binding]; other site 471857006286 Protein of unknown function (DUF402); Region: DUF402; cl00979 471857006287 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 471857006288 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 471857006289 CoA-binding site [chemical binding]; other site 471857006290 ATP-binding [chemical binding]; other site 471857006291 Uncharacterised protein family (UPF0157); Region: UPF0157; cl00987 471857006292 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 471857006293 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 471857006294 RNA binding site [nucleotide binding]; other site 471857006295 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 471857006296 RNA binding site [nucleotide binding]; other site 471857006297 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 471857006298 RNA binding site [nucleotide binding]; other site 471857006299 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 471857006300 RNA binding site [nucleotide binding]; other site 471857006301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471857006302 S-adenosylmethionine binding site [chemical binding]; other site 471857006303 short chain dehydrogenase; Provisional; Region: PRK08309 471857006304 DNA polymerase I; Provisional; Region: PRK05755 471857006305 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 471857006306 active site 471857006307 metal binding site 1 [ion binding]; metal-binding site 471857006308 putative 5' ssDNA interaction site; other site 471857006309 metal binding site 3; metal-binding site 471857006310 metal binding site 2 [ion binding]; metal-binding site 471857006311 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 471857006312 putative DNA binding site [nucleotide binding]; other site 471857006313 putative metal binding site [ion binding]; other site 471857006314 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 471857006315 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 471857006316 active site 471857006317 DNA binding site [nucleotide binding] 471857006318 catalytic site [active] 471857006319 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 471857006320 CoenzymeA binding site [chemical binding]; other site 471857006321 subunit interaction site [polypeptide binding]; other site 471857006322 PHB binding site; other site 471857006323 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 471857006324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471857006325 active site 471857006326 phosphorylation site [posttranslational modification] 471857006327 intermolecular recognition site; other site 471857006328 dimerization interface [polypeptide binding]; other site 471857006329 ANTAR domain; Region: ANTAR; cl04297 471857006330 glycoside hydrolase family 64: beta-1,3-glucanase B (GluB)-like; Region: GH64-GluB-like; cd09220 471857006331 substrate binding pocket [chemical binding]; other site 471857006332 catalytic residues [active] 471857006333 benzoate transport; Region: 2A0115; TIGR00895 471857006334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857006335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857006336 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 471857006337 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-...; Region: PDR_like; cd06185 471857006338 FMN-binding pocket [chemical binding]; other site 471857006339 flavin binding motif; other site 471857006340 phosphate binding motif [ion binding]; other site 471857006341 beta-alpha-beta structure motif; other site 471857006342 NAD binding pocket [chemical binding]; other site 471857006343 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471857006344 catalytic loop [active] 471857006345 iron binding site [ion binding]; other site 471857006346 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 471857006347 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 471857006348 iron-sulfur cluster [ion binding]; other site 471857006349 [2Fe-2S] cluster binding site [ion binding]; other site 471857006350 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 471857006351 alpha subunit interface [polypeptide binding]; other site 471857006352 active site 471857006353 substrate binding site [chemical binding]; other site 471857006354 Fe binding site [ion binding]; other site 471857006355 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857006356 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471857006357 Coenzyme A binding pocket [chemical binding]; other site 471857006358 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 471857006359 active site 471857006360 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 471857006361 dimer interface [polypeptide binding]; other site 471857006362 non-prolyl cis peptide bond; other site 471857006363 insertion regions; other site 471857006364 Flavin Reductases; Region: FlaRed; cl00801 471857006365 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 471857006366 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471857006367 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471857006368 NAD(P) binding site [chemical binding]; other site 471857006369 catalytic residues [active] 471857006370 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471857006371 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471857006372 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 471857006373 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 471857006374 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857006375 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 471857006376 dimerization interface [polypeptide binding]; other site 471857006377 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 471857006378 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 471857006379 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 471857006380 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 471857006381 Walker A/P-loop; other site 471857006382 ATP binding site [chemical binding]; other site 471857006383 Q-loop/lid; other site 471857006384 ABC transporter signature motif; other site 471857006385 Walker B; other site 471857006386 D-loop; other site 471857006387 H-loop/switch region; other site 471857006388 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cd02205 471857006389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857006390 dimer interface [polypeptide binding]; other site 471857006391 conserved gate region; other site 471857006392 ABC-ATPase subunit interface; other site 471857006393 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471857006394 Sulfatase; Region: Sulfatase; cl10460 471857006395 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 471857006396 Domain of unknown function DUF; Region: DUF202; cl09954 471857006397 Domain of unknown function DUF; Region: DUF202; cl09954 471857006398 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 471857006399 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857006400 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 471857006401 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 471857006402 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 471857006403 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 471857006404 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857006405 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 471857006406 dimerization interface [polypeptide binding]; other site 471857006407 substrate binding pocket [chemical binding]; other site 471857006408 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857006409 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857006410 active site 471857006411 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471857006412 anti sigma factor interaction site; other site 471857006413 regulatory phosphorylation site [posttranslational modification]; other site 471857006414 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 471857006415 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 471857006416 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857006417 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 471857006418 active site lid residues [active] 471857006419 substrate binding pocket [chemical binding]; other site 471857006420 catalytic residues [active] 471857006421 substrate-Mg2+ binding site; other site 471857006422 aspartate-rich region 1; other site 471857006423 aspartate-rich region 2; other site 471857006424 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 471857006425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471857006426 Uncharacterized conserved protein [Function unknown]; Region: COG3349 471857006427 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857006428 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 471857006429 iron-sulfur cluster [ion binding]; other site 471857006430 [2Fe-2S] cluster binding site [ion binding]; other site 471857006431 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471857006432 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857006433 Walker A/P-loop; other site 471857006434 ATP binding site [chemical binding]; other site 471857006435 Q-loop/lid; other site 471857006436 ABC transporter signature motif; other site 471857006437 Walker B; other site 471857006438 D-loop; other site 471857006439 H-loop/switch region; other site 471857006440 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 471857006441 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 471857006442 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-...; Region: PA_degradation_oxidoreductase_like; cd06214 471857006443 FAD binding pocket [chemical binding]; other site 471857006444 FAD binding motif [chemical binding]; other site 471857006445 phosphate binding motif [ion binding]; other site 471857006446 beta-alpha-beta structure motif; other site 471857006447 NAD(p) ribose binding residues [chemical binding]; other site 471857006448 NAD binding pocket [chemical binding]; other site 471857006449 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 471857006450 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471857006451 catalytic loop [active] 471857006452 iron binding site [ion binding]; other site 471857006453 Domain of unknown function DUF59; Region: DUF59; cl00941 471857006454 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 471857006455 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 471857006456 Phenylacetic acid degradation B; Region: PaaB; cl01371 471857006457 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 471857006458 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 471857006459 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 471857006460 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 471857006461 substrate binding site [chemical binding]; other site 471857006462 dimer interface [polypeptide binding]; other site 471857006463 NADP binding site [chemical binding]; other site 471857006464 catalytic residues [active] 471857006465 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 471857006466 active site 2 [active] 471857006467 active site 1 [active] 471857006468 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260 471857006469 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 471857006470 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471857006471 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 471857006472 CoenzymeA binding site [chemical binding]; other site 471857006473 subunit interaction site [polypeptide binding]; other site 471857006474 PHB binding site; other site 471857006475 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857006476 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857006477 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857006478 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857006479 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 471857006480 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 471857006481 Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755 471857006482 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471857006483 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857006484 Bacterial transcriptional regulator; Region: IclR; pfam01614 471857006485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857006486 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 471857006487 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857006488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857006489 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471857006490 putative substrate translocation pore; other site 471857006491 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 471857006492 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857006493 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 471857006494 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471857006495 substrate binding site [chemical binding]; other site 471857006496 oxyanion hole (OAH) forming residues; other site 471857006497 trimer interface [polypeptide binding]; other site 471857006498 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857006499 sequence-specific DNA binding site [nucleotide binding]; other site 471857006500 salt bridge; other site 471857006501 hypothetical protein; Provisional; Region: PRK07588 471857006502 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857006503 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857006504 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857006505 Domain of unknown function (DUF1994); Region: DUF1994; pfam09352 471857006506 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 471857006507 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 471857006508 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857006509 Walker A/P-loop; other site 471857006510 ATP binding site [chemical binding]; other site 471857006511 Q-loop/lid; other site 471857006512 ABC transporter signature motif; other site 471857006513 Walker B; other site 471857006514 D-loop; other site 471857006515 H-loop/switch region; other site 471857006516 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857006517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471857006518 active site 471857006519 phosphorylation site [posttranslational modification] 471857006520 intermolecular recognition site; other site 471857006521 dimerization interface [polypeptide binding]; other site 471857006522 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471857006523 DNA binding residues [nucleotide binding] 471857006524 dimerization interface [polypeptide binding]; other site 471857006525 Histidine kinase; Region: HisKA_3; pfam07730 471857006526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471857006527 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471857006528 CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918 471857006529 ligand binding site [chemical binding]; other site 471857006530 flexible hinge region; other site 471857006531 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857006532 Gammaherpesvirus latent membrane protein (LMP2) protein; Region: Herpes_LMP2; pfam07415 471857006533 Endonuclease I; Region: Endonuclease_1; cl01003 471857006534 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 471857006535 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 471857006536 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 471857006537 DXD motif; other site 471857006538 Acyltransferase family; Region: Acyl_transf_3; pfam01757 471857006539 K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927 471857006540 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 471857006541 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 471857006542 NAD binding site [chemical binding]; other site 471857006543 catalytic Zn binding site [ion binding]; other site 471857006544 structural Zn binding site [ion binding]; other site 471857006545 Cytochrome P450; Region: p450; cl12078 471857006546 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 471857006547 THUMP domain; Region: THUMP; cl12076 471857006548 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 471857006549 Ligand Binding Site [chemical binding]; other site 471857006550 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 471857006551 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 471857006552 FAD binding site [chemical binding]; other site 471857006553 Adenosylhomocysteinase; Provisional; Region: PTZ00075 471857006554 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado...; Region: AdoHcyase; cd00401 471857006555 oligomerization interface [polypeptide binding]; other site 471857006556 active site 471857006557 NAD+ binding site [chemical binding]; other site 471857006558 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 471857006559 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 471857006560 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 471857006561 substrate binding pocket [chemical binding]; other site 471857006562 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 471857006563 B12 binding site [chemical binding]; other site 471857006564 cobalt ligand [ion binding]; other site 471857006565 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 471857006566 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 471857006567 substrate binding site [chemical binding]; other site 471857006568 ATP binding site [chemical binding]; other site 471857006569 S-adenosylmethionine synthetase; Validated; Region: PRK05250 471857006570 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 471857006571 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 471857006572 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 471857006573 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 471857006574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471857006575 S-adenosylmethionine binding site [chemical binding]; other site 471857006576 tocopherol O-methyltransferase; Region: PLN02244 471857006577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471857006578 S-adenosylmethionine binding site [chemical binding]; other site 471857006579 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471857006580 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857006581 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471857006582 Bacterial transcriptional regulator; Region: IclR; pfam01614 471857006583 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857006584 DNA-binding site [nucleotide binding]; DNA binding site 471857006585 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 471857006586 CGNR zinc finger; Region: zf-CGNR; pfam11706 471857006587 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471857006588 anti sigma factor interaction site; other site 471857006589 regulatory phosphorylation site [posttranslational modification]; other site 471857006590 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 471857006591 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857006592 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471857006593 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471857006594 DNA binding residues [nucleotide binding] 471857006595 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 471857006596 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471857006597 catalytic loop [active] 471857006598 iron binding site [ion binding]; other site 471857006599 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 471857006600 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 471857006601 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 471857006602 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 471857006603 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 471857006604 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 471857006605 short chain dehydrogenase; Provisional; Region: PRK06701 471857006606 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857006607 NAD(P) binding site [chemical binding]; other site 471857006608 active site 471857006609 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 471857006610 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 471857006611 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 471857006612 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 471857006613 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 471857006614 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 471857006615 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 471857006616 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 471857006617 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 471857006618 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14959 471857006619 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 471857006620 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 471857006621 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 471857006622 active site 471857006623 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 471857006624 Uncharacterised ACR, YggU family COG1872; Region: DUF167; cl00811 471857006625 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 471857006626 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 471857006627 HIGH motif; other site 471857006628 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 471857006629 active site 471857006630 KMSKS motif; other site 471857006631 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 471857006632 tRNA binding surface [nucleotide binding]; other site 471857006633 anticodon binding site; other site 471857006634 DivIVA protein; Region: DivIVA; pfam05103 471857006635 DivIVA domain; Region: DivI1A_domain; TIGR03544 471857006636 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 471857006637 Protein of unknown function (DUF552); Region: DUF552; cl00775 471857006638 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 471857006639 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471857006640 catalytic residue [active] 471857006641 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 471857006642 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 471857006643 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 471857006644 nucleotide binding site [chemical binding]; other site 471857006645 SulA interaction site; other site 471857006646 DinB superfamily; Region: DinB_2; cl00986 471857006647 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 471857006648 Cell division protein FtsQ; Region: FtsQ; pfam03799 471857006649 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 471857006650 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471857006651 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471857006652 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471857006653 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 471857006654 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 471857006655 homodimer interface [polypeptide binding]; other site 471857006656 active site 471857006657 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 471857006658 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 471857006659 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471857006660 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471857006661 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 471857006662 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 471857006663 Mg++ binding site [ion binding]; other site 471857006664 putative catalytic motif [active] 471857006665 putative substrate binding site [chemical binding]; other site 471857006666 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 471857006667 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471857006668 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471857006669 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471857006670 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 471857006671 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471857006672 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471857006673 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471857006674 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 471857006675 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857006676 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 471857006677 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 471857006678 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 471857006679 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 471857006680 active site residue [active] 471857006681 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 471857006682 active site residue [active] 471857006683 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857006684 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 471857006685 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 471857006686 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 471857006687 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 471857006688 NAD binding site [chemical binding]; other site 471857006689 homodimer interface [polypeptide binding]; other site 471857006690 active site 471857006691 substrate binding site [chemical binding]; other site 471857006692 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 471857006693 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471857006694 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 471857006695 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 471857006696 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471857006697 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857006698 NAD(P) binding site [chemical binding]; other site 471857006699 active site 471857006700 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 471857006701 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 471857006702 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 471857006703 active site 471857006704 dimer interface [polypeptide binding]; other site 471857006705 effector binding site; other site 471857006706 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 471857006707 TSCPD domain; Region: TSCPD; cl14834 471857006708 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 471857006709 ATP cone domain; Region: ATP-cone; pfam03477 471857006710 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857006711 LexA repressor; Validated; Region: PRK00215 471857006712 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 471857006713 Catalytic site [active] 471857006714 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 471857006715 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 471857006716 G1 box; other site 471857006717 GTP/Mg2+ binding site [chemical binding]; other site 471857006718 Switch I region; other site 471857006719 G2 box; other site 471857006720 G3 box; other site 471857006721 Switch II region; other site 471857006722 G4 box; other site 471857006723 G5 box; other site 471857006724 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471857006725 dimerization interface [polypeptide binding]; other site 471857006726 putative DNA binding site [nucleotide binding]; other site 471857006727 putative Zn2+ binding site [ion binding]; other site 471857006728 H+ Antiporter protein; Region: 2A0121; TIGR00900 471857006729 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 471857006730 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 471857006731 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 471857006732 IPP transferase; Region: IPPT; cl00403 471857006733 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 471857006734 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 471857006735 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 471857006736 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 471857006737 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 471857006738 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 471857006739 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 471857006740 FeS/SAM binding site; other site 471857006741 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 471857006742 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 471857006743 Walker A/P-loop; other site 471857006744 ATP binding site [chemical binding]; other site 471857006745 Q-loop/lid; other site 471857006746 ABC transporter signature motif; other site 471857006747 Walker B; other site 471857006748 D-loop; other site 471857006749 H-loop/switch region; other site 471857006750 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 471857006751 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 471857006752 substrate binding pocket [chemical binding]; other site 471857006753 membrane-bound complex binding site; other site 471857006754 hinge residues; other site 471857006755 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857006756 dimer interface [polypeptide binding]; other site 471857006757 conserved gate region; other site 471857006758 putative PBP binding loops; other site 471857006759 ABC-ATPase subunit interface; other site 471857006760 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 471857006761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857006762 dimer interface [polypeptide binding]; other site 471857006763 conserved gate region; other site 471857006764 putative PBP binding loops; other site 471857006765 ABC-ATPase subunit interface; other site 471857006766 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 471857006767 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 471857006768 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857006769 domain; Region: Succ_DH_flav_C; pfam02910 471857006770 Dehydratase family; Region: ILVD_EDD; cl00340 471857006771 6-phosphogluconate dehydratase; Region: edd; TIGR01196 471857006772 Entner-Doudoroff aldolase; Region: eda; TIGR01182 471857006773 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 471857006774 active site 471857006775 intersubunit interface [polypeptide binding]; other site 471857006776 catalytic residue [active] 471857006777 Protein of unknown function (DUF1222); Region: DUF1222; pfam06762 471857006778 RecX family; Region: RecX; cl00936 471857006779 recombinase A; Provisional; Region: recA; PRK09354 471857006780 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 471857006781 hexamer interface [polypeptide binding]; other site 471857006782 Walker A motif; other site 471857006783 ATP binding site [chemical binding]; other site 471857006784 Walker B motif; other site 471857006785 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 471857006786 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 471857006787 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471857006788 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 471857006789 ATP binding site [chemical binding]; other site 471857006790 putative Mg++ binding site [ion binding]; other site 471857006791 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857006792 nucleotide binding region [chemical binding]; other site 471857006793 ATP-binding site [chemical binding]; other site 471857006794 DEAD/H associated; Region: DEAD_assoc; pfam08494 471857006795 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 471857006796 active site 471857006797 catalytic residues [active] 471857006798 metal binding site [ion binding]; metal-binding site 471857006799 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 471857006800 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 471857006801 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 471857006802 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 471857006803 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 471857006804 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 471857006805 substrate binding pocket [chemical binding]; other site 471857006806 chain length determination region; other site 471857006807 substrate-Mg2+ binding site; other site 471857006808 catalytic residues [active] 471857006809 aspartate-rich region 1; other site 471857006810 active site lid residues [active] 471857006811 aspartate-rich region 2; other site 471857006812 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471857006813 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 471857006814 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471857006815 Walker A motif; other site 471857006816 ATP binding site [chemical binding]; other site 471857006817 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 471857006818 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471857006819 DNA binding residues [nucleotide binding] 471857006820 dimerization interface [polypeptide binding]; other site 471857006821 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 471857006822 isoform II; Region: PAF-AH_p_II; pfam03403 471857006823 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471857006824 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471857006825 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471857006826 active site 471857006827 ATP binding site [chemical binding]; other site 471857006828 substrate binding site [chemical binding]; other site 471857006829 activation loop (A-loop); other site 471857006830 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 471857006831 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 471857006832 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 471857006833 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 471857006834 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 471857006835 Condensation domain; Region: Condensation; cl09290 471857006836 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 471857006837 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 471857006838 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 471857006839 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857006840 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 471857006841 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713 471857006842 active site 471857006843 dimer interface [polypeptide binding]; other site 471857006844 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 471857006845 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 471857006846 active site 471857006847 FMN binding site [chemical binding]; other site 471857006848 substrate binding site [chemical binding]; other site 471857006849 3Fe-4S cluster binding site [ion binding]; other site 471857006850 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 471857006851 domain interface; other site 471857006852 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 471857006853 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 471857006854 putative binding site residues; other site 471857006855 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 471857006856 ABC-ATPase subunit interface; other site 471857006857 dimer interface [polypeptide binding]; other site 471857006858 putative PBP binding regions; other site 471857006859 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 471857006860 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 471857006861 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 471857006862 tryptophan synthase; Region: PLN02591 471857006863 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 471857006864 substrate binding site [chemical binding]; other site 471857006865 active site 471857006866 catalytic residues [active] 471857006867 heterodimer interface [polypeptide binding]; other site 471857006868 tryptophan synthase, beta chain; Region: PLN02618 471857006869 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 471857006870 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857006871 catalytic residue [active] 471857006872 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 471857006873 active site 471857006874 ribulose/triose binding site [chemical binding]; other site 471857006875 phosphate binding site [ion binding]; other site 471857006876 substrate (anthranilate) binding pocket [chemical binding]; other site 471857006877 product (indole) binding pocket [chemical binding]; other site 471857006878 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl09759 471857006879 anthranilate synthase component I; Provisional; Region: PRK13571 471857006880 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 471857006881 chorismate binding enzyme; Region: Chorismate_bind; cl10555 471857006882 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857006883 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857006884 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 471857006885 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 471857006886 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 471857006887 substrate binding site [chemical binding]; other site 471857006888 glutamase interaction surface [polypeptide binding]; other site 471857006889 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471857006890 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 471857006891 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 471857006892 catalytic residues [active] 471857006893 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 471857006894 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 471857006895 putative active site [active] 471857006896 oxyanion strand; other site 471857006897 catalytic triad [active] 471857006898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 471857006899 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 471857006900 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 471857006901 VanW like protein; Region: VanW; pfam04294 471857006902 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 471857006903 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 471857006904 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 471857006905 NAD binding site [chemical binding]; other site 471857006906 Phe binding site; other site 471857006907 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471857006908 substrate binding site [chemical binding]; other site 471857006909 oxyanion hole (OAH) forming residues; other site 471857006910 trimer interface [polypeptide binding]; other site 471857006911 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 471857006912 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 471857006913 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 471857006914 Electron transfer flavoprotein, beta subunit [Energy production and conversion]; Region: FixA; COG2086 471857006915 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 471857006916 Ligand binding site [chemical binding]; other site 471857006917 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 471857006918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471857006919 S-adenosylmethionine binding site [chemical binding]; other site 471857006920 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 471857006921 Uncharacterized conserved protein [Function unknown]; Region: COG1543 471857006922 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 471857006923 beta-D-glucuronidase; Provisional; Region: PRK10150 471857006924 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 471857006925 domain; Region: Glyco_hydro_2; pfam00703 471857006926 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 471857006927 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471857006928 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 471857006929 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 471857006930 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857006931 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857006932 malate synthase A; Region: malate_syn_A; TIGR01344 471857006933 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 471857006934 active site 471857006935 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 471857006936 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 471857006937 tetramer interface [polypeptide binding]; other site 471857006938 active site 471857006939 Mg2+/Mn2+ binding site [ion binding]; other site 471857006940 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857006941 non-specific DNA binding site [nucleotide binding]; other site 471857006942 salt bridge; other site 471857006943 sequence-specific DNA binding site [nucleotide binding]; other site 471857006944 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 471857006945 Domain of unknown function (DUF955); Region: DUF955; cl01076 471857006946 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 471857006947 Peptidase M14-like domain of a functionally uncharacterized subgroup of the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains...; Region: Peptidase_M14-like_1_2; cd06239 471857006948 putative active site [active] 471857006949 Zn-binding site [ion binding]; other site 471857006950 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 471857006951 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-...; Region: LbH_MAT_like; cd04647 471857006952 trimer interface [polypeptide binding]; other site 471857006953 active site 471857006954 substrate binding site [chemical binding]; other site 471857006955 CoA binding site [chemical binding]; other site 471857006956 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 471857006957 active site 471857006958 tetramer interface [polypeptide binding]; other site 471857006959 NlpC/P60 family; Region: NLPC_P60; cl11438 471857006960 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857006961 Walker A/P-loop; other site 471857006962 ATP binding site [chemical binding]; other site 471857006963 Q-loop/lid; other site 471857006964 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 471857006965 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857006966 Walker A/P-loop; other site 471857006967 ATP binding site [chemical binding]; other site 471857006968 Q-loop/lid; other site 471857006969 ABC transporter signature motif; other site 471857006970 Walker B; other site 471857006971 D-loop; other site 471857006972 H-loop/switch region; other site 471857006973 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 471857006974 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471857006975 S-adenosylmethionine binding site [chemical binding]; other site 471857006976 enoyl-CoA hydratase; Provisional; Region: PRK08138 471857006977 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471857006978 substrate binding site [chemical binding]; other site 471857006979 oxyanion hole (OAH) forming residues; other site 471857006980 trimer interface [polypeptide binding]; other site 471857006981 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 471857006982 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857006983 Walker A/P-loop; other site 471857006984 ATP binding site [chemical binding]; other site 471857006985 Q-loop/lid; other site 471857006986 ABC transporter signature motif; other site 471857006987 Walker B; other site 471857006988 D-loop; other site 471857006989 H-loop/switch region; other site 471857006990 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 471857006991 putative homodimer interface [polypeptide binding]; other site 471857006992 putative active site pocket [active] 471857006993 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 471857006994 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 471857006995 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 471857006996 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 471857006997 Domain of unknown function DUF77; Region: DUF77; cl00307 471857006998 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471857006999 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857007000 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 471857007001 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 471857007002 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 471857007003 putative acyltransferase; Provisional; Region: PRK05790 471857007004 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471857007005 dimer interface [polypeptide binding]; other site 471857007006 active site 471857007007 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 471857007008 dimer interface [polypeptide binding]; other site 471857007009 substrate binding site [chemical binding]; other site 471857007010 metal binding site [ion binding]; metal-binding site 471857007011 DivIVA protein; Region: DivIVA; pfam05103 471857007012 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471857007013 Ligand Binding Site [chemical binding]; other site 471857007014 cyclase homology domain; Region: CHD; cd07302 471857007015 nucleotidyl binding site; other site 471857007016 metal binding site [ion binding]; metal-binding site 471857007017 dimer interface [polypeptide binding]; other site 471857007018 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 471857007019 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 471857007020 ATP binding site [chemical binding]; other site 471857007021 Mg++ binding site [ion binding]; other site 471857007022 motif III; other site 471857007023 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857007024 nucleotide binding region [chemical binding]; other site 471857007025 ATP-binding site [chemical binding]; other site 471857007026 DbpA RNA binding domain; Region: DbpA; pfam03880 471857007027 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471857007028 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 471857007029 NAD(P) binding site [chemical binding]; other site 471857007030 catalytic residues [active] 471857007031 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 471857007032 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471857007033 S-adenosylmethionine binding site [chemical binding]; other site 471857007034 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 471857007035 putative active site [active] 471857007036 putative substrate binding site [chemical binding]; other site 471857007037 catalytic site [active] 471857007038 dimer interface [polypeptide binding]; other site 471857007039 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 471857007040 substrate binding site [chemical binding]; other site 471857007041 dimer interface [polypeptide binding]; other site 471857007042 catalytic triad [active] 471857007043 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 471857007044 dihydroxyacetone kinase; Provisional; Region: PRK14479 471857007045 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 471857007046 DAK2 domain; Region: Dak2; cl03685 471857007047 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 471857007048 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857007049 DNA-binding site [nucleotide binding]; DNA binding site 471857007050 FCD domain; Region: FCD; cl11656 471857007051 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471857007052 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471857007053 classical (c) SDRs; Region: SDR_c; cd05233 471857007054 NAD(P) binding site [chemical binding]; other site 471857007055 active site 471857007056 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 471857007057 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 471857007058 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471857007059 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 471857007060 GntP family permease; Region: GntP_permease; cl15264 471857007061 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 471857007062 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 471857007063 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471857007064 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857007065 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857007066 active site 471857007067 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 471857007068 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 471857007069 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 471857007070 catalytic Zn binding site [ion binding]; other site 471857007071 NAD binding site [chemical binding]; other site 471857007072 structural Zn binding site [ion binding]; other site 471857007073 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 471857007074 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 471857007075 FMN binding site [chemical binding]; other site 471857007076 substrate binding site [chemical binding]; other site 471857007077 putative catalytic residue [active] 471857007078 PspC domain; Region: PspC; cl00864 471857007079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471857007080 S-adenosylmethionine binding site [chemical binding]; other site 471857007081 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 471857007082 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857007083 H+ Antiporter protein; Region: 2A0121; TIGR00900 471857007084 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 471857007085 metal binding site [ion binding]; metal-binding site 471857007086 active site 471857007087 I-site; other site 471857007088 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 471857007089 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 471857007090 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471857007091 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 471857007092 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857007093 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857007094 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 471857007095 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857007096 non-specific DNA binding site [nucleotide binding]; other site 471857007097 salt bridge; other site 471857007098 sequence-specific DNA binding site [nucleotide binding]; other site 471857007099 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 471857007100 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 471857007101 active site 471857007102 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 471857007103 DNA-binding site [nucleotide binding]; DNA binding site 471857007104 RNA-binding motif; other site 471857007105 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 471857007106 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 471857007107 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 471857007108 catalytic triad [active] 471857007109 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 471857007110 active site 471857007111 dimerization interface [polypeptide binding]; other site 471857007112 ribonuclease PH; Reviewed; Region: rph; PRK00173 471857007113 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 471857007114 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 471857007115 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 471857007116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471857007117 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471857007118 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 471857007119 Rhomboid family; Region: Rhomboid; cl11446 471857007120 cysteine synthases; Region: cysKM; TIGR01136 471857007121 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 471857007122 dimer interface [polypeptide binding]; other site 471857007123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857007124 catalytic residue [active] 471857007125 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 471857007126 MoaE interaction surface [polypeptide binding]; other site 471857007127 MoeB interaction surface [polypeptide binding]; other site 471857007128 thiocarboxylated glycine; other site 471857007129 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 471857007130 MPN+ (JAMM) motif; other site 471857007131 Zinc-binding site [ion binding]; other site 471857007132 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 471857007133 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-; Region: nylC_like; cd02252 471857007134 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-; Region: nylC_like; cd02252 471857007135 cleavage site 471857007136 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 471857007137 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 471857007138 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 471857007139 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_A; cd01570 471857007140 active site 471857007141 Isochorismatase family; Region: Isochorismatase; pfam00857 471857007142 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 471857007143 catalytic triad [active] 471857007144 metal binding site [ion binding]; metal-binding site 471857007145 conserved cis-peptide bond; other site 471857007146 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 471857007147 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 471857007148 substrate binding site [chemical binding]; other site 471857007149 ATP binding site [chemical binding]; other site 471857007150 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 471857007151 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857007152 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857007153 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 471857007154 dimer interface [polypeptide binding]; other site 471857007155 putative active site [active] 471857007156 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 471857007157 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 471857007158 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 471857007159 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 471857007160 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 471857007161 motif II; other site 471857007162 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 471857007163 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 471857007164 D-pathway; other site 471857007165 Putative ubiquinol binding site [chemical binding]; other site 471857007166 Low-spin heme (heme b) binding site [chemical binding]; other site 471857007167 Putative water exit pathway; other site 471857007168 Binuclear center (heme o3/CuB) [ion binding]; other site 471857007169 K-pathway; other site 471857007170 Putative proton exit pathway; other site 471857007171 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471857007172 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 471857007173 Sulfatase; Region: Sulfatase; cl10460 471857007174 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 471857007175 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cl00025 471857007176 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 471857007177 dimerization domain swap beta strand [polypeptide binding]; other site 471857007178 regulatory protein interface [polypeptide binding]; other site 471857007179 active site 471857007180 regulatory phosphorylation site [posttranslational modification]; other site 471857007181 DAK2 domain; Region: Dak2; cl03685 471857007182 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 471857007183 Dak1 domain; Region: Dak1; pfam02733 471857007184 Protein of unknown function DUF91; Region: DUF91; cl00709 471857007185 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 471857007186 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857007187 dimer interface [polypeptide binding]; other site 471857007188 conserved gate region; other site 471857007189 putative PBP binding loops; other site 471857007190 ABC-ATPase subunit interface; other site 471857007191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857007192 dimer interface [polypeptide binding]; other site 471857007193 conserved gate region; other site 471857007194 putative PBP binding loops; other site 471857007195 ABC-ATPase subunit interface; other site 471857007196 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 471857007197 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 471857007198 substrate binding pocket [chemical binding]; other site 471857007199 membrane-bound complex binding site; other site 471857007200 hinge residues; other site 471857007201 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 471857007202 dimer interface [polypeptide binding]; other site 471857007203 ADP-ribose binding site [chemical binding]; other site 471857007204 active site 471857007205 nudix motif; other site 471857007206 metal binding site [ion binding]; metal-binding site 471857007207 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471857007208 enoyl-CoA hydratase; Validated; Region: PRK08139 471857007209 substrate binding site [chemical binding]; other site 471857007210 oxyanion hole (OAH) forming residues; other site 471857007211 trimer interface [polypeptide binding]; other site 471857007212 ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005 471857007213 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 471857007214 Walker A/P-loop; other site 471857007215 ATP binding site [chemical binding]; other site 471857007216 Q-loop/lid; other site 471857007217 ABC transporter signature motif; other site 471857007218 Walker B; other site 471857007219 D-loop; other site 471857007220 H-loop/switch region; other site 471857007221 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 471857007222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857007223 dimer interface [polypeptide binding]; other site 471857007224 conserved gate region; other site 471857007225 putative PBP binding loops; other site 471857007226 ABC-ATPase subunit interface; other site 471857007227 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 471857007228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857007229 dimer interface [polypeptide binding]; other site 471857007230 conserved gate region; other site 471857007231 putative PBP binding loops; other site 471857007232 ABC-ATPase subunit interface; other site 471857007233 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 471857007234 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 471857007235 substrate binding pocket [chemical binding]; other site 471857007236 membrane-bound complex binding site; other site 471857007237 hinge residues; other site 471857007238 LysE type translocator; Region: LysE; cl00565 471857007239 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 471857007240 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 471857007241 hinge; other site 471857007242 active site 471857007243 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 471857007244 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 471857007245 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 471857007246 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 471857007247 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 471857007248 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 471857007249 alpha subunit interaction interface [polypeptide binding]; other site 471857007250 Walker A motif; other site 471857007251 ATP binding site [chemical binding]; other site 471857007252 Walker B motif; other site 471857007253 inhibitor binding site; inhibition site 471857007254 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 471857007255 ATP synthase; Region: ATP-synt; cl00365 471857007256 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 471857007257 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 471857007258 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 471857007259 beta subunit interaction interface [polypeptide binding]; other site 471857007260 Walker A motif; other site 471857007261 ATP binding site [chemical binding]; other site 471857007262 Walker B motif; other site 471857007263 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 471857007264 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 471857007265 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 471857007266 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 471857007267 ATP synthase A chain; Region: ATP-synt_A; cl00413 471857007268 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 471857007269 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 471857007270 Mg++ binding site [ion binding]; other site 471857007271 putative catalytic motif [active] 471857007272 substrate binding site [chemical binding]; other site 471857007273 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 471857007274 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 471857007275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471857007276 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 471857007277 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471857007278 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471857007279 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471857007280 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857007281 Walker A/P-loop; other site 471857007282 ATP binding site [chemical binding]; other site 471857007283 Q-loop/lid; other site 471857007284 ABC transporter signature motif; other site 471857007285 Walker B; other site 471857007286 D-loop; other site 471857007287 H-loop/switch region; other site 471857007288 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 471857007289 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471857007290 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 471857007291 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 471857007292 Acyl transferase domain; Region: Acyl_transf_1; cl08282 471857007293 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 471857007294 short chain dehydrogenase; Validated; Region: PRK05855 471857007295 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 471857007296 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 471857007297 FMN binding site [chemical binding]; other site 471857007298 dimer interface [polypeptide binding]; other site 471857007299 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 471857007300 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 471857007301 dimer interface [polypeptide binding]; other site 471857007302 active site 471857007303 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 471857007304 active site 471857007305 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 471857007306 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 471857007307 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 471857007308 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471857007309 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857007310 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 471857007311 NAD(P) binding site [chemical binding]; other site 471857007312 active site 471857007313 hypothetical protein; Provisional; Region: PRK06126 471857007314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857007315 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857007316 Bacterial transcriptional activator domain; Region: BTAD; smart01043 471857007317 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 471857007318 glycosyltransferase, MGT family; Region: MGT; TIGR01426 471857007319 active site 471857007320 TDP-binding site; other site 471857007321 acceptor substrate-binding pocket; other site 471857007322 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 471857007323 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 471857007324 inhibitor-cofactor binding pocket; inhibition site 471857007325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857007326 catalytic residue [active] 471857007327 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 471857007328 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 471857007329 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857007330 Hypothetical methyltransferase; Region: Methyltransf_13; pfam08421 471857007331 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 471857007332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471857007333 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 471857007334 Predicted ATPase [General function prediction only]; Region: COG3899 471857007335 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471857007336 DNA binding residues [nucleotide binding] 471857007337 dimerization interface [polypeptide binding]; other site 471857007338 peptide chain release factor 1; Validated; Region: prfA; PRK00591 471857007339 RF-1 domain; Region: RF-1; cl02875 471857007340 RF-1 domain; Region: RF-1; cl02875 471857007341 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 471857007342 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 471857007343 transcription termination factor Rho; Provisional; Region: PRK12608 471857007344 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459 471857007345 RNA binding site [nucleotide binding]; other site 471857007346 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 471857007347 multimer interface [polypeptide binding]; other site 471857007348 Walker A motif; other site 471857007349 ATP binding site [chemical binding]; other site 471857007350 Walker B motif; other site 471857007351 homoserine kinase; Provisional; Region: PRK01212 471857007352 threonine synthase; Reviewed; Region: PRK06721 471857007353 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563 471857007354 homodimer interface [polypeptide binding]; other site 471857007355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857007356 catalytic residue [active] 471857007357 homoserine dehydrogenase; Provisional; Region: PRK06349 471857007358 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857007359 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 471857007360 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 471857007361 diaminopimelate decarboxylase; Region: lysA; TIGR01048 471857007362 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 471857007363 active site 471857007364 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471857007365 substrate binding site [chemical binding]; other site 471857007366 catalytic residues [active] 471857007367 dimer interface [polypeptide binding]; other site 471857007368 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 471857007369 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 471857007370 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 471857007371 active site 471857007372 HIGH motif; other site 471857007373 KMSK motif region; other site 471857007374 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 471857007375 tRNA binding surface [nucleotide binding]; other site 471857007376 anticodon binding site; other site 471857007377 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 471857007378 Domain of unknown function (DUF305); Region: DUF305; pfam03713 471857007379 Domain of unknown function (DUF305); Region: DUF305; pfam03713 471857007380 Cation efflux family; Region: Cation_efflux; cl00316 471857007381 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 471857007382 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 471857007383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857007384 putative substrate translocation pore; other site 471857007385 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857007386 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471857007387 Peptidase M15; Region: Peptidase_M15_3; cl01194 471857007388 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 471857007389 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471857007390 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl11605 471857007391 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 471857007392 N-acetyl-D-glucosamine binding site [chemical binding]; other site 471857007393 catalytic residue [active] 471857007394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857007395 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 471857007396 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 471857007397 PYR/PP interface [polypeptide binding]; other site 471857007398 dimer interface [polypeptide binding]; other site 471857007399 TPP binding site [chemical binding]; other site 471857007400 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 471857007401 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cd00568 471857007402 TPP-binding site [chemical binding]; other site 471857007403 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 471857007404 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471857007405 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 471857007406 putative dimer interface [polypeptide binding]; other site 471857007407 N-terminal domain interface [polypeptide binding]; other site 471857007408 putative substrate binding pocket (H-site) [chemical binding]; other site 471857007409 putative amidase; Provisional; Region: PRK06169 471857007410 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 471857007411 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 471857007412 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857007413 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 471857007414 Transcriptional regulators [Transcription]; Region: GntR; COG1802 471857007415 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857007416 DNA-binding site [nucleotide binding]; DNA binding site 471857007417 FCD domain; Region: FCD; cl11656 471857007418 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 471857007419 isocitrate dehydrogenase; Validated; Region: PRK06451 471857007420 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471857007421 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 471857007422 tetramerization interface [polypeptide binding]; other site 471857007423 NAD(P) binding site [chemical binding]; other site 471857007424 catalytic residues [active] 471857007425 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 471857007426 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 471857007427 inhibitor-cofactor binding pocket; inhibition site 471857007428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857007429 catalytic residue [active] 471857007430 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 471857007431 FAD binding domain; Region: FAD_binding_4; pfam01565 471857007432 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 471857007433 hypothetical protein; Validated; Region: PRK07586 471857007434 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 471857007435 PYR/PP interface [polypeptide binding]; other site 471857007436 dimer interface [polypeptide binding]; other site 471857007437 TPP binding site [chemical binding]; other site 471857007438 TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of benzoylformate to benzaldehyde and carbon dioxide. This...; Region: TPP_BFDC; cd02002 471857007439 TPP-binding site [chemical binding]; other site 471857007440 dimer interface [polypeptide binding]; other site 471857007441 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 471857007442 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471857007443 substrate binding site [chemical binding]; other site 471857007444 oxyanion hole (OAH) forming residues; other site 471857007445 trimer interface [polypeptide binding]; other site 471857007446 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 471857007447 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471857007448 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 471857007449 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471857007450 dimer interface [polypeptide binding]; other site 471857007451 active site 471857007452 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857007453 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857007454 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857007455 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857007456 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857007457 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857007458 active site 471857007459 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857007460 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857007461 active site 471857007462 Prolyl oligopeptidase, N-terminal beta-propeller domain; Region: Peptidase_S9_N; pfam02897 471857007463 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 471857007464 active site 471857007465 dimerization interface [polypeptide binding]; other site 471857007466 Flavoprotein; Region: Flavoprotein; cl08021 471857007467 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857007468 non-specific DNA binding site [nucleotide binding]; other site 471857007469 salt bridge; other site 471857007470 sequence-specific DNA binding site [nucleotide binding]; other site 471857007471 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 471857007472 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 471857007473 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 471857007474 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 471857007475 Multicomponent K+:H+antiporter; Region: 2a6301s04; TIGR00944 471857007476 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 471857007477 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 471857007478 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 471857007479 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 471857007480 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 471857007481 Protein of unknown function, DUF488; Region: DUF488; cl01246 471857007482 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 471857007483 putative dimer interface [polypeptide binding]; other site 471857007484 ligand binding site [chemical binding]; other site 471857007485 Zn binding site [ion binding]; other site 471857007486 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471857007487 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 471857007488 putative NAD(P) binding site [chemical binding]; other site 471857007489 Sodium:solute symporter family; Region: SSF; cl00456 471857007490 CE1758 family; Region: LLM_CE1758_fam; TIGR04036 471857007491 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471857007492 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471857007493 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 471857007494 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471857007495 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857007496 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857007497 active site 471857007498 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 471857007499 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471857007500 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 471857007501 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 471857007502 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 471857007503 carboxyltransferase (CT) interaction site; other site 471857007504 biotinylation site [posttranslational modification]; other site 471857007505 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 471857007506 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 471857007507 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 471857007508 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 471857007509 active site 471857007510 oxyanion hole [active] 471857007511 catalytic triad [active] 471857007512 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857007513 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857007514 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471857007515 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 471857007516 Walker A/P-loop; other site 471857007517 ATP binding site [chemical binding]; other site 471857007518 Q-loop/lid; other site 471857007519 ABC transporter signature motif; other site 471857007520 Walker B; other site 471857007521 D-loop; other site 471857007522 H-loop/switch region; other site 471857007523 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 471857007524 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471857007525 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 471857007526 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857007527 Walker A/P-loop; other site 471857007528 ATP binding site [chemical binding]; other site 471857007529 Q-loop/lid; other site 471857007530 ABC transporter signature motif; other site 471857007531 Walker B; other site 471857007532 D-loop; other site 471857007533 H-loop/switch region; other site 471857007534 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 471857007535 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 471857007536 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857007537 Walker A/P-loop; other site 471857007538 ATP binding site [chemical binding]; other site 471857007539 Q-loop/lid; other site 471857007540 ABC transporter signature motif; other site 471857007541 Walker B; other site 471857007542 D-loop; other site 471857007543 H-loop/switch region; other site 471857007544 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 471857007545 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 471857007546 TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of...; Region: TPP_E1_OGDC_like; cd02016 471857007547 TPP-binding site [chemical binding]; other site 471857007548 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 471857007549 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 471857007550 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 471857007551 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 471857007552 calcium binding site 2 [ion binding]; other site 471857007553 active site 471857007554 catalytic triad [active] 471857007555 calcium binding site 1 [ion binding]; other site 471857007556 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 471857007557 Protein of unknown function DUF43; Region: DUF43; pfam01861 471857007558 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 471857007559 Malic enzyme, N-terminal domain; Region: malic; pfam00390 471857007560 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 471857007561 putative NAD(P) binding site [chemical binding]; other site 471857007562 Cupin domain; Region: Cupin_2; cl09118 471857007563 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 471857007564 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 471857007565 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 471857007566 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471857007567 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 471857007568 catalytic core [active] 471857007569 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471857007570 Coenzyme A binding pocket [chemical binding]; other site 471857007571 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 471857007572 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 471857007573 Transcription factor WhiB; Region: Whib; pfam02467 471857007574 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 471857007575 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 471857007576 Histidine kinase; Region: HisKA_2; cl06527 471857007577 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857007578 ATP binding site [chemical binding]; other site 471857007579 Mg2+ binding site [ion binding]; other site 471857007580 G-X-G motif; other site 471857007581 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS); Region: YbaK_deacylase; cd00002 471857007582 putative deacylase active site [active] 471857007583 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471857007584 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857007585 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471857007586 DNA binding residues [nucleotide binding] 471857007587 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl11829 471857007588 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 471857007589 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 471857007590 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 471857007591 GTPase/OB domain interface [polypeptide binding]; other site 471857007592 GTPase/Zn-binding domain interface [polypeptide binding]; other site 471857007593 GTP/Mg2+ binding site [chemical binding]; other site 471857007594 G4 box; other site 471857007595 G5 box; other site 471857007596 G1 box; other site 471857007597 Switch I region; other site 471857007598 G2 box; other site 471857007599 G3 box; other site 471857007600 Switch II region; other site 471857007601 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 471857007602 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471857007603 Glutamate binding site [chemical binding]; other site 471857007604 NAD binding site [chemical binding]; other site 471857007605 catalytic residues [active] 471857007606 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 471857007607 Condensation domain; Region: Condensation; cl09290 471857007608 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 471857007609 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 471857007610 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 471857007611 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 471857007612 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 471857007613 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 471857007614 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 471857007615 30S subunit binding site; other site 471857007616 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 471857007617 lipoprotein LpqB; Provisional; Region: PRK13616 471857007618 Sporulation and spore germination; Region: Germane; cl11253 471857007619 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 471857007620 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 471857007621 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 471857007622 dimer interface [polypeptide binding]; other site 471857007623 phosphorylation site [posttranslational modification] 471857007624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857007625 ATP binding site [chemical binding]; other site 471857007626 Mg2+ binding site [ion binding]; other site 471857007627 G-X-G motif; other site 471857007628 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471857007629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471857007630 active site 471857007631 phosphorylation site [posttranslational modification] 471857007632 intermolecular recognition site; other site 471857007633 dimerization interface [polypeptide binding]; other site 471857007634 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 471857007635 DNA binding site [nucleotide binding] 471857007636 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471857007637 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857007638 Bacterial transcriptional regulator; Region: IclR; pfam01614 471857007639 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 471857007640 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 471857007641 TMP-binding site; other site 471857007642 ATP-binding site [chemical binding]; other site 471857007643 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 471857007644 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 471857007645 M28, and M42; Region: Zinc_peptidase_like; cl14876 471857007646 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 471857007647 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 471857007648 Trm112p-like protein; Region: Trm112p; cl01066 471857007649 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 471857007650 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 471857007651 active site 471857007652 substrate binding site [chemical binding]; other site 471857007653 metal binding site [ion binding]; metal-binding site 471857007654 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 471857007655 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 471857007656 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471857007657 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 471857007658 Transcription factor WhiB; Region: Whib; pfam02467 471857007659 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 471857007660 active site 471857007661 putative substrate binding region [chemical binding]; other site 471857007662 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 471857007663 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 471857007664 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471857007665 Walker A/P-loop; other site 471857007666 ATP binding site [chemical binding]; other site 471857007667 Q-loop/lid; other site 471857007668 ABC transporter signature motif; other site 471857007669 Walker B; other site 471857007670 D-loop; other site 471857007671 H-loop/switch region; other site 471857007672 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471857007673 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471857007674 Walker A/P-loop; other site 471857007675 ATP binding site [chemical binding]; other site 471857007676 Q-loop/lid; other site 471857007677 ABC transporter signature motif; other site 471857007678 Walker B; other site 471857007679 D-loop; other site 471857007680 H-loop/switch region; other site 471857007681 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471857007682 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471857007683 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 471857007684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857007685 dimer interface [polypeptide binding]; other site 471857007686 conserved gate region; other site 471857007687 putative PBP binding loops; other site 471857007688 ABC-ATPase subunit interface; other site 471857007689 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471857007690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857007691 dimer interface [polypeptide binding]; other site 471857007692 conserved gate region; other site 471857007693 putative PBP binding loops; other site 471857007694 ABC-ATPase subunit interface; other site 471857007695 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 471857007696 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471857007697 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 471857007698 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 471857007699 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 471857007700 G1 box; other site 471857007701 putative GEF interaction site [polypeptide binding]; other site 471857007702 GTP/Mg2+ binding site [chemical binding]; other site 471857007703 Switch I region; other site 471857007704 G2 box; other site 471857007705 G3 box; other site 471857007706 Switch II region; other site 471857007707 G4 box; other site 471857007708 G5 box; other site 471857007709 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 471857007710 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 471857007711 YCII-related domain; Region: YCII; cl00999 471857007712 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 471857007713 active site 471857007714 8-oxo-dGMP binding site [chemical binding]; other site 471857007715 nudix motif; other site 471857007716 metal binding site [ion binding]; metal-binding site 471857007717 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 471857007718 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857007719 Walker A/P-loop; other site 471857007720 ATP binding site [chemical binding]; other site 471857007721 Q-loop/lid; other site 471857007722 ABC transporter signature motif; other site 471857007723 Walker B; other site 471857007724 D-loop; other site 471857007725 H-loop/switch region; other site 471857007726 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 471857007727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 471857007728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 471857007729 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 471857007730 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471857007731 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 471857007732 aromatic arch; other site 471857007733 DCoH dimer interaction site [polypeptide binding]; other site 471857007734 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 471857007735 DCoH tetramer interaction site [polypeptide binding]; other site 471857007736 substrate binding site [chemical binding]; other site 471857007737 Phosphotransferase enzyme family; Region: APH; pfam01636 471857007738 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471857007739 substrate binding site [chemical binding]; other site 471857007740 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471857007741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471857007742 active site 471857007743 phosphorylation site [posttranslational modification] 471857007744 intermolecular recognition site; other site 471857007745 dimerization interface [polypeptide binding]; other site 471857007746 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 471857007747 DNA binding site [nucleotide binding] 471857007748 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 471857007749 dimerization interface [polypeptide binding]; other site 471857007750 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 471857007751 dimer interface [polypeptide binding]; other site 471857007752 phosphorylation site [posttranslational modification] 471857007753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857007754 ATP binding site [chemical binding]; other site 471857007755 Mg2+ binding site [ion binding]; other site 471857007756 G-X-G motif; other site 471857007757 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 471857007758 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471857007759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471857007760 S-adenosylmethionine binding site [chemical binding]; other site 471857007761 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 471857007762 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471857007763 Coenzyme A binding pocket [chemical binding]; other site 471857007764 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 471857007765 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 471857007766 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857007767 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857007768 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 471857007769 GTP-binding protein YchF; Reviewed; Region: PRK09601 471857007770 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 471857007771 G1 box; other site 471857007772 GTP/Mg2+ binding site [chemical binding]; other site 471857007773 Switch I region; other site 471857007774 G2 box; other site 471857007775 Switch II region; other site 471857007776 G3 box; other site 471857007777 G4 box; other site 471857007778 G5 box; other site 471857007779 GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information on the function of the TGS domain, but...; Region: TGS; cl03735 471857007780 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 471857007781 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 471857007782 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471857007783 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 471857007784 AlkA N-terminal domain; Region: AlkA_N; cl05528 471857007785 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471857007786 minor groove reading motif; other site 471857007787 helix-hairpin-helix signature motif; other site 471857007788 substrate binding pocket [chemical binding]; other site 471857007789 active site 471857007790 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 471857007791 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 471857007792 DNA binding site [nucleotide binding] 471857007793 active site 471857007794 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857007795 Walker A/P-loop; other site 471857007796 ATP binding site [chemical binding]; other site 471857007797 Q-loop/lid; other site 471857007798 ABC transporter signature motif; other site 471857007799 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 471857007800 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857007801 Walker B; other site 471857007802 D-loop; other site 471857007803 H-loop/switch region; other site 471857007804 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 471857007805 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 471857007806 active site 471857007807 metal binding site [ion binding]; metal-binding site 471857007808 DNA binding site [nucleotide binding] 471857007809 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 471857007810 RmuC family; Region: RmuC; pfam02646 471857007811 LytB protein; Region: LYTB; cl00507 471857007812 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 471857007813 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 471857007814 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 471857007815 generic binding surface II; other site 471857007816 generic binding surface I; other site 471857007817 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 471857007818 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins [Carbohydrate transport and metabolism]; Region: GlpX; COG1494 471857007819 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 471857007820 putative active site [active] 471857007821 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857007822 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 471857007823 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857007824 fumarate hydratase; Reviewed; Region: fumC; PRK00485 471857007825 Class II fumarases; Region: Fumarase_classII; cd01362 471857007826 active site 471857007827 tetramer interface [polypeptide binding]; other site 471857007828 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857007829 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857007830 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 471857007831 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 471857007832 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cd02205 471857007833 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 471857007834 active site 471857007835 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 471857007836 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 471857007837 putative active site [active] 471857007838 PhoH-like protein; Region: PhoH; cl12134 471857007839 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 471857007840 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 471857007841 catalytic residue [active] 471857007842 putative FPP diphosphate binding site; other site 471857007843 putative FPP binding hydrophobic cleft; other site 471857007844 dimer interface [polypeptide binding]; other site 471857007845 putative IPP diphosphate binding site; other site 471857007846 Haemolysin-III related; Region: HlyIII; cl03831 471857007847 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471857007848 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 471857007849 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 471857007850 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 471857007851 BCCT family transporter; Region: BCCT; cl00569 471857007852 choline dehydrogenase; Validated; Region: PRK02106 471857007853 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857007854 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 471857007855 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 471857007856 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471857007857 tetramerization interface [polypeptide binding]; other site 471857007858 NAD(P) binding site [chemical binding]; other site 471857007859 catalytic residues [active] 471857007860 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 471857007861 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857007862 Tannase and feruloyl esterase; Region: Tannase; pfam07519 471857007863 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 471857007864 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 471857007865 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471857007866 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857007867 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857007868 active site 471857007869 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 471857007870 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein...; Region: SSP411; cd02955 471857007871 catalytic residues [active] 471857007872 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 471857007873 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 471857007874 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 471857007875 domain; Region: GreA_GreB_N; pfam03449 471857007876 C-term; Region: GreA_GreB; pfam01272 471857007877 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857007878 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 471857007879 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 471857007880 dimer interface [polypeptide binding]; other site 471857007881 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 471857007882 active site 471857007883 Fe binding site [ion binding]; other site 471857007884 threonine dehydratase; Provisional; Region: PRK08198 471857007885 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 471857007886 tetramer interface [polypeptide binding]; other site 471857007887 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857007888 catalytic residue [active] 471857007889 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 471857007890 cystathionine gamma-synthase; Provisional; Region: PRK07811 471857007891 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 471857007892 homodimer interface [polypeptide binding]; other site 471857007893 substrate-cofactor binding pocket; other site 471857007894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857007895 catalytic residue [active] 471857007896 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 471857007897 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 471857007898 dimer interface [polypeptide binding]; other site 471857007899 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857007900 catalytic residue [active] 471857007901 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as...; Region: CBS_pair_PALP_assoc2; cd04609 471857007902 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 471857007903 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471857007904 dimer interface [polypeptide binding]; other site 471857007905 active site 471857007906 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 471857007907 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan...; Region: Sortase_E; cd05829 471857007908 active site 471857007909 putative catalytic site [active] 471857007910 MAEBL; Provisional; Region: PTZ00121 471857007911 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 471857007912 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 471857007913 intersubunit interface [polypeptide binding]; other site 471857007914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471857007915 GAF domain; Region: GAF; cl00853 471857007916 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 471857007917 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 471857007918 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471857007919 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 471857007920 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471857007921 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 471857007922 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 471857007923 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471857007924 anti sigma factor interaction site; other site 471857007925 regulatory phosphorylation site [posttranslational modification]; other site 471857007926 polyol permease family; Region: 2A0118; TIGR00897 471857007927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857007928 putative substrate translocation pore; other site 471857007929 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 471857007930 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857007931 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 471857007932 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 471857007933 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 471857007934 motif II; other site 471857007935 dihydroxyacetone kinase; Provisional; Region: PRK14479 471857007936 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 471857007937 DAK2 domain; Region: Dak2; cl03685 471857007938 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 471857007939 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 471857007940 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857007941 L-xylulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 471857007942 putative N- and C-terminal domain interface [polypeptide binding]; other site 471857007943 D-xylulose kinase; Region: XylB; TIGR01312 471857007944 putative active site [active] 471857007945 putative MgATP binding site [chemical binding]; other site 471857007946 catalytic site [active] 471857007947 metal binding site [ion binding]; metal-binding site 471857007948 putative xylulose binding site [chemical binding]; other site 471857007949 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 471857007950 intersubunit interface [polypeptide binding]; other site 471857007951 active site 471857007952 Zn2+ binding site [ion binding]; other site 471857007953 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 471857007954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857007955 acetoin reductases; Region: 23BDH; TIGR02415 471857007956 NAD(P) binding site [chemical binding]; other site 471857007957 active site 471857007958 metabolite-proton symporter; Region: 2A0106; TIGR00883 471857007959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857007960 putative substrate translocation pore; other site 471857007961 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 471857007962 binding surface 471857007963 TPR motif; other site 471857007964 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 471857007965 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857007966 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 471857007967 Fe-S cluster binding site [ion binding]; other site 471857007968 DNA binding site [nucleotide binding] 471857007969 active site 471857007970 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 471857007971 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 471857007972 exopolyphosphatase; Region: exo_poly_only; TIGR03706 471857007973 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 471857007974 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 471857007975 N-acetyl-D-glucosamine binding site [chemical binding]; other site 471857007976 Protein of unknown function (DUF501); Region: DUF501; cl00652 471857007977 Septum formation initiator; Region: DivIC; cl11433 471857007978 enolase; Provisional; Region: eno; PRK00077 471857007979 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 471857007980 dimer interface [polypeptide binding]; other site 471857007981 metal binding site [ion binding]; metal-binding site 471857007982 substrate binding pocket [chemical binding]; other site 471857007983 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 471857007984 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 471857007985 TPR motif; other site 471857007986 binding surface 471857007987 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 471857007988 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 471857007989 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 471857007990 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 471857007991 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471857007992 ATP binding site [chemical binding]; other site 471857007993 putative Mg++ binding site [ion binding]; other site 471857007994 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857007995 nucleotide binding region [chemical binding]; other site 471857007996 ATP-binding site [chemical binding]; other site 471857007997 TRCF domain; Region: TRCF; cl04088 471857007998 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 471857007999 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 471857008000 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857008001 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857008002 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 471857008003 Di-iron ligands [ion binding]; other site 471857008004 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 471857008005 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 471857008006 metal binding site [ion binding]; metal-binding site 471857008007 active site 471857008008 I-site; other site 471857008009 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 471857008010 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 471857008011 Substrate binding site [chemical binding]; other site 471857008012 Mg++ binding site [ion binding]; other site 471857008013 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 471857008014 active site 471857008015 substrate binding site [chemical binding]; other site 471857008016 CoA binding site [chemical binding]; other site 471857008017 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 471857008018 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 471857008019 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 471857008020 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 471857008021 5S rRNA interface [nucleotide binding]; other site 471857008022 CTC domain interface [polypeptide binding]; other site 471857008023 L16 interface [polypeptide binding]; other site 471857008024 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 471857008025 putative active site [active] 471857008026 catalytic residue [active] 471857008027 DivIVA domain; Region: DivI1A_domain; TIGR03544 471857008028 DivIVA domain; Region: DivI1A_domain; TIGR03544 471857008029 DivIVA domain; Region: DivI1A_domain; TIGR03544 471857008030 DivIVA domain; Region: DivI1A_domain; TIGR03544 471857008031 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 471857008032 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857008033 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857008034 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471857008035 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 471857008036 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 471857008037 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 471857008038 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 471857008039 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857008040 Walker A/P-loop; other site 471857008041 ATP binding site [chemical binding]; other site 471857008042 Q-loop/lid; other site 471857008043 ABC transporter signature motif; other site 471857008044 Walker B; other site 471857008045 D-loop; other site 471857008046 H-loop/switch region; other site 471857008047 NIL domain; Region: NIL; cl09633 471857008048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471857008049 Domain of unknown function (DUF348); Region: DUF348; pfam03990 471857008050 Domain of unknown function (DUF348); Region: DUF348; pfam03990 471857008051 G5 domain; Region: G5; pfam07501 471857008052 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 471857008053 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 471857008054 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 471857008055 active site 471857008056 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 471857008057 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 471857008058 active site 471857008059 HIGH motif; other site 471857008060 KMSKS motif; other site 471857008061 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 471857008062 tRNA binding surface [nucleotide binding]; other site 471857008063 anticodon binding site; other site 471857008064 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 471857008065 chorismate binding enzyme; Region: Chorismate_bind; cl10555 471857008066 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 471857008067 Predicted methyltransferases [General function prediction only]; Region: COG0313 471857008068 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 471857008069 Predicted membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG4346 471857008070 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 471857008071 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471857008072 active site 471857008073 ATP binding site [chemical binding]; other site 471857008074 substrate binding site [chemical binding]; other site 471857008075 activation loop (A-loop); other site 471857008076 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 471857008077 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 471857008078 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857008079 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within...; Region: GH20_SpHex_like; cd06568 471857008080 active site 471857008081 tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233 471857008082 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 471857008083 active site 471857008084 HIGH motif; other site 471857008085 dimer interface [polypeptide binding]; other site 471857008086 KMSKS motif; other site 471857008087 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471857008088 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471857008089 active site 471857008090 ATP binding site [chemical binding]; other site 471857008091 substrate binding site [chemical binding]; other site 471857008092 activation loop (A-loop); other site 471857008093 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471857008094 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471857008095 active site 471857008096 ATP binding site [chemical binding]; other site 471857008097 substrate binding site [chemical binding]; other site 471857008098 activation loop (A-loop); other site 471857008099 glutamate dehydrogenase; Provisional; Region: PRK09414 471857008100 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 471857008101 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 471857008102 NAD(P) binding site [chemical binding]; other site 471857008103 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 471857008104 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471857008105 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 471857008106 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 471857008107 dimer interface [polypeptide binding]; other site 471857008108 putative functional site; other site 471857008109 putative MPT binding site; other site 471857008110 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471857008111 active site 471857008112 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 471857008113 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 471857008114 SAF domain; Region: SAF; cl00555 471857008115 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 471857008116 MPT binding site; other site 471857008117 trimer interface [polypeptide binding]; other site 471857008118 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 471857008119 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 471857008120 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 471857008121 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 471857008122 dimer interface [polypeptide binding]; other site 471857008123 active site 471857008124 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 471857008125 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857008126 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 471857008127 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 471857008128 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 471857008129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857008130 ATP binding site [chemical binding]; other site 471857008131 Mg2+ binding site [ion binding]; other site 471857008132 G-X-G motif; other site 471857008133 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471857008134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471857008135 active site 471857008136 phosphorylation site [posttranslational modification] 471857008137 intermolecular recognition site; other site 471857008138 dimerization interface [polypeptide binding]; other site 471857008139 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 471857008140 DNA binding site [nucleotide binding] 471857008141 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857008142 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471857008143 active site 471857008144 phosphorylation site [posttranslational modification] 471857008145 intermolecular recognition site; other site 471857008146 dimerization interface [polypeptide binding]; other site 471857008147 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471857008148 DNA binding residues [nucleotide binding] 471857008149 dimerization interface [polypeptide binding]; other site 471857008150 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 471857008151 potential frameshift: common BLAST hit: gi|256374724|ref|YP_003098384.1| YD repeat protein 471857008152 Proteins of 100 residues with WXG; Region: WXG100; cl02005 471857008153 RHS Repeat; Region: RHS_repeat; cl11982 471857008154 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 471857008155 RHS Repeat; Region: RHS_repeat; cl11982 471857008156 RHS Repeat; Region: RHS_repeat; cl11982 471857008157 RHS Repeat; Region: RHS_repeat; cl11982 471857008158 RHS Repeat; Region: RHS_repeat; cl11982 471857008159 RHS Repeat; Region: RHS_repeat; cl11982 471857008160 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 471857008161 enoyl-CoA hydratase; Provisional; Region: PRK08259 471857008162 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471857008163 substrate binding site [chemical binding]; other site 471857008164 oxyanion hole (OAH) forming residues; other site 471857008165 trimer interface [polypeptide binding]; other site 471857008166 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471857008167 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 471857008168 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 471857008169 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857008170 PE-PPE domain; Region: PE-PPE; pfam08237 471857008171 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857008172 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857008173 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 471857008174 glycosyltransferase, MGT family; Region: MGT; TIGR01426 471857008175 active site 471857008176 TDP-binding site; other site 471857008177 acceptor substrate-binding pocket; other site 471857008178 uncharacterized xylulose kinase-like proteins, subgroup 1; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 471857008179 N- and C-terminal domain interface [polypeptide binding]; other site 471857008180 D-xylulose kinase; Region: XylB; TIGR01312 471857008181 putative active site [active] 471857008182 catalytic site [active] 471857008183 metal binding site [ion binding]; metal-binding site 471857008184 putative xylulose binding site [chemical binding]; other site 471857008185 putative ATP binding site [chemical binding]; other site 471857008186 putative homodimer interface [polypeptide binding]; other site 471857008187 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 471857008188 PAS fold; Region: PAS_4; pfam08448 471857008189 GAF domain; Region: GAF; cl00853 471857008190 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471857008191 Histidine kinase; Region: HisKA_3; pfam07730 471857008192 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857008193 ATP binding site [chemical binding]; other site 471857008194 Mg2+ binding site [ion binding]; other site 471857008195 G-X-G motif; other site 471857008196 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857008197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471857008198 active site 471857008199 phosphorylation site [posttranslational modification] 471857008200 intermolecular recognition site; other site 471857008201 dimerization interface [polypeptide binding]; other site 471857008202 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471857008203 DNA binding residues [nucleotide binding] 471857008204 dimerization interface [polypeptide binding]; other site 471857008205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857008206 metabolite-proton symporter; Region: 2A0106; TIGR00883 471857008207 putative substrate translocation pore; other site 471857008208 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 471857008209 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 471857008210 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 471857008211 RHS Repeat; Region: RHS_repeat; cl11982 471857008212 RHS Repeat; Region: RHS_repeat; cl11982 471857008213 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 471857008214 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 471857008215 thioester formation/cholesterol transfer; other site 471857008216 protein-splicing catalytic site; other site 471857008217 Protein of unknown function (DUF1557); Region: DUF1557; pfam07591 471857008218 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 471857008219 Peptidase family M23; Region: Peptidase_M23; pfam01551 471857008220 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 471857008221 MgtE intracellular N domain; Region: MgtE_N; cl15244 471857008222 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 471857008223 Divalent cation transporter; Region: MgtE; cl00786 471857008224 Peptidase family M48; Region: Peptidase_M48; cl12018 471857008225 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 471857008226 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471857008227 ATP binding site [chemical binding]; other site 471857008228 putative Mg++ binding site [ion binding]; other site 471857008229 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857008230 nucleotide binding region [chemical binding]; other site 471857008231 ATP-binding site [chemical binding]; other site 471857008232 RQC domain; Region: RQC; cl09632 471857008233 HRDC domain; Region: HRDC; cl02578 471857008234 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 471857008235 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857008236 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 471857008237 FeoA domain; Region: FeoA; cl00838 471857008238 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471857008239 enoyl-CoA hydratase; Provisional; Region: PRK06688 471857008240 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471857008241 substrate binding site [chemical binding]; other site 471857008242 oxyanion hole (OAH) forming residues; other site 471857008243 trimer interface [polypeptide binding]; other site 471857008244 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 471857008245 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857008246 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857008247 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857008248 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471857008249 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857008250 active site 471857008251 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 471857008252 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 471857008253 isochorismate synthase DhbC; Validated; Region: PRK06923 471857008254 chorismate binding enzyme; Region: Chorismate_bind; cl10555 471857008255 flavoprotein, HI0933 family; Region: TIGR00275 471857008256 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857008257 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 471857008258 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 471857008259 putative active site [active] 471857008260 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471857008261 FAD binding domain; Region: FAD_binding_4; pfam01565 471857008262 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857008263 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 471857008264 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471857008265 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152 471857008266 heterotetramer interface [polypeptide binding]; other site 471857008267 active site pocket [active] 471857008268 cleavage site 471857008269 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471857008270 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 471857008271 dimerization interface [polypeptide binding]; other site 471857008272 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 471857008273 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 471857008274 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 471857008275 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 471857008276 peptide binding site [polypeptide binding]; other site 471857008277 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471857008278 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 471857008279 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 471857008280 PYR/PP interface [polypeptide binding]; other site 471857008281 dimer interface [polypeptide binding]; other site 471857008282 TPP binding site [chemical binding]; other site 471857008283 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 471857008284 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 471857008285 TPP-binding site [chemical binding]; other site 471857008286 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 471857008287 active site 471857008288 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 471857008289 Ligand Binding Site [chemical binding]; other site 471857008290 Molecular Tunnel; other site 471857008291 argininosuccinate lyase; Provisional; Region: PRK02186 471857008292 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 471857008293 Arginase family; Region: Arginase; cl00306 471857008294 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cd00250 471857008295 substrate binding pocket [chemical binding]; other site 471857008296 active site 471857008297 iron coordination sites [ion binding]; other site 471857008298 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 471857008299 peptide binding site [polypeptide binding]; other site 471857008300 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471857008301 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 471857008302 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471857008303 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 471857008304 EamA-like transporter family; Region: EamA; cl01037 471857008305 Beta-lactamase; Region: Beta-lactamase; cl01009 471857008306 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 471857008307 Cytochrome P450; Region: p450; cl12078 471857008308 short chain dehydrogenase; Provisional; Region: PRK12939 471857008309 clavulanic acid dehydrogenase (CAD), classical (c) SDR; Region: CAD_SDR_c; cd08934 471857008310 NADP binding site [chemical binding]; other site 471857008311 homotetramer interface [polypeptide binding]; other site 471857008312 homodimer interface [polypeptide binding]; other site 471857008313 active site 471857008314 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 471857008315 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471857008316 Coenzyme A binding pocket [chemical binding]; other site 471857008317 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857008318 DNA-binding site [nucleotide binding]; DNA binding site 471857008319 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471857008320 UTRA domain; Region: UTRA; cl01230 471857008321 Cytochrome P450; Region: p450; cl12078 471857008322 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 471857008323 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cd00882 471857008324 G1 box; other site 471857008325 GTP/Mg2+ binding site [chemical binding]; other site 471857008326 G2 box; other site 471857008327 Switch I region; other site 471857008328 G3 box; other site 471857008329 Switch II region; other site 471857008330 G4 box; other site 471857008331 G5 box; other site 471857008332 Protein of unknown function (DUF742); Region: DUF742; pfam05331 471857008333 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 471857008334 putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916 471857008335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471857008336 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 471857008337 Active_site [active] 471857008338 thiamine pyrophosphate protein; Provisional; Region: PRK08273 471857008339 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 471857008340 PYR/PP interface [polypeptide binding]; other site 471857008341 tetramer interface [polypeptide binding]; other site 471857008342 dimer interface [polypeptide binding]; other site 471857008343 TPP binding site [chemical binding]; other site 471857008344 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 471857008345 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX...; Region: TPP_POX; cd02014 471857008346 TPP-binding site [chemical binding]; other site 471857008347 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 471857008348 dimer interface [polypeptide binding]; other site 471857008349 Citrate synthase; Region: Citrate_synt; pfam00285 471857008350 active site 471857008351 citrylCoA binding site [chemical binding]; other site 471857008352 NADH binding [chemical binding]; other site 471857008353 cationic pore residues; other site 471857008354 oxalacetate/citrate binding site [chemical binding]; other site 471857008355 coenzyme A binding site [chemical binding]; other site 471857008356 catalytic triad [active] 471857008357 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 471857008358 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 471857008359 putative substrate binding site [chemical binding]; other site 471857008360 putative ATP binding site [chemical binding]; other site 471857008361 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857008362 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 471857008363 active site 471857008364 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 471857008365 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 471857008366 active site 471857008367 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 471857008368 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 471857008369 active site 471857008370 catalytic residues [active] 471857008371 SchA/CurD like domain; Region: SchA_CurD; pfam04486 471857008372 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 471857008373 Cupin domain; Region: Cupin_2; cl09118 471857008374 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 471857008375 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 471857008376 dimer interface [polypeptide binding]; other site 471857008377 active site 471857008378 Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic antibiotic-producing polyketide synthases (PKSs) of filamentous bacteria. CLFs have been shown to have decarboxylase activity towards malonyl-acyl carrier...; Region: CLF; cd00832 471857008379 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 471857008380 active site 471857008381 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471857008382 N-terminal aromatase/cyclase domain of the multifunctional protein tetracenomycin (TcmN) and related domains; Region: TcmN_ARO-CYC_like; cd08860 471857008383 putative hydrophobic ligand binding site [chemical binding]; other site 471857008384 active site 471857008385 catalytic residues_2 [active] 471857008386 catalytic residues_1 [active] 471857008387 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 471857008388 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 471857008389 acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Region: accD; TIGR00515 471857008390 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 471857008391 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 471857008392 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 471857008393 carboxyltransferase (CT) interaction site; other site 471857008394 biotinylation site [posttranslational modification]; other site 471857008395 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 471857008396 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471857008397 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 471857008398 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 471857008399 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857008400 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 471857008401 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 471857008402 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857008403 enterobactin exporter EntS; Provisional; Region: PRK10489 471857008404 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 471857008405 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471857008406 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 471857008407 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A (...; Region: CS_ACL-C_CCL; cl00416 471857008408 Citrate synthase; Region: Citrate_synt; pfam00285 471857008409 oxalacetate binding site [chemical binding]; other site 471857008410 citrylCoA binding site [chemical binding]; other site 471857008411 coenzyme A binding site [chemical binding]; other site 471857008412 catalytic triad [active] 471857008413 short chain dehydrogenase; Validated; Region: PRK05855 471857008414 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471857008415 classical (c) SDRs; Region: SDR_c; cd05233 471857008416 NAD(P) binding site [chemical binding]; other site 471857008417 active site 471857008418 L-lactate permease; Region: Lactate_perm; cl00701 471857008419 Beta-lactamase; Region: Beta-lactamase; cl01009 471857008420 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471857008421 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 471857008422 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471857008423 catalytic residue [active] 471857008424 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 471857008425 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 471857008426 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 471857008427 NAD binding site [chemical binding]; other site 471857008428 substrate binding site [chemical binding]; other site 471857008429 active site 471857008430 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 471857008431 Ligand binding site [chemical binding]; other site 471857008432 Putative Catalytic site [active] 471857008433 DXD motif; other site 471857008434 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857008435 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 471857008436 NAD(P) binding site [chemical binding]; other site 471857008437 active site 471857008438 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 471857008439 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 471857008440 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 471857008441 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 471857008442 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 471857008443 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 471857008444 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 471857008445 H+ Antiporter protein; Region: 2A0121; TIGR00900 471857008446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857008447 putative substrate translocation pore; other site 471857008448 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857008449 Sulfate transporter family; Region: Sulfate_transp; cl00967 471857008450 Permease family; Region: Xan_ur_permease; pfam00860 471857008451 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 471857008452 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 471857008453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857008454 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471857008455 putative substrate translocation pore; other site 471857008456 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 471857008457 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 471857008458 DNA-binding site [nucleotide binding]; DNA binding site 471857008459 RNA-binding motif; other site 471857008460 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 471857008461 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 471857008462 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 471857008463 active site 471857008464 diiron metal binding site [ion binding]; other site 471857008465 AMP-binding domain protein; Validated; Region: PRK08315 471857008466 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857008467 hypothetical protein; Provisional; Region: PRK11770 471857008468 Domain of unknown function (DUF307); Region: DUF307; pfam03733 471857008469 Domain of unknown function (DUF307); Region: DUF307; pfam03733 471857008470 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471857008471 active site 471857008472 metal binding site [ion binding]; metal-binding site 471857008473 UMP phosphatase; Provisional; Region: PRK10444 471857008474 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 471857008475 active site 471857008476 motif I; other site 471857008477 motif II; other site 471857008478 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 471857008479 active site 471857008480 motif I; other site 471857008481 motif II; other site 471857008482 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 471857008483 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857008484 Walker A/P-loop; other site 471857008485 ATP binding site [chemical binding]; other site 471857008486 Q-loop/lid; other site 471857008487 ABC transporter signature motif; other site 471857008488 Walker B; other site 471857008489 D-loop; other site 471857008490 H-loop/switch region; other site 471857008491 TOBE domain; Region: TOBE_2; cl01440 471857008492 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857008493 putative PBP binding loops; other site 471857008494 ABC-ATPase subunit interface; other site 471857008495 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471857008496 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 471857008497 DNA binding residues [nucleotide binding] 471857008498 TOBE domain; Region: TOBE_2; cl01440 471857008499 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 471857008500 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 471857008501 FeS/SAM binding site; other site 471857008502 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 471857008503 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 471857008504 MoaE interaction surface [polypeptide binding]; other site 471857008505 MoeB interaction surface [polypeptide binding]; other site 471857008506 thiocarboxylated glycine; other site 471857008507 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 471857008508 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 471857008509 putative peptidoglycan binding site; other site 471857008510 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 471857008511 MPT binding site; other site 471857008512 trimer interface [polypeptide binding]; other site 471857008513 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 471857008514 MoaD interaction [polypeptide binding]; other site 471857008515 active site residues [active] 471857008516 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420 471857008517 trimer interface [polypeptide binding]; other site 471857008518 dimer interface [polypeptide binding]; other site 471857008519 putative active site [active] 471857008520 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 471857008521 Malic enzyme, N-terminal domain; Region: malic; pfam00390 471857008522 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 471857008523 putative NAD(P) binding site [chemical binding]; other site 471857008524 Protein of unknown function (DUF742); Region: DUF742; pfam05331 471857008525 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 471857008526 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 471857008527 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cd00882 471857008528 G1 box; other site 471857008529 GTP/Mg2+ binding site [chemical binding]; other site 471857008530 G2 box; other site 471857008531 Switch I region; other site 471857008532 G3 box; other site 471857008533 Switch II region; other site 471857008534 G4 box; other site 471857008535 G5 box; other site 471857008536 Protein of unknown function (DUF742); Region: DUF742; pfam05331 471857008537 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 471857008538 Nitrate and nitrite sensing; Region: NIT; pfam08376 471857008539 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471857008540 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 471857008541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857008542 ATP binding site [chemical binding]; other site 471857008543 Mg2+ binding site [ion binding]; other site 471857008544 G-X-G motif; other site 471857008545 Putative periplasminc binding protein (DUF178); Region: DUF178; cl15271 471857008546 NMT1/THI5 like; Region: NMT1; pfam09084 471857008547 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 471857008548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 471857008549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857008550 dimer interface [polypeptide binding]; other site 471857008551 conserved gate region; other site 471857008552 putative PBP binding loops; other site 471857008553 ABC-ATPase subunit interface; other site 471857008554 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 471857008555 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 471857008556 Walker A/P-loop; other site 471857008557 ATP binding site [chemical binding]; other site 471857008558 Q-loop/lid; other site 471857008559 ABC transporter signature motif; other site 471857008560 Walker B; other site 471857008561 D-loop; other site 471857008562 H-loop/switch region; other site 471857008563 Nitrate and nitrite sensing; Region: NIT; pfam08376 471857008564 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471857008565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857008566 ATP binding site [chemical binding]; other site 471857008567 Mg2+ binding site [ion binding]; other site 471857008568 G-X-G motif; other site 471857008569 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 471857008570 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 471857008571 DNA repair helicase rad25; Region: rad25; TIGR00603 471857008572 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 471857008573 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471857008574 ATP binding site [chemical binding]; other site 471857008575 putative Mg++ binding site [ion binding]; other site 471857008576 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857008577 nucleotide binding region [chemical binding]; other site 471857008578 ATP-binding site [chemical binding]; other site 471857008579 Protein of unknown function DUF72; Region: DUF72; cl00777 471857008580 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 471857008581 proposed catalytic triad [active] 471857008582 conserved cys residue [active] 471857008583 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 471857008584 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 471857008585 ring oligomerisation interface [polypeptide binding]; other site 471857008586 ATP/Mg binding site [chemical binding]; other site 471857008587 stacking interactions; other site 471857008588 hinge regions; other site 471857008589 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 471857008590 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 471857008591 putative ligand binding residues [chemical binding]; other site 471857008592 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 471857008593 ABC-ATPase subunit interface; other site 471857008594 dimer interface [polypeptide binding]; other site 471857008595 putative PBP binding regions; other site 471857008596 ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism]; Region: CeuC; COG4605 471857008597 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 471857008598 ABC-ATPase subunit interface; other site 471857008599 dimer interface [polypeptide binding]; other site 471857008600 putative PBP binding regions; other site 471857008601 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 471857008602 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 471857008603 Walker A/P-loop; other site 471857008604 ATP binding site [chemical binding]; other site 471857008605 Q-loop/lid; other site 471857008606 ABC transporter signature motif; other site 471857008607 Walker B; other site 471857008608 D-loop; other site 471857008609 H-loop/switch region; other site 471857008610 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471857008611 active site 471857008612 ATP binding site [chemical binding]; other site 471857008613 substrate binding site [chemical binding]; other site 471857008614 activation loop (A-loop); other site 471857008615 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 471857008616 DNA-binding site [nucleotide binding]; DNA binding site 471857008617 RNA-binding motif; other site 471857008618 Protein of unknown function DUF124; Region: DUF124; cl00884 471857008619 Protein of unknown function DUF124; Region: DUF124; cl00884 471857008620 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 471857008621 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 471857008622 dimer interface [polypeptide binding]; other site 471857008623 putative functional site; other site 471857008624 putative MPT binding site; other site 471857008625 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 471857008626 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 471857008627 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 471857008628 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; cl08347 471857008629 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 471857008630 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857008631 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471857008632 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 471857008633 Walker A motif; other site 471857008634 ATP binding site [chemical binding]; other site 471857008635 Walker B motif; other site 471857008636 arginine finger; other site 471857008637 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 471857008638 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 471857008639 active site 471857008640 catalytic residues [active] 471857008641 metal binding site [ion binding]; metal-binding site 471857008642 ThiC family; Region: ThiC; cl08031 471857008643 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 471857008644 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 471857008645 dimer interface [polypeptide binding]; other site 471857008646 substrate binding site [chemical binding]; other site 471857008647 ATP binding site [chemical binding]; other site 471857008648 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 471857008649 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 471857008650 substrate binding site [chemical binding]; other site 471857008651 dimer interface [polypeptide binding]; other site 471857008652 ATP binding site [chemical binding]; other site 471857008653 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857008654 Nodulation protein A (NodA); Region: NodA; cl03608 471857008655 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857008656 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 471857008657 ThiS interaction site; other site 471857008658 putative active site [active] 471857008659 tetramer interface [polypeptide binding]; other site 471857008660 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 471857008661 thiS-thiF/thiG interaction site; other site 471857008662 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 471857008663 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 471857008664 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 471857008665 thiamine phosphate binding site [chemical binding]; other site 471857008666 active site 471857008667 pyrophosphate binding site [ion binding]; other site 471857008668 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471857008669 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857008670 DNA-binding site [nucleotide binding]; DNA binding site 471857008671 UTRA domain; Region: UTRA; cl01230 471857008672 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 471857008673 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 471857008674 dimer interface [polypeptide binding]; other site 471857008675 active site 471857008676 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 471857008677 dimer interface [polypeptide binding]; other site 471857008678 active site 471857008679 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471857008680 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 471857008681 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 471857008682 active site 471857008683 catalytic triad [active] 471857008684 oxyanion hole [active] 471857008685 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 471857008686 ligand binding site [chemical binding]; other site 471857008687 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 471857008688 Cupin domain; Region: Cupin_2; cl09118 471857008689 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 471857008690 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 471857008691 inhibitor-cofactor binding pocket; inhibition site 471857008692 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857008693 catalytic residue [active] 471857008694 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471857008695 DinB superfamily; Region: DinB_2; cl00986 471857008696 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471857008697 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471857008698 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 471857008699 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471857008700 Predicted esterase [General function prediction only]; Region: COG0400 471857008701 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 471857008702 Zn binding site [ion binding]; other site 471857008703 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 471857008704 Zn binding site [ion binding]; other site 471857008705 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471857008706 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857008707 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 471857008708 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 471857008709 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 471857008710 active site 471857008711 DNA binding site [nucleotide binding] 471857008712 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 471857008713 DNA binding site [nucleotide binding] 471857008714 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for non-...; Region: MtLigD_Pol_like; cd04863 471857008715 nucleotide binding site [chemical binding]; other site 471857008716 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 471857008717 GAF domain; Region: GAF; cl00853 471857008718 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 471857008719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471857008720 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471857008721 anti sigma factor interaction site; other site 471857008722 regulatory phosphorylation site [posttranslational modification]; other site 471857008723 hypothetical protein; Provisional; Region: PRK02947 471857008724 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 471857008725 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 471857008726 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 471857008727 active site 471857008728 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471857008729 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 471857008730 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471857008731 active site residue [active] 471857008732 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 471857008733 B12 binding site [chemical binding]; other site 471857008734 GAF domain; Region: GAF; cl00853 471857008735 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 471857008736 Uncharacterized conserved protein [Function unknown]; Region: COG2966 471857008737 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 471857008738 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 471857008739 Glycosyltransferase family 20; Region: Glyco_transf_20; pfam00982 471857008740 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is...; Region: GT1_TPS; cd03788 471857008741 active site 471857008742 homotetramer interface [polypeptide binding]; other site 471857008743 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 471857008744 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 471857008745 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 471857008746 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 471857008747 DNA repair protein RadA; Provisional; Region: PRK11823 471857008748 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857008749 Walker A motif; other site 471857008750 ATP binding site [chemical binding]; other site 471857008751 Walker B motif; other site 471857008752 Protein of unknown function (DUF461); Region: DUF461; cl01071 471857008753 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 471857008754 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471857008755 active site 471857008756 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554 471857008757 homotrimer interaction site [polypeptide binding]; other site 471857008758 zinc binding site [ion binding]; other site 471857008759 CDP-binding sites; other site 471857008760 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 471857008761 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 471857008762 motif II; other site 471857008763 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 471857008764 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471857008765 active site 471857008766 HIGH motif; other site 471857008767 nucleotide binding site [chemical binding]; other site 471857008768 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 471857008769 KMSKS motif; other site 471857008770 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 471857008771 tRNA binding surface [nucleotide binding]; other site 471857008772 anticodon binding site; other site 471857008773 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 471857008774 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 471857008775 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 471857008776 MBOAT family; Region: MBOAT; cl00738 471857008777 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 471857008778 UvrD/REP helicase; Region: UvrD-helicase; cl14126 471857008779 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 471857008780 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857008781 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857008782 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 471857008783 ATP-binding site [chemical binding]; other site 471857008784 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 471857008785 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 471857008786 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471857008787 ATP binding site [chemical binding]; other site 471857008788 putative Mg++ binding site [ion binding]; other site 471857008789 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857008790 nucleotide binding region [chemical binding]; other site 471857008791 ATP-binding site [chemical binding]; other site 471857008792 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471857008793 active site 471857008794 ATP binding site [chemical binding]; other site 471857008795 substrate binding site [chemical binding]; other site 471857008796 activation loop (A-loop); other site 471857008797 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 471857008798 binding surface 471857008799 TPR motif; other site 471857008800 classical (c) SDRs; Region: SDR_c; cd05233 471857008801 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 471857008802 NAD(P) binding site [chemical binding]; other site 471857008803 active site 471857008804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 471857008805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 471857008806 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 471857008807 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 471857008808 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 471857008809 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 471857008810 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 471857008811 intersubunit interface [polypeptide binding]; other site 471857008812 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471857008813 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471857008814 DNA binding site [nucleotide binding] 471857008815 domain linker motif; other site 471857008816 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 471857008817 putative dimerization interface [polypeptide binding]; other site 471857008818 putative ligand binding site [chemical binding]; other site 471857008819 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 471857008820 active site clefts [active] 471857008821 zinc binding site [ion binding]; other site 471857008822 dimer interface [polypeptide binding]; other site 471857008823 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 471857008824 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471857008825 minor groove reading motif; other site 471857008826 helix-hairpin-helix signature motif; other site 471857008827 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 471857008828 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 471857008829 amidase catalytic site [active] 471857008830 Zn binding residues [ion binding]; other site 471857008831 substrate binding site [chemical binding]; other site 471857008832 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471857008833 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857008834 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857008835 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471857008836 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471857008837 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 471857008838 Zn binding site [ion binding]; other site 471857008839 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 471857008840 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195 471857008841 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857008842 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 471857008843 Walker A/P-loop; other site 471857008844 ATP binding site [chemical binding]; other site 471857008845 Q-loop/lid; other site 471857008846 ABC transporter signature motif; other site 471857008847 Walker B; other site 471857008848 D-loop; other site 471857008849 H-loop/switch region; other site 471857008850 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471857008851 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857008852 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 471857008853 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857008854 Clp protease ATP binding subunit; Region: clpC; CHL00095 471857008855 Clp amino terminal domain; Region: Clp_N; pfam02861 471857008856 Clp amino terminal domain; Region: Clp_N; pfam02861 471857008857 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471857008858 Walker A motif; other site 471857008859 ATP binding site [chemical binding]; other site 471857008860 Walker B motif; other site 471857008861 arginine finger; other site 471857008862 UvrB/uvrC motif; Region: UVR; pfam02151 471857008863 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471857008864 Walker A motif; other site 471857008865 ATP binding site [chemical binding]; other site 471857008866 Walker B motif; other site 471857008867 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 471857008868 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 471857008869 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 471857008870 Lsr2; Region: Lsr2; pfam11774 471857008871 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 471857008872 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 471857008873 tetramerization interface [polypeptide binding]; other site 471857008874 active site 471857008875 pantoate--beta-alanine ligase; Region: panC; TIGR00018 471857008876 Pantoate-beta-alanine ligase; Region: PanC; cd00560 471857008877 active site 471857008878 ATP-binding site [chemical binding]; other site 471857008879 pantoate-binding site; other site 471857008880 HXXH motif; other site 471857008881 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857008882 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 471857008883 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 471857008884 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471857008885 DNA binding residues [nucleotide binding] 471857008886 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 471857008887 catalytic center binding site [active] 471857008888 ATP binding site [chemical binding]; other site 471857008889 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines...; Region: DHNA_DHNTPE; cd00534 471857008890 homooctamer interface [polypeptide binding]; other site 471857008891 active site 471857008892 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 471857008893 dihydropteroate synthase; Region: DHPS; TIGR01496 471857008894 substrate binding pocket [chemical binding]; other site 471857008895 dimer interface [polypeptide binding]; other site 471857008896 inhibitor binding site; inhibition site 471857008897 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 471857008898 homodecamer interface [polypeptide binding]; other site 471857008899 active site 471857008900 putative catalytic site residues [active] 471857008901 zinc binding site [ion binding]; other site 471857008902 GTP-CH-I/GFRP interaction surface; other site 471857008903 FtsH Extracellular; Region: FtsH_ext; pfam06480 471857008904 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 471857008905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471857008906 Walker A motif; other site 471857008907 ATP binding site [chemical binding]; other site 471857008908 Walker B motif; other site 471857008909 arginine finger; other site 471857008910 Peptidase family M41; Region: Peptidase_M41; pfam01434 471857008911 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 471857008912 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 471857008913 Ligand Binding Site [chemical binding]; other site 471857008914 Uncharacterised conserved protein (DUF2342); Region: DUF2342; cl02183 471857008915 PBP4 family; Region: PBP4; TIGR00666 471857008916 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297 471857008917 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 471857008918 dimer interface [polypeptide binding]; other site 471857008919 substrate binding site [chemical binding]; other site 471857008920 metal binding sites [ion binding]; metal-binding site 471857008921 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 471857008922 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 471857008923 trimer interface [polypeptide binding]; other site 471857008924 putative metal binding site [ion binding]; other site 471857008925 DNA polymerase III subunit delta'; Validated; Region: PRK07940 471857008926 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857008927 H+ Antiporter protein; Region: 2A0121; TIGR00900 471857008928 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 471857008929 TMP-binding site; other site 471857008930 ATP-binding site [chemical binding]; other site 471857008931 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 471857008932 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 471857008933 active site 471857008934 interdomain interaction site; other site 471857008935 putative metal-binding site [ion binding]; other site 471857008936 nucleotide binding site [chemical binding]; other site 471857008937 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cl11986 471857008938 domain I; other site 471857008939 phosphate binding site [ion binding]; other site 471857008940 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 471857008941 domain II; other site 471857008942 domain III; other site 471857008943 nucleotide binding site [chemical binding]; other site 471857008944 DNA binding groove [nucleotide binding] 471857008945 catalytic site [active] 471857008946 domain IV; other site 471857008947 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 471857008948 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 471857008949 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 471857008950 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471857008951 ATP binding site [chemical binding]; other site 471857008952 putative Mg++ binding site [ion binding]; other site 471857008953 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471857008954 nucleotide binding region [chemical binding]; other site 471857008955 ATP-binding site [chemical binding]; other site 471857008956 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 471857008957 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 471857008958 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 471857008959 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 471857008960 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 471857008961 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 471857008962 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 471857008963 Walker A motif; other site 471857008964 hexamer interface [polypeptide binding]; other site 471857008965 ATP binding site [chemical binding]; other site 471857008966 Walker B motif; other site 471857008967 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 471857008968 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 471857008969 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 471857008970 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 471857008971 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 471857008972 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 471857008973 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 471857008974 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471857008975 Beta-lactamase; Region: Beta-lactamase; cl01009 471857008976 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 471857008977 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 471857008978 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 471857008979 putative active site [active] 471857008980 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 471857008981 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 471857008982 putative active site [active] 471857008983 acetyl-CoA synthetase; Provisional; Region: PRK00174 471857008984 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 471857008985 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471857008986 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 471857008987 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 471857008988 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 471857008989 Chlorophyllase; Region: Chlorophyllase; cl15281 471857008990 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471857008991 serine endoprotease; Provisional; Region: PRK10942 471857008992 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 471857008993 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 471857008994 putative active site [active] 471857008995 putative CoA binding site [chemical binding]; other site 471857008996 nudix motif; other site 471857008997 metal binding site [ion binding]; metal-binding site 471857008998 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 471857008999 catalytic residues [active] 471857009000 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 471857009001 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471857009002 minor groove reading motif; other site 471857009003 helix-hairpin-helix signature motif; other site 471857009004 substrate binding pocket [chemical binding]; other site 471857009005 active site 471857009006 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 471857009007 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 471857009008 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471857009009 ligand binding site [chemical binding]; other site 471857009010 flexible hinge region; other site 471857009011 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857009012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857009013 putative substrate translocation pore; other site 471857009014 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471857009015 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 471857009016 homotrimer interaction site [polypeptide binding]; other site 471857009017 putative active site [active] 471857009018 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 471857009019 DTAP/Switch II; other site 471857009020 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 471857009021 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 471857009022 DTAP/Switch II; other site 471857009023 Switch I; other site 471857009024 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 471857009025 Transcription factor WhiB; Region: Whib; pfam02467 471857009026 Transglycosylase; Region: Transgly; cl07896 471857009027 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 471857009028 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 471857009029 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 471857009030 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471857009031 putative active site [active] 471857009032 putative metal binding site [ion binding]; other site 471857009033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471857009034 S-adenosylmethionine binding site [chemical binding]; other site 471857009035 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 471857009036 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471857009037 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471857009038 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 471857009039 Ferritin-like domain; Region: Ferritin; pfam00210 471857009040 dimerization interface [polypeptide binding]; other site 471857009041 DPS ferroxidase diiron center [ion binding]; other site 471857009042 ion pore; other site 471857009043 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 471857009044 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471857009045 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 471857009046 substrate binding pocket [chemical binding]; other site 471857009047 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471857009048 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 471857009049 metal binding site 2 [ion binding]; metal-binding site 471857009050 putative DNA binding helix; other site 471857009051 metal binding site 1 [ion binding]; metal-binding site 471857009052 dimer interface [polypeptide binding]; other site 471857009053 structural Zn2+ binding site [ion binding]; other site 471857009054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857009055 putative substrate translocation pore; other site 471857009056 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 471857009057 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857009058 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 471857009059 aspartate kinase; Reviewed; Region: PRK06635 471857009060 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 471857009061 putative nucleotide binding site [chemical binding]; other site 471857009062 putative catalytic residues [active] 471857009063 putative Mg ion binding site [ion binding]; other site 471857009064 putative aspartate binding site [chemical binding]; other site 471857009065 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 471857009066 putative allosteric regulatory site; other site 471857009067 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 471857009068 putative allosteric regulatory residue; other site 471857009069 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 471857009070 putative FMN binding site [chemical binding]; other site 471857009071 2-isopropylmalate synthase; Validated; Region: PRK03739 471857009072 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 471857009073 active site 471857009074 catalytic residues [active] 471857009075 metal binding site [ion binding]; metal-binding site 471857009076 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 471857009077 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 471857009078 Predicted transcriptional regulator [Transcription]; Region: COG2378 471857009079 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857009080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857009081 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 471857009082 NAD(P) binding site [chemical binding]; other site 471857009083 active site 471857009084 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857009085 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 471857009086 putative dimerization interface [polypeptide binding]; other site 471857009087 CoA-transferase family III; Region: CoA_transf_3; cl00778 471857009088 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 471857009089 EamA-like transporter family; Region: EamA; cl01037 471857009090 EamA-like transporter family; Region: EamA; cl01037 471857009091 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 471857009092 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471857009093 Walker A/P-loop; other site 471857009094 ATP binding site [chemical binding]; other site 471857009095 Q-loop/lid; other site 471857009096 ABC transporter signature motif; other site 471857009097 Walker B; other site 471857009098 D-loop; other site 471857009099 H-loop/switch region; other site 471857009100 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471857009101 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 471857009102 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471857009103 Walker A/P-loop; other site 471857009104 ATP binding site [chemical binding]; other site 471857009105 Q-loop/lid; other site 471857009106 ABC transporter signature motif; other site 471857009107 Walker B; other site 471857009108 D-loop; other site 471857009109 H-loop/switch region; other site 471857009110 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471857009111 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471857009112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857009113 dimer interface [polypeptide binding]; other site 471857009114 conserved gate region; other site 471857009115 ABC-ATPase subunit interface; other site 471857009116 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471857009117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857009118 dimer interface [polypeptide binding]; other site 471857009119 conserved gate region; other site 471857009120 putative PBP binding loops; other site 471857009121 ABC-ATPase subunit interface; other site 471857009122 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 471857009123 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471857009124 peptide binding site [polypeptide binding]; other site 471857009125 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471857009126 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857009127 Active site [active] 471857009128 G1 box; other site 471857009129 GTP/Mg2+ binding site [chemical binding]; other site 471857009130 recombination protein RecR; Reviewed; Region: recR; PRK00076 471857009131 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 471857009132 RecR protein; Region: RecR; pfam02132 471857009133 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 471857009134 putative active site [active] 471857009135 putative metal-binding site [ion binding]; other site 471857009136 tetramer interface [polypeptide binding]; other site 471857009137 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 471857009138 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 471857009139 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471857009140 Walker A motif; other site 471857009141 ATP binding site [chemical binding]; other site 471857009142 Walker B motif; other site 471857009143 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 471857009144 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471857009145 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471857009146 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471857009147 non-specific DNA binding site [nucleotide binding]; other site 471857009148 salt bridge; other site 471857009149 sequence-specific DNA binding site [nucleotide binding]; other site 471857009150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857009151 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 471857009152 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 471857009153 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 471857009154 Cation transport protein; Region: TrkH; cl10514 471857009155 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 471857009156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857009157 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 471857009158 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 471857009159 substrate binding site [chemical binding]; other site 471857009160 THF binding site; other site 471857009161 zinc-binding site [ion binding]; other site 471857009162 transketolase; Reviewed; Region: PRK05899 471857009163 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 471857009164 TPP-binding site [chemical binding]; other site 471857009165 dimer interface [polypeptide binding]; other site 471857009166 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 471857009167 PYR/PP interface [polypeptide binding]; other site 471857009168 dimer interface [polypeptide binding]; other site 471857009169 TPP binding site [chemical binding]; other site 471857009170 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471857009171 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 471857009172 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471857009173 metal-binding site [ion binding] 471857009174 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471857009175 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471857009176 metal-binding site [ion binding] 471857009177 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 471857009178 putative homotetramer interface [polypeptide binding]; other site 471857009179 putative homodimer interface [polypeptide binding]; other site 471857009180 putative allosteric switch controlling residues; other site 471857009181 putative metal binding site [ion binding]; other site 471857009182 putative homodimer-homodimer interface [polypeptide binding]; other site 471857009183 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 471857009184 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857009185 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 471857009186 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471857009187 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 471857009188 Switch II region; other site 471857009189 G3 box; other site 471857009190 G4 box; other site 471857009191 G5 box; other site 471857009192 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 471857009193 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 471857009194 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471857009195 DNA binding residues [nucleotide binding] 471857009196 dimerization interface [polypeptide binding]; other site 471857009197 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 471857009198 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 471857009199 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl14635 471857009200 LGFP repeat; Region: LGFP; pfam08310 471857009201 LGFP repeat; Region: LGFP; pfam08310 471857009202 LGFP repeat; Region: LGFP; pfam08310 471857009203 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 471857009204 nucleoside/Zn binding site; other site 471857009205 dimer interface [polypeptide binding]; other site 471857009206 catalytic motif [active] 471857009207 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 471857009208 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 471857009209 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 471857009210 metal binding site [ion binding]; metal-binding site 471857009211 dimer interface [polypeptide binding]; other site 471857009212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857009213 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 471857009214 hypothetical membrane protein, TIGR01666; Region: YCCS 471857009215 Predicted transcriptional regulators [Transcription]; Region: COG1510 471857009216 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857009217 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471857009218 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 471857009219 Walker A/P-loop; other site 471857009220 ATP binding site [chemical binding]; other site 471857009221 Q-loop/lid; other site 471857009222 ABC transporter signature motif; other site 471857009223 Walker B; other site 471857009224 D-loop; other site 471857009225 H-loop/switch region; other site 471857009226 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 471857009227 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471857009228 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 471857009229 tetramerization interface [polypeptide binding]; other site 471857009230 NAD(P) binding site [chemical binding]; other site 471857009231 catalytic residues [active] 471857009232 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976 471857009233 catalytic residues [active] 471857009234 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857009235 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857009236 OsmC-like protein; Region: OsmC; cl00767 471857009237 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 471857009238 active site 471857009239 putative diguanylate cyclase; Provisional; Region: PRK09776 471857009240 PAS domain S-box; Region: sensory_box; TIGR00229 471857009241 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471857009242 putative active site [active] 471857009243 heme pocket [chemical binding]; other site 471857009244 PAS domain S-box; Region: sensory_box; TIGR00229 471857009245 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 471857009246 PAS fold; Region: PAS_4; pfam08448 471857009247 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471857009248 putative active site [active] 471857009249 heme pocket [chemical binding]; other site 471857009250 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 471857009251 metal binding site [ion binding]; metal-binding site 471857009252 active site 471857009253 I-site; other site 471857009254 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 471857009255 Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674 471857009256 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 471857009257 Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674 471857009258 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 471857009259 Cysteine-rich domain; Region: CCG; pfam02754 471857009260 Cysteine-rich domain; Region: CCG; pfam02754 471857009261 YceI-like domain; Region: YceI; cl01001 471857009262 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 471857009263 DNA-binding site [nucleotide binding]; DNA binding site 471857009264 RNA-binding motif; other site 471857009265 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 471857009266 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 471857009267 CoenzymeA binding site [chemical binding]; other site 471857009268 subunit interaction site [polypeptide binding]; other site 471857009269 PHB binding site; other site 471857009270 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 471857009271 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471857009272 putative active site [active] 471857009273 putative metal binding site [ion binding]; other site 471857009274 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471857009275 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471857009276 active site 471857009277 ATP binding site [chemical binding]; other site 471857009278 substrate binding site [chemical binding]; other site 471857009279 activation loop (A-loop); other site 471857009280 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 471857009281 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 471857009282 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 471857009283 substrate binding pocket [chemical binding]; other site 471857009284 membrane-bound complex binding site; other site 471857009285 hinge residues; other site 471857009286 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 471857009287 active site 471857009288 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857009289 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 471857009290 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 471857009291 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857009292 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 471857009293 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 471857009294 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 471857009295 Ligand binding site [chemical binding]; other site 471857009296 Putative Catalytic site [active] 471857009297 DXD motif; other site 471857009298 argininosuccinate lyase; Provisional; Region: PRK02186 471857009299 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 471857009300 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 471857009301 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 471857009302 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 471857009303 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 471857009304 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and...; Region: IPP_Isomerase; cd02885 471857009305 active site 471857009306 metal binding site [ion binding]; metal-binding site 471857009307 nudix motif; other site 471857009308 Nitrate and nitrite sensing; Region: NIT; pfam08376 471857009309 putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916 471857009310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857009311 ATP binding site [chemical binding]; other site 471857009312 Mg2+ binding site [ion binding]; other site 471857009313 G-X-G motif; other site 471857009314 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 471857009315 Protein of unknown function (DUF742); Region: DUF742; pfam05331 471857009316 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 471857009317 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cd00882 471857009318 G2 box; other site 471857009319 Switch I region; other site 471857009320 G3 box; other site 471857009321 Switch II region; other site 471857009322 GTP/Mg2+ binding site [chemical binding]; other site 471857009323 G4 box; other site 471857009324 G5 box; other site 471857009325 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 471857009326 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471857009327 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471857009328 catalytic residue [active] 471857009329 aromatic prenyltransferase, DMATS type; Region: arom_pren_DMATS; TIGR03429 471857009330 EamA-like transporter family; Region: EamA; cl01037 471857009331 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cl00891 471857009332 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 471857009333 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 471857009334 FMN binding site [chemical binding]; other site 471857009335 active site 471857009336 catalytic residues [active] 471857009337 substrate binding site [chemical binding]; other site 471857009338 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 471857009339 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 471857009340 PhoU domain; Region: PhoU; pfam01895 471857009341 PhoU domain; Region: PhoU; pfam01895 471857009342 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471857009343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 471857009344 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 471857009345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857009346 dimer interface [polypeptide binding]; other site 471857009347 conserved gate region; other site 471857009348 putative PBP binding loops; other site 471857009349 ABC-ATPase subunit interface; other site 471857009350 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 471857009351 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 471857009352 Walker A/P-loop; other site 471857009353 ATP binding site [chemical binding]; other site 471857009354 Q-loop/lid; other site 471857009355 ABC transporter signature motif; other site 471857009356 Walker B; other site 471857009357 D-loop; other site 471857009358 H-loop/switch region; other site 471857009359 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 471857009360 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471857009361 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471857009362 DNA-binding response regulator CreB; Provisional; Region: PRK11083 471857009363 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 471857009364 DNA binding site [nucleotide binding] 471857009365 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471857009366 catalytic residues [active] 471857009367 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 471857009368 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 471857009369 active site residue [active] 471857009370 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 471857009371 active site residue [active] 471857009372 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 471857009373 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 471857009374 heme-binding site [chemical binding]; other site 471857009375 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 471857009376 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857009377 Aminotransferase class IV; Region: Aminotran_4; pfam01063 471857009378 catalytic residue [active] 471857009379 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 471857009380 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 471857009381 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 471857009382 L-asparaginase II; Region: Asparaginase_II; cl01842 471857009383 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 471857009384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857009385 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 471857009386 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 471857009387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 471857009388 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 471857009389 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 471857009390 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 471857009391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857009392 ATP binding site [chemical binding]; other site 471857009393 Mg2+ binding site [ion binding]; other site 471857009394 G-X-G motif; other site 471857009395 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 471857009396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471857009397 active site 471857009398 phosphorylation site [posttranslational modification] 471857009399 intermolecular recognition site; other site 471857009400 dimerization interface [polypeptide binding]; other site 471857009401 RF-1 domain; Region: RF-1; cl02875 471857009402 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 471857009403 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 471857009404 dimerization interface [polypeptide binding]; other site 471857009405 putative ATP binding site [chemical binding]; other site 471857009406 amidophosphoribosyltransferase; Provisional; Region: PRK07847 471857009407 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 471857009408 active site 471857009409 tetramer interface [polypeptide binding]; other site 471857009410 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 471857009411 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 471857009412 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471857009413 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471857009414 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme (; Region: GH25_CH-type; cd06412 471857009415 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 471857009416 active site 471857009417 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK11907 471857009418 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 471857009419 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 471857009420 dimerization interface [polypeptide binding]; other site 471857009421 ATP binding site [chemical binding]; other site 471857009422 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 471857009423 dimerization interface [polypeptide binding]; other site 471857009424 ATP binding site [chemical binding]; other site 471857009425 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 471857009426 putative active site [active] 471857009427 catalytic triad [active] 471857009428 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 471857009429 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471857009430 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 471857009431 NAD(P) binding site [chemical binding]; other site 471857009432 catalytic residues [active] 471857009433 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471857009434 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 471857009435 adenylosuccinate lyase; Region: purB; TIGR00928 471857009436 tetramer interface [polypeptide binding]; other site 471857009437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 471857009438 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 471857009439 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857009440 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471857009441 DNA binding residues [nucleotide binding] 471857009442 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471857009443 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471857009444 catalytic residue [active] 471857009445 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 471857009446 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 471857009447 motif II; other site 471857009448 hypothetical protein; Validated; Region: PRK07682 471857009449 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471857009450 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857009451 homodimer interface [polypeptide binding]; other site 471857009452 catalytic residue [active] 471857009453 Proteins of 100 residues with WXG; Region: WXG100; cl02005 471857009454 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 471857009455 N-acetyl-D-glucosamine binding site [chemical binding]; other site 471857009456 catalytic residue [active] 471857009457 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 471857009458 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 471857009459 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 471857009460 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 471857009461 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 471857009462 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 471857009463 putative active site [active] 471857009464 catalytic site [active] 471857009465 putative metal binding site [ion binding]; other site 471857009466 adenylosuccinate synthetase; Provisional; Region: PRK01117 471857009467 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 471857009468 GDP-binding site [chemical binding]; other site 471857009469 ACT binding site; other site 471857009470 IMP binding site; other site 471857009471 lipid kinase; Reviewed; Region: PRK13054 471857009472 Secretory lipase; Region: LIP; pfam03583 471857009473 Domain of unknown function (DUF1994); Region: DUF1994; pfam09352 471857009474 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 471857009475 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 471857009476 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 471857009477 active site 471857009478 intersubunit interface [polypeptide binding]; other site 471857009479 zinc binding site [ion binding]; other site 471857009480 Na+ binding site [ion binding]; other site 471857009481 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471857009482 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 471857009483 short chain dehydrogenase; Provisional; Region: PRK05872 471857009484 classical (c) SDRs; Region: SDR_c; cd05233 471857009485 NAD(P) binding site [chemical binding]; other site 471857009486 active site 471857009487 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471857009488 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 471857009489 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857009490 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471857009491 DNA binding residues [nucleotide binding] 471857009492 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 471857009493 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 471857009494 active site 471857009495 dimer interface [polypeptide binding]; other site 471857009496 FAD binding domain; Region: FAD_binding_4; pfam01565 471857009497 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 471857009498 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 471857009499 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 471857009500 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857009501 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 471857009502 substrate binding site [chemical binding]; other site 471857009503 ATP binding site [chemical binding]; other site 471857009504 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471857009505 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471857009506 DNA binding site [nucleotide binding] 471857009507 domain linker motif; other site 471857009508 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471857009509 dimerization interface [polypeptide binding]; other site 471857009510 ligand binding site [chemical binding]; other site 471857009511 Subunit B of the Class III extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of protocatechuate; Region: PCA_45_Dioxygenase_B; cd07364 471857009512 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 471857009513 active site 471857009514 Fe(II) binding site [ion binding]; other site 471857009515 dimer interface [polypeptide binding]; other site 471857009516 tetramer interface [polypeptide binding]; other site 471857009517 Subunit A of the Class III Extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, and similar enzymes; Region: PCA_45_Doxase_A_like; cd07921 471857009518 dimer interface [polypeptide binding]; other site 471857009519 tetramer interface [polypeptide binding]; other site 471857009520 active site 471857009521 Muconolactone delta-isomerase; Region: MIase; cl01992 471857009522 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471857009523 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471857009524 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 471857009525 hypothetical protein; Validated; Region: PRK06201 471857009526 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 471857009527 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857009528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471857009529 active site 471857009530 phosphorylation site [posttranslational modification] 471857009531 intermolecular recognition site; other site 471857009532 dimerization interface [polypeptide binding]; other site 471857009533 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471857009534 DNA binding residues [nucleotide binding] 471857009535 dimerization interface [polypeptide binding]; other site 471857009536 PAS domain S-box; Region: sensory_box; TIGR00229 471857009537 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 471857009538 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 471857009539 GAF domain; Region: GAF; cl00853 471857009540 Histidine kinase; Region: HisKA_3; pfam07730 471857009541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857009542 ATP binding site [chemical binding]; other site 471857009543 Mg2+ binding site [ion binding]; other site 471857009544 G-X-G motif; other site 471857009545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471857009546 metabolite-proton symporter; Region: 2A0106; TIGR00883 471857009547 putative substrate translocation pore; other site 471857009548 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471857009549 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471857009550 NAD(P) binding site [chemical binding]; other site 471857009551 catalytic residues [active] 471857009552 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 471857009553 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 471857009554 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 471857009555 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 471857009556 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 471857009557 classical (c) SDRs; Region: SDR_c; cd05233 471857009558 NAD(P) binding site [chemical binding]; other site 471857009559 active site 471857009560 anthranilate synthase; Provisional; Region: PRK13566 471857009561 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 471857009562 Clp amino terminal domain; Region: Clp_N; pfam02861 471857009563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471857009564 Walker A motif; other site 471857009565 ATP binding site [chemical binding]; other site 471857009566 Walker B motif; other site 471857009567 arginine finger; other site 471857009568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471857009569 Walker A motif; other site 471857009570 ATP binding site [chemical binding]; other site 471857009571 Walker B motif; other site 471857009572 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 471857009573 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 471857009574 heme-binding site [chemical binding]; other site 471857009575 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 471857009576 FMN reductase; Validated; Region: fre; PRK08051 471857009577 FAD binding pocket [chemical binding]; other site 471857009578 FAD binding motif [chemical binding]; other site 471857009579 phosphate binding motif [ion binding]; other site 471857009580 beta-alpha-beta structure motif; other site 471857009581 NAD binding pocket [chemical binding]; other site 471857009582 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 471857009583 DNA binding residues [nucleotide binding] 471857009584 putative dimer interface [polypeptide binding]; other site 471857009585 chaperone protein DnaJ; Provisional; Region: PRK14279 471857009586 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 471857009587 HSP70 interaction site [polypeptide binding]; other site 471857009588 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 471857009589 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 471857009590 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 471857009591 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 471857009592 dimer interface [polypeptide binding]; other site 471857009593 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 471857009594 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 471857009595 Uncharacterized conserved protein [Function unknown]; Region: COG3595 471857009596 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 471857009597 substrate binding site [chemical binding]; other site 471857009598 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471857009599 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857009600 Bacterial transcriptional regulator; Region: IclR; pfam01614 471857009601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 471857009602 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857009603 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 471857009604 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 471857009605 Cysteine-rich domain; Region: CCG; pfam02754 471857009606 Cysteine-rich domain; Region: CCG; pfam02754 471857009607 Protein of unknown function (DUF742); Region: DUF742; pfam05331 471857009608 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 471857009609 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471857009610 active site 471857009611 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 471857009612 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 471857009613 trimer interface [polypeptide binding]; other site 471857009614 active site 471857009615 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471857009616 VanZ like family; Region: VanZ; cl01971 471857009617 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857009618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 471857009619 active site 471857009620 phosphorylation site [posttranslational modification] 471857009621 intermolecular recognition site; other site 471857009622 dimerization interface [polypeptide binding]; other site 471857009623 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471857009624 DNA binding residues [nucleotide binding] 471857009625 dimerization interface [polypeptide binding]; other site 471857009626 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 471857009627 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 471857009628 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 471857009629 FAD binding site [chemical binding]; other site 471857009630 substrate binding site [chemical binding]; other site 471857009631 catalytic residues [active] 471857009632 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 471857009633 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 471857009634 oligomerisation interface [polypeptide binding]; other site 471857009635 mobile loop; other site 471857009636 roof hairpin; other site 471857009637 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471857009638 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 471857009639 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 471857009640 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 471857009641 Walker A/P-loop; other site 471857009642 ATP binding site [chemical binding]; other site 471857009643 Q-loop/lid; other site 471857009644 ABC transporter signature motif; other site 471857009645 Walker B; other site 471857009646 D-loop; other site 471857009647 H-loop/switch region; other site 471857009648 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 471857009649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471857009650 dimer interface [polypeptide binding]; other site 471857009651 conserved gate region; other site 471857009652 putative PBP binding loops; other site 471857009653 ABC-ATPase subunit interface; other site 471857009654 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 471857009655 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 471857009656 substrate binding pocket [chemical binding]; other site 471857009657 membrane-bound complex binding site; other site 471857009658 hinge residues; other site 471857009659 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 471857009660 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 471857009661 metal binding site [ion binding]; metal-binding site 471857009662 putative dimer interface [polypeptide binding]; other site 471857009663 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 471857009664 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 471857009665 TPP-binding site [chemical binding]; other site 471857009666 tetramer interface [polypeptide binding]; other site 471857009667 heterodimer interface [polypeptide binding]; other site 471857009668 phosphorylation loop region [posttranslational modification] 471857009669 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 471857009670 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 471857009671 alpha subunit interface [polypeptide binding]; other site 471857009672 TPP binding site [chemical binding]; other site 471857009673 heterodimer interface [polypeptide binding]; other site 471857009674 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471857009675 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 471857009676 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471857009677 E3 interaction surface; other site 471857009678 lipoyl attachment site [posttranslational modification]; other site 471857009679 e3 binding domain; Region: E3_binding; pfam02817 471857009680 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 471857009681 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 471857009682 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471857009683 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471857009684 enoyl-CoA hydratase; Region: PLN02864 471857009685 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 471857009686 active site 2 [active] 471857009687 active site 1 [active] 471857009688 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 471857009689 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857009690 NAD(P) binding site [chemical binding]; other site 471857009691 active site 471857009692 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 471857009693 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471857009694 dimer interface [polypeptide binding]; other site 471857009695 active site 471857009696 Predicted transcriptional regulator [Transcription]; Region: COG2345 471857009697 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857009698 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471857009699 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 471857009700 Walker A/P-loop; other site 471857009701 ATP binding site [chemical binding]; other site 471857009702 Q-loop/lid; other site 471857009703 ABC transporter signature motif; other site 471857009704 Walker B; other site 471857009705 D-loop; other site 471857009706 H-loop/switch region; other site 471857009707 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471857009708 DoxX; Region: DoxX; cl00976 471857009709 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 471857009710 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 471857009711 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 471857009712 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216 471857009713 active site/substrate binding site [active] 471857009714 tetramer interface [polypeptide binding]; other site 471857009715 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 471857009716 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471857009717 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 471857009718 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 471857009719 active site 471857009720 substrate-binding site [chemical binding]; other site 471857009721 metal-binding site [ion binding] 471857009722 GTP binding site [chemical binding]; other site 471857009723 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 471857009724 G1 box; other site 471857009725 GTP/Mg2+ binding site [chemical binding]; other site 471857009726 Switch I region; other site 471857009727 G2 box; other site 471857009728 Switch II region; other site 471857009729 G3 box; other site 471857009730 G4 box; other site 471857009731 G5 box; other site 471857009732 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 471857009733 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 471857009734 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471857009735 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471857009736 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 471857009737 Walker A/P-loop; other site 471857009738 ATP binding site [chemical binding]; other site 471857009739 Q-loop/lid; other site 471857009740 ABC transporter signature motif; other site 471857009741 Walker B; other site 471857009742 D-loop; other site 471857009743 H-loop/switch region; other site 471857009744 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 471857009745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471857009746 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471857009747 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 471857009748 Walker A/P-loop; other site 471857009749 ATP binding site [chemical binding]; other site 471857009750 Q-loop/lid; other site 471857009751 ABC transporter signature motif; other site 471857009752 Walker B; other site 471857009753 D-loop; other site 471857009754 H-loop/switch region; other site 471857009755 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471857009756 Histidine kinase; Region: HisKA_3; pfam07730 471857009757 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471857009758 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857009759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471857009760 active site 471857009761 phosphorylation site [posttranslational modification] 471857009762 intermolecular recognition site; other site 471857009763 dimerization interface [polypeptide binding]; other site 471857009764 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471857009765 DNA binding residues [nucleotide binding] 471857009766 dimerization interface [polypeptide binding]; other site 471857009767 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 471857009768 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 471857009769 active site 471857009770 putative substrate binding pocket [chemical binding]; other site 471857009771 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471857009772 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 471857009773 Walker A/P-loop; other site 471857009774 ATP binding site [chemical binding]; other site 471857009775 Q-loop/lid; other site 471857009776 ABC transporter signature motif; other site 471857009777 Walker B; other site 471857009778 D-loop; other site 471857009779 H-loop/switch region; other site 471857009780 Predicted transcriptional regulators [Transcription]; Region: COG1725 471857009781 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471857009782 DNA-binding site [nucleotide binding]; DNA binding site 471857009783 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 471857009784 Protein of unknown function (DUF461); Region: DUF461; cl01071 471857009785 short chain dehydrogenase; Provisional; Region: PRK08219 471857009786 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857009787 NAD(P) binding site [chemical binding]; other site 471857009788 active site 471857009789 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 471857009790 riboflavin kinase; Region: PLN02940 471857009791 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 471857009792 motif II; other site 471857009793 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 471857009794 Myo-inositol-1-phosphate synthase; Region: Inos-1-P_synth; cl00554 471857009795 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471857009796 Transglycosylase; Region: Transgly; cl07896 471857009797 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 471857009798 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 471857009799 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 471857009800 endonuclease IV; Provisional; Region: PRK01060 471857009801 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cd00019 471857009802 AP (apurinic/apyrimidinic) site pocket; other site 471857009803 DNA interaction; other site 471857009804 Metal-binding active site; metal-binding site 471857009805 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 471857009806 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 471857009807 dimer interface [polypeptide binding]; other site 471857009808 ssDNA binding site [nucleotide binding]; other site 471857009809 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471857009810 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 471857009811 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 471857009812 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 471857009813 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 471857009814 replicative DNA helicase; Region: DnaB; TIGR00665 471857009815 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 471857009816 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 471857009817 Walker A motif; other site 471857009818 ATP binding site [chemical binding]; other site 471857009819 Walker B motif; other site 471857009820 DNA binding loops [nucleotide binding] 471857009821 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 471857009822 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 471857009823 putative active site [active] 471857009824 metal binding site [ion binding]; metal-binding site 471857009825 Domain of unknown function DUF20; Region: UPF0118; cl00465 471857009826 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471857009827 ATP binding site [chemical binding]; other site 471857009828 Mg2+ binding site [ion binding]; other site 471857009829 G-X-G motif; other site 471857009830 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471857009831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471857009832 active site 471857009833 phosphorylation site [posttranslational modification] 471857009834 intermolecular recognition site; other site 471857009835 dimerization interface [polypeptide binding]; other site 471857009836 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471857009837 DNA binding residues [nucleotide binding] 471857009838 dimerization interface [polypeptide binding]; other site 471857009839 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 471857009840 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 471857009841 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 471857009842 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 471857009843 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of...; Region: ribokinase; cd01174 471857009844 substrate binding site [chemical binding]; other site 471857009845 dimer interface [polypeptide binding]; other site 471857009846 ATP binding site [chemical binding]; other site 471857009847 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 471857009848 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471857009849 active site 471857009850 HIGH motif; other site 471857009851 nucleotide binding site [chemical binding]; other site 471857009852 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471857009853 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471857009854 active site 471857009855 KMSKS motif; other site 471857009856 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 471857009857 tRNA binding surface [nucleotide binding]; other site 471857009858 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 471857009859 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 471857009860 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 471857009861 active site 471857009862 NTP binding site [chemical binding]; other site 471857009863 metal binding triad [ion binding]; metal-binding site 471857009864 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 471857009865 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 471857009866 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 471857009867 active site 471857009868 Ap6A binding site [chemical binding]; other site 471857009869 nudix motif; other site 471857009870 metal binding site [ion binding]; metal-binding site 471857009871 integral membrane protein MviN; Region: mviN; TIGR01695 471857009872 MatE; Region: MatE; cl10513 471857009873 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 471857009874 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471857009875 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471857009876 DNA binding residues [nucleotide binding] 471857009877 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 471857009878 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471857009879 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471857009880 catalytic residues [active] 471857009881 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471857009882 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471857009883 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 471857009884 active site 471857009885 metal binding site [ion binding]; metal-binding site 471857009886 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471857009887 Coenzyme A binding pocket [chemical binding]; other site 471857009888 aspartate aminotransferase; Provisional; Region: PRK06836 471857009889 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471857009890 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471857009891 homodimer interface [polypeptide binding]; other site 471857009892 catalytic residue [active] 471857009893 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 471857009894 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 471857009895 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 471857009896 ParB-like partition proteins; Region: parB_part; TIGR00180 471857009897 ParB-like nuclease domain; Region: ParBc; cl02129 471857009898 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 471857009899 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 471857009900 P-loop; other site 471857009901 Magnesium ion binding site [ion binding]; other site 471857009902 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 471857009903 Magnesium ion binding site [ion binding]; other site 471857009904 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 471857009905 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 471857009906 G-X-X-G motif; other site 471857009907 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 471857009908 RxxxH motif; other site 471857009909 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 471857009910 Domain of unknown function DUF37; Region: DUF37; cl00506 471857009911 Ribonuclease P; Region: Ribonuclease_P; cl00457 471857009912 Ribosomal protein L34; Region: Ribosomal_L34; cl00370